MCID: OBS001
MIFTS: 51

Obstructive Jaundice malady

Summaries for Obstructive Jaundice

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MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and hepatitis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds cysteinylglycine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

obstructive jaundice 8
obstructive hyperbilirubinemia 8
cholestatic jaundice syndrome 8
obstructive jaundice nos 8
jaundice, obstructive 60
cholestatic jaundice 8
jaundice obstructive 44
jaundice cholestatic 44


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Disease Ontology8 DOID:13603
MeSH34 D041781
NCIt39 C34742

Related Diseases for Obstructive Jaundice

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17GeneCards, 18GeneDecks
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Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.3SCT, GGT1, ALPP
2hepatitis31.1CCL27, TTR, GGT1, CEACAM1, ALPP
3hepatocellular carcinoma30.8CCL20, SCT, ABCC3, GGT1, SRF, CEACAM1
4acute pancreatitis30.8SCT, LBP
5tuberculosis30.7SRF
6adenocarcinoma30.7UCP2, SCT, CLDN4, ABCC3, GGT1, SRF
7pancreatic cancer30.6GGT1, ABCC3, CLDN4, SCT, UCP2, CCL20
8cholangitis30.6ALPP, GGT1
9melanoma30.5CCL20, SRF, ASAH2, CEACAM1
10adenoma30.5CEACAM1, GGT1, CLDN4, SCT
11cholangiocarcinoma30.4SCT, GGT1, ALPP
12myeloma30.4ALPP, CEACAM1
13leukemia30.4CCL20, ITGAX, ABCC3, TTR, SRF, FUT4
14hepatitis c30.2CCL20, GGT1
15cholestasis30.2ALPP, GGT1, ABCC3
16liver cirrhosis30.2SCT, TTR, GGT1
17colorectal cancer30.2ALPP, CEACAM1, ABCC3
18lung cancer30.2ALPP, CEACAM1, FUT4, SRF, ABCC3, LBP
19viral hepatitis30.1GGT1
20hypophosphatasia30.1ALPP
21peritonitis30.0LBP
22choledocholithiasis29.9ALPP, GGT1
23hypophosphatemia29.9ALPP
24intrahepatic cholestasis29.9ALPP, GGT1, SCT
25atherosclerosis29.9UCP2, GGT1, SRF
26ulcerative colitis29.9CCL20, LBP, ITGAX, BLVRB, SRF
27diabetes mellitus29.9UCP2, SCT, GGT1, ALPP
28intestinal obstruction10.7
29duodenitis10.5
30duodenal obstruction10.5
31cystadenoma10.4
32hepatitis a10.4
33liver disease10.4
34choledochal cyst10.3
35polycystic liver disease10.3
36neurofibroma10.3
37non-hodgkin lymphoma10.3
38burkitt's lymphoma10.3
39acute leukemia10.3
40cholecystitis10.3
41hodgkin's lymphoma10.3
42multiple myeloma10.3
43neonatal jaundice10.3
44plasmacytoma10.3
45secondary syphilis10.2
46syphilis10.2
47lutz richner landolt syndrome10.2
48neurofibromatosis10.2
49acute myeloid leukemia10.2
50gastroduodenitis10.2

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Clinical Features for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Obstructive Jaundice

Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

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Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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32MalaCards
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MalaCards organs/tissues related to Obstructive Jaundice:

32
Liver, Pancreas, Lung, Myeloid, Brain, Lymph node, B cells, T cells, Testes, Bone marrow, Bone, Spleen, Kidney, Appendix, Endothelial, Monocytes, Thymus, Heart, Prostate, Ovary, Breast, Skeletal muscle, Small intestine, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Obstructive Jaundice:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9CEACAM1, SCT, LBP, CLDN4, ABCC3, TTR

Publications for Obstructive Jaundice

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50PubMed
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Articles related to Obstructive Jaundice:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats. (23613625)
2013
2
Effects of biliary drainage on the intestinal barrier function in obstructive jaundice. (23933919)
2013
3
Protective effects of ginseng total saponins against hepatic ischemia/reperfusion injury in experimental obstructive jaundice rats. (24004049)
2013
4
Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. (22100509)
2012
5
Hepatocellular carcinoma with obstructive jaundice: endoscopic and percutaneous biliary drainage. (23258100)
2012
6
Effect of preoperative biliary drainage on malignant obstructive jaundice: a meta-analysis. (21253401)
2011
7
Obstructive jaundice for biliary mold due to foreign body. (21341936)
2011
8
Common bile duct carcinoid mimicking the clinical, EUS, and ERCP findings of cholangiocarcinoma: a rare but potentially curable cause of obstructive jaundice. (21723230)
2011
9
Testicular seminoma metastasis to pancreas: a rare cause of obstructive jaundice. (20360785)
2010
10
The effect of honey on the intestinal anastomotic wound healing in rats with obstructive jaundice. (20568415)
2010
11
Nintinol self-expandable metallic stenting in management of malignant obstructive jaundice: a case series. (22308128)
2010
12
Obstructive jaundice as a presenting symptom of metastatic carcinoma of the prostate. (21857878)
2009
13
Changes of serum cytokines and expression of inducible nitric oxide synthase mRNA by Kupffer cells after relief from obstructive jaundice in rats. (19220682)
2009
14
Effectiveness of intraportal mexidol infusions in the treatment of obstructive jaundice. (19824201)
2009
15
Obstructive jaundice secondary to a pancreatic plasmacytoma. (18848645)
2009
16
Obstructive jaundice due to primary choroidal malignant melanoma metastasis: an unusual presentation. (19568587)
2009
17
Baroreflex sensitivity is impaired in patients with obstructive jaundice. (19672165)
2009
18
Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice. (18528939)
2008
19
Ovarian Non-Hodgkin's Lymphoma presenting as obstructive jaundice - a case report. (18923596)
2008
20
A case of obstructive jaundice with severe hypercholesterolemia probably due to lipoprotein-Y. (18981653)
2008
21
Effect of propolis on oxidative stress and histomorphology of liver tissue in experimental obstructive jaundice. (18525208)
2008
22
Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice. (17876893)
2007
23
Primary duodenal lymphoma producing obstructive jaundice. (17444348)
2007
24
Obstructive jaundice: a manifestation of pancreatic tuberculosis. (17824465)
2007
25
Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice. (16500417)
2006
26
One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent. (16688837)
2006
27
Phagocytosis and production of H2O2 by human peripheral blood mononuclear cells from patients with obstructive jaundice. (16636599)
2006
28
Prominent hypophosphatemia due to proximal tubulopathy mimicking Fanconi's syndrome in a patient with obstructive jaundice. (16629234)
2006
29
Nutritional risk index predicts a high-risk population in patients with obstructive jaundice. (16675070)
2006
30
Obstructive jaundice caused by biliary stone formation around the stent after liver transplantation. (17032432)
2006
31
Obstructive jaundice. (16512074)
2005
32
Alcoholic chronic pancreatitis with simultaneous multiple severe complications--extrahepatic portal obliteration, obstructive jaundice and duodenal stricture. (16001677)
2005
33
Obstructive jaundice in AIDS: diagnosis of biliary tuberculosis by ERCP. (15229450)
2004
34
Ascariasis as a cause of obstructive jaundice in a renal transplant patient. (15365970)
2004
35
Magnetic resonance cholangiopancreatography in obstructive jaundice. (15492607)
2004
36
Effects of different drainage procedures on levels of serum endotoxin and tumor necrosis factor in patients with malignant obstructive jaundice. (14599953)
2003
37
Annular pancreas with obstructive jaundice: beware of underlying neoplasm. (12370545)
2002
38
Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat. (11843026)
2002
39
Effectiveness of endoscopic biliary drainage for unresectable hepatocellular carcinoma associated with obstructive jaundice. (11291880)
2001
40
Anorexia and the effect of internal biliary drainage on food intake in patients with obstructive jaundice. (11333095)
2001
41
The role of oxygen free radicals in acute renal failure complicating obstructive jaundice: an experimental study. (9515237)
1998
42
Obstructive jaundice caused by lymphangitis carcinomatosa of bile duct wall from gastric carcinoma. (9516509)
1998
43
Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case. (8892023)
1996
44
Obstructive jaundice associated with polycystic liver disease. (9184868)
1996
45
Multifocal mucus secreting papillary adenocarcinoma of the bile duct causing obstructive jaundice. (8363342)
1993
46
Urinary sodium levels related to jaundice duration in the assessment of postoperative risk of hepatorenal syndrome in elderly patients undergoing surgery for biliary obstruction. (2745041)
1989
47
Obstructive jaundice caused by blastomycosis of the lymph nodes around the common bile duct. (3268076)
1988
48
Hepatorenal syndrome associated with obstructive jaundice. (4067231)
1985
49
Pancreatic cystadenoma with obstructive jaundice. (6719173)
1984
50
Obstructive jaundice caused by polycystic liver disease. (7403520)
1980

Genetic Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

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Pathways for genes affiliated with Obstructive Jaundice

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53Reactome, 51QIAGEN, 29KEGG
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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CCL25, CCL20, CCL27
2
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10.2SRF, CCL27, CCL20, CCL25
3
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10.1ABCC3, KHK, GGT1, ASAH2, FUT4, ALPP
4
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10.1SRF, CLDN4, ITGAX, CCL27, CCL20, CCL25

Compounds for genes affiliated with Obstructive Jaundice

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1cysteinylglycine44 2411.7TTR, GGT1
2cycloheximide4410.7ITGAX, CEACAM1, ALPP
3ursodeoxycholic acid44 11 2412.7SCT, ABCC3, GGT1, ALPP
4bezafibrate44 28 1112.7ALPP, GGT1, UCP2
5rantes4410.7CCL20, SCT
6phosphorus4410.7ALPP, GGT1, TTR
7heparin44 28 11 2413.7SRF, LBP
8diflunisal44 1111.6ALPP, TTR
9glucose4410.6UCP2, SCT, SRF, CEACAM1
10peptidoglycan44 2811.6SRF, LBP, CCL20
11thyroxine44 2411.6UCP2, SCT, TTR, GGT1, ALPP
12sialic acid4410.6GGT1, SRF, FUT4, CEACAM1
13endotoxin4410.6CCL20, LBP, BLVRB, SRF
14vitamin b124410.6ALPP, GGT1, TTR
15indomethacin44 59 28 1113.6SCT, ITGAX, BLVRB, ABCC3, GGT1
16norepinephrine44 11 2412.6ALPP, SRF, TTR, SCT, UCP2
17arachidonic acid44 28 11 2413.6UCP2, LBP, ITGAX, SRF, ASAH2
18guanine44 11 2412.6SRF, GGT1, TTR, SCT
19phenobarbital44 28 1112.6ABCC3, GGT1, ALPP
20aspartate4410.6CCL27, SCT, LBP, TTR, GGT1, ALPP
21dopamine44 28 11 2413.6UCP2, SCT, BLVRB, TTR, GGT1
22uric acid44 2411.5TTR, GGT1, SRF
23carnitine4410.5UCP2, TTR, SRF
24creatinine4410.5CCL27, LBP, TTR, GGT1, SRF, ALPP
25lactate4410.5UCP2, TTR, GGT1, SRF, ALPP
26iron44 2411.5CCL20, BLVRB, TTR, GGT1, SRF
27superoxide44 2411.5UCP2, LBP, ITGAX, BLVRB, SRF
28vitamin-e4410.5GGT1, TTR, UCP2
29testosterone44 59 11 2413.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
30nitric oxide44 11 2412.5CCL20, UCP2, LBP, ITGAX, BLVRB, ABCC3
31dexamethasone44 49 28 1113.5ALPP, CCL20, CCL27, LBP, ABCC3, GGT1
32polysaccharide4410.5CEACAM1, FUT4, GGT1, LBP
33arginine4410.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
34cholesterol44 28 11 2413.4CCL27, UCP2, LBP, ABCC3, TTR, GGT1
35glutamate4410.4SCT, BLVRB, TTR, GGT1, SRF, ALPP
36fibrinogen4410.4LBP, ITGAX, TTR, SRF
37lipid4410.4CCL27, UCP2, SCT, LBP, ABCC3, GGT1
38phospholipid4410.4SRF, ABCC3, LBP, SCT
39atp44 2811.4UCP2, SCT, BLVRB, ABCC3, KHK, SRF
40retinoic acid44 2411.4UCP2, SCT, ITGAX, ABCC3, TTR, SRF
41catecholamine4410.4BLVRB, SCT, UCP2
42alanine4410.4CCL20, CCL27, UCP2, LBP, TTR, GGT1
43acetylcholine44 49 28 11 2414.3SCT, BLVRB, GGT1, SRF
44calcium44 49 11 2413.3CCL25, CCL20, CCL27, UCP2, SCT, BLVRB
45potassium44 11 2412.2GGT1, BLVRB, SCT, UCP2
46homocysteine44 2411.2SRF, TTR, LBP
47serine4410.2SCT, LBP, CLDN4, SRF, ALPP
48verapamil44 49 28 11 2414.0ABCC3, GGT1, ALPP

GO Terms for genes affiliated with Obstructive Jaundice

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16Gene Ontology
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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CEACAM1, TTR, LBP, SCT, CCL27, CCL20

Biological processes related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.3CCL27, CCL20, CCL25

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3TTR, SCT, CCL25
2chemokine activityGO:00800910.0CCL27, CCL20, CCL25

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet