MCID: OBS001
MIFTS: 51

Obstructive Jaundice malady

Summaries for Obstructive Jaundice

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32MalaCards
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MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and hepatitis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds cysteinylglycine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

obstructive jaundice 8
obstructive hyperbilirubinemia 8
cholestatic jaundice syndrome 8
obstructive jaundice nos 8
jaundice, obstructive 60
cholestatic jaundice 8
jaundice obstructive 44
jaundice cholestatic 44


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Disease Ontology8 DOID:13603
MeSH34 D041781
NCIt39 C34742

Related Diseases for Obstructive Jaundice

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17GeneCards, 18GeneDecks
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Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.3SCT, GGT1, ALPP
2hepatitis31.1CCL27, TTR, GGT1, CEACAM1, ALPP
3hepatocellular carcinoma30.8CCL20, SCT, ABCC3, GGT1, SRF, CEACAM1
4acute pancreatitis30.8SCT, LBP
5tuberculosis30.7SRF
6adenocarcinoma30.7UCP2, SCT, CLDN4, ABCC3, GGT1, SRF
7pancreatic cancer30.6GGT1, ABCC3, CLDN4, SCT, UCP2, CCL20
8cholangitis30.6ALPP, GGT1
9melanoma30.5CCL20, SRF, ASAH2, CEACAM1
10adenoma30.5CEACAM1, GGT1, CLDN4, SCT
11cholangiocarcinoma30.4SCT, GGT1, ALPP
12myeloma30.4ALPP, CEACAM1
13leukemia30.4CCL20, ITGAX, ABCC3, TTR, SRF, FUT4
14hepatitis c30.2CCL20, GGT1
15cholestasis30.2ALPP, GGT1, ABCC3
16liver cirrhosis30.2SCT, TTR, GGT1
17colorectal cancer30.2ALPP, CEACAM1, ABCC3
18lung cancer30.2ALPP, CEACAM1, FUT4, SRF, ABCC3, LBP
19viral hepatitis30.1GGT1
20hypophosphatasia30.1ALPP
21peritonitis30.0LBP
22choledocholithiasis29.9ALPP, GGT1
23hypophosphatemia29.9ALPP
24intrahepatic cholestasis29.9ALPP, GGT1, SCT
25atherosclerosis29.9UCP2, GGT1, SRF
26ulcerative colitis29.9CCL20, LBP, ITGAX, BLVRB, SRF
27diabetes mellitus29.9UCP2, SCT, GGT1, ALPP
28intestinal obstruction10.7
29duodenitis10.5
30duodenal obstruction10.5
31cystadenoma10.4
32hepatitis a10.4
33liver disease10.4
34choledochal cyst10.3
35polycystic liver disease10.3
36neurofibroma10.3
37non-hodgkin lymphoma10.3
38burkitt's lymphoma10.3
39acute leukemia10.3
40cholecystitis10.3
41hodgkin's lymphoma10.3
42multiple myeloma10.3
43neonatal jaundice10.3
44plasmacytoma10.3
45secondary syphilis10.2
46syphilis10.2
47lutz richner landolt syndrome10.2
48neurofibromatosis10.2
49acute myeloid leukemia10.2
50gastroduodenitis10.2

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Clinical Features for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Obstructive Jaundice

Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

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Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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32MalaCards
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MalaCards organs/tissues related to Obstructive Jaundice:

32
Liver, Pancreas, Lung, Myeloid, Brain, B cells, Lymph node, Testes, Bone marrow, Spleen, Bone, T cells, Small intestine, Pituitary, Endothelial, Prostate, Monocytes, Breast, Skeletal muscle, Heart, Thymus, Kidney, Ovary, Appendix

Animal Models for Obstructive Jaundice or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Obstructive Jaundice:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9CEACAM1, SCT, LBP, CLDN4, ABCC3, TTR

Publications for Obstructive Jaundice

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50PubMed
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Articles related to Obstructive Jaundice:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
MACEI and MACawake of sevoflurane in infants with obstructive jaundice. (24330496)
2014
2
Obstructive jaundice as recurrence of lung adenocarcinoma. (22956154)
2013
3
Caution in interpretation of the tumor marker CA 19.9 in patients with obstructive jaundice: illustrative case reports. (23767270)
2013
4
Metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. (23354351)
2013
5
Hepatic cytokine response can be modulated using the Kupffer cell blocker gadolinium chloride in obstructive jaundice. (23168237)
2013
6
Lung Carcinoma Presenting as an Obstructive Jaundice: Case Series with Literature Review. (23999821)
2013
7
Giant villous duodenal adenoma with malignant change: an unusual cause of obstructive jaundice. (24285056)
2013
8
Endosonography for suspected obstructive jaundice with no definite pathology on ultrasonography. (24090635)
2013
9
The role of nasogastric intubation on postoperative gastrointestinal function in patients with obstructive jaundice. (24082589)
2012
10
Ectopic pancreas presenting as periampullary tumor with obstructive jaundice and pruritus is a rare diagnostic and therapeutic dilemma. A case report. (22072252)
2011
11
Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. (21737101)
2011
12
Obstructive jaundice caused by Clonorchiasis-associated duodenal papillitis: a case report. (21218042)
2011
13
What is appropriate procedure for preoperative biliary drainage in patients with obstructive jaundice awaiting pancreaticoduodenectomy? (22002271)
2011
14
Obstructive jaundice due to primary neurofibroma of the common bile duct. (20036204)
2011
15
Intestinal epithelial cell proliferation, apoptosis and expression of tight junction proteins in patients with obstructive jaundice. (20840373)
2011
16
Identification of obstructive jaundice-related microRNAs in mouse liver. (21410023)
2010
17
Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients. (20095884)
2010
18
Obstructive jaundice as a complication of a peptic duodenal ulcer mimicking pancreatic cancer. (21113877)
2010
19
Altered occludin expression in brain capillaries induced by obstructive jaundice in rats. (20170644)
2010
20
An unusual cause of obstructive jaundice. (21686538)
2009
21
Education and imaging. Hepatobiliary and pancreatic: Large cavernous hemangioma with obstructive jaundice. (19646022)
2009
22
Lymphoplasmacytic sclerosing pancreatitis with obstructive jaundice: a case report and review of the literature. (19745596)
2009
23
Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism. (19533807)
2009
24
Adenocarcinoma of the pancreas complicated by obstructive jaundice in pregnancy. (18850437)
2008
25
Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage. (18592157)
2008
26
An autopsy case of obstructive jaundice due to hepatic multiple peribiliary cysts accompanying hepatolithiasis. (17645517)
2008
27
Metastatic melanoma to the common bile duct causing obstructive jaundice: a case report. (17278211)
2007
28
Obstructive jaundice caused by primary duodenal lymphoma. Case report and review of the literature. (17630473)
2007
29
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
30
Therapeutic considerations in obstructive jaundice due to hepatic artery aneurysm. (18333248)
2006
31
Myeloid sarcoma of the extrahepatic bile ducts presenting as obstructive jaundice. (16948823)
2006
32
Xanthogranulomatous cholangitis causing obstructive jaundice: a case report. (16865792)
2006
33
Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice. (16809227)
2006
34
Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: effect of bombesin and neurotensin. (16733860)
2006
35
Obstructive jaundice due to isolated tuberculosis of the pancreas: endoscopic treatment instead of surgery? (16429362)
2006
36
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. (15625352)
2005
37
Hypereosinophilic syndrome with hepatobiliary masses and obstructive jaundice. (15702811)
2005
38
Inflammatory pseudotumour of the liver presenting with obstructive jaundice. (16018527)
2005
39
Obstructive jaundice as the presenting manifestation of Burkitt's lymphoma in a 4-year-old boy. (12709739)
2003
40
The effect of endoscopic retrograde cholangiopancreatography on the serum IL-18 and erythrocytes antioxidative capacity in biliary obstructive jaundice. (14500044)
2003
41
Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. (11354287)
2001
42
The relationship between protein kinase C signal pathway and the immunologic evaluation in patients with obstructive jaundice. (16201164)
2001
43
Obstructive jaundice in rats results in exaggerated hepatic production of tumor necrosis factor-alpha and systemic and tissue tumor necrosis factor-alpha levels after endotoxin. (9288133)
1997
44
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
45
Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. (7634181)
1995
46
Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice. (7966522)
1994
47
Polycystic liver disease with obstructive jaundice: treatment with ultrasound-guided cyst aspiration. (1544558)
1992
48
Atypical hepatic tuberculosis presenting as obstructive jaundice. (3421231)
1988
49
Renal failure in association with severe liver diseases and obstructive jaundice (hepatorenal syndrome). (13746227)
1961
50
PROTHROMBIN DEFICIENCY AND THE EFFECTS OF VITAMIN K IN OBSTRUCTIVE JAUNDICE AND BILIARY FISTULA. (17857347)
1939

Genetic Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for genes affiliated with Obstructive Jaundice

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53Reactome, 51QIAGEN, 29KEGG
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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CCL25, CCL20, CCL27
2
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10.2SRF, CCL27, CCL20, CCL25
3
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10.1ABCC3, KHK, GGT1, ASAH2, FUT4, ALPP
4
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10.1SRF, CLDN4, ITGAX, CCL27, CCL20, CCL25

Compounds for genes affiliated with Obstructive Jaundice

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1cysteinylglycine44 2411.7TTR, GGT1
2cycloheximide4410.7ITGAX, CEACAM1, ALPP
3ursodeoxycholic acid44 11 2412.7SCT, ABCC3, GGT1, ALPP
4bezafibrate44 28 1112.7ALPP, GGT1, UCP2
5rantes4410.7CCL20, SCT
6phosphorus4410.7ALPP, GGT1, TTR
7heparin44 28 11 2413.7SRF, LBP
8diflunisal44 1111.6ALPP, TTR
9glucose4410.6UCP2, SCT, SRF, CEACAM1
10peptidoglycan44 2811.6SRF, LBP, CCL20
11thyroxine44 2411.6UCP2, SCT, TTR, GGT1, ALPP
12sialic acid4410.6GGT1, SRF, FUT4, CEACAM1
13endotoxin4410.6CCL20, LBP, BLVRB, SRF
14vitamin b124410.6ALPP, GGT1, TTR
15indomethacin44 59 28 1113.6SCT, ITGAX, BLVRB, ABCC3, GGT1
16norepinephrine44 11 2412.6ALPP, SRF, TTR, SCT, UCP2
17arachidonic acid44 28 11 2413.6UCP2, LBP, ITGAX, SRF, ASAH2
18guanine44 11 2412.6SRF, GGT1, TTR, SCT
19phenobarbital44 28 1112.6ABCC3, GGT1, ALPP
20aspartate4410.6CCL27, SCT, LBP, TTR, GGT1, ALPP
21dopamine44 28 11 2413.6UCP2, SCT, BLVRB, TTR, GGT1
22uric acid44 2411.5TTR, GGT1, SRF
23carnitine4410.5UCP2, TTR, SRF
24creatinine4410.5CCL27, LBP, TTR, GGT1, SRF, ALPP
25lactate4410.5UCP2, TTR, GGT1, SRF, ALPP
26iron44 2411.5CCL20, BLVRB, TTR, GGT1, SRF
27superoxide44 2411.5UCP2, LBP, ITGAX, BLVRB, SRF
28vitamin-e4410.5GGT1, TTR, UCP2
29testosterone44 59 11 2413.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
30nitric oxide44 11 2412.5CCL20, UCP2, LBP, ITGAX, BLVRB, ABCC3
31dexamethasone44 49 28 1113.5ALPP, CCL20, CCL27, LBP, ABCC3, GGT1
32polysaccharide4410.5CEACAM1, FUT4, GGT1, LBP
33arginine4410.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
34cholesterol44 28 11 2413.4CCL27, UCP2, LBP, ABCC3, TTR, GGT1
35glutamate4410.4SCT, BLVRB, TTR, GGT1, SRF, ALPP
36fibrinogen4410.4LBP, ITGAX, TTR, SRF
37lipid4410.4CCL27, UCP2, SCT, LBP, ABCC3, GGT1
38phospholipid4410.4SRF, ABCC3, LBP, SCT
39atp44 2811.4UCP2, SCT, BLVRB, ABCC3, KHK, SRF
40retinoic acid44 2411.4UCP2, SCT, ITGAX, ABCC3, TTR, SRF
41catecholamine4410.4BLVRB, SCT, UCP2
42alanine4410.4CCL20, CCL27, UCP2, LBP, TTR, GGT1
43acetylcholine44 49 28 11 2414.3SCT, BLVRB, GGT1, SRF
44calcium44 49 11 2413.3CCL25, CCL20, CCL27, UCP2, SCT, BLVRB
45potassium44 11 2412.2GGT1, BLVRB, SCT, UCP2
46homocysteine44 2411.2SRF, TTR, LBP
47serine4410.2SCT, LBP, CLDN4, SRF, ALPP
48verapamil44 49 28 11 2414.0ABCC3, GGT1, ALPP

GO Terms for genes affiliated with Obstructive Jaundice

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16Gene Ontology
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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CEACAM1, TTR, LBP, SCT, CCL27, CCL20

Biological processes related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.3CCL27, CCL20, CCL25

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3TTR, SCT, CCL25
2chemokine activityGO:00800910.0CCL27, CCL20, CCL25

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet