MCID: OBS001
MIFTS: 53

Obstructive Jaundice

Categories: Genetic diseases, Gastrointestinal diseases

Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice 12 14
Jaundice, Obstructive 41 69
Obstructive Hyperbilirubinemia 12
Cholestatic Jaundice Syndrome 12
Obstructive Jaundice Nos 12
Cholestatic Jaundice 12
Jaundice Obstructive 51
Jaundice Cholestatic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:13603
MeSH 41 D041781
NCIt 46 C34742
UMLS 69 C0022354

Summaries for Obstructive Jaundice

MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to hepatitis and cholecystitis, and has symptoms including jaundice (not of newborn) and icterus. An important gene associated with Obstructive Jaundice is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways are Selenium Micronutrient Network and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Lactulose and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 hepatitis 30.5 F2 GGT1 GPT SLC17A5 TNF
2 cholecystitis 30.3 ALB F2 GPT
3 abdominal tuberculosis 30.1 ALB F2
4 hepatorenal syndrome 29.7 ALB EDN1 F2 REN
5 fascioliasis 29.7 ALB ALPP GPT SLC17A5
6 biliary atresia 29.7 ALB GPT HGF
7 sclerosing cholangitis 29.5 ALB GPBAR1 TNF
8 gastroenteritis 29.5 ALB CXCL8 IL6 TNF
9 myeloma, multiple 29.5 ALB CD79A CXCL8 IL6
10 prostatitis 29.4 CXCL8 IL6 TNF
11 portal hypertension 29.3 ALB EDN1 F2 GPT TNF
12 choledocholithiasis 29.3 ALB ALPP F2 GPT SLC17A5
13 monocytic leukemia 29.3 CXCL8 IL6 TNF
14 hepatic tuberculosis 29.2 ALB ALPP F2 GGT1 GPT
15 cholestasis 29.2 ALPP F2 GGT1 GPT SLC25A13
16 clonorchiasis 29.1 CD79A CXCL8 TNF
17 cholangitis 29.0 ALB F2 GGT1 GPBAR1 GPT IL6
18 hepatocellular carcinoma 29.0 ALB CXCL8 F2 GGT1 HGF IL6
19 biliary tract disease 29.0 ALB F2 GGT1 GPBAR1 SLC25A13
20 peritonitis 28.7 ALB CXCL8 F2 IL6 TNF
21 liver cirrhosis 28.3 ALB EDN1 F2 GGT1 GPT HGF
22 liver disease 27.8 ALB ALPP F2 GGT1 GPT HGF
23 mirizzi syndrome 11.2
24 biliary malformation with renal tubular insufficiency 11.2
25 cholestasis, benign recurrent intrahepatic, 1 11.2
26 acth deficiency, isolated 11.0
27 cholestasis, benign recurrent intrahepatic, 2 11.0
28 bile acid synthesis defect, congenital, 1 11.0
29 congenital disorder of glycosylation, type ik 11.0
30 paraquat poisoning 10.6 GPT SLC17A5
31 paramyloidosis 10.6 ALB TTR
32 acute adrenal insufficiency 10.6 IL6 REN
33 pyridoxine deficiency 10.6 GPT SLC17A5
34 scorpion envenomation 10.6 IL6 TNF
35 pancreatitis 10.6
36 benign essential hypertension 10.5 ALB REN
37 alkaline phosphatase, plasma level of, quantitative trait locus 1 10.5 ALPP GGT1
38 hypertension, diastolic 10.5 GGT1 REN
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
40 antipyrine metabolism 10.5 ALB F2
41 non-a-e hepatitis 10.5 ALB F2
42 malignant renovascular hypertension 10.5 EDN1 REN
43 hepatoportal sclerosis 10.5 F2 GPT
44 kidney papillary necrosis 10.5 ALB REN
45 sudden sensorineural hearing loss 10.4 F2 IL6
46 primary hepatic neuroendocrine carcinoma 10.4 ALPP GPT
47 intestinal impaction 10.4 F2 REN
48 endometritis 10.4 IL6 SLC17A5 TNF
49 leukomalacia 10.4 IL6 SLC17A5 TNF
50 null-cell leukemia 10.4 IL6 TNF

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to Obstructive Jaundice

Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:


jaundice (not of newborn), icterus

MGI Mouse Phenotypes related to Obstructive Jaundice:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 SLC25A13 TNF EDN1 F2 GGT1 GPBAR1
2 homeostasis/metabolism MP:0005376 9.93 CD79A TNF EDN1 TTR F2 GGT1
3 liver/biliary system MP:0005370 9.5 SLC25A13 CD79A TNF GPBAR1 HGF IL6
4 renal/urinary system MP:0005367 9.23 CD79A EDN1 GGT1 GPBAR1 IL6 REN

Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lactulose Approved Phase 4 4618-18-2 11333
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Ofloxacin Approved Phase 4 82419-36-1 4583
4
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
5 Renal Agents Phase 4
6 Topoisomerase Inhibitors Phase 4
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Anti-Bacterial Agents Phase 4
10 Anti-Infective Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Antitubercular Agents Phase 4
13
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
14
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
15
Nicotinamide Approved, Investigational, Nutraceutical Phase 3 98-92-0 936
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17 Hematoporphyrin Derivative Phase 2, Phase 3
18 Dihematoporphyrin Ether Phase 2, Phase 3
19 Vitamins Phase 3
20 Micronutrients Phase 3
21 Trace Elements Phase 3
22 Nicotinic Acids Phase 3
23 Vasodilator Agents Phase 3
24 Vitamin B Complex Phase 3
25 Pharmaceutical Solutions Phase 3
26 Hypolipidemic Agents Phase 3
27 Antimetabolites Phase 3
28 Lipid Regulating Agents Phase 3
29 methionine Nutraceutical Phase 3
30 Folate Nutraceutical Phase 3
31 Vitamin B3 Nutraceutical Phase 3
32 Vitamin B9 Nutraceutical Phase 3
33
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
34
Neostigmine Approved, Vet_approved Phase 1, Phase 2 59-99-4 4456
35
Menthol Approved Phase 2 2216-51-5 16666
36
Pancrelipase Approved, Investigational Phase 2 53608-75-6
37 pancreatin Phase 2
38
Bilirubin Phase 2,Phase 1 635-65-4 5280352
39 Cholagogues and Choleretics Phase 2
40 Cholinergic Agents Phase 1, Phase 2
41 Cholinesterase Inhibitors Phase 1, Phase 2
42 Gastrointestinal Agents Phase 2
43 Neurotransmitter Agents Phase 1, Phase 2
44 Peripheral Nervous System Agents Phase 1, Phase 2
45 Anti-Inflammatory Agents Phase 1, Phase 2
46 Liver Extracts Phase 2,Phase 1
47 Autonomic Agents Phase 1, Phase 2
48 Fat Emulsions, Intravenous Phase 1, Phase 2
49 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
50 Soy Bean Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 49)

# Name Status NCT ID Phase Drugs
1 Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice Unknown status NCT00731419 Phase 4
2 Human Kidney Histopathology in Obstructive Jaundice Completed NCT01090193 Phase 4
3 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
4 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
5 Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice Unknown status NCT01744938 Phase 3
6 RFA RCT for Pancreatic or Bile Duct Cancer Unknown status NCT02166190 Phase 3
7 Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block. Completed NCT00391183 Phase 2, Phase 3
8 Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma Recruiting NCT01755013 Phase 2, Phase 3
9 Remaxol® in Mechanical Jaundice of Non-malignant Origin Active, not recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
10 Remaxol® in Malignant Mechanical Jaundice Active, not recruiting NCT03416062 Phase 3 Remaxol®;Ringer's Solution
11 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
12 The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice Unknown status NCT01688375 Phase 2 Ursodeoxycholic Acid
13 Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
14 Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Operation. Unknown status NCT02279147 Phase 1, Phase 2 neostigmine methylsulfate,raceanisodamine hydrochloride
15 Evaluation of Preoperative Biliary Drainage Before Pancreatoduodenectomy Unknown status NCT01941342 Phase 2
16 Metal or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. Completed NCT02166840 Phase 2
17 Radiofrequency Ablation for Biliopancreatic Malignancy Completed NCT02468076 Phase 2
18 SMOFlipid to Lessen the Severity of Neonatal Cholestasis Terminated NCT02721277 Phase 1, Phase 2 SMOFlipid
19 Immune Function in Patients With Obstructive Jaundice Unknown status NCT01367821
20 Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage Unknown status NCT01686425
21 Efficacy and Safety of Endobiliary Radiofrequency Ablation by Using a Novel RF Catheter (ELRA®) on Maintaining the Patency of Endobiliary Metal Drainage in Patients With Malignant Biliary Strictures : A Double-arm Comparable Study Unknown status NCT02646514
22 Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice Unknown status NCT00155194
23 Application of n-3 Fatty to Patient of Jaundice Completed NCT03376945 trail cohort;control cohort
24 Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers Completed NCT01134276
25 Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Photofrin
26 Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer Completed NCT00409864
27 Outcome of Carbon Dioxide Versus Air Insufflations During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01321203
28 Malignant Obstruction ZILVER Against Routine Therapy (MOZART I) Completed NCT00196105
29 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
30 Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones Completed NCT02460315
31 Endoscopic Retrograde Cholangiopancreatography (ERCP) Based Sampling of Indeterminate Bile Duct Strictures Completed NCT01580709
32 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation Completed NCT02477228 Not Applicable
33 Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids Recruiting NCT02797665 corticosteroids
34 Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance Recruiting NCT03406676 Methylene Blue
35 Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression Recruiting NCT01191814
36 Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation Recruiting NCT03133026
37 Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression Recruiting NCT01675908
38 Efficacy of Partial Covered Double Bare Metal Stent Compared to Uncovered Double Bare Metal Stent in Malignant Biliary Obstruction Recruiting NCT02937246
39 Study of Abdominal Drainage in LCBDE+PC Recruiting NCT03120754
40 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417
41 A Study for Efficacy of Side-by-side Compared to Stent-in-stent Technique in the Endoscopic Management of Malignant Hilar Biliary Obstruction Recruiting NCT02659852
42 EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent Recruiting NCT03002051
43 Single-operator Digital Cholangioscopy for the Diagnosis of Malignant and Benign Biliary Strictures Recruiting NCT03307382
44 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
45 Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis Enrolling by invitation NCT02841800
46 Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses Not yet recruiting NCT03252379 Not Applicable
47 Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures Terminated NCT01721174
48 A Prospective, Randomized Study Evaluating the Effect of Biliary Stenting on EAU-FNA in Patients With Suspected Malignant Biliary Obstruction Terminated NCT01514058
49 Comparison of Biliary Stenting Alone vs. Stenting With Photodynamic Therapy (PDT) During ERCP Withdrawn NCT01439685

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

Genetic Tests for Obstructive Jaundice

Anatomical Context for Obstructive Jaundice

MalaCards organs/tissues related to Obstructive Jaundice:

38
Liver, Pancreas, Lung, Kidney, Brain, Lymph Node, Myeloid

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 738)
# Title Authors Year
1
Efficacy of<sup>125</sup>I Versus Non-<sup>125</sup>I Combined with Transcatheter Arterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma with Obstructive Jaundice. ( 29305738 )
2018
2
A Case of Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. ( 29434146 )
2018
3
Pathophysiological consequences of obstructive jaundice and perioperative management. ( 29428098 )
2018
4
MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. ( 29366780 )
2018
5
Hepatobiliary and Pancreatic: Rare cause of obstructive jaundice by Trichosporon asahii. ( 29372610 )
2018
6
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice. ( 29075881 )
2018
7
MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. ( 29105510 )
2018
8
Obstructive Jaundice Caused by Heterotopic Pancreas. ( 29215624 )
2017
9
A new intraductal radiofrequency ablation device for inoperable biliopancreatic tumors complicated by obstructive jaundice: the IGNITE-1 study. ( 28732391 )
2017
10
Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models. ( 28779259 )
2017
11
A late unusual complication after an open cholecystectomy: Amputation neuroma of the CBD causing obstructive jaundice. ( 28837915 )
2017
12
My First Patient: More Than Obstructive Jaundice. ( 28027099 )
2017
13
Von Meyenburg complexes in a patient with obstructive jaundice. ( 28899322 )
2017
14
Endoscopic ultrasound-guided choledochoduodenostomy for obstructive jaundice with venous collaterals around the bile duct wall (with video). ( 28440241 )
2017
15
Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis. ( 29037223 )
2017
16
Evaluation of liver function by means of serum cytokeratin 18 and hepatocyte growth factor levels in patients with obstructive jaundice. ( 29258405 )
2017
17
A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model. ( 28580342 )
2017
18
Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )
2017
19
Altered expression of differential gene and lncRNA in the lower thoracic spinal cord on different time courses of experimental obstructive jaundice model accompanied with altered peripheral nociception in rats. ( 29285317 )
2017
20
Magnetic Resonance Cholangiopancreatography (MRCP) Evaluation of Obstructive Jaundice in Comparison with Endoscopic Retrograde Cholangiopancreatography (ERCP). ( 28588181 )
2017
21
Obstructive Jaundice Caused by Hepatic Torsion in an Infant with Congenital Diaphragmatic Hernia. ( 28082781 )
2017
22
Clinical Study on Using (125)I Seeds Articles Combined with Biliary Stent Implantation in the Treatment of Malignant Obstructive Jaundice. ( 28739766 )
2017
23
An HIV-positive Case of Obstructive Jaundice Caused by Immune Reconstitution Inflammatory Syndrome of Tuberculous Lymphadenitis Successfully Treated with Corticosteroids. ( 28883243 )
2017
24
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )
2017
25
Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. ( 28740952 )
2017
26
Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice. ( 28739769 )
2017
27
Comparison of Endoscopic Ultrasonography Guided Biliary Drainage and Percutaneous Transhepatic Biliary Drainage in the Management of Malignant Obstructive Jaundice After Failed ERCP. ( 29206804 )
2017
28
Fine-needle aspiration findings of a rare hematopoietic neoplasm presenting as obstructive jaundice. ( 28752676 )
2017
29
Multi-modality imaging-monitored creation of rat orthotopic pancreatic head cancer with obstructive jaundice. ( 28903340 )
2017
30
Identification of bile survivin and carbohydrate antigen 199 in distinguishing cholangiocarcinoma from benign obstructive jaundice. ( 27874286 )
2017
31
Lemmel's syndrome: Obstructive jaundice secondary to a duodenal diverticulum. ( 28341217 )
2017
32
Clinical Interpretation of Elevated CA 19-9 Levels in Obstructive Jaundice Following Benign and Malignant Pancreatobiliary Disease. ( 28830135 )
2017
33
Simvastatin augments activation of liver regeneration through attenuating transforming growth factor-I^1 induced-apoptosis in obstructive jaundice rats. ( 29201188 )
2017
34
Embryonal rhabdomyosarcoma of the biliary tree: A rare cause of obstructive jaundice in children which can mimic choledochal cysts. ( 29089679 )
2017
35
Pseudohyponatraemia secondary to hyperlipidaemia in obstructive jaundice. ( 29196308 )
2017
36
Hepatobiliary and Pancreatic: Ruptured aneurysm of intra-hepatic portal vein causing obstructive jaundice. ( 28948704 )
2017
37
Primary extrahepatic bile duct neuroendocrine tumor with obstructive jaundice masquerading as a Klatskin tumor. ( 28596824 )
2017
38
Endoscopic ultrasound for the diagnosis of an uncommon cause of obstructive jaundice masquerading as malignancy. ( 28663532 )
2017
39
Current Status of Percutaneous Transhepatic Biliary Drainage in Palliation of Malignant Obstructive Jaundice: A Review. ( 27803558 )
2016
40
Value of percutaneous transhepatic cholangiobiopsy for pathologic diagnosis of obstructive jaundice: analysis of 826 cases. ( 26917786 )
2016
41
Combined Stent Insertion and High-intensity Focused Ultrasound Ablation for Patients With Malignant Obstructive Jaundice. ( 27783026 )
2016
42
Bile acid receptor TGR5 overexpression is associated with decreased intestinal mucosal injury and epithelial cell proliferation in obstructive jaundice. ( 28034761 )
2016
43
Obstructive Jaundice as a Complication of Macrocystic Serous Cystadenoma of the Pancreas. ( 27550882 )
2016
44
Temporary placement of a covered duodenal stent can avoid riskier anterograde biliary drainage when ERCP for obstructive jaundice fails due to duodenal invasion. ( 27324333 )
2016
45
Ginsenoside Rg1 prevents cerebral and cerebellar injury induced by obstructive jaundice in rats via inducing expression of TIPE-2. ( 26592478 )
2016
46
A pilot study of intraluminal brachytherapy using (125)I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice. ( 27364870 )
2016
47
The role of growth factors on hepatic damage in rats with obstructive jaundice. ( 27540507 )
2016
48
An interesting case of obstructive jaundice. ( 27728263 )
2016
49
Comparison Of Ultrasound Evaluation Of Patients Of Obstructive Jaundice With Endoscopic Retrograde Cholangio-Pancreatography Findings. ( 28586609 )
2016
50
The protective effects of pomegranate on liver and remote organs caused by experimental obstructive jaundice model. ( 26957283 )
2016

Variations for Obstructive Jaundice

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 ALB F2 GGT1 IL6 TNF
2 11.83 ALB ALPP HGF IL6
3 11.82 CD79A IL6 TNF
4 11.78 EDN1 IL6 TNF
5 11.73 CXCL8 HGF IL6 TNF
6 11.72 CXCL8 IL6 TNF
7 11.71 ALPP CD79A IL6
8 11.67 CXCL8 IL6 TNF
9 11.62 CXCL8 EDN1 IL6 TNF
10 11.58 CXCL8 IL6 TNF
11
Show member pathways
11.49 CXCL8 IL6 TNF
12 11.41 CXCL8 IL6 TNF
13 11.32 CXCL8 IL6 TNF
14 11.25 ALB F2 TTR
15 11.01 CXCL8 HGF IL6 TNF
16 10.95 CXCL8 HGF IL6 TNF
17 10.82 CXCL8 EDN1 HGF IL6 TNF
18 10.71 CXCL8 IL6 TNF

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ALB CXCL8 EDN1 F2 HGF IL6
2 extracellular space GO:0005615 9.36 ALB CXCL8 EDN1 F2 GGT1 GPT

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.56 ALB F2 IL6 TTR
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.54 EDN1 IL6 TNF
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.33 EDN1 IL6 TNF
4 negative regulation of lipid storage GO:0010888 9.32 IL6 TNF
5 regulation of receptor activity GO:0010469 9.17 CXCL8 EDN1 F2 HGF IL6 TNF
6 positive regulation of STAT protein import into nucleus GO:2000366 8.96 F2 IL6

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 EDN1 IL6 TNF

Sources for Obstructive Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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