MCID: OBS001
MIFTS: 50

Obstructive Jaundice malady

Summaries for Obstructive Jaundice

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to acute pancreatitis and tuberculosis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds cysteinylglycine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

obstructive jaundice 8
obstructive hyperbilirubinemia 8
cholestatic jaundice syndrome 8
obstructive jaundice nos 8
jaundice, obstructive 61
cholestatic jaundice 8
jaundice obstructive 45
jaundice cholestatic 45


External Ids:

Disease Ontology8 DOID:13603
MeSH35 D041781
NCIt40 C34742

Related Diseases for Obstructive Jaundice

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis30.8SCT, LBP
2tuberculosis30.7SRF
3adenocarcinoma30.7UCP2, SCT, CLDN4, ABCC3, GGT1, SRF
4adenoma30.5CEACAM1, GGT1, CLDN4, SCT
5hepatitis c30.4CCL20, GGT1
6colorectal cancer30.2ALPP, CEACAM1, ABCC3
7viral hepatitis30.2GGT1
8hypophosphatasia30.1ALPP
9choledocholithiasis30.0ALPP, GGT1
10hypophosphatemia30.0ALPP
11intrahepatic cholestasis30.0ALPP, GGT1, SCT
12atherosclerosis30.0UCP2, GGT1, SRF
13ulcerative colitis30.0CCL20, LBP, ITGAX, BLVRB, SRF
14cystadenoma10.5
15choledochal cyst10.4
16polycystic liver disease10.4
17acute leukemia10.3
18autoimmune pancreatitis10.3
19hepatitis d10.3
20secondary syphilis10.3
21hepatitis a10.3
22syphilis10.3
23lutz richner landolt syndrome10.3
24neurofibromatosis10.2
25acute myeloid leukemia10.2
26cryptococcosis10.2
27bile duct carcinoma10.2
28biliary tract disease10.2
29annular pancreas10.2
30mirizzi syndrome10.2
31ascariasis10.2
32fanconi syndrome10.2
33ovarian lymphoma10.2
34portal hypertension10.2
35eosinophilic gastroenteritis10.2
36hepatorenal syndrome10.2
37myeloid sarcoma10.2
38extramedullary plasmacytoma10.2
39n syndrome10.2
40papillary adenoma10.2
41abdominal tuberculosis10.2
42bile duct adenocarcinoma10.2
43bile duct adenoma10.2
44bile duct disease10.2
45hypercholesterolemia10.2
46pancreatitis, chronic10.2
47teratoma10.2
48infantile refsum disease10.1
49refsum disease10.1
50plasmodium vivax malaria10.1

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Clinical Features for Obstructive Jaundice

Drugs & Therapeutics for Obstructive Jaundice

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Obstructive Jaundice

Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Search CenterWatch for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

Anatomical Context for Obstructive Jaundice

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Obstructive Jaundice:

33
Ovary, Liver, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Thymus, Heart, Skeletal muscle, Small intestine, Pancreas, Breast, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Appendix, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Obstructive Jaundice:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9CEACAM1, SCT, LBP, CLDN4, ABCC3, TTR

Publications for Obstructive Jaundice

Sources:
51PubMed
See all sources

Articles related to Obstructive Jaundice:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Isolated hepatobiliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent child: case report and review of the literature. (23942746)
2013
2
Malignant obstructive jaundice - brachytherapy as a tool for palliation. (23878552)
2013
3
The effect of ursodeoxycholic acid in liver functional restoration of patients with obstructive jaundice after endoscopic treatment: a prospective, randomized, and controlled study. (24053627)
2013
4
Caution in interpretation of the tumor marker CA 19.9 in patients with obstructive jaundice: illustrative case reports. (23767270)
2013
5
Metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. (23354351)
2013
6
Obstructive jaundice secondary to liver hilar lymph node tuberculosis]. (22817998)
2013
7
A comparative analysis of nasogastric and intravenous fluid resuscitation in patients with malignant obstructive jaundice prior to endoscopic biliary drainage. (24251269)
2013
8
The effects of pomegranate on bacterial translocation in rats with obstructive jaundice. (23771537)
2013
9
Obstructive jaundice as an initial manifestation of non-hodgkin lymphoma: treatment dilemma and high mortality. (23818904)
2013
10
Portal vein aneurysm presenting with obstructive jaundice. (23029637)
2012
11
Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice. (22505378)
2012
12
One-step percutaneous transhepatic insertion of a balloon-expanding metallic stent for obstructive jaundice. (21649728)
2011
13
Obstructive jaundice caused by Clonorchiasis-associated duodenal papillitis: a case report. (21218042)
2011
14
What is appropriate procedure for preoperative biliary drainage in patients with obstructive jaundice awaiting pancreaticoduodenectomy? (22002271)
2011
15
Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report. (21722379)
2011
16
An unusual case of recurrent obstructive jaundice. (21447313)
2011
17
Limy bile syndrome complicated by obstructive jaundice. (20480840)
2010
18
Endoscopic biliary stenting successfully managed mucus obstructive jaundice in intraductal papillary mucinous carcinoma. (20195967)
2010
19
Schwannoma of common bile duct causing obstructive jaundice. (23133289)
2010
20
Obstructive jaundice caused by a portal cavernoma. (21191741)
2010
21
Obstructive jaundice in neonates. (20426278)
2009
22
Feasibility of combined EUS-FNA and ERCP for obstructive jaundice from presumed pancreatic malignancy. (19204740)
2009
23
Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. (19642836)
2009
24
Coagulation dynamics and platelet functions in obstructive jaundiced patients. (19646016)
2009
25
Biliary Cystadenoma Causing Obstructive Jaundice: Case Report and Literature Review. (21103240)
2009
26
Liver hemangioma complicated by obstructive jaundice. (18519125)
2008
27
The effects of combined use of glutamine and growth hormone on the bacterial translocation associated with obstructive jaundice. (18626527)
2008
28
Gastroduodenal artery pseudoaneurysm associated with hemosuccus pancreaticus and obstructive jaundice. (17634764)
2007
29
Myeloid sarcoma of the extrahepatic bile ducts presenting as obstructive jaundice. (16948823)
2006
30
Xanthogranulomatous cholangitis causing obstructive jaundice: a case report. (16865792)
2006
31
Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice. (16809227)
2006
32
Brain oxidative stress induced by obstructive jaundice in rats. (16462210)
2006
33
Randomized clinical trial of the effect of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. (15521079)
2005
34
Obstructive jaundice in a child with pancreatic hemangioma. (16047179)
2005
35
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. (15625352)
2005
36
Hypereosinophilic syndrome with hepatobiliary masses and obstructive jaundice. (15702811)
2005
37
Repeated obstructive jaundice and acute pancreatitis caused by metastatic liver tumor: an unusual case. (15783035)
2005
38
An uncommon complication of liver biopsy: obstructive jaundice from blood clots. (16821524)
2005
39
Obstructive jaundice: an unusual presentation of a superior mesenteric artery aneurysm. (15129880)
2004
40
HDR-192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice. (15526374)
2004
41
Magnetic resonance cholangiopancreatography: is it becoming the study of choice for evaluating obstructive jaundice? (15492597)
2004
42
Portal vein thrombosis, a cause of obstructive jaundice. (14988849)
2004
43
Obstructive jaundice caused by primary choledochal hydatid cyst mimicking radiologically choledochal cyst. (12596118)
2003
44
Profile of hepatocyte growth factor in patients with obstructive jaundice. (14696449)
2003
45
Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage. (10764720)
2000
46
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
47
Mirizzi syndrome: A rare cause of obstructive jaundice. (10436356)
1999
48
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
49
Peutz-Jeghers syndrome causing obstructive jaundice due to polyp in common bile duct. (6887190)
1983
50
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975

Genetic Variations for Obstructive Jaundice

Expression for genes affiliated with Obstructive Jaundice

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for genes affiliated with Obstructive Jaundice

Sources:
54Reactome, 52QIAGEN, 30KEGG
See all sources

Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CCL25, CCL20, CCL27
2
Hide members
10.2SRF, CCL27, CCL20, CCL25
3
Hide members
10.1ABCC3, KHK, GGT1, ASAH2, FUT4, ALPP
4
Hide members
10.1SRF, CLDN4, ITGAX, CCL27, CCL20, CCL25

Compounds for genes affiliated with Obstructive Jaundice

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1cysteinylglycine45 2411.7TTR, GGT1
2cycloheximide4510.7ITGAX, CEACAM1, ALPP
3ursodeoxycholic acid45 11 2412.7SCT, ABCC3, GGT1, ALPP
4bezafibrate45 29 1112.7ALPP, GGT1, UCP2
5rantes4510.7CCL20, SCT
6phosphorus4510.7ALPP, GGT1, TTR
7heparin45 29 11 2413.7SRF, LBP
8diflunisal45 1111.6ALPP, TTR
9glucose4510.6UCP2, SCT, SRF, CEACAM1
10peptidoglycan45 2911.6SRF, LBP, CCL20
11thyroxine45 2411.6UCP2, SCT, TTR, GGT1, ALPP
12sialic acid4510.6GGT1, SRF, FUT4, CEACAM1
13endotoxin4510.6CCL20, LBP, BLVRB, SRF
14vitamin b124510.6ALPP, GGT1, TTR
15indomethacin45 60 29 1113.6SCT, ITGAX, BLVRB, ABCC3, GGT1
16norepinephrine45 11 2412.6ALPP, SRF, TTR, SCT, UCP2
17arachidonic acid45 29 11 2413.6UCP2, LBP, ITGAX, SRF, ASAH2
18guanine45 11 2412.6SRF, GGT1, TTR, SCT
19phenobarbital45 29 1112.6ABCC3, GGT1, ALPP
20aspartate4510.6CCL27, SCT, LBP, TTR, GGT1, ALPP
21dopamine45 29 11 2413.6UCP2, SCT, BLVRB, TTR, GGT1
22uric acid45 2411.5TTR, GGT1, SRF
23carnitine4510.5UCP2, TTR, SRF
24creatinine4510.5CCL27, LBP, TTR, GGT1, SRF, ALPP
25lactate4510.5UCP2, TTR, GGT1, SRF, ALPP
26iron45 2411.5CCL20, BLVRB, TTR, GGT1, SRF
27superoxide45 2411.5UCP2, LBP, ITGAX, BLVRB, SRF
28vitamin-e4510.5GGT1, TTR, UCP2
29testosterone45 60 11 2413.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
30nitric oxide45 11 2412.5CCL20, UCP2, LBP, ITGAX, BLVRB, ABCC3
31dexamethasone45 50 29 1113.5ALPP, CCL20, CCL27, LBP, ABCC3, GGT1
32polysaccharide4510.5CEACAM1, FUT4, GGT1, LBP
33arginine4510.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
34cholesterol45 29 11 2413.4CCL27, UCP2, LBP, ABCC3, TTR, GGT1
35glutamate4510.4SCT, BLVRB, TTR, GGT1, SRF, ALPP
36fibrinogen4510.4LBP, ITGAX, TTR, SRF
37lipid4510.4CCL27, UCP2, SCT, LBP, ABCC3, GGT1
38phospholipid4510.4SRF, ABCC3, LBP, SCT
39atp45 2911.4UCP2, SCT, BLVRB, ABCC3, KHK, SRF
40retinoic acid45 2411.4UCP2, SCT, ITGAX, ABCC3, TTR, SRF
41catecholamine4510.4BLVRB, SCT, UCP2
42alanine4510.4CCL20, CCL27, UCP2, LBP, TTR, GGT1
43acetylcholine45 50 29 11 2414.3SCT, BLVRB, GGT1, SRF
44calcium45 50 11 2413.3CCL25, CCL20, CCL27, UCP2, SCT, BLVRB
45potassium45 11 2412.2GGT1, BLVRB, SCT, UCP2
46homocysteine45 2411.2SRF, TTR, LBP
47serine4510.2SCT, LBP, CLDN4, SRF, ALPP
48verapamil45 50 29 11 2414.0ABCC3, GGT1, ALPP

GO Terms for genes affiliated with Obstructive Jaundice

Sources:
16Gene Ontology
See all sources

Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CEACAM1, TTR, LBP, SCT, CCL27, CCL20

Biological processes related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.3CCL27, CCL20, CCL25

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3TTR, SCT, CCL25
2chemokine activityGO:00800910.0CCL27, CCL20, CCL25

Products for genes affiliated with Obstructive Jaundice

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Obstructive Jaundice

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet