MCID: OBS001
MIFTS: 50

Obstructive Jaundice malady

Gastrointestinal diseases category

Summaries for Obstructive Jaundice

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MalaCards based summary: Obstructive Jaundice, also known as cholestatic jaundice syndrome, is related to pancreatitis and pancreatic cancer. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways is Selected targets of CREB1. The compounds epft and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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Sources:
9Disease Ontology, 44Novoseek, 61UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Obstructive Jaundice, Aliases & Descriptions:

Name: Obstructive Jaundice 9
Cholestatic Jaundice Syndrome 9 61
Obstructive Hyperbilirubinaemia 61
Obstructive Hyperbilirubinemia 9
Obstructive Jaundice Nos 9
 
Jaundice, Obstructive 61
Jaundice Cholestatic 44
Jaundice Obstructive 44
Cholestatic Jaundice 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:13603
NCIt39 C34742
MeSH34 D041781

Related Diseases for Obstructive Jaundice

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Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Symptoms for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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MalaCards organs/tissues related to Obstructive Jaundice:

32
Liver, Pancreas, Lung, Brain, Myeloid, Lymph node, B cells, Neutrophil, Bone marrow, Bone, Spleen, Testes, T cells, Thymus, Heart, Skeletal muscle, Small intestine, Kidney, Breast, Ovary, Prostate, Monocytes, Endothelial, Appendix, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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MGI Mouse Phenotypes related to Obstructive Jaundice:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6SLC17A5, KHK, CCK, REN, ASAH2, TTR

Publications for Obstructive Jaundice

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Articles related to Obstructive Jaundice:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Percutaneous transhepatic cholangiobiopsy to determine the pathological cause of anastomotic stenosis after cholangiojejunostomy for malignant obstructive jaundice. (24156795)
2014
2
Obstructive jaundice due to von Hippel-Lindau disease-associated pancreatic lesions: A case report. (24959293)
2014
3
A case of obstructive jaundice caused by tuberculous lymphadenitis: a literature review. (25032188)
2014
4
Acute pancreatitis and obstructive jaundice as initial complaints of hepatocellular carcinoma: case report. (24422982)
2014
5
Acute obstructive jaundice: a possible clinical manifestation of IPMT. Case report and review of the literature. (25263694)
2014
6
Isolated hepatobiliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent child: case report and review of the literature. (23942746)
2013
7
A patient with obstructive jaundice. (23462120)
2013
8
Transjugular insertion of bare-metal biliary stent for the treatment of distal malignant obstructive jaundice complicated by coagulopathy. (22864606)
2013
9
Obstructive jaundice secondary to multiple hepatic artery aneurysms in a 14-year-old boy with neurofibromatosis type 1. (23602432)
2013
10
The use of antiendotoxin peptides in obstructive jaundice endotoxemia. (22246330)
2012
11
A new model of reversible obstructive jaundice using rapidly absorbable suture materials. (23217560)
2012
12
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
13
Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis. (19823116)
2010
14
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain. (19295251)
2009
15
An unusual cause of obstructive jaundice. (21686538)
2009
16
Tubulovillous adenoma in the common bile duct causing obstructive jaundice. (20163042)
2009
17
Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. (19630464)
2009
18
Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial clinical results. (19393505)
2009
19
Education and imaging. Hepatobiliary and pancreatic: Large cavernous hemangioma with obstructive jaundice. (19646022)
2009
20
Preoperative biliary drainage for obstructive jaundice. (18677779)
2008
21
Liver hemangioma complicated by obstructive jaundice. (18519125)
2008
22
Obstructive jaundice caused by bile duct involvement in intra-abdominal non-Hodgkin lymphoma: An unusual initial manifestation. (17439827)
2007
23
Effects of Danshen injection on the malignant obstructive jaundice in the SD rat model. (17357489)
2006
24
Effect of percutaneous biliary drainage on serum levels of tumor markers in patients with obstructive jaundice. (16995447)
2006
25
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
26
Therapeutic considerations in obstructive jaundice due to hepatic artery aneurysm. (18333248)
2006
27
Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice. (16500417)
2006
28
Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. (17007033)
2006
29
Successful cystic fenestration for a macrocystic serous cystadenoma of the pancreas causing obstructive jaundice: report of a case. (16378203)
2006
30
The current standard of care in the periprocedural management of the patient with obstructive jaundice. (17132306)
2006
31
One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent. (16688837)
2006
32
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
33
Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. (15610447)
2005
34
Randomized clinical trial of the effect of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. (15521079)
2005
35
Evaluation of functional liver reserve in patients with obstructive jaundice undergoing hepatectomy. (15816473)
2005
36
Medical image. Ampullary mass and obstructive jaundice. (16286948)
2005
37
Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice. (16078295)
2005
38
Intestinal failure in obstructive jaundice. (15968746)
2005
39
The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice. (15129871)
2004
40
Three cases of small hepatocellular carcinoma presenting as obstructive jaundice. (18333040)
2004
41
Annular pancreas with obstructive jaundice: beware of underlying neoplasm. (12370545)
2002
42
The effect of recombinant growth hormone on intestinal anastomotic wound healing in rats with obstructive jaundice. (16378269)
2002
43
Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. (11354287)
2001
44
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
45
Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case. (8892023)
1996
46
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
47
Mirizzi syndrome: a rare cause of obstructive jaundice. (2058010)
1991
48
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
49
Obstructive jaundice caused by polycystic liver disease. (7403520)
1980
50
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975

Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

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Pathways for genes affiliated with Obstructive Jaundice

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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CCK, REN

Compounds for genes affiliated with Obstructive Jaundice

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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1epft4410.0SCT, CCK
2taurodeoxycholate4410.0CCK, SCT
3l-bpa4410.0CCK, SCT
4caerulein4410.0CCK, SCT
5pancreozymin4410.0SCT, CCK
6loxiglumide4410.0SCT, CCK
7lauric acid44 2911.0CCK, ASAH2
8cerulein4410.0SCT, CCK
9trypsinogen449.9SCT, CCK
10oxyntomodulin44 6010.9SCT, CCK
11metoclopramide44 50 1211.8REN, CCK
12ranitidine44 29 25 1212.8CCK, SCT
13glycyrrhizin44 2910.8REN, SLC17A5
14naltrexone44 29 50 1212.8SCT, SLC17A5
15diltiazem44 29 50 1212.7REN, CCK
16lactulose449.7CCK, SLC17A5
17thiamine44 3 25 1212.6TTR, SLC17A5
18pepsinogen449.6CCK, SCT, REN
19bromosulfophthalein449.5ABCC3, CCK
20acth449.5CCK, REN, SCT
21mk 57160 4410.5ABCC3, CCK
22digoxin44 60 50 25 1213.4SLC17A5, REN
23glycocholate449.4SLC17A5, ABCC3
24chloride449.4SLC17A5, SCT, REN
25c-peptide449.4SLC17A5, CCK, SCT
26omeprazole44 50 29 25 1213.2ABCC3, CCK, SCT
27taurocholate449.2CCK, SCT, ABCC3
28ezetimibe44 1210.2SLC17A5, ABCC3
29lamivudine44 50 1211.1ABCC3, SLC17A5
30vitamin b6449.1TTR, SLC17A5
31dopamine44 29 25 1212.1CCK, TTR, SCT, REN
32indomethacin44 29 60 1212.1REN, SCT, ABCC3
33thyroxine44 2510.1SLC17A5, REN, TTR, SCT
34epinephrine44 25 1211.0SLC17A5, REN, TTR, SCT
35verapamil44 29 50 25 1213.0ABCC3, SLC17A5, REN
36arginine449.0REN, SCT, TTR, CCK
37acetaminophen44 3 50 25 1212.9SLC17A5, CCK, ABCC3
38cyclosporin a44 29 6010.9TTR, SLC17A5, SCT, CCK
39glutamine448.9SLC17A5, CCK, TTR, SCT
40testosterone44 60 25 1211.9SCT, TTR, CCK, SLC17A5
41glutamate448.8TTR, SLC17A5, CCK, SCT
42phospholipid448.7SCT, ABCC3, SLC17A5
43dexamethasone44 50 29 1211.6ABCC3, REN, CCK, TTR
44ursodeoxycholic acid44 25 1210.6ABCC3, SCT, SLC17A5, CCK
45norepinephrine44 25 1210.5SLC17A5, CCK, REN, TTR, SCT
46glucose448.5TTR, REN, CCK, SLC17A5, SCT
47folate448.5CCK, SLC17A5, TTR, ABCC3
48retinoic acid44 259.4SCT, ABCC3, TTR, CCK
49atp44 299.2KHK, SCT, ABCC3, SLC17A5
50cholesterol44 29 25 1211.1CCK, ABCC3, TTR, REN, SLC17A5

GO Terms for genes affiliated with Obstructive Jaundice

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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6CCL25, CCK, REN, TTR
2extracellular regionGO:0055767.9CCL25, CCK, REN, TTR, SCT

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.6CCL25, CCK, TTR, SCT

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet