MCID: OBS001
MIFTS: 51

Obstructive Jaundice malady

Summaries for Obstructive Jaundice

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32MalaCards
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MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and hepatitis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds cysteinylglycine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

obstructive jaundice 8
obstructive hyperbilirubinemia 8
cholestatic jaundice syndrome 8
obstructive jaundice nos 8
jaundice, obstructive 60
cholestatic jaundice 8
jaundice obstructive 44
jaundice cholestatic 44


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Disease Ontology8 DOID:13603
MeSH34 D041781
NCIt39 C34742

Related Diseases for Obstructive Jaundice

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17GeneCards, 18GeneDecks
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Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.3SCT, GGT1, ALPP
2hepatitis31.1CCL27, TTR, GGT1, CEACAM1, ALPP
3hepatocellular carcinoma30.8CCL20, SCT, ABCC3, GGT1, SRF, CEACAM1
4acute pancreatitis30.8SCT, LBP
5tuberculosis30.7SRF
6adenocarcinoma30.7UCP2, SCT, CLDN4, ABCC3, GGT1, SRF
7pancreatic cancer30.6GGT1, ABCC3, CLDN4, SCT, UCP2, CCL20
8cholangitis30.6ALPP, GGT1
9melanoma30.5CCL20, SRF, ASAH2, CEACAM1
10adenoma30.5CEACAM1, GGT1, CLDN4, SCT
11cholangiocarcinoma30.4SCT, GGT1, ALPP
12myeloma30.4ALPP, CEACAM1
13leukemia30.4CCL20, ITGAX, ABCC3, TTR, SRF, FUT4
14hepatitis c30.2CCL20, GGT1
15cholestasis30.2ALPP, GGT1, ABCC3
16liver cirrhosis30.2SCT, TTR, GGT1
17colorectal cancer30.2ALPP, CEACAM1, ABCC3
18lung cancer30.2ALPP, CEACAM1, FUT4, SRF, ABCC3, LBP
19viral hepatitis30.1GGT1
20hypophosphatasia30.1ALPP
21peritonitis30.0LBP
22choledocholithiasis29.9ALPP, GGT1
23hypophosphatemia29.9ALPP
24intrahepatic cholestasis29.9ALPP, GGT1, SCT
25atherosclerosis29.9UCP2, GGT1, SRF
26ulcerative colitis29.9CCL20, LBP, ITGAX, BLVRB, SRF
27diabetes mellitus29.9UCP2, SCT, GGT1, ALPP
28intestinal obstruction10.7
29duodenitis10.5
30duodenal obstruction10.5
31cystadenoma10.4
32hepatitis a10.4
33liver disease10.4
34choledochal cyst10.3
35polycystic liver disease10.3
36neurofibroma10.3
37non-hodgkin lymphoma10.3
38burkitt's lymphoma10.3
39acute leukemia10.3
40cholecystitis10.3
41hodgkin's lymphoma10.3
42multiple myeloma10.3
43neonatal jaundice10.3
44plasmacytoma10.3
45secondary syphilis10.2
46syphilis10.2
47lutz richner landolt syndrome10.2
48neurofibromatosis10.2
49acute myeloid leukemia10.2
50gastroduodenitis10.2

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Clinical Features for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Obstructive Jaundice

Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Search CenterWatch for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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32MalaCards
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MalaCards organs/tissues related to Obstructive Jaundice:

32
Liver, Pancreas, Lung, Myeloid, Brain, Lymph node, B cells, T cells, Testes, Bone marrow, Bone, Spleen, Kidney, Appendix, Endothelial, Monocytes, Thymus, Heart, Prostate, Ovary, Breast, Skeletal muscle, Small intestine, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Obstructive Jaundice:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9CEACAM1, SCT, LBP, CLDN4, ABCC3, TTR

Publications for Obstructive Jaundice

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50PubMed
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Articles related to Obstructive Jaundice:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
A patient with obstructive jaundice. (23462120)
2013
2
Obstructive jaundice secondary to ampullary adenocarcinoma in neurofibromatosis type 1. (24426533)
2013
3
iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. (23579209)
2013
4
Etiology and epidemiology of obstructive jaundice in Continental Croatia. (23697262)
2013
5
GI bleeding and obstructive jaundice caused by osteoclast-like giant cell tumor of the head of the pancreas eroding into the duodenum. (24365040)
2013
6
Endoscopic ultrasonography in tandem with endoscopic retrograde cholangiopancreatography in the management of suspected distal obstructive jaundice. (23249605)
2013
7
Influence of obstructive jaundice on pharmacodynamics of rocuronium. (24147111)
2013
8
Association of preoperative obstructive jaundice with postoperative infectious complications following pancreaticoduodenectomy. (23933917)
2013
9
Intervention of TLR4 signal pathway cytokines in severe liver injury with obstructive jaundice in rats. (22562737)
2012
10
Comparison of clinical outcome and cost-effectiveness after various preoperative biliary drainage methods in periampullary cancer with obstructive jaundice. (22468097)
2012
11
Blunt pancreatic head hematoma as an infrequent cause of delayed obstructive jaundice. (19345544)
2012
12
Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice. (22882852)
2012
13
Transduodenal endosonography-guided biliary drainage and duodenal stenting for palliation of malignant obstructive jaundice and duodenal obstruction. (22406603)
2012
14
Effects of percutaneous transhepatic biliary drainage on renal function in patients with obstructive jaundice. (20690079)
2011
15
Morgagni hernia presenting as obstructive jaundice. (21317468)
2011
16
An unusual cause of acute obstructive jaundice in an HIV-infected patient. (21427435)
2011
17
Extramedullary duodenal plasmacytoma presenting with gastric outlet obstruction and painless jaundice. (22470749)
2010
18
Obstructive jaundice at the initial presentation in small-cell lung cancer. (23754881)
2010
19
Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. (19630464)
2009
20
Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial clinical results. (19393505)
2009
21
Painless obstructive jaundice secondary to a common bile duct abscess: a delayed sequela of cholecystectomy. (20052383)
2009
22
Effect of salvia miltiorrhizae on apoptosis and NF-kappaB p65 expression in the liver of rats with severe acute pancreatitis or obstructive jaundice. (19067778)
2009
23
Obstructive jaundice impedes hepatic microcirculation in mice. (19260494)
2008
24
Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice. (18494050)
2008
25
Superoxide radical formation in diverse organs of rats with experimentally induced obstructive jaundice. (18647488)
2008
26
Obstructive jaundice caused by bile duct involvement in intra-abdominal non-Hodgkin lymphoma: An unusual initial manifestation. (17439827)
2007
27
Amiodarone hepatotoxicity complicating obstructive jaundice due to ampullary cancer. (17690045)
2007
28
The effects of somatostatin and ursodeoxycholic acid in preventing the ischemic injury of the liver following Pringle maneuver in obstructive jaundice-rat model. (17419266)
2007
29
A benign cause of obstructive jaundice with von Hippel-Lindau disease. A case report and review of the literature. (17993732)
2007
30
Anti-TNF-alpha treatment and bile duct drainage restore cellular immunity and prevent tissue injury in experimental obstructive jaundice. (18179761)
2007
31
Predictors of mortality and morbidity in acute obstructive jaundice: implication of preventive measures. (17708248)
2007
32
X-linked hyper-IgM syndrome associated with poorly differentiated neuroendocrine tumor presenting as obstructive jaundice secondary to extensive adenopathy. (17436099)
2007
33
Acute myeloid leukemia presenting as obstructive jaundice caused by granulocytic sarcoma. (20485638)
2007
34
A rare case of ectopic pancreas in the ampulla of Vater presented with obstructive jaundice. (17343237)
2006
35
Nonparasitic solitary giant hepatic cyst causing obstructive jaundice was successfully treated with monoethanolamine oleate. (16755093)
2006
36
Sloughing of intraductal tumor thrombus of hepatocellular carcinoma after transcatheter chemoembolization causing obstructive jaundice and acute pancreatitis. (16567686)
2006
37
Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. (15610447)
2005
38
Intestinal failure in obstructive jaundice. (15968746)
2005
39
Evaluation of Pringle maneuver during liver resection in a rat model of surgical obstructive jaundice. (16036781)
2005
40
EUS-guided trucut biopsy in establishing autoimmune pancreatitis as the cause of obstructive jaundice. (15758927)
2005
41
Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes. (16336445)
2005
42
Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice. (16136290)
2005
43
Herniation through the foramen of Winslow presenting as obstructive jaundice. (15902477)
2005
44
Effects of obstructive jaundice on the peripheral nerve: an ultrastructural study in rats. (15263828)
2004
45
Obstructive jaundice in a patient with multiple myeloma. (15209639)
2004
46
Multiple stents in treatment of obstructive jaundice associated with Klatskin's tumor. (10470950)
1999
47
Hepatic cytokeratin changes in obstructive jaundice: before and after biliary drainage. (8869453)
1995
48
Growth failure and decreased levels of insulin-like growth factor I in obstructive jaundice are reversed by bile diversion. (1919980)
1991
49
Plasma retinol transport system and taste acuity in patients with obstructive jaundice. (2347474)
1990
50
An unusual clinical presentation of pancreatic carcinoma: Duodenal obstruction in the absence of jaundice. (1008050)
1976

Genetic Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for genes affiliated with Obstructive Jaundice

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53Reactome, 51QIAGEN, 29KEGG
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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CCL25, CCL20, CCL27
2
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10.2SRF, CCL27, CCL20, CCL25
3
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10.1ABCC3, KHK, GGT1, ASAH2, FUT4, ALPP
4
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10.1SRF, CLDN4, ITGAX, CCL27, CCL20, CCL25

Compounds for genes affiliated with Obstructive Jaundice

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1cysteinylglycine44 2411.7TTR, GGT1
2cycloheximide4410.7ITGAX, CEACAM1, ALPP
3ursodeoxycholic acid44 11 2412.7SCT, ABCC3, GGT1, ALPP
4bezafibrate44 28 1112.7ALPP, GGT1, UCP2
5rantes4410.7CCL20, SCT
6phosphorus4410.7ALPP, GGT1, TTR
7heparin44 28 11 2413.7SRF, LBP
8diflunisal44 1111.6ALPP, TTR
9glucose4410.6UCP2, SCT, SRF, CEACAM1
10peptidoglycan44 2811.6SRF, LBP, CCL20
11thyroxine44 2411.6UCP2, SCT, TTR, GGT1, ALPP
12sialic acid4410.6GGT1, SRF, FUT4, CEACAM1
13endotoxin4410.6CCL20, LBP, BLVRB, SRF
14vitamin b124410.6ALPP, GGT1, TTR
15indomethacin44 59 28 1113.6SCT, ITGAX, BLVRB, ABCC3, GGT1
16norepinephrine44 11 2412.6ALPP, SRF, TTR, SCT, UCP2
17arachidonic acid44 28 11 2413.6UCP2, LBP, ITGAX, SRF, ASAH2
18guanine44 11 2412.6SRF, GGT1, TTR, SCT
19phenobarbital44 28 1112.6ABCC3, GGT1, ALPP
20aspartate4410.6CCL27, SCT, LBP, TTR, GGT1, ALPP
21dopamine44 28 11 2413.6UCP2, SCT, BLVRB, TTR, GGT1
22uric acid44 2411.5TTR, GGT1, SRF
23carnitine4410.5UCP2, TTR, SRF
24creatinine4410.5CCL27, LBP, TTR, GGT1, SRF, ALPP
25lactate4410.5UCP2, TTR, GGT1, SRF, ALPP
26iron44 2411.5CCL20, BLVRB, TTR, GGT1, SRF
27superoxide44 2411.5UCP2, LBP, ITGAX, BLVRB, SRF
28vitamin-e4410.5GGT1, TTR, UCP2
29testosterone44 59 11 2413.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
30nitric oxide44 11 2412.5CCL20, UCP2, LBP, ITGAX, BLVRB, ABCC3
31dexamethasone44 49 28 1113.5ALPP, CCL20, CCL27, LBP, ABCC3, GGT1
32polysaccharide4410.5CEACAM1, FUT4, GGT1, LBP
33arginine4410.5SCT, BLVRB, TTR, GGT1, SRF, ALPP
34cholesterol44 28 11 2413.4CCL27, UCP2, LBP, ABCC3, TTR, GGT1
35glutamate4410.4SCT, BLVRB, TTR, GGT1, SRF, ALPP
36fibrinogen4410.4LBP, ITGAX, TTR, SRF
37lipid4410.4CCL27, UCP2, SCT, LBP, ABCC3, GGT1
38phospholipid4410.4SRF, ABCC3, LBP, SCT
39atp44 2811.4UCP2, SCT, BLVRB, ABCC3, KHK, SRF
40retinoic acid44 2411.4UCP2, SCT, ITGAX, ABCC3, TTR, SRF
41catecholamine4410.4BLVRB, SCT, UCP2
42alanine4410.4CCL20, CCL27, UCP2, LBP, TTR, GGT1
43acetylcholine44 49 28 11 2414.3SCT, BLVRB, GGT1, SRF
44calcium44 49 11 2413.3CCL25, CCL20, CCL27, UCP2, SCT, BLVRB
45potassium44 11 2412.2GGT1, BLVRB, SCT, UCP2
46homocysteine44 2411.2SRF, TTR, LBP
47serine4410.2SCT, LBP, CLDN4, SRF, ALPP
48verapamil44 49 28 11 2414.0ABCC3, GGT1, ALPP

GO Terms for genes affiliated with Obstructive Jaundice

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16Gene Ontology
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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CEACAM1, TTR, LBP, SCT, CCL27, CCL20

Biological processes related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.3CCL27, CCL20, CCL25

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3TTR, SCT, CCL25
2chemokine activityGO:00800910.0CCL27, CCL20, CCL25

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet