MCID: OBS001
MIFTS: 50

Obstructive Jaundice malady

Gastrointestinal diseases category

Summaries for Obstructive Jaundice

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34MalaCards
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MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and acute pancreatitis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways is Selected targets of CREB1. The compounds epft and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

obstructive jaundice 9
obstructive hyperbilirubinemia 9
cholestatic jaundice syndrome 9
obstructive jaundice nos 9
jaundice, obstructive 63
cholestatic jaundice 9
jaundice obstructive 46
jaundice cholestatic 46


External Ids:

Disease Ontology9 DOID:13603
MeSH36 D041781
NCIt41 C34742

Related Diseases for Obstructive Jaundice

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Symptoms for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Obstructive Jaundice

Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Search CenterWatch for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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34MalaCards
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MalaCards organs/tissues related to Obstructive Jaundice:

34
Liver, Pancreas, Lung, Myeloid, Brain, Lymph node, B cells, T cells, Testes, Bone marrow, Bone, Spleen, Kidney, Appendix, Endothelial, Monocytes, Thymus, Heart, Prostate, Ovary, Breast, Skeletal muscle, Small intestine, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Obstructive Jaundice:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6SLC17A5, KHK, CCK, REN, ASAH2, TTR

Publications for Obstructive Jaundice

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53PubMed
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Articles related to Obstructive Jaundice:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Percutaneous transhepatic cholangiobiopsy to determine the pathological cause of anastomotic stenosis after cholangiojejunostomy for malignant obstructive jaundice. (24156795)
2014
2
Acute pancreatitis and obstructive jaundice as initial complaints of hepatocellular carcinoma: case report. (24422982)
2014
3
Isolated hepatobiliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent child: case report and review of the literature. (23942746)
2013
4
A patient with obstructive jaundice. (23462120)
2013
5
Transjugular insertion of bare-metal biliary stent for the treatment of distal malignant obstructive jaundice complicated by coagulopathy. (22864606)
2013
6
Obstructive jaundice secondary to multiple hepatic artery aneurysms in a 14-year-old boy with neurofibromatosis type 1. (23602432)
2013
7
The use of antiendotoxin peptides in obstructive jaundice endotoxemia. (22246330)
2012
8
A new model of reversible obstructive jaundice using rapidly absorbable suture materials. (23217560)
2012
9
Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. (22100509)
2012
10
Extravascular hemolysis mimicking severe obstructive jaundice. (23103421)
2012
11
Portal vein aneurysm presenting with obstructive jaundice. (23029637)
2012
12
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
13
Neurofibroma of the common bile duct: a rare cause of obstructive jaundice. (21741514)
2011
14
Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis. (19823116)
2010
15
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain. (19295251)
2009
16
An unusual cause of obstructive jaundice. (21686538)
2009
17
Tubulovillous adenoma in the common bile duct causing obstructive jaundice. (20163042)
2009
18
Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. (19630464)
2009
19
Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial clinical results. (19393505)
2009
20
Education and imaging. Hepatobiliary and pancreatic: Large cavernous hemangioma with obstructive jaundice. (19646022)
2009
21
Preoperative biliary drainage for obstructive jaundice. (18677779)
2008
22
Liver hemangioma complicated by obstructive jaundice. (18519125)
2008
23
Obstructive jaundice caused by bile duct involvement in intra-abdominal non-Hodgkin lymphoma: An unusual initial manifestation. (17439827)
2007
24
Effects of Danshen injection on the malignant obstructive jaundice in the SD rat model. (17357489)
2006
25
Effect of percutaneous biliary drainage on serum levels of tumor markers in patients with obstructive jaundice. (16995447)
2006
26
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
27
Therapeutic considerations in obstructive jaundice due to hepatic artery aneurysm. (18333248)
2006
28
Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice. (16500417)
2006
29
Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. (17007033)
2006
30
Successful cystic fenestration for a macrocystic serous cystadenoma of the pancreas causing obstructive jaundice: report of a case. (16378203)
2006
31
The current standard of care in the periprocedural management of the patient with obstructive jaundice. (17132306)
2006
32
One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent. (16688837)
2006
33
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
34
Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. (15610447)
2005
35
Randomized clinical trial of the effect of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. (15521079)
2005
36
Evaluation of functional liver reserve in patients with obstructive jaundice undergoing hepatectomy. (15816473)
2005
37
Medical image. Ampullary mass and obstructive jaundice. (16286948)
2005
38
Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice. (16078295)
2005
39
Intestinal failure in obstructive jaundice. (15968746)
2005
40
The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice. (15129871)
2004
41
Three cases of small hepatocellular carcinoma presenting as obstructive jaundice. (18333040)
2004
42
Annular pancreas with obstructive jaundice: beware of underlying neoplasm. (12370545)
2002
43
The effect of recombinant growth hormone on intestinal anastomotic wound healing in rats with obstructive jaundice. (16378269)
2002
44
Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. (11354287)
2001
45
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
46
Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case. (8892023)
1996
47
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
48
Mirizzi syndrome: a rare cause of obstructive jaundice. (2058010)
1991
49
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
50
Obstructive jaundice caused by polycystic liver disease. (7403520)
1980

Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

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Pathways for genes affiliated with Obstructive Jaundice

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51PathCards, 13EMD Millipore
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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CCK, REN

Compounds for genes affiliated with Obstructive Jaundice

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1epft4610.0SCT, CCK
2taurodeoxycholate4610.0SCT, CCK
3l-bpa4610.0SCT, CCK
4caerulein4610.0CCK, SCT
5pancreozymin4610.0CCK, SCT
6loxiglumide4610.0SCT, CCK
7cerulein4610.0SCT, CCK
8lauric acid46 3011.0CCK, ASAH2
9trypsinogen469.9CCK, SCT
10oxyntomodulin46 6210.9CCK, SCT
11metoclopramide46 52 1211.8CCK, REN
12ranitidine46 30 25 1212.8SCT, CCK
13glycyrrhizin46 3010.8SLC17A5, REN
14naltrexone46 30 52 1212.8SLC17A5, SCT
15diltiazem46 30 52 1212.7CCK, REN
16lactulose469.7CCK, SLC17A5
17thiamine46 3 25 1212.6TTR, SLC17A5
18pepsinogen469.6CCK, REN, SCT
19bromosulfophthalein469.5ABCC3, CCK
20acth469.5SCT, REN, CCK
21mk 57162 4610.5CCK, ABCC3
22digoxin46 62 52 25 1213.4SLC17A5, REN
23glycocholate469.4SLC17A5, ABCC3
24chloride469.4SCT, REN, SLC17A5
25c-peptide469.4SLC17A5, CCK, SCT
26omeprazole46 52 30 25 1213.2CCK, SCT, ABCC3
27taurocholate469.2CCK, SCT, ABCC3
28ezetimibe46 1210.2ABCC3, SLC17A5
29lamivudine46 52 1211.1SLC17A5, ABCC3
30vitamin b6469.1SLC17A5, TTR
31dopamine46 30 25 1212.1SCT, TTR, REN, CCK
32indomethacin46 30 62 1212.1REN, SCT, ABCC3
33thyroxine46 2510.1SLC17A5, REN, TTR, SCT
34epinephrine46 25 1211.0SCT, TTR, REN, SLC17A5
35verapamil46 30 52 25 1213.0SLC17A5, REN, ABCC3
36arginine469.0SCT, TTR, REN, CCK
37acetaminophen46 3 52 25 1212.9SLC17A5, CCK, ABCC3
38cyclosporin a46 30 6210.9SCT, TTR, CCK, SLC17A5
39glutamine468.9SCT, TTR, CCK, SLC17A5
40testosterone46 62 25 1211.9SCT, TTR, CCK, SLC17A5
41glutamate468.8SCT, TTR, CCK, SLC17A5
42phospholipid468.7ABCC3, SCT, SLC17A5
43dexamethasone46 52 30 1211.6CCK, REN, TTR, ABCC3
44ursodeoxycholic acid46 25 1210.6SLC17A5, CCK, SCT, ABCC3
45norepinephrine46 25 1210.5SCT, TTR, REN, CCK, SLC17A5
46glucose468.5SCT, TTR, REN, CCK, SLC17A5
47folate468.5ABCC3, TTR, CCK, SLC17A5
48retinoic acid46 259.4CCK, TTR, SCT, ABCC3
49atp46 309.2SLC17A5, KHK, SCT, ABCC3
50cholesterol46 30 25 1211.1SLC17A5, CCK, REN, TTR, ABCC3

GO Terms for genes affiliated with Obstructive Jaundice

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17Gene Ontology
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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6CCL25, CCK, REN, TTR
2extracellular regionGO:0055767.9CCL25, CCK, REN, TTR, SCT

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.6CCL25, CCK, TTR, SCT

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet