MCID: OBS001
MIFTS: 50

Obstructive Jaundice malady

Gastrointestinal diseases category
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Summaries for Obstructive Jaundice

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33MalaCards
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MalaCards: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and acute pancreatitis. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways is Selected targets of CREB1. The compounds epft and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

obstructive jaundice 8
obstructive hyperbilirubinemia 8
cholestatic jaundice syndrome 8
obstructive jaundice nos 8
jaundice, obstructive 62
cholestatic jaundice 8
jaundice obstructive 45
jaundice cholestatic 45


External Ids:

Disease Ontology8 DOID:13603
MeSH35 D041781
NCIt40 C34742

Related Diseases for Obstructive Jaundice

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Symptoms for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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33MalaCards
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MalaCards organs/tissues related to Obstructive Jaundice:

33
Liver, Pancreas, Lung, Myeloid, Brain, Lymph node, B cells, T cells, Testes, Bone marrow, Bone, Spleen, Kidney, Appendix, Endothelial, Monocytes, Thymus, Heart, Prostate, Ovary, Breast, Skeletal muscle, Small intestine, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Obstructive Jaundice:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6SLC17A5, KHK, CCK, REN, ASAH2, TTR

Publications for Obstructive Jaundice

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52PubMed
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Articles related to Obstructive Jaundice:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Percutaneous transhepatic cholangiobiopsy to determine the pathological cause of anastomotic stenosis after cholangiojejunostomy for malignant obstructive jaundice. (24156795)
2014
2
Acute pancreatitis and obstructive jaundice as initial complaints of hepatocellular carcinoma: case report. (24422982)
2014
3
Isolated hepatobiliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent child: case report and review of the literature. (23942746)
2013
4
A patient with obstructive jaundice. (23462120)
2013
5
Transjugular insertion of bare-metal biliary stent for the treatment of distal malignant obstructive jaundice complicated by coagulopathy. (22864606)
2013
6
Obstructive jaundice secondary to multiple hepatic artery aneurysms in a 14-year-old boy with neurofibromatosis type 1. (23602432)
2013
7
The use of antiendotoxin peptides in obstructive jaundice endotoxemia. (22246330)
2012
8
A new model of reversible obstructive jaundice using rapidly absorbable suture materials. (23217560)
2012
9
Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. (22100509)
2012
10
Extravascular hemolysis mimicking severe obstructive jaundice. (23103421)
2012
11
Portal vein aneurysm presenting with obstructive jaundice. (23029637)
2012
12
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
13
Neurofibroma of the common bile duct: a rare cause of obstructive jaundice. (21741514)
2011
14
Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis. (19823116)
2010
15
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain. (19295251)
2009
16
An unusual cause of obstructive jaundice. (21686538)
2009
17
Tubulovillous adenoma in the common bile duct causing obstructive jaundice. (20163042)
2009
18
Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. (19630464)
2009
19
Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial clinical results. (19393505)
2009
20
Education and imaging. Hepatobiliary and pancreatic: Large cavernous hemangioma with obstructive jaundice. (19646022)
2009
21
Preoperative biliary drainage for obstructive jaundice. (18677779)
2008
22
Liver hemangioma complicated by obstructive jaundice. (18519125)
2008
23
Obstructive jaundice caused by bile duct involvement in intra-abdominal non-Hodgkin lymphoma: An unusual initial manifestation. (17439827)
2007
24
Effects of Danshen injection on the malignant obstructive jaundice in the SD rat model. (17357489)
2006
25
Effect of percutaneous biliary drainage on serum levels of tumor markers in patients with obstructive jaundice. (16995447)
2006
26
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
27
Therapeutic considerations in obstructive jaundice due to hepatic artery aneurysm. (18333248)
2006
28
Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice. (16500417)
2006
29
Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. (17007033)
2006
30
Successful cystic fenestration for a macrocystic serous cystadenoma of the pancreas causing obstructive jaundice: report of a case. (16378203)
2006
31
The current standard of care in the periprocedural management of the patient with obstructive jaundice. (17132306)
2006
32
One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent. (16688837)
2006
33
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
34
Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. (15610447)
2005
35
Randomized clinical trial of the effect of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. (15521079)
2005
36
Evaluation of functional liver reserve in patients with obstructive jaundice undergoing hepatectomy. (15816473)
2005
37
Medical image. Ampullary mass and obstructive jaundice. (16286948)
2005
38
Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice. (16078295)
2005
39
Intestinal failure in obstructive jaundice. (15968746)
2005
40
The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice. (15129871)
2004
41
Three cases of small hepatocellular carcinoma presenting as obstructive jaundice. (18333040)
2004
42
Annular pancreas with obstructive jaundice: beware of underlying neoplasm. (12370545)
2002
43
The effect of recombinant growth hormone on intestinal anastomotic wound healing in rats with obstructive jaundice. (16378269)
2002
44
Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. (11354287)
2001
45
Obstructive jaundice and acute cholangitis due to papillary stenosis. (10333725)
1999
46
Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case. (8892023)
1996
47
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
48
Mirizzi syndrome: a rare cause of obstructive jaundice. (2058010)
1991
49
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
50
Obstructive jaundice caused by polycystic liver disease. (7403520)
1980

Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Jaundice

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Pathways for genes affiliated with Obstructive Jaundice

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50PathCards, 12EMD Millipore
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Pathways related to Obstructive Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CCK, REN

Compounds for genes affiliated with Obstructive Jaundice

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Obstructive Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1epft4510.0SCT, CCK
2taurodeoxycholate4510.0SCT, CCK
3l-bpa4510.0SCT, CCK
4caerulein4510.0CCK, SCT
5pancreozymin4510.0CCK, SCT
6loxiglumide4510.0SCT, CCK
7cerulein4510.0SCT, CCK
8lauric acid45 2911.0CCK, ASAH2
9trypsinogen459.9CCK, SCT
10oxyntomodulin45 6110.9CCK, SCT
11metoclopramide45 51 1111.8CCK, REN
12ranitidine45 29 24 1112.8SCT, CCK
13glycyrrhizin45 2910.8SLC17A5, REN
14naltrexone45 29 51 1112.8SLC17A5, SCT
15diltiazem45 29 51 1112.7CCK, REN
16lactulose459.7CCK, SLC17A5
17thiamine45 3 24 1112.6TTR, SLC17A5
18pepsinogen459.6CCK, REN, SCT
19bromosulfophthalein459.5ABCC3, CCK
20acth459.5SCT, REN, CCK
21mk 57161 4510.5CCK, ABCC3
22digoxin45 61 51 24 1113.4SLC17A5, REN
23glycocholate459.4SLC17A5, ABCC3
24chloride459.4SCT, REN, SLC17A5
25c-peptide459.4SLC17A5, CCK, SCT
26omeprazole45 51 29 24 1113.2CCK, SCT, ABCC3
27taurocholate459.2CCK, SCT, ABCC3
28ezetimibe45 1110.2ABCC3, SLC17A5
29lamivudine45 51 1111.1SLC17A5, ABCC3
30vitamin b6459.1SLC17A5, TTR
31dopamine45 29 24 1112.1SCT, TTR, REN, CCK
32indomethacin45 29 61 1112.1REN, SCT, ABCC3
33thyroxine45 2410.1SLC17A5, REN, TTR, SCT
34epinephrine45 24 1111.0SCT, TTR, REN, SLC17A5
35verapamil45 29 51 24 1113.0SLC17A5, REN, ABCC3
36arginine459.0SCT, TTR, REN, CCK
37acetaminophen45 3 51 24 1112.9SLC17A5, CCK, ABCC3
38cyclosporin a45 29 6110.9SCT, TTR, CCK, SLC17A5
39glutamine458.9SCT, TTR, CCK, SLC17A5
40testosterone45 61 24 1111.9SCT, TTR, CCK, SLC17A5
41glutamate458.8SCT, TTR, CCK, SLC17A5
42phospholipid458.7ABCC3, SCT, SLC17A5
43dexamethasone45 51 29 1111.6CCK, REN, TTR, ABCC3
44ursodeoxycholic acid45 24 1110.6SLC17A5, CCK, SCT, ABCC3
45norepinephrine45 24 1110.5SCT, TTR, REN, CCK, SLC17A5
46glucose458.5SCT, TTR, REN, CCK, SLC17A5
47folate458.5ABCC3, TTR, CCK, SLC17A5
48retinoic acid45 249.4CCK, TTR, SCT, ABCC3
49atp45 299.2SLC17A5, KHK, SCT, ABCC3
50cholesterol45 29 24 1111.1SLC17A5, CCK, REN, TTR, ABCC3

GO Terms for genes affiliated with Obstructive Jaundice

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16Gene Ontology
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Cellular components related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6CCL25, CCK, REN, TTR
2extracellular regionGO:0055767.9CCL25, CCK, REN, TTR, SCT

Molecular functions related to Obstructive Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.6CCL25, CCK, TTR, SCT

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet