MCID: OBS001
MIFTS: 42

Obstructive Jaundice malady

Summaries for Obstructive Jaundice

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MalaCards based summary: Obstructive Jaundice, also known as obstructive hyperbilirubinemia, is related to pancreatitis and liver disease. An important gene associated with Obstructive Jaundice is ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), and among its related pathways is Selected targets of CREB1. The compounds epft and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Obstructive Jaundice

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Obstructive Jaundice, Aliases & Descriptions:

Name: Obstructive Jaundice 9
Obstructive Hyperbilirubinemia 9
Cholestatic Jaundice Syndrome 9
Obstructive Jaundice Nos 9
 
Jaundice, Obstructive 60
Cholestatic Jaundice 9
Jaundice Obstructive 43
Jaundice Cholestatic 43


External Ids:

Disease Ontology9 DOID:13603
NCIt38 C34742
MeSH33 D041781

Related Diseases for Obstructive Jaundice

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Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to obstructive jaundice

Symptoms for Obstructive Jaundice

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Drugs & Therapeutics for Obstructive Jaundice

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Drug clinical trials:

Search ClinicalTrials for Obstructive Jaundice

Search NIH Clinical Center for Obstructive Jaundice

Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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MalaCards organs/tissues related to Obstructive Jaundice:

31
Liver, Pancreas, Lung, Lymph node, Brain, Myeloid, B cells, Neutrophil, Bone marrow, Bone, Spleen, Testes, T cells, Thymus, Heart, Skeletal muscle, Small intestine, Breast, Ovary, Prostate, Monocytes, Endothelial, Appendix, Pituitary

Animal Models for Obstructive Jaundice or affiliated genes

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MGI Mouse Phenotypes related to Obstructive Jaundice:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6SLC17A5, KHK, CCK, REN, ASAH2, TTR

Publications for Obstructive Jaundice

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Articles related to Obstructive Jaundice:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Obstructive jaundice caused by a giant non-parasitic hepatic cyst. (25671837)
2015
2
Percutaneous transhepatic cholangiobiopsy to determine the pathological cause of anastomotic stenosis after cholangiojejunostomy for malignant obstructive jaundice. (24156795)
2014
3
Obstructive jaundice due to von Hippel-Lindau disease-associated pancreatic lesions: A case report. (24959293)
2014
4
A case of obstructive jaundice caused by tuberculous lymphadenitis: a literature review. (25032188)
2014
5
Acute pancreatitis and obstructive jaundice as initial complaints of hepatocellular carcinoma: case report. (24422982)
2014
6
Acute obstructive jaundice: a possible clinical manifestation of IPMT. Case report and review of the literature. (25263694)
2014
7
Isolated hepatobiliary cryptococcosis manifesting as obstructive jaundice in an immunocompetent child: case report and review of the literature. (23942746)
2013
8
A patient with obstructive jaundice. (23462120)
2013
9
Transjugular insertion of bare-metal biliary stent for the treatment of distal malignant obstructive jaundice complicated by coagulopathy. (22864606)
2013
10
Obstructive jaundice secondary to multiple hepatic artery aneurysms in a 14-year-old boy with neurofibromatosis type 1. (23602432)
2013
11
The use of antiendotoxin peptides in obstructive jaundice endotoxemia. (22246330)
2012
12
A new model of reversible obstructive jaundice using rapidly absorbable suture materials. (23217560)
2012
13
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
14
Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis. (19823116)
2010
15
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain. (19295251)
2009
16
An unusual cause of obstructive jaundice. (21686538)
2009
17
Tubulovillous adenoma in the common bile duct causing obstructive jaundice. (20163042)
2009
18
Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. (19630464)
2009
19
Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial clinical results. (19393505)
2009
20
Education and imaging. Hepatobiliary and pancreatic: Large cavernous hemangioma with obstructive jaundice. (19646022)
2009
21
Preoperative biliary drainage for obstructive jaundice. (18677779)
2008
22
Liver hemangioma complicated by obstructive jaundice. (18519125)
2008
23
Obstructive jaundice caused by bile duct involvement in intra-abdominal non-Hodgkin lymphoma: An unusual initial manifestation. (17439827)
2007
24
Effects of Danshen injection on the malignant obstructive jaundice in the SD rat model. (17357489)
2006
25
Effect of percutaneous biliary drainage on serum levels of tumor markers in patients with obstructive jaundice. (16995447)
2006
26
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
27
Therapeutic considerations in obstructive jaundice due to hepatic artery aneurysm. (18333248)
2006
28
Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice. (16500417)
2006
29
Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. (17007033)
2006
30
Successful cystic fenestration for a macrocystic serous cystadenoma of the pancreas causing obstructive jaundice: report of a case. (16378203)
2006
31
The current standard of care in the periprocedural management of the patient with obstructive jaundice. (17132306)
2006
32
One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent. (16688837)
2006
33
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
34
Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. (15610447)
2005
35
Randomized clinical trial of the effect of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. (15521079)
2005
36
Evaluation of functional liver reserve in patients with obstructive jaundice undergoing hepatectomy. (15816473)
2005
37
Medical image. Ampullary mass and obstructive jaundice. (16286948)
2005
38
Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice. (16078295)
2005
39
Intestinal failure in obstructive jaundice. (15968746)
2005
40
The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice. (15129871)
2004
41
Three cases of small hepatocellular carcinoma presenting as obstructive jaundice. (18333040)
2004
42
Annular pancreas with obstructive jaundice: beware of underlying neoplasm. (12370545)
2002
43
The effect of recombinant growth hormone on intestinal anastomotic wound healing in rats with obstructive jaundice. (16378269)
2002
44
Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. (11354287)
2001
45
Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case. (8892023)
1996
46
Choledocholithiasis causing obstructive jaundice 52 years after cholecystectomy. (7594174)
1995
47
Mirizzi syndrome: a rare cause of obstructive jaundice. (2058010)
1991
48
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
49
Obstructive jaundice caused by polycystic liver disease. (7403520)
1980
50
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975

Variations for Obstructive Jaundice

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Expression for genes affiliated with Obstructive Jaundice

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Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for genes affiliated with Obstructive Jaundice

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Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes

Compounds for genes affiliated with Obstructive Jaundice

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Compounds related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1epft4310.0SCT, CCK
2taurodeoxycholate4310.0CCK, SCT
3l-bpa4310.0CCK, SCT
4caerulein4310.0CCK, SCT
5pancreozymin4310.0SCT, CCK
6loxiglumide4310.0SCT, CCK
7lauric acid43 2811.0CCK, ASAH2
8cerulein4310.0SCT, CCK
9trypsinogen439.9SCT, CCK
10oxyntomodulin43 5910.9SCT, CCK
11metoclopramide43 49 1211.8REN, CCK
12ranitidine43 28 24 1212.8CCK, SCT
13glycyrrhizin43 2810.8REN, SLC17A5
14naltrexone43 28 49 1212.8SCT, SLC17A5
15diltiazem43 28 49 1212.7REN, CCK
16lactulose439.7CCK, SLC17A5
17thiamine43 2 24 1212.6TTR, SLC17A5
18pepsinogen439.6CCK, SCT, REN
19bromosulfophthalein439.5ABCC3, CCK
20acth439.5CCK, REN, SCT
21mk 57159 4310.5ABCC3, CCK
22digoxin43 59 49 24 1213.4SLC17A5, REN
23glycocholate439.4SLC17A5, ABCC3
24chloride439.4SLC17A5, SCT, REN
25c-peptide439.4SLC17A5, CCK, SCT
26omeprazole43 49 28 24 1213.2ABCC3, CCK, SCT
27taurocholate439.2CCK, SCT, ABCC3
28ezetimibe43 1210.2SLC17A5, ABCC3
29lamivudine43 49 1211.1ABCC3, SLC17A5
30vitamin b6439.1TTR, SLC17A5
31dopamine43 28 24 1212.1CCK, TTR, SCT, REN
32indomethacin43 28 59 1212.1REN, SCT, ABCC3
33thyroxine43 2410.1SLC17A5, REN, TTR, SCT
34epinephrine43 24 1211.0SLC17A5, REN, TTR, SCT
35verapamil43 28 49 24 1213.0ABCC3, SLC17A5, REN
36arginine439.0REN, SCT, TTR, CCK
37acetaminophen43 2 49 24 1212.9SLC17A5, CCK, ABCC3
38cyclosporin a43 28 5910.9TTR, SLC17A5, SCT, CCK
39glutamine438.9SLC17A5, CCK, TTR, SCT
40testosterone43 59 24 1211.9SCT, TTR, CCK, SLC17A5
41glutamate438.8TTR, SLC17A5, CCK, SCT
42phospholipid438.7SCT, ABCC3, SLC17A5
43dexamethasone43 49 28 1211.6ABCC3, REN, CCK, TTR
44ursodeoxycholic acid43 24 1210.6ABCC3, SCT, SLC17A5, CCK
45norepinephrine43 24 1210.5SLC17A5, CCK, REN, TTR, SCT
46glucose438.5TTR, REN, CCK, SLC17A5, SCT
47folate438.5CCK, SLC17A5, TTR, ABCC3
48retinoic acid43 249.4SCT, ABCC3, TTR, CCK
49atp43 289.2KHK, SCT, ABCC3, SLC17A5
50cholesterol43 28 24 1211.1CCK, ABCC3, TTR, REN, SLC17A5

GO Terms for genes affiliated with Obstructive Jaundice

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Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.6CCL25, CCK, REN, TTR
2extracellular regionGO:00055767.9CCL25, CCK, REN, TTR, SCT

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.6CCL25, CCK, TTR, SCT

Products for genes affiliated with Obstructive Jaundice

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Sources for Obstructive Jaundice

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet