MCID: OBS006
MIFTS: 51

Obstructive Lung Disease malady

Respiratory diseases category

Summaries for Obstructive Lung Disease

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Obstructive lung disease is a category of respiratory disease characterized by airway obstruction. It is... more...

MalaCards: Obstructive Lung Disease, also known as respiratory airway obstruction, is related to pneumonia and pulmonary disease, chronic obstructive. An important gene associated with Obstructive Lung Disease is AHSP (alpha hemoglobin stabilizing protein). The drugs oxygen and hydrocodone and the compounds nitroglycerin and captopril have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related mouse phenotypes are behavior/neurological and cardiovascular system.

Aliases & Classifications for Obstructive Lung Disease

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

obstructive lung disease 9
respiratory airway obstruction 9
lung diseases, obstructive 63
lung diseases obstructive 46


External Ids:

Disease Ontology9 DOID:2320
MeSH36 D008173

Related Diseases for Obstructive Lung Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Obstructive Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.4SFTPC
2pulmonary disease, chronic obstructive30.2AHSP, RNASE3
3congestive heart failure30.0AHSP, REN
4myocardial infarction30.0AGER, REN, AHSP
5atopy30.0LTA, RNASE3
6rheumatoid arthritis29.9RNASE3, AGER, LTA
7asthma10.7
8hypertension10.6
9cor pulmonale10.5
10respiratory failure10.4
11pulmonary function10.4
12bronchitis10.3
13cystic fibrosis10.3
14lung cancer10.2
15sleep apnea10.2
16bronchiolitis obliterans10.1
17obstructive sleep apnea10.1
18bronchiectasis10.1
19atherosclerosis10.1
20hepatitis10.1
21interstitial lung disease10.1
22lactic acidosis10.1
23obesity10.1
24osteoporosis10.1
25pneumothorax10.1
26pulmonary emphysema10.1
27thyroiditis10.1
28tuberculosis10.1
29congenital lobar emphysema10.1
30aneurysm10.1
31blindness10.1
32primary pulmonary hypertension10.0AHSP, SFTPC
33renovascular hypertension10.0AHSP, REN
34adult respiratory distress syndrome10.0LTA, SFTPC
35glomerulosclerosis10.0REN, AGER
36lung benign neoplasm10.0AGER, SFTPC
37periodontitis10.0AGER, LTA
38diabetic nephropathy10.0REN, AGER
39primary hyperoxaluria10.0AGER, REN
40vascular disease10.0AHSP, AGER
41lung adenocarcinoma10.0LTA, SFTPC
42essential hypertension10.0AGER, REN, AHSP
43pre-eclampsia10.0AHSP, REN, AGER
44angina pectoris10.0
45graft versus host disease10.0
46burns10.0
47hepatitis c10.0
48bronchiolitis10.0
49pulmonary tuberculosis10.0
50bronchiolitis obliterans organizing pneumonia10.0

Graphical network of the top 20 diseases related to Obstructive Lung Disease:



Diseases related to obstructive lung disease

Symptoms for Obstructive Lung Disease

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Drugs & Therapeutics for Obstructive Lung Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Obstructive Lung Disease

Drug clinical trials:

Search ClinicalTrials for Obstructive Lung Disease

Search NIH Clinical Center for Obstructive Lung Disease

Search CenterWatch for Obstructive Lung Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Obstructive Lung Disease

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Anatomical Context for Obstructive Lung Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Obstructive Lung Disease:

34
Lung, Testes, Heart, Bone, Bone marrow, Brain, Skeletal muscle, Thyroid, Colon, Endothelial

Animal Models for Obstructive Lung Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Obstructive Lung Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4LTA, AGER, REN, SFTPC
2MP:00053858.3SFTPC, REN, AGER, LTA
3MP:00053978.1AHSP, REN, AGER, LTA
4MP:00053877.9LTA, AGER, REN, AHSP, SFTPC

Publications for Obstructive Lung Disease

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Sources:
53PubMed
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Articles related to Obstructive Lung Disease:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. (23494492)
2013
2
Chronic obstructive pulmonary disease prevalence in lisbon, portugal: the burden of obstructive lung disease study. (23664024)
2013
3
Vitamin D serum level and chronic obstructive lung disease. (24009949)
2013
4
Hepatitis C Virus Infection Is Not An Independent Risk Factor For Obstructive Lung Disease. (23862666)
2013
5
Increased prevalence of obstructive lung disease in patients with obstructive sleep apnea. (23733255)
2013
6
Classification of Chronic Obstructive Pulmonary Disease Severity According to the New Global Initiative for Chronic Obstructive Lung Disease 2011 Guidelines: COPD Assessment Test Versus Modified Medical Research Council Scale. (24268434)
2013
7
Perseverant, non-indicated treatment of obese patients for obstructive lung disease. (24266961)
2013
8
Ventilator-associated problems related to obstructive lung disease. (23709193)
2013
9
Spirometry in chronic obstructive lung disease (COPD). (23155809)
2012
10
Association between I^-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. (22941975)
2012
11
CFTR regulates early pathogenesis of chronic obstructive lung disease in I^ENaC-overexpressing mice. (22937152)
2012
12
Significance of the microbiome in obstructive lung disease. (22318161)
2012
13
Complete spontaneous regression of a total pneumothorax in a patient with chronic obstructive lung disease. (22514577)
2011
14
COPD in never smokers: results from the population-based burden of obstructive lung disease study. (20884729)
2011
15
Medication changes prior to hospitalization for obstructive lung disease: a case-crossover study. (20071496)
2010
16
Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report. (19368725)
2009
17
Development of an automatic classification system for differentiation of obstructive lung disease using HRCT. (18712567)
2009
18
Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study. (18682520)
2008
19
Obstructive lung disease models: what is valid? (19353353)
2008
20
From Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines to current clinical practice : an overview of the pharmacological therapy of stable chronic obstructive pulmonary disorder. (16823994)
2006
21
Global initiative for chronic obstructive lung disease for chronic obstructive pulmonary disease: GOLD opportunity for lung disorders. (15533539)
2005
22
Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. (16060696)
2005
23
Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. (15920100)
2005
24
Seattle Obstructive Lung Disease Questionnaire: sensitivity to outcomes in pulmonary rehabilitation in severe pulmonary illness. (15818200)
2005
25
Allelic variants of the tumor necrosis factor superfamily as markers of the severity of the course of chronic obstructive lung disease and bronchiectatic disease]. (15174288)
2004
26
Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden Studies. (12587960)
2003
27
Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. (14564356)
2003
28
Seretide for obstructive lung disease. (11866683)
2002
29
"Natural history" of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease. (11463591)
2001
30
Co-prescribing of medications used to treat obstructive lung disease, congestive heart failure and depression among users of topical beta blockers: estimates from three US Veterans Affairs Medical Centers. (11828833)
2001
31
Ischemic hepatitis induced by mesenteric volvulus in a patient with chronic obstructive lung disease. (10680675)
2000
32
Different pattern of risk factors for atopic and nonatopic asthma among children--report from the Obstructive Lung Disease in Northern Sweden Study. (10505455)
1999
33
Exercise limitation in obstructive lung disease. (9792562)
1998
34
Mechanical ventilation in obstructive lung disease. (8875012)
1996
35
Medium term functional results of single-lung transplantation for endstage obstructive lung disease. (8049821)
1994
36
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life. (1609376)
1992
37
Induction of sleep apnoea with negative pressure ventilation in patients with chronic obstructive lung disease. (1412118)
1992
38
IgG subclass deficiency associated with corticosteroids in obstructive lung disease. (1343817)
1992
39
Nutritional support in chronic obstructive lung disease. (1519188)
1992
40
Breathing during sleep in patients with obstructive lung disease. (2183654)
1990
41
Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. (2122253)
1990
42
The influence of nifedipine (Corinfar) on pulmonary hypertension in chronic obstructive lung disease. (2127872)
1990
43
Comparison of almitrine bismesylate and medroxyprogesterone acetate on oxygenation during wakefulness and sleep in patients with chronic obstructive lung disease. (2145654)
1990
44
Fibrinolysis, immune reactivity and the structure of the blood serum albumin in obstructive lung diseases combined with atherosclerosis]. (2077278)
1990
45
Evaluation of the safety and efficacy of amrinone in chronic obstructive lung disease with cor pulmonale. (2316304)
1990
46
Sauna to transiently improve pulmonary function in patients with obstructive lung disease. (2596966)
1989
47
Long-term treatment of chronic obstructive lung disease by Nifedipine: an 18-month haemodynamic study. (3069486)
1988
48
Pathophysiological aspects of predominant preload lowering on pulmonary circulation, gas exchange, and the biventricular function in patients with chronic obstructive lung disease. (3229018)
1988
49
Comparison of arm and leg ergometry in patients with moderate chronic obstructive lung disease. (3222762)
1988
50
Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease. (3824271)
1986

Variations for Obstructive Lung Disease

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Expression for genes affiliated with Obstructive Lung Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obstructive Lung Disease

Search GEO for disease gene expression data for Obstructive Lung Disease.

Pathways for genes affiliated with Obstructive Lung Disease

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Compounds for genes affiliated with Obstructive Lung Disease

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Obstructive Lung Disease according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1nitroglycerin46 1210.9REN, AHSP
2captopril46 62 52 30 1213.9AHSP, REN
3clonidine46 52 30 1212.9REN, AHSP
4olmesartan46 30 1211.9AGER, REN
5telmisartan46 30 1211.8AGER, REN
6sodium nitroprusside469.8REN, AHSP
7candesartan46 52 30 1212.8REN, AGER
8verapamil46 30 52 25 1213.8AHSP, REN
9cgmp46 3010.7REN, AHSP
10nifedipine46 30 52 1212.7AGER, REN
11isoproterenol46 1210.5REN, AHSP
12thyroxine46 2510.5REN, LTA
13txb2469.5RNASE3, REN
14uric acid46 2510.5AGER, RNASE3
15prostacyclin469.4AHSP, REN, AGER
16ibmx46 62 3011.4RNASE3, SFTPC
17enterotoxin469.4LTA, RNASE3
18p005469.4LTA, RNASE3
19dopamine46 30 25 1212.4AGER, REN, AHSP
20calcitriol46 62 25 1212.3LTA, REN
21indomethacin46 30 62 1212.3AHSP, REN, LTA
22p003469.3LTA, RNASE3
23cyclic amp46 2510.3SFTPC, AHSP, LTA
24prednisolone46 30 1211.3LTA, RNASE3
25prostaglandin469.2REN, AHSP
26fibrinogen469.2RNASE3, AHSP, SFTPC
27hyaluronic acid46 2510.2LTA, RNASE3
28methacholine46 52 1211.2REN, RNASE3, AHSP
29sodium46 2510.1REN, RNASE3, AHSP
30heparin46 30 25 1212.1AGER, RNASE3, AHSP
31endotoxin469.0LTA, RNASE3, AHSP
32acetylcholine46 52 30 25 1213.0LTA, RNASE3, AHSP
33creatinine469.0RNASE3, REN, AGER
34fmlp468.9LTA, RNASE3
35oxygen46 259.9SFTPC, AHSP, AGER, LTA
36steroid468.8LTA, REN, RNASE3
37oligonucleotide468.8RNASE3, AGER, LTA
38glucose468.8LTA, AGER, REN, AHSP
39estrogen468.7LTA, RNASE3, AHSP
40arginine468.7REN, RNASE3, AHSP, SFTPC
41retinoic acid46 259.6SFTPC, RNASE3, LTA
42pge2468.5LTA, REN, RNASE3, AHSP
43dexamethasone46 52 30 1211.5SFTPC, RNASE3, REN, LTA
44cholesterol46 30 25 1211.4LTA, AGER, REN, AHSP, SFTPC
45lipid468.1SFTPC, AHSP, RNASE3, AGER, LTA
46nitric oxide46 25 1210.0AHSP, RNASE3, REN, AGER, LTA
47vegf468.0SFTPC, RNASE3, REN, AGER, LTA
48calcium46 52 25 1210.6SFTPC, AHSP, RNASE3, REN, AGER, LTA

GO Terms for genes affiliated with Obstructive Lung Disease

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Sources:
17Gene Ontology
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Cellular components related to Obstructive Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9LTA, REN, SFTPC

Biological processes related to Obstructive Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cAMPGO:0515919.5REN, SFTPC
2response to lipopolysaccharideGO:0324968.6LTA, REN, SFTPC

Products for genes affiliated with Obstructive Lung Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Obstructive Lung Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet