MCID: OBS006
MIFTS: 53

Obstructive Lung Disease malady

Respiratory diseases category
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Summaries for Obstructive Lung Disease

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Wikipedia:65 Obstructive lung disease is a category of respiratory disease characterized by airway obstruction. It is... more...

MalaCards based summary: Obstructive Lung Disease, also known as respiratory airway obstruction, is related to pulmonary hypertension and chronic obstructive pulmonary disease. An important gene associated with Obstructive Lung Disease is AHSP (alpha hemoglobin stabilizing protein). The drugs hydrocodone and oxygen and the compounds nitroglycerin and captopril have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related mouse phenotypes are behavior/neurological and cardiovascular system.

Aliases & Classifications for Obstructive Lung Disease

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH
See all sources

Obstructive Lung Disease, Aliases & Descriptions:

Name: Obstructive Lung Disease 8
Respiratory Airway Obstruction 8 62
 
Lung Diseases, Obstructive 62
Lung Diseases Obstructive 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:2320
MeSH34 D008173

Related Diseases for Obstructive Lung Disease

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Diseases related to Obstructive Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension31.3AHSP, SFTPC
2chronic obstructive pulmonary disease30.9AHSP, RNASE3
3pneumonia30.8SFTPC
4congestive heart failure30.3AHSP, REN
5myocardial infarction30.0AGER, REN, AHSP
6atopy29.9LTA, RNASE3
7rheumatoid arthritis29.6RNASE3, AGER, LTA
8asthma10.7
9hypertension10.7
10cor pulmonale10.5
11respiratory failure10.5
12pulmonary function10.5
13bronchitis10.4
14cystic fibrosis10.3
15lung cancer10.2
16sleep apnea10.2
17blindness10.2
18renovascular hypertension10.2AHSP, REN
19atherosclerosis10.2
20bronchiolitis obliterans10.2
21hepatitis10.2
22ischemic heart disease10.2
23obesity10.2
24osteoporosis10.2
25pulmonary emphysema10.2
26obstructive sleep apnea10.2
27bronchiectasis10.2
28interstitial lung disease10.2
29lactic acidosis10.2
30pneumothorax10.2
31thyroiditis10.2
32tuberculosis10.2
33congenital lobar emphysema10.2
34aneurysm10.2
35adult respiratory distress syndrome10.1LTA, SFTPC
36glomerulosclerosis10.1REN, AGER
37lung benign neoplasm10.1AGER, SFTPC
38periodontitis10.1AGER, LTA
39diabetic nephropathy10.1REN, AGER
40primary hyperoxaluria10.0AGER, REN
41vascular disease10.0AHSP, AGER
42angina pectoris10.0
43acute myocardial infarction10.0
44alpha 1-antitrypsin deficiency10.0
45arthritis10.0
46bronchopulmonary dysplasia10.0
47burns10.0
48diabetes mellitus10.0
49graft versus host disease10.0
50idiopathic pulmonary fibrosis10.0

Graphical network of the top 20 diseases related to Obstructive Lung Disease:



Diseases related to obstructive lung disease

Symptoms for Obstructive Lung Disease

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Drugs & Therapeutics for Obstructive Lung Disease

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Drug clinical trials:

Search ClinicalTrials for Obstructive Lung Disease

Search NIH Clinical Center for Obstructive Lung Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Obstructive Lung Disease

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Anatomical Context for Obstructive Lung Disease

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MalaCards organs/tissues related to Obstructive Lung Disease:

32
Lung, Heart, Testes, Bone, Bone marrow, Brain, Skeletal muscle, Thyroid, Neutrophil, Colon, Liver, Endothelial

Animal Models for Obstructive Lung Disease or affiliated genes

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MGI Mouse Phenotypes related to Obstructive Lung Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4LTA, AGER, REN, SFTPC
2MP:00053858.3SFTPC, REN, AGER, LTA
3MP:00053978.1AHSP, REN, AGER, LTA
4MP:00053877.9LTA, AGER, REN, AHSP, SFTPC

Publications for Obstructive Lung Disease

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Articles related to Obstructive Lung Disease:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD. (25142487)
2014
2
Adherence to the Global Initiative for Chronic Obstructive Lung Disease guidelines for management of COPD: a hospital-base study. (25308344)
2014
3
Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. (23494492)
2013
4
Chronic obstructive pulmonary disease prevalence in lisbon, portugal: the burden of obstructive lung disease study. (23664024)
2013
5
Vitamin D serum level and chronic obstructive lung disease. (24009949)
2013
6
Hepatitis C Virus Infection Is Not An Independent Risk Factor For Obstructive Lung Disease. (23862666)
2013
7
Increased prevalence of obstructive lung disease in patients with obstructive sleep apnea. (23733255)
2013
8
Classification of Chronic Obstructive Pulmonary Disease Severity According to the New Global Initiative for Chronic Obstructive Lung Disease 2011 Guidelines: COPD Assessment Test Versus Modified Medical Research Council Scale. (24268434)
2013
9
Perseverant, non-indicated treatment of obese patients for obstructive lung disease. (24266961)
2013
10
Spirometry in chronic obstructive lung disease (COPD). (23155809)
2012
11
Association between I^-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. (22941975)
2012
12
CFTR regulates early pathogenesis of chronic obstructive lung disease in I^ENaC-overexpressing mice. (22937152)
2012
13
Significance of the microbiome in obstructive lung disease. (22318161)
2012
14
Complete spontaneous regression of a total pneumothorax in a patient with chronic obstructive lung disease. (22514577)
2011
15
Medication changes prior to hospitalization for obstructive lung disease: a case-crossover study. (20071496)
2010
16
Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report. (19368725)
2009
17
Development of an automatic classification system for differentiation of obstructive lung disease using HRCT. (18712567)
2009
18
Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study. (18682520)
2008
19
Obstructive lung disease models: what is valid? (19353353)
2008
20
From Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines to current clinical practice : an overview of the pharmacological therapy of stable chronic obstructive pulmonary disorder. (16823994)
2006
21
Global initiative for chronic obstructive lung disease for chronic obstructive pulmonary disease: GOLD opportunity for lung disorders. (15533539)
2005
22
Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. (16060696)
2005
23
Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. (15920100)
2005
24
Seattle Obstructive Lung Disease Questionnaire: sensitivity to outcomes in pulmonary rehabilitation in severe pulmonary illness. (15818200)
2005
25
Allelic variants of the tumor necrosis factor superfamily as markers of the severity of the course of chronic obstructive lung disease and bronchiectatic disease]. (15174288)
2004
26
Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden Studies. (12587960)
2003
27
Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. (14564356)
2003
28
Seretide for obstructive lung disease. (11866683)
2002
29
"Natural history" of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease. (11463591)
2001
30
Co-prescribing of medications used to treat obstructive lung disease, congestive heart failure and depression among users of topical beta blockers: estimates from three US Veterans Affairs Medical Centers. (11828833)
2001
31
Ischemic hepatitis induced by mesenteric volvulus in a patient with chronic obstructive lung disease. (10680675)
2000
32
Different pattern of risk factors for atopic and nonatopic asthma among children--report from the Obstructive Lung Disease in Northern Sweden Study. (10505455)
1999
33
Exercise limitation in obstructive lung disease. (9792562)
1998
34
Mechanical ventilation in obstructive lung disease. (8875012)
1996
35
Medium term functional results of single-lung transplantation for endstage obstructive lung disease. (8049821)
1994
36
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life. (1609376)
1992
37
Induction of sleep apnoea with negative pressure ventilation in patients with chronic obstructive lung disease. (1412118)
1992
38
IgG subclass deficiency associated with corticosteroids in obstructive lung disease. (1343817)
1992
39
Nutritional support in chronic obstructive lung disease. (1519188)
1992
40
Breathing during sleep in patients with obstructive lung disease. (2183654)
1990
41
Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. (2122253)
1990
42
The influence of nifedipine (Corinfar) on pulmonary hypertension in chronic obstructive lung disease. (2127872)
1990
43
Comparison of almitrine bismesylate and medroxyprogesterone acetate on oxygenation during wakefulness and sleep in patients with chronic obstructive lung disease. (2145654)
1990
44
Fibrinolysis, immune reactivity and the structure of the blood serum albumin in obstructive lung diseases combined with atherosclerosis]. (2077278)
1990
45
Evaluation of the safety and efficacy of amrinone in chronic obstructive lung disease with cor pulmonale. (2316304)
1990
46
Sauna to transiently improve pulmonary function in patients with obstructive lung disease. (2596966)
1989
47
Long-term treatment of chronic obstructive lung disease by Nifedipine: an 18-month haemodynamic study. (3069486)
1988
48
Pathophysiological aspects of predominant preload lowering on pulmonary circulation, gas exchange, and the biventricular function in patients with chronic obstructive lung disease. (3229018)
1988
49
Comparison of arm and leg ergometry in patients with moderate chronic obstructive lung disease. (3222762)
1988
50
Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease. (3824271)
1986

Variations for Obstructive Lung Disease

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Expression for genes affiliated with Obstructive Lung Disease

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Expression patterns in normal tissues for genes affiliated with Obstructive Lung Disease

Search GEO for disease gene expression data for Obstructive Lung Disease.

Pathways for genes affiliated with Obstructive Lung Disease

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Compounds for genes affiliated with Obstructive Lung Disease

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Compounds related to Obstructive Lung Disease according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1nitroglycerin44 1110.9REN, AHSP
2captopril44 61 50 28 1113.9AHSP, REN
3clonidine44 50 28 1112.9REN, AHSP
4olmesartan44 28 1111.9AGER, REN
5telmisartan44 28 1111.8AGER, REN
6sodium nitroprusside449.8REN, AHSP
7candesartan44 50 28 1112.8REN, AGER
8verapamil44 28 50 24 1113.8AHSP, REN
9cgmp44 2810.7REN, AHSP
10nifedipine44 28 50 1112.7AGER, REN
11isoproterenol44 1110.5REN, AHSP
12thyroxine44 2410.5REN, LTA
13txb2449.5RNASE3, REN
14uric acid44 2410.5AGER, RNASE3
15prostacyclin449.4AHSP, REN, AGER
16ibmx44 61 2811.4RNASE3, SFTPC
17enterotoxin449.4LTA, RNASE3
18p005449.4LTA, RNASE3
19dopamine44 28 24 1112.4AGER, REN, AHSP
20calcitriol44 61 24 1112.3LTA, REN
21indomethacin44 28 61 1112.3AHSP, REN, LTA
22p003449.3LTA, RNASE3
23cyclic amp44 2410.3SFTPC, AHSP, LTA
24prednisolone44 28 1111.3LTA, RNASE3
25prostaglandin449.2REN, AHSP
26fibrinogen449.2RNASE3, AHSP, SFTPC
27hyaluronic acid44 2410.2LTA, RNASE3
28methacholine44 50 1111.2REN, RNASE3, AHSP
29sodium44 2410.1REN, RNASE3, AHSP
30heparin44 28 24 1112.1AGER, RNASE3, AHSP
31endotoxin449.0LTA, RNASE3, AHSP
32acetylcholine44 50 28 24 1113.0LTA, RNASE3, AHSP
33creatinine449.0RNASE3, REN, AGER
34fmlp448.9LTA, RNASE3
35oxygen44 249.9SFTPC, AHSP, AGER, LTA
36steroid448.8LTA, REN, RNASE3
37oligonucleotide448.8RNASE3, AGER, LTA
38glucose448.8LTA, AGER, REN, AHSP
39estrogen448.7LTA, RNASE3, AHSP
40arginine448.7REN, RNASE3, AHSP, SFTPC
41retinoic acid44 249.6SFTPC, RNASE3, LTA
42pge2448.5LTA, REN, RNASE3, AHSP
43dexamethasone44 50 28 1111.5SFTPC, RNASE3, REN, LTA
44cholesterol44 28 24 1111.4LTA, AGER, REN, AHSP, SFTPC
45lipid448.1SFTPC, AHSP, RNASE3, AGER, LTA
46nitric oxide44 24 1110.0AHSP, RNASE3, REN, AGER, LTA
47vegf448.0SFTPC, RNASE3, REN, AGER, LTA
48calcium44 50 24 1110.6SFTPC, AHSP, RNASE3, REN, AGER, LTA

GO Terms for genes affiliated with Obstructive Lung Disease

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Cellular components related to Obstructive Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9LTA, REN, SFTPC

Biological processes related to Obstructive Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cAMPGO:0515919.5REN, SFTPC
2response to lipopolysaccharideGO:0324968.6LTA, REN, SFTPC

Products for genes affiliated with Obstructive Lung Disease

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Sources for Obstructive Lung Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet