MCID: OBS061
MIFTS: 65

Obstructive Sleep Apnea

Categories: Neuronal diseases, Mental diseases

Aliases & Classifications for Obstructive Sleep Apnea

MalaCards integrated aliases for Obstructive Sleep Apnea:

Name: Obstructive Sleep Apnea 12 29 14
Sleep Apnea Syndromes 42 69
Obstructive Sleep Apnea Syndrome 12
Sleep Apnea, Obstructive 69
Sleep Apnea Obstructive 52

Classifications:



Summaries for Obstructive Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.

MalaCards based summary : Obstructive Sleep Apnea, also known as sleep apnea syndromes, is related to ischemic heart disease and angina pectoris, and has symptoms including back pain, cheyne-stokes respiration and coughing. An important gene associated with Obstructive Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Nebivolol and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or... more...

Related Diseases for Obstructive Sleep Apnea

Diseases related to Obstructive Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
id Related Disease Score Top Affiliating Genes
1 ischemic heart disease 30.2 ACE CRP HTR2A IL6 SELP
2 angina pectoris 30.0 ACE CRP IL6 SELP
3 dysphagia 29.9 CXCL8 ICAM1 IL6 TNF
4 pulmonary embolism 29.8 CRP CXCL8 IL6 TNF
5 choroiditis 29.3 ACE CRP CXCL8 IL6 TNF
6 asthma 28.1 CHI3L1 CXCL8 EDN1 ICAM1 IL6 LEP
7 myocardial infarction 26.7 ACE ADIPOQ APOE CRP EDN1 ICAM1
8 autoimmune encephalopathy with parasomnia and obstructive sleep apnea 12.2
9 sleep apnea 11.8
10 polycystic ovary syndrome 11.3
11 xia-gibbs syndrome 11.2
12 smarca4-deficient sarcoma of thorax 11.0 IL6 TNF
13 autoimmune hemolytic anemia, warm type 10.9 ACE APOE
14 alzheimer's disease 10 10.9 APOE HTR2A
15 collagenopathy type 2 alpha 1 10.9 CRP IL6
16 potato nose 10.9 ACE IL6 TNF
17 epstein-barr virus hepatitis 10.8 CRP IL6 TNF
18 central nervous system leiomyosarcoma 10.8 CRP IL6 TNF
19 acquired hypoprothrombinemia 10.8 ADIPOQ LEP
20 ostertagiasis 10.8 ACE IL6 TNF
21 benign neonatal seizures 10.8 CRP IL6 TNF
22 chronic fungal otitis externa 10.8 CRP INS
23 chronic diarrhea due to guanylate cyclase 2c overactivity 10.8 ACE CRP IL6
24 not otherwise specified 3-mga-uria type 10.8 ADIPOQ LEP TNF
25 early congenital syphilis 10.8 CRP IL6 TNF
26 plummer's disease 10.8 CRP IL6 TNF
27 residual stage corticosteroid-induced glaucoma 10.8 CRP IL6 TNF
28 high pressure neurological syndrome 10.8 EDN1 IL6 TNF
29 c1 inhibitor deficiency 10.8 CRP IL6 TNF
30 pancreas lymphoma 10.8 CRP IL6 TNF
31 cornea cancer 10.8 CRP IL6 TNF
32 rift valley fever 10.8 CRP IL6 TNF
33 spindle cell hemangioma 10.8 ICAM1 LEP TNF
34 hematocele of tunica vaginalis testis 10.8 ADIPOQ EDN1 TNF
35 conduct disorder 10.8 ICAM1 IL6 TNF
36 hypothyroidism due to iodide transport defect 10.8 ACE REN
37 dermatomycosis 10.7 CRP ICAM1 TNF
38 opportunistic bacterial infectious disease 10.7 CRP IL6 TNF
39 pauci-immune glomerulonephritis with anca 10.7 HTR2A INS TNF
40 emphysema, congenital lobar 10.7 CRP IL6 TNF
41 uterine inflammatory disease 10.7 EDN1 REN
42 lymphoma 10.7 ACE IL6 TNF
43 acute interstitial pneumonia 10.7 ICAM1 IL6 TNF
44 hypomagnesemia 3, renal 10.7 ADIPOQ INS LEP
45 cataract, autosomal dominant congenital 4 10.7 ACE APOE INS
46 renal tubular acidosis 10.7 ACE ICAM1 TNF
47 signet ring cell adenocarcinoma 10.7 CHI3L1 CRP TNF
48 glossopharyngeal nerve disease 10.7 ACE APOE CRP
49 bacterial gastritis 10.7 CRP IL6 TNF
50 isthmus cancer 10.7 CRP IL6 TNF

Graphical network of the top 20 diseases related to Obstructive Sleep Apnea:



Diseases related to Obstructive Sleep Apnea

Symptoms & Phenotypes for Obstructive Sleep Apnea

UMLS symptoms related to Obstructive Sleep Apnea:


back pain, cheyne-stokes respiration, coughing, dyspnea, headache, pain, sciatica, seizures, sleep disturbances, snoring, syncope, tremor, wheezing, chronic pain, vertigo/dizziness, labored breathing, excessive daytime somnolence, sleeplessness, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Obstructive Sleep Apnea:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACE ADIPOQ APOE CRP EDN1 HCRT
2 homeostasis/metabolism MP:0005376 10.43 ACE ADIPOQ APOE CRP EDN1 HCRT
3 growth/size/body region MP:0005378 10.42 ACE ADIPOQ REN SELP TNF APOE
4 behavior/neurological MP:0005386 10.4 ACE SELP TNF ADIPOQ APOE HCRT
5 immune system MP:0005387 10.39 CHI3L1 CRP ICAM1 IGF1 IL6 INS
6 hematopoietic system MP:0005397 10.38 ADIPOQ APOE CHI3L1 ICAM1 IGF1 IL6
7 endocrine/exocrine gland MP:0005379 10.37 HTR2A ICAM1 IGF1 IL6 INS LEP
8 cellular MP:0005384 10.35 ADIPOQ APOE CHI3L1 ICAM1 IGF1 IL6
9 adipose tissue MP:0005375 10.3 ADIPOQ APOE IGF1 IL6 INS LEP
10 mortality/aging MP:0010768 10.3 TNF ACE ADIPOQ APOE EDN1 ICAM1
11 muscle MP:0005369 10.28 ADIPOQ APOE EDN1 HCRT HTR2A ICAM1
12 digestive/alimentary MP:0005381 10.27 APOE EDN1 HTR2A ICAM1 IL6 INS
13 integument MP:0010771 10.19 ADIPOQ APOE ICAM1 IGF1 IL6 INS
14 liver/biliary system MP:0005370 10.18 ACE ADIPOQ APOE IL6 INS LEP
15 nervous system MP:0003631 10.18 APOE EDN1 HCRT ICAM1 IGF1 IL6
16 renal/urinary system MP:0005367 10.1 ACE ADIPOQ APOE EDN1 IGF1 IL6
17 neoplasm MP:0002006 10.01 IGF1 IL6 LEP LEPR TNF ACE
18 reproductive system MP:0005389 9.96 ACE APOE IGF1 IL6 INS LEP
19 respiratory system MP:0005388 9.85 IGF1 IL6 LEP LEPR NOS3 SELP
20 skeleton MP:0005390 9.73 ADIPOQ APOE EDN1 HTR2A IGF1 IL6
21 vision/eye MP:0005391 9.28 APOE ICAM1 IL6 INS LEP LEPR

Drugs & Therapeutics for Obstructive Sleep Apnea

Drugs for Obstructive Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 406)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
2
Donepezil Approved Phase 4 120014-06-4 3152
3
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 63006 5281004
4
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
6
Nitric Oxide Approved Phase 4 10102-43-9 145068
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
8
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
9
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1 57-27-2 5288826
10
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
11
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
12
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
13
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
14
Sodium oxybate Approved Phase 4 502-85-2 5360545
15
Zolpidem Approved Phase 4 82626-48-0 5732
16
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
17
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
18
Acetazolamide Approved, Vet_approved Phase 4,Phase 2 59-66-5 1986
19
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
20
Adalimumab Approved Phase 4 331731-18-1 16219006
21
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
22
Ephedrine Approved Phase 4 299-42-3 9294
23
Pseudoephedrine Approved Phase 4 90-82-4 7028
24
Xylometazoline Approved Phase 4 526-36-3 5709
25
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
26
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
27
Norepinephrine Approved Phase 4 51-41-2 439260
28
Eplerenone Approved Phase 4 107724-20-9 150310 443872
29
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
30
Eszopiclone Approved Phase 4,Phase 2,Early Phase 1 138729-47-2 969472
31
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
32
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
33
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
34
Pantoprazole Approved Phase 4 102625-70-7 4679
35
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
36
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
37
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
38
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
39
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
40
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 75614-87-8, 51-45-6 774
41
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
42
Oxymetazoline Approved Phase 4,Phase 3,Phase 2 1491-59-4 4636
43
Phenylephrine Approved Phase 4,Phase 3,Phase 2 59-42-7 6041
44
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
45
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
46
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
47
Testosterone Approved, Investigational Phase 4 58-22-0 6013
48
Carbidopa Approved Phase 4 28860-95-9 34359 38101
49
Levodopa Approved Phase 4 59-92-7 6047
50
Desflurane Approved Phase 4 57041-67-5 42113

Interventional clinical trials:

(show top 50) (show all 1299)

id Name Status NCT ID Phase Drugs
1 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
2 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
3 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
4 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
5 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
6 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Unknown status NCT01699126 Phase 4 Statin
7 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
8 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
9 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
10 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
11 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
12 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
13 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
14 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
15 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
16 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
17 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4 Sugammadex;Neostigmine
18 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
19 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
20 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
21 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
22 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4 Donepezil;placebo
23 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
24 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
25 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4 armodafinil;placebo
26 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
27 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
28 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
29 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4 Sibutramine
30 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
31 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4 xylometazoline
32 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls. Completed NCT00291993 Phase 4
33 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
34 Effects of Continuous Positive Airway Pressure and Valsartan Treatments on Arterial Blood Pressure in OSAS Patients Completed NCT00409487 Phase 4 Valsartant treatment
35 Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2) Completed NCT00633711 Phase 4
36 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
37 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)
38 Obstructive Sleep Apnea (OSA), Sleepiness, and Activity in Diabetes Management Completed NCT00801892 Phase 4
39 Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
40 Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP) Completed NCT00612157 Phase 4 Eszopiclone;Placebo control
41 Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study Completed NCT02293746 Phase 4
42 Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea Completed NCT01945801 Phase 4 Lasilactone;Placebo
43 Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea Completed NCT00772044 Phase 4
44 A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial Completed NCT01895348 Phase 4 Propofol;propofol-remifentanil;Dexmedetomidine-remifentanil
45 Auto Bilevel Adherence Following a Poor Initial Encounter With Continuous Positive Airway Pressure (CPAP) Completed NCT02522442 Phase 4
46 Ezopiclone Improves the Quality of Overnight Polysomnography Completed NCT00507117 Phase 4 Lunesta;Placebo control
47 Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment Completed NCT00701428 Phase 4 Losartan
48 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
49 Pre and Post Orthopedic Surgery Sleep and Cardiac Testing (PROSPECT) Completed NCT00785070 Phase 4
50 Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance Completed NCT00711516 Phase 4 Armodafinil;Placebo

Search NIH Clinical Center for Obstructive Sleep Apnea

Cochrane evidence based reviews: sleep apnea syndromes

Genetic Tests for Obstructive Sleep Apnea

Genetic tests related to Obstructive Sleep Apnea:

id Genetic test Affiliating Genes
1 Obstructive Sleep Apnea 29

Anatomical Context for Obstructive Sleep Apnea

MalaCards organs/tissues related to Obstructive Sleep Apnea:

39
Heart, Endothelial, Testes, Liver, Tongue, Kidney, Brain

Publications for Obstructive Sleep Apnea

Articles related to Obstructive Sleep Apnea:

(show top 50) (show all 1114)
id Title Authors Year
1
Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome. ( 27754829 )
2017
2
Risk of obstructive sleep apnea among patients with Cushing's syndrome: a nationwide longitudinal study. ( 28735920 )
2017
3
The importance of calprotectin levels in the obstructive sleep apnea syndrome severity. ( 28933970 )
2017
4
Obstructive sleep apnea risk and leukocyte telomere length in African Americans from the MH-GRID study. ( 28083855 )
2017
5
Corrigendum to "Screening, diagnosis, and management of obstructive sleep apnea in dangerous-goods truck drivers: to be aware or not?" [Sleep Med. 2016;25:98-104]. ( 28057498 )
2017
6
Increased prevalence of obstructive sleep apnea in patients with Cushing's syndrome compared with weight- and age-matched controls. ( 27932409 )
2017
7
The Erlangen Questionnaire: a new 5-item screening tool for obstructive sleep apnea in a sleep clinic population - A prospective, double blinded study. ( 28925472 )
2017
8
Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea. ( 27321703 )
2017
9
Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. ( 28449901 )
2017
10
Corrigendum to "Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome" [Sleep Med 27-28 (2016) 99-106]. ( 28457800 )
2017
11
Determinants of obstructive sleep apnea syndrome: Pro-inflammatory state and dysfunction of high-density lipoprotein. ( 28935145 )
2017
12
Tracking Dynamic Tongue Motion in Ultrasound Images for Obstructive Sleep Apnea. ( 28942270 )
2017
13
A comparison of two screening tools for paediatric obstructive sleep apnea. ( 28944605 )
2017
14
Obstructive Sleep Apnea and Pulmonary Hypertension in Children. ( 28185814 )
2017
15
Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea. ( 28920756 )
2017
16
Is C-reactive protein a marker of obstructive sleep apnea?: A meta-analysis. ( 28489776 )
2017
17
The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome. ( 28479031 )
2017
18
RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA AND THE PRESENCE AND SEVERITY OF DIABETIC RETINOPATHY. ( 28937527 )
2017
19
Diastolic Blood Pressure Rises with the Exacerbation of Obstructive Sleep Apnea in Males. ( 28922573 )
2017
20
Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia. ( 28366339 )
2017
21
Effect of jaw-opening exercise on prevention of temporomandibular disorders pain associated with oral appliance therapy in obstructive sleep apnea patients: A randomized, double-blind, placebo-controlled trial. ( 28063976 )
2017
22
Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds. ( 28931931 )
2017
23
Epidemiological characteristics and gender-specific differences of obstructive sleep apnea in a Chinese hypertensive population: a cross-sectional study. ( 28056799 )
2017
24
The association of nonalcoholic steatohepatitis and obstructive sleep apnea. ( 28914694 )
2017
25
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
26
C-reactive protein improves the ability to detect cardiometabolic risk in mild-to-moderate obstructive sleep apnea. ( 28947597 )
2017
27
REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? ( 28754242 )
2017
28
Carotid Artery Wall Thickness in Obese and Nonobese Adults With Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatment. ( 28934533 )
2017
29
Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population: A population-based study. ( 28422847 )
2017
30
Evaluation of Cerebrovascular Reactivity in Subjects with and without Obstructive Sleep Apnea. ( 28918088 )
2017
31
Surgical Treatment of Obstructive Sleep Apnea on Cardiovascular Outcomes: A Systematic Review. ( 28923761 )
2017
32
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
33
Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A case series. ( 28545360 )
2017
34
Maxillary Expansion and Mandibular Setback Surgery With and Without Mandibular Anterior Segment Osteotomy to Correct Mandibular Prognathism With Obstructive Sleep Apnea. ( 28060088 )
2017
35
Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes. ( 28931780 )
2017
36
Gray Matter Hypertrophy and Thickening with Obstructive Sleep Apnea in Middle-aged and Older Adults. ( 28060546 )
2017
37
The Role of Dentists in the Diagnosis and Treatment of Obstructive Sleep Apnea: Consensus and Controversy. ( 28942761 )
2017
38
New Uses for Old Biomarkers in chronic obstructive pulmonar disease and Obstructive Sleep Apnea? ( 28089428 )
2017
39
Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene. ( 28514291 )
2017
40
Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis. ( 28934188 )
2017
41
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea. ( 28078488 )
2017
42
The Presence of Conjunctivochalasis in Obstructive Sleep Apnea Patients. ( 28099284 )
2017
43
Adenotonsillectomy outcomes in patients with Down syndrome and obstructive sleep apnea. ( 28055122 )
2017
44
Ocular Manifestations of Obstructive Sleep Apnea. ( 28942764 )
2017
45
Single Nucleotide Polymorphisms in Adiponectin Gene Are Not Directly Associated with Increased Risk of Obstructive Sleep Apnea Syndrome in a Chinese Han Population. ( 28068661 )
2017
46
Urinary biomarkers and obstructive sleep apnea in patients with Down syndrome. ( 28522103 )
2017
47
Vascular endothelial growth factor levels in patients with obstructive sleep apnea: a meta-analysis. ( 27236786 )
2017
48
Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy. ( 28081532 )
2017
49
Investigation of the link between fluid shift and airway collapsibility as a mechanism for obstructive sleep apnea in congestive heart failure. ( 28057850 )
2017
50
Combined Orthodontic and Surgical Treatment in a 8-Years-Old Patient Affected By Severe Obstructive Sleep Apnea: A Case-Report. ( 28937905 )
2017

Variations for Obstructive Sleep Apnea

ClinVar genetic disease variations for Obstructive Sleep Apnea:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 AHDC1 NM_001029882.3(AHDC1): c.2373_2374delTG (p.Cys791Trpfs) deletion Pathogenic rs587779766 GRCh37 Chromosome 1, 27876253: 27876254
2 AHDC1 NM_001029882.3(AHDC1): c.2898delC (p.Tyr967Thrfs) deletion Pathogenic rs587779767 GRCh37 Chromosome 1, 27875729: 27875729
3 AHDC1 NM_001029882.3(AHDC1): c.2547delC (p.Ser850Profs) deletion Pathogenic rs587779768 GRCh37 Chromosome 1, 27876080: 27876080

Expression for Obstructive Sleep Apnea

Search GEO for disease gene expression data for Obstructive Sleep Apnea.

Pathways for Obstructive Sleep Apnea

Pathways related to Obstructive Sleep Apnea according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 ADIPOQ APOE CXCL8 IL6 INS LEP
2
Show member pathways
12.75 ADIPOQ IL6 INS LEP TNF
3
Show member pathways
12.41 ADIPOQ IGF1 INS LEP LEPR
4
Show member pathways
12.22 ACE IGF1 INS LEP REN
5 12.15 CXCL8 HTR2A IL6 TNF
6 12.07 EDN1 ICAM1 NOS3 TNF
7 11.96 CXCL8 ICAM1 IL6 TNF
8
Show member pathways
11.93 IL6 INS NOS3 TNF
9 11.92 EDN1 ICAM1 IL6 TNF
10 11.9 CXCL8 IGF1 IL6 INS
11 11.87 EDN1 IGF1 IL6 INS NOS3
12 11.85 ADIPOQ IGF1 IL6 INS LEP TNF
13 11.84 ADIPOQ IGF1 IL6 INS LEP
14 11.82 CXCL8 ICAM1 IL6 TNF
15 11.76 CXCL8 ICAM1 IL6
16 11.72 CXCL8 IL6 TNF
17 11.71 CXCL8 ICAM1 IL6 LEP SELP TNF
18 11.69 ADIPOQ LEP LEPR TNF
19 11.67 ICAM1 IL6 TNF
20
Show member pathways
11.64 CXCL8 ICAM1 IL6 TNF
21 11.57 CXCL8 EDN1 IGF1 IL6 TNF
22 11.56 CXCL8 IL6 INS
23 11.56 CXCL8 IL6 TNF
24 11.52 CXCL8 ICAM1 IL6 TNF
25 11.51 INS LEP LEPR
26 11.49 IGF1 IL6 INS
27 11.49 ICAM1 IL6 SELP TNF
28 11.45 APOE IGF1 IL6 TNF
29 11.34 ICAM1 IL6 TNF
30 11.32 CXCL8 IL6 NOS3
31
Show member pathways
11.21 CRP EDN1 LEP LEPR
32 11.1 CXCL8 EDN1 ICAM1 IL6 NOS3 TNF
33 11.05 ADIPOQ IL6 LEP TNF
34 11.04 CXCL8 ICAM1 IL6 SELP TNF
35 10.9 CRP CXCL8 IL6 TNF

GO Terms for Obstructive Sleep Apnea

Cellular components related to Obstructive Sleep Apnea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ACE ADIPOQ APOE CHI3L1 CRP CXCL8
2 external side of plasma membrane GO:0009897 9.55 ACE ICAM1 IL6 SELP TNF
3 extracellular space GO:0005615 9.5 ACE ADIPOQ APOE CHI3L1 CRP CXCL8

Biological processes related to Obstructive Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CHI3L1 HTR2A ICAM1 IL6 TNF
2 response to lipopolysaccharide GO:0032496 9.97 EDN1 ICAM1 IL6 REN SELP
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 ICAM1 IL6 INS TNF
4 cellular response to lipopolysaccharide GO:0071222 9.95 CXCL8 ICAM1 IL6 TNF
5 response to insulin GO:0032868 9.9 ICAM1 IL6 LEP
6 response to glucocorticoid GO:0051384 9.9 ADIPOQ IL6 TNF
7 cellular response to drug GO:0035690 9.9 ADIPOQ EDN1 REN
8 positive regulation of MAPK cascade GO:0043410 9.9 IGF1 IL6 INS LEP
9 response to nutrient levels GO:0031667 9.88 ADIPOQ IL6 LEP
10 positive regulation of MAP kinase activity GO:0043406 9.88 EDN1 HTR2A TNF
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 IGF1 INS LEP SELP
12 response to heat GO:0009408 9.85 IGF1 IL6 NOS3
13 negative regulation of fat cell differentiation GO:0045599 9.85 ADIPOQ IL6 TNF
14 cellular response to tumor necrosis factor GO:0071356 9.85 CHI3L1 CXCL8 EDN1 ICAM1 IL6
15 response to activity GO:0014823 9.84 ADIPOQ EDN1 LEP
16 positive regulation of DNA replication GO:0045740 9.84 IGF1 IL6 INS
17 glucose metabolic process GO:0006006 9.84 ADIPOQ INS LEP TNF
18 glucose homeostasis GO:0042593 9.83 ADIPOQ IL6 INS LEP LEPR
19 acute-phase response GO:0006953 9.82 CRP IL6 INS
20 response to amino acid GO:0043200 9.81 EDN1 ICAM1 IL6
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 EDN1 IGF1 IL6 TNF
22 phosphatidylinositol 3-kinase signaling GO:0014065 9.8 EDN1 HTR2A IGF1
23 positive regulation of protein kinase B signaling GO:0051897 9.8 CHI3L1 IL6 INS LEP TNF
24 positive regulation of glucose import GO:0046326 9.79 ADIPOQ IGF1 INS
25 positive regulation of mitotic nuclear division GO:0045840 9.79 EDN1 IGF1 INS
26 cellular response to interleukin-1 GO:0071347 9.77 CHI3L1 CXCL8 EDN1 ICAM1 IL6
27 negative regulation of glucose import GO:0046325 9.74 LEP TNF
28 positive regulation of glycolytic process GO:0045821 9.74 HTR2A IGF1 INS
29 response to dietary excess GO:0002021 9.73 APOE LEP
30 sexual reproduction GO:0019953 9.73 LEP LEPR
31 neutrophil mediated immunity GO:0002446 9.73 ACE IL6
32 response to leptin GO:0044321 9.73 EDN1 LEPR
33 leptin-mediated signaling pathway GO:0033210 9.72 LEP