MCID: OCL020
MIFTS: 44

Ocular Cicatricial Pemphigoid malady

Rare diseases category

Aliases & Classifications for Ocular Cicatricial Pemphigoid

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Ocular Cicatricial Pemphigoid, Aliases & Descriptions:

Name: Ocular Cicatricial Pemphigoid 41 43 60
Cicatricial Pemphigoid, Ocular 41
 
Pemphigoid, Ocular Cicatricial 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Ocular Cicatricial Pemphigoid

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MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as cicatricial pemphigoid, ocular, is related to cicatricial pemphigoid and conjunctivitis, and has symptoms including autosomal dominant inheritanceand abnormality of the eye. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are Cell junction organization and Alpha6-Beta4 Integrin Signaling Pathway. The compounds unicap and beclomethasone dipropionate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are normal and limbs/digits/tail.

Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1cicatricial pemphigoid32.3DST, ITGA6, ITGB4, CD79A
2conjunctivitis31.3RNASE3, CD79A
3bullous pemphigoid31.3ITGA6, DST
4pemphigus31.2DST, CD79A
5keratoconjunctivitis31.1RNASE3, IL5
6rheumatoid arthritis30.9HLA-DRB1, CIITA
7pemphigus vulgaris30.9HLA-DRB1, CIITA, DST
8arthritis29.1HLA-DRB1, TNF, TGFB1, CIITA, MIF, IL4
9cataract10.6
10entropion10.6
11collagenous colitis10.6RNASE3
12kindler syndrome10.6ITGB4
13strongyloidiasis10.5IL5
14giardiasis10.5CD79A
15amebiasis10.5CD79A
16paragonimiasis10.5IL5
17eosinophilic gastroenteritis10.5IL5
18eosinophilia-myalgia syndrome10.5IL5
19exanthem10.5CD79A
20cryptosporidiosis10.5CD79A
21epidermolysis bullosa with pyloric atresia10.5ITGA6, ITGB4
22leprosy10.5HLA-DRB1
23keratitis10.4
24bronchitis10.4RNASE3, CD79A
25aspergillosis10.4CD79A, CSF1
26blau syndrome10.4TNF
27henoch-schoenlein purpura10.4RNASE3, CD79A
28chronic eosinophilic pneumonia10.4IL5, RNASE3
29giant papillary conjunctivitis10.4RNASE3, IL5
30parasitic helminthiasis infectious disease10.4RNASE3, IL5
31onchocerciasis10.4RNASE3, IL5
32churg-strauss syndrome10.4RNASE3, IL5
33herpes gestationis10.4DST, RNASE3
34eosinophilic pneumonia10.4RNASE3, IL5
35gastroenteritis10.3CD79A
36epidermolysis bullosa simplex10.3DST, ITGB4
37membranous glomerulonephritis, antenatal10.3CD79A, CTGF
38periapical granuloma10.3IL4
39junctional epidermolysis bullosa10.3DST, ITGA6, ITGB4
40bullous skin disease10.3DST, IL5
41epidermolysis bullosa10.3ITGB4, ITGA6, DST
42immunoglobulin alpha deficiency10.3HLA-DQB1, CD79A
43kimura disease10.3IL5, PRG2, RNASE3
44bronchiectasis10.3RNASE3, CD79A
45hypereosinophilic syndrome10.3RNASE3, PRG2, IL5
46epidermolysis bullosa acquisita10.3CD79A, ITGB4, DST
47dermatitis herpetiformis10.3CD79A, HLA-DQB1
48porphyria cutanea tarda10.3
49wegener granulomatosis10.3
50neutropenia10.3

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms for Ocular Cicatricial Pemphigoid

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HPO human phenotypes related to Ocular Cicatricial Pemphigoid:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the eye HP:0000478

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

31
Eye, Testes, T cells

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

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MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CTGF, CD79A, IL4, MIF, CIITA, HLA-DQB1
2MP:00053718.4TNF, SERPINH1, DST, ITGA6, CSF1, CTGF
3MP:00020068.2TNF, TGFB1, MIF, ITGA6, IL5
4MP:00053678.0HLA-DQB1, TGFB1, DST, ITGA6, ITGB4, IL4
5MP:00053807.8TNF, TGFB1, SERPINH1, ITGA6, IL5, CTGF
6MP:00053857.6HLA-DQB1, TNF, TGFB1, SERPINH1, ITGA6, ITGB4
7MP:00053827.6TNF, TGFB1, SERPINH1, ITGA6, ITGB4, IL4
8MP:00053707.5HLA-DQB1, TNF, TGFB1, IL4, IL5, CSF1
9MP:00053797.5HLA-DQB1, TNF, TGFB1, CIITA, ITGA6, IL4
10MP:00053917.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
11MP:00107717.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
12MP:00053897.1HLA-DQB1, TNF, TGFB1, DST, IL4, IL5
13MP:00053867.1HLA-DQB1, TNF, TGFB1, DST, ITGB4, IL5
14MP:00053846.8HLA-DQB1, TNF, TGFB1, MIF, ITGA6, ITGB4
15MP:00053816.8SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
16MP:00036316.7SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
17MP:00107686.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
18MP:00053786.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
19MP:00053886.3CTGF, HLA-DQB1, TNF, TGFB1, SERPINH1, PRG2
20MP:00053766.1DST, CIITA, TGFB1, TNF, HLA-DQB1, MIF
21MP:00053876.0PRG2, CIITA, TGFB1, TNF, HLA-DQB1, MIF
22MP:00053975.8DST, CIITA, TGFB1, TNF, HLA-DQB1, PRG2

Publications for Ocular Cicatricial Pemphigoid

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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
2
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
3
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
4
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
5
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
6
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
7
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
8
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
9
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
10
Ocular cicatricial pemphigoid. (18762085)
2008
11
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
12
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
13
Ocular cicatricial pemphigoid. (16954792)
2006
14
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
15
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
16
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
17
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
18
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
19
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
20
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
21
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
22
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
23
The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. (10946315)
2000
24
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
25
Linear IgA dermatosis mimicking ocular cicatricial pemphigoid. (10555732)
1999
26
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
27
Pure ocular cicatricial pemphigoid. A distinct immunopathologic subset of cicatricial pemphigoid. (9951490)
1999
28
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
29
Treatment of ocular cicatricial pemphigoid with intravenous gammaglobulin. (9689316)
1998
30
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
31
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
32
Conjunctival scarring after eyelid surgery as first sign of ocular cicatricial pemphigoid. (9076789)
1997
33
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
34
Conjunctival fibrosis in ocular cicatricial pemphigoid--the role of cytokines. (9268585)
1997
35
Progression of disease in ocular cicatricial pemphigoid. (8703876)
1996
36
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid. (8759268)
1996
37
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
38
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
39
Ocular cicatricial pemphigoid. A case report of monozygotic twins discordant for the disease. (7864752)
1995
40
Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. (9097741)
1995
41
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
42
Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid. (7800360)
1994
43
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
44
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
45
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
46
Ocular cicatricial pemphigoid and oesophageal carcinoma. (2203219)
1990
47
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
48
Ocular cicatricial pemphigoid with granular IgA and complement deposition. (3904684)
1985
49
Enigma of ocular cicatricial pemphigoid. A comparative study of clinical and immunological findings. (398602)
1979
50
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DST, ITGA6, ITGB4
2
Show member pathways
9.7DST, ITGA6, ITGB4
39.6IL5, IL4
49.4CIITA, IL4, CD79A
5
Show member pathways
9.4SERPINH1, DST, ITGA6, ITGB4
6
Show member pathways
Proteogylcan syndecan-mediated signaling events36
9.4ITGB4, ITGA6, TGFB1
79.4HLA-DQB1, HLA-DRB1, ITGA6
89.3IL4, TGFB1
99.3CSF1, TNF
10
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.3CD79A, HLA-DRB1, HLA-DQB1
119.2ITGA6, ITGB4, IL4, CSF1
12
Show member pathways
9.2HLA-DQB1, HLA-DRB1, ITGA6, ITGB4
13
Show member pathways
9.0IL5, CIITA, HLA-DRB1, HLA-DQB1
149.0TGFB1, TNF
159.0IL5, IL4, TGFB1
16
Show member pathways
8.9TGFB1, PRG2, ITGA6, ITGB4
17
Show member pathways
8.9ITGB4, ITGA6, PRG2, TGFB1
18
Show member pathways
8.8TGFB1, SERPINH1, DST, ITGA6, ITGB4
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.8IL5, IL4, TNF
208.8TNF, IL4, IL5
218.7TNF, TGFB1, MIF
228.7TNF, TGFB1, CSF1
23
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
8.6ITGB4, ITGA6, TGFB1, TNF
24
Show member pathways
8.6TNF, TGFB1, ITGA6, ITGB4
25
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.5TNF, IL4, IL5, CD79A
26
Show member pathways
8.3TNF, TGFB1, ITGA6, ITGB4, CTGF
278.2TNF, TGFB1, MIF, IL4
288.2TGFB1, TNF, HLA-DRB1, HLA-DQB1
29
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TNF, CIITA, IL4
30
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TGFB1, ITGA6, ITGB4, CD79A
31
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TNF, IL4, CD79A
327.9HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA
33
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.9TNF, TGFB1, IL4, IL5, CD79A
347.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, CSF1
357.8HLA-DRB1, TNF, ITGA6, IL4, IL5, CSF1
36
Show member pathways
7.6TNF, TGFB1, IL4, IL5, CSF1, CTGF
37
Show member pathways
7.6TNF, TGFB1, MIF, IL4, IL5, CSF1
38
Show member pathways
7.5TNF, TGFB1, ITGA6, ITGB4, IL4, IL5
397.4HLA-DRB1, TNF, TGFB1, IL4, IL5, CSF1
40
Show member pathways
7.1TNF, TGFB1, ITGA6, ITGB4, IL4, IL5
41
Show member pathways
6.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA, ITGA6
42
Show member pathways
6.6TNF, TGFB1, PRG2, ITGA6, ITGB4, IL4
43
Show member pathways
6.3IL5, HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

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Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1unicap439.9CD79A, IL5, RNASE3
2beclomethasone dipropionate439.7CSF1, IL5, RNASE3
3sodium cromoglycate439.6CD79A, IL5, RNASE3
4salbutamol43 49 28 24 1213.6CD79A, RNASE3, IL5, CSF1
5nedocromil sodium439.4IL4, CSF1, IL5, RNASE3
6praziquantel43 1210.4RNASE3, IL4, IL5, CD79A
7ltc4439.4IL5, RNASE3, CSF1, PRG2
8anti-fungal439.4RNASE3, CD79A, CSF1, IL5
9glatiramer acetate43 1210.3IL5, HLA-DRB1, CIITA, IL4
10pranlukast43 28 1210.9IL5, TNF, IL4, RNASE3
11methylcellulose438.9IL4, TGFB1, CSF1, IL5
12prednisolone43 28 1210.8RNASE3, TNF, CSF1, CD79A, IL5
13thyroxine43 249.7CIITA, TGFB1, IL5, IL4, CD79A
14polyinosinic-polycytidylic acid438.7TNF, CIITA, IL4, IL5, CSF1
15n-formylmethionyl-leucylphenylalanine438.6IL5, RNASE3, TNF, CSF1
16budesonide43 49 1210.6RNASE3, IL4, CSF1, IL5, TNF
17fluticasone propionate43 49 59 1211.6TNF, RNASE3, IL4, IL5, CSF1
18ivig438.6TNF, IL5, CSF1, CD79A, IL4
19herbimycin a43 599.5IL5, MIF, TNF, IL4, ITGA6
20fmlp438.4TNF, CSF1, RNASE3, PRG2, IL5
21methacholine43 49 1210.3PRG2, IL4, CD79A, IL5, TGFB1, RNASE3
22n acetylcysteine438.3CTGF, CD79A, CSF1, IL4, RNASE3, TNF
23allergens438.3HLA-DRB1, CIITA, RNASE3, PRG2, IL4, CD79A
24gm-csf43 289.3IL5, TNF, TGFB1, CSF1, IL4
25il 10438.2TNF, TGFB1, IL4, IL5, CSF1
26h2o2438.2IL5, MIF, CTGF, TNF, RNASE3, CSF1
27carbamazepine43 49 1210.2TNF, IL4, IL5, CD79A
28paraffin438.1IL5, TGFB1, DST, MIF, IL4, CD79A
29methotrexate49 43 1210.1TNF, CD79A, IL5, ITGA6, TGFB1, HLA-DRB1
30nitric oxide43 24 1210.0RNASE3, PRG2, CTGF, MIF, ITGB4, SERPINH1
31cysteine438.0CIITA, CTGF, IL4, MIF, PRG2, CSF1
32lactate438.0TNF, RNASE3, MIF, CD79A, CTGF, TGFB1
33sb 20358043 599.0TGFB1, MIF, IL4, IL5, CTGF, TNF
34tacrolimus43 49 129.9IL5, CD79A, IL4, TGFB1, TNF
35ly294002437.9TGFB1, IL4, CSF1, TNF, IL5, CTGF
36arginine437.8CD79A, CSF1, IL5, IL4, RNASE3, PRG2
37actinomycin d437.7TGFB1, CIITA, PRG2, IL4, CSF1, TNF
38rantes437.5IL4, TNF, TGFB1, CIITA, RNASE3, CSF1
39thymidine43 248.5CIITA, IL5, TNF, TGFB1, MIF, IL4
40indomethacin43 28 59 1210.4TGFB1, TNF, PRG2, IL4, IL5, CSF1
41serine437.4ITGB4, TGFB1, CTGF, TNF, CIITA, CSF1
42cycloheximide437.4DST, CSF1, IL4, TGFB1, TNF, IL5
43cyclosporin a43 28 599.3CTGF, TGFB1, TNF, SERPINH1, CIITA, CD79A
44oligonucleotide437.3PRG2, ITGA6, RNASE3, DST, SERPINH1, CIITA
45histamine43 28 249.2IL5, IL4, CD79A, CSF1, TNF, TGFB1
46pge2437.0TGFB1, CD79A, CSF1, IL5, IL4, MIF
47dexamethasone43 49 28 129.9TGFB1, TNF, CSF1, CIITA, RNASE3, MIF
48retinoic acid43 247.7ITGA6, TGFB1, IL5, TNF, ITGB4, RNASE3
49vegf436.7TNF, CD79A, CSF1, CTGF, IL5, IL4
50tyrosine436.6CTGF, CSF1, HLA-DRB1, CIITA, IL4, SERPINH1

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:00300569.8DST, ITGA6, ITGB4
2basal plasma membraneGO:00099259.8ITGB4, ITGA6, DST
3MHC class II protein complexGO:00426139.6HLA-DRB1, HLA-DQB1
4basement membraneGO:00056049.4ITGB4, ITGA6, DST
5cell surfaceGO:00099868.4TNF, TGFB1, CIITA, MIF, ITGB4
6external side of plasma membraneGO:00098978.3HLA-DRB1, TNF, ITGA6, IL4, CD79A
7extracellular regionGO:00055767.4TNF, TGFB1, RNASE3, PRG2, MIF, IL5
8extracellular spaceGO:00056157.3CTGF, CSF1, IL5, IL4, MIF, SERPINH1
9plasma membraneGO:00058866.7HLA-DQB1, HLA-DRB1, TNF, TGFB1, ITGA6, ITGB4

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell motilityGO:004887010.1ITGB4, DST
2cell-matrix adhesionGO:000716010.1ITGA6, ITGB4, CTGF
3filopodium assemblyGO:004684710.1ITGA6, ITGB4
4positive regulation of phosphorylationGO:004232710.1ITGA6, MIF
5hemidesmosome assemblyGO:003158110.1ITGB4, ITGA6, DST
6positive regulation of MHC class II biosynthetic processGO:004534810.1IL4, CIITA
7immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DRB1, HLA-DQB1
8humoral immune response mediated by circulating immunoglobulinGO:00024559.9HLA-DQB1, HLA-DRB1
9integrin-mediated signaling pathwayGO:00072299.8DST, ITGA6, ITGB4, CTGF
10positive regulation of cellular protein metabolic processGO:00322709.8CSF1, TGFB1
11interferon-gamma-mediated signaling pathwayGO:00603339.7HLA-DQB1, HLA-DRB1, CIITA
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:020003439.7MIF, TNF
13positive regulation of B cell proliferationGO:00308909.7MIF, IL4, IL5
14positive regulation of podosome assemblyGO:00718039.7IL5, TNF
15positive regulation of collagen biosynthetic processGO:00329679.6TGFB1, CTGF
16positive regulation of osteoclast differentiationGO:00456729.5TNF, CSF1
17positive regulation of gene expressionGO:00106289.5TGFB1, CSF1, CTGF
18positive regulation of chemokine biosynthetic processGO:00450809.5TNF, IL4
19negative regulation of gene expressionGO:00106299.4CTGF, MIF, TNF
20cytokine-mediated signaling pathwayGO:00192219.4HLA-DQB1, HLA-DRB1, CIITA, IL5
21response to woundingGO:00096119.4TGFB1, DST, ITGB4, CTGF
22positive regulation of ERK1 and ERK2 cascadeGO:00703749.4CTGF, MIF, TNF
23positive regulation of cytokine secretionGO:00507159.4MIF, TNF
24positive regulation of protein complex assemblyGO:00313349.3TGFB1, TNF
25cellular response to organic cyclic compoundGO:00714079.2ITGA6, TGFB1, TNF
26positive regulation of MAP kinase activityGO:00434069.1MIF, TGFB1, TNF
27positive regulation of peptidyl-serine phosphorylationGO:00331389.1MIF, TGFB1, TNF
28positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1TNF, IL4, IL5
29osteoclast differentiationGO:00303169.0CSF1, TNF
30positive regulation of protein phosphorylationGO:00019349.0TNF, TGFB1, CTGF
31protein import into nucleus, translocationGO:00000608.9TNF, TGFB1
32negative regulation of transcription, DNA-templatedGO:00458928.5IL4, CIITA, TGFB1, TNF
33immune responseGO:00069558.4HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL4, IL5
34extracellular matrix organizationGO:00301988.4TNF, TGFB1, SERPINH1, DST, ITGA6, ITGB4
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.4IL4, ITGA6, CIITA, TGFB1, TNF
36positive regulation of transcription, DNA-templatedGO:00458938.3TNF, TGFB1, CIITA, IL4, IL5
37inflammatory responseGO:00069548.3CSF1, IL5, MIF, CIITA, TGFB1, TNF

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.5DST, ITGA6, CTGF
2MHC class II receptor activityGO:00323959.3HLA-DRB1, HLA-DQB1
3growth factor activityGO:00080838.5CTGF, CSF1, IL5, IL4, TGFB1
4cytokine activityGO:00051258.2TNF, MIF, IL4, IL5, CSF1
5protein bindingGO:00055156.6TGFB1, CIITA, DST, MIF, ITGA6, ITGB4

Products for genes affiliated with Ocular Cicatricial Pemphigoid

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  • Antibodies
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Sources for Ocular Cicatricial Pemphigoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet