MCID: OCL020
MIFTS: 44

Ocular Cicatricial Pemphigoid malady

Summaries for Ocular Cicatricial Pemphigoid

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33MalaCards
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MalaCards: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to cicatricial pemphigoid and bullous pemphigoid. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are HTLV-I infection and Hypertrophic cardiomyopathy (HCM). The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are vision/eye and embryogenesis.

Aliases & Classifications for Ocular Cicatricial Pemphigoid

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

ocular cicatricial pemphigoid 43 45 61
pemphigoid, benign mucous membrane 61
pemphigoid, ocular cicatricial 43
cicatricial pemphigoid, ocular 43


Related Diseases for Ocular Cicatricial Pemphigoid

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1cicatricial pemphigoid32.0ITGA6, DST, ITGB4, CD79A
2bullous pemphigoid30.6DST, ITGA6
3pemphigus30.6DST, CD79A
4pemphigus vulgaris30.6CIITA, DST, HLA-DRB1
5sjogren's syndrome30.4CIITA, CD79A
6arthritis30.3IL4, MIF, HLA-DRB1, TNF, CSF1, TGFB1
7stevens-johnson syndrome10.7
8cicatricial entropion10.6
9mucous membrane pemphigoid10.4
10brunsting-perry syndrome10.3
11porphyria cutanea tarda10.3
12trachoma10.3
13n syndrome10.3
14mucoepidermoid carcinoma10.3
15micro syndrome10.3
16mast syndrome10.3
17atopic keratoconjunctivitis10.3
18neuritis10.0CIITA
19alopecia areata10.0CIITA
20kawasaki disease10.0CIITA
21vitiligo10.0CIITA
22myocarditis10.0CIITA
23encephalitis10.0CIITA
24cervical intraepithelial neoplasia10.0ITGB4
25cystic fibrosis10.0RNASE3
26myositis10.0CIITA
27lyme disease10.0CIITA
28bronchopulmonary dysplasia10.0RNASE3
29adult t-cell leukemia10.0SERPINH1
30wegener's granulomatosis10.0CIITA
31diabetic retinopathy10.0CTGF
32collagenous colitis10.0RNASE3
33rhabdomyosarcoma10.0CTGF
34neutropenia10.0CSF1
35glaucoma10.0CTGF
36sarcoma10.0CSF1
37malignant mesothelioma10.0RNASE3
38acute pancreatitis10.0MIF
39stroke, ischemic10.0CSF1
40systemic scleroderma10.0CTGF
41eosinophilic esophagitis10.0IL5
42acute leukemia10.0CSF1
43bacterial vaginosis10.0SERPINH1
44eosinophilic gastroenteritis10.0IL5
45purpura10.0CD79A
46strongyloidiasis10.0IL5
47cervical cancer10.0HLA-DQB1
48paraneoplastic syndromes10.0CTGF
49toxoplasmosis10.0CD79A
50nephrotic syndrome10.0CD79A

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Clinical Features for Ocular Cicatricial Pemphigoid

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ocular Cicatricial Pemphigoid

Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Search CenterWatch for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

Anatomical Context for Ocular Cicatricial Pemphigoid

Sources:
33MalaCards
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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

33
T cells, B cells

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.1DST, ITGB4
2MP:00053809.7SERPINH1, ITGA6, CTGF
3MP:00053679.7HLA-DQB1, ITGB4, DST
4MP:00053719.7CSF1, DST, SERPINH1
5MP:00053899.2TGFB1, DST, CSF1
6MP:00107719.1CTGF, ITGB4, ITGA6, DST, TGFB1
7MP:00053888.4TGFB1, CTGF, HLA-DQB1, ITGB4, ITGA6, PRG2
8MP:00036318.4CSF1, HLA-DQB1, ITGB4, ITGA6, DST, SERPINH1
9MP:00053798.0CSF1, TNF, ITGA6, CIITA, IL4, TGFB1
10MP:00053827.7CSF1, TNF, CTGF, ITGB4, ITGA6, IL4
11MP:00053857.6CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
12MP:00053707.6CSF1, TNF, HLA-DQB1, IL5, IL4, TGFB1
13MP:00053817.0TNF, CTGF, HLA-DQB1, ITGB4, ITGA6, DST
14MP:00053786.7CSF1, TNF, CTGF, HLA-DQB1, ITGA6, DST
15MP:00053846.7CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
16MP:00107686.4CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
17MP:00053766.2ITGB4, HLA-DQB1, CTGF, TNF, CSF1, CIITA
18MP:00053876.2ITGA6, ITGB4, HLA-DQB1, TNF, CSF1, CIITA
19MP:00053976.0CIITA, ITGA6, HLA-DQB1, TNF, CSF1, PRG2

Publications for Ocular Cicatricial Pemphigoid

Sources:
51PubMed
See all sources

Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Coexistence of ocular cicatricial pemphigoid with Stevens Johnson syndrome. (23826544)
2013
2
Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. (21279976)
2011
3
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
4
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
5
T-helper 17 lymphocytes in ocular cicatricial pemphigoid. (19641634)
2009
6
Ocular cicatricial pemphigoid. (18762085)
2008
7
Exacerbation of undiagnosed ocular cicatricial pemphigoid after repair of involutional entropion. (18356734)
2008
8
Ocular manifestations in a case of childhood cicatricial pemphigoid. (18609489)
2008
9
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
10
Treatment of ocular cicatricial pemphigoid with the tumour necrosis factor alpha antagonist etanercept. (17225020)
2007
11
Ocular involvement in anti-epiligrin cicatricial pemphigoid. (17191196)
2006
12
Ocular cicatricial pemphigoid: manifestations and management. (15967079)
2005
13
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
14
A nonrandomized comparison of the clinical outcome of ocular involvement in patients with mucous membrane (cicatricial) pemphigoid between conventional immunosuppressive and intravenous immunoglobulin therapies. (15183151)
2004
15
Blood group related antigens in ocular cicatricial pemphigoid. (15377543)
2004
16
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
17
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
18
Ocular cicatricial pemphigoid. (12568651)
2003
19
Ocular cicatricial pemphigoid: all conjunctival scarring is not trachoma. (14750630)
2003
20
Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. (12882790)
2003
21
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
22
Identification of ocular cicatricial pemphigoid antibody binding site(s) in human beta4 integrin. (11157870)
2001
23
Influence of intravenous immunoglobulin therapy on serum levels of anti-beta 4 antibodies in ocular cicatricial pemphigoid. A correlation with disease activity. A preliminary study. (11148601)
2000
24
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
25
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
26
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
27
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
28
Costimulatory molecules in ocular cicatricial pemphigoid. (9579477)
1998
29
Immunohistopathologic testing in patients suspected of ocular cicatricial pemphigoid. (9723998)
1998
30
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
31
Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. (9008223)
1997
32
Limbal conjunctival Langerhans cell density in ocular cicatricial pemphigoid: an indirect immunofluorescence study on Dispase-split conjunctiva. (9255511)
1997
33
Anterior lamellar repositioning and grey line split for upper lid entropion in ocular cicatricial pemphigoid. (8944093)
1996
34
Coexistence of pemphigus vulgaris and ocular cicatricial pemphigoid. (8621820)
1996
35
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8659597)
1996
36
Inferior retractor plication surgery for lower lid entropion with trichiasis in ocular cicatricial pemphigoid. (8534641)
1995
37
Serum levels of tumor necrosis factor-alpha and interleukin-6 in ocular cicatricial pemphigoid. (8258509)
1993
38
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
39
Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid. (1763074)
1991
40
Cicatricial pemphigoid diagnosed from ocular features in recurrent severe vulval scarring. Two case reports. (2059597)
1991
41
Ocular cicatricial pemphigoid. (2202335)
1990
42
Cataract surgery in ocular cicatricial pemphigoid. (3050692)
1988
43
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
44
T and B lymphocytes in ocular cicatricial pemphigoid. (7027799)
1981
45
Enigma of ocular cicatricial pemphigoid. A comparative study of clinical and immunological findings. (398602)
1979
46
HLA antigens in ocular cicatricial pemphigoid. (369492)
1979
47
The acute manifestations of ocular cicatricial pemphigoid: diagnosis and treatment. (537759)
1979
48
HLA antigens in ocular cicatricial pemphigoid. (348231)
1978
49
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976
50
Ocular cicatricial pemphigoid (immunologic studies). (798368)
1976

Genetic Variations for Ocular Cicatricial Pemphigoid

Expression for genes affiliated with Ocular Cicatricial Pemphigoid

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ocular Cicatricial Pemphigoid

Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1HLA-DQB1
2
Hide members
10.0ITGA6, ITGB4
39.9HLA-DRB1
4
Hide members
9.9CSF1, IL5
59.7IL4, IL5
69.6ITGB4, ITGA6, DST
79.6ITGA6, ITGB4, DST
8
Hide members
9.4DST, SERPINH1, ITGB4, ITGA6
99.3IL4, ITGA6, ITGB4, CSF1
10
Hide members
9.2CTGF, TGFB1, ITGA6, ITGB4
11
Hide members
9.2ITGB4, CTGF, ITGA6, PRG2
12
Immune response NFAT in immune response
Hide members
9.1CD79A, HLA-DRB1, HLA-DQB1
139.1TGFB1, TNF
14
Hide members
9.1ITGA6, HLA-DQB1, HLA-DRB1, ITGB4
15
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9.0IL5, CTGF, TGFB1, CSF1
16
Hide members
9.0HLA-DQB1, IL5, CIITA, HLA-DRB1
17
Hide members
8.9IL4, TNF, IL5
188.9TNF, IL4, IL5
19
Hide members
8.7HLA-DQB1, HLA-DRB1, ITGA6, CIITA, IL5
208.7IL4, TGFB1, TNF
21
Hide members
8.6PRG2, ITGB4, IL5, CSF1, ITGA6, CTGF
22
Hide members
8.5TNF, CD79A, IL5, IL4
23
Hide members
8.5IL5, TNF, CD79A, IL4
24
Hide members
8.0TNF, HLA-DRB1, CIITA, IL4, HLA-DQB1
257.9HLA-DRB1, HLA-DQB1, TNF, TGFB1, CIITA
26
Hide members
7.9TGFB1, ITGB4, HLA-DRB1, HLA-DQB1, CTGF, CD79A
27
Hide members
7.9HLA-DRB1, HLA-DQB1, IL4, TNF, CD79A
287.7IL4, ITGA6, IL5, HLA-DRB1, TNF, CSF1
29
Hide members
7.6IL4, TGFB1, ITGA6, IL5, ITGB4, TNF
30
Hide members
7.3ITGA6, CSF1, TNF, CTGF, ITGB4, IL5
31
Hide members
6.9CIITA, HLA-DRB1, IL5, HLA-DQB1, PRG2, IL4

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5DST
2pge24510.4TGFB1
3ivig4510.2CSF1, CD79A
4gm-csf45 2911.1TNF
5beclomethasone dipropionate459.9RNASE3, CSF1, IL5
6unicap459.9IL5, RNASE3, CD79A
7h2o2459.9CD79A, CTGF, MIF
8indomethacin45 60 29 1112.7CSF1, IL5, PRG2
9sodium cromoglycate459.7CD79A, IL5, RNASE3
10nedocromil sodium459.5IL5, RNASE3, CSF1, IL4
11cyclosporin a45 29 6011.5CTGF, RNASE3, CIITA, CD79A, SERPINH1
12salbutamol45 50 29 11 2413.5IL5, CD79A, RNASE3, CSF1
13kalinin459.5ITGB4, ITGA6, DST
14praziquantel45 1110.4IL5, RNASE3, CD79A, IL4
15ltc4459.4PRG2, IL5, RNASE3, CSF1
16anti-fungal459.4IL5, RNASE3, CD79A, CSF1
17glatiramer acetate45 1110.2HLA-DRB1, CIITA, IL4, IL5
18fmlp459.2CSF1, RNASE3, IL5, PRG2
19methylcellulose459.1TGFB1, IL4, IL5, CSF1
20pranlukast45 29 1111.0IL5, RNASE3, TNF, IL4
21dexamethasone45 50 29 1111.9IL5, RNASE3, TGFB1, CD79A, CTGF, CIITA
22n-formylmethionyl-leucylphenylalanine458.8TNF, RNASE3, IL5, CSF1
23thyroxine45 249.8CIITA, IL4, CD79A, TGFB1, IL5
24polyinosinic-polycytidylic acid458.8IL4, IL5, CIITA, CSF1, TNF
25budesonide45 50 1110.7TNF, CSF1, RNASE3, IL4, IL5
26fluticasone propionate45 50 60 1111.7IL4, RNASE3, CSF1, TNF, IL5
27prednisolone45 29 1110.7CSF1, CD79A, RNASE3, IL5, TNF
28herbimycin a45 609.7MIF, IL5, IL4, ITGA6, TNF
29carbamazepine45 50 1110.5TNF, CD79A, IL5, IL4
30methacholine45 119.5IL5, CD79A, RNASE3, IL4, PRG2, TGFB1
31il 10458.5CSF1, TNF, TGFB1, IL4, IL5
32rantes458.3IL4, CIITA, CSF1, TNF, RNASE3, TGFB1
33n acetylcysteine458.3CD79A, IL4, TNF, CSF1, CTGF, RNASE3
34paraffin458.2IL4, IL5, TGFB1, DST, CSF1, MIF
35allergens458.2IL4, IL5, RNASE3, CD79A, PRG2, CIITA
36sb 20358045 609.1CTGF, MIF, TNF, IL5, IL4, TGFB1
37ly294002458.1CTGF, TGFB1, IL4, CSF1, TNF, IL5
38lactate458.0CSF1, CTGF, MIF, CD79A, RNASE3, TGFB1
39nitric oxide45 11 2410.0SERPINH1, PRG2, TNF, RNASE3, MIF, CIITA
40methotrexate45 50 1110.0ITGA6, IL5, TNF, TGFB1, HLA-DRB1, CD79A
41cysteine457.9CSF1, IL4, IL5, CD79A, MIF, CIITA
42actinomycin d457.9CIITA, CSF1, TNF, PRG2, IL4, TGFB1
43serine457.8TGFB1, MIF, CIITA, ITGB4, TNF, CSF1
44thymidine45 248.7CSF1, TNF, CTGF, IL5, IL4, TGFB1
45tacrolimus45 50 119.7TGFB1, IL4, CD79A, IL5, TNF
46histamine45 29 249.3PRG2, CD79A, RNASE3, IL4, CSF1, TGFB1
47oligonucleotide457.3TGFB1, CTGF, SERPINH1, RNASE3, DST, PRG2
48vegf456.8CD79A, MIF, ITGA6, CTGF, CSF1, TNF
49retinoic acid45 247.8ITGA6, PRG2, MIF, CD79A, RNASE3, IL5
50tyrosine456.6IL5, IL4, SERPINH1, MIF, PRG2, RNASE3

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

Sources:
16Gene Ontology
See all sources

Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:0300569.7DST, ITGA6, ITGB4
2basal plasma membraneGO:0099259.5DST, ITGA6, ITGB4
3basement membraneGO:0056049.3ITGB4, ITGA6, DST
4external side of plasma membraneGO:0098978.0TNF, HLA-DRB1, ITGA6, CD79A, IL4
5extracellular regionGO:0055767.5TGFB1, IL5, RNASE3, MIF, PRG2, CTGF
6extracellular spaceGO:0056157.4TGFB1, CSF1, TNF, CTGF, MIF, IL5

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.0CIITA, IL4
2hemidesmosome assemblyGO:03158110.0DST, ITGA6, ITGB4
3cell-matrix adhesionGO:0071609.9ITGA6, ITGB4, CTGF
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DQB1
5positive regulation of B cell proliferationGO:0308909.8IL4, IL5, MIF
6positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7MIF, TNF
7integrin-mediated signaling pathwayGO:0072299.7CTGF, ITGB4, ITGA6, DST
8humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
9positive regulation of podosome assemblyGO:0718039.6IL5, TNF
10positive regulation of cellular protein metabolic processGO:0322709.6TGFB1, CSF1
11interferon-gamma-mediated signaling pathwayGO:0603339.5CIITA, HLA-DRB1, HLA-DQB1
12response to woundingGO:0096119.4CTGF, ITGB4, DST, TGFB1
13positive regulation of chemokine biosynthetic processGO:0450809.4TNF, IL4
14negative regulation of gene expressionGO:0106299.3MIF, CTGF, TNF
15cytokine-mediated signaling pathwayGO:0192219.3HLA-DQB1, HLA-DRB1, CIITA, IL5
16positive regulation of MAP kinase activityGO:0434069.2TNF, MIF, TGFB1
17positive regulation of peptidyl-serine phosphorylationGO:0331389.2TGFB1, MIF, TNF
18positive regulation of ERK1 and ERK2 cascadeGO:0703749.1TNF, CTGF, MIF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0TNF, IL5, IL4
20positive regulation of protein phosphorylationGO:0019348.9TGFB1, CTGF, TNF
21positive regulation of protein complex assemblyGO:0313348.8TGFB1, TNF
22inflammatory responseGO:0069548.6CSF1, TNF, MIF, IL5, TGFB1
23extracellular matrix organizationGO:0301988.4TGFB1, SERPINH1, DST, ITGA6, ITGB4, TNF
24positive regulation of transcription, DNA-dependentGO:0458938.4TNF, CIITA, IL5, IL4, TGFB1
25immune responseGO:0069558.4HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL5, IL4
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.2ITGA6, CIITA, IL4, TGFB1, TNF

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQB1
2integrin bindingGO:0051789.3DST, ITGA6, CTGF
3growth factor activityGO:0080838.6TGFB1, IL4, IL5, CTGF, CSF1
4cytokine activityGO:0051258.2CSF1, TNF, MIF, IL5, IL4

Products for genes affiliated with Ocular Cicatricial Pemphigoid

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Ocular Cicatricial Pemphigoid

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet