MCID: OCL020
MIFTS: 52

Ocular Cicatricial Pemphigoid malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ocular Cicatricial Pemphigoid

About this section
Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Ocular Cicatricial Pemphigoid:

Name: Ocular Cicatricial Pemphigoid 52 48 50 68
Pemphigoid, Benign Mucous Membrane 68
Cicatricial Pemphigoid, Ocular 48
Pemphigoid, Ocular Cicatricial 48
 
Mucous Membrane Pemphigoid 54
Mucosynechial Pemphigoid 54
Cicatricial Pemphigoid 54
Mucosal Pemphigoid 54

Characteristics:

Orphanet epidemiological data:

54
mucous membrane pemphigoid:
Inheritance: Not applicable; Age of onset: Adult; Age of death: normal life expectancy

HPO:

64
ocular cicatricial pemphigoid:
Inheritance: autosomal dominant inheritance

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

OMIM52 164185
Orphanet54 ORPHA46486
ICD10 via Orphanet31 L12.1

Summaries for Ocular Cicatricial Pemphigoid

About this section
NIH Rare Diseases:48 Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes. In the early stages, people with OCP generally experience chronic or relapsing conjunctivitis that is often characterized by tearing, irritation, burning, and/or mucus drainage. If left untreated, OCP can progress to severe conjunctiva scarring and vision loss. Involvement of other mucosal sites and the skin may also occur in OCP. The exact underlying cause is currently unknown. The treatment of OCP aims to slow disease progression and prevent complications. This usually involves long-term use of medications called immunomodulators which help regulate or normalize the immune system. Last updated: 6/10/2015

MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to keratoconjunctivitis and rheumatoid arthritis, and has symptoms including autoimmunity, abnormal blistering of the skin and inflammatory abnormality of the eye. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (Integrin Subunit Beta 4), and among its related pathways are Activation of TRKA receptors and IgA-Producing B Cells in the Intestine. Affiliated tissues include eye, skin and neutrophil, and related mouse phenotypes are Increased shRNA abundance and liver/biliary system.

Description from OMIM:52 164185

Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis30.1IL4, RNASE3
2rheumatoid arthritis26.7CD79A, CIITA, CSF1, HLA-DQB1, HLA-DRB1, IL4
3cicatricial pemphigoid10.9
4fibromatosis, gingival, 110.6CD36, SERPINH1, TGFB1
5pseudoainhum10.6NGF, RNASE3
6vibrio vulnificus infection10.5IL4, RNASE3, TGFB1
7chronic pulmonary heart disease10.5IL4, NGF, RNASE3
8churg-strauss syndrome10.5IL4, RNASE3, TGFB1
9blind hypotensive eye10.4IL4, RNASE3, TGFB1
10hypertensive encephalopathy10.4IL4, RNASE3, TGFB1
11epidermolysis bullosa, junctional, with pyloric stenosis10.4ITGA6, ITGB4
12lymphogranuloma venereum10.4CTGF, TGFB1
13chronic cystitis10.4CD79A, RNASE3
14esophageal atresia/tracheoesophageal fistula10.4ITGA6, ITGB4
15epidemic typhus10.4ACTA2, TGFB1, TGFBR2
16salt and pepper syndrome10.4CTGF, SERPINH1, TGFB1
17ectopia lentis, familial10.4ACTA2, TGFB1, TGFBR2
18fruit allergy10.3HLA-DQB1, HLA-DRB1
19granulomatous orchitis10.3CD36, CTGF, TGFB1
20familial bicuspid aortic valve10.3PRG2, RNASE3
21apple allergy10.3CD79A, IL4, RNASE3
22wolffian duct adenocarcinoma10.3HLA-DQB1, HLA-DRB1
23gait apraxia10.3CD79A, IL4, RNASE3
24peripheral t-cell lymphoma10.3HLA-DQB1, HLA-DRB1, IL4
25lipodermatosclerosis10.3HLA-DQB1, HLA-DRB1, IL4
26quinquaud's decalvans folliculitis10.3HLA-DQB1, HLA-DRB1
27parsonage turner syndrome10.3HLA-DQB1, HLA-DRB1, TGFB1
28multicentric castleman disease10.3HLA-DQB1, HLA-DRB1, IL4
29myopathy-growth delay-intellectual disability-hypospadias syndrome10.3HLA-DQB1, HLA-DRB1, TGFB1
30benign lymphoepithelial lesion of salivary gland10.3CD79A, IL4, NGF
31nonspecific interstitial pneumonia10.3CTGF, IL4, TGFB1
32crustacean allergy10.3CD79A, RNASE3, TGFB1
33vaginitis10.3CD79A, IL4, RNASE3
34geotrichosis10.3CD79A, IL4, RNASE3
35low compliance bladder10.3IL4, NTRK1, TGFB1
36sarcoid meningitis10.3CD79A, IL4, RNASE3
37biliary tract disease10.3CD79A, IL4, RNASE3
38blood group incompatibility10.3CD79A, IL4, TGFB1
39exophthalmos10.3CD79A, IL4, RNASE3
40mediastinum seminoma10.3CD79A, IL4, TGFBR2
41sarcomatoid mesothelioma10.2IL4, NGF, RNASE3
42juvenile dermatitis herpetiformis10.2CD79A, HLA-DQB1, IL4
43perianal skin paget's disease10.2CD79A, IL4, TGFB1
44thomsen and becker disease10.2IL4, PRG2, RNASE3
45cataract10.2
46pediatric systemic lupus erythematosus10.1HLA-DQB1, HLA-DRB1
47peanut allergy10.1CD79A, IL4, RNASE3, TGFB1
48diamond-blackfan anemia 310.1CD36, CTGF, SERPINH1, TGFB1
49uterine corpus dissecting leiomyoma10.1CD79A, IL4, RNASE3, TGFB1
50laryngeal tuberculosis10.1CD79A, IL4, RNASE3, TGFB1

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms & Phenotypes for Ocular Cicatricial Pemphigoid

About this section

Symptoms by clinical synopsis from OMIM:

164185

Clinical features from OMIM:

164185

Human phenotypes related to Ocular Cicatricial Pemphigoid:

 64 54 (show all 12)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 autoimmunity64 54 hallmark (90%) Very frequent (99-80%) HP:0002960
2 abnormal blistering of the skin64 54 hallmark (90%) Occasional (29-5%) HP:0008066
3 inflammatory abnormality of the eye64 hallmark (90%) HP:0100533
4 abnormality of reproductive system physiology64 typical (50%) HP:0000080
5 gingivitis64 54 typical (50%) Frequent (79-30%) HP:0000230
6 atypical scarring of skin64 54 typical (50%) Frequent (79-30%) HP:0000987
7 visual impairment64 occasional (7.5%) HP:0000505
8 opacification of the corneal stroma64 occasional (7.5%) HP:0007759
9 abnormality of the eye64 HP:0000478
10 blindness54 Occasional (29-5%)
11 corneal opacity54 Occasional (29-5%)
12 oral mucosal blisters54 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00327-A9.3CD36, CD79A, HLA-DQB1, IL4, SERPINH1

MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CD36, CSF1, HLA-DQB1, IL4, TGFB1, TGFBR2
2MP:00053778.8CSF1, CTGF, ITGA6, ITGB4, MIF, NTRK1
3MP:00053698.3ACTA2, CD36, CSF1, HLA-DQB1, NGF, NTRK1
4MP:00053907.9CD36, CIITA, CSF1, CTGF, IL4, SERPINH1
5MP:00053827.7CSF1, CTGF, IL4, ITGA6, ITGB4, SERPINH1
6MP:00107717.6CSF1, CTGF, IL4, ITGA6, ITGB4, NGF
7MP:00028737.5CD79A, CIITA, CTGF, HLA-DQB1, IL4, MIF
8MP:00053677.5CD36, CD79A, HLA-DQB1, IL4, ITGA6, ITGB4
9MP:00053797.4CD36, CIITA, CSF1, HLA-DQB1, IL4, ITGA6
10MP:00053886.9CSF1, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
11MP:00053916.9ACTA2, CD36, CSF1, CTGF, IL4, ITGA6
12MP:00053816.8CD36, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
13MP:00053846.6CD36, CD79A, CSF1, CTGF, HLA-DQB1, IL4
14MP:00107686.5CD36, CSF1, CTGF, HLA-DQB1, IL4, ITGA6
15MP:00053856.4ACTA2, CD36, CSF1, CTGF, HLA-DQB1, ITGA6
16MP:00053786.4CD36, CSF1, CTGF, HLA-DQB1, IL4, ITGA6
17MP:00053766.2CD36, CD79A, CIITA, CSF1, CTGF, HLA-DQB1
18MP:00036316.0CD36, CD79A, CSF1, HLA-DQB1, IL4, ITGA6
19MP:00053975.6CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4
20MP:00053875.5CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drugs for Ocular Cicatricial Pemphigoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mycophenolic acidapprovedPhase 393924280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
2
Mycophenolate mofetilapproved, investigationalPhase 3939128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
3Immunosuppressive AgentsPhase 312770
4Antibiotics, AntitubercularPhase 36972
5Anti-Bacterial AgentsPhase 310884
6
rituximabapprovedPhase 1, Phase 21654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
7
InfliximabapprovedPhase 1, Phase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
8
Riboflavinapproved, nutraceutical, vet_approvedPhase 1, Phase 216583-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
9
Folic Acidapproved, nutraceutical, vet_approvedPhase 1, Phase 2427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10Antirheumatic AgentsPhase 1, Phase 210627
11Trace ElementsPhase 1, Phase 25802
12Vitamin B ComplexPhase 1, Phase 24229
13VitaminsPhase 1, Phase 25095
14Pharmaceutical SolutionsPhase 1, Phase 27793
15Dermatologic AgentsPhase 1, Phase 25674
16MicronutrientsPhase 1, Phase 25802
17Photosensitizing AgentsPhase 1, Phase 2476
18Gastrointestinal AgentsPhase 1, Phase 28109
19FolateNutraceuticalPhase 1, Phase 24279
20Vitamin B9NutraceuticalPhase 1, Phase 24279
21Vitamin B2NutraceuticalPhase 1, Phase 2165
22ImmunoglobulinsPhase 16045
23AntibodiesPhase 16045
24Autoantibodies126

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid.Not yet recruitingNCT02993133Phase 3
2Clinical Trial Evaluating Rituximab in Ocular Cicatricial PemphigoidCompletedNCT00584935Phase 1, Phase 2
3Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter TrialRecruitingNCT02318485Phase 2
4Use of Cross-linked Donor Corneas as Carriers for the Boston KeratoprosthesisRecruitingNCT01582880Phase 1, Phase 2
5Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet TransplantationAvailableNCT02149732Phase 1, Phase 2
6Topical Infliximab in Autoimmune Eyes With KeratoprosthesisEnrolling by invitationNCT02126020Phase 1, Phase 2
7The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem CellsUnknown statusNCT02202642Phase 1
8Topical Infliximab for Sterile Corneal MeltNot yet recruitingNCT02987686Phase 1
9Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory ConditionsWithdrawnNCT02042027Phase 1
10Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort StudyCompletedNCT00116090
11Immune Responses to Antigens in Non-infectious Eye Inflammatory DiseasesEnrolling by invitationNCT00357071

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

About this section

MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

36
Eye, Skin, Neutrophil, Testes, T cells

Publications for Ocular Cicatricial Pemphigoid

About this section

Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid. (27275431)
2016
2
Update on ocular cicatricial pemphigoid and emerging treatments. (26708362)
2016
3
IgM ocular cicatricial pemphigoid: a unique insight into the immune system. (26632795)
2015
4
NGF Modulates trkANGFR/p75NTR in I+SMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP). (26569118)
2015
5
Characteristics of patients with ocular cicatricial pemphigoid referred to major tertiary hospital. (25863854)
2015
6
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
7
Neutrophil collagenase, gelatinase, and myeloperoxidase in tears of patients with stevens-johnson syndrome and ocular cicatricial pemphigoid. (23962653)
2014
8
Outcomes of cataract surgery in ocular cicatricial pemphigoid. (23941520)
2013
9
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
10
Coexistence of ocular cicatricial pemphigoid with Stevens Johnson syndrome. (23826544)
2013
11
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
12
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
13
The frequency of other autoimmune disorders in patients with ocular cicatricial pemphigoid. (21595864)
2012
14
Improvement in ocular cicatricial pemphigoid following treatment for porphyria cutanea tarda. (23118521)
2012
15
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
16
Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. (21279976)
2011
17
Ocular cicatricial pemphigoid: a review of clinical features, immunopathology, differential diagnosis, and current management. (21958173)
2011
18
Peripheral ulcerative keratitis after cataract surgery in a patient with ocular cicatricial pemphigoid. (21822128)
2011
19
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
20
Anterior lamellar excision and laissez-faire healing for aberrant lashes in ocular cicatricial pemphigoid. (19911023)
2010
21
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
22
Combination of rituximab and intravenous immunoglobulin for recalcitrant ocular cicatricial pemphigoid: a preliminary report. (20045562)
2010
23
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
24
T-helper 17 lymphocytes in ocular cicatricial pemphigoid. (19641634)
2009
25
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
26
Transscleral diode laser cyclophotocoagulation in a patient with ocular cicatricial pemphigoid. (19928727)
2009
27
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
28
Exacerbation of undiagnosed ocular cicatricial pemphigoid after repair of involutional entropion. (18356734)
2008
29
Ocular cicatricial pemphigoid. (18762085)
2008
30
Treatment of ocular cicatricial pemphigoid with the tumour necrosis factor alpha antagonist etanercept. (17225020)
2007
31
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
32
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (17179127)
2007
33
Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid. (17488321)
2007
34
In vivo confocal microscopy of ocular cicatricial pemphigoid. (16583645)
2006
35
Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. (16950250)
2006
36
Dapsone induced haemolytic anaemia in patients treated for ocular cicatricial pemphigoid. (16547343)
2006
37
Ocular cicatricial pemphigoid. (16954792)
2006
38
Ocular cicatricial pemphigoid: manifestations and management. (15967079)
2005
39
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
40
Blood group related antigens in ocular cicatricial pemphigoid. (15377543)
2004
41
Role of macrophage migration inhibitory factor in conjunctival pathology in ocular cicatricial pemphigoid. (15037585)
2004
42
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
43
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
44
Ocular cicatricial pemphigoid review. (15349045)
2004
45
Ocular cicatricial pemphigoid: pathogenesis, diagnosis and treatment. (15388075)
2004
46
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
47
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
48
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
49
Ocular cicatricial pemphigoid. (12568651)
2003
50
Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid. (12657600)
2003

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9NGF, NTRK1
29.8CD36, IL4, TGFB1
39.8IL4, TGFB1, TGFBR2
49.6CTGF, TGFB1, TGFBR2
59.4CSF1, HLA-DRB1, IL4, TGFB1
69.4CD36, CD79A, CSF1, IL4
79.3CSF1, HLA-DQB1, HLA-DRB1, TGFB1
89.2HLA-DQB1, HLA-DRB1, TGFB1, TGFBR2
9
Show member pathways
9.2ITGA6, ITGB4, TGFB1
108.9CIITA, HLA-DQB1, HLA-DRB1, TGFB1
118.8CSF1, IL4, ITGA6, ITGB4, NGF
128.6CD36, CSF1, HLA-DRB1, IL4, ITGA6
13
Show member pathways
8.6CTGF, IL4, NGF, TGFB1, TGFBR2, TNFRSF1B
14
Show member pathways
8.6CD79A, HLA-DQB1, HLA-DRB1, IL4, TNFRSF1B
15
Show member pathways
8.4ACTA2, ITGA6, ITGB4, NTRK1, TGFB1, TGFBR2
168.3CTGF, ITGA6, ITGB4, NGF, NTRK1, TGFB1
17
Show member pathways
8.2ACTA2, HLA-DQB1, HLA-DRB1, ITGA6, ITGB4, NTRK1
18
Show member pathways
7.9CIITA, HLA-DQB1, HLA-DRB1, IL4, PRG2, RNASE3
19
Show member pathways
7.9CIITA, HLA-DQB1, HLA-DRB1, IL4, ITGA6, TGFB1
20
Show member pathways
7.8ACTA2, CSF1, CTGF, IL4, NGF, NTRK1
21
Show member pathways
7.3CTGF, IL4, ITGA6, ITGB4, NGF, NTRK1
22
Show member pathways
7.1ACTA2, CSF1, CTGF, IL4, ITGA6, ITGB4
23
Show member pathways
7.0ACTA2, CD79A, CTGF, ITGA6, ITGB4, NGF
24
Show member pathways
6.6ACTA2, CD79A, CTGF, HLA-DQB1, HLA-DRB1, ITGA6
25
Show member pathways
6.3ACTA2, CSF1, CTGF, IL4, ITGA6, ITGB4

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:003066610.3CD36, HLA-DQB1, HLA-DRB1
2hemidesmosomeGO:003005610.3ITGA6, ITGB4
3membrane raftGO:00451219.6CD36, CD79A, SERPINH1, TGFBR2, TNFRSF1B
4external side of plasma membraneGO:00098979.3CD36, CD79A, IL4, ITGA6, TGFBR2
5extracellular spaceGO:00056159.0ACTA2, CD36, CSF1, CTGF, IL4, MIF
6cell surfaceGO:00099867.9CD36, CIITA, HLA-DRB1, ITGA6, ITGB4, MIF
7plasma membraneGO:00058866.1CD36, CD79A, CSF1, CTGF, HLA-DQB1, HLA-DRB1

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1common-partner SMAD protein phosphorylationGO:000718210.7TGFB1, TGFBR2
2positive regulation of mononuclear cell migrationGO:007167710.7IL4, TGFB1
3pathway-restricted SMAD protein phosphorylationGO:006038910.7TGFB1, TGFBR2
4response to cholesterolGO:007072310.6TGFB1, TGFBR2
5myeloid dendritic cell differentiationGO:004301110.5IL4, TGFB1, TGFBR2
6positive regulation of Ras protein signal transductionGO:004657910.4CSF1, NGF, NTRK1
7positive regulation of MHC class II biosynthetic processGO:004534810.3CIITA, IL4
8B cell differentiationGO:003018310.3CD79A, IL4, NTRK1
9amelogenesisGO:009718610.2ITGA6, ITGB4
10hemidesmosome assemblyGO:003158110.2ITGA6, ITGB4
11nail developmentGO:003587810.2ITGA6, ITGB4
12cellular response to growth factor stimulusGO:007136310.2NTRK1, TGFB1, TNFRSF1B
13positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.2CD36, IL4, MIF, TGFB1
14response to glucoseGO:000974910.1CTGF, TGFB1, TGFBR2
15negative regulation of gene expressionGO:001062910.0CD36, CTGF, MIF, TGFB1
16positive regulation of ERK1 and ERK2 cascadeGO:00703749.9CD36, CTGF, MIF, NTRK1
17interferon-gamma-mediated signaling pathwayGO:00603339.9CIITA, HLA-DQB1, HLA-DRB1
18positive regulation of cell proliferationGO:00082849.8CSF1, CTGF, IL4, TGFB1, TGFBR2
19response to organic cyclic compoundGO:00140709.8CTGF, IL4, TGFB1, TGFBR2
20integrin-mediated signaling pathwayGO:00072299.8CTGF, ITGA6, ITGB4
21positive regulation of gene expressionGO:00106289.8ACTA2, CSF1, CTGF, NGF, TGFB1
22regulation of cell proliferationGO:00421279.7MIF, TGFB1, TGFBR2, TNFRSF1B
23digestive tract developmentGO:00485659.7ITGA6, ITGB4, TGFB1, TGFBR2
24positive regulation of protein phosphorylationGO:00019349.7CTGF, IL4, MIF, NTRK1, TGFB1
25response to woundingGO:00096119.6CTGF, ITGB4, TGFB1
26inflammatory responseGO:00069549.3CIITA, CSF1, MIF, TGFB1, TNFRSF1B
27agingGO:00075688.9CIITA, CTGF, NTRK1, TGFB1, TGFBR2, TNFRSF1B
28immune responseGO:00069558.8CD36, CIITA, HLA-DQB1, IL4, PRG2, TNFRSF1B

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.1CSF1, IL4, MIF, TGFB1
2type I transforming growth factor beta receptor bindingGO:003471310.0TGFB1, TGFBR2
3insulin-like growth factor I bindingGO:00319949.8ITGA6, ITGB4
4neuregulin bindingGO:00381329.7ITGA6, ITGB4
5growth factor activityGO:00080839.6CSF1, CTGF, IL4, NGF, TGFB1

Sources for Ocular Cicatricial Pemphigoid

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet