MCID: OCL020
MIFTS: 44

Ocular Cicatricial Pemphigoid malady

Rare diseases category

Aliases & Classifications for Ocular Cicatricial Pemphigoid

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Aliases & Descriptions for Ocular Cicatricial Pemphigoid:

Name: Ocular Cicatricial Pemphigoid 42 44 61
Cicatricial Pemphigoid, Ocular 42
 
Pemphigoid, Ocular Cicatricial 42


Classifications:



Summaries for Ocular Cicatricial Pemphigoid

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MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as cicatricial pemphigoid, ocular, is related to cicatricial pemphigoid and conjunctivitis, and has symptoms including autosomal dominant inheritanceand abnormality of the eye. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are Cell junction organization and Alpha6-Beta4 Integrin Signaling Pathway. The compounds unicap and beclomethasone dipropionate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are normal and limbs/digits/tail.

Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1cicatricial pemphigoid32.3DST, ITGA6, ITGB4, CD79A
2conjunctivitis31.3RNASE3, CD79A
3bullous pemphigoid31.3ITGA6, DST
4pemphigus31.2DST, CD79A
5keratoconjunctivitis31.1RNASE3, IL5
6rheumatoid arthritis30.9HLA-DRB1, CIITA
7pemphigus vulgaris30.9HLA-DRB1, CIITA, DST
8arthritis29.1HLA-DRB1, TNF, TGFB1, CIITA, MIF, IL4
9cataract10.6
10entropion10.6
11collagenous colitis10.6RNASE3
12kindler syndrome10.6ITGB4
13strongyloidiasis10.5IL5
14giardiasis10.5CD79A
15amebiasis10.5CD79A
16paragonimiasis10.5IL5
17eosinophilic gastroenteritis10.5IL5
18eosinophilia-myalgia syndrome10.5IL5
19exanthem10.5CD79A
20cryptosporidiosis10.5CD79A
21epidermolysis bullosa with pyloric atresia10.5ITGA6, ITGB4
22leprosy10.5HLA-DRB1
23keratitis10.4
24bronchitis10.4RNASE3, CD79A
25aspergillosis10.4CD79A, CSF1
26blau syndrome10.4TNF
27henoch-schoenlein purpura10.4RNASE3, CD79A
28chronic eosinophilic pneumonia10.4IL5, RNASE3
29giant papillary conjunctivitis10.4RNASE3, IL5
30parasitic helminthiasis infectious disease10.4RNASE3, IL5
31onchocerciasis10.4RNASE3, IL5
32churg-strauss syndrome10.4RNASE3, IL5
33herpes gestationis10.4DST, RNASE3
34eosinophilic pneumonia10.4RNASE3, IL5
35gastroenteritis10.3CD79A
36epidermolysis bullosa simplex10.3DST, ITGB4
37membranous glomerulonephritis, antenatal10.3CD79A, CTGF
38periapical granuloma10.3IL4
39junctional epidermolysis bullosa10.3DST, ITGA6, ITGB4
40bullous skin disease10.3DST, IL5
41epidermolysis bullosa10.3ITGB4, ITGA6, DST
42immunoglobulin alpha deficiency10.3HLA-DQB1, CD79A
43kimura disease10.3IL5, PRG2, RNASE3
44bronchiectasis10.3RNASE3, CD79A
45hypereosinophilic syndrome10.3RNASE3, PRG2, IL5
46epidermolysis bullosa acquisita10.3CD79A, ITGB4, DST
47dermatitis herpetiformis10.3CD79A, HLA-DQB1
48porphyria cutanea tarda10.3
49wegener granulomatosis10.3
50neutropenia10.3

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms for Ocular Cicatricial Pemphigoid

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HPO human phenotypes related to Ocular Cicatricial Pemphigoid:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the eye HP:0000478

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

31
Eye, Testes, T cells

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

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MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5MIF, HLA-DQB1, CIITA, IL4, CD79A, CTGF
2MP:00053718.4TNF, DST, ITGA6, CSF1, CTGF, SERPINH1
3MP:00020068.2IL5, ITGA6, MIF, TGFB1, TNF
4MP:00053678.0IL4, HLA-DQB1, CD79A, TGFB1, DST, ITGB4
5MP:00053807.8TGFB1, SERPINH1, ITGA6, IL5, CTGF, TNF
6MP:00053857.6TNF, TGFB1, HLA-DQB1, CSF1, CTGF, ITGB4
7MP:00053827.6TNF, TGFB1, SERPINH1, ITGA6, ITGB4, CSF1
8MP:00053707.5HLA-DQB1, TGFB1, TNF, CSF1, IL5, IL4
9MP:00053797.5IL4, ITGA6, CIITA, TGFB1, HLA-DQB1, CSF1
10MP:00053917.4IL4, CTGF, ITGB4, CSF1, TGFB1, TNF
11MP:00107717.4IL4, TNF, TGFB1, DST, ITGA6, ITGB4
12MP:00053897.1IL5, IL4, DST, TNF, TGFB1, HLA-DQB1
13MP:00053867.1IL5, HLA-DQB1, TGFB1, DST, ITGB4, CSF1
14MP:00053846.8CSF1, TNF, TGFB1, MIF, ITGA6, ITGB4
15MP:00053816.8DST, IL5, CTGF, IL4, ITGB4, HLA-DQB1
16MP:00036316.7TNF, TGFB1, SERPINH1, DST, ITGA6, IL4
17MP:00107686.6IL4, HLA-DQB1, CSF1, TNF, TGFB1, SERPINH1
18MP:00053786.6HLA-DQB1, CSF1, CTGF, TNF, TGFB1, SERPINH1
19MP:00053886.3TGFB1, SERPINH1, PRG2, IL4, ITGB4, TNF
20MP:00053766.1CIITA, DST, IL4, MIF, ITGB4, CD79A
21MP:00053876.0PRG2, MIF, ITGA6, ITGB4, IL4, IL5
22MP:00053975.8IL5, CSF1, CD79A, IL4, ITGA6, MIF

Publications for Ocular Cicatricial Pemphigoid

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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
2
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
3
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
4
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
5
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
6
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
7
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
8
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
9
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
10
Ocular cicatricial pemphigoid. (18762085)
2008
11
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
12
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
13
Ocular cicatricial pemphigoid. (16954792)
2006
14
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
15
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
16
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
17
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
18
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
19
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
20
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
21
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
22
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
23
The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. (10946315)
2000
24
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
25
Linear IgA dermatosis mimicking ocular cicatricial pemphigoid. (10555732)
1999
26
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
27
Pure ocular cicatricial pemphigoid. A distinct immunopathologic subset of cicatricial pemphigoid. (9951490)
1999
28
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
29
Treatment of ocular cicatricial pemphigoid with intravenous gammaglobulin. (9689316)
1998
30
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
31
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
32
Conjunctival scarring after eyelid surgery as first sign of ocular cicatricial pemphigoid. (9076789)
1997
33
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
34
Conjunctival fibrosis in ocular cicatricial pemphigoid--the role of cytokines. (9268585)
1997
35
Progression of disease in ocular cicatricial pemphigoid. (8703876)
1996
36
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid. (8759268)
1996
37
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
38
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
39
Ocular cicatricial pemphigoid. A case report of monozygotic twins discordant for the disease. (7864752)
1995
40
Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. (9097741)
1995
41
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
42
Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid. (7800360)
1994
43
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
44
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
45
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
46
Ocular cicatricial pemphigoid and oesophageal carcinoma. (2203219)
1990
47
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
48
Ocular cicatricial pemphigoid with granular IgA and complement deposition. (3904684)
1985
49
Enigma of ocular cicatricial pemphigoid. A comparative study of clinical and immunological findings. (398602)
1979
50
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DST, ITGB4, ITGA6
2
Show member pathways
9.7ITGA6, ITGB4, DST
39.6IL4, IL5
49.4CIITA, IL4, CD79A
5
Show member pathways
9.4ITGB4, DST, SERPINH1, ITGA6
6
Show member pathways
Proteogylcan syndecan-mediated signaling events36
9.4ITGA6, ITGB4, TGFB1
79.4ITGA6, HLA-DRB1, HLA-DQB1
89.3IL4, TGFB1
99.3TNF, CSF1
10
Show member pathways
Immune response T cell receptor signaling pathway59
Immune response CD28 signaling59
Immune response ICOS pathway in T helper cell59
9.3HLA-DRB1, CD79A, HLA-DQB1
119.2ITGB4, ITGA6, IL4, CSF1
12
Show member pathways
9.2ITGA6, ITGB4, HLA-DQB1, HLA-DRB1
13
Show member pathways
9.0IL5, CIITA, HLA-DRB1, HLA-DQB1
149.0TGFB1, TNF
159.0TGFB1, IL4, IL5
16
Show member pathways
8.9ITGB4, PRG2, ITGA6, TGFB1
17
Show member pathways
8.9ITGB4, ITGA6, TGFB1, PRG2
18
Show member pathways
8.8ITGB4, TGFB1, SERPINH1, DST, ITGA6
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.8IL4, IL5, TNF
208.8TNF, IL5, IL4
218.7TNF, TGFB1, MIF
228.7TGFB1, CSF1, TNF
23
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
8.6TGFB1, ITGB4, ITGA6, TNF
24
Show member pathways
8.6ITGB4, ITGA6, TGFB1, TNF
25
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
8.5IL4, IL5, CD79A, TNF
26
Show member pathways
8.3TGFB1, TNF, ITGB4, CTGF, ITGA6
278.2IL4, TGFB1, TNF, MIF
288.2TGFB1, HLA-DQB1, TNF, HLA-DRB1
29
Show member pathways
8.0TNF, HLA-DQB1, IL4, CIITA, HLA-DRB1
30
Show member pathways
8.0TGFB1, ITGB4, CD79A, CTGF, HLA-DQB1, HLA-DRB1
31
Show member pathways
8.0CD79A, HLA-DRB1, TNF, HLA-DQB1, IL4
327.9CIITA, HLA-DQB1, HLA-DRB1, TNF, TGFB1
33
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.9IL4, TGFB1, TNF, CD79A, IL5
347.8HLA-DRB1, TNF, HLA-DQB1, TGFB1, CSF1
357.8ITGA6, IL4, CSF1, IL5, HLA-DRB1, TNF
36
Show member pathways
7.6IL5, IL4, TNF, CSF1, CTGF, TGFB1
37
Show member pathways
7.6CSF1, IL5, MIF, TGFB1, TNF, IL4
38
Show member pathways
7.5ITGA6, TGFB1, ITGB4, IL4, CTGF, IL5
397.4IL5, CSF1, HLA-DRB1, TNF, TGFB1, IL4
40
Show member pathways
7.1TGFB1, TNF, ITGA6, ITGB4, IL4, IL5
41
Show member pathways
6.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, IL5, IL4
42
Show member pathways
6.6TGFB1, ITGB4, PRG2, ITGA6, IL4, IL5
43
Show member pathways
6.3HLA-DQB1, HLA-DRB1, TNF, CIITA, TGFB1, RNASE3

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

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Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1unicap449.9CD79A, IL5, RNASE3
2beclomethasone dipropionate449.7CSF1, IL5, RNASE3
3sodium cromoglycate449.6CD79A, IL5, RNASE3
4salbutamol44 50 28 24 1113.6CD79A, RNASE3, IL5, CSF1
5nedocromil sodium449.4IL4, CSF1, IL5, RNASE3
6praziquantel44 1110.4RNASE3, IL4, IL5, CD79A
7ltc4449.4IL5, RNASE3, CSF1, PRG2
8anti-fungal449.4RNASE3, CD79A, CSF1, IL5
9glatiramer acetate44 1110.3IL5, HLA-DRB1, CIITA, IL4
10pranlukast44 28 1110.9IL5, TNF, IL4, RNASE3
11methylcellulose448.9IL4, TGFB1, CSF1, IL5
12prednisolone44 28 1110.8RNASE3, TNF, CSF1, CD79A, IL5
13thyroxine44 249.7CIITA, TGFB1, IL5, IL4, CD79A
14polyinosinic-polycytidylic acid448.7TNF, CIITA, IL4, IL5, CSF1
15n-formylmethionyl-leucylphenylalanine448.6IL5, RNASE3, TNF, CSF1
16budesonide44 50 1110.6RNASE3, IL4, CSF1, IL5, TNF
17fluticasone propionate44 50 60 1111.6TNF, RNASE3, IL4, IL5, CSF1
18ivig448.6TNF, IL5, CSF1, CD79A, IL4
19herbimycin a44 609.5IL5, MIF, TNF, IL4, ITGA6
20fmlp448.4TNF, CSF1, RNASE3, PRG2, IL5
21methacholine44 50 1110.3PRG2, IL4, CD79A, IL5, TGFB1, RNASE3
22n acetylcysteine448.3CTGF, CD79A, CSF1, IL4, RNASE3, TNF
23allergens448.3HLA-DRB1, CIITA, RNASE3, PRG2, IL4, CD79A
24gm-csf44 289.3IL5, TNF, TGFB1, CSF1, IL4
25il 10448.2TNF, TGFB1, IL4, IL5, CSF1
26h2o2448.2IL5, MIF, CTGF, TNF, RNASE3, CSF1
27carbamazepine44 50 1110.2TNF, IL4, IL5, CD79A
28paraffin448.1IL5, TGFB1, DST, MIF, IL4, CD79A
29methotrexate50 44 1110.1TNF, CD79A, IL5, ITGA6, TGFB1, HLA-DRB1
30nitric oxide44 24 1110.0RNASE3, PRG2, CTGF, MIF, ITGB4, SERPINH1
31cysteine448.0CIITA, CTGF, IL4, MIF, PRG2, CSF1
32lactate448.0TNF, RNASE3, MIF, CD79A, CTGF, TGFB1
33sb 20358044 609.0TGFB1, MIF, IL4, IL5, CTGF, TNF
34tacrolimus44 50 119.9IL5, CD79A, IL4, TGFB1, TNF
35ly294002447.9TGFB1, IL4, CSF1, TNF, IL5, CTGF
36arginine447.8CD79A, CSF1, IL5, IL4, RNASE3, PRG2
37actinomycin d447.7TGFB1, CIITA, PRG2, IL4, CSF1, TNF
38rantes447.5IL4, TNF, TGFB1, CIITA, RNASE3, CSF1
39thymidine44 248.5CIITA, IL5, TNF, TGFB1, MIF, IL4
40indomethacin44 28 60 1110.4TGFB1, TNF, PRG2, IL4, IL5, CSF1
41serine447.4ITGB4, TGFB1, CTGF, TNF, CIITA, CSF1
42cycloheximide447.4DST, CSF1, IL4, TGFB1, TNF, IL5
43cyclosporin a44 28 609.3CTGF, TGFB1, TNF, SERPINH1, CIITA, CD79A
44oligonucleotide447.3PRG2, ITGA6, RNASE3, DST, SERPINH1, CIITA
45histamine44 28 249.2IL5, IL4, CD79A, CSF1, TNF, TGFB1
46pge2447.0TGFB1, CD79A, CSF1, IL5, IL4, MIF
47dexamethasone44 50 28 119.9TGFB1, TNF, CSF1, CIITA, RNASE3, MIF
48retinoic acid44 247.7ITGA6, TGFB1, IL5, TNF, ITGB4, RNASE3
49vegf446.7TNF, CD79A, CSF1, CTGF, IL5, IL4
50tyrosine446.6CTGF, CSF1, HLA-DRB1, CIITA, IL4, SERPINH1

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:00300569.8DST, ITGA6, ITGB4
2basal plasma membraneGO:00099259.8ITGB4, ITGA6, DST
3MHC class II protein complexGO:00426139.6HLA-DRB1, HLA-DQB1
4basement membraneGO:00056049.4ITGB4, ITGA6, DST
5cell surfaceGO:00099868.4TNF, TGFB1, CIITA, MIF, ITGB4
6external side of plasma membraneGO:00098978.3HLA-DRB1, TNF, ITGA6, IL4, CD79A
7extracellular regionGO:00055767.4TNF, TGFB1, RNASE3, PRG2, MIF, IL5
8extracellular spaceGO:00056157.3CTGF, CSF1, IL5, IL4, MIF, SERPINH1
9plasma membraneGO:00058866.7HLA-DQB1, HLA-DRB1, TNF, TGFB1, ITGA6, ITGB4

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell motilityGO:004887010.1DST, ITGB4
2cell-matrix adhesionGO:000716010.1ITGA6, ITGB4, CTGF
3positive regulation of phosphorylationGO:004232710.1MIF, ITGA6
4hemidesmosome assemblyGO:003158110.1DST, ITGA6, ITGB4
5positive regulation of MHC class II biosynthetic processGO:004534810.1CIITA, IL4
6filopodium assemblyGO:004684710.0ITGA6, ITGB4
7immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DRB1, HLA-DQB1
8humoral immune response mediated by circulating immunoglobulinGO:00024559.9HLA-DRB1, HLA-DQB1
9integrin-mediated signaling pathwayGO:00072299.8ITGB4, ITGA6, DST, CTGF
10positive regulation of cellular protein metabolic processGO:00322709.8CSF1, TGFB1
11interferon-gamma-mediated signaling pathwayGO:00603339.7HLA-DRB1, CIITA, HLA-DQB1
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:020003439.7TNF, MIF
13positive regulation of B cell proliferationGO:00308909.7IL5, IL4, MIF
14positive regulation of podosome assemblyGO:00718039.7TNF, IL5
15positive regulation of collagen biosynthetic processGO:00329679.5CTGF, TGFB1
16positive regulation of osteoclast differentiationGO:00456729.5TNF, CSF1
17positive regulation of gene expressionGO:00106289.5TGFB1, CSF1, CTGF
18positive regulation of chemokine biosynthetic processGO:00450809.5TNF, IL4
19negative regulation of gene expressionGO:00106299.4TNF, MIF, CTGF
20cytokine-mediated signaling pathwayGO:00192219.4HLA-DQB1, IL5, CIITA, HLA-DRB1
21response to woundingGO:00096119.4CTGF, TGFB1, DST, ITGB4
22positive regulation of ERK1 and ERK2 cascadeGO:00703749.4TNF, CTGF, MIF
23positive regulation of cytokine secretionGO:00507159.4MIF, TNF
24positive regulation of protein complex assemblyGO:00313349.3TGFB1, TNF
25cellular response to organic cyclic compoundGO:00714079.2TNF, TGFB1, ITGA6
26positive regulation of MAP kinase activityGO:00434069.1MIF, TNF, TGFB1
27positive regulation of peptidyl-serine phosphorylationGO:00331389.1MIF, TGFB1, TNF
28protein import into nucleus, translocationGO:00000609.1TGFB1, TNF
29positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1TNF, IL5, IL4
30osteoclast differentiationGO:00303169.0TNF, CSF1
31positive regulation of protein phosphorylationGO:00019349.0TGFB1, CTGF, TNF
32negative regulation of transcription, DNA-templatedGO:00458928.5TNF, CIITA, IL4, TGFB1
33immune responseGO:00069558.4HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL4, IL5
34extracellular matrix organizationGO:00301988.4SERPINH1, ITGB4, TNF, TGFB1, ITGA6, DST
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.4TNF, IL4, CIITA, TGFB1, ITGA6
36positive regulation of transcription, DNA-templatedGO:00458938.3IL5, IL4, TGFB1, TNF, CIITA
37inflammatory responseGO:00069548.3TNF, TGFB1, CIITA, MIF, IL5, CSF1

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.5DST, ITGA6, CTGF
2MHC class II receptor activityGO:00323959.3HLA-DRB1, HLA-DQB1
3growth factor activityGO:00080838.5CTGF, CSF1, IL5, IL4, TGFB1
4cytokine activityGO:00051258.2TNF, MIF, IL4, IL5, CSF1
5protein bindingGO:00055156.6TGFB1, CIITA, DST, MIF, ITGA6, ITGB4

Sources for Ocular Cicatricial Pemphigoid

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet