MCID: OCL020
MIFTS: 39

Ocular Cicatricial Pemphigoid malady

Rare diseases category

Aliases & Classifications for Ocular Cicatricial Pemphigoid

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Sources:
45NIH Rare Diseases, 47Novoseek, 65UMLS
See all sources

Aliases & Descriptions for Ocular Cicatricial Pemphigoid:

Name: Ocular Cicatricial Pemphigoid 45 47 65
Cicatricial Pemphigoid, Ocular 45
 
Pemphigoid, Ocular Cicatricial 45


Classifications:



Summaries for Ocular Cicatricial Pemphigoid

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NIH Rare Diseases:45 Ocular cicatricial pemphigoid (ocp) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes. in the early stages, people with ocp generally experience chronic or relapsing conjunctivitis that is often characterized by tearing, irritation, burning, and/or mucus drainage. if left untreated, ocp can progress to severe conjunctiva scarring and vision loss. involvement of other mucosal sites and the skin may also occur in ocp. the exact underlying cause is currently unknown. the treatment of ocp aims to slow disease progression and prevent complications. this usually involves long-term use of medications called immunomodulators which help regulate or normalize the immune system. last updated: 6/10/2015

MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as cicatricial pemphigoid, ocular, is related to conjunctivitis and rheumatoid arthritis, and has symptoms including autoimmunity, abnormal blistering of the skin and inflammatory abnormality of the eye. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (Integrin, Beta 4), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and LDL Oxidation in Atherogenesis. Affiliated tissues include eye, skin and neutrophil, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis30.9CD79A, IL4, RNASE3
2rheumatoid arthritis29.3CD79A, CIITA, CSF1, HLA-DQB1, HLA-DRB1, IL4
3cicatricial pemphigoid11.4
4cataract10.7
5entropion10.6
6pemphigus10.5
7bullous pemphigoid10.5
8keratitis10.5
9pemphigus vulgaris10.5
10porphyria cutanea tarda10.3
11autoimmune disease 110.3
12autoimmune disease 410.3
13wegener granulomatosis10.3
14autoimmune disease 210.3
15autoimmune disease 310.3
16arthritis10.3
17neutropenia10.3
18skin conditions10.3
19skin disease10.3
20gamma chain deficiency10.3
21sjogren's syndrome10.3
22trachoma10.3
23mucoepidermoid carcinoma10.3
24spiradenoma10.3
25bullous skin disease10.3
26chronic conjunctivitis10.3
27conjunctival disease10.3
28corneal ulcer10.3
29eye disease10.3
30globe disease10.3
31hypersensitivity reaction type ii disease10.3
32keratoconjunctivitis10.3
33porphyria10.3
34skin tag10.3
35vesiculobullous skin disease10.3
36atopic keratoconjunctivitis10.3
37mucous membrane pemphigoid10.3
38linear lichen planus10.3CD79A, ITGB4
39early myoclonic encephalopathy10.3CD79A, IL4
4046 xx gonadal dysgenesis10.2CD36, CD79A
41alternating exotropia10.2IL4, RNASE3
42fibromatosis, gingival, 110.2CD36, SERPINH1, TGFB1
43epidermolysis bullosa, junctional, with pyloric stenosis10.2ITGA6, ITGB4
44byssinosis10.2CD79A, ITGB4, SERPINH1
45miliaria rubra10.2CTGF, TGFB1
46trench fever10.2IL4, RNASE3
47basal ganglia cerebrovascular disease10.2CD79A, TGFB1
48tucker syndrome10.2HLA-DQB1, HLA-DRB1
49testicular monophasic choriocarcinoma10.2HLA-DQB1, HLA-DRB1
50paraphilia disorder10.2CD79A, IL4, TGFB1

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms for Ocular Cicatricial Pemphigoid

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HPO human phenotypes related to Ocular Cicatricial Pemphigoid:

(show all 10)
id Description Frequency HPO Source Accession
1 autoimmunity hallmark (90%) HP:0002960
2 abnormal blistering of the skin hallmark (90%) HP:0008066
3 inflammatory abnormality of the eye hallmark (90%) HP:0100533
4 abnormality of reproductive system physiology typical (50%) HP:0000080
5 gingivitis typical (50%) HP:0000230
6 atypical scarring of skin typical (50%) HP:0000987
7 visual impairment occasional (7.5%) HP:0000505
8 opacification of the corneal stroma occasional (7.5%) HP:0007759
9 autosomal dominant inheritance HP:0000006
10 abnormality of the eye HP:0000478

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drugs for Ocular Cicatricial Pemphigoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 1, Phase 21514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2
InfliximabapprovedPhase 1, Phase 2327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
3
Riboflavinapproved, nutraceuticalPhase 1, Phase 213883-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
Hyre
Lactobene
 
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavin
Riboflavin phosphate sodium dihydrate
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
e101
4
Folic Acidapproved, nutraceuticalPhase 1, Phase 2285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
5Vitamin B ComplexPhase 1, Phase 22775
6Vitamin B9NutraceuticalPhase 1, Phase 22851
7Vitamin B2NutraceuticalPhase 1, Phase 2138
8FolateNutraceuticalPhase 1, Phase 22851
9Rho(D) Immune GlobulinPhase 1198
10CyclosporinsPhase 1849
11Immunoglobulins, IntravenousPhase 1203

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Trial Evaluating Rituximab in Ocular Cicatricial PemphigoidCompletedNCT00584935Phase 1, Phase 2
2Use of Cross-linked Donor Corneas as Carriers for the Boston KeratoprosthesisRecruitingNCT01582880Phase 1, Phase 2
3Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet TransplantationAvailableNCT02149732Phase 1, Phase 2
4Topical Infliximab in Autoimmune Eyes With KeratoprosthesisEnrolling by invitationNCT02126020Phase 1, Phase 2
5Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter TrialNot yet recruitingNCT02318485Phase 2
6Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory ConditionsRecruitingNCT02042027Phase 1
7The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem CellsRecruitingNCT02202642Phase 1
8Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort StudyCompletedNCT00116090
9Immune Responses to Antigens in Non-infectious Eye Inflammatory DiseasesEnrolling by invitationNCT00357071

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

33
Eye, Skin, Neutrophil, Testes, T cells

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

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MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CD36, CSF1, HLA-DQB1, IL4, TGFB1, TGFBR2
2MP:00053678.2CD36, CD79A, HLA-DQB1, IL4, ITGA6, ITGB4
3MP:00028738.2CD79A, CIITA, CTGF, HLA-DQB1, IL4, MIF
4MP:00053827.9CSF1, CTGF, IL4, ITGA6, ITGB4, SERPINH1
5MP:00053917.7CD36, CSF1, CTGF, IL4, ITGA6, ITGB4
6MP:00053817.5CD36, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
7MP:00053857.3CD36, CSF1, CTGF, HLA-DQB1, ITGA6, ITGB4
8MP:00053797.0CD36, CIITA, CSF1, HLA-DQB1, IL4, ITGA6
9MP:00036316.9CD36, CD79A, CSF1, HLA-DQB1, IL4, ITGA6
10MP:00053846.8CD36, CD79A, CSF1, CTGF, HLA-DQB1, IL4
11MP:00053886.7CSF1, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
12MP:00053766.7CD36, CD79A, CIITA, CSF1, CTGF, HLA-DQB1
13MP:00053975.6CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4
14MP:00053875.6CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4

Publications for Ocular Cicatricial Pemphigoid

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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
NGF Modulates trkANGFR/p75NTR in I+SMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP). (26569118)
2015
2
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
3
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
4
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
5
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
6
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
7
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
8
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
9
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
10
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
11
Ocular cicatricial pemphigoid. (18762085)
2008
12
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
13
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
14
Ocular cicatricial pemphigoid. (16954792)
2006
15
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
16
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
17
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
18
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
19
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
20
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
21
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
22
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
23
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
24
The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. (10946315)
2000
25
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
26
Linear IgA dermatosis mimicking ocular cicatricial pemphigoid. (10555732)
1999
27
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
28
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
29
Treatment of ocular cicatricial pemphigoid with intravenous gammaglobulin. (9689316)
1998
30
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
31
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
32
Conjunctival scarring after eyelid surgery as first sign of ocular cicatricial pemphigoid. (9076789)
1997
33
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
34
Conjunctival fibrosis in ocular cicatricial pemphigoid--the role of cytokines. (9268585)
1997
35
Progression of disease in ocular cicatricial pemphigoid. (8703876)
1996
36
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid. (8759268)
1996
37
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
38
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
39
Ocular cicatricial pemphigoid. A case report of monozygotic twins discordant for the disease. (7864752)
1995
40
Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. (9097741)
1995
41
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
42
Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid. (7800360)
1994
43
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
44
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
45
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
46
Ocular cicatricial pemphigoid and oesophageal carcinoma. (2203219)
1990
47
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
48
Ocular cicatricial pemphigoid with granular IgA and complement deposition. (3904684)
1985
49
Enigma of ocular cicatricial pemphigoid. A comparative study of clinical and immunological findings. (398602)
1979
50
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL4, TGFB1
29.9CD36, CSF1
39.4IL4, TGFB1, TGFBR2
4
Show member pathways
9.4IL4, TGFB1, TGFBR2
59.3CTGF, TGFB1, TGFBR2
69.3CSF1, HLA-DRB1, IL4, TGFB1
79.2IL4, MIF, PRG2, TGFB1
8
Show member pathways
9.2ITGA6, ITGB4, TGFB1
99.1CSF1, HLA-DQB1, HLA-DRB1, TGFB1
108.9HLA-DQB1, HLA-DRB1, TGFB1, TGFBR2
118.8CIITA, HLA-DQB1, HLA-DRB1, TGFB1
128.5CD36, CSF1, HLA-DRB1, IL4, ITGA6
13
Show member pathways
8.0CD79A, CTGF, ITGA6, ITGB4, PRG2, TGFB1
14
Show member pathways
7.7CIITA, HLA-DQB1, HLA-DRB1, IL4, ITGA6, TGFB1
15
Show member pathways
7.6CIITA, HLA-DQB1, HLA-DRB1, IL4, PRG2, RNASE3

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.3HLA-DQB1, HLA-DRB1
2endocytic vesicle membraneGO:003066610.0CD36, HLA-DQB1, HLA-DRB1
3hemidesmosomeGO:003005610.0ITGA6, ITGB4
4membrane raftGO:00451218.8CD36, CD79A, SERPINH1, TGFBR2
5external side of plasma membraneGO:00098978.4CD36, CD79A, HLA-DRB1, IL4, ITGA6, TGFBR2
6extracellular spaceGO:00056158.1CD36, CSF1, CTGF, IL4, MIF, RNASE3
7cell surfaceGO:00099867.0CD36, CIITA, HLA-DRB1, ITGA6, ITGB4, MIF
8plasma membraneGO:00058866.6CD36, CD79A, CSF1, CTGF, HLA-DQB1, HLA-DRB1

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell activationGO:005086810.6IL4, TGFB1
2response to fatty acidGO:007054210.4CD36, CTGF
3common-partner SMAD protein phosphorylationGO:000718210.4TGFB1, TGFBR2
4antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.4HLA-DQB1, HLA-DRB1
5positive regulation of macrophage derived foam cell differentiationGO:001074410.4CD36, CSF1
6immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.4HLA-DQB1, HLA-DRB1
7positive regulation of cellular protein metabolic processGO:003227010.3CSF1, TGFB1
8humoral immune response mediated by circulating immunoglobulinGO:000245510.3HLA-DQB1, HLA-DRB1
9pathway-restricted SMAD protein phosphorylationGO:006038910.3TGFB1, TGFBR2
10response to cholesterolGO:007072310.2TGFB1, TGFBR2
11positive regulation of MHC class II biosynthetic processGO:004534810.2CIITA, IL4
12response to woundingGO:000961110.2CTGF, ITGB4, TGFB1
13amelogenesisGO:009718610.1ITGA6, ITGB4
14nail developmentGO:003587810.1ITGA6, ITGB4
15renal system developmentGO:007200110.1ITGA6, ITGB4
16filopodium assemblyGO:004684710.0ITGA6, ITGB4
17hemidesmosome assemblyGO:00315819.9ITGA6, ITGB4
18response to glucoseGO:00097499.8CTGF, TGFB1, TGFBR2
19positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.8CD36, IL4, MIF, TGFB1
20positive regulation of protein phosphorylationGO:00019349.8CTGF, IL4, MIF, TGFB1
21myeloid dendritic cell differentiationGO:00430119.7IL4, TGFB1, TGFBR2
22negative regulation of gene expressionGO:00106299.7CD36, CTGF, MIF, TGFB1
23interferon-gamma-mediated signaling pathwayGO:00603339.7CIITA, HLA-DQB1, HLA-DRB1
24response to organic cyclic compoundGO:00140709.5CTGF, IL4, TGFB1, TGFBR2
25inflammatory responseGO:00069549.4CIITA, CSF1, MIF, TGFB1
26cell-matrix adhesionGO:00071609.2CTGF, ITGA6, ITGB4
27positive regulation of cell proliferationGO:00082849.0CSF1, CTGF, IL4, TGFB1, TGFBR2
28extracellular matrix organizationGO:00301988.9ITGA6, ITGB4, SERPINH1, TGFB1
29integrin-mediated signaling pathwayGO:00072298.8CTGF, ITGA6, ITGB4
30digestive tract developmentGO:00485658.6ITGA6, ITGB4, TGFB1, TGFBR2
31immune responseGO:00069558.6CIITA, HLA-DQB1, HLA-DRB1, IL4, PRG2

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:003239510.2HLA-DQB1, HLA-DRB1
2type I transforming growth factor beta receptor bindingGO:003471310.1TGFB1, TGFBR2
3type III transforming growth factor beta receptor bindingGO:003471410.1TGFB1, TGFBR2
4transforming growth factor beta bindingGO:005043110.0CD36, TGFBR2
5cytokine activityGO:00051259.4CSF1, IL4, MIF, TGFB1
6growth factor activityGO:00080839.3CSF1, CTGF, IL4, TGFB1

Sources for Ocular Cicatricial Pemphigoid

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet