MCID: OCL020
MIFTS: 49

Ocular Cicatricial Pemphigoid malady

Rare diseases category

Summaries for Ocular Cicatricial Pemphigoid

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34MalaCards
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MalaCards: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to cicatricial pemphigoid and conjunctivitis. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are Cell junction organization and Alpha6-Beta4 Integrin Signaling Pathway. The compounds unicap and beclomethasone dipropionate have been mentioned in the context of this disorder. Affiliated tissues include testes and t cells, and related mouse phenotypes are normal and limbs/digits/tail.

Aliases & Classifications for Ocular Cicatricial Pemphigoid

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44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

ocular cicatricial pemphigoid 44 46 63
pemphigoid, benign mucous membrane 63
pemphigoid, ocular cicatricial 44
cicatricial pemphigoid, ocular 44


Related Diseases for Ocular Cicatricial Pemphigoid

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18GeneCards, 19GeneDecks
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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1cicatricial pemphigoid32.1DST, ITGA6, ITGB4, CD79A
2conjunctivitis30.8CD79A, RNASE3
3bullous pemphigoid30.8ITGA6, DST
4pemphigus30.8CD79A, DST
5pemphigus vulgaris30.7CIITA, DST, HLA-DRB1
6keratoconjunctivitis30.6RNASE3, IL5
7rheumatoid arthritis30.5HLA-DRB1, CIITA
8arthritis30.1CIITA, MIF, HLA-DRB1, TNF, TGFB1, CTGF
9stevens-johnson syndrome10.7
10cataract10.6
11entropion10.6
12keratitis10.4
13mucoepidermoid carcinoma10.3
14porphyria cutanea tarda10.3
15sjogren's syndrome10.3
16trachoma10.3
17chronic conjunctivitis10.3
18corneal ulcer10.3
19glaucoma10.3
20neutropenia10.3
21porphyria10.3
22atopic keratoconjunctivitis10.3
23collagenous colitis10.1RNASE3
24kindler syndrome10.1ITGB4
25strongyloidiasis10.1IL5
26giardiasis10.1CD79A
27paragonimiasis10.1IL5
28amebiasis10.1CD79A
29eosinophilic gastroenteritis10.1IL5
30eosinophilia-myalgia syndrome10.1IL5
31epidermolysis bullosa simplex with pyloric atresia10.1ITGA6, ITGB4
32exanthem10.1CD79A
33cryptosporidiosis10.1CD79A
34epidermolysis bullosa with pyloric atresia10.1ITGB4, ITGA6
35leprosy10.1HLA-DRB1
36bronchitis10.1RNASE3, CD79A
37aspergillosis10.1CD79A, CSF1
38immunoglobulin a vasculitis10.1RNASE3, CD79A
39blau syndrome10.1TNF
40chronic eosinophilic pneumonia10.1RNASE3, IL5
41giant papillary conjunctivitis10.1IL5, RNASE3
42helminthiasis10.1IL5, RNASE3
43onchocerciasis10.1IL5, RNASE3
44churg-strauss syndrome10.1IL5, RNASE3
45herpes gestationis10.1RNASE3, DST
46eosinophilic pneumonia10.1IL5, RNASE3
47gastroenteritis10.1CD79A
48epidermolysis bullosa simplex10.1DST, ITGB4
49membranous glomerulonephritis10.1CD79A, CTGF
50periapical granuloma10.1IL4

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms for Ocular Cicatricial Pemphigoid

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Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ocular Cicatricial Pemphigoid

Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

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Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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34MalaCards
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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

34
Testes, T cells

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

38 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CTGF, CD79A, IL4, MIF, CIITA, HLA-DQB1
2MP:00053718.4TNF, SERPINH1, DST, ITGA6, CSF1, CTGF
3MP:00020068.2TNF, TGFB1, MIF, ITGA6, IL5
4MP:00053678.0HLA-DQB1, TGFB1, DST, ITGA6, ITGB4, IL4
5MP:00053807.8TNF, TGFB1, SERPINH1, ITGA6, IL5, CTGF
6MP:00053857.6HLA-DQB1, TNF, TGFB1, SERPINH1, ITGA6, ITGB4
7MP:00053827.6TNF, TGFB1, SERPINH1, ITGA6, ITGB4, IL4
8MP:00053707.5HLA-DQB1, TNF, TGFB1, IL4, IL5, CSF1
9MP:00053797.5HLA-DQB1, TNF, TGFB1, CIITA, ITGA6, IL4
10MP:00053917.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
11MP:00107717.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
12MP:00053897.1HLA-DQB1, TNF, TGFB1, DST, IL4, IL5
13MP:00053867.1HLA-DQB1, TNF, TGFB1, DST, ITGB4, IL5
14MP:00053846.8HLA-DQB1, TNF, TGFB1, MIF, ITGA6, ITGB4
15MP:00053816.8SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
16MP:00036316.7SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
17MP:00107686.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
18MP:00053786.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
19MP:00053886.3CTGF, HLA-DQB1, TNF, TGFB1, SERPINH1, PRG2
20MP:00053766.1DST, CIITA, TGFB1, TNF, HLA-DQB1, MIF
21MP:00053876.0PRG2, CIITA, TGFB1, TNF, HLA-DQB1, MIF
22MP:00053975.8DST, CIITA, TGFB1, TNF, HLA-DQB1, PRG2

Publications for Ocular Cicatricial Pemphigoid

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53PubMed
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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
Neutrophil collagenase, gelatinase, and myeloperoxidase in tears of patients with stevens-johnson syndrome and ocular cicatricial pemphigoid. (23962653)
2014
2
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
3
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
4
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
5
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
6
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
7
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
8
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
9
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
10
Ocular cicatricial pemphigoid. (18762085)
2008
11
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
12
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
13
Ocular cicatricial pemphigoid. (16954792)
2006
14
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
15
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
16
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
17
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
18
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
19
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
20
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
21
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
22
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
23
The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. (10946315)
2000
24
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
25
Linear IgA dermatosis mimicking ocular cicatricial pemphigoid. (10555732)
1999
26
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
27
Pure ocular cicatricial pemphigoid. A distinct immunopathologic subset of cicatricial pemphigoid. (9951490)
1999
28
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
29
Treatment of ocular cicatricial pemphigoid with intravenous gammaglobulin. (9689316)
1998
30
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
31
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
32
Conjunctival scarring after eyelid surgery as first sign of ocular cicatricial pemphigoid. (9076789)
1997
33
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
34
Conjunctival fibrosis in ocular cicatricial pemphigoid--the role of cytokines. (9268585)
1997
35
Progression of disease in ocular cicatricial pemphigoid. (8703876)
1996
36
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid. (8759268)
1996
37
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
38
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
39
Ocular cicatricial pemphigoid. A case report of monozygotic twins discordant for the disease. (7864752)
1995
40
Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. (9097741)
1995
41
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
42
Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid. (7800360)
1994
43
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
44
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
45
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
46
Ocular cicatricial pemphigoid occurring as a sequela of Stevens-Johnson syndrome. (1880886)
1991
47
Ocular cicatricial pemphigoid and oesophageal carcinoma. (2203219)
1990
48
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
49
Ocular cicatricial pemphigoid with granular IgA and complement deposition. (3904684)
1985
50
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Cicatricial Pemphigoid

Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 5Cell Signaling Technology, 31KEGG, 55R&D Systems, 61Thomson Reuters
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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DST, ITGB4, ITGA6
2
Show member pathways
9.7ITGA6, ITGB4, DST
39.6IL4, IL5
49.4CIITA, IL4, CD79A
5
Show member pathways
9.4ITGB4, DST, SERPINH1, ITGA6
6
Show member pathways
Proteogylcan syndecan-mediated signaling events39
9.4ITGA6, ITGB4, TGFB1
79.4ITGA6, HLA-DRB1, HLA-DQB1
89.3IL4, TGFB1
99.3TNF, CSF1
10
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.3HLA-DRB1, CD79A, HLA-DQB1
119.2ITGB4, ITGA6, IL4, CSF1
12
Show member pathways
9.2ITGA6, ITGB4, HLA-DQB1, HLA-DRB1
13
Show member pathways
9.0IL5, CIITA, HLA-DRB1, HLA-DQB1
149.0TGFB1, TNF
159.0TGFB1, IL4, IL5
16
Show member pathways
8.9ITGB4, PRG2, ITGA6, TGFB1
17
Show member pathways
8.9ITGB4, ITGA6, TGFB1, PRG2
18
Show member pathways
8.8ITGB4, TGFB1, SERPINH1, DST, ITGA6
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.8IL4, IL5, TNF
208.8TNF, IL5, IL4
218.7TNF, TGFB1, MIF
228.7TGFB1, CSF1, TNF
23
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
8.6TGFB1, ITGB4, ITGA6, TNF
24
Show member pathways
8.6ITGB4, ITGA6, TGFB1, TNF
25
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.5IL4, IL5, CD79A, TNF
26
Show member pathways
8.3TGFB1, TNF, ITGB4, CTGF, ITGA6
278.2IL4, TGFB1, TNF, MIF
288.2TGFB1, HLA-DQB1, TNF, HLA-DRB1
29
Show member pathways
8.0TNF, HLA-DQB1, IL4, CIITA, HLA-DRB1
30
Show member pathways
8.0TGFB1, ITGB4, CD79A, CTGF, HLA-DQB1, HLA-DRB1
31
Show member pathways
8.0CD79A, HLA-DRB1, TNF, HLA-DQB1, IL4
327.9CIITA, HLA-DQB1, HLA-DRB1, TNF, TGFB1
33
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
7.9IL4, TGFB1, TNF, CD79A, IL5
347.8HLA-DRB1, TNF, HLA-DQB1, TGFB1, CSF1
357.8ITGA6, IL4, CSF1, IL5, HLA-DRB1, TNF
36
Show member pathways
7.6IL5, IL4, TNF, CSF1, CTGF, TGFB1
37
Show member pathways
7.6CSF1, IL5, MIF, TGFB1, TNF, IL4
38
Show member pathways
7.5ITGA6, TGFB1, ITGB4, IL4, CTGF, IL5
397.4IL5, CSF1, HLA-DRB1, TNF, TGFB1, IL4
40
Show member pathways
7.1TGFB1, TNF, ITGA6, ITGB4, IL4, IL5
41
Show member pathways
6.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, IL5, IL4
42
Show member pathways
6.6TGFB1, ITGB4, PRG2, ITGA6, IL4, IL5
43
Show member pathways
6.3HLA-DQB1, HLA-DRB1, TNF, CIITA, TGFB1, RNASE3

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1unicap469.9CD79A, IL5, RNASE3
2beclomethasone dipropionate469.7CSF1, IL5, RNASE3
3sodium cromoglycate469.6CD79A, IL5, RNASE3
4salbutamol46 52 30 25 1213.6CD79A, RNASE3, IL5, CSF1
5nedocromil sodium469.4IL4, CSF1, IL5, RNASE3
6praziquantel46 1210.4RNASE3, IL4, IL5, CD79A
7ltc4469.4IL5, RNASE3, CSF1, PRG2
8anti-fungal469.4RNASE3, CD79A, CSF1, IL5
9glatiramer acetate46 1210.3IL5, HLA-DRB1, CIITA, IL4
10pranlukast46 30 1210.9IL5, TNF, IL4, RNASE3
11methylcellulose468.9IL4, TGFB1, CSF1, IL5
12prednisolone46 30 1210.8RNASE3, TNF, CSF1, CD79A, IL5
13thyroxine46 259.7CIITA, TGFB1, IL5, IL4, CD79A
14polyinosinic-polycytidylic acid468.7TNF, CIITA, IL4, IL5, CSF1
15n-formylmethionyl-leucylphenylalanine468.6IL5, RNASE3, TNF, CSF1
16budesonide46 52 1210.6RNASE3, IL4, CSF1, IL5, TNF
17fluticasone propionate46 52 62 1211.6TNF, RNASE3, IL4, IL5, CSF1
18ivig468.6TNF, IL5, CSF1, CD79A, IL4
19herbimycin a46 629.5IL5, MIF, TNF, IL4, ITGA6
20fmlp468.4TNF, CSF1, RNASE3, PRG2, IL5
21methacholine46 52 1210.3PRG2, IL4, CD79A, IL5, TGFB1, RNASE3
22n acetylcysteine468.3CTGF, CD79A, CSF1, IL4, RNASE3, TNF
23allergens468.3HLA-DRB1, CIITA, RNASE3, PRG2, IL4, CD79A
24gm-csf46 309.3IL5, TNF, TGFB1, CSF1, IL4
25il 10468.2TNF, TGFB1, IL4, IL5, CSF1
26h2o2468.2IL5, MIF, CTGF, TNF, RNASE3, CSF1
27carbamazepine46 52 1210.2TNF, IL4, IL5, CD79A
28paraffin468.1IL5, TGFB1, DST, MIF, IL4, CD79A
29methotrexate52 46 1210.1TNF, CD79A, IL5, ITGA6, TGFB1, HLA-DRB1
30nitric oxide46 25 1210.0RNASE3, PRG2, CTGF, MIF, ITGB4, SERPINH1
31cysteine468.0CIITA, CTGF, IL4, MIF, PRG2, CSF1
32lactate468.0TNF, RNASE3, MIF, CD79A, CTGF, TGFB1
33sb 20358046 629.0TGFB1, MIF, IL4, IL5, CTGF, TNF
34tacrolimus46 52 129.9IL5, CD79A, IL4, TGFB1, TNF
35ly294002467.9TGFB1, IL4, CSF1, TNF, IL5, CTGF
36arginine467.8CD79A, CSF1, IL5, IL4, RNASE3, PRG2
37actinomycin d467.7TGFB1, CIITA, PRG2, IL4, CSF1, TNF
38rantes467.5IL4, TNF, TGFB1, CIITA, RNASE3, CSF1
39thymidine46 258.5CIITA, IL5, TNF, TGFB1, MIF, IL4
40indomethacin46 30 62 1210.4TGFB1, TNF, PRG2, IL4, IL5, CSF1
41serine467.4ITGB4, TGFB1, CTGF, TNF, CIITA, CSF1
42cycloheximide467.4DST, CSF1, IL4, TGFB1, TNF, IL5
43cyclosporin a46 30 629.3CTGF, TGFB1, TNF, SERPINH1, CIITA, CD79A
44oligonucleotide467.3PRG2, ITGA6, RNASE3, DST, SERPINH1, CIITA
45histamine46 30 259.2IL5, IL4, CD79A, CSF1, TNF, TGFB1
46pge2467.0TGFB1, CD79A, CSF1, IL5, IL4, MIF
47dexamethasone46 52 30 129.9TGFB1, TNF, CSF1, CIITA, RNASE3, MIF
48retinoic acid46 257.7ITGA6, TGFB1, IL5, TNF, ITGB4, RNASE3
49vegf466.7TNF, CD79A, CSF1, CTGF, IL5, IL4
50tyrosine466.6CTGF, CSF1, HLA-DRB1, CIITA, IL4, SERPINH1

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Sources:
17Gene Ontology
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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:0300569.8DST, ITGA6, ITGB4
2basal plasma membraneGO:0099259.8ITGB4, ITGA6, DST
3MHC class II protein complexGO:0426139.6HLA-DRB1, HLA-DQB1
4basement membraneGO:0056049.4ITGB4, ITGA6, DST
5cell surfaceGO:0099868.4TNF, TGFB1, CIITA, MIF, ITGB4
6external side of plasma membraneGO:0098978.3HLA-DRB1, TNF, ITGA6, IL4, CD79A
7extracellular regionGO:0055767.4TNF, TGFB1, RNASE3, PRG2, MIF, IL5
8extracellular spaceGO:0056157.3CTGF, CSF1, IL5, IL4, MIF, SERPINH1
9plasma membraneGO:0058866.7HLA-DQB1, HLA-DRB1, TNF, TGFB1, ITGA6, ITGB4

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell motilityGO:04887010.1ITGB4, DST
2cell-matrix adhesionGO:00716010.1ITGA6, ITGB4, CTGF
3filopodium assemblyGO:04684710.1ITGA6, ITGB4
4positive regulation of phosphorylationGO:04232710.1ITGA6, MIF
5hemidesmosome assemblyGO:03158110.1ITGB4, ITGA6, DST
6positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, CIITA
7immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DRB1, HLA-DQB1
8humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DQB1, HLA-DRB1
9integrin-mediated signaling pathwayGO:0072299.8DST, ITGA6, ITGB4, CTGF
10positive regulation of cellular protein metabolic processGO:0322709.8CSF1, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.7HLA-DQB1, HLA-DRB1, CIITA
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7MIF, TNF
13positive regulation of B cell proliferationGO:0308909.7MIF, IL4, IL5
14positive regulation of podosome assemblyGO:0718039.7IL5, TNF
15positive regulation of collagen biosynthetic processGO:0329679.6TGFB1, CTGF
16positive regulation of osteoclast differentiationGO:0456729.5TNF, CSF1
17positive regulation of gene expressionGO:0106289.5TGFB1, CSF1, CTGF
18positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL4
19negative regulation of gene expressionGO:0106299.4CTGF, MIF, TNF
20cytokine-mediated signaling pathwayGO:0192219.4HLA-DQB1, HLA-DRB1, CIITA, IL5
21response to woundingGO:0096119.4TGFB1, DST, ITGB4, CTGF
22positive regulation of ERK1 and ERK2 cascadeGO:0703749.4CTGF, MIF, TNF
23positive regulation of cytokine secretionGO:0507159.4MIF, TNF
24positive regulation of protein complex assemblyGO:0313349.3TGFB1, TNF
25cellular response to organic cyclic compoundGO:0714079.2ITGA6, TGFB1, TNF
26positive regulation of MAP kinase activityGO:0434069.1MIF, TGFB1, TNF
27positive regulation of peptidyl-serine phosphorylationGO:0331389.1MIF, TGFB1, TNF
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1TNF, IL4, IL5
29osteoclast differentiationGO:0303169.0CSF1, TNF
30positive regulation of protein phosphorylationGO:0019349.0TNF, TGFB1, CTGF
31protein import into nucleus, translocationGO:0000608.9TNF, TGFB1
32negative regulation of transcription, DNA-templatedGO:0458928.5IL4, CIITA, TGFB1, TNF
33immune responseGO:0069558.4HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL4, IL5
34extracellular matrix organizationGO:0301988.4TNF, TGFB1, SERPINH1, DST, ITGA6, ITGB4
35positive regulation of transcription from RNA polymerase II promoterGO:0459448.4IL4, ITGA6, CIITA, TGFB1, TNF
36positive regulation of transcription, DNA-templatedGO:0458938.3TNF, TGFB1, CIITA, IL4, IL5
37inflammatory responseGO:0069548.3CSF1, IL5, MIF, CIITA, TGFB1, TNF

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.5DST, ITGA6, CTGF
2MHC class II receptor activityGO:0323959.3HLA-DRB1, HLA-DQB1
3growth factor activityGO:0080838.5CTGF, CSF1, IL5, IL4, TGFB1
4cytokine activityGO:0051258.2TNF, MIF, IL4, IL5, CSF1
5protein bindingGO:0055156.6TGFB1, CIITA, DST, MIF, ITGA6, ITGB4

Products for genes affiliated with Ocular Cicatricial Pemphigoid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Cicatricial Pemphigoid

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet