MCID: OCL020
MIFTS: 52

Ocular Cicatricial Pemphigoid malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ocular Cicatricial Pemphigoid

About this section
Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Ocular Cicatricial Pemphigoid:

Name: Ocular Cicatricial Pemphigoid 52 48 50 68
Pemphigoid, Benign Mucous Membrane 68
Pemphigoid, Ocular Cicatricial 48
Cicatricial Pemphigoid, Ocular 48
 
Mucous Membrane Pemphigoid 54
Mucosynechial Pemphigoid 54
Cicatricial Pemphigoid 54
Mucosal Pemphigoid 54

Characteristics:

Orphanet epidemiological data:

54
mucous membrane pemphigoid:
Inheritance: Not applicable; Age of onset: Adult; Age of death: normal life expectancy

HPO:

64
ocular cicatricial pemphigoid:
Inheritance: autosomal dominant inheritance

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

OMIM52 164185
Orphanet54 ORPHA46486
ICD10 via Orphanet31 L12.1

Summaries for Ocular Cicatricial Pemphigoid

About this section
NIH Rare Diseases:48 Ocular cicatricial pemphigoid (ocp) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes. in the early stages, people with ocp generally experience chronic or relapsing conjunctivitis that is often characterized by tearing, irritation, burning, and/or mucus drainage. if left untreated, ocp can progress to severe conjunctiva scarring and vision loss. involvement of other mucosal sites and the skin may also occur in ocp. the exact underlying cause is currently unknown. the treatment of ocp aims to slow disease progression and prevent complications. this usually involves long-term use of medications called immunomodulators which help regulate or normalize the immune system. last updated: 6/10/2015

MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to rheumatoid arthritis and cicatricial pemphigoid, and has symptoms including Array, Array and Array. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (Integrin Subunit Beta 4), and among its related pathways are Activation of TRKA receptors and IgA-Producing B Cells in the Intestine. Affiliated tissues include skin, eye and neutrophil, and related mouse phenotypes are Increased shRNA abundance and hearing/vestibular/ear.

Description from OMIM:52 164185

Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.4CD79A, CIITA, CSF1, HLA-DQB1, HLA-DRB1, IL4
2cicatricial pemphigoid10.9
3noonan syndrome 410.3CD36, SERPINH1, TGFB1
4marasmus10.2IL4, NGF, RNASE3
5endemic typhus10.2ACTA2, TGFB1, TGFBR2
6appendix carcinoid tumor10.2NGF, NTRK1, RNASE3
7peripheral artery disease10.2HLA-DRB1, IL4, TGFB1
8luminal breast carcinoma10.2HLA-DQB1, IL4, RNASE3
9global developmental delay-lung cysts-overgrowth-wilms tumor syndrome10.2PRG2, RNASE3
10apricot allergy10.2CD79A, IL4, RNASE3
11cataract10.2
12brown shrimp allergy10.2CD79A, RNASE3, TGFB1
13intravascular angioleiomyoma10.2CD79A, IL4, RNASE3
14germ cell and embryonal cancer10.2CD36, CTGF, TGFB1
15loiasis10.2CD79A, IL4, TGFB1
16central nervous system origin vertigo10.2CD79A, IL4, RNASE3
17bilateral parasagittal parieto-occipital polymicrogyria10.2HLA-DQB1, HLA-DRB1, TGFB1
18distal trisomy 14q10.2HLA-DQB1, HLA-DRB1, TGFB1
19mikulicz disease10.1CD79A, IL4, NGF
20zika fever10.1CD36, CTGF, SERPINH1, TGFB1
21mass syndrome10.1ACTA2, TGFB1, TGFBR2
22type 2 papillary adenoma of the kidney10.1CD79A, IL4, TGFBR2
23eyelid neoplasm10.1CD79A, IL4, RNASE3
24acquired polycythemia10.1CD79A, IL4, RNASE3
25ragweed sensitivity10.1HLA-DQB1, HLA-DRB1, TGFB1
26entropion10.1
27malignant renovascular hypertension10.1CD79A, NGF
28multiple epiphyseal dysplasia due to collagen 9 anomaly10.1IL4, PRG2, RNASE3
29actinic keratosis10.1CD79A, IL4, RNASE3
30malignant neoplasm of acoustic nerve10.1CTGF, IL4, TGFB1
31heart septal defect10.1CD79A, RNASE3
32xanthogranulomatous cholecystitis10.1CD79A, IL4, RNASE3
33cholera10.1CD79A, CTGF, TGFB1
34orbit alveolar rhabdomyosarcoma10.1CD79A, IL4, RNASE3, TGFB1
35spontaneous ocular nystagmus10.1IL4, RNASE3, TGFB1
36parasitic helminthiasis infectious disease10.1HLA-DQB1, HLA-DRB1, IL4
37scleroperikeratitis10.1NGF, NTRK1, TNFRSF1B
38barbiturate abuse10.1CD79A, HLA-DQB1, IL4
39acute chest syndrome10.1CD79A, IL4, RNASE3, TGFB1
40erythematosquamous dermatosis10.1HLA-DQB1, HLA-DRB1, IL4, TGFB1
41bilirubin metabolic disorder10.1CD79A, ITGA6, ITGB4
42tracheitis10.1CD79A, IL4, NGF, RNASE3
43thrombophlebitis migrans10.1CD79A, TGFB1, TNFRSF1B
44mucositis10.1
45nephrotic syndrome, type 210.0CD79A, ITGA6, ITGB4
46anaerobic meningitis10.0CD79A, HLA-DQB1, HLA-DRB1
47hypertrophic elongation of cervix10.0CD79A, IL4, TNFRSF1B
48aortic aneurysm, familial thoracic 610.0CD36, CTGF, SERPINH1, TGFB1
49cryptococcosis10.0HLA-DQB1, HLA-DRB1, TNFRSF1B
50clostridium difficile colitis10.0CD79A, HLA-DQB1, HLA-DRB1, IL4

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms & Phenotypes for Ocular Cicatricial Pemphigoid

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Symptoms by clinical synopsis from OMIM:

164185

Clinical features from OMIM:

164185

Human phenotypes related to Ocular Cicatricial Pemphigoid:

 54 64 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gingivitis64 54 Frequent (79-30%) HP:0000230
2 blindness64 54 Occasional (29-5%) HP:0000618
3 atypical scarring of skin64 54 Frequent (79-30%) HP:0000987
4 autoimmunity64 54 Very frequent (99-80%) HP:0002960
5 corneal opacity64 54 Occasional (29-5%) HP:0007957
6 abnormal blistering of the skin54 Occasional (29-5%)
7 oral mucosal blisters64 54 Very frequent (99-80%) HP:0200097
8 abnormality of the eye64 HP:0000478

GenomeRNAi Phenotypes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00327-A9.3CD36, CD79A, HLA-DQB1, IL4, SERPINH1

MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8CSF1, CTGF, ITGA6, ITGB4, MIF, NTRK1
2MP:00053828.0CSF1, CTGF, IL4, ITGA6, ITGB4, SERPINH1
3MP:00053908.0CD36, CIITA, CSF1, CTGF, IL4, SERPINH1
4MP:00053697.9ACTA2, CD36, CSF1, HLA-DQB1, NGF, NTRK1
5MP:00053677.8CD36, CD79A, HLA-DQB1, IL4, ITGA6, ITGB4
6MP:00053707.7CD36, CD79A, CSF1, HLA-DQB1, IL4, TGFB1
7MP:00028737.6CD79A, CIITA, CTGF, HLA-DQB1, IL4, MIF
8MP:00107717.3CSF1, CTGF, IL4, ITGA6, ITGB4, NGF
9MP:00053817.2CD36, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
10MP:00053797.1CD36, CIITA, CSF1, HLA-DQB1, IL4, ITGA6
11MP:00053916.9ACTA2, CD36, CSF1, CTGF, IL4, ITGA6
12MP:00053886.7CSF1, CTGF, HLA-DQB1, IL4, ITGA6, ITGB4
13MP:00053846.6CD36, CD79A, CSF1, CTGF, HLA-DQB1, IL4
14MP:00053856.6ACTA2, CD36, CSF1, CTGF, HLA-DQB1, ITGA6
15MP:00053766.6CD36, CD79A, CIITA, CSF1, CTGF, HLA-DQB1
16MP:00107686.6CD36, CSF1, CTGF, HLA-DQB1, IL4, ITGA6
17MP:00053786.5CD36, CSF1, CTGF, HLA-DQB1, IL4, ITGA6
18MP:00036315.9CD36, CD79A, CSF1, HLA-DQB1, IL4, ITGA6
19MP:00053875.5CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4
20MP:00053975.4CD36, CD79A, CIITA, CSF1, HLA-DQB1, IL4

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drugs for Ocular Cicatricial Pemphigoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mycophenolic acidapprovedPhase 395224280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
2
Mycophenolate mofetilapproved, investigationalPhase 3952128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
3Immunosuppressive AgentsPhase 313086
4Antibiotics, AntitubercularPhase 37180
5Anti-Bacterial AgentsPhase 311226
6
rituximabapprovedPhase 1, Phase 21692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
7
InfliximabapprovedPhase 1, Phase 2392170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
8
Riboflavinapproved, nutraceutical, vet_approvedPhase 1, Phase 217483-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
9
Folic Acidapproved, nutraceutical, vet_approvedPhase 1, Phase 2439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10Antirheumatic AgentsPhase 1, Phase 210956
11Trace ElementsPhase 1, Phase 26001
12Vitamin B ComplexPhase 1, Phase 24337
13VitaminsPhase 1, Phase 25282
14Pharmaceutical SolutionsPhase 1, Phase 28192
15Dermatologic AgentsPhase 1, Phase 25806
16MicronutrientsPhase 1, Phase 26001
17Photosensitizing AgentsPhase 1, Phase 2492
18Gastrointestinal AgentsPhase 1, Phase 28402
19FolateNutraceuticalPhase 1, Phase 24392
20Vitamin B9NutraceuticalPhase 1, Phase 24392
21Vitamin B2NutraceuticalPhase 1, Phase 2174
22ImmunoglobulinsPhase 16394
23AntibodiesPhase 16394
24Autoantibodies130

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid.Not yet recruitingNCT02993133Phase 3
2Clinical Trial Evaluating Rituximab in Ocular Cicatricial PemphigoidCompletedNCT00584935Phase 1, Phase 2
3Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter TrialRecruitingNCT02318485Phase 2
4Use of Cross-linked Donor Corneas as Carriers for the Boston KeratoprosthesisRecruitingNCT01582880Phase 1, Phase 2
5Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet TransplantationAvailableNCT02149732Phase 1, Phase 2
6Topical Infliximab in Autoimmune Eyes With KeratoprosthesisWithdrawnNCT02126020Phase 1, Phase 2
7The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem CellsUnknown statusNCT02202642Phase 1
8Topical Infliximab for Sterile Corneal MeltNot yet recruitingNCT02987686Phase 1
9Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory ConditionsWithdrawnNCT02042027Phase 1
10Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort StudyCompletedNCT00116090
11Immune Responses to Antigens in Non-infectious Eye Inflammatory DiseasesEnrolling by invitationNCT00357071

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

36
Skin, Eye, Neutrophil, Testes, T cells

Publications for Ocular Cicatricial Pemphigoid

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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid. (27275431)
2016
2
Update on ocular cicatricial pemphigoid and emerging treatments. (26708362)
2016
3
Characteristics of patients with ocular cicatricial pemphigoid referred to major tertiary hospital. (25863854)
2015
4
NGF Modulates trkANGFR/p75NTR in I+SMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP). (26569118)
2015
5
IgM ocular cicatricial pemphigoid: a unique insight into the immune system. (26632795)
2015
6
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
7
Neutrophil collagenase, gelatinase, and myeloperoxidase in tears of patients with stevens-johnson syndrome and ocular cicatricial pemphigoid. (23962653)
2014
8
Coexistence of ocular cicatricial pemphigoid with Stevens Johnson syndrome. (23826544)
2013
9
Outcomes of cataract surgery in ocular cicatricial pemphigoid. (23941520)
2013
10
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
11
The frequency of other autoimmune disorders in patients with ocular cicatricial pemphigoid. (21595864)
2012
12
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
13
Improvement in ocular cicatricial pemphigoid following treatment for porphyria cutanea tarda. (23118521)
2012
14
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
15
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
16
Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. (21279976)
2011
17
Peripheral ulcerative keratitis after cataract surgery in a patient with ocular cicatricial pemphigoid. (21822128)
2011
18
Ocular cicatricial pemphigoid: a review of clinical features, immunopathology, differential diagnosis, and current management. (21958173)
2011
19
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
20
Anterior lamellar excision and laissez-faire healing for aberrant lashes in ocular cicatricial pemphigoid. (19911023)
2010
21
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
22
Combination of rituximab and intravenous immunoglobulin for recalcitrant ocular cicatricial pemphigoid: a preliminary report. (20045562)
2010
23
Transscleral diode laser cyclophotocoagulation in a patient with ocular cicatricial pemphigoid. (19928727)
2009
24
T-helper 17 lymphocytes in ocular cicatricial pemphigoid. (19641634)
2009
25
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
26
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
27
Ocular cicatricial pemphigoid. (18762085)
2008
28
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
29
Exacerbation of undiagnosed ocular cicatricial pemphigoid after repair of involutional entropion. (18356734)
2008
30
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
31
Treatment of ocular cicatricial pemphigoid with the tumour necrosis factor alpha antagonist etanercept. (17225020)
2007
32
Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid. (17488321)
2007
33
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (17179127)
2007
34
In vivo confocal microscopy of ocular cicatricial pemphigoid. (16583645)
2006
35
Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. (16950250)
2006
36
Ocular cicatricial pemphigoid. (16954792)
2006
37
Dapsone induced haemolytic anaemia in patients treated for ocular cicatricial pemphigoid. (16547343)
2006
38
Ocular cicatricial pemphigoid: manifestations and management. (15967079)
2005
39
Blood group related antigens in ocular cicatricial pemphigoid. (15377543)
2004
40
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
41
Role of macrophage migration inhibitory factor in conjunctival pathology in ocular cicatricial pemphigoid. (15037585)
2004
42
Ocular cicatricial pemphigoid: pathogenesis, diagnosis and treatment. (15388075)
2004
43
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
44
Ocular cicatricial pemphigoid review. (15349045)
2004
45
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
46
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
47
Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. (12882790)
2003
48
Amniotic membrane transplantation elicits goblet cell repopulation after conjunctival reconstruction in a case of severe ocular cicatricial pemphigoid. (12631023)
2003
49
Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid. (12657600)
2003
50
Ocular cicatricial pemphigoid: all conjunctival scarring is not trachoma. (14750630)
2003

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9NGF, NTRK1
29.8CD36, IL4, TGFB1
39.8IL4, TGFB1, TGFBR2
49.7CTGF, IL4, TGFB1
5
Show member pathways
9.6CTGF, TGFB1, TGFBR2
69.5CSF1, IL4, TNFRSF1B
79.5CSF1, HLA-DRB1, IL4, TGFB1
89.4CD36, CD79A, CSF1, IL4
99.3CD36, IL4, TGFB1, TNFRSF1B
109.3CSF1, HLA-DQB1, HLA-DRB1, TGFB1
119.2HLA-DQB1, HLA-DRB1, TGFB1, TGFBR2
12
Show member pathways
9.2ITGA6, ITGB4, TGFB1
13
Show member pathways
9.1HLA-DQB1, HLA-DRB1, IL4, TGFB1, TGFBR2
148.9CIITA, HLA-DQB1, HLA-DRB1, TGFB1
158.8CSF1, IL4, ITGA6, ITGB4, NGF
16
Show member pathways
8.5CD79A, HLA-DQB1, HLA-DRB1, IL4, TNFRSF1B
17
Show member pathways
8.4ACTA2, ITGA6, ITGB4, NTRK1, TGFB1, TGFBR2
188.3CD36, CSF1, HLA-DQB1, HLA-DRB1, IL4, ITGA6
198.3CTGF, ITGA6, ITGB4, NGF, NTRK1, TGFB1
20
Show member pathways
8.1ACTA2, HLA-DQB1, HLA-DRB1, ITGA6, ITGB4, NTRK1
21
Show member pathways
7.9CIITA, HLA-DQB1, HLA-DRB1, IL4, PRG2, RNASE3
22
Show member pathways
7.9CIITA, HLA-DQB1, HLA-DRB1, IL4, ITGA6, TGFB1
23
Show member pathways
7.8ACTA2, CSF1, CTGF, IL4, NGF, NTRK1
24
Show member pathways
7.7CD36, CIITA, CSF1, HLA-DQB1, HLA-DRB1, IL4
25
Show member pathways
7.3CTGF, IL4, ITGA6, ITGB4, NGF, NTRK1
26
Show member pathways
7.0ACTA2, CSF1, CTGF, IL4, ITGA6, ITGB4
27
Show member pathways
7.0ACTA2, CD79A, CTGF, ITGA6, ITGB4, NGF
28
Show member pathways
6.5ACTA2, CD79A, CTGF, HLA-DQB1, HLA-DRB1, ITGA6
29
Show member pathways
6.3ACTA2, CSF1, CTGF, IL4, ITGA6, ITGB4
30
Show member pathways
6.2CD36, CD79A, CIITA, CSF1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:003066610.3CD36, HLA-DQB1, HLA-DRB1
2hemidesmosomeGO:003005610.1ITGA6, ITGB4
3external side of plasma membraneGO:00098979.0CD36, CD79A, HLA-DRB1, IL4, ITGA6, TGFBR2
4membrane raftGO:00451218.8CD36, CD79A, SERPINH1, TGFBR2, TNFRSF1B
5extracellular spaceGO:00056158.8ACTA2, CD36, CSF1, CTGF, IL4, MIF
6extracellular regionGO:00055768.3CSF1, CTGF, IL4, MIF, NGF, PRG2
7cell surfaceGO:00099868.1CD36, CIITA, HLA-DRB1, ITGA6, ITGB4, MIF

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1common-partner SMAD protein phosphorylationGO:000718210.8TGFB1, TGFBR2
2pathway-restricted SMAD protein phosphorylationGO:006038910.7TGFB1, TGFBR2
3positive regulation of mononuclear cell migrationGO:007167710.7IL4, TGFB1
4response to cholesterolGO:007072310.6TGFB1, TGFBR2
5myeloid dendritic cell differentiationGO:004301110.6IL4, TGFB1, TGFBR2
6antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.5HLA-DQB1, HLA-DRB1
7humoral immune response mediated by circulating immunoglobulinGO:000245510.5HLA-DQB1, HLA-DRB1
8immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.5HLA-DQB1, HLA-DRB1
9positive regulation of MHC class II biosynthetic processGO:004534810.3CIITA, IL4
10positive regulation of Ras protein signal transductionGO:004657910.3CSF1, NGF, NTRK1
11B cell differentiationGO:003018310.3CD79A, IL4, NTRK1
12positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.3CD36, IL4, MIF, TGFB1
13amelogenesisGO:009718610.2ITGA6, ITGB4
14hemidesmosome assemblyGO:003158110.2ITGA6, ITGB4
15cellular response to growth factor stimulusGO:007136310.2NTRK1, TGFB1, TNFRSF1B
16nail developmentGO:003587810.2ITGA6, ITGB4
17response to glucoseGO:000974910.2CTGF, TGFB1, TGFBR2
18negative regulation of gene expressionGO:001062910.2CD36, CTGF, MIF, TGFB1
19response to organic cyclic compoundGO:00140709.9CTGF, IL4, TGFB1, TGFBR2
20positive regulation of cell proliferationGO:00082849.9CSF1, CTGF, IL4, TGFB1, TGFBR2
21interferon-gamma-mediated signaling pathwayGO:00603339.9CIITA, HLA-DQB1, HLA-DRB1
22integrin-mediated signaling pathwayGO:00072299.8CTGF, ITGA6, ITGB4
23regulation of cell proliferationGO:00421279.8MIF, TGFB1, TGFBR2, TNFRSF1B
24positive regulation of ERK1 and ERK2 cascadeGO:00703749.8CD36, CTGF, MIF, NTRK1, TGFB1
25positive regulation of protein phosphorylationGO:00019349.8CTGF, IL4, MIF, NTRK1, TGFB1
26digestive tract developmentGO:00485659.8ITGA6, ITGB4, TGFB1, TGFBR2
27positive regulation of gene expressionGO:00106289.7ACTA2, CSF1, CTGF, NGF, TGFB1
28response to woundingGO:00096119.7CTGF, ITGB4, TGFB1
29neutrophil degranulationGO:00433129.4CD36, MIF, PRG2, RNASE3, TNFRSF1B
30immune system processGO:00023769.4CD79A, CSF1, HLA-DRB1, MIF, PRG2
31inflammatory responseGO:00069549.4CIITA, CSF1, MIF, TGFB1, TNFRSF1B
32agingGO:00075689.0CIITA, CTGF, NTRK1, TGFB1, TGFBR2, TNFRSF1B
33immune responseGO:00069558.4CD36, CIITA, HLA-DQB1, HLA-DRB1, IL4, PRG2

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.2CSF1, IL4, MIF, TGFB1
2MHC class II receptor activityGO:003239510.0HLA-DQB1, HLA-DRB1
3type I transforming growth factor beta receptor bindingGO:003471310.0TGFB1, TGFBR2
4insulin-like growth factor I bindingGO:00319949.8ITGA6, ITGB4
5neuregulin bindingGO:00381329.7ITGA6, ITGB4
6growth factor activityGO:00080839.6CSF1, CTGF, IL4, NGF, TGFB1

Sources for Ocular Cicatricial Pemphigoid

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet