MCID: OCL020
MIFTS: 37

Ocular Cicatricial Pemphigoid malady

Summaries for Ocular Cicatricial Pemphigoid

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to cicatricial pemphigoid and conjunctivitis. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are HTLV-I infection and Hypertrophic cardiomyopathy (HCM). The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and embryogenesis.

Aliases & Classifications for Ocular Cicatricial Pemphigoid

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
See all sources

Aliases & Descriptions:

ocular cicatricial pemphigoid 42 44 60
pemphigoid, benign mucous membrane 60
pemphigoid, ocular cicatricial 42
cicatricial pemphigoid, ocular 42


Related Diseases for Ocular Cicatricial Pemphigoid

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1cicatricial pemphigoid31.9ITGB4, ITGA6, DST, CD79A
2conjunctivitis30.6CD79A, RNASE3
3pemphigus30.5CD79A, DST
4bullous pemphigoid30.5IL5, RNASE3, CD79A, DST, PRG2, CIITA
5neutropenia30.3CSF1
6glaucoma30.3CTGF
7keratoconjunctivitis30.3RNASE3, IL5
8sjogren's syndrome30.3CD79A, CIITA
9rheumatoid arthritis30.3HLA-DRB1, CIITA
10arthritis30.3CSF1, TNF, CTGF, HLA-DRB1, CIITA, MIF
11stevens-johnson syndrome10.7
12cataract10.6
13cicatricial entropion10.5
14entropion10.5
15mucous membrane pemphigoid10.5
16chronic conjunctivitis10.4
17keratitis10.4
18brunsting-perry syndrome10.3
19porphyria cutanea tarda10.2
20trachoma10.2
21mucoepidermoid carcinoma10.2
22corneal ulcer10.2
23porphyria10.2
24scleral disease10.2
25neuritis10.0CIITA
26alopecia areata10.0CIITA
27kawasaki disease10.0CIITA
28vitiligo10.0CIITA
29myocarditis10.0CIITA
30encephalitis10.0CIITA
31cervical intraepithelial neoplasia10.0ITGB4
32cystic fibrosis10.0RNASE3
33myositis10.0CIITA
34lyme disease10.0CIITA
35bronchopulmonary dysplasia10.0RNASE3
36adult t-cell leukemia10.0SERPINH1
37wegener's granulomatosis10.0CIITA
38diabetic retinopathy10.0CTGF
39collagenous colitis10.0RNASE3
40rhabdomyosarcoma10.0CTGF
41sarcoma10.0CSF1
42malignant mesothelioma10.0RNASE3
43acute pancreatitis10.0MIF
44stroke, ischemic10.0CSF1
45systemic scleroderma10.0CTGF
46eosinophilic esophagitis10.0IL5
47acute leukemia10.0CSF1
48bacterial vaginosis10.0SERPINH1
49eosinophilic gastroenteritis10.0IL5
50purpura10.0CD79A

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Clinical Features for Ocular Cicatricial Pemphigoid

About this section

Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ocular Cicatricial Pemphigoid

Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

Search NIH Clinical Center for Ocular Cicatricial Pemphigoid

Search CenterWatch for Ocular Cicatricial Pemphigoid

Genetic Tests for Ocular Cicatricial Pemphigoid

About this section

Anatomical Context for Ocular Cicatricial Pemphigoid

About this section

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.1DST, ITGB4
2MP:00053809.7SERPINH1, ITGA6, CTGF
3MP:00053679.7ITGB4, DST, HLA-DQB1
4MP:00053719.7CSF1, SERPINH1, DST
5MP:00053899.2DST, TGFB1, CSF1
6MP:00107719.1TGFB1, DST, ITGA6, ITGB4, CTGF
7MP:00053888.4SERPINH1, TGFB1, PRG2, ITGA6, ITGB4, HLA-DQB1
8MP:00036318.4ITGB4, TGFB1, CSF1, HLA-DQB1, ITGA6, SERPINH1
9MP:00053798.0CIITA, ITGA6, TNF, CSF1, TGFB1, IL4
10MP:00053827.7CSF1, SERPINH1, IL4, ITGA6, ITGB4, TGFB1
11MP:00053857.6SERPINH1, CSF1, TGFB1, CTGF, HLA-DQB1, ITGB4
12MP:00053707.6TNF, HLA-DQB1, CSF1, IL5, IL4, TGFB1
13MP:00053817.0IL5, DST, IL4, SERPINH1, CTGF, TGFB1
14MP:00053786.7ITGA6, HLA-DQB1, CTGF, DST, IL5, IL4
15MP:00053846.7ITGB4, CSF1, TGFB1, IL4, CD79A, MIF
16MP:00107686.4HLA-DQB1, SERPINH1, DST, ITGA6, IL4, TGFB1
17MP:00053766.2TGFB1, CSF1, MIF, DST, CIITA, ITGB4
18MP:00053876.2TGFB1, CSF1, TNF, HLA-DQB1, ITGB4, ITGA6
19MP:00053976.0CIITA, ITGA6, HLA-DQB1, TNF, PRG2, TGFB1

Publications for Ocular Cicatricial Pemphigoid

About this section

Genetic Variations for Ocular Cicatricial Pemphigoid

About this section

Expression for genes affiliated with Ocular Cicatricial Pemphigoid

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ocular Cicatricial Pemphigoid

Search GEO for disease gene expression data for Ocular Cicatricial Pemphigoid.

Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 53Reactome, 12EMD Millipore
See all sources

Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1HLA-DQB1
2
Hide members
10.0ITGA6, ITGB4
39.9HLA-DRB1
4
Hide members
9.9CSF1, IL5
59.7IL4, IL5
69.6ITGB4, ITGA6, DST
79.6ITGA6, ITGB4, DST
8
Hide members
9.4DST, SERPINH1, ITGB4, ITGA6
99.3IL4, ITGA6, ITGB4, CSF1
10
Hide members
9.2CTGF, TGFB1, ITGA6, ITGB4
11
Hide members
9.2ITGB4, CTGF, ITGA6, PRG2
12
Immune response NFAT in immune response
Hide members
9.1CD79A, HLA-DRB1, HLA-DQB1
139.1TGFB1, TNF
14
Hide members
9.1ITGA6, HLA-DQB1, HLA-DRB1, ITGB4
15
Hide members
9.0IL5, CTGF, TGFB1, CSF1
16
Hide members
9.0HLA-DQB1, IL5, CIITA, HLA-DRB1
17
Hide members
8.9IL4, TNF, IL5
188.9TNF, IL4, IL5
19
Hide members
8.7HLA-DQB1, HLA-DRB1, ITGA6, CIITA, IL5
208.7IL4, TGFB1, TNF
21
Hide members
8.6PRG2, ITGB4, IL5, CSF1, ITGA6, CTGF
22
Hide members
8.5TNF, CD79A, IL5, IL4
23
Hide members
8.5IL5, TNF, CD79A, IL4
24
Hide members
8.0TNF, HLA-DRB1, CIITA, IL4, HLA-DQB1
257.9HLA-DRB1, HLA-DQB1, TNF, TGFB1, CIITA
26
Hide members
7.9TGFB1, ITGB4, HLA-DRB1, HLA-DQB1, CTGF, CD79A
27
Hide members
7.9HLA-DRB1, HLA-DQB1, IL4, TNF, CD79A
287.7IL4, ITGA6, IL5, HLA-DRB1, TNF, CSF1
29
Hide members
7.6IL4, TGFB1, ITGA6, IL5, ITGB4, TNF
30
Hide members
7.3ITGA6, CSF1, TNF, CTGF, ITGB4, IL5
31
Hide members
6.9CIITA, HLA-DRB1, IL5, HLA-DQB1, PRG2, IL4

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
See all sources

Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5DST
2pge24410.4TGFB1
3ivig4410.2CSF1, CD79A
4gm-csf44 2811.1TNF
5beclomethasone dipropionate449.9RNASE3, CSF1, IL5
6unicap449.9IL5, RNASE3, CD79A
7h2o2449.9CD79A, CTGF, MIF
8indomethacin44 59 28 1112.7CSF1, IL5, PRG2
9sodium cromoglycate449.7CD79A, IL5, RNASE3
10nedocromil sodium449.5IL5, RNASE3, CSF1, IL4
11cyclosporin a44 28 5911.5CTGF, RNASE3, CIITA, CD79A, SERPINH1
12salbutamol44 49 28 11 2413.5IL5, CD79A, RNASE3, CSF1
13kalinin449.5ITGB4, ITGA6, DST
14praziquantel44 1110.4IL5, RNASE3, CD79A, IL4
15ltc4449.4PRG2, IL5, RNASE3, CSF1
16anti-fungal449.4IL5, RNASE3, CD79A, CSF1
17glatiramer acetate44 1110.2HLA-DRB1, CIITA, IL4, IL5
18fmlp449.2CSF1, RNASE3, IL5, PRG2
19methylcellulose449.1TGFB1, IL4, IL5, CSF1
20pranlukast44 28 1111.0IL5, RNASE3, TNF, IL4
21dexamethasone44 49 28 1111.9IL5, RNASE3, TGFB1, CD79A, CTGF, CIITA
22n-formylmethionyl-leucylphenylalanine448.8TNF, RNASE3, IL5, CSF1
23thyroxine44 249.8CIITA, IL4, CD79A, TGFB1, IL5
24polyinosinic-polycytidylic acid448.8IL4, IL5, CIITA, CSF1, TNF
25budesonide44 49 1110.7TNF, CSF1, RNASE3, IL4, IL5
26fluticasone propionate44 49 59 1111.7IL4, RNASE3, CSF1, TNF, IL5
27prednisolone44 28 1110.7CSF1, CD79A, RNASE3, IL5, TNF
28herbimycin a44 599.7MIF, IL5, IL4, ITGA6, TNF
29carbamazepine44 49 1110.5TNF, CD79A, IL5, IL4
30methacholine44 119.5IL5, CD79A, RNASE3, IL4, PRG2, TGFB1
31il 10448.5CSF1, TNF, TGFB1, IL4, IL5
32rantes448.3IL4, CIITA, CSF1, TNF, RNASE3, TGFB1
33n acetylcysteine448.3CD79A, IL4, TNF, CSF1, CTGF, RNASE3
34paraffin448.2IL4, IL5, TGFB1, DST, CSF1, MIF
35allergens448.2IL4, IL5, RNASE3, CD79A, PRG2, CIITA
36sb 20358044 599.1CTGF, MIF, TNF, IL5, IL4, TGFB1
37ly294002448.1CTGF, TGFB1, IL4, CSF1, TNF, IL5
38lactate448.0CSF1, CTGF, MIF, CD79A, RNASE3, TGFB1
39nitric oxide44 11 2410.0SERPINH1, PRG2, TNF, RNASE3, MIF, CIITA
40methotrexate44 49 1110.0ITGA6, IL5, TNF, TGFB1, HLA-DRB1, CD79A
41cysteine447.9CSF1, IL4, IL5, CD79A, MIF, CIITA
42actinomycin d447.9CIITA, CSF1, TNF, PRG2, IL4, TGFB1
43serine447.8TGFB1, MIF, CIITA, ITGB4, TNF, CSF1
44thymidine44 248.7CSF1, TNF, CTGF, IL5, IL4, TGFB1
45tacrolimus44 49 119.7TGFB1, IL4, CD79A, IL5, TNF
46histamine44 28 249.3PRG2, CD79A, RNASE3, IL4, CSF1, TGFB1
47oligonucleotide447.3TGFB1, CTGF, SERPINH1, RNASE3, DST, PRG2
48vegf446.8CD79A, MIF, ITGA6, CTGF, CSF1, TNF
49retinoic acid44 247.8ITGA6, PRG2, MIF, CD79A, RNASE3, IL5
50tyrosine446.6IL5, IL4, SERPINH1, MIF, PRG2, RNASE3

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:0300569.7ITGB4, DST, ITGA6
2basal plasma membraneGO:0099259.5ITGB4, ITGA6, DST
3basement membraneGO:0056049.3ITGB4, DST, ITGA6
4external side of plasma membraneGO:0098978.0ITGA6, TNF, HLA-DRB1, IL4, CD79A
5extracellular regionGO:0055767.5MIF, PRG2, CTGF, TNF, RNASE3, IL5
6extracellular spaceGO:0056157.4MIF, SERPINH1, IL4, IL5, CTGF, TNF

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, CIITA
2hemidesmosome assemblyGO:03158110.0ITGB4, DST, ITGA6
3cell-matrix adhesionGO:0071609.9ITGB4, ITGA6, CTGF
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DQB1, HLA-DRB1
5positive regulation of B cell proliferationGO:0308909.8IL5, IL4, MIF
6positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7TNF, MIF
7integrin-mediated signaling pathwayGO:0072299.7DST, ITGB4, CTGF, ITGA6
8humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
9positive regulation of podosome assemblyGO:0718039.6IL5, TNF
10positive regulation of cellular protein metabolic processGO:0322709.6CSF1, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.5CIITA, HLA-DRB1, HLA-DQB1
12response to woundingGO:0096119.4CTGF, ITGB4, DST, TGFB1
13positive regulation of chemokine biosynthetic processGO:0450809.4IL4, TNF
14negative regulation of gene expressionGO:0106299.3MIF, CTGF, TNF
15cytokine-mediated signaling pathwayGO:0192219.3IL5, CIITA, HLA-DRB1, HLA-DQB1
16positive regulation of MAP kinase activityGO:0434069.2TNF, MIF, TGFB1
17positive regulation of peptidyl-serine phosphorylationGO:0331389.2MIF, TNF, TGFB1
18positive regulation of ERK1 and ERK2 cascadeGO:0703749.1MIF, CTGF, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL5, IL4, TNF
20positive regulation of protein phosphorylationGO:0019348.9TNF, CTGF, TGFB1
21positive regulation of protein complex assemblyGO:0313348.8TGFB1, TNF
22inflammatory responseGO:0069548.6CSF1, TNF, TGFB1, IL5, MIF
23extracellular matrix organizationGO:0301988.4ITGA6, TGFB1, SERPINH1, DST, ITGB4, TNF
24positive regulation of transcription, DNA-dependentGO:0458938.4IL4, CIITA, TGFB1, TNF, IL5
25immune responseGO:0069558.4IL5, PRG2, CIITA, HLA-DRB1, HLA-DQB1, IL4
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TNF, ITGA6, CIITA, TGFB1, IL4

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQB1
2integrin bindingGO:0051789.3CTGF, ITGA6, DST
3growth factor activityGO:0080838.6IL4, TGFB1, IL5, CTGF, CSF1
4cytokine activityGO:0051258.2CSF1, TNF, MIF, IL5, IL4

Products for genes affiliated with Ocular Cicatricial Pemphigoid

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Cicatricial Pemphigoid

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet