MCID: OCL020
MIFTS: 51

Ocular Cicatricial Pemphigoid malady

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Summaries for Ocular Cicatricial Pemphigoid

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MalaCards based summary: Ocular Cicatricial Pemphigoid, also known as pemphigoid, benign mucous membrane, is related to conjunctivitis and bullous pemphigoid. An important gene associated with Ocular Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are Cell junction organization and Alpha6-Beta4 Integrin Signaling Pathway. The compounds unicap and beclomethasone dipropionate have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and neutrophil, and related mouse phenotypes are normal and limbs/digits/tail.

Aliases & Classifications for Ocular Cicatricial Pemphigoid

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
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Ocular Cicatricial Pemphigoid, Aliases & Descriptions:

Name: Ocular Cicatricial Pemphigoid 42 44 62
Pemphigoid, Benign Mucous Membrane 62
 
Pemphigoid, Ocular Cicatricial 42
Cicatricial Pemphigoid, Ocular 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Ocular Cicatricial Pemphigoid

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Diseases related to Ocular Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.3CD79A, RNASE3
2bullous pemphigoid31.3ITGA6, DST
3pemphigus31.2CD79A, DST
4keratoconjunctivitis31.1RNASE3, IL5
5rheumatoid arthritis30.9HLA-DRB1, CIITA
6pemphigus vulgaris30.9CIITA, DST, HLA-DRB1
7arthritis29.1CIITA, MIF, HLA-DRB1, TNF, TGFB1, CTGF
8cicatricial pemphigoid11.4
9stevens-johnson syndrome10.7
10cataract10.6
11entropion10.6
12collagenous colitis10.6RNASE3
13kindler syndrome10.6ITGB4
14strongyloidiasis10.5IL5
15giardiasis10.5CD79A
16paragonimiasis10.5IL5
17amebiasis10.5CD79A
18eosinophilic gastroenteritis10.5IL5
19eosinophilia-myalgia syndrome10.5IL5
20epidermolysis bullosa simplex with pyloric atresia10.5ITGA6, ITGB4
21exanthem10.5CD79A
22cryptosporidiosis10.5CD79A
23epidermolysis bullosa with pyloric atresia10.5ITGB4, ITGA6
24leprosy10.5HLA-DRB1
25bronchitis10.4RNASE3, CD79A
26keratitis10.4
27aspergillosis10.4CD79A, CSF1
28immunoglobulin a vasculitis10.4RNASE3, CD79A
29blau syndrome10.4TNF
30chronic eosinophilic pneumonia10.4RNASE3, IL5
31giant papillary conjunctivitis10.4IL5, RNASE3
32helminthiasis10.4IL5, RNASE3
33onchocerciasis10.4IL5, RNASE3
34churg-strauss syndrome10.4IL5, RNASE3
35herpes gestationis10.4RNASE3, DST
36eosinophilic pneumonia10.4IL5, RNASE3
37gastroenteritis10.4CD79A
38epidermolysis bullosa simplex10.3DST, ITGB4
39membranous glomerulonephritis10.3CD79A, CTGF
40periapical granuloma10.3IL4
41junctional epidermolysis bullosa10.3ITGA6, ITGB4, DST
42epidermolysis bullosa10.3DST, ITGA6, ITGB4
43bullous skin disease10.3IL5, DST
44immunoglobulin alpha deficiency10.3HLA-DQB1, CD79A
45kimura disease10.3PRG2, IL5, RNASE3
46bronchiectasis10.3CD79A, RNASE3
47hypereosinophilic syndrome10.3RNASE3, PRG2, IL5
48esophagitis10.3PRG2, IL5
49epidermolysis bullosa acquisita10.3CD79A, DST, ITGB4
50dermatitis herpetiformis10.3HLA-DQB1, CD79A

Graphical network of the top 20 diseases related to Ocular Cicatricial Pemphigoid:



Diseases related to ocular cicatricial pemphigoid

Symptoms for Ocular Cicatricial Pemphigoid

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Drugs & Therapeutics for Ocular Cicatricial Pemphigoid

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Drug clinical trials:

Search ClinicalTrials for Ocular Cicatricial Pemphigoid

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Genetic Tests for Ocular Cicatricial Pemphigoid

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Anatomical Context for Ocular Cicatricial Pemphigoid

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MalaCards organs/tissues related to Ocular Cicatricial Pemphigoid:

32
Testes, T cells, Neutrophil

Animal Models for Ocular Cicatricial Pemphigoid or affiliated genes

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MGI Mouse Phenotypes related to Ocular Cicatricial Pemphigoid:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CTGF, CD79A, IL4, MIF, CIITA, HLA-DQB1
2MP:00053718.4TNF, SERPINH1, DST, ITGA6, CSF1, CTGF
3MP:00020068.2TNF, TGFB1, MIF, ITGA6, IL5
4MP:00053678.0HLA-DQB1, TGFB1, DST, ITGA6, ITGB4, IL4
5MP:00053807.8TNF, TGFB1, SERPINH1, ITGA6, IL5, CTGF
6MP:00053857.6HLA-DQB1, TNF, TGFB1, SERPINH1, ITGA6, ITGB4
7MP:00053827.6TNF, TGFB1, SERPINH1, ITGA6, ITGB4, IL4
8MP:00053707.5HLA-DQB1, TNF, TGFB1, IL4, IL5, CSF1
9MP:00053797.5HLA-DQB1, TNF, TGFB1, CIITA, ITGA6, IL4
10MP:00053917.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
11MP:00107717.4TNF, TGFB1, DST, ITGA6, ITGB4, IL4
12MP:00053897.1HLA-DQB1, TNF, TGFB1, DST, IL4, IL5
13MP:00053867.1HLA-DQB1, TNF, TGFB1, DST, ITGB4, IL5
14MP:00053846.8HLA-DQB1, TNF, TGFB1, MIF, ITGA6, ITGB4
15MP:00053816.8SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
16MP:00036316.7SERPINH1, TGFB1, TNF, HLA-DQB1, DST, ITGA6
17MP:00107686.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
18MP:00053786.6HLA-DQB1, TNF, TGFB1, SERPINH1, DST, ITGA6
19MP:00053886.3CTGF, HLA-DQB1, TNF, TGFB1, SERPINH1, PRG2
20MP:00053766.1DST, CIITA, TGFB1, TNF, HLA-DQB1, MIF
21MP:00053876.0PRG2, CIITA, TGFB1, TNF, HLA-DQB1, MIF
22MP:00053975.8DST, CIITA, TGFB1, TNF, HLA-DQB1, PRG2

Publications for Ocular Cicatricial Pemphigoid

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Articles related to Ocular Cicatricial Pemphigoid:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Low-dose pulsed intravenous cyclophosphamide for severe ocular cicatricial pemphigoid in elderly patients. (25014147)
2014
2
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
3
Profile of local interleukin expression in a cohort of ocular cicatricial pemphigoid patients. (23081979)
2012
4
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
5
Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. (21552176)
2011
6
Scleral lenses and ocular cicatricial pemphigoid. (20697280)
2010
7
Transscleral diode laser cyclophotocoagulation and ocular cicatricial pemphigoid. (20635815)
2010
8
Combination treatment of intravenous immunoglobulin and cultivated oral mucosal epithelial transplantation for ocular cicatricial pemphigoid. (21686527)
2009
9
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management. (19770718)
2009
10
Ocular cicatricial pemphigoid. (18762085)
2008
11
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
12
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
13
Ocular cicatricial pemphigoid. (16954792)
2006
14
A new method for measuring progression in patients with ocular cicatricial pemphigoid. (14769592)
2004
15
Intravenous immunoglobulin therapy in patients with ocular-cicatricial pemphigoid: a long-term follow-up. (15234140)
2004
16
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
17
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
18
Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. (12714635)
2003
19
Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. (12623807)
2003
20
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. (11772589)
2002
21
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
22
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
23
The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. (10946315)
2000
24
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
25
Linear IgA dermatosis mimicking ocular cicatricial pemphigoid. (10555732)
1999
26
Tetracycline and niacinamide: treatment alternatives in ocular cicatricial pemphigoid. (10190074)
1999
27
Pure ocular cicatricial pemphigoid. A distinct immunopathologic subset of cicatricial pemphigoid. (9951490)
1999
28
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. (9756444)
1998
29
Treatment of ocular cicatricial pemphigoid with intravenous gammaglobulin. (9689316)
1998
30
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
31
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
32
Conjunctival scarring after eyelid surgery as first sign of ocular cicatricial pemphigoid. (9076789)
1997
33
Ocular cicatricial pemphigoid and ocular manifestations of pemphigus vulgaris. (9269598)
1997
34
Conjunctival fibrosis in ocular cicatricial pemphigoid--the role of cytokines. (9268585)
1997
35
Progression of disease in ocular cicatricial pemphigoid. (8703876)
1996
36
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid. (8759268)
1996
37
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
38
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
39
Ocular cicatricial pemphigoid. A case report of monozygotic twins discordant for the disease. (7864752)
1995
40
Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. (9097741)
1995
41
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
42
Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid. (7800360)
1994
43
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
44
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
45
Systemic chemotherapy for ocular cicatricial pemphigoid. (2055022)
1991
46
Ocular cicatricial pemphigoid and oesophageal carcinoma. (2203219)
1990
47
Scanning electron microscopy of conjunctival surfaces in patients with ocular cicatricial pemphigoid. (3535522)
1986
48
Ocular cicatricial pemphigoid with granular IgA and complement deposition. (3904684)
1985
49
Enigma of ocular cicatricial pemphigoid. A comparative study of clinical and immunological findings. (398602)
1979
50
Ocular cicatricial pemphigoid associated with practolol therapy. (773404)
1976

Variations for Ocular Cicatricial Pemphigoid

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Expression for genes affiliated with Ocular Cicatricial Pemphigoid

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Expression patterns in normal tissues for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways for genes affiliated with Ocular Cicatricial Pemphigoid

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Pathways related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DST, ITGA6, ITGB4
2
Show member pathways
9.7DST, ITGA6, ITGB4
39.6IL5, IL4
49.4CIITA, IL4, CD79A
5
Show member pathways
9.4SERPINH1, DST, ITGA6, ITGB4
6
Show member pathways
Proteogylcan syndecan-mediated signaling events37
9.4ITGB4, ITGA6, TGFB1
79.4HLA-DQB1, HLA-DRB1, ITGA6
89.3IL4, TGFB1
99.3CSF1, TNF
10
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.3CD79A, HLA-DRB1, HLA-DQB1
119.2ITGA6, ITGB4, IL4, CSF1
12
Show member pathways
9.2HLA-DQB1, HLA-DRB1, ITGA6, ITGB4
13
Show member pathways
9.0IL5, CIITA, HLA-DRB1, HLA-DQB1
149.0TGFB1, TNF
159.0IL5, IL4, TGFB1
16
Show member pathways
8.9TGFB1, PRG2, ITGA6, ITGB4
17
Show member pathways
8.9ITGB4, ITGA6, PRG2, TGFB1
18
Show member pathways
8.8TGFB1, SERPINH1, DST, ITGA6, ITGB4
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.8IL5, IL4, TNF
208.8TNF, IL4, IL5
218.7TNF, TGFB1, MIF
228.7TNF, TGFB1, CSF1
23
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.6ITGB4, ITGA6, TGFB1, TNF
24
Show member pathways
8.6TNF, TGFB1, ITGA6, ITGB4
25
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.5TNF, IL4, IL5, CD79A
26
Show member pathways
8.3TNF, TGFB1, ITGA6, ITGB4, CTGF
278.2TNF, TGFB1, MIF, IL4
288.2TGFB1, TNF, HLA-DRB1, HLA-DQB1
29
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TNF, CIITA, IL4
30
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TGFB1, ITGA6, ITGB4, CD79A
31
Show member pathways
8.0HLA-DQB1, HLA-DRB1, TNF, IL4, CD79A
327.9HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA
33
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
7.9TNF, TGFB1, IL4, IL5, CD79A
347.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, CSF1
357.8HLA-DRB1, TNF, ITGA6, IL4, IL5, CSF1
36
Show member pathways
7.6TNF, TGFB1, IL4, IL5, CSF1, CTGF
37
Show member pathways
7.6TNF, TGFB1, MIF, IL4, IL5, CSF1
38
Show member pathways
7.5TNF, TGFB1, ITGA6, ITGB4, IL4, IL5
397.4HLA-DRB1, TNF, TGFB1, IL4, IL5, CSF1
40
Show member pathways
7.1TNF, TGFB1, ITGA6, ITGB4, IL4, IL5
41
Show member pathways
6.8HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA, ITGA6
42
Show member pathways
6.6TNF, TGFB1, PRG2, ITGA6, ITGB4, IL4
43
Show member pathways
6.3IL5, HLA-DQB1, HLA-DRB1, TNF, TGFB1, CIITA

Compounds for genes affiliated with Ocular Cicatricial Pemphigoid

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Compounds related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1unicap449.9CD79A, IL5, RNASE3
2beclomethasone dipropionate449.7CSF1, IL5, RNASE3
3sodium cromoglycate449.6CD79A, IL5, RNASE3
4salbutamol44 50 28 24 1113.6CD79A, RNASE3, IL5, CSF1
5nedocromil sodium449.4IL4, CSF1, IL5, RNASE3
6praziquantel44 1110.4RNASE3, IL4, IL5, CD79A
7ltc4449.4IL5, RNASE3, CSF1, PRG2
8anti-fungal449.4RNASE3, CD79A, CSF1, IL5
9glatiramer acetate44 1110.3IL5, HLA-DRB1, CIITA, IL4
10pranlukast44 28 1110.9IL5, TNF, IL4, RNASE3
11methylcellulose448.9IL4, TGFB1, CSF1, IL5
12prednisolone44 28 1110.8RNASE3, TNF, CSF1, CD79A, IL5
13thyroxine44 249.7CIITA, TGFB1, IL5, IL4, CD79A
14polyinosinic-polycytidylic acid448.7TNF, CIITA, IL4, IL5, CSF1
15n-formylmethionyl-leucylphenylalanine448.6IL5, RNASE3, TNF, CSF1
16budesonide44 50 1110.6RNASE3, IL4, CSF1, IL5, TNF
17fluticasone propionate44 50 61 1111.6TNF, RNASE3, IL4, IL5, CSF1
18ivig448.6TNF, IL5, CSF1, CD79A, IL4
19herbimycin a44 619.5IL5, MIF, TNF, IL4, ITGA6
20fmlp448.4TNF, CSF1, RNASE3, PRG2, IL5
21methacholine44 50 1110.3PRG2, IL4, CD79A, IL5, TGFB1, RNASE3
22n acetylcysteine448.3CTGF, CD79A, CSF1, IL4, RNASE3, TNF
23allergens448.3HLA-DRB1, CIITA, RNASE3, PRG2, IL4, CD79A
24gm-csf44 289.3IL5, TNF, TGFB1, CSF1, IL4
25il 10448.2TNF, TGFB1, IL4, IL5, CSF1
26h2o2448.2IL5, MIF, CTGF, TNF, RNASE3, CSF1
27carbamazepine44 50 1110.2TNF, IL4, IL5, CD79A
28paraffin448.1IL5, TGFB1, DST, MIF, IL4, CD79A
29methotrexate50 44 1110.1TNF, CD79A, IL5, ITGA6, TGFB1, HLA-DRB1
30nitric oxide44 24 1110.0RNASE3, PRG2, CTGF, MIF, ITGB4, SERPINH1
31cysteine448.0CIITA, CTGF, IL4, MIF, PRG2, CSF1
32lactate448.0TNF, RNASE3, MIF, CD79A, CTGF, TGFB1
33sb 20358044 619.0TGFB1, MIF, IL4, IL5, CTGF, TNF
34tacrolimus44 50 119.9IL5, CD79A, IL4, TGFB1, TNF
35ly294002447.9TGFB1, IL4, CSF1, TNF, IL5, CTGF
36arginine447.8CD79A, CSF1, IL5, IL4, RNASE3, PRG2
37actinomycin d447.7TGFB1, CIITA, PRG2, IL4, CSF1, TNF
38rantes447.5IL4, TNF, TGFB1, CIITA, RNASE3, CSF1
39thymidine44 248.5CIITA, IL5, TNF, TGFB1, MIF, IL4
40indomethacin44 28 61 1110.4TGFB1, TNF, PRG2, IL4, IL5, CSF1
41serine447.4ITGB4, TGFB1, CTGF, TNF, CIITA, CSF1
42cycloheximide447.4DST, CSF1, IL4, TGFB1, TNF, IL5
43cyclosporin a44 28 619.3CTGF, TGFB1, TNF, SERPINH1, CIITA, CD79A
44oligonucleotide447.3PRG2, ITGA6, RNASE3, DST, SERPINH1, CIITA
45histamine44 28 249.2IL5, IL4, CD79A, CSF1, TNF, TGFB1
46pge2447.0TGFB1, CD79A, CSF1, IL5, IL4, MIF
47dexamethasone44 50 28 119.9TGFB1, TNF, CSF1, CIITA, RNASE3, MIF
48retinoic acid44 247.7ITGA6, TGFB1, IL5, TNF, ITGB4, RNASE3
49vegf446.7TNF, CD79A, CSF1, CTGF, IL5, IL4
50tyrosine446.6CTGF, CSF1, HLA-DRB1, CIITA, IL4, SERPINH1

GO Terms for genes affiliated with Ocular Cicatricial Pemphigoid

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Cellular components related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:0300569.8ITGB4, DST, ITGA6
2basal plasma membraneGO:0099259.8ITGB4, ITGA6, DST
3MHC class II protein complexGO:0426139.6HLA-DRB1, HLA-DQB1
4basement membraneGO:0056049.4ITGB4, ITGA6, DST
5cell surfaceGO:0099868.4TGFB1, CIITA, MIF, ITGB4, TNF
6external side of plasma membraneGO:0098978.3ITGA6, TNF, HLA-DRB1, IL4, CD79A
7extracellular regionGO:0055767.4TGFB1, RNASE3, TNF, PRG2, MIF, IL5
8extracellular spaceGO:0056157.3CTGF, TNF, TGFB1, SERPINH1, MIF, IL4
9plasma membraneGO:0058866.7CTGF, CD79A, CSF1, ITGB4, ITGA6, HLA-DQB1

Biological processes related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell motilityGO:04887010.1ITGB4, DST
2cell-matrix adhesionGO:00716010.1ITGA6, ITGB4, CTGF
3filopodium assemblyGO:04684710.1ITGA6, ITGB4
4positive regulation of phosphorylationGO:04232710.1ITGA6, MIF
5hemidesmosome assemblyGO:03158110.1ITGB4, ITGA6, DST
6positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, CIITA
7immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DRB1, HLA-DQB1
8humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DQB1, HLA-DRB1
9integrin-mediated signaling pathwayGO:0072299.8DST, ITGA6, ITGB4, CTGF
10positive regulation of cellular protein metabolic processGO:0322709.8CSF1, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.7HLA-DQB1, HLA-DRB1, CIITA
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7MIF, TNF
13positive regulation of B cell proliferationGO:0308909.7MIF, IL4, IL5
14positive regulation of podosome assemblyGO:0718039.7IL5, TNF
15positive regulation of collagen biosynthetic processGO:0329679.6TGFB1, CTGF
16positive regulation of osteoclast differentiationGO:0456729.5TNF, CSF1
17positive regulation of gene expressionGO:0106289.5TGFB1, CSF1, CTGF
18positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL4
19negative regulation of gene expressionGO:0106299.4CTGF, MIF, TNF
20cytokine-mediated signaling pathwayGO:0192219.4HLA-DQB1, HLA-DRB1, CIITA, IL5
21response to woundingGO:0096119.4TGFB1, DST, ITGB4, CTGF
22positive regulation of ERK1 and ERK2 cascadeGO:0703749.4CTGF, MIF, TNF
23positive regulation of cytokine secretionGO:0507159.4MIF, TNF
24positive regulation of protein complex assemblyGO:0313349.3TGFB1, TNF
25cellular response to organic cyclic compoundGO:0714079.2ITGA6, TGFB1, TNF
26positive regulation of MAP kinase activityGO:0434069.1MIF, TGFB1, TNF
27positive regulation of peptidyl-serine phosphorylationGO:0331389.1MIF, TGFB1, TNF
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1TNF, IL4, IL5
29osteoclast differentiationGO:0303169.0CSF1, TNF
30positive regulation of protein phosphorylationGO:0019349.0TNF, TGFB1, CTGF
31protein import into nucleus, translocationGO:0000608.9TNF, TGFB1
32negative regulation of transcription, DNA-templatedGO:0458928.5IL4, CIITA, TGFB1, TNF
33immune responseGO:0069558.4HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL4, IL5
34extracellular matrix organizationGO:0301988.4TNF, TGFB1, SERPINH1, DST, ITGA6, ITGB4
35positive regulation of transcription from RNA polymerase II promoterGO:0459448.4IL4, ITGA6, CIITA, TGFB1, TNF
36positive regulation of transcription, DNA-templatedGO:0458938.3TNF, TGFB1, CIITA, IL4, IL5
37inflammatory responseGO:0069548.3CSF1, IL5, MIF, CIITA, TGFB1, TNF

Molecular functions related to Ocular Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.5ITGA6, CTGF, DST
2MHC class II receptor activityGO:0323959.3HLA-DRB1, HLA-DQB1
3growth factor activityGO:0080838.5CTGF, CSF1, IL5, IL4, TGFB1
4cytokine activityGO:0051258.2CSF1, TNF, MIF, IL4, IL5
5protein bindingGO:0055156.6CTGF, IL5, IL4, ITGB4, DST, MIF

Products for genes affiliated with Ocular Cicatricial Pemphigoid

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  • Antibodies
  • Proteins
  • Lysates

Sources for Ocular Cicatricial Pemphigoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet