MCID: OCL010
MIFTS: 45

Ocular Hypotension malady

Eye diseases category

Summaries for Ocular Hypotension

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32MalaCards
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MalaCards: Ocular Hypotension, also known as decreased intraocular pressure, is related to glaucoma and ocular hypertension. An important gene associated with Ocular Hypotension is HTR2B (5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled), and among its related pathways are Proximal tubule bicarbonate reclamation and O2/CO2 exchange in erythrocytes. The compounds piribedil and s 16924 have been mentioned in the context of this disorder. Affiliated tissues include eye and brain, and related mouse phenotypes are skeleton and mortality/aging.

Aliases & Classifications for Ocular Hypotension

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

ocular hypotension 8 10 60
decreased intraocular pressure 8
hypotony of eye, unspecified 8
hypotony of eye unspecified 8
hypotony of eye nos 8
hypotony of eye 8


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Disease Ontology8 DOID:790
MeSH34 D015814
ICD9CM27 360.30, 360.3
ICD1025 H44.4

Related Diseases for Ocular Hypotension

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ocular Hypotension:



Diseases related to ocular hypotension

Clinical Features for Ocular Hypotension

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Drugs & Therapeutics for Ocular Hypotension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ocular Hypotension

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Anatomical Context for Ocular Hypotension

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32MalaCards
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MalaCards organs/tissues related to Ocular Hypotension:

32
Eye, Brain

Animal Models for Ocular Hypotension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ocular Hypotension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5PTGER2, MTM1, HTR2A, HTR2B, CA2
2MP:00107687.0ADRA2A, CA2, CA4, HTR2B, HTR1A, MTM1

Publications for Ocular Hypotension

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50PubMed
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Articles related to Ocular Hypotension:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. (21794845)
2011
2
Ocular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy. (21434594)
2010
3
Experimental model of ocular hypertension in the rat: study of the optic nerve capillaries and action of hypotensive drugs. (19797218)
2010
4
Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow. (19234340)
2009
5
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. (19445930)
2009
6
Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes. (18992242)
2009
7
Prolonged ocular hypotension: would ciliary tissue transplantation help. (19098698)
2009
8
Ocular hypotensive efficacy of brimonidine 0.15% as adjunctive therapy with latanoprost 0.005% in patients with open-angle glaucoma or ocular hypertension. (17565920)
2007
9
Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. (17238805)
2006
10
Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension. (16968567)
2006
11
Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study. (17056362)
2006
12
Fadolmidine-induced ocular hypotension in normotensive rabbits. (15720782)
2005
13
PD128,907 induces ocular hypotension in rabbits: involvement of D2/D3 dopamine receptors and brain natriuretic peptide. (15006155)
2004
14
Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. (14733708)
2003
15
Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. (12676887)
2003
16
Cystoid macular edema in the era of ocular hypotensive lipids. (11915838)
2002
17
Ocular hypotension induced by electroacupuncture. (12222760)
2002
18
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. (10882008)
2000
19
Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors. (10614682)
2000
20
8OH-DPAT-Induced ocular hypotension: sites and mechanisms of action. (10433858)
1999
21
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. (9851310)
1998
22
Lisuride acts at multiple sites to induce ocular hypotension and mydriasis. (9742290)
1998
23
Ocular hypotension induced by intravitreally injected C-type natriuretic peptide. (9533834)
1998
24
Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine. (9436152)
1997
25
Ocular hypotensive effect of topical ketanserin in timolol users. (9085107)
1997
26
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors. (8921215)
1996
27
Evaluation of IBMX-enhanced ocular hypotension after adrenergic agonists in the rabbit eye. (7542619)
1995
28
Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor. (8590276)
1995
29
Centrally mediated ocular hypotension: potential role of imidazoline receptors. (7677360)
1995
30
Ocular hypotension during short- and long-term hypocapnia. (19920601)
1994
31
Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. (7925603)
1994
32
Correlates of acute exercise-induced ocular hypotension. (7928182)
1994
33
Long-term visual outcome of ocular hypotension after thermosclerostomy. (8488912)
1993
34
PhXA34-induced ocular hypotension. (1463535)
1992
35
Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. (1349879)
1992
36
Soluble forms of isobutylmethylxanthine enhance the ocular hypotension induced by catecholamines. (1722476)
1991
37
Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles. (1712310)
1991
38
Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-1-isopropylester in the cynomolgus monkey. (2737263)
1989
39
Sustained decreases in systemic blood pressure do not cause ocular hypotension. (2710496)
1989
40
Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha. (3477218)
1987
41
Effect of pilocarpine in ocular hypotension. (3982788)
1985
42
Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. (6098513)
1984
43
Comparative study of aqueous and oily pilocarpine in the production of ocular hypotension. (7295614)
1981
44
Mature secondary cataracts and reversible ocular hypotension. (6992009)
1980
45
Effect of vehicle on pilocarpine-induced ocular hypotension. (735763)
1978
46
Ocular hypotension and massage of the eyeball. (4718630)
1973
47
The recovery phase after ocular hypotension induced by compression. (5542865)
1971
48
Dose response analysis of pilocarpine-induced ocular hypotension. (5478886)
1970
49
Ocular hypotension in a population survey. (5359506)
1969
50
Ocular hypotension with glycerol in cataract surgery. (5222692)
1966

Genetic Variations for Ocular Hypotension

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Expression for genes affiliated with Ocular Hypotension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Hypotension

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Pathways for genes affiliated with Ocular Hypotension

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Ocular Hypotension

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Ocular Hypotension according to GeneCards/GeneDecks:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1piribedil28 4410.8ADRA2A, HTR1A, HTR2B
2s 16924289.7HTR2A, HTR1A, HTR2B
3quipazine44 2810.7HTR1A, HTR2A, HTR2B
4sb 216641289.7HTR2B, HTR2A, HTR1A
5mesulergine28 4410.7HTR2B, HTR2A, HTR1A
6m-chlorophenylpiperazine449.7HTR2B, HTR1A, HTR2A
7sl65.0155289.7HTR2B, HTR2A, HTR1A
8mcpp449.7HTR2B, HTR1A, HTR2A
9ly344864289.7HTR2B, HTR2A, HTR1A
10ru 2496928 4410.7HTR2B, HTR1A, HTR2A
11brl-15572289.7HTR1A, HTR2B, HTR2A
12gr-127935289.7HTR2B, HTR1A, HTR2A
138-oh-dpat289.7HTR2A, HTR1A, HTR2B
145-ct289.6HTR2B, HTR2A, HTR1A
15pindolol44 28 1111.6HTR2B, HTR2A, HTR1A
16roxindole28 4410.6HTR2B, HTR1A, HTR2A
17Lurasidone119.6HTR2A, HTR1A, ADRA2A
185-ht289.6HTR2A, HTR2B, HTR1A
19spiperone28 4410.6HTR2B, HTR2A, HTR1A
20ritanserin28 4410.6HTR2A, HTR1A, HTR2B
21methiothepin44 2810.6HTR2B, HTR1A, HTR2A
22metergoline44 2810.6HTR2A, HTR1A, HTR2B
23methysergide44 28 1111.5HTR2A, HTR2B, HTR1A
24xanomeline28 4410.5HTR2A, HTR1A, HTR2B
25nefazodone44 49 1111.4ADRA2A, HTR2A, HTR1A
26spiroxatrine28 4410.4ADRA2A, HTR2A, HTR2B, HTR1A
27dihydroergotamine28 44 1111.4HTR1A, HTR2B, ADRA2A, HTR2A
28terguride28 4410.4HTR2A, HTR1A, HTR2B, ADRA2A
29trazodone44 28 1111.4ADRA2A, HTR2A, HTR1A, HTR2B
30ropinirole44 1110.4ADRA2A, HTR2B, HTR1A, HTR2A
31mianserin28 44 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
32lisuride28 44 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
33pergolide28 44 1111.4HTR2B, HTR2A, ADRA2A, HTR1A
34ergotamine28 44 1111.4HTR2B, HTR1A, ADRA2A, HTR2A
35pramipexole44 49 28 1112.4HTR2A, HTR2B, ADRA2A, HTR1A
36asenapine28 1110.4ADRA2A, HTR2B, HTR1A, HTR2A
37cabergoline28 44 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
38doxepin44 28 49 1112.4HTR2B, ADRA2A, HTR2A, HTR1A
39yohimbine44 28 2 1112.4ADRA2A, HTR2A, HTR1A, HTR2B
40apomorphine44 28 1111.4ADRA2A, HTR2A, HTR1A, HTR2B
41quetiapine44 49 28 11 2413.4HTR2B, HTR2A, HTR1A, ADRA2A
42bromocriptine28 44 1111.3HTR2B, HTR1A, ADRA2A, HTR2A
43fenfluramine28 44 1111.3HTR2A, HTR2B, HTR1A
44paliperidone44 1110.3HTR2A, ADRA2A, HTR1A
45olanzapine49 44 28 11 2413.3ADRA2A, HTR2A, HTR1A, HTR2B
46prazosin44 28 49 1112.2HTR2A, HTR1A, ADRA2A
47ketanserin28 4410.2HTR1A, HTR2A, HTR2B
48clozapine44 28 49 1112.1ADRA2A, HTR2A, HTR1A, HTR2B
49clomipramine44 49 1111.0HTR1A, HTR2B, HTR2A
50norepinephrine44 11 2410.7CA2, HTR2A, HTR2B, HTR1A, ADRA2A

GO Terms for genes affiliated with Ocular Hypotension

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16Gene Ontology
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Cellular components related to Ocular Hypotension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:0057919.6PTGDS, CA4
2basolateral plasma membraneGO:0163239.4CA2, CA4, ADRA2A
3integral to plasma membraneGO:0058878.3ADRA2A, PTGER2, HTR2A, HTR1A, HTR2B
4plasma membraneGO:0058867.5ADRA2A, PTGER2, MTM1, HTR2A, HTR1A, HTR2B

Biological processes related to Ocular Hypotension according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2A, HTR2B
2positive regulation of cytokine productionGO:0018199.9ADRA2A, HTR2B
3vasoconstrictionGO:0423109.9HTR1A, HTR2B
4regulation of hormone secretionGO:0468839.9HTR1A, HTR2A
5phosphatidylinositol 3-kinase cascadeGO:0140659.8HTR2A, HTR2B
6release of sequestered calcium ion into cytosolGO:0512099.7HTR2B, HTR2A
7one-carbon metabolic processGO:0067309.7CA4, CA2
8positive regulation of MAP kinase activityGO:0434069.6ADRA2A, HTR2A, HTR2B
9serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR1A, HTR2B
10regulation of behaviorGO:0507959.6HTR2B, HTR1A, HTR2A
11bicarbonate transportGO:0157019.5CA4, CA2
12G-protein coupled receptor signaling pathwayGO:0071869.3ADRA2A, PTGER2, HTR1A, HTR2B
13positive regulation of cell proliferationGO:0082849.1HTR2B, HTR1A, HTR2A, ADRA2A
14small molecule metabolic processGO:0442818.3CA4, MTM1, PTGDS, ADRA2A, CA2

Molecular functions related to Ocular Hypotension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:0040899.8CA4, CA2
2serotonin bindingGO:0513789.6HTR2A, HTR2B
3G-protein alpha-subunit bindingGO:0019659.4HTR2A, HTR2B
4serotonin receptor activityGO:0049939.3HTR2A, HTR1A, HTR2B

Products for genes affiliated with Ocular Hypotension

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Sources for Ocular Hypotension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet