MCID: OCL010
MIFTS: 40

Ocular Hypotension malady

Eye category

Summaries for Ocular Hypotension

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Ocular Hypotension, also known as decreased intraocular pressure, is related to ocular hypertension and cystoid macular edema. An important gene associated with Ocular Hypotension is HTR2B (5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled), and among its related pathways are Proximal tubule bicarbonate reclamation and O2/CO2 exchange in erythrocytes. The compounds piribedil and s 16924 have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and mortality/aging.

Aliases & Classifications for Ocular Hypotension

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

ocular hypotension 8 10 61
decreased intraocular pressure 8
hypotony of eye, unspecified 8
hypotony of eye unspecified 8
hypotony of eye nos 8
hypotony of eye 8


External Ids:

Disease Ontology8 DOID:790
MeSH35 D015814
ICD9CM27 360.30, 360.3
ICD1025 H44.4

Related Diseases for Ocular Hypotension

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Ocular Hypotension:



Diseases related to ocular hypotension

Clinical Features for Ocular Hypotension

Drugs & Therapeutics for Ocular Hypotension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Ocular Hypotension

Drug clinical trials:

Search ClinicalTrials for Ocular Hypotension

Search NIH Clinical Center for Ocular Hypotension

Search CenterWatch for Ocular Hypotension

Genetic Tests for Ocular Hypotension

Anatomical Context for Ocular Hypotension

Animal Models for Ocular Hypotension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ocular Hypotension:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5CA2, HTR2B, HTR2A, MTM1, PTGER2
2MP:00107687.0CA2, CA4, HTR2B, HTR1A, MTM1, PTGER2

Publications for Ocular Hypotension

Sources:
51PubMed
See all sources

Articles related to Ocular Hypotension:

(show all 43)
idTitleAuthorsYear
1
Ocular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy. (21434594)
2010
2
Morphine-induced ocular hypotension is modulated by nitric oxide and carbon monoxide: role of mu3 receptors. (20148660)
2010
3
Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow. (19234340)
2009
4
Prolonged ocular hypotension: would ciliary tissue transplantation help. (19098698)
2009
5
A review of ocular manifestations in intracranial hypotension. (18004970)
2007
6
Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. (17238805)
2006
7
Fadolmidine-induced ocular hypotension in normotensive rabbits. (15720782)
2005
8
PD128,907 induces ocular hypotension in rabbits: involvement of D2/D3 dopamine receptors and brain natriuretic peptide. (15006155)
2004
9
Ocular hypotension induced by electroacupuncture. (12222760)
2002
10
Mechanism of exercise-induced ocular hypotension. (10102302)
1999
11
8OH-DPAT-Induced ocular hypotension: sites and mechanisms of action. (10433858)
1999
12
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. (9851310)
1998
13
Lisuride acts at multiple sites to induce ocular hypotension and mydriasis. (9742290)
1998
14
Ocular hypotension induced by intravitreally injected C-type natriuretic peptide. (9533834)
1998
15
Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine. (9436152)
1997
16
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors. (8921215)
1996
17
Evaluation of IBMX-enhanced ocular hypotension after adrenergic agonists in the rabbit eye. (7542619)
1995
18
Centrally mediated ocular hypotension: potential role of imidazoline receptors. (7677360)
1995
19
Ocular hypotension during short- and long-term hypocapnia. (19920601)
1994
20
Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. (7925603)
1994
21
Correlates of acute exercise-induced ocular hypotension. (7928182)
1994
22
Long-term visual outcome of ocular hypotension after thermosclerostomy. (8488912)
1993
23
PhXA34-induced ocular hypotension. (1463535)
1992
24
Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. (1349879)
1992
25
Reattachment of the detached ciliary body with suturing for treatment of contusional ocular hypotension. (1896179)
1991
26
Soluble forms of isobutylmethylxanthine enhance the ocular hypotension induced by catecholamines. (1722476)
1991
27
Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles. (1712310)
1991
28
Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-1-isopropylester in the cynomolgus monkey. (2737263)
1989
29
Sustained decreases in systemic blood pressure do not cause ocular hypotension. (2710496)
1989
30
Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha. (3477218)
1987
31
Effect of pilocarpine in ocular hypotension. (3982788)
1985
32
Inflow and outflow relations after intraocular fluid-Healon exchange in a case of chronic ocular hypotension. (4086174)
1985
33
Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin. (2857689)
1985
34
Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. (6098513)
1984
35
Comparative study of aqueous and oily pilocarpine in the production of ocular hypotension. (7295614)
1981
36
Mature secondary cataracts and reversible ocular hypotension. (6992009)
1980
37
Effect of vehicle on pilocarpine-induced ocular hypotension. (735763)
1978
38
Possibility of isoproterenol therapy with soft contact lenses: ocular hypotension without systemic effects. (962259)
1976
39
Ocular hypotension and massage of the eyeball. (4718630)
1973
40
The recovery phase after ocular hypotension induced by compression. (5542865)
1971
41
Dose response analysis of pilocarpine-induced ocular hypotension. (5478886)
1970
42
Ocular hypotension in a population survey. (5359506)
1969
43
Ocular hypotension with glycerol in cataract surgery. (5222692)
1966

Genetic Variations for Ocular Hypotension

Expression for genes affiliated with Ocular Hypotension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ocular Hypotension

Search GEO for disease gene expression data for Ocular Hypotension.

Pathways for genes affiliated with Ocular Hypotension

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Ocular Hypotension

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Ocular Hypotension according to GeneCards/GeneDecks:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1piribedil29 4510.8ADRA2A, HTR1A, HTR2B
2s 16924299.7HTR2A, HTR1A, HTR2B
3quipazine45 2910.7HTR1A, HTR2A, HTR2B
4sb 216641299.7HTR2B, HTR2A, HTR1A
5mesulergine29 4510.7HTR2B, HTR2A, HTR1A
6m-chlorophenylpiperazine459.7HTR2B, HTR1A, HTR2A
7sl65.0155299.7HTR2B, HTR2A, HTR1A
8mcpp459.7HTR2B, HTR1A, HTR2A
9ly344864299.7HTR2B, HTR2A, HTR1A
10ru 2496929 4510.7HTR2B, HTR1A, HTR2A
11brl-15572299.7HTR1A, HTR2B, HTR2A
12gr-127935299.7HTR2B, HTR1A, HTR2A
138-oh-dpat299.7HTR2A, HTR1A, HTR2B
145-ct299.6HTR2B, HTR2A, HTR1A
15pindolol45 29 1111.6HTR2B, HTR2A, HTR1A
16roxindole29 4510.6HTR2B, HTR1A, HTR2A
17Lurasidone119.6HTR2A, HTR1A, ADRA2A
185-ht299.6HTR2A, HTR2B, HTR1A
19spiperone29 4510.6HTR2B, HTR2A, HTR1A
20ritanserin29 4510.6HTR2A, HTR1A, HTR2B
21methiothepin45 2910.6HTR2B, HTR1A, HTR2A
22metergoline45 2910.6HTR2A, HTR1A, HTR2B
23methysergide45 29 1111.5HTR2A, HTR2B, HTR1A
24xanomeline29 4510.5HTR2A, HTR1A, HTR2B
25nefazodone45 50 1111.4ADRA2A, HTR2A, HTR1A
26spiroxatrine29 4510.4ADRA2A, HTR2A, HTR2B, HTR1A
27dihydroergotamine29 45 1111.4HTR1A, HTR2B, ADRA2A, HTR2A
28terguride29 4510.4HTR2A, HTR1A, HTR2B, ADRA2A
29trazodone45 29 1111.4ADRA2A, HTR2A, HTR1A, HTR2B
30ropinirole45 1110.4ADRA2A, HTR2B, HTR1A, HTR2A
31mianserin29 45 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
32lisuride29 45 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
33pergolide29 45 1111.4HTR2B, HTR2A, ADRA2A, HTR1A
34ergotamine29 45 1111.4HTR2B, HTR1A, ADRA2A, HTR2A
35pramipexole45 50 29 1112.4HTR2A, HTR2B, ADRA2A, HTR1A
36asenapine29 1110.4ADRA2A, HTR2B, HTR1A, HTR2A
37cabergoline29 45 1111.4HTR2B, HTR1A, HTR2A, ADRA2A
38doxepin45 29 50 1112.4HTR2B, ADRA2A, HTR2A, HTR1A
39yohimbine45 29 2 1112.4ADRA2A, HTR2A, HTR1A, HTR2B
40apomorphine45 29 1111.4ADRA2A, HTR2A, HTR1A, HTR2B
41quetiapine45 50 29 11 2413.4HTR2B, HTR2A, HTR1A, ADRA2A
42bromocriptine29 45 1111.3HTR2B, HTR1A, ADRA2A, HTR2A
43fenfluramine29 45 1111.3HTR2A, HTR2B, HTR1A
44paliperidone45 1110.3HTR2A, ADRA2A, HTR1A
45olanzapine50 45 29 11 2413.3ADRA2A, HTR2A, HTR1A, HTR2B
46prazosin45 29 50 1112.2HTR2A, HTR1A, ADRA2A
47ketanserin29 4510.2HTR1A, HTR2A, HTR2B
48clozapine45 29 50 1112.1ADRA2A, HTR2A, HTR1A, HTR2B
49clomipramine45 50 1111.0HTR1A, HTR2B, HTR2A
50norepinephrine45 11 2410.7CA2, HTR2A, HTR2B, HTR1A, ADRA2A

GO Terms for genes affiliated with Ocular Hypotension

Sources:
16Gene Ontology
See all sources

Cellular components related to Ocular Hypotension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:0057919.6CA4, PTGDS
2basolateral plasma membraneGO:0163239.4CA4, ADRA2A, CA2
3integral to plasma membraneGO:0058878.3ADRA2A, PTGER2, HTR2A, HTR1A, HTR2B
4plasma membraneGO:0058867.5CA2, CA4, HTR2B, HTR1A, HTR2A, MTM1

Biological processes related to Ocular Hypotension according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2A, HTR2B
2positive regulation of cytokine productionGO:0018199.9HTR2B, ADRA2A
3vasoconstrictionGO:0423109.9HTR2B, HTR1A
4regulation of hormone secretionGO:0468839.9HTR2A, HTR1A
5phosphatidylinositol 3-kinase cascadeGO:0140659.8HTR2B, HTR2A
6release of sequestered calcium ion into cytosolGO:0512099.7HTR2A, HTR2B
7bicarbonate transportGO:0157019.7CA4, CA2
8positive regulation of MAP kinase activityGO:0434069.6HTR2B, ADRA2A, HTR2A
9serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR2B, HTR1A
10regulation of behaviorGO:0507959.6HTR1A, HTR2B, HTR2A
11one-carbon metabolic processGO:0067309.5CA4, CA2
12G-protein coupled receptor signaling pathwayGO:0071869.3HTR2B, HTR1A, PTGER2, ADRA2A
13positive regulation of cell proliferationGO:0082849.1HTR2B, HTR1A, ADRA2A, HTR2A
14small molecule metabolic processGO:0442818.3ADRA2A, PTGDS, CA2, CA4, MTM1

Molecular functions related to Ocular Hypotension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:0040899.8CA4, CA2
2serotonin bindingGO:0513789.6HTR2A, HTR2B
3G-protein alpha-subunit bindingGO:0019659.4HTR2A, HTR2B
4serotonin receptor activityGO:0049939.3HTR2A, HTR1A, HTR2B

Products for genes affiliated with Ocular Hypotension

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Hypotension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet