MCID: OCL010
MIFTS: 29

Ocular Hypotension malady

Eye diseases category

Summaries for Ocular Hypotension

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34MalaCards
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MalaCards: Ocular Hypotension, also known as decreased intraocular pressure, is related to ocular hypertension and hypertension. An important gene associated with Ocular Hypotension is HTR2B (5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled). The compound calcium have been mentioned in the context of this disorder. Affiliated tissues include eye and brain, and related mouse phenotype mortality/aging.

Aliases & Classifications for Ocular Hypotension

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

ocular hypotension 9 11 63
decreased intraocular pressure 9
hypotony of eye, unspecified 9
hypotony of eye unspecified 9
hypotony of eye nos 9
hypotony of eye 9


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Disease Ontology9 DOID:790
ICD9CM28 360.3, 360.30
MeSH36 D015814
ICD1026 H44.4

Related Diseases for Ocular Hypotension

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Ocular Hypotension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension10.4
2hypertension10.4
3glaucoma10.4
4open-angle glaucoma10.3
5cystoid macular edema10.2
6cataract10.2
7primary eye hypotony10.2
8primary open angle glaucoma10.0
9diabetic macular edema10.0
10leprosy10.0
11uveitis10.0
12anterior uveitis10.0

Graphical network of diseases related to Ocular Hypotension:



Diseases related to ocular hypotension

Symptoms for Ocular Hypotension

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Drugs & Therapeutics for Ocular Hypotension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Ocular Hypotension

Drug clinical trials:

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Search NIH Clinical Center for Ocular Hypotension

Search CenterWatch for Ocular Hypotension

Genetic Tests for Ocular Hypotension

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Anatomical Context for Ocular Hypotension

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34MalaCards
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MalaCards organs/tissues related to Ocular Hypotension:

34
Eye, Brain

Animal Models for Ocular Hypotension or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Ocular Hypotension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.1HTR2B, PTGDS

Publications for Ocular Hypotension

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53PubMed
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Articles related to Ocular Hypotension:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Impact of ocular hypotensive lipids on clinically significant diabetic macular edema. (22267460)
2012
2
Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. (21794845)
2011
3
Ocular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy. (21434594)
2010
4
Morphine-induced ocular hypotension is modulated by nitric oxide and carbon monoxide: role of mu3 receptors. (20148660)
2010
5
Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action. (20426763)
2010
6
Ocular hypotensive efficacy and safety of travoprost 0.004% in inadequately controlled primary open-angle glaucoma or ocular hypertension: short-term, multicenter, prospective study. (19210139)
2009
7
Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow. (19234340)
2009
8
Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes. (18992242)
2009
9
Use of ocular hypotensive prostaglandin analogues in patients with uveitis: does their use increase anterior uveitis and cystoid macular oedema? (18460537)
2008
10
Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. (17238805)
2006
11
Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension. (16968567)
2006
12
Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study. (17056362)
2006
13
Fadolmidine-induced ocular hypotension in normotensive rabbits. (15720782)
2005
14
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. (15216404)
2004
15
Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. (15037111)
2004
16
Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. (14733708)
2003
17
New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. (14646172)
2003
18
Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. (12676887)
2003
19
Cystoid macular edema in the era of ocular hypotensive lipids. (11915838)
2002
20
Cystoid macular edema associated with ocular hypotensive lipids. (11860980)
2002
21
Mechanism of exercise-induced ocular hypotension. (10102302)
1999
22
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. (9851310)
1998
23
Lisuride acts at multiple sites to induce ocular hypotension and mydriasis. (9742290)
1998
24
Ocular hypotension induced by intravitreally injected C-type natriuretic peptide. (9533834)
1998
25
Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine. (9436152)
1997
26
Ocular hypotensive effect of topical ketanserin in timolol users. (9085107)
1997
27
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors. (8921215)
1996
28
Evaluation of IBMX-enhanced ocular hypotension after adrenergic agonists in the rabbit eye. (7542619)
1995
29
Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor. (8590276)
1995
30
Centrally mediated ocular hypotension: potential role of imidazoline receptors. (7677360)
1995
31
Ocular hypotension during short- and long-term hypocapnia. (19920601)
1994
32
Long-term visual outcome of ocular hypotension after thermosclerostomy. (8488912)
1993
33
PhXA34-induced ocular hypotension. (1463535)
1992
34
Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. (1349879)
1992
35
Reattachment of the detached ciliary body with suturing for treatment of contusional ocular hypotension. (1896179)
1991
36
Soluble forms of isobutylmethylxanthine enhance the ocular hypotension induced by catecholamines. (1722476)
1991
37
The ocular hypotensive effect of the topical carbonic anhydrase inhibitor L-671,152 in glaucomatous monkeys. (2322152)
1990
38
Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-1-isopropylester in the cynomolgus monkey. (2737263)
1989
39
Sustained decreases in systemic blood pressure do not cause ocular hypotension. (2710496)
1989
40
Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha. (3477218)
1987
41
Effect of pilocarpine in ocular hypotension. (3982788)
1985
42
Inflow and outflow relations after intraocular fluid-Healon exchange in a case of chronic ocular hypotension. (4086174)
1985
43
Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. (6098513)
1984
44
Mature secondary cataracts and reversible ocular hypotension. (6992009)
1980
45
Effect of vehicle on pilocarpine-induced ocular hypotension. (735763)
1978
46
Possibility of isoproterenol therapy with soft contact lenses: ocular hypotension without systemic effects. (962259)
1976
47
The recovery phase after ocular hypotension induced by compression. (5542865)
1971
48
Dose response analysis of pilocarpine-induced ocular hypotension. (5478886)
1970
49
Ocular hypotension in a population survey. (5359506)
1969
50
Ocular hypotension with glycerol in cataract surgery. (5222692)
1966

Variations for Ocular Hypotension

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Expression for genes affiliated with Ocular Hypotension

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Hypotension

Search GEO for disease gene expression data for Ocular Hypotension.

Pathways for genes affiliated with Ocular Hypotension

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Compounds for genes affiliated with Ocular Hypotension

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Ocular Hypotension according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium46 52 25 1212.1HTR2B, PTGDS

GO Terms for genes affiliated with Ocular Hypotension

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Products for genes affiliated with Ocular Hypotension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Hypotension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet