MCID: OCL022
MIFTS: 37

Ocular Melanoma malady

Rare diseases category
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Summaries for Ocular Melanoma

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Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Ocular melanoma (om) is a cancer in pigment-producing cells of the eye called melanocytes.   melanocytes are cells that produce the pigment melanin that colors the skin, hair, and eyes, as well as forms moles.  there are four tissues in the eye in which melanoma can develop: the uveal tract (uvea); conjunctiva; eyelid; and orbit.  the uvea - the middle layer within the eye  - is divided into three main parts: the iris, ciliary body, and choroid.  uveal melanoma, also called intraocular melanoma, is the most common ocular melanoma. conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. eyelid and primary orbital melanoma are the least common variants. last updated: 1/14/2013

MalaCards: Ocular Melanoma, also known as malignant melanoma of eye, is related to melanoma and breast cancer. An important gene associated with Ocular Melanoma is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)). The compounds ibmx and mspi have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and liver, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Ocular Melanoma

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43NIH Rare Diseases, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

ocular melanoma 43 45
malignant melanoma of eye 62


Related Diseases for Ocular Melanoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ocular Melanoma:



Diseases related to ocular melanoma

Symptoms for Ocular Melanoma

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Drugs & Therapeutics for Ocular Melanoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Ocular Melanoma

Search NIH Clinical Center for Ocular Melanoma

Genetic Tests for Ocular Melanoma

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Anatomical Context for Ocular Melanoma

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33MalaCards
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MalaCards organs/tissues related to Ocular Melanoma:

33
Eye, Skin, Liver, Testes, Pancreas, Lymph node, B cells, T cells, Nk cells, Breast, Bone marrow, Kidney, Smooth muscle, Bone, Endothelial

Animal Models for Ocular Melanoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ocular Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1BAP1, BRCA2, MC1R
2MP:00053767.3GAS6, HMBS, BAP1, BRCA2, CIITA

Publications for Ocular Melanoma

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52PubMed
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Articles related to Ocular Melanoma:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
SECONDARY NEUTRON DOSES IN PROTON THERAPY TREATMENTS OF OCULAR MELANOMA AND CRANIOPHARYNGIOMA. (24222710)
2013
2
Ocular immune privilege and ocular melanoma: parallel universes or immunological plagiarism? (22707951)
2012
3
Ocular melanoma and mammary mucinous carcinoma in an African lion. (23009723)
2012
4
Ocular melanoma. (23960984)
2012
5
Outcome of patients following hepatic resection for metastatic cutaneous and ocular melanoma. (21057964)
2011
6
Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. (19661223)
2010
7
Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma. (20221901)
2010
8
Ocular melanoma presenting as a case of panophthalmitis in a 78-year-old Nigerian woman (masquerade syndrome): an uncommon finding in Benin City, Nigeria. (17760933)
2007
9
Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma. (17640369)
2007
10
The significant threat of patients with cutaneous malignant melanoma to develop ocular melanoma. (15654168)
2005
11
Metastatic ocular melanoma to the kidney 20 years after initial diagnosis. (16140107)
2005
12
Trends in the incidence of ocular melanoma in the United States, 1974-1998. (15049325)
2004
13
Diagnosis and follow up of primary ocular melanoma by radioimmunoscintigraphy. (17415830)
2004
14
Regional treatment options for patients with ocular melanoma metastatic to the liver. (14993024)
2004
15
Ten-year follow-up of fellow eyes of patients enrolled in Collaborative Ocular Melanoma Study randomized trials: COMS report no. 22. (15121376)
2004
16
Interferon alpha 2b decreases hepatic micrometastasis in a murine model of ocular melanoma by activation of intrinsic hepatic natural killer cells. (15223777)
2004
17
Ocular melanoma: a review and the relationship to cutaneous melanoma. (12925397)
2003
18
Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2. (12373596)
2002
19
Collaborative ocular melanoma study (COMS) randomized trial of I-125 brachytherapy for medium choroidal melanoma. I. Visual acuity after 3 years COMS report no. 16. (11158813)
2001
20
Abnormalities of the transforming growth factor-beta pathway in ocular melanoma. (11113869)
2000
21
Echography (ultrasound) procedures for the Collaborative Ocular Melanoma Study (COMS), Report no. 12, Part I. (10847038)
1999
22
Atypical primary ocular melanoma in cats. (11397253)
1999
23
Depletion of NK cell activity results in growth of hepatic micrometastases in a murine ocular melanoma model. (10520219)
1999
24
Quality of life assessment in the collaborative ocular melanoma study: design and methods. COMS-QOLS Report No. 1. COMS Quality of Life Study Group. (10384680)
1999
25
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease. (9247253)
1997
26
Clear cell differentiation in choroidal melanoma. COMS report no. 8. Collaborative Ocular Melanoma Study Group. (9230830)
1997
27
Mortality in patients with small choroidal melanoma. COMS report no. 4. The Collaborative Ocular Melanoma Study Group. (9230829)
1997
28
Treatment of ocular melanoma metastatic to the liver by hepatic arterial chemotherapy. (9215829)
1997
29
The clinical role of immunoscintigraphy for the detection of ocular melanoma. (9050338)
1996
30
Multidrug resistance in ocular melanoma. (8976731)
1996
31
Risk of ocular melanoma in relation to cutaneous and iris naevi. (7860135)
1995
32
Effects of gamma radiation on the OM431 human ocular melanoma cell line. (7641843)
1995
33
Risks of second primary malignancy in patients with cutaneous and ocular melanoma in Denmark, 1943-1989. (7790110)
1995
34
Selective boron accumulation in human ocular melanoma vs surrounding eye components after 10B1-p-boronophenylalanine administration. Prerequisite for clinical trial of neutron-capture therapy. (7919964)
1994
35
Gamma Knife radiosurgery in the treatment of ocular melanoma. (8115754)
1993
36
Ocular melanoma: an experimental model in New Zealand white rabbits. (8400856)
1993
37
The clinical status of immunoscintigraphy with monoclonal antibodies in ocular melanoma. (1856514)
1991
38
The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group. (1700611)
1990
39
Ocular melanoma in families with dysplastic nevus syndrome. (2254470)
1990
40
Failure of preenucleation radiation to decrease uveal melanoma mortality. The Collaborative Ocular melanoma Study Steering Committee. (2929718)
1989
41
Ocular melanoma. (2804036)
1989
42
Place of birth and incidence of ocular melanoma in the United States. (3196415)
1988
43
Visualization of ocular melanoma with N-isopropyl-p-[123I]-iodoamphetamine. (3404259)
1988
44
Radioimmunoscintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibody fragments. (2822079)
1987
45
Angioimmunoblastic lymphadenopathy with malignant transformation during long-term remission of ocular melanoma. (3826109)
1987
46
Is the Collaborative Ocular Melanoma Study worthwhile? (3789966)
1986
47
Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives. (6840126)
1983
48
Survival in metastatic ocular melanoma. (6190546)
1983
49
Noncontact detection of ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine: first clinical results. (7173627)
1982
50
The 32P test in the diagnosis of ocular melanoma. I. An unnecessary invasive test. (7414507)
1980

Variations for Ocular Melanoma

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Expression for genes affiliated with Ocular Melanoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Melanoma

Search GEO for disease gene expression data for Ocular Melanoma.

Pathways for genes affiliated with Ocular Melanoma

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Compounds for genes affiliated with Ocular Melanoma

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Ocular Melanoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ibmx45 61 2911.4MC1R, CIITA
2mspi459.4BRCA2, HMBS
3h2o2459.2BRCA2, MC1R, SERPINF1
4phosphatidylinositol459.0GAS6, BRCA2, CIITA
5cycloheximide458.9BRCA2, CIITA, HMBS
6nitric oxide45 24 1110.6CIITA, SERPINF1, HMBS
7calcium45 51 24 1111.5CIITA, SERPINF1, MC1R, GAS6
8serine458.5MC1R, CIITA, HMBS, SERPINF1

GO Terms for genes affiliated with Ocular Melanoma

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16Gene Ontology
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Biological processes related to Ocular Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.5SERPINF1, CIITA
2negative regulation of tumor necrosis factor productionGO:0327209.4GAS6, MC1R
3positive regulation of protein kinase B signalingGO:0518979.2GAS6, MC1R

Products for genes affiliated with Ocular Melanoma

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Sources for Ocular Melanoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet