MCID: OCL022
MIFTS: 38

Ocular Melanoma malady

Summaries for Ocular Melanoma

Sources:
43NIH Rare Diseases, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Ocular melanoma (om) is a cancer in pigment-producing cells of the eye called melanocytes.   melanocytes are cells that produce the pigment melanin that colors the skin, hair, and eyes, as well as forms moles.  there are four tissues in the eye in which melanoma can develop: the uveal tract (uvea); conjunctiva; eyelid; and orbit.  the uvea - the middle layer within the eye  - is divided into three main parts: the iris, ciliary body, and choroid.  uveal melanoma, also called intraocular melanoma, is the most common ocular melanoma. conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. eyelid and primary orbital melanoma are the least common variants. last updated: 1/14/2013

MalaCards: Ocular Melanoma, also known as malignant melanoma of eye, is related to amelanotic melanoma and n syndrome. An important gene associated with Ocular Melanoma is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)), and among its related pathways is Platelet degranulation . The compounds phosphatidylserine and matrigel have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and smooth muscle, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Ocular Melanoma

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

ocular melanoma 43 45
malignant melanoma of eye 61


Related Diseases for Ocular Melanoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ocular Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1amelanotic melanoma10.1
2n syndrome10.1
3malignant peritoneal mesothelioma10.0
4smooth muscle tumor10.0
5dysplastic nevus syndrome10.0
6retinal melanoma10.0
7panophthalmitis10.0
8acute leukemia10.0
9cutaneous malignant melanoma10.0
10syncope10.0
11hepatitis10.0MAGEA1
12thyroiditis10.0CIITA
13medulloblastoma10.0BRCA2
14leiomyoma10.0CYR61
15myeloid leukemia10.0AXL
16cholangiocarcinoma10.0NRAS, MAGEA3
17pancreatitis10.0NRAS, BRCA2
18bile duct carcinoma10.0BRCA2, MAGEA3
19endometriosis10.0CYR61
20arthritis10.0CIITA, PLG
21mesangial proliferative glomerulonephritis10.0AXL, GAS6
22proliferative diabetic retinopathy10.0SERPINF1
23myeloma10.0CIITA, MAGEA1
24sarcoma10.0BRCA2, NRAS, MAGEA3, MAGEA1
25glioblastoma multiforme10.0PLG, MAGEA3, S100A6
26ischemia10.0PLG, CIITA, CYR61
27retinal vascular disease10.0PLG, SERPINF1
28rheumatoid arthritis10.0CIITA, PLG, S100A6
29astrocytoma10.0S100A6, S100A11, CIITA, MAGEA3
30papillary carcinoma10.0S100A6, AXL, BRCA2
31colorectal cancer10.0S100A11, NRAS, MAGEA3, MAGEA1, BRCA2
32thyroid cancer10.0GAS6, AXL, S100A6
33diabetic nephropathy10.0AXL, PLG, GAS6, SERPINF1
34multiple sclerosis10.0CIITA, MC1R
35corneal neovascularization10.0PLG, SERPINF1
36pancreatic cancer10.0S100A6, PLG, BRCA2, NRAS
37endometrial carcinoma10.0CYR61, NRAS, PLG, S100A6, BRCA2
38non-small cell lung carcinoma10.0PLG, MAGEA3, SERPINF1, MAGEA1, CD63, AXL
39ovarian cancer10.0BRCA2, MAGEA3, MAGEA1, SERPINF1, S100A6, PLG
40malignant glioma10.0HMBS, CIITA, PLG, SERPINF1, CYR61
41intraocular melanoma10.0MAGEA3, MAGEA1, CYR61, NRAS, MC1R, PLG
42hepatocellular carcinoma10.0SERPINF1, CIITA, MAGEA3, MAGEA1, CD63, CYR61
43atherosclerosis10.0SERPINF1, GAS6, CIITA, CYR61, PLG
44stomach cancer10.0CYR61, BRCA2, S100A6, AXL, MAGEA1, MAGEA3
45adenoma10.0S100A6, AXL, NRAS
46adenocarcinoma10.0HMBS, CYR61, MAGEA1, MAGEA3, S100A6, PLG
47prostate cancer10.0BRCA2, MC1R, CYR61, SERPINF1, CD63, GAS6
48squamous cell carcinoma10.0S100A6, MC1R, CYR61, MAGEA1, SERPINF1, MAGEA3
49lung cancer10.0CIITA, BRCA2, CYR61, MAGEA1, CD63, AXL
50leukemia10.0SERPINF1, HMBS, PLG, BRCA2, AXL, GAS6

Graphical network of the top 20 diseases related to Ocular Melanoma:



Diseases related to ocular melanoma

Clinical Features for Ocular Melanoma

Drugs & Therapeutics for Ocular Melanoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ocular Melanoma

Drug clinical trials:

Search ClinicalTrials for Ocular Melanoma

Search NIH Clinical Center for Ocular Melanoma

Search CenterWatch for Ocular Melanoma

Genetic Tests for Ocular Melanoma

Anatomical Context for Ocular Melanoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Ocular Melanoma:

33
Bone marrow, Lymph node, Smooth muscle, Kidney, Liver, Pancreas, Breast, Skin, Nk cells, T cells, B cells, Endothelial

Animal Models for Ocular Melanoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ocular Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.3SERPINF1, PLG, CYR61, AXL, BAP1, ANXA6

Publications for Ocular Melanoma

Sources:
51PubMed
See all sources

Articles related to Ocular Melanoma:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
The Collaborative Ocular Melanoma Study, mortality by therapeutic approach, age and tumor size. (24069782)
2013
2
Solitary secondary malignant melanoma of clavicle two years after enuclation for ocular melanoma. (23424696)
2013
3
Ocular melanoma. (23960984)
2012
4
Ocular melanoma metastasis to the cervical spine. (22245271)
2012
5
Phacomatosis pigmentovascularis of cesioflammea type in 7 patients: combination of ocular pigmentation (melanocytosis or melanosis) and nevus flammeus with risk for melanoma. (21670341)
2011
6
Ocular melanoma metastatic to the pancreas after a 28-year disease-free interval. (19744448)
2010
7
Choroidal melanoma in a patient with congenital bilateral chorioretinal coloboma: a case report of an extremely rare association of ocular comorbities. (21225135)
2010
8
Hepatic artery chemoembolization in patients with ocular melanoma metastatic to the liver: response, survival, and prognostic factors. (19935383)
2010
9
Histopathologic characteristics of choroidal melanoma in eyes enucleated after iodine 125 brachytherapy in the collaborative ocular melanoma study. (18268211)
2008
10
Comparison of survival among eligible patients not enrolled versus enrolled in the Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma. (17896305)
2007
11
Metastatic ocular melanoma to the kidney 20 years after initial diagnosis. (16140107)
2005
12
Monte Carlo simulation of a protontherapy platform devoted to ocular melanoma. (15895573)
2005
13
Trends in the incidence of ocular melanoma in the United States, 1974-1998. (15049325)
2004
14
Regional treatment options for patients with ocular melanoma metastatic to the liver. (14993024)
2004
15
Ten-year follow-up of fellow eyes of patients enrolled in Collaborative Ocular Melanoma Study randomized trials: COMS report no. 22. (15121376)
2004
16
Interferon alpha 2b decreases hepatic micrometastasis in a murine model of ocular melanoma by activation of intrinsic hepatic natural killer cells. (15223777)
2004
17
Solitary ovarian metastasis from ocular melanoma. (15295396)
2004
18
Ocular melanoma and cutaneous melanoma. (12569586)
2003
19
Trends in the incidence of ocular melanoma in the United States, 1974-1998. (12814204)
2003
20
Treatment of pediatric ocular melanoma with high-dose interleukin-2 and thalidomide. (12218599)
2002
21
Cause-specific mortality coding. methods in the collaborative ocular melanoma study coms report no. 14. (11384789)
2001
22
Atypical primary ocular melanoma in cats. (11397253)
1999
23
Ocular melanoma. (10349544)
1999
24
Treatment of ocular melanoma metastatic to the liver by hepatic arterial chemotherapy. (9215829)
1997
25
Expression of MAGE genes in ocular melanoma cell lines. (9220316)
1997
26
Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector. (9375572)
1997
27
The ocular melanoma story. LIII Edward Jackson Memorial Lecture: Part II. (9535615)
1997
28
Immunoscintigraphy for ocular melanoma: a reliable diagnostic technique? (8720679)
1996
29
Effects of gamma radiation on the OM431 human ocular melanoma cell line. (7641843)
1995
30
Murine model of anterior and posterior ocular melanoma. (7648866)
1995
31
Estrogen and progesterone receptor analysis in ocular melanomas. (7891981)
1995
32
Intra-arterial hepatic carboplatin-based chemotherapy for ocular melanoma metastatic to the liver. Report of a phase II study. (8191596)
1994
33
Tamoxifen inhibition of ocular melanoma cell attachment to matrix proteins. (7855067)
1994
34
Investigation of the role of signal transduction in attachment of ocular melanoma cells to matrix proteins: inhibition of attachment by calmodulin antagonists including tamoxifen. (7923990)
1994
35
Gelatinolytic metalloproteinase secretion patterns in ocular melanoma. (1316333)
1992
36
The clinical status of immunoscintigraphy with monoclonal antibodies in ocular melanoma. (1856514)
1991
37
Ocular melanoma. (2337558)
1990
38
Regulation of the metastasis of murine ocular melanoma by natural killer cells. (2777511)
1989
39
Place of birth and incidence of ocular melanoma in the United States. (3196415)
1988
40
A treatment for metastasis of murine ocular melanoma. (3170123)
1988
41
Intracerebral metastases from ocular melanoma. (3378019)
1988
42
The use of video to monitor continuous gold laser photoradiation treatment of an ocular melanoma. (3340403)
1988
43
Trisomy 6p in an ocular melanoma. (3355994)
1988
44
Radio-iodine-labelled 5-iodo-2-thiouracil: a potential radiopharmaceutical for establishing the viability of ocular melanoma after radiation therapy. (3554049)
1986
45
Risk factors for ocular melanoma: Western Canada Melanoma Study. (3857374)
1985
46
Indirect ophthalmoscopy and ocular melanoma. (6425320)
1984
47
Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives. (6840126)
1983
48
Ocular melanoma: a challenge to visual science. Friedenwald lecture. (7129806)
1982
49
Tumor-associated antibodies in the serum of patients with ocular melanoma. IV. Correction for smooth muscle antibodies. (6997787)
1980
50
Metal isotopes used as radioactive indicators of ocular melanoma. (835671)
1977

Genetic Variations for Ocular Melanoma

Expression for genes affiliated with Ocular Melanoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ocular Melanoma

Search GEO for disease gene expression data for Ocular Melanoma.

Pathways for genes affiliated with Ocular Melanoma

Sources:
54Reactome
See all sources

Pathways related to Ocular Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PLG, CD63, GAS6

Compounds for genes affiliated with Ocular Melanoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Ocular Melanoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1phosphatidylserine45 29 1112.0S100A6, GAS6, ANXA6, AXL
2matrigel4510.0BRCA2, CYR61, PLG, SERPINF1
3glyceraldehyde 3-phosphate459.9HMBS, ANXA6, S100A11, S100A6
4paraffin459.8MAGEA1, MAGEA3, S100A6, BRCA2
5phosphatidylinositol459.8BRCA2, GAS6, CIITA, CD63, AXL, CYR61
6oligonucleotide459.8BRCA2, S100A6, CIITA, NRAS, MAGEA3, CYR61
7progesterone45 60 29 11 2413.5BRCA2, S100A6, ANXA6, CYR61, HMBS
8atp45 2910.5S100A6, S100A11, ANXA6, CD63, PLG, HMBS
9steroid459.4BRCA2, S100A6, CIITA, CYR61, PLG
10calcium45 50 11 2412.4SERPINF1, S100A11, PDCD6, GAS6, CIITA, ANXA6
11tyrosine459.4GAS6, CIITA, NRAS, ANXA6, CD63, AXL

GO Terms for genes affiliated with Ocular Melanoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Ocular Melanoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dendritic cell apoptotic processGO:200066910.5GAS6, AXL
2positive regulation of cytokine-mediated signaling pathwayGO:00196110.4AXL, GAS6
3cellular response to interferon-alphaGO:03545710.4AXL, GAS6
4negative regulation of tumor necrosis factor productionGO:03272010.4MC1R, AXL, GAS6
5enzyme linked receptor protein signaling pathwayGO:00716710.3GAS6, AXL
6positive regulation of protein kinase B signaling cascadeGO:05189710.3GAS6, AXL, MC1R
7dendritic cell differentiationGO:09702810.3GAS6, AXL
8positive regulation of natural killer cell differentiationGO:03282510.2AXL, GAS6
9platelet activationGO:03016810.1GAS6, PLG, AXL, CD63
10labyrinthine layer blood vessel developmentGO:06071610.1PLG, CYR61
11platelet degranulationGO:00257610.0PLG, CD63, GAS6
12apoptotic cell clearanceGO:0432779.9AXL, GAS6

Molecular functions related to Ocular Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1binding, bridgingGO:06009010.2GAS6, PDCD6
2S100 protein bindingGO:04454810.0S100A6, S100A11
3calcium-dependent protein bindingGO:0483069.9S100A6, S100A11, PDCD6
4phosphatidylserine bindingGO:0017869.9GAS6, AXL
5calcium ion bindingGO:0055099.6ANXA6, GAS6, PDCD6, S100A11, S100A6
6protein bindingGO:0055158.3BAP1, CIITA, MAGEA3, MAGEA1, CD63, AXL

Products for genes affiliated with Ocular Melanoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Melanoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet