MCID: OCL025
MIFTS: 27

Ocular Toxoplasmosis malady

Summaries for Ocular Toxoplasmosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Ocular toxoplasmosis is an infection in the eye caused by the parasite, toxoplasm a gondii.  toxoplasmosis is the most common cause of eye inflammation in the world.  toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. in humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  in individuals with compromised immune systems, toxoplasm a gondii can reactivate to cause disease.  reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.  a toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  however, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids. last updated: 8/2/2011

MalaCards: Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to tuberculosis and toxoplasmosis. An important gene associated with Ocular Toxoplasmosis is TLR1 (toll-like receptor 1), and among its related pathways are Immune response Bacterial infections in normal airways and NF-kappaB Signaling. The compounds loxoribine and resiquimod have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and placenta, and related mouse phenotype immune system.

Wikipedia:63 Toxoplasma chorioretinitis, more simply known as ocular toxoplasmosis, is probably the most common cause... more...

Aliases & Classifications for Ocular Toxoplasmosis

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42NIH Rare Diseases, 60UMLS, 44Novoseek
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Aliases & Descriptions:

ocular toxoplasmosis 42 60
toxoplasmosis ocular 44


Related Diseases for Ocular Toxoplasmosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to ocular toxoplasmosis

Clinical Features for Ocular Toxoplasmosis

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Drugs & Therapeutics for Ocular Toxoplasmosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ocular Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Ocular Toxoplasmosis

Search NIH Clinical Center for Ocular Toxoplasmosis

Search CenterWatch for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

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Anatomical Context for Ocular Toxoplasmosis

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32MalaCards
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MalaCards organs/tissues related to Ocular Toxoplasmosis:

32
Eye, Retina, Placenta, Testes

Animal Models for Ocular Toxoplasmosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1NOD2, TLR1, TLR9, TLR5

Publications for Ocular Toxoplasmosis

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Genetic Variations for Ocular Toxoplasmosis

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Expression for genes affiliated with Ocular Toxoplasmosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for genes affiliated with Ocular Toxoplasmosis

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Sources:
4Cell Signaling Technology, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 59Tocris Bioscience, 12EMD Millipore, 53Reactome
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Pathways related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
9.5TLR1, TLR5
29.4TLR1, TLR9
3
Hide members
8.9TLR5, TLR1, TLR9
48.9TLR5, TLR1, TLR9
58.9TLR5, TLR1, TLR9
6
Hide members
8.9TLR1, TLR5, TLR9
7
Hide members
8.9TLR1, TLR5, TLR9
8
Hide members
8.9TLR9, TLR5, TLR1
9
Hide members
8.9TLR9, TLR5, TLR1
10
Hide members
8.9TLR9, TLR1, TLR5
118.9TLR1, TLR9, TLR5
12
Hide members
8.9TLR1, TLR9, TLR5
13
Hide members
8.9TLR1, TLR9, TLR5
148.9TLR9, TLR5, TLR1
158.6NOD2, TLR9, TLR1
16
Hide members
8.1TLR1, TLR9, TLR5, NOD2
17
Hide members
8.1TLR5, TLR9, TLR1, NOD2

Compounds for genes affiliated with Ocular Toxoplasmosis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1loxoribine44 2810.3TLR9, TLR5
2resiquimod44 5910.3TLR1, TLR9
3poly(i-c)449.0TLR9, TLR5
4cytosine44 2410.0NOD2, TLR9
5flagellin44 2810.0TLR1, TLR9, TLR5
6lipoteichoic acid448.9TLR5, TLR9, TLR1
7peptidoglycan44 289.2NOD2, TLR1, TLR9, TLR5

GO Terms for genes affiliated with Ocular Toxoplasmosis

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16Gene Ontology
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Biological processes related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:0507079.7TLR1, TLR9
2positive regulation of toll-like receptor signaling pathwayGO:0341239.7TLR9, TLR5
3positive regulation of interleukin-8 productionGO:0327579.6TLR9, TLR5
4positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.3NOD2, TLR9
5positive regulation of interleukin-10 productionGO:0327339.3TLR9, NOD2
6positive regulation of interleukin-12 productionGO:0327359.3NOD2, TLR9
7positive regulation of tumor necrosis factor productionGO:0327609.3NOD2, TLR9
8toll-like receptor 10 signaling pathwayGO:0341669.2TLR5, NOD2
9positive regulation of interleukin-6 productionGO:0327559.2NOD2, TLR9
10positive regulation of JNK cascadeGO:0463309.2TLR9, NOD2
11toll-like receptor 5 signaling pathwayGO:0341469.2TLR5, NOD2
12negative regulation of NF-kappaB transcription factor activityGO:0320889.2NOD2, TLR9
13inflammatory responseGO:0069549.1TLR5, TLR9, TLR1
14toll-like receptor 9 signaling pathwayGO:0341629.0NOD2, TLR9
15positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0NOD2, TLR9
16defense response to bacteriumGO:0427428.9TLR9, NOD2
17toll-like receptor signaling pathwayGO:0022248.8TLR5, TLR9, NOD2
18positive regulation of NF-kappaB transcription factor activityGO:0510928.7NOD2, TLR9
19MyD88-dependent toll-like receptor signaling pathwayGO:0027558.4NOD2, TLR1, TLR9, TLR5
20innate immune responseGO:0450878.4TLR5, TLR9, TLR1, NOD2

Molecular functions related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR1, TLR9
2interleukin-1 receptor bindingGO:0051499.0TLR9, TLR5

Products for genes affiliated with Ocular Toxoplasmosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Toxoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet