MCID: OCL025
MIFTS: 40

Ocular Toxoplasmosis malady

Categories: Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

Aliases & Descriptions for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 50 69
Toxoplasmosis Ocular 52

Classifications:



Summaries for Ocular Toxoplasmosis

NIH Rare Diseases : 50 ocular toxoplasmosis is an infection in the eye caused by the parasite, toxoplasm a gondii. toxoplasmosis is the most common cause of eye inflammation in the world. toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus. most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. in humans, the infection usually causes no symptoms, and resolves without treatment in a few months. in individuals with compromised immune systems, toxoplasm a gondii can reactivate to cause disease.   reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. a toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. however, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids. last updated: 12/5/2016

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to uveitis and tuberculosis. An important gene associated with Ocular Toxoplasmosis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Pyrimethamine and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include eye, placenta and retina, and related phenotypes are hematopoietic system and immune system

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
id Related Disease Score Top Affiliating Genes
1 uveitis 30.0 CD40LG CD79A
2 tuberculosis 29.3 CD40LG IL17A TLR9
3 toxoplasmosis 10.9
4 ciliary discoordination, due to random ciliary orientation 10.3 CD79A MICA
5 amyotrophic lateral sclerosis type 10 10.3 CD79A NOD2
6 psoriatic arthritis 10.3 MICA NOD2
7 alcoholic neuropathy 10.2 CD40LG CD79A
8 camptodactyly vertebral fusion 10.2 CD40LG CD79A
9 spinal polio 10.2 CD40LG CD79A
10 rabies 10.2 CD40LG CD79A
11 unilateral retinoblastoma 10.2 CD40LG CD79A
12 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
13 delta chain disease 10.2 CD40LG CD79A
14 discitis 10.2 CD40LG CD79A
15 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
16 trichostrongyloidiasis 10.2 CD40LG CD79A
17 colloid adenoma 10.2 CD40LG CD79A
18 heart septal defect 10.2 CD40LG CD79A
19 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
20 mild pre-eclampsia 10.2 CD40LG CD79A
21 retinal microaneurysm 10.2 CD40LG CD79A
22 pediatric meningioma 10.2 CD40LG CD79A
23 tonsil cancer 10.2 CD40LG CD79A
24 postcricoid region cancer 10.2 CD40LG CD79A
25 beach ear 10.2 CD40LG CD79A
26 acute kidney tubular necrosis 10.2 CD40LG CD79A
27 atheroembolism of kidney 10.2 CD40LG CD79A
28 partial sensory epilepsy 10.2 CD40LG CD79A
29 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
30 diabetic angiopathy 10.2 CD40LG CD79A
31 endocarditis 10.2 CD40LG CD79A
32 muscular dystrophy 10.2 CD40LG CD79A
33 dumping syndrome 10.2 CD40LG CD79A
34 striatonigral degeneration 10.2 CD40LG CD79A
35 ciliary body spindle cell melanoma 10.2 CD40LG CD79A
36 purulent endophthalmitis 10.2 CD40LG CD79A
37 mu chain disease 10.2 CD40LG CD79A
38 generalized atherosclerosis 10.2 CD40LG CD79A
39 bursitis 10.2 CD40LG CD79A
40 syphilis 10.2 CD40LG CD79A
41 homocystinuria 10.2 CD40LG CD79A
42 mental retardation, autosomal dominant 19 10.2 CD40LG CD79A
43 hemangioma of orbit 10.2 CD40LG CD79A
44 leiomyosarcoma 10.2 CD40LG CD79A
45 immunoglobulin beta deficiency 10.2 CD40LG CD79A
46 gestational diabetes 10.2 CD40LG CD79A
47 chronic mucocutaneous candidiasis 10.2 CD40LG CD79A
48 primary thrombocytopenia 10.2 CD40LG CD79A
49 alkhurma hemorrhagic fever 10.2 CD40LG CD79A
50 polyneuropathy due to drug 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD40LG CD79A IL17A NOD2 TLR1 TLR5
2 immune system MP:0005387 9.17 CD40LG CD79A IL17A NOD2 TLR1 TLR5

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3,Phase 1 58-14-0 4993
2
Sulfadiazine Approved, Vet_approved Phase 4,Phase 3 68-35-9 5215
3
Bevacizumab Approved, Investigational Phase 4 216974-75-3
4
Levoleucovorin Approved Phase 4,Phase 3 68538-85-2
5
Spiramycin Approved Phase 4,Phase 3 24916-50-5
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1 58-05-9 54575, 6560146 143
8 Anti-Bacterial Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3,Phase 1
10 Antimalarials Phase 4,Phase 3,Phase 1
11 Antiparasitic Agents Phase 4,Phase 3,Phase 1
12 Antiprotozoal Agents Phase 4,Phase 3,Phase 1
13 Folic Acid Antagonists Phase 4,Phase 3,Phase 1
14 Protective Agents Phase 4,Phase 3
15 Vitamin B Complex Phase 4,Phase 3,Phase 1
16 Angiogenesis Inhibitors Phase 4
17 Angiogenesis Modulating Agents Phase 4
18 Antidotes Phase 4
19 Bone Density Conservation Agents Phase 4
20 Calcium, Dietary Phase 4
21 Micronutrients Phase 4
22 Trace Elements Phase 4
23 Vitamins Phase 4
24 Folate Nutraceutical Phase 4,Phase 3,Phase 1
25 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 1
26
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
27
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
28
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
29
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
30
Sulfamethoxazole Approved Phase 3 723-46-6 5329
31
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
32 Antiemetics Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Antineoplastic Agents, Hormonal Phase 3
35 Autonomic Agents Phase 3
36 BB 1101 Phase 3
37 Clindamycin palmitate Phase 3
38 Clindamycin phosphate Phase 3
39 Dexamethasone 21-phosphate Phase 3
40 Dexamethasone acetate Phase 3 1177-87-3
41 Gastrointestinal Agents Phase 3
42 glucocorticoids Phase 3
43 HIV Protease Inhibitors Phase 3,Phase 1
44 Hormone Antagonists Phase 3
45 Hormones Phase 3
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
47 Methylprednisolone acetate Phase 3
48 Methylprednisolone Hemisuccinate Phase 3
49 Neuroprotective Agents Phase 3
50 Peripheral Nervous System Agents Phase 3

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4
3 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
4 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3
5 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3
6 Antiretroviral Drug Interaction Study in Volunteers With HIV Completed NCT01479361 Phase 1
7 A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis Withdrawn NCT00679744 Phase 1
8 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
9 Uveitis Gene-Expression Profiling Completed NCT00874471
10 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
11 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Not yet recruiting NCT02863588
12 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

39
Eye, Placenta, Retina, T Cells, Testes, B Cells, Kidney

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 404)
id Title Authors Year
1
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
2
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
3
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
4
Late isolated ocular toxoplasmosis in a belatacept-treated kidney-transplant patient. ( 27614031 )
2016
5
Ocular Toxoplasmosis: an Update. ( 27116531 )
2016
6
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands. ( 27827450 )
2016
7
Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa. ( 26786055 )
2016
8
Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia. ( 26957857 )
2016
9
Clinical Features and Risk Factors of Patients with Presumed Ocular Toxoplasmosis. ( 27195085 )
2016
10
Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists. ( 27598330 )
2016
11
Reactivation of Ocular Toxoplasmosis in Non-Hispanic Persons, Misiones Province, Argentina. ( 27089308 )
2016
12
Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review. ( 27389360 )
2016
13
Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States. ( 27892751 )
2016
14
Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. ( 26010656 )
2015
15
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis. ( 26643197 )
2015
16
Toxoplasma Gondii Infection of Chicken Embryos Causes Retinal Changes and Modulates HSP90B1 Gene Expression: A Promising Ocular Toxoplasmosis Model. ( 26716020 )
2015
17
Influence of drug therapy on the risk of recurrence of ocular toxoplasmosis. ( 26163541 )
2015
18
Volume Rendering of Optical Coherence Tomography Angiography Reveals Extensive Retinal Vascular Contributions to Neovascularization in Ocular Toxoplasmosis. ( 26405767 )
2015
19
Ocular toxoplasmosis: lessons from Brazil. ( 25956461 )
2015
20
IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model. ( 25693767 )
2015
21
Correction: Subretinal Fluid in Eyes with Active Ocular Toxoplasmosis Observed Using Spectral Domain Optical Coherence Tomography. ( 26196292 )
2015
22
Interleukin-6-driven inflammatory response induces retinal pathology in a model of ocular toxoplasmosis reactivation. ( 25754200 )
2015
23
Acquired ocular toxoplasmosis in a patient with thymoma. ( 25682923 )
2015
24
Coexisting choroidal neovascularization and active retinochoroiditis-an uncommon presentation of ocular toxoplasmosis. ( 26185543 )
2015
25
MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis. ( 26672749 )
2015
26
Ocular Toxoplasmosis. ( 26066570 )
2015
27
Roth Spots in Ocular Toxoplasmosis. ( 26472315 )
2015
28
Fulminant Ocular Toxoplasmosis: The Hazards of Corticosteroid Monotherapy. ( 26647176 )
2015
29
Real-time PCR using the 529a88bp repeat element for the diagnosis of atypical ocular toxoplasmosis. ( 26174811 )
2015
30
Ocular toxoplasmosis: background and evidence for an antibiotic prophylaxis. ( 26367087 )
2015
31
The role of serological titres in the diagnosis of ocular toxoplasmosis. ( 26426456 )
2015
32
Current Therapy of Acquired Ocular Toxoplasmosis: A Review. ( 26226199 )
2015
33
Ocular toxoplasmosis: a very rare presentation in an immunocompetent patient. ( 25270156 )
2014
34
PCR-Based Detection of Toxoplasma gondii DNA in Blood and Ocular Samples for Diagnosis of Ocular Toxoplasmosis. ( 25210066 )
2014
35
Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report. ( 24694257 )
2014
36
RETINAL DETACHMENT ASSOCIATED WITH OCULAR TOXOPLASMOSIS. ( 25127047 )
2014
37
Risk of Recurrence of Preexisting Ocular Toxoplasmosis during Pregnancy. ( 24841072 )
2014
38
Ocular toxoplasmosis past, present and new aspects of an old disease. ( 24412517 )
2014
39
New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. ( 24200675 )
2014
40
Successful treatment of ocular toxoplasmosis that developed four years after kidney transplantation. ( 25160074 )
2014
41
Cuban Ocular Toxoplasmosis Epidemiology Study (COTES): incidence and prevalence of ocular toxoplasmosis in Central Cuba. ( 25253767 )
2014
42
Cerebral and ocular toxoplasmosis related with IFN-I^, TNF-I+, and IL-10 levels. ( 25352834 )
2014
43
MA1ller cell activation and photoreceptor depletion in a mice model of congenital ocular toxoplasmosis. ( 24929147 )
2014
44
Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications. ( 25248050 )
2014
45
Recurrence Rates of Ocular Toxoplasmosis During Pregnancy. ( 24412127 )
2014
46
Risk factors for ocular toxoplasmosis in Brazil. ( 23507508 )
2014
47
Excretory-secretory antigens: a suitable candidate for immunization against ocular toxoplasmosis in a murine model. ( 25467037 )
2014
48
Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography. ( 24505261 )
2014
49
TIME PATTERNS OF RECURRENCES AND FACTORS PREDISPOSING FOR A HIGHER RISK OF RECURRENCE OF OCULAR TOXOPLASMOSIS. ( 25299969 )
2014
50
Ocular Toxoplasmosis in the United States: Recent and Remote Infections. ( 25301214 )
2014

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CD40LG CD79A IGHE IL17A MICA NOD2
2
Show member pathways
13.09 CD40LG IL17A TLR1 TLR5 TLR9
3
Show member pathways
12.7 NOD2 TLR1 TLR5 TLR9
4
Show member pathways
12.32 CD40LG TLR1 TLR5 TLR9
5
Show member pathways
12.31 CD40LG TLR1 TLR5 TLR9
6
Show member pathways
11.99 TLR1 TLR5 TLR9
7 11.95 NOD2 TLR1 TLR9
8
Show member pathways
11.9 TLR1 TLR5 TLR9
9 11.89 TLR1 TLR5 TLR9
10 11.85 CD40LG CD79A IL17A TLR1 TLR9
11 11.76 TLR1 TLR5 TLR9
12
Show member pathways
11.7 TLR1 TLR5 TLR9
13
Show member pathways
11.49 IL17A TLR1 TLR5 TLR9
14 11.47 TLR1 TLR5 TLR9
15 11.34 CD40LG TLR5 TLR9
16 11.14 CD40LG CD79A
17
Show member pathways
10.93 IL17A TLR1 TLR5 TLR9

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A IGHE IL17A

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.84 CD40LG IGHE IL17A TLR1
2 innate immune response GO:0045087 9.83 IGHE NOD2 TLR1 TLR5 TLR9
3 immune system process GO:0002376 9.8 CD79A NOD2 TLR1 TLR5 TLR9
4 inflammatory response GO:0006954 9.72 CD40LG IL17A TLR1 TLR5 TLR9
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 CD40LG NOD2 TLR9
6 toll-like receptor signaling pathway GO:0002224 9.58 TLR1 TLR9
7 positive regulation of interleukin-6 production GO:0032755 9.57 NOD2 TLR9
8 B cell proliferation GO:0042100 9.56 CD40LG CD79A
9 positive regulation of interleukin-12 production GO:0032735 9.55 CD40LG TLR9
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.54 TLR1 TLR5 TLR9
11 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 NOD2 TLR9
12 maintenance of gastrointestinal epithelium GO:0030277 9.49 NOD2 TLR9
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.48 IL17A NOD2
14 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR5 TLR9
15 positive regulation of interleukin-8 production GO:0032757 9.43 NOD2 TLR5 TLR9
16 positive regulation of interleukin-10 production GO:0032733 9.33 CD40LG NOD2 TLR9
17 regulation of cytokine secretion GO:0050707 9.13 TLR1 TLR5 TLR9
18 defense response to bacterium GO:0042742 9.1 IGHE MICA NOD2 TLR1 TLR5 TLR9

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 CD79A TLR1 TLR5 TLR9

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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