MCID: OCL025
MIFTS: 39

Ocular Toxoplasmosis

Categories: Rare diseases

Aliases & Classifications for Ocular Toxoplasmosis

MalaCards integrated aliases for Ocular Toxoplasmosis:

Name: Ocular Toxoplasmosis 50 69
Toxoplasmosis Ocular 52

Classifications:



Summaries for Ocular Toxoplasmosis

NIH Rare Diseases : 50 ocular toxoplasmosis is an infection in the eye caused by the parasite, toxoplasm a gondii. toxoplasmosis is the most common cause of eye inflammation in the world. toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus. most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. in humans, the infection usually causes no symptoms, and resolves without treatment in a few months. in individuals with compromised immune systems, toxoplasm a gondii can reactivate to cause disease.   reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common. a toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms. however, the inactive parasite may later reactivate causing eye pain, blurred vision, and possibly permanent damage, including blindness. although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids. last updated: 12/5/2016

MalaCards based summary : Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to uveitis and lymphoma. An important gene associated with Ocular Toxoplasmosis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Bevacizumab and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and placenta, and related phenotypes are hematopoietic system and immune system

Related Diseases for Ocular Toxoplasmosis

Diseases related to Ocular Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
id Related Disease Score Top Affiliating Genes
1 uveitis 30.5 CD40LG CD79A
2 lymphoma 28.5 CD40LG CD79A IL17A TLR9
3 toxoplasmosis 10.9
4 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.7 CD79A MICA
5 alcoholic neuropathy 10.6 CD40LG CD79A
6 calloso-genital dysplasia 10.6 CD40LG CD79A
7 variola major 10.6 CD40LG CD79A
8 mu chain disease 10.6 CD40LG CD79A
9 rabies 10.6 CD40LG CD79A
10 familial retinoblastoma 10.6 CD40LG CD79A
11 anti-basement membrane glomerulonephritis 10.6 CD40LG CD79A
12 microinvasive cervical squamous cell carcinoma 10.6 CD40LG CD79A
13 deafness, autosomal recessive 67 10.6 MICA NOD2
14 fetal erythroblastosis 10.6 CD40LG CD79A
15 spinal canal and spinal cord meningioma 10.6 CD40LG CD79A
16 trichostrongyloidiasis 10.6 CD40LG CD79A
17 leukodystrophy 10.6 CD40LG CD79A
18 retinal microaneurysm 10.6 CD40LG CD79A
19 heart septal defect 10.6 CD40LG CD79A
20 cryptorchidism arachnodactyly mental retardation 10.6 CD40LG CD79A
21 acute kidney tubular necrosis 10.6 CD40LG CD79A
22 secretory meningioma 10.6 CD40LG CD79A
23 hodgkin's lymphoma, nodular sclerosis 10.6 CD40LG CD79A
24 malignant otitis externa 10.6 CD40LG CD79A
25 transient hypogammaglobulinemia 10.6 CD40LG CD79A
26 benign epilepsy with centrotemporal spikes 10.6 CD40LG CD79A
27 tongue cancer 10.6 CD40LG CD79A
28 hydrops of gallbladder 10.6 CD40LG CD79A
29 gamma heavy chain disease 10.6 CD40LG CD79A
30 diabetic angiopathy 10.6 CD40LG CD79A
31 rosacea conjunctivitis 10.6 CD40LG CD79A
32 viral meningitis 10.6 CD40LG CD79A
33 heart fibrosarcoma 10.6 CD40LG CD79A
34 alopecia areata 10.6 CD40LG CD79A
35 kidney carcinoma in situ 10.6 CD40LG CD79A
36 cardiac tuberculosis 10.6 CD40LG CD79A
37 dumping syndrome 10.6 CD40LG CD79A
38 leiomyosarcoma 10.5 CD40LG CD79A
39 periarthritis 10.5 CD40LG CD79A
40 generalized atherosclerosis 10.5 CD40LG CD79A
41 colonic benign neoplasm 10.5 CD40LG CD79A
42 cerebral neuroblastoma 10.5 CD40LG CD79A
43 pancreatic vasoactive intestinal peptide producing tumor 10.5 CD40LG CD79A
44 aniseikonia 10.5 CD40LG CD79A
45 gestational diabetes 10.5 CD40LG CD79A
46 polyneuropathy due to drug 10.5 CD40LG CD79A
47 chronic mucocutaneous candidiasis 10.5 CD40LG CD79A
48 cutaneous ganglioneuroma 10.5 CD40LG CD79A
49 acute hemorrhagic encephalitis 10.5 CD40LG CD79A
50 mental retardation, autosomal dominant 19 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to Ocular Toxoplasmosis

Symptoms & Phenotypes for Ocular Toxoplasmosis

MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 IL17A NOD2 TLR1 TLR5 TLR9 CD40LG
2 immune system MP:0005387 9.17 IL17A NOD2 TLR1 TLR5 TLR9 CD40LG

Drugs & Therapeutics for Ocular Toxoplasmosis

Drugs for Ocular Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Levoleucovorin Approved Phase 4,Phase 3 68538-85-2
3
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3 58-14-0 4993
4
Spiramycin Approved Phase 4,Phase 3 24916-50-5
5
Sulfadiazine Approved, Vet_approved Phase 4,Phase 3 68-35-9 5215
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
8 Angiogenesis Inhibitors Phase 4
9 Angiogenesis Modulating Agents Phase 4
10 Anti-Bacterial Agents Phase 4,Phase 3
11 Anti-Infective Agents Phase 4,Phase 3
12 Antimalarials Phase 4,Phase 3
13 Antiparasitic Agents Phase 4,Phase 3
14 Antiprotozoal Agents Phase 4,Phase 3
15 Folic Acid Antagonists Phase 4,Phase 3
16 Vitamin B Complex Phase 4,Phase 3
17 Antidotes Phase 4
18 Bone Density Conservation Agents Phase 4
19 Calcium, Dietary Phase 4
20 Micronutrients Phase 4
21 Protective Agents Phase 4
22 Trace Elements Phase 4
23 Vitamins Phase 4
24 Folate Nutraceutical Phase 4,Phase 3
25 Vitamin B9 Nutraceutical Phase 4,Phase 3
26
Sulfamethoxazole Approved Phase 3 723-46-6 5329
27
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
28 Cytochrome P-450 Enzyme Inhibitors Phase 3
29 Renal Agents Phase 3
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
31 Anti-Inflammatory Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
3 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
4 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3 Pyrimethamine/Sulfadiazine;Spiramycine
5 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
6 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588
7 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

MalaCards organs/tissues related to Ocular Toxoplasmosis:

39
Eye, Retina, Placenta, Bone, T Cells, Testes, Kidney

Publications for Ocular Toxoplasmosis

Articles related to Ocular Toxoplasmosis:

(show top 50) (show all 413)
id Title Authors Year
1
Corticosteroids as adjuvant therapy for ocular toxoplasmosis. ( 28125765 )
2017
2
False Negative Toxoplasma Serology in an Immunocompromised Patient with PCR Positive Ocular Toxoplasmosis. ( 28700250 )
2017
3
Causes of visual impairment in patients with ocular toxoplasmosis. ( 28248682 )
2017
4
Ocular Toxoplasmosis: Therapy-Related Adverse Drug Reactions and Their Management. ( 28329892 )
2017
5
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis. ( 28836673 )
2017
6
T cell immunoregulation in active ocular toxoplasmosis. ( 28214536 )
2017
7
Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis. ( 28448726 )
2017
8
The use of ELISA, nPCR and qPCR for diagnosis of ocular toxoplasmosis in experimentally infected pigs. ( 28787692 )
2017
9
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
10
Ocular Toxoplasmosis: an Update. ( 27116531 )
2016
11
Current Practices in Ocular Toxoplasmosis: A Survey of Brazilian Uveitis Specialists. ( 27598330 )
2016
12
Genotyping of Toxoplasma gondii Strains Isolated from Patients with Ocular Toxoplasmosis in Iran. ( 28127336 )
2016
13
Late isolated ocular toxoplasmosis in a belatacept-treated kidney-transplant patient. ( 27614031 )
2016
14
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands. ( 27827450 )
2016
15
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
16
Clinical Features and Risk Factors of Patients with Presumed Ocular Toxoplasmosis. ( 27195085 )
2016
17
Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia. ( 26957857 )
2016
18
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
19
Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa. ( 26786055 )
2016
20
Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review. ( 27389360 )
2016
21
Reactivation of Ocular Toxoplasmosis in Non-Hispanic Persons, Misiones Province, Argentina. ( 27089308 )
2016
22
Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States. ( 27892751 )
2016
23
Toxoplasma Gondii Infection of Chicken Embryos Causes Retinal Changes and Modulates HSP90B1 Gene Expression: A Promising Ocular Toxoplasmosis Model. ( 26716020 )
2015
24
Ocular toxoplasmosis: background and evidence for an antibiotic prophylaxis. ( 26367087 )
2015
25
Influence of drug therapy on the risk of recurrence of ocular toxoplasmosis. ( 26163541 )
2015
26
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis. ( 26643197 )
2015
27
Correction: Subretinal Fluid in Eyes with Active Ocular Toxoplasmosis Observed Using Spectral Domain Optical Coherence Tomography. ( 26196292 )
2015
28
Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. ( 26010656 )
2015
29
Coexisting choroidal neovascularization and active retinochoroiditis-an uncommon presentation of ocular toxoplasmosis. ( 26185543 )
2015
30
Current Therapy of Acquired Ocular Toxoplasmosis: A Review. ( 26226199 )
2015
31
Roth Spots in Ocular Toxoplasmosis. ( 26472315 )
2015
32
Ocular toxoplasmosis: lessons from Brazil. ( 25956461 )
2015
33
The role of serological titres in the diagnosis of ocular toxoplasmosis. ( 26426456 )
2015
34
Volume Rendering of Optical Coherence Tomography Angiography Reveals Extensive Retinal Vascular Contributions to Neovascularization in Ocular Toxoplasmosis. ( 26405767 )
2015
35
MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis. ( 26672749 )
2015
36
Ocular Toxoplasmosis. ( 26066570 )
2015
37
Fulminant Ocular Toxoplasmosis: The Hazards of Corticosteroid Monotherapy. ( 26647176 )
2015
38
Interleukin-6-driven inflammatory response induces retinal pathology in a model of ocular toxoplasmosis reactivation. ( 25754200 )
2015
39
IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model. ( 25693767 )
2015
40
Acquired ocular toxoplasmosis in a patient with thymoma. ( 25682923 )
2015
41
Real-time PCR using the 529a88bp repeat element for the diagnosis of atypical ocular toxoplasmosis. ( 26174811 )
2015
42
Ocular toxoplasmosis: a very rare presentation in an immunocompetent patient. ( 25270156 )
2014
43
Cuban Ocular Toxoplasmosis Epidemiology Study (COTES): incidence and prevalence of ocular toxoplasmosis in Central Cuba. ( 25253767 )
2014
44
Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography. ( 24505261 )
2014
45
New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. ( 24200675 )
2014
46
Excretory-secretory antigens: a suitable candidate for immunization against ocular toxoplasmosis in a murine model. ( 25467037 )
2014
47
Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report. ( 24694257 )
2014
48
TIME PATTERNS OF RECURRENCES AND FACTORS PREDISPOSING FOR A HIGHER RISK OF RECURRENCE OF OCULAR TOXOPLASMOSIS. ( 25299969 )
2014
49
Epidemiological and serological profiles of ocular toxoplasmosis in the municipality of Natal, northeastern Brazil. ( 25096294 )
2014
50
PCR-Based Detection of Toxoplasma gondii DNA in Blood and Ocular Samples for Diagnosis of Ocular Toxoplasmosis. ( 25210066 )
2014

Variations for Ocular Toxoplasmosis

Expression for Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for Ocular Toxoplasmosis

Pathways related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CD40LG CD79A IGHE IL17A MICA NOD2
2
Show member pathways
13.09 CD40LG IL17A TLR1 TLR5 TLR9
3
Show member pathways
12.67 NOD2 TLR1 TLR5 TLR9
4
Show member pathways
12.32 CD40LG TLR1 TLR5 TLR9
5
Show member pathways
12.31 CD40LG TLR1 TLR5 TLR9
6 12.05 CD40LG CD79A IL17A TLR1 TLR9
7 11.95 NOD2 TLR1 TLR9
8
Show member pathways
11.9 TLR1 TLR5 TLR9
9 11.89 TLR1 TLR5 TLR9
10 11.76 TLR1 TLR5 TLR9
11
Show member pathways
11.7 TLR1 TLR5 TLR9
12 11.47 TLR1 TLR5 TLR9
13 11.34 CD40LG TLR5 TLR9
14
Show member pathways
11.29 IL17A TLR1 TLR5 TLR9
15 11.13 CD40LG CD79A
16
Show member pathways
10.93 IL17A TLR1 TLR5 TLR9

GO Terms for Ocular Toxoplasmosis

Cellular components related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.5 CD40LG CD79A MICA NOD2 TLR1 TLR5
2 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A IGHE IL17A

Biological processes related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CD40LG IGHE IL17A TLR1
2 innate immune response GO:0045087 9.83 IGHE NOD2 TLR1 TLR5 TLR9
3 inflammatory response GO:0006954 9.77 CD40LG IL17A TLR1 TLR5 TLR9
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CD40LG NOD2 TLR9
5 toll-like receptor signaling pathway GO:0002224 9.58 TLR1 TLR9
6 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.58 TLR1 TLR5 TLR9
7 B cell proliferation GO:0042100 9.57 CD40LG CD79A
8 positive regulation of interleukin-12 production GO:0032735 9.56 CD40LG TLR9
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.52 IL17A NOD2
10 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 NOD2 TLR9
11 positive regulation of interleukin-8 production GO:0032757 9.5 NOD2 TLR5 TLR9
12 maintenance of gastrointestinal epithelium GO:0030277 9.49 NOD2 TLR9
13 positive regulation of B cell activation GO:0050871 9.48 IGHE NOD2
14 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR5 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.43 CD40LG NOD2 TLR9
16 immune system process GO:0002376 9.35 CD79A NOD2 TLR1 TLR5 TLR9
17 regulation of cytokine secretion GO:0050707 9.33 TLR1 TLR5 TLR9
18 defense response to bacterium GO:0042742 9.1 IGHE MICA NOD2 TLR1 TLR5 TLR9

Molecular functions related to Ocular Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 CD79A TLR1 TLR5 TLR9

Sources for Ocular Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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