MCID: OCL025
MIFTS: 36

Ocular Toxoplasmosis malady

Summaries for Ocular Toxoplasmosis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Ocular toxoplasmosis is an infection in the eye caused by the parasite, toxoplasm a gondii.  toxoplasmosis is the most common cause of eye inflammation in the world.  toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. in humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  in individuals with compromised immune systems, toxoplasm a gondii can reactivate to cause disease.  reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.  a toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  however, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids. last updated: 8/2/2011

MalaCards: Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to tuberculosis and toxoplasmosis. An important gene associated with Ocular Toxoplasmosis is TLR1 (toll-like receptor 1), and among its related pathways are Immune response Bacterial infections in normal airways and NF-kappaB Signaling. The compounds loxoribine and resiquimod have been mentioned in the context of this disorder. Affiliated tissues include retina, placenta and t cells, and related mouse phenotype immune system.

Wikipedia:64 Toxoplasma chorioretinitis is probably the most common cause of infections in the back of the eye... more...

Aliases & Classifications for Ocular Toxoplasmosis

Sources:
43NIH Rare Diseases, 61UMLS, 45Novoseek
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Aliases & Descriptions:

ocular toxoplasmosis 43 61
toxoplasmosis ocular 45


Related Diseases for Ocular Toxoplasmosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to ocular toxoplasmosis

Clinical Features for Ocular Toxoplasmosis

Drugs & Therapeutics for Ocular Toxoplasmosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Ocular Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Ocular Toxoplasmosis

Search NIH Clinical Center for Ocular Toxoplasmosis

Search CenterWatch for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

Anatomical Context for Ocular Toxoplasmosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Ocular Toxoplasmosis:

33
Retina, Placenta, T cells, B cells, Endothelial

Animal Models for Ocular Toxoplasmosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1NOD2, TLR1, TLR9, TLR5

Publications for Ocular Toxoplasmosis

Sources:
51PubMed
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Articles related to Ocular Toxoplasmosis:

(show top 50)    (show all 368)
idTitleAuthorsYear
1
Ocular toxoplasmosis past, present and new aspects of an old disease. (24412517)
2014
2
Case report of a neonate with ocular toxoplasmosis due to congenital infection: estimation of the percentage of ocular toxoplasmosis in Greece caused by congenital or acquired infection. (24293989)
2013
3
Ocular toxoplasmosis. (23474940)
2013
4
Imaging in ocular toxoplasmosis. (22954935)
2012
5
Ocular toxoplasmosis in Iran: 40 cases analysis. (22553642)
2011
6
Contribution of laboratory methods in diagnosing clinically suspected ocular toxoplasmosis in Brazilian patients. (21683267)
2011
7
Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. (20708269)
2011
8
Clinical features of ocular toxoplasmosis in Korean patients. (21738273)
2011
9
Contribution of anti-Hsp70.1 IgG antibody levels to the diagnostic certainty of clinically suspected ocular toxoplasmosis. (20554617)
2010
10
The role of DNA microarrays in Toxoplasma gondii research, the causative agent of ocular toxoplasmosis. (20157353)
2009
11
Trimethoprim/Sulfamethoxazole and azithromycin combination therapy for ocular toxoplasmosis. (19657985)
2009
12
Optical coherence tomography in ocular toxoplasmosis. (19319235)
2009
13
Immunopathology in ocular toxoplasmosis: facts and clues. (19430646)
2009
14
The temperature-sensitive mutants of Toxoplasma gondii and ocular toxoplasmosis. (19026704)
2009
15
Azithromycin reduces ocular infection during congenital transmission of toxoplasmosis in the Calomys callosus model. (20050006)
2009
16
Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. (18698419)
2008
17
Association of ocular toxoplasmosis with type I Toxoplasma gondii strains: direct genotyping from peripheral blood samples. (17005742)
2006
18
Ocular toxoplasmosis in pregnancy. (16181268)
2005
19
Fuchs' heterochromic iridocyclitis following bilateral ocular toxoplasmosis. (15209468)
2004
20
Ocular toxoplasmosis: clinical features and prognosis of 154 patients. (11986090)
2002
21
Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6. (11254623)
2001
22
Clinical ocular toxoplasmosis in neonatal kittens. (11422988)
2001
23
Histopathological features of ocular toxoplasmosis in the fetus and infant. (11146726)
2001
24
Is ocular toxoplasmosis caused by prenatal or postnatal infection? (10655202)
2000
25
Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in colombian patients with acute and chronic ocular toxoplasmosis. (10656711)
2000
26
Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice. (9916110)
1999
27
Acquired and congenital ocular toxoplasmosis experimentally induced in Calomys callosus (Rodentia, Cricetidae). (10029920)
1999
28
Experimental ocular toxoplasmosis in naive and primed rabbits. (9486555)
1998
29
Association of ocular toxoplasmosis and thymoma. (9279956)
1997
30
Presumed acquired ocular toxoplasmosis. (7487620)
1995
31
Contralateral active ocular toxoplasmosis in Fuchs' heterochromic cyclitis. (8343479)
1993
32
Other infections of the choroid and retina. Toxoplasmosis, histoplasmosis, Lyme disease, syphilis, tuberculosis, and ocular toxocariasis. (1460269)
1992
33
Serological investigation of ocular toxoplasmosis. (2043579)
1991
34
Visual impairment and blindness in ocular toxoplasmosis cases. (1822947)
1991
35
The epidemiologic association of Fuchs' heterochromic iridocyclitis and ocular toxoplasmosis. (2000906)
1991
36
Ocular toxoplasmosis in AIDS patients. (2095034)
1990
37
Experimental ocular toxoplasmosis with RH strain of Toxoplasma gondii. (3254427)
1988
38
Ocular toxoplasmosis in an elderly woman. (7147202)
1982
39
The role of hypersensitivity reactions to toxoplasma antigens in experimental ocular toxoplasmosis in nonhuman primates. (6810699)
1982
40
Longitudinal study of serum antibody responses to retinal antigens in acute ocular toxoplasmosis. (7039327)
1982
41
Ocular toxoplasmosis and visual field defects. (7395956)
1980
42
Presumed ocular toxoplasmosis: some clinical observations. (525667)
1979
43
Ocular toxoplasmosis in wallabies (Macropus rufogriseus). (384800)
1979
44
Diagnosis of ocular toxoplasmosis. (4448538)
1974
45
Studies on experimental ocular toxoplasmosis in the rabbit. II. Attempts to stimulate recurrences by local trauma, epinephrine, and corticosteroids. (5487445)
1970
46
The infleunce of hypersensitivity on the pathogenesis of ocular toxoplasmosis. (5524216)
1970
47
Antibody tests for ocular toxoplasmosis. (14469030)
1962
48
Ocular toxoplasmosis in adult patients. (13908215)
1961
49
Ocular toxoplasmosis; pathogenesis, diagnosis and treatment. (13497381)
1958
50
Adult ocular toxoplasmosis; report of a parasitologically proved case. (13170866)
1954

Genetic Variations for Ocular Toxoplasmosis

Expression for genes affiliated with Ocular Toxoplasmosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for genes affiliated with Ocular Toxoplasmosis

Sources:
4Cell Signaling Technology, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 56SinoBiological, 53R&D Systems, 12EMD Millipore, 60Tocris Bioscience, 54Reactome
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Pathways related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
9.5TLR5, TLR1
29.4TLR1, TLR9
3
Hide members
8.9TLR1, TLR9, TLR5
4
Hide members
8.9TLR5, TLR9, TLR1
5
Hide members
8.9TLR1, TLR9, TLR5
6
Hide members
8.9TLR1, TLR9, TLR5
7
Hide members
8.9TLR1, TLR9, TLR5
88.9TLR1, TLR9, TLR5
9
Hide members
8.9TLR5, TLR9, TLR1
108.9TLR1, TLR9, TLR5
11
Hide members
8.9TLR1, TLR9, TLR5
128.9TLR5, TLR9, TLR1
138.9TLR1, TLR9, TLR5
14
Hide members
8.9TLR5, TLR9, TLR1
158.6TLR9, TLR1, NOD2
16
Hide members
8.1TLR5, TLR9, TLR1, NOD2
17
Hide members
8.1NOD2, TLR1, TLR9, TLR5

Compounds for genes affiliated with Ocular Toxoplasmosis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1loxoribine45 2910.3TLR9, TLR5
2resiquimod45 6010.3TLR1, TLR9
3poly(i-c)459.0TLR9, TLR5
4cytosine45 2410.0NOD2, TLR9
5flagellin45 2910.0TLR1, TLR9, TLR5
6lipoteichoic acid458.9TLR5, TLR9, TLR1
7peptidoglycan45 299.2NOD2, TLR1, TLR9, TLR5

GO Terms for genes affiliated with Ocular Toxoplasmosis

Sources:
16Gene Ontology
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Biological processes related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:0507079.7TLR1, TLR9
2positive regulation of toll-like receptor signaling pathwayGO:0341239.7TLR9, TLR5
3positive regulation of interleukin-8 productionGO:0327579.6TLR9, TLR5
4positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.3TLR9, NOD2
5positive regulation of interleukin-10 productionGO:0327339.3NOD2, TLR9
6positive regulation of interleukin-12 productionGO:0327359.3TLR9, NOD2
7positive regulation of tumor necrosis factor productionGO:0327609.3TLR9, NOD2
8toll-like receptor 5 signaling pathwayGO:0341469.2NOD2, TLR5
9positive regulation of interleukin-6 productionGO:0327559.2NOD2, TLR9
10positive regulation of JNK cascadeGO:0463309.2NOD2, TLR9
11toll-like receptor 10 signaling pathwayGO:0341669.2TLR5, NOD2
12negative regulation of NF-kappaB transcription factor activityGO:0320889.2NOD2, TLR9
13inflammatory responseGO:0069549.1TLR1, TLR5, TLR9
14toll-like receptor 9 signaling pathwayGO:0341629.0NOD2, TLR9
15positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0NOD2, TLR9
16defense response to bacteriumGO:0427428.9NOD2, TLR9
17toll-like receptor signaling pathwayGO:0022248.8NOD2, TLR5, TLR9
18positive regulation of NF-kappaB transcription factor activityGO:0510928.7NOD2, TLR9
19MyD88-dependent toll-like receptor signaling pathwayGO:0027558.4TLR9, NOD2, TLR1, TLR5
20innate immune responseGO:0450878.4TLR5, TLR9, NOD2, TLR1

Molecular functions related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR1, TLR9
2interleukin-1 receptor bindingGO:0051499.0TLR9, TLR5

Products for genes affiliated with Ocular Toxoplasmosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ocular Toxoplasmosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet