MCID: OCL025
MIFTS: 41

Ocular Toxoplasmosis malady

Rare diseases category
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Summaries for Ocular Toxoplasmosis

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Ocular toxoplasmosis is an infection in the eye caused by the parasite, toxoplasm a gondii.  toxoplasmosis is the most common cause of eye inflammation in the world.  toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. in humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  in individuals with compromised immune systems, toxoplasm a gondii can reactivate to cause disease.  reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.  a toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  however, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids. last updated: 8/2/2011

MalaCards: Ocular Toxoplasmosis, also known as toxoplasmosis ocular, is related to tuberculosis and toxoplasmosis. An important gene associated with Ocular Toxoplasmosis is TLR1 (toll-like receptor 1), and among its related pathways are NF-kappaB Signaling and Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds resiquimod and cytosine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are digestive/alimentary and hematopoietic system.

Wikipedia:65 Toxoplasma chorioretinitis, more simply known as ocular toxoplasmosis, is probably the most common cause... more...

Aliases & Classifications for Ocular Toxoplasmosis

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43NIH Rare Diseases, 62UMLS, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

ocular toxoplasmosis 43 62
toxoplasmosis ocular 45


Related Diseases for Ocular Toxoplasmosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ocular Toxoplasmosis:



Diseases related to ocular toxoplasmosis

Symptoms for Ocular Toxoplasmosis

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Drugs & Therapeutics for Ocular Toxoplasmosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Ocular Toxoplasmosis

Search NIH Clinical Center for Ocular Toxoplasmosis

Genetic Tests for Ocular Toxoplasmosis

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Anatomical Context for Ocular Toxoplasmosis

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33MalaCards
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MalaCards organs/tissues related to Ocular Toxoplasmosis:

33
Eye, Testes, Retina, Placenta, T cells, B cells, Endothelial

Animal Models for Ocular Toxoplasmosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ocular Toxoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5TLR9, TLR5, NOD2
2MP:00053977.9TLR9, TLR1, TLR5, NOD2
3MP:00053877.7TLR9, TLR1, TLR5, NOD2

Publications for Ocular Toxoplasmosis

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52PubMed
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Articles related to Ocular Toxoplasmosis:

(show top 50)    (show all 353)
idTitleAuthorsYear
1
Risk factors for ocular toxoplasmosis in Brazil. (23507508)
2014
2
Case report of a neonate with ocular toxoplasmosis due to congenital infection: estimation of the percentage of ocular toxoplasmosis in Greece caused by congenital or acquired infection. (24293989)
2013
3
Corticosteroids as adjuvant therapy for ocular toxoplasmosis. (23633342)
2013
4
Imaging in ocular toxoplasmosis. (22954935)
2012
5
Epidemiology of ocular toxoplasmosis. (22409558)
2012
6
Diagnostic approach to ocular toxoplasmosis. (21770803)
2011
7
Outbreak of acquired ocular toxoplasmosis involving 248 patients. (20065213)
2010
8
Update on the treatment of ocular toxoplasmosis. (19319237)
2009
9
Anti-Toxoplasma gondii secretory IgA in tears of patients with ocular toxoplasmosis: immunodiagnostic validation by ELISA. (19876553)
2009
10
Ocular toxoplasmosis: the influence of patient age. (19430663)
2009
11
Fluorescein and indocyanine green angiography in ocular toxoplasmosis. (16673136)
2006
12
Effects of sulfamethoxazole on murine ocular toxoplasmosis in interferon-gamma knockout mice. (16384972)
2006
13
Diagnostic value of specific local antibody production and nucleic acid amplification technique-nested polymerase chain reaction (nPCR) in clinically suspected ocular toxoplasmosis. (16597540)
2006
14
Active ocular toxoplasmosis in Turkish patients: a report on 109 cases. (17318320)
2005
15
Reactivation of ocular toxoplasmosis in fellow unaffected eye. (15309981)
2004
16
Ocular toxoplasmosis: a global reassessment. Part II: disease manifestations and management. (14700638)
2004
17
Socioeconomic conditions as determining factors in the prevalence of systemic and ocular toxoplasmosis in Northeastern Brazil. (15512992)
2004
18
Fuchs' heterochromic iridocyclitis following bilateral ocular toxoplasmosis. (15209468)
2004
19
Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease. (14644206)
2003
20
A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis. (12095805)
2002
21
Ocular toxoplasmosis. (12434481)
2002
22
Evidence for a compartmentalized B cell response as characterized by IgG epitope specificity in human ocular toxoplasmosis. (11714789)
2001
23
Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with ocular toxoplasmosis. (11726627)
2001
24
Is ocular toxoplasmosis caused by prenatal or postnatal infection? (10655202)
2000
25
Early aqueous humor analysis in patients with human ocular toxoplasmosis. (10698986)
2000
26
Diagnostic value of polymerase chain reaction in blood and aqueous humor in immunocompetent patients with ocular toxoplasmosis. (11131414)
2000
27
Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice. (9916110)
1999
28
Ocular toxoplasmosis. (8028164)
1994
29
Quadruple therapy for ocular toxoplasmosis. (8508337)
1993
30
Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome. (1543229)
1992
31
Serological investigation of ocular toxoplasmosis. (2043579)
1991
32
Visual impairment and blindness in ocular toxoplasmosis cases. (1822947)
1991
33
Ocular toxoplasmosis in AIDS patients. (2095034)
1990
34
Reactivation of ocular toxoplasmosis. (2216335)
1990
35
Up-date on the treatment of ocular toxoplasmosis. (16312720)
1989
36
Ocular toxoplasmosis in patients with the acquired immunodeficiency syndrome. (3195645)
1988
37
Estimated prevalence of ocular toxoplasmosis and toxocariasis in Alabama. (3598243)
1987
38
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
39
Congenital ocular toxoplasmosis. (6827609)
1983
40
Ocular toxoplasmosis in Malaysia. (6672558)
1983
41
Ocular toxoplasmosis. (6401146)
1983
42
Treatment of ocular toxoplasmosis with clindamycin and sulfadiazine. (7383542)
1980
43
Presumed ocular toxoplasmosis: some clinical observations. (525667)
1979
44
Congenital ocular toxoplasmosis. Possible occurrence in siblings. (348171)
1978
45
Clindamycin in the treatment of human ocular toxoplasmosis. (890588)
1977
46
Ocular toxoplasmosis in an adult receiving long-term corticosteroid therapy. (1252177)
1976
47
Experimental ocular toxoplasmosis in mice: immunofluorescent demonstration of toxoplasma antigens in the early stage of infection. (4929160)
1970
48
Ocular toxoplasmosis among Negro immigrants in London. (6050875)
1967
49
A case of ocular toxoplasmosis in an adult, the infection being confirmed by the isolation of the parasite from subretinal fluid. (14471249)
1961
50
Ocular toxoplasmosis; report of cases. (13435325)
1957

Variations for Ocular Toxoplasmosis

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Expression for genes affiliated with Ocular Toxoplasmosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ocular Toxoplasmosis

Search GEO for disease gene expression data for Ocular Toxoplasmosis.

Pathways for genes affiliated with Ocular Toxoplasmosis

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Sources:
50PathCards, 5Cell Signaling Technology, 55Reactome, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 57SinoBiological, 54R&D Systems, 61Tocris Bioscience, 60Thomson Reuters
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Pathways related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TLR1, TLR9
2
Show member pathways
9.3NOD2, TLR9
3
Show member pathways
9.1TLR5, NOD2
4
Show member pathways
9.1NOD2, TLR5
58.8TLR9, NOD2, TLR1
6
Show member pathways
8.5TLR1, TLR9, TLR5
7
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5TLR5, TLR1, TLR9
8
Show member pathways
8.5TLR1, TLR5, TLR9
9
Show member pathways
8.5TLR9, TLR5, TLR1
10
Show member pathways
8.5TLR5, TLR1, TLR9
118.5TLR5, TLR1, TLR9
12
Show member pathways
8.5TLR9, TLR5, TLR1
13
Show member pathways
IL27-mediated signaling events38
8.5TLR9, TLR1, TLR5
14
Show member pathways
8.5TLR9, TLR5, TLR1
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5TLR5, TLR1, TLR9
168.5TLR1, TLR5, TLR9
17
Show member pathways
8.5TLR1, TLR5, TLR9
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.0TLR5, TLR1, NOD2, TLR9

Compounds for genes affiliated with Ocular Toxoplasmosis

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45Novoseek, 61Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1resiquimod45 6110.4TLR1, TLR9
2cytosine45 2410.2TLR9, NOD2
3loxoribine45 2910.1TLR9, TLR5
4poly(i-c)459.0TLR5, TLR9
5rantes459.0TLR5, TLR9
6endotoxin459.0NOD2, TLR9
7flagellin45 299.7TLR9, TLR1, TLR5
8lipoteichoic acid458.7TLR5, TLR1, TLR9
9peptidoglycan45 299.2NOD2, TLR5, TLR1, TLR9

GO Terms for genes affiliated with Ocular Toxoplasmosis

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16Gene Ontology
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Cellular components related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.0NOD2, TLR5, TLR1, TLR9

Biological processes related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:0302779.6NOD2, TLR9
2positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.6NOD2, TLR9
3positive regulation of interleukin-10 productionGO:0327339.6TLR9, NOD2
4positive regulation of interleukin-12 productionGO:0327359.6NOD2, TLR9
5positive regulation of tumor necrosis factor productionGO:0327609.6NOD2, TLR9
6positive regulation of interleukin-6 productionGO:0327559.5TLR9, NOD2
7positive regulation of JNK cascadeGO:0463309.5NOD2, TLR9
8negative regulation of NF-kappaB transcription factor activityGO:0320889.5NOD2, TLR9
9positive regulation of toll-like receptor signaling pathwayGO:0341239.3TLR9, TLR5
10toll-like receptor 9 signaling pathwayGO:0341629.3NOD2, TLR9
11positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3NOD2, TLR9
12positive regulation of interleukin-8 productionGO:0327579.3TLR5, TLR9
13toll-like receptor 10 signaling pathwayGO:0341669.2TLR5, NOD2
14defense response to bacteriumGO:0427429.2TLR9, NOD2
15toll-like receptor 5 signaling pathwayGO:0341469.2TLR5, NOD2
16positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, TLR9
17MyD88-dependent toll-like receptor signaling pathwayGO:0027558.8TLR9, TLR5, NOD2
18inflammatory responseGO:0069548.8TLR9, TLR1, TLR5
19toll-like receptor signaling pathwayGO:0022248.3NOD2, TLR5, TLR1, TLR9
20innate immune responseGO:0450878.3NOD2, TLR5, TLR1, TLR9

Molecular functions related to Ocular Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.3TLR1, TLR9
2interleukin-1 receptor bindingGO:0051498.7TLR5, TLR9

Products for genes affiliated with Ocular Toxoplasmosis

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Sources for Ocular Toxoplasmosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet