MCID: ODN005
MIFTS: 38

Odontogenic Myxoma malady

Summaries for Odontogenic Myxoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 The odontogenic myxoma is an uncommon benign odontogenic tumor arising from embryonic connective tissue... more...

MalaCards: Odontogenic Myxoma is related to tuberous sclerosis and granular cell tumor. An important gene associated with Odontogenic Myxoma is PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha), and among its related pathways are Colorectal Cancer Metastasis and CS/DS degradation. The compounds procollagen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, and related mouse phenotypes are limbs/digits/tail and homeostasis/metabolism.

Aliases & Classifications for Odontogenic Myxoma

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

odontogenic myxoma 43 61


Related Diseases for Odontogenic Myxoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Odontogenic Myxoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1tuberous sclerosis30.2S100B, VIM
2granular cell tumor30.2S100B, VIM
3basal cell carcinoma30.2DCN, BAK1, MMP1
4nevoid basal cell carcinoma syndrome10.2
5n syndrome10.2
6basal cell carcinoma, multiple10.2
7nevo syndrome10.2
8papilloma10.0BAK1
9ischemia10.0BAK1
10retinoblastoma10.0BAK1
11paraganglioma10.0S100B
12myositis10.0SERPINA3
13multiple epiphyseal dysplasia10.0ACAN
14glomerulonephritis10.0DCN
15pheochromocytoma10.0GNAS
16myopia 610.0DCN
17bronchiectasis10.0SERPINA3
18spondylitis10.0ACAN
19gingivitis10.0MMP1
20dilated cardiomyopathy10.0MMP1
21dementia10.0SERPINA3
22oral submucous fibrosis10.0MMP1
23glaucoma10.0MMP1
24primary hyperoxaluria10.0MMP2
25brachydactyly10.0GNAS
26histiocytosis10.0S100B
27psoriasis10.0BAK1, SERPINA3
28hypercalcemia10.0PRKAR1A
29insulin resistance10.0GNAS
30fibromatosis10.0VIM
31osteochondritis dissecans10.0ACAN
32rosai-dorfman disease10.0S100B
33thyroid cancer10.0PRKAR1A, GNAS
34carney complex10.0PRKAR1A, GNAS
35myocardial infarction10.0DCN, SERPINA3
36malignant mesothelioma10.0VIM
37sarcoidosis10.0SERPINA3, DCN
38down syndrome10.0S100B, SERPINA3
39acrodysostosis10.0GNAS, PRKAR1A
40medulloblastoma10.0S100B, VCAN
41leukemia10.0SERPINA3, BAK1
42wilms tumor10.0VIM
43laryngeal carcinoma10.0BAK1, MMP2
44synovitis10.0ACAN, MMP1
45leiomyoma10.0S100B, VIM
46hepatitis b10.0BAK1
47chordoma10.0VIM, S100B
48ovarian cyst10.0CNC, GNAS
49pituitary adenoma10.0GNAS, PRKAR1A, CNC
50dermatofibrosarcoma protuberans10.0S100B, VIM

Graphical network of the top 20 diseases related to Odontogenic Myxoma:



Diseases related to odontogenic myxoma

Clinical Features for Odontogenic Myxoma

Drugs & Therapeutics for Odontogenic Myxoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Odontogenic Myxoma

Drug clinical trials:

Search ClinicalTrials for Odontogenic Myxoma

Search NIH Clinical Center for Odontogenic Myxoma

Search CenterWatch for Odontogenic Myxoma

Genetic Tests for Odontogenic Myxoma

Anatomical Context for Odontogenic Myxoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Odontogenic Myxoma:

33
Smooth muscle

Animal Models for Odontogenic Myxoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Odontogenic Myxoma

Sources:
51PubMed
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Articles related to Odontogenic Myxoma:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Synchronous occurrence of odontogenic myxoma with multiple keratocystic odontogenic tumors in nevoid basal cell carcinoma syndrome. (24163866)
2013
2
The imaging characteristics of odontogenic myxoma and a comparison of three different imaging modalities. (23972779)
2013
3
Infiltrative odontogenic myxoma of the posterior maxilla: Report of a case. (24082760)
2013
4
The orosomucoid 1 protein (I+1 acid glycoprotein) is overexpressed in odontogenic myxoma. (22888844)
2012
5
Spontaneous bone regeneration following mandibular resection for odontogenic myxoma. (22684138)
2012
6
Oral pathology quiz #77. Case number 3. Odontogenic myxoma. (23342740)
2012
7
Odontogenic myxoma of the mandible. (22830060)
2012
8
Molecular review of odontogenic myxoma. (21444236)
2011
9
Odontogenic myxoma of the maxilla: A report of a rare case and review on histogenetic and diagnostic concepts. (22639512)
2011
10
A clinico-pathologic correlation. Odontogenic myxoma. (20806706)
2010
11
Odontogenic myxoma of the maxilla: A report of a rare case and review of the literature. (21180454)
2010
12
Odontogenic myxoma: Report of two cases. (22442596)
2010
13
Condyloma acuminatum associated with odontogenic myxoma: a case report. (23139551)
2009
14
Oral pathology quiz #63. Case number 3. Least likely odontogenic myxoma. (19753670)
2009
15
Odontogenic myxoma of maxilla. (18245926)
2008
16
Recurrent odontogenic myxoma of maxilla: a diagnostic and operative dilemma. (23120497)
2008
17
Odontogenic myxoma--a case report and clinico-radiographic study of seven tumors. (16491154)
2006
18
Mandibular odontogenic myxoma. Reconstructive considerations by means of the vascularized fibular free flap. (17072260)
2006
19
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas. (16001434)
2005
20
A rare case of odontogenic myxoma in a dog. (16176569)
2005
21
Application of a surgical navigation system for implant surgery in a deficient alveolar ridge postexcision of an odontogenic myxoma. (16003627)
2005
22
Oral pathology quiz # 42. Case 3. Odontogenic myxoma. (15160432)
2004
23
Oral pathology quiz # 39. Case 1. Odontogenic myxoma. (12861649)
2003
24
Odontogenic myxoma of the maxilla: a report of two pediatric cases. (12663111)
2003
25
Comparison of radiographic and MRI features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots. (12945597)
2003
26
Maxillary odontogenic myxoma: a diagnostic pitfall on aspiration cytology. (12203879)
2002
27
Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF). (11545240)
2001
28
Odontogenic myxoma of maxillary sinus: CT and MR-pathologic correlation. (11274831)
2001
29
A novel cell line that retains the morphological characteristics of the cells and matrix of odontogenic myxoma. (10738940)
2000
30
Odontogenic myxoma of the mandible in a filly. (10353360)
1999
31
Odontogenic myxoma. (10587272)
1999
32
Odontogenic myxoma: case report with reconstructive considerations. (9775463)
1998
33
Management of odontogenic myxoma of the maxilla. (9419108)
1997
34
Clinical and radiological features of odontogenic myxoma of the jaws. (9482003)
1997
35
Odontogenic myxoma of the jaws: a clinical, radiologic, immunohistochemical, and ultrastructural study. (8899782)
1996
36
Odontogenic myxoma--a radiographic study of 21 tumours. (7999737)
1994
37
Odontogenic myxoma: report of two cases with reconstruction considerations. (8336234)
1993
38
Odontogenic myxoma. Report of a periodontally-located case. (1870069)
1991
39
Proper treatment of odontogenic myxoma. (2709229)
1989
40
Odontogenic myxoma of the maxilla. (3108815)
1987
41
Treatment of odontogenic myxoma. Review of the literature and report of three cases. (3326514)
1987
42
Childhood odontogenic myxoma: report of two cases. (3859846)
1985
43
Odontogenic myxoma. (6438008)
1984
44
Odontogenic myxoma. Surgical management and an ultrastructural study. (283350)
1979
45
Clinical-pathological conference: Case 24, Part 1. Odontogenic myxoma. (277654)
1978
46
Maxillary resection for odontogenic myxoma: report of case. (267173)
1977
47
Ultrastructural study of an odontogenic myxoma. (1066602)
1976
48
Ultrastructure of an odontogenic myxoma. (163999)
1975
49
Odontogenic myxoma: ultrastructural and histochemical studies. (4354841)
1973
50
Odontogenic myxoma of the jaw. (14489722)
1962

Genetic Variations for Odontogenic Myxoma

Expression for genes affiliated with Odontogenic Myxoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Odontogenic Myxoma

Search GEO for disease gene expression data for Odontogenic Myxoma.

Pathways for genes affiliated with Odontogenic Myxoma

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems
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Pathways related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAR1A, MMP1
2
Hide members
9.9DCN, VCAN
39.6MMP9, MMP1
4
Hide members
9.1VCAN, ACAN, CD36, DCN
5
Cell adhesion Cell-matrix glycoconjugates
Hide members
9.0VCAN, ACAN, MMP9, MMP1
69.0VCAN, MMP9, MMP2
79.0VCAN, MMP2, BAK1
8
Hide members
9.0MMP2, MMP1, MMP9
99.0VIM, MMP9, ACAN, VCAN
108.9MMP9, MMP2, CD36
118.7DCN, MMP2, MMP1, MMP9
12
Cell adhesion ECM remodeling
Hide members
8.4MMP2, MMP1, MMP9, ACAN, VCAN
13
Hide members
7.9COL14A1, PRKAR1A, CD36, MMP2, MMP1, MMP9
14
Hide members
7.7VCAN, ACAN, MMP9, MMP1, MMP2, DCN

Compounds for genes affiliated with Odontogenic Myxoma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1procollagen4510.7ACAN
2glutamate4510.4PRKAR1A, GNAS
3dermatan45 2411.1VCAN, ACAN
4dermatan sulfate4510.0ACAN, VCAN, DCN
5cilomilast459.9MMP1, MMP9
6neurocan459.8DCN, VCAN, ACAN
7hydroxyapatite459.8DCN, S100B, CD36
8alginate459.6CD36, DCN, ACAN, VCAN
9keratan sulfate459.6VCAN, ACAN, CD36, DCN
10pge2459.5MMP2, MMP9, ACAN
11cgs-27023a459.4MMP9, MMP2, MMP1
12prinomastat459.4MMP9, MMP1, MMP2
13ilomastat459.3MMP2, MMP9, MMP1
14latanoprost45 1110.3MMP9, MMP1, MMP2
15hematoxylin459.3MMP9, VIM, S100B, MMP1
16glucose459.3SERPINA3, BAK1, VCAN
17chondroitin sulfate45 2410.1VCAN, DCN, CD36, ACAN, VIM
18heparin45 29 11 2412.1VCAN, DCN, S100B, SERPINA3, CD36
19dexamethasone45 50 29 1112.1MMP9, BAK1, DCN, S100B, ACAN
20gm 6001609.0MMP2, MMP9, MMP1
21leucine459.0GNAS, S100B, VIM, ACAN, SERPINA3, DCN
223-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide458.9S100B, BAK1, MMP9, MMP2
23zoledronic acid458.9MMP2, CD36, MMP9, MMP1
24batimastat45 60 1110.9MMP2, CD36, MMP1, MMP9
25pioglitazone45 50 29 1111.8MMP1, MMP2, CD36, MMP9
26ag 1478458.7MMP2, MMP9, BAK1, DCN
27celecoxib45 60 29 50 11 2413.7MMP2, MMP1, BAK1, MMP9
28glycosaminoglycan458.7VCAN, CD36, MMP1, ACAN, DCN, MMP9
29gi 254023x608.7MMP2, MMP1, MMP9
30ascorbic acid45 249.7S100B, ACAN, MMP2, CD36, MMP1
31hydroxyproline45 11 2410.7MMP2, DCN, MMP9, CD36, MMP1
32vitamin a45 11 2410.6VIM, MMP2, SERPINA3, MMP9, MMP1
33methotrexate45 50 1110.6VIM, MMP2, MMP1, MMP9, SERPINA3
34ribonucleic acid458.6GNAS, DCN, MMP2, MMP1, MMP9
35serine458.5MMP2, SERPINA3, S100B, GNAS, MMP1, MMP9
36cytochalasin d45 609.5MMP9, MMP1, CD36, VIM, MMP2
37creatinine458.4DCN, CD36, SERPINA3, MMP9, MMP1, MMP2
38troglitazone45 29 60 1111.4MMP2, MMP9, CD36, MMP1, BAK1
39progesterone45 60 29 11 2412.3MMP1, VIM, S100B, GNAS, MMP2, SERPINA3
40sb 20358045 609.3MMP2, ACAN, MMP1, CD36, VIM, MMP9
41matrigel458.2MMP9, VIM, DCN, CD36, MMP2, MMP1
42genistein45 29 60 2 11 2413.2VIM, DCN, CD36, MMP1, MMP9, MMP2
4312-o-tetradecanoylphorbol 13-acetate458.1VIM, MMP1, MMP2, BAK1, MMP9
44alanine457.7BAK1, DCN, GNAS, S100B, SERPINA3, VIM
45tgf beta1457.7DCN, VCAN, MMP2, MMP9, MMP1, CD36
46vegf457.7MMP2, VCAN, CD36, DCN, S100B, MMP1
47hyaluronic acid45 248.3MMP2, MMP1, COL14A1, VIM, DCN, CD36
48paraffin457.2DCN, S100B, BAK1, VIM, SERPINA3, MMP1
49retinoic acid45 248.0MMP2, DCN, VIM, SERPINA3, BAK1, S100B
50cysteine456.7VIM, S100B, GNAS, PRKAR1A, BAK1, CD36

GO Terms for genes affiliated with Odontogenic Myxoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6DCN, ACAN, VCAN
2lysosomal lumenGO:0432029.3VCAN, ACAN, DCN
3extracellular matrixGO:0310129.1COL14A1, DCN, ACAN, VCAN
4proteinaceous extracellular matrixGO:0055788.1COL14A1, MMP2, MMP1, MMP9, ACAN, VCAN
5extracellular spaceGO:0056157.8COL14A1, S100B, DCN, MMP2, MMP9, VCAN
6extracellular regionGO:0055767.1SERPINA3, COL14A1, S100B, GNAS, DCN, MMP2

Biological processes related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dermatan sulfate biosynthetic processGO:0302089.9DCN, VCAN
2chondroitin sulfate catabolic processGO:0302079.8DCN, VCAN
3glycosaminoglycan metabolic processGO:0302039.3DCN, ACAN, VCAN
4collagen catabolic processGO:0305748.7MMP2, MMP1, COL14A1, MMP9
5extracellular matrix disassemblyGO:0226178.7MMP9, COL14A1, MMP2, MMP1
6small molecule metabolic processGO:0442818.6PRKAR1A, DCN, CD36, ACAN, VCAN, GNAS
7extracellular matrix organizationGO:0301987.9MMP2, DCN, MMP1, MMP9, ACAN, VCAN

Molecular functions related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan bindingGO:0055399.9VCAN, DCN
2collagen bindingGO:0055189.2MMP9, DCN, COL14A1
3metalloendopeptidase activityGO:0042228.7MMP9, MMP1, MMP2

Products for genes affiliated with Odontogenic Myxoma

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  • Proteins
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Sources for Odontogenic Myxoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet