MCID: ODN005
MIFTS: 33

Odontogenic Myxoma malady

Summaries for Odontogenic Myxoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 The odontogenic myxoma is an uncommon benign odontogenic tumor arising from embryonic connective tissue... more...

MalaCards: Odontogenic Myxoma is related to gingivitis and periodontitis. An important gene associated with Odontogenic Myxoma is PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha), and among its related pathways are Colorectal Cancer Metastasis and CS/DS degradation. The compounds procollagen and glutamate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and homeostasis/metabolism.

Aliases & Classifications for Odontogenic Myxoma

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

odontogenic myxoma 42 60


Related Diseases for Odontogenic Myxoma

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17GeneCards, 18GeneDecks
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Diseases related to Odontogenic Myxoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1gingivitis30.4MMP1
2periodontitis30.4MMP1, MMP9, CD36
3tuberous sclerosis30.2S100B, VIM
4granular cell tumor30.2S100B, VIM
5basal cell carcinoma30.2DCN, BAK1, MMP1
6pericoronitis10.1
7nevoid basal cell carcinoma syndrome10.1
8papilloma10.0BAK1
9ischemia10.0BAK1
10retinoblastoma10.0BAK1
11paraganglioma10.0S100B
12myositis10.0SERPINA3
13multiple epiphyseal dysplasia10.0ACAN
14glomerulonephritis10.0DCN
15pheochromocytoma10.0GNAS
16myopia 610.0DCN
17bronchiectasis10.0SERPINA3
18spondylitis10.0ACAN
19dilated cardiomyopathy10.0MMP1
20dementia10.0SERPINA3
21oral submucous fibrosis10.0MMP1
22glaucoma10.0MMP1
23primary hyperoxaluria10.0MMP2
24brachydactyly10.0GNAS
25histiocytosis10.0S100B
26psoriasis10.0BAK1, SERPINA3
27hypercalcemia10.0PRKAR1A
28insulin resistance10.0GNAS
29fibromatosis10.0VIM
30osteochondritis dissecans10.0ACAN
31rosai-dorfman disease10.0S100B
32thyroid cancer10.0PRKAR1A, GNAS
33carney complex10.0PRKAR1A, GNAS
34myocardial infarction10.0DCN, SERPINA3
35malignant mesothelioma10.0VIM
36sarcoidosis10.0SERPINA3, DCN
37down syndrome10.0S100B, SERPINA3
38acrodysostosis10.0GNAS, PRKAR1A
39medulloblastoma10.0S100B, VCAN
40leukemia10.0SERPINA3, BAK1
41wilms tumor10.0VIM
42laryngeal benign neoplasm10.0BAK1, MMP2
43synovitis10.0ACAN, MMP1
44leiomyoma10.0S100B, VIM
45hepatitis b10.0BAK1
46chordoma10.0VIM, S100B
47ovarian cyst10.0CNC, GNAS
48pituitary adenoma10.0GNAS, PRKAR1A, CNC
49dermatofibrosarcoma protuberans10.0S100B, VIM
50leiomyosarcoma10.0VIM, S100B

Graphical network of the top 20 diseases related to Odontogenic Myxoma:



Diseases related to odontogenic myxoma

Clinical Features for Odontogenic Myxoma

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Drugs & Therapeutics for Odontogenic Myxoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Odontogenic Myxoma

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Anatomical Context for Odontogenic Myxoma

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Animal Models for Odontogenic Myxoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Odontogenic Myxoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.9VCAN, ACAN
2MP:00053769.1GNAS, PRKAR1A, DCN, CD36, ACAN
3MP:00053858.7VIM, GNAS, PRKAR1A, CD36, ACAN
4MP:00053888.5GNAS, PRKAR1A, DCN, MMP2, MMP9, ACAN
5MP:00028738.2S100B, GNAS, PRKAR1A, BAK1, MMP2, ACAN
6MP:00053918.0VIM, PRKAR1A, DCN, CD36, MMP2, MMP9
7MP:00053698.0COL14A1, PRKAR1A, DCN, CD36, MMP2, MMP9
8MP:00053867.6VIM, S100B, GNAS, DCN, BAK1, CD36
9MP:00053787.4GNAS, PRKAR1A, DCN, CD36, MMP2, MMP9
10MP:00036317.2VIM, GNAS, BAK1, CD36, MMP2, MMP9
11MP:00053877.1VIM, GNAS, PRKAR1A, DCN, BAK1, CD36
12MP:00053906.9VCAN, COL14A1, GNAS, PRKAR1A, DCN, BAK1
13MP:00107686.6VIM, GNAS, PRKAR1A, DCN, BAK1, CD36

Publications for Odontogenic Myxoma

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Genetic Variations for Odontogenic Myxoma

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Expression for genes affiliated with Odontogenic Myxoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Odontogenic Myxoma

Search GEO for disease gene expression data for Odontogenic Myxoma.

Pathways for genes affiliated with Odontogenic Myxoma

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems
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Pathways related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PRKAR1A, MMP1
2
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9.9DCN, VCAN
39.6MMP9, MMP1
4
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9.1VCAN, ACAN, CD36, DCN
5
Cell adhesion Cell-matrix glycoconjugates
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9.0VCAN, ACAN, MMP9, MMP1
69.0VCAN, MMP9, MMP2
79.0VCAN, MMP2, BAK1
8
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9.0MMP2, MMP1, MMP9
99.0VIM, MMP9, ACAN, VCAN
108.9MMP9, MMP2, CD36
118.7DCN, MMP2, MMP1, MMP9
12
Cell adhesion ECM remodeling
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8.4MMP2, MMP1, MMP9, ACAN, VCAN
13
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7.9COL14A1, PRKAR1A, CD36, MMP2, MMP1, MMP9
14
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7.7VCAN, ACAN, MMP9, MMP1, MMP2, DCN

Compounds for genes affiliated with Odontogenic Myxoma

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1procollagen4410.7ACAN
2glutamate4410.4PRKAR1A, GNAS
3dermatan44 2411.1VCAN, ACAN
4dermatan sulfate4410.0ACAN, VCAN, DCN
5cilomilast449.9MMP1, MMP9
6neurocan449.8DCN, VCAN, ACAN
7hydroxyapatite449.8DCN, S100B, CD36
8alginate449.6CD36, DCN, ACAN, VCAN
9keratan sulfate449.6VCAN, ACAN, CD36, DCN
10pge2449.5MMP2, MMP9, ACAN
11cgs-27023a449.4MMP9, MMP2, MMP1
12prinomastat449.4MMP9, MMP1, MMP2
13ilomastat449.3MMP2, MMP9, MMP1
14latanoprost44 1110.3MMP9, MMP1, MMP2
15hematoxylin449.3MMP9, VIM, S100B, MMP1
16glucose449.3SERPINA3, BAK1, VCAN
17chondroitin sulfate44 2410.1VCAN, DCN, CD36, ACAN, VIM
18heparin44 28 11 2412.1VCAN, DCN, S100B, SERPINA3, CD36
19dexamethasone44 49 28 1112.1MMP9, BAK1, DCN, S100B, ACAN
20gi 254023x599.0MMP2, MMP9, MMP1
21leucine449.0GNAS, S100B, VIM, ACAN, SERPINA3, DCN
223-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide448.9S100B, BAK1, MMP9, MMP2
23zoledronic acid448.9MMP2, CD36, MMP9, MMP1
24batimastat44 59 1110.9MMP2, CD36, MMP1, MMP9
25pioglitazone44 49 28 1111.8MMP1, MMP2, CD36, MMP9
26ag 1478448.7MMP2, MMP9, BAK1, DCN
27celecoxib44 59 28 49 11 2413.7MMP2, MMP1, BAK1, MMP9
28glycosaminoglycan448.7VCAN, CD36, MMP1, ACAN, DCN, MMP9
29uk 383367598.7MMP2, MMP1, MMP9
30ascorbic acid44 249.7S100B, ACAN, MMP2, CD36, MMP1
31hydroxyproline44 11 2410.7MMP2, DCN, MMP9, CD36, MMP1
32vitamin a44 11 2410.6VIM, MMP2, SERPINA3, MMP9, MMP1
33methotrexate44 49 1110.6VIM, MMP2, MMP1, MMP9, SERPINA3
34ribonucleic acid448.6GNAS, DCN, MMP2, MMP1, MMP9
35serine448.5MMP2, SERPINA3, S100B, GNAS, MMP1, MMP9
36cytochalasin d44 599.5MMP9, MMP1, CD36, VIM, MMP2
37creatinine448.4DCN, CD36, SERPINA3, MMP9, MMP1, MMP2
38troglitazone44 28 59 1111.4MMP2, MMP9, CD36, MMP1, BAK1
39progesterone44 59 28 11 2412.3MMP1, VIM, S100B, GNAS, MMP2, SERPINA3
40sb 20358044 599.3MMP2, ACAN, MMP1, CD36, VIM, MMP9
41matrigel448.2MMP9, VIM, DCN, CD36, MMP2, MMP1
42genistein44 28 59 2 11 2413.2VIM, DCN, CD36, MMP1, MMP9, MMP2
4312-o-tetradecanoylphorbol 13-acetate448.1VIM, MMP1, MMP2, BAK1, MMP9
44alanine447.7BAK1, DCN, GNAS, S100B, SERPINA3, VIM
45tgf beta1447.7DCN, VCAN, MMP2, MMP9, MMP1, CD36
46vegf447.7MMP2, VCAN, CD36, DCN, S100B, MMP1
47hyaluronic acid44 248.3MMP2, MMP1, COL14A1, VIM, DCN, CD36
48paraffin447.2DCN, S100B, BAK1, VIM, SERPINA3, MMP1
49retinoic acid44 248.0MMP2, DCN, VIM, SERPINA3, BAK1, S100B
50cysteine446.7VIM, S100B, GNAS, PRKAR1A, BAK1, CD36

GO Terms for genes affiliated with Odontogenic Myxoma

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16Gene Ontology
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Cellular components related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6VCAN, ACAN, DCN
2lysosomal lumenGO:0432029.3VCAN, ACAN, DCN
3extracellular matrixGO:0310129.1COL14A1, DCN, ACAN, VCAN
4proteinaceous extracellular matrixGO:0055788.1COL14A1, MMP2, MMP1, MMP9, ACAN, VCAN
5extracellular spaceGO:0056157.8COL14A1, S100B, DCN, MMP2, MMP9, VCAN
6extracellular regionGO:0055767.1SERPINA3, COL14A1, S100B, GNAS, DCN, MMP2

Biological processes related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dermatan sulfate biosynthetic processGO:0302089.9VCAN, DCN
2chondroitin sulfate catabolic processGO:0302079.8VCAN, DCN
3glycosaminoglycan metabolic processGO:0302039.3DCN, ACAN, VCAN
4collagen catabolic processGO:0305748.7MMP9, MMP1, MMP2, COL14A1
5extracellular matrix disassemblyGO:0226178.7COL14A1, MMP2, MMP1, MMP9
6small molecule metabolic processGO:0442818.6VCAN, ACAN, CD36, DCN, PRKAR1A, GNAS
7extracellular matrix organizationGO:0301987.9VCAN, COL14A1, DCN, MMP2, MMP1, MMP9

Molecular functions related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan bindingGO:0055399.9VCAN, DCN
2collagen bindingGO:0055189.2MMP9, DCN, COL14A1
3metalloendopeptidase activityGO:0042228.7MMP9, MMP1, MMP2

Products for genes affiliated with Odontogenic Myxoma

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Sources for Odontogenic Myxoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet