MCID: ODN005
MIFTS: 45

Odontogenic Myxoma malady

Rare diseases category
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Summaries for Odontogenic Myxoma

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Wikipedia:65 The odontogenic myxoma is an uncommon benign odontogenic tumor arising from embryonic connective tissue... more...

MalaCards based summary: Odontogenic Myxoma is related to periodontitis and granular cell tumor. An important gene associated with Odontogenic Myxoma is ACAN (aggrecan), and among its related pathways are Articular Cartilage Extracellular Matrix and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds keratan sulfate and dermatan sulfate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Odontogenic Myxoma

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Odontogenic Myxoma, Aliases & Descriptions:

Name: Odontogenic Myxoma 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Odontogenic Myxoma

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Diseases related to Odontogenic Myxoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis30.9MMP9
2granular cell tumor30.8S100B, VIM
3basal cell carcinoma30.7BAK1, MMP1, DCN
4multiple epiphyseal dysplasia10.6ACAN
5syringoma10.6S100B
6osteochondritis dissecans10.6ACAN
7rosai-dorfman disease10.5S100B
8fibromatosis10.5VIM
9adenomatoid tumor10.4VIM
10paraganglioma10.4VIM
11synovitis10.4ACAN, MMP1
12creutzfeldt-jakob disease10.4SERPINA3, S100B
13meningioma10.3VIM, S100B
14spindle cell sarcoma10.3VIM, S100B
15fibroma10.3
16marfan syndrome10.3CD36, DCN
17myoepithelioma10.3S100B, VIM
18dermatofibrosarcoma protuberans10.3S100B, VIM
19perineurioma10.3S100B, VIM
20sex cord-gonadal stromal tumor10.3S100B, VIM
21epidermolysis bullosa dystrophica10.3CD36, MMP1
22hemangiopericytoma10.3S100B, VIM
23progressive osseous heteroplasia10.3GNAS, DCN
24hypertensive heart disease10.3CD36, MMP1
25malignant mixed mullerian tumor10.3S100B, VIM
26chordoma10.3S100B, VIM
27arthropathy10.3ACAN, DCN, MMP1
28smooth muscle tumor10.3VIM, S100B
29angiosarcoma10.3SERPINA3, VIM
30malignant peripheral nerve sheath tumor10.3S100B, VIM
31mccune albright syndrome10.3GNAS, PRKAR1A
32acrodysostosis10.3PRKAR1A, GNAS
33osteofibrous dysplasia10.3GNAS, CD36
34skeletal dysplasia multi-gene panels10.3ACAN, GNAS
35pseudoachondroplasia10.3DCN, ACAN, CD36
36ehlers-danlos syndrome10.3DCN, CD36
37carney complex10.3GNAS, PRKAR1A
38short stature10.2GNAS, CD36
39thoracic aortic aneurysm10.2MMP1, MMP2
40liver cirrhosis10.2SERPINA3, DCN, COL14A1
41secondary hyperparathyroidism of renal origin10.2CD36, PRKAR1A
42primary hyperparathyroidism10.2CD36, PRKAR1A
43fibrous histiocytoma10.2SERPINA3, VIM, S100B
44malignant fibroxanthoma10.2S100B, SERPINA3, VIM
45adrenal adenoma10.2PRKAR1A, GNAS
46salivary gland adenoid cystic carcinoma10.2S100B, VIM, SERPINA3
47parathyroid adenoma10.2GNAS, PRKAR1A
48osteogenesis imperfecta10.2CD36, DCN
49lymphangioleiomyomatosis10.2MMP1, MMP2
50ameloblastoma10.2SERPINA3, MMP2

Graphical network of the top 20 diseases related to Odontogenic Myxoma:



Diseases related to odontogenic myxoma

Symptoms for Odontogenic Myxoma

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Drugs & Therapeutics for Odontogenic Myxoma

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Drug clinical trials:

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Genetic Tests for Odontogenic Myxoma

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Anatomical Context for Odontogenic Myxoma

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MalaCards organs/tissues related to Odontogenic Myxoma:

32
Bone

Animal Models for Odontogenic Myxoma or affiliated genes

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Publications for Odontogenic Myxoma

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Articles related to Odontogenic Myxoma:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Infant Odontogenic Myxoma: A specific entity. (24429059)
2014
2
A large odontogenic myxoma of the bilateral maxillae: A case report. (25120718)
2014
3
Odontogenic Myxoma: a study based on biopsy material over a 40-year period. (25095832)
2014
4
Surgical treatment of odontogenic myxoma and facial deformity in the same procedure. (24124313)
2013
5
An ectopic tooth concealing an odontogenic myxoma. (23505856)
2013
6
Synchronous occurrence of odontogenic myxoma with multiple keratocystic odontogenic tumors in nevoid basal cell carcinoma syndrome. (24163866)
2013
7
The imaging characteristics of odontogenic myxoma and a comparison of three different imaging modalities. (23972779)
2013
8
Using the condylar prosthesis after resection of a large odontogenic myxoma tumor in the mandible. (22976683)
2012
9
Dental pulp stem cells express proteins involved in the local invasiveness of odontogenic myxoma. (22473349)
2012
10
Conservative treatment of odontogenic myxoma. (21959474)
2011
11
Hypomethylation of tumor suppressor genes in odontogenic myxoma. (22011900)
2011
12
A clinico-pathologic correlation. Odontogenic myxoma. (20806706)
2010
13
Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro. (18587209)
2008
14
Odontogenic myxoma of maxilla. (18245926)
2008
15
Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. (17996487)
2008
16
Pediatric maxillary odontogenic myxoma: a report of 2 cases and review of management. (18423302)
2008
17
Problems in diagnosing odontogenic myxoma: case report. (17600984)
2007
18
Odontogenic myxoma of the maxilla: a case report. (18187991)
2007
19
Odontogenic myxoma of the maxilla. (17915662)
2007
20
A rare case of odontogenic myxoma in a dog. (16176569)
2005
21
Application of a surgical navigation system for implant surgery in a deficient alveolar ridge postexcision of an odontogenic myxoma. (16003627)
2005
22
Computed tomography of odontogenic myxoma. (15037142)
2004
23
Oral pathology quiz # 42. Case 3. Odontogenic myxoma. (15160432)
2004
24
Cytologic features of odontogenic myxoma. (15471259)
2004
25
Oral and maxillofacial pathology case of the month. Odontogenic myxoma. (12889417)
2003
26
Oral pathology quiz # 39. Case 1. Odontogenic myxoma. (12861649)
2003
27
Computed tomography of odontogenic myxoma. (12917281)
2003
28
Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF). (11545240)
2001
29
Odontogenic myxoma of maxillary sinus: CT and MR-pathologic correlation. (11274831)
2001
30
Immunohistochemical and histochemical characterization of the mucosubstances of odontogenic myxoma: histogenesis and differential diagnosis. (10399179)
1999
31
Odontogenic myxoma of the mandible in a filly. (10353360)
1999
32
Odontogenic myxoma. (10587272)
1999
33
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene. (9891502)
1998
34
Odontogenic myxoma: case report with reconstructive considerations. (9775463)
1998
35
Management of odontogenic myxoma of the maxilla. (9419108)
1997
36
Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the tumour stroma. (7536506)
1994
37
Odontogenic myxoma of the mandible. Report of a case and review of the literature. (7942346)
1994
38
Maxillary odontogenic myxoma. A case report. (7808718)
1994
39
Odontogenic myxoma: report of two cases with reconstruction considerations. (8336234)
1993
40
Odontogenic myxoma: histochemical and ultrastructural study. (1432734)
1992
41
Re: Odontogenic myxoma. Report of a periodontally-located case. (1622487)
1992
42
Odontogenic myxoma: an orthodontic presentation. (1910983)
1991
43
Odontogenic myxoma: report of a case with peculiar features. (1985190)
1991
44
Proper treatment of odontogenic myxoma. (2709229)
1989
45
Odontogenic myxoma: report of a case. (3294359)
1988
46
Childhood odontogenic myxoma: report of two cases. (3859846)
1985
47
Odontogenic myxoma of the maxilla. (891433)
1977
48
Ultrastructural study of an odontogenic myxoma. (1066602)
1976
49
Odontogenic myxoma: some histochemical considerations. (4163678)
1965
50
Odontogenic myxoma--mandible. (5214714)
1965

Variations for Odontogenic Myxoma

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Expression for genes affiliated with Odontogenic Myxoma

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Expression patterns in normal tissues for genes affiliated with Odontogenic Myxoma

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Pathways for genes affiliated with Odontogenic Myxoma

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Pathways related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ACAN, DCN
29.9SERPINA3, MMP1
39.7DCN, VCAN, ACAN
49.6MMP2, MMP1
59.5MMP9, MMP1
69.3MMP9, MMP2
79.3MMP2, MMP9
89.3MMP2, MMP9
99.3GNAS, PRKAR1A
109.1BAK1, MMP2, VCAN
119.0MMP2, MMP9, DCN
129.0MMP2, VCAN, MMP9
13
Show member pathways
Signaling Pathways in Glioblastoma37
9.0MMP2, MMP1, MMP9
14
Show member pathways
9.0MMP2, MMP9, MMP1
159.0VCAN, MMP9, ACAN, MMP1
168.9CD36, MMP2, MMP9
178.9VIM, VCAN, ACAN, MMP9
188.7MMP1, MMP2, DCN, MMP9
19
Show member pathways
8.6MMP2, MMP1, PRKAR1A, MMP9
208.6MMP9, MMP2, MMP1, PRKAR1A
21
Show member pathways
8.5MMP1, CD36, PRKAR1A, GNAS
22
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5MMP2, GNAS, MMP9
23
Show member pathways
8.4MMP9, VCAN, ACAN, MMP2, MMP1
24
Show member pathways
8.4MMP9, BAK1, MMP2, PRKAR1A
25
Show member pathways
8.0CD36, GNAS, PRKAR1A, VCAN, DCN, ACAN
26
Show member pathways
7.9MMP9, PRKAR1A, MMP2, CD36, COL14A1, MMP1
27
Show member pathways
7.8MMP9, COL14A1, DCN, VCAN, MMP2, ACAN

Compounds for genes affiliated with Odontogenic Myxoma

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Compounds related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1keratan sulfate449.6VCAN, ACAN, DCN, CD36
2dermatan sulfate449.4DCN, CD36, VIM, VCAN
3cgs-27023a449.4MMP2, MMP1, MMP9
4prinomastat449.3MMP1, MMP2, MMP9
5ilomastat449.3MMP9, MMP1, MMP2
6hydroxyapatite449.3CD36, VIM, DCN, S100B
7latanoprost44 1110.3MMP1, MMP9, MMP2
8cilomilast449.3MMP9, MMP1, MMP2
9chondroitin sulfate44 2410.2DCN, VIM, ACAN, CD36, VCAN
10alginate449.1MMP2, VCAN, ACAN, DCN, CD36
11hematoxylin449.1S100B, VIM, MMP1, MMP9
12(4-aminophenyl)mercuric acetate449.0MMP9, MMP2, CD36, MMP1
13zoledronic acid449.0MMP1, CD36, MMP2, MMP9
14batimastat44 61 1110.9CD36, MMP9, MMP2, MMP1
153-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide448.9S100B, BAK1, MMP9, MMP2
16heparin44 28 24 1111.8SERPINA3, VCAN, CD36, S100B, DCN, VIM
17hydroxyproline44 24 1110.7DCN, MMP9, CD36, MMP1, MMP2
18glycosaminoglycan448.7VCAN, DCN, CD36, MMP9, MMP1, ACAN
19pioglitazone28 44 50 1111.7CD36, MMP1, MMP2, MMP9
20celecoxib44 61 28 50 24 1113.6MMP9, MMP1, BAK1, MMP2
21vitamin a44 24 1110.6MMP9, VIM, MMP2, MMP1, SERPINA3
22methotrexate50 44 1110.6SERPINA3, MMP9, MMP1, MMP2, VIM
23ag 1478448.5MMP2, BAK1, MMP9, DCN
24cytochalasin d44 619.5VIM, MMP9, MMP2, CD36, MMP1
25leucine448.5DCN, S100B, ACAN, VIM, SERPINA3, GNAS
26troglitazone44 28 61 1111.4BAK1, CD36, MMP1, MMP2, MMP9
27ascorbic acid44 249.4S100B, ACAN, MMP1, CD36, MMP2
28sb 20358044 619.3MMP2, MMP9, MMP1, ACAN, VIM, CD36
29matrigel448.2CD36, MMP2, MMP9, MMP1, VIM, DCN
30genistein44 28 61 2 24 1113.2VIM, MMP9, CD36, MMP1, DCN, MMP2
3112-o-tetradecanoylphorbol 13-acetate448.0MMP9, MMP2, BAK1, MMP1, VIM
32ribonucleic acid447.9MMP1, MMP2, DCN, GNAS, MMP9
33cycloheximide447.8VIM, CD36, BAK1, MMP1, MMP2, MMP9
34glucose447.8SERPINA3, GNAS, VCAN, PRKAR1A, S100B, BAK1
35creatinine447.8S100B, CD36, MMP1, MMP9, DCN, MMP2
36tgf beta1447.7MMP1, ACAN, CD36, MMP9, VIM, VCAN
37procollagen447.7VIM, ACAN, CD36, COL14A1, MMP1, MMP2
38progesterone44 28 61 24 1111.7SERPINA3, GNAS, VIM, MMP1, S100B, MMP2
39vegf447.7S100B, VIM, MMP9, MMP2, MMP1, CD36
40pge2447.6CD36, ACAN, MMP1, MMP2, MMP9, DCN
41hyaluronic acid44 248.4DCN, VCAN, VIM, MMP9, MMP2, MMP1
42glutamate447.3GNAS, DCN, VIM, MMP2, MMP9, PRKAR1A
43paraffin447.2CD36, BAK1, S100B, MMP1, MMP2, SERPINA3
44estrogen447.2CD36, BAK1, S100B, MMP1, MMP9, VIM
45dexamethasone44 50 28 1110.1SERPINA3, DCN, S100B, MMP9, MMP1, PRKAR1A
46alanine447.1DCN, GNAS, SERPINA3, S100B, VIM, MMP9
47retinoic acid44 248.0SERPINA3, DCN, CD36, BAK1, S100B, MMP1
48serine446.9MMP2, GNAS, DCN, VIM, MMP9, MMP1
49calcium44 50 24 119.6SERPINA3, MMP2, MMP1, PRKAR1A, GNAS, MMP9
50cysteine446.0MMP2, GNAS, DCN, SERPINA3, CD36, BAK1

GO Terms for genes affiliated with Odontogenic Myxoma

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Cellular components related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7DCN, VCAN, ACAN
2lysosomal lumenGO:0432029.4ACAN, VCAN, DCN
3extracellular matrixGO:0310129.3DCN, VCAN, ACAN, COL14A1
4proteinaceous extracellular matrixGO:0055788.2VCAN, MMP9, MMP2, MMP1, ACAN, COL14A1
5extracellular spaceGO:0056158.1DCN, VCAN, S100B, COL14A1, MMP2, MMP9
6extracellular regionGO:0055766.6S100B, GNAS, DCN, SERPINA3, VCAN, MMP9

Biological processes related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dermatan sulfate biosynthetic processGO:03020810.0DCN, VCAN
2chondroitin sulfate catabolic processGO:03020710.0VCAN, DCN
3glycosaminoglycan metabolic processGO:0302039.8ACAN, VCAN, DCN
4chondroitin sulfate biosynthetic processGO:0302069.8VCAN, DCN
5cellular response to glucagon stimulusGO:0713779.3PRKAR1A, GNAS
6embryo implantationGO:0075669.0MMP2, MMP9
7proteolysisGO:0065088.9MMP9, MMP2, MMP1, ACAN
8collagen catabolic processGO:0305748.9COL14A1, MMP1, MMP2, MMP9
9blood coagulationGO:0075968.5GNAS, MMP1, PRKAR1A, CD36
10extracellular matrix disassemblyGO:0226178.4COL14A1, ACAN, MMP1, MMP2, MMP9, DCN
11small molecule metabolic processGO:0442818.2GNAS, DCN, VCAN, PRKAR1A, ACAN, CD36
12extracellular matrix organizationGO:0301988.1DCN, VCAN, MMP9, MMP2, MMP1, ACAN

Molecular functions related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronic acid bindingGO:0055409.9ACAN, VCAN
2glycosaminoglycan bindingGO:0055399.6VCAN, DCN
3collagen bindingGO:0055189.4COL14A1, MMP9, DCN
4metalloendopeptidase activityGO:0042229.0MMP9, MMP2, MMP1
5identical protein bindingGO:0428028.5VIM, MMP9, S100B, BAK1
6protein bindingGO:0055156.2GNAS, SERPINA3, VCAN, VIM, MMP9, MMP2

Products for genes affiliated with Odontogenic Myxoma

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3CDC
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