MCID: ODN005
MIFTS: 45

Odontogenic Myxoma malady

Rare diseases category

Summaries for Odontogenic Myxoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 The odontogenic myxoma is an uncommon benign odontogenic tumor arising from embryonic connective tissue... more...

MalaCards: Odontogenic Myxoma is related to periodontitis and granular cell tumor. An important gene associated with Odontogenic Myxoma is ACAN (aggrecan), and among its related pathways are Articular Cartilage Extracellular Matrix and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds keratan sulfate and dermatan sulfate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Odontogenic Myxoma

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

odontogenic myxoma 44 63


Related Diseases for Odontogenic Myxoma

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18GeneCards, 19GeneDecks
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Diseases related to Odontogenic Myxoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis30.6MMP9
2granular cell tumor30.4S100B, VIM
3basal cell carcinoma30.3BAK1, MMP1, DCN
4fibroma10.3
5gingivitis10.3
6nevoid basal cell carcinoma syndrome10.2
7tuberous sclerosis10.2
8pericoronitis10.2
9multiple epiphyseal dysplasia10.1ACAN
10syringoma10.1S100B
11osteochondritis dissecans10.1ACAN
12rosai-dorfman disease10.1S100B
13fibromatosis10.1VIM
14adenomatoid tumor10.1VIM
15glomus tumor10.1VIM
16synovitis10.1ACAN, MMP1
17creutzfeldt-jakob disease10.1SERPINA3, S100B
18meningioma10.1VIM, S100B
19spindle cell sarcoma10.1VIM, S100B
20marfan syndrome10.1CD36, DCN
21myoepithelioma10.1S100B, VIM
22dermatofibrosarcoma protuberans10.1S100B, VIM
23perineurioma10.1S100B, VIM
24sex cord-gonadal stromal tumor10.1S100B, VIM
25epidermolysis bullosa dystrophica10.1CD36, MMP1
26hemangiopericytoma10.1S100B, VIM
27progressive osseous heteroplasia10.1GNAS, DCN
28hypertensive heart disease10.1CD36, MMP1
29malignant mixed mullerian tumor10.1S100B, VIM
30chordoma10.1S100B, VIM
31arthropathy10.1ACAN, DCN, MMP1
32smooth muscle tumor10.1VIM, S100B
33angiosarcoma10.1SERPINA3, VIM
34malignant peripheral nerve sheath tumor10.1S100B, VIM
35mccune albright syndrome10.1GNAS, PRKAR1A
36acrodysostosis10.1PRKAR1A, GNAS
37osteofibrous dysplasia10.1GNAS, CD36
38skeletal dysplasias10.1ACAN, GNAS
39pseudoachondroplasia10.1DCN, ACAN, CD36
40ehlers-danlos syndrome10.1DCN, CD36
41carney complex10.1GNAS, PRKAR1A
42short stature10.1GNAS, CD36
43thoracic aortic aneurysm10.1MMP1, MMP2
44liver cirrhosis10.1SERPINA3, DCN, COL14A1
45secondary hyperparathyroidism of renal origin10.1CD36, PRKAR1A
46primary hyperparathyroidism10.1CD36, PRKAR1A
47fibrous histiocytoma10.1SERPINA3, VIM, S100B
48malignant fibroxanthoma10.1S100B, SERPINA3, VIM
49adrenal adenoma10.1PRKAR1A, GNAS
50adenoid cystic carcinoma10.1S100B, VIM, SERPINA3

Graphical network of the top 20 diseases related to Odontogenic Myxoma:



Diseases related to odontogenic myxoma

Symptoms for Odontogenic Myxoma

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Drugs & Therapeutics for Odontogenic Myxoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Odontogenic Myxoma

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Anatomical Context for Odontogenic Myxoma

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34MalaCards
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MalaCards organs/tissues related to Odontogenic Myxoma:

34
Bone

Animal Models for Odontogenic Myxoma or affiliated genes

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38MGI
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Publications for Odontogenic Myxoma

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53PubMed
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Articles related to Odontogenic Myxoma:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Infant Odontogenic Myxoma: A specific entity. (24429059)
2014
2
Surgical treatment of odontogenic myxoma and facial deformity in the same procedure. (24124313)
2013
3
An ectopic tooth concealing an odontogenic myxoma. (23505856)
2013
4
Synchronous occurrence of odontogenic myxoma with multiple keratocystic odontogenic tumors in nevoid basal cell carcinoma syndrome. (24163866)
2013
5
The imaging characteristics of odontogenic myxoma and a comparison of three different imaging modalities. (23972779)
2013
6
Using the condylar prosthesis after resection of a large odontogenic myxoma tumor in the mandible. (22976683)
2012
7
Dental pulp stem cells express proteins involved in the local invasiveness of odontogenic myxoma. (22473349)
2012
8
Conservative treatment of odontogenic myxoma. (21959474)
2011
9
Hypomethylation of tumor suppressor genes in odontogenic myxoma. (22011900)
2011
10
A clinico-pathologic correlation. Odontogenic myxoma. (20806706)
2010
11
An expanded odontogenic myxoma in maxilla. (21266837)
2010
12
Odontogenic myxoma--a case series and review of the surgical management. (19027311)
2009
13
Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro. (18587209)
2008
14
Odontogenic myxoma of maxilla. (18245926)
2008
15
Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. (17996487)
2008
16
Pediatric maxillary odontogenic myxoma: a report of 2 cases and review of management. (18423302)
2008
17
Maxillary odontogenic myxoma involving the maxillary sinus: case report. (18661026)
2008
18
Odontogenic myxoma of the maxilla: a case report. (18187991)
2007
19
Odontogenic myxoma of the maxilla. (17915662)
2007
20
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas. (16001434)
2005
21
Application of a surgical navigation system for implant surgery in a deficient alveolar ridge postexcision of an odontogenic myxoma. (16003627)
2005
22
Computed tomography of odontogenic myxoma. (15037142)
2004
23
Oral pathology quiz # 42. Case 3. Odontogenic myxoma. (15160432)
2004
24
Cytologic features of odontogenic myxoma. (15471259)
2004
25
Oral and maxillofacial pathology case of the month. Odontogenic myxoma. (12889417)
2003
26
Oral pathology quiz # 39. Case 1. Odontogenic myxoma. (12861649)
2003
27
Computed tomography of odontogenic myxoma. (12917281)
2003
28
Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF). (11545240)
2001
29
Odontogenic myxoma of maxillary sinus: CT and MR-pathologic correlation. (11274831)
2001
30
Immunohistochemical and histochemical characterization of the mucosubstances of odontogenic myxoma: histogenesis and differential diagnosis. (10399179)
1999
31
Odontogenic myxoma of the mandible in a filly. (10353360)
1999
32
Odontogenic myxoma. (10587272)
1999
33
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene. (9891502)
1998
34
Odontogenic myxoma: case report with reconstructive considerations. (9775463)
1998
35
Management of odontogenic myxoma of the maxilla. (9419108)
1997
36
Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the tumour stroma. (7536506)
1994
37
Odontogenic myxoma of the mandible. Report of a case and review of the literature. (7942346)
1994
38
Maxillary odontogenic myxoma. A case report. (7808718)
1994
39
Odontogenic myxoma: report of two cases with reconstruction considerations. (8336234)
1993
40
Odontogenic myxoma: histochemical and ultrastructural study. (1432734)
1992
41
Re: Odontogenic myxoma. Report of a periodontally-located case. (1622487)
1992
42
Odontogenic myxoma: an orthodontic presentation. (1910983)
1991
43
Odontogenic myxoma: report of a case with peculiar features. (1985190)
1991
44
Proper treatment of odontogenic myxoma. (2709229)
1989
45
Odontogenic myxoma: report of a case. (3294359)
1988
46
Childhood odontogenic myxoma: report of two cases. (3859846)
1985
47
Odontogenic myxoma of the maxilla. (891433)
1977
48
Ultrastructural study of an odontogenic myxoma. (1066602)
1976
49
Odontogenic myxoma: some histochemical considerations. (4163678)
1965
50
Odontogenic myxoma--mandible. (5214714)
1965

Variations for Odontogenic Myxoma

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Expression for genes affiliated with Odontogenic Myxoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Odontogenic Myxoma

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Pathways for genes affiliated with Odontogenic Myxoma

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51PathCards, 55R&D Systems, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 13EMD Millipore
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Pathways related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ACAN, DCN
29.9MMP1, SERPINA3
39.7DCN, VCAN, ACAN
49.6MMP1, MMP2
59.5MMP1, MMP9
69.3MMP2, MMP9
79.3MMP9, MMP2
89.3MMP2, MMP9
99.3GNAS, PRKAR1A
109.1VCAN, MMP2, BAK1
119.0MMP2, MMP9, DCN
129.0MMP2, MMP9, VCAN
13
Show member pathways
Signaling Pathways in Glioblastoma39
9.0MMP9, MMP2, MMP1
14
Show member pathways
9.0MMP9, MMP2, MMP1
159.0VCAN, MMP9, MMP1, ACAN
168.9MMP9, MMP2, CD36
178.9VCAN, VIM, MMP9, ACAN
188.7MMP1, MMP2, MMP9, DCN
198.6PRKAR1A, MMP1, MMP2, MMP9
20
Show member pathways
8.6MMP9, MMP2, MMP1, PRKAR1A
21
Show member pathways
8.5GNAS, MMP1, PRKAR1A, CD36
22
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.5MMP2, MMP9, GNAS
23
Show member pathways
8.4VCAN, MMP9, MMP2, MMP1, ACAN
24
Show member pathways
8.4BAK1, PRKAR1A, MMP2, MMP9
25
Show member pathways
8.0GNAS, DCN, VCAN, PRKAR1A, ACAN, CD36
26
Show member pathways
7.9MMP9, MMP2, MMP1, PRKAR1A, COL14A1, CD36
27
Show member pathways
7.8COL14A1, ACAN, MMP1, MMP2, MMP9, VCAN

Compounds for genes affiliated with Odontogenic Myxoma

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46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB
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Compounds related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1keratan sulfate469.6VCAN, ACAN, DCN, CD36
2dermatan sulfate469.4DCN, CD36, VIM, VCAN
3cgs-27023a469.4MMP2, MMP1, MMP9
4prinomastat469.3MMP1, MMP2, MMP9
5ilomastat469.3MMP9, MMP1, MMP2
6hydroxyapatite469.3CD36, VIM, DCN, S100B
7latanoprost46 1210.3MMP1, MMP9, MMP2
8cilomilast469.3MMP9, MMP1, MMP2
9chondroitin sulfate46 2510.2DCN, VIM, ACAN, CD36, VCAN
10alginate469.1MMP2, VCAN, ACAN, DCN, CD36
11hematoxylin469.1S100B, VIM, MMP1, MMP9
12(4-aminophenyl)mercuric acetate469.0MMP9, MMP2, CD36, MMP1
13zoledronic acid469.0MMP1, CD36, MMP2, MMP9
14batimastat46 62 1210.9CD36, MMP9, MMP2, MMP1
153-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide468.9S100B, BAK1, MMP9, MMP2
16heparin46 30 25 1211.8SERPINA3, VCAN, CD36, S100B, DCN, VIM
17hydroxyproline46 25 1210.7DCN, MMP9, CD36, MMP1, MMP2
18glycosaminoglycan468.7VCAN, DCN, CD36, MMP9, MMP1, ACAN
19pioglitazone30 46 52 1211.7CD36, MMP1, MMP2, MMP9
20celecoxib46 62 30 52 25 1213.6MMP9, MMP1, BAK1, MMP2
21vitamin a46 25 1210.6MMP9, VIM, MMP2, MMP1, SERPINA3
22methotrexate52 46 1210.6SERPINA3, MMP9, MMP1, MMP2, VIM
23ag 1478468.5MMP2, BAK1, MMP9, DCN
24cytochalasin d46 629.5VIM, MMP9, MMP2, CD36, MMP1
25leucine468.5DCN, S100B, ACAN, VIM, SERPINA3, GNAS
26troglitazone46 30 62 1211.4BAK1, CD36, MMP1, MMP2, MMP9
27ascorbic acid46 259.4S100B, ACAN, MMP1, CD36, MMP2
28sb 20358046 629.3MMP2, MMP9, MMP1, ACAN, VIM, CD36
29matrigel468.2CD36, MMP2, MMP9, MMP1, VIM, DCN
30genistein46 30 62 3 25 1213.2VIM, MMP9, CD36, MMP1, DCN, MMP2
3112-o-tetradecanoylphorbol 13-acetate468.0MMP9, MMP2, BAK1, MMP1, VIM
32ribonucleic acid467.9MMP1, MMP2, DCN, GNAS, MMP9
33cycloheximide467.8VIM, CD36, BAK1, MMP1, MMP2, MMP9
34glucose467.8SERPINA3, GNAS, VCAN, PRKAR1A, S100B, BAK1
35creatinine467.8S100B, CD36, MMP1, MMP9, DCN, MMP2
36tgf beta1467.7MMP1, ACAN, CD36, MMP9, VIM, VCAN
37procollagen467.7VIM, ACAN, CD36, COL14A1, MMP1, MMP2
38progesterone46 30 62 25 1211.7SERPINA3, GNAS, VIM, MMP1, S100B, MMP2
39vegf467.7S100B, VIM, MMP9, MMP2, MMP1, CD36
40pge2467.6CD36, ACAN, MMP1, MMP2, MMP9, DCN
41hyaluronic acid46 258.4DCN, VCAN, VIM, MMP9, MMP2, MMP1
42glutamate467.3GNAS, DCN, VIM, MMP2, MMP9, PRKAR1A
43paraffin467.2CD36, BAK1, S100B, MMP1, MMP2, SERPINA3
44estrogen467.2CD36, BAK1, S100B, MMP1, MMP9, VIM
45dexamethasone46 52 30 1210.1SERPINA3, DCN, S100B, MMP9, MMP1, PRKAR1A
46alanine467.1DCN, GNAS, SERPINA3, S100B, VIM, MMP9
47retinoic acid46 258.0SERPINA3, DCN, CD36, BAK1, S100B, MMP1
48serine466.9MMP2, GNAS, DCN, VIM, MMP9, MMP1
49calcium46 52 25 129.6SERPINA3, MMP2, MMP1, PRKAR1A, GNAS, MMP9
50cysteine466.0MMP2, GNAS, DCN, SERPINA3, CD36, BAK1

GO Terms for genes affiliated with Odontogenic Myxoma

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17Gene Ontology
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Cellular components related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7ACAN, VCAN, DCN
2lysosomal lumenGO:0432029.4ACAN, VCAN, DCN
3extracellular matrixGO:0310129.3DCN, VCAN, ACAN, COL14A1
4proteinaceous extracellular matrixGO:0055788.2VCAN, MMP9, MMP2, MMP1, ACAN, COL14A1
5extracellular spaceGO:0056158.1DCN, VCAN, MMP9, MMP2, COL14A1, S100B
6extracellular regionGO:0055766.6S100B, GNAS, DCN, SERPINA3, VCAN, MMP9

Biological processes related to Odontogenic Myxoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dermatan sulfate biosynthetic processGO:03020810.0DCN, VCAN
2chondroitin sulfate catabolic processGO:03020710.0VCAN, DCN
3glycosaminoglycan metabolic processGO:0302039.8ACAN, VCAN, DCN
4chondroitin sulfate biosynthetic processGO:0302069.8VCAN, DCN
5cellular response to glucagon stimulusGO:0713779.3PRKAR1A, GNAS
6embryo implantationGO:0075669.0MMP2, MMP9
7proteolysisGO:0065088.9MMP9, MMP2, MMP1, ACAN
8collagen catabolic processGO:0305748.9COL14A1, MMP1, MMP2, MMP9
9blood coagulationGO:0075968.5GNAS, MMP1, PRKAR1A, CD36
10extracellular matrix disassemblyGO:0226178.4COL14A1, ACAN, MMP1, MMP2, MMP9, DCN
11small molecule metabolic processGO:0442818.2GNAS, DCN, VCAN, PRKAR1A, ACAN, CD36
12extracellular matrix organizationGO:0301988.1DCN, VCAN, MMP9, MMP2, MMP1, ACAN

Molecular functions related to Odontogenic Myxoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronic acid bindingGO:0055409.9ACAN, VCAN
2glycosaminoglycan bindingGO:0055399.6VCAN, DCN
3collagen bindingGO:0055189.4COL14A1, MMP9, DCN
4metalloendopeptidase activityGO:0042229.0MMP9, MMP2, MMP1
5identical protein bindingGO:0428028.5VIM, MMP9, S100B, BAK1
6protein bindingGO:0055156.2GNAS, SERPINA3, VCAN, VIM, MMP9, MMP2

Products for genes affiliated with Odontogenic Myxoma

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Sources for Odontogenic Myxoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet