Odontoma malady

Wikipedia: The odontoma is a hamartoma of odontogenic origin.⁴⁴ more...

MalaCards: Odontoma is related to adenoameloblastoma and gingival overgrowth. An important gene associated with Odontoma is LHX8 (LIM homeobox 8), and among its related pathways are Signal transduction_PTEN pathway and Signal transduction PTEN pathway. The compounds silver and glycerol have been mentioned in the context of this disorder. Related mouse phenotype craniofacial.

odontoma 30 32 43

Diseases related to odontoma by text searches and GeneDecks gene sharing:

(show all 13)

id	Related Disease	Score	Top Affiliating Genes
1	adenoameloblastoma	12.5	DSPP, PCNA
2	gingival overgrowth	12.5	PCNA, DSPP
3	lung occult squamous cell carcinoma	12.4	PCNA, DSPP
4	breast adenocarcinoma	12.3	PCNA, DSPP
5	stickler syndrome	12.3	LHX8, DSPP
6	craniopharyngioma	12.2	PCNA, LEF1
7	anaplastic large cell lymphoma	12.0	PCNA, LEF1
8	cleft palate	12.0	PCNA, LHX8, DSPP
9	familial adenomatous polyposis	11.8	PCNA, LEF1
10	odontoma dysphagia syndrome	7.8
11	sinusitis	6.6
12	ataxia telangiectasia	5.7
13	calcifying epithelial odontogenic tumor	5.7

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to odontoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	8.5	LHX8, LEF1, DSPP

Articles related to odontoma:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Comparative study of LHX8 expression between odontoma and dental tissue-derived stem cells. (21143530)	Kim J.Y.... Choung P.H.	2011	LHX8
2	Complex odontoma. (20478785)	Preetha A.... Ganapathy K.S.	2010	DSPP
3	Differentiation and regenerative capacities of human odontoma-derived mesenchymal cells. (19281762)	Song J.S.... Akintoye S.O.	2009	DSPP
4	A large ameloblastic fibro-odontoma of the right mandible. (17195825)	Oghli A.A.... Hofele C.	2007	DSPP
5	Presence of ghost cells and the Wnt signaling pathway in odontomas. (17617832)	Tanaka A.... Kusama K.	2007	LEF1
6	Unusually large complex odontoma in maxillary sinus a ssociated with unerupted tooth. Report of case and review of literature. (17891883)	Singer S.R.... Quaranta P.	2007	DSPP
7	Odontomas in pediatric dentistry: report of two cases. (16491972)	Delbem A.C.... GonAsalves T.C.	2005	DSPP
8	Large complex odontoma of the left maxillary sinus. (16416361)	Cabov T.... ManojloviA8 S.	2005	DSPP
9	Odontoma: a clinicopathologic study of 81 cases. (14976568)	Chang J.Y.... Chiang C.P.	2003	DSPP
10	Actinomyces infection in a compound odontoma (9923122)	Di Tommaso L.... Eusebi V.	1998	DSPP
11	Microradiographic and microscopic investigation of a rare case of complex odontoma. (9690259)	Kaneko M.... Hosokawa Y.	1998	DSPP
12	Ameloblastic fibro-odontoma of the maxilla: case repo rt. (9484121)	Ozer E.... Aktas S.	1997	DSPP
13	Cell kinetics in mandibular ameloblastic fibro-odontoma evaluated by bromodeoxyuridine and proliferating cell nuclear antigen immunohistochemistry: case report. (8909741)	Sekine J.... Okabe H.	1996	PCNA
14	Morphodifferentiation and histodifferentiation of the dental hard tissues in compound odontoma: a study of undemineralized material. (1403841)	Piattelli A.... Trisi P.	1992	DSPP
15	The ameloblastic fibro-odontoma (1811980)	GrAotz K.W.... Sailer H.F.	1991	DSPP

Genes related to odontoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LHX8	LIM homeobox 8	11.1	Publications, Summaries
2	DSPP	dentin sialophosphoprotein	11.0	Publications
3	LEF1	lymphoid enhancer-binding factor 1	11.0	Publications
4	PCNA	proliferating cell nuclear antigen	11.0	Publications

Pathways related to odontoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	9.1	PCNA, LEF1
2	Signal transduction PTEN pathway10	8.8	PCNA, LEF1

Compounds related to odontoma according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	silver32	9.4	PCNA, DSPP
2	glycerol32 9 18 9	12.3	PCNA, DSPP
3	formaldehyde32 18	10.2	PCNA, DSPP
4	carbon32	9.0	PCNA, DSPP
5	alanine32	8.5	PCNA, DSPP, LEF1

Biological processes related to odontoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	odontogenesis of dentin-containing tooth	GO:042475	9.1	LHX8, LEF1