MCID: OSC001
MIFTS: 26

Oeis Complex malady

Categories: Genetic diseases, Nephrological diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Oeis Complex

Aliases & Descriptions for Oeis Complex:

Name: Oeis Complex 54 24 56
Omphalocele-Cloacal Exstrophy-Imperforate Anus-Spinal Defect Syndrome 56
Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects 24
Omphalocele Exstrophy Imperforate Anus 69
Cloacal Exstrophy 56

Characteristics:

Orphanet epidemiological data:

56
cloacal exstrophy
Inheritance: Multigenic/multifactorial; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

HPO:

32
oeis complex:
Inheritance sporadic


Classifications:



External Ids:

OMIM 54 258040
Orphanet 56 ORPHA93929
ICD10 via Orphanet 34 Q64.1

Summaries for Oeis Complex

MalaCards based summary : Oeis Complex, also known as omphalocele-cloacal exstrophy-imperforate anus-spinal defect syndrome, is related to omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects complex and exstrophy of bladder bladder exstrophy and epispadias complex, included, and has symptoms including anal atresia, talipes equinovarus and intestinal malrotation. An important gene associated with Oeis Complex is MNX1 (Motor Neuron And Pancreas Homeobox 1). Affiliated tissues include kidney, colon and uterus.

Description from OMIM: 258040

Related Diseases for Oeis Complex

Diseases related to Oeis Complex via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects complex 11.6
2 exstrophy of bladder bladder exstrophy and epispadias complex, included 11.5
3 omphalocele 10.3
4 imperforate anus 10.3
5 cloacal exstrophy 9.9
6 transposition of the great arteries 9.7
7 nail-patella syndrome 9.7
8 lipoma 9.7
9 bladder exstrophy 9.7
10 lumbosacral lipoma 9.7
11 limb-body wall complex 9.7
12 pentalogy of cantrell 9.7

Graphical network of the top 20 diseases related to Oeis Complex:



Diseases related to Oeis Complex

Symptoms & Phenotypes for Oeis Complex

Symptoms by clinical synopsis from OMIM:

258040

Clinical features from OMIM:

258040

Human phenotypes related to Oeis Complex:

56 32 (show all 47)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anal atresia 56 32 Frequent (79-30%) HP:0002023
2 talipes equinovarus 56 32 Frequent (79-30%) HP:0001762
3 intestinal malrotation 56 32 Frequent (79-30%) HP:0002566
4 hemivertebrae 56 32 Frequent (79-30%) HP:0002937
5 hydroureter 56 32 Occasional (29-5%) HP:0000072
6 omphalocele 56 32 Very frequent (99-80%) HP:0001539
7 myelomeningocele 56 32 Frequent (79-30%) HP:0002475
8 bladder exstrophy 56 32 Very frequent (99-80%) HP:0002836
9 cloacal exstrophy 56 32 Very frequent (99-80%) HP:0010475
10 hydrocephalus 32 HP:0000238
11 ectopic kidney 56 Occasional (29-5%)
12 cryptorchidism 32 HP:0000028
13 horseshoe kidney 56 Occasional (29-5%)
14 hip dislocation 56 Frequent (79-30%)
15 arnold-chiari malformation 32 HP:0002308
16 renal hypoplasia/aplasia 56 Occasional (29-5%)
17 vesicoureteral reflux 56 Very frequent (99-80%)
18 spina bifida 56 Frequent (79-30%)
19 hypoplasia of penis 56 Very frequent (99-80%)
20 pelvic kidney 32 HP:0000125
21 rectovaginal fistula 32 HP:0000143
22 anteriorly placed anus 32 HP:0001545
23 ureteropelvic junction obstruction 56 Occasional (29-5%)
24 hydronephrosis 32 HP:0000126
25 epispadias 32 HP:0000039
26 ambiguous genitalia, male 32 HP:0000033
27 micropenis 32 HP:0000054
28 abnormality of the tibia 56 Frequent (79-30%)
29 renal agenesis 32 HP:0000104
30 congenital hip dislocation 32 HP:0001374
31 11 pairs of ribs 32 HP:0000878
32 ureterocele 56 Occasional (29-5%)
33 duplicated collecting system 32 HP:0000081
34 abnormality of the fibula 56 Frequent (79-30%)
35 labial hypoplasia 32 HP:0000066
36 intestinal duplication 56 Frequent (79-30%)
37 ambiguous genitalia, female 32 HP:0000061
38 abnormality of the clitoris 56 Very frequent (99-80%)
39 duplicated colon 32 HP:0005223
40 abnormality of the fallopian tube 56 Occasional (29-5%)
41 absence of the sacrum 32 HP:0010305
42 absent foot 56 Frequent (79-30%)
43 bifid uterus 32 HP:0000136
44 tethered cord 32 HP:0002144
45 vesicovaginal fistula 32 HP:0001586
46 sacral segmentation defect 32 HP:0008490
47 absent scrotum 32 HP:0008707

Drugs & Therapeutics for Oeis Complex

Interventional clinical trials:


id Name Status NCT ID Phase
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084

Search NIH Clinical Center for Oeis Complex

Genetic Tests for Oeis Complex

Genetic tests related to Oeis Complex:

id Genetic test Affiliating Genes
1 Oeis Complex 24

Anatomical Context for Oeis Complex

MalaCards organs/tissues related to Oeis Complex:

39
Kidney, Colon, Uterus

Publications for Oeis Complex

Articles related to Oeis Complex:

(show all 29)
id Title Authors Year
1
Penile duplication as genital abnormality in OEIS complex: a fetal autopsy case report. ( 26513516 )
2016
2
Multimodality Renal Failure in a Patient with OEIS Complex. ( 26495176 )
2015
3
Fetal and neonatal presentation of OEIS complex. ( 26520699 )
2015
4
Early prenatal diagnosis of the OEIS complex with different appearance in early compared with late pregnancy before spontaneous rupture of the cloacal membrane. ( 24623061 )
2014
5
Omphalocele, exstrophy of cloaca, imperforate anus and spinal defect (OEIS Complex) with overlapping features of body stalk anomaly (limb body wall complex). ( 25400352 )
2014
6
Re: Urological outcomes in the omphalocele exstrophy imperforate anus spinal defects (OEIS) complex: experience with 80 patients. ( 24703152 )
2014
7
OEIS complex. ( 24839537 )
2013
8
Urological outcomes in the omphalocele exstrophy imperforate anus spinal defects (OEIS) complex: experience with 80 patients. ( 22640865 )
2013
9
Prenatal findings of omphalocele-exstrophy of the bladder-imperforate anus-spinal defects (OEIS) complex. ( 22925220 )
2012
10
Gastrointestinal reconstruction and outcomes for patients with the OEIS complex. ( 21453858 )
2011
11
Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication. ( 21204209 )
2011
12
Prenatal diagnosis of OEIS (omphalocele, bladder exstrophy, imperforate anus, clubfeet) variant associated with increased nuchal translucency and OEIS complex with ambiguous genitalia associated with corrected transposition of the great arteries: case series and review of the literature. ( 21475965 )
2011
13
Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex in a child with nail-patella syndrome. ( 20880310 )
2010
14
OEIS complex associated with chromosome 1p36 deletion: a case report and review. ( 20101692 )
2010
15
Double lumbosacral lipomas of the dorsal and filar types associated with OEIS complex: case report. ( 19855150 )
2009
16
Discordant omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex and cardiac malformations in monochorionic twins. ( 19842883 )
2009
17
Supernumerary kidney in a child with OEIS complex. ( 19371928 )
2009
18
Neurosurgical management of occult spinal dysraphism associated with OEIS complex. ( 17962955 )
2008
19
OEIS complex with major cardiac malformation: a case report. ( 17883075 )
2007
20
Prenatal ascertainment of OEIS complex/cloacal exstrophy - 15 new cases and literature review. ( 17702047 )
2007
21
Syndromes and disorders associated with omphalocele (II): OEIS complex and Pentalogy of Cantrell. ( 17638617 )
2007
22
Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex associated with increased nuchal translucency. ( 12858313 )
2003
23
OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects): a review of 14 cases. ( 11251992 )
2001
24
OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects) in monozygotic twins. ( 10213043 )
1999
25
Perinatal features of omphalocele-exstrophy-imperforate anus-spinal defects (OEIS complex) associated with large meningomyeloceles and severe limb defects. ( 9259943 )
1997
26
Omphalocele-exstrophy-imperforate-anus-spina bifida (OEIS) complex in a male prenatally exposed to diazepam. ( 7711456 )
1995
27
The OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects): recurrence in sibs. ( 1433234 )
1992
28
OEIS complex (cloacal exstrophy): prenatal diagnosis in the second trimester. ( 2456564 )
1988
29
The OEIS complex (omphalocele, exstrophy, imperforate anus, spinal defects). ( 728566 )
1978

Variations for Oeis Complex

Expression for Oeis Complex

Search GEO for disease gene expression data for Oeis Complex.

Pathways for Oeis Complex

GO Terms for Oeis Complex

Sources for Oeis Complex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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