MCID: OLF005
MIFTS: 41

Olfactory Neuroblastoma malady

Rare diseases, Neuronal diseases, Cancer diseases, Smell/Taste diseases categories

Summaries for Olfactory Neuroblastoma

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 EsthesioneuroblastomaĀ is a rare cancer of the upper part of the nasal cavity called the cribiform plate, which is a bone deep in the skull between the eyes, and above the ethmoid sinuses. it develops in nerve tissue associated with the sense of smell and can occur in people of any age. this cancer is very uncommon, accounting for 7 percent of all cancers of the nasal cavity and paranasal sinuses. although it generally grows slowly, an esthesioneuroblastoma can sometimes grow very quickly. fast-growing tumors can metastasize (spread) even many years after treatment of the initial tumor. last updated: 1/13/2009

MalaCards: Olfactory Neuroblastoma, also known as esthesioneuroblastoma, is related to meningioma and sarcoma. An important gene associated with Olfactory Neuroblastoma is EPOR (erythropoietin receptor). The compounds phosphotyrosine and acth have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lymph node.

Aliases & Classifications for Olfactory Neuroblastoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 60SNOMED-CT via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
olfactory neuroblastoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

olfactory neuroblastoma 9 44 11 50 63
esthesioneuroblastoma 9 44 46 50
paranasal sinus olfactory neuroblastoma 9
olfactory esthesioneuroblastoma 9
esthesioneuroepithelioma 9
asthesioneuroblastoma 9


External Ids:

Disease Ontology9 DOID:369
NCIt41 C3789, C6016
MeSH36 D018304
SNOMED-CT via Orphanet60 76060004, 422886007

Related Diseases for Olfactory Neuroblastoma

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18GeneCards, 19GeneDecks
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Diseases related to Olfactory Neuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.4S100B, SSTR2
2sarcoma30.3SSTR2, S100B, GLI1
3peripheral primitive neuroectodermal tumor30.2S100B, EPOR
4neuroendocrine carcinoma30.2S100B, SYNM
5melanoma30.1GLI1, S100B, SSTR2, EPOR
6adenocarcinoma30.0EPOR, SSTR2, SYNM, GLI1
7neuroblastoma11.3
8nasal cavity olfactory neuroblastoma10.4
9cushing's syndrome10.4
10craniopharyngioma10.3
11primitive neuroectodermal tumor10.3
12sinonasal undifferentiated carcinoma10.3
13syndrome of inappropriate antidiuretic hormone10.3
14postpartum depression10.1
15acute leukemia10.1
16choroiditis10.1
17ganglioneuroma10.1
18adenoma10.1
19hypertension10.1
20leukemia10.1
21meningitis10.1
22pituitary adenoma10.1
23neuroepithelioma10.1
24radiation induced meningioma10.1
25pineocytoma10.1S100B
26neurofibroma10.1S100B
27hemangioblastoma10.0S100B, EPOR
28paraganglioma10.0S100B, SSTR2
29pancreatic cancer10.0SSTR2, GLI1
30rhabdomyosarcoma10.0GLI1, S100B
31carcinoid syndrome10.0GLI1, SSTR2
32pheochromocytoma10.0SSTR2, EPOR
33olfactory groove meningioma10.0
34hypercalcemia10.0
35extramedullary plasmacytoma10.0
36inverted papilloma10.0
37ophthalmoplegia10.0
38papilloma10.0
39plasmacytoma10.0
40soft tissue sarcoma10.0
41gastric adenocarcinoma10.0EPOR, SSTR2, GLI1
42stomach cancer10.0GLI1, SSTR2, EPOR
43malignant glioma9.9GLI1, S100B, SSTR2, EPOR
44prostate cancer9.9GLI1, SSTR2, EPOR
45medulloblastoma9.9GLI1, S100B, SYNM, SSTR2

Graphical network of the top 20 diseases related to Olfactory Neuroblastoma:



Diseases related to olfactory neuroblastoma

Symptoms for Olfactory Neuroblastoma

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Drugs & Therapeutics for Olfactory Neuroblastoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Genetic Tests for Olfactory Neuroblastoma

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Anatomical Context for Olfactory Neuroblastoma

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34MalaCards
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MalaCards organs/tissues related to Olfactory Neuroblastoma:

34
Eye, Bone, Lymph node, Breast, Pituitary

Animal Models for Olfactory Neuroblastoma or affiliated genes

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Publications for Olfactory Neuroblastoma

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53PubMed
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Articles related to Olfactory Neuroblastoma:

(show top 50)    (show all 226)
idTitleAuthorsYear
1
Olfactory neuroblastoma: a 35-year experience and suggested follow-up protocol. (24347437)
2013
2
Aggressive olfactory neuroblastoma invading the oral cavity: report of a rare case and review of the literature. (22374068)
2012
3
Gamma KnifeAr radiosurgery for recurrent intracranial olfactory neuroblastoma (esthesioneuroblastoma): a case report. (22889266)
2012
4
Subcutaneous metastasis of olfactory neuroblastoma - an uncommon presentation. (23765147)
2011
5
Olfactory neuroblastoma in children: results of multimodality treatment in 2 patients. (21247350)
2011
6
Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma. (20811561)
2010
7
Expression of SSTR2 and P-STAT3 in human olfactory neuroblastoma]. (20942237)
2010
8
Olfactory neuroblastoma. (20596981)
2009
9
Large olfactory neuroblastoma (esthesioneuroblastoma) surgically treated with an Altemir technique modification: a case report. (19506925)
2009
10
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
11
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
12
Pigmented olfactory neuroblastoma: a CD56-positive mimic of melanoma. (18283196)
2008
13
Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma. (18431543)
2008
14
Pleomorphic olfactory neuroblastoma (esthesioneuroblastoma): histopathological findings and clinical course. (17727493)
2007
15
Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience. (17427966)
2007
16
Esthesioneuroblastoma (olfactory neuroblastoma) with hemorrhage: an unusual presentation. (17268590)
2006
17
Retropharyngeal lymph node metastasis from olfactory neuroblastoma: A report of two cases. (16691416)
2006
18
Radiology quiz case 3. Olfactory neuroblastoma, or esthesioneuroblastoma (ENB). (16230602)
2005
19
Co-expression of TrkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells]. (12934398)
2003
20
Co-expression of trkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells. (12175342)
2002
21
Olfactory neuroblastoma visualized by Technetium-99m-ECD SPECT. (11724258)
2001
22
Olfactory neuroblastoma as a second malignant neoplasm in a patient previously treated for childhood acute leukemia. (11594709)
2001
23
Choroidal metastasis from olfactory neuroblastoma (esthesioneuroblastoma). (10546948)
1999
24
Olfactory neuroblastoma (esthesioneuroblastoma) and esthesioneuroepithelioma: histologic and immunohistochemical study. (9757618)
1998
25
Imaging of olfactory neuroblastoma--an analysis of 17 cases. (9673731)
1998
26
Olfactory neuroblastoma as acute postpartum depression. (9796773)
1998
27
Imaging of olfactory neuroblastoma by In-111 bleomycin complex. (8697683)
1996
28
Expression of the human Achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma). (8583243)
1995
29
Olfactory neuroblastoma. (1497735)
1992
30
Olfactory neuroblastoma associated with Kallman's syndrome. (1564744)
1992
31
Olfactory neuroblastoma: clinicopathologic and immunohistochemical characterization of four representative cases. (2215035)
1990
32
Activation of retrovirus in transgenic mice: association with development of olfactory neuroblastoma. (2164606)
1990
33
Olfactory neuroblastoma: report of a case and review of the literature. (2651629)
1989
34
Olfactory neuroblastoma. (2720589)
1989
35
Olfactory neuroblastoma. Cytodiagnostic features in a case with ultrastructural and immunohistochemical correlation. (2453984)
1988
36
Recurrent olfactory neuroblastoma treated by radiation, surgery, and chemotherapy: &quot;a case report&quot;. (3807372)
1987
37
Olfactory neuroblastoma metastatic to the eye. (3653724)
1987
38
Chronic syndrome of inappropriate antidiuretic hormone secretion and hypertension in a patient with olfactory neuroblastoma. Evidence of ectopic production of arginine vasopressin by the tumor. (3753113)
1986
39
Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. (2430477)
1986
40
Histogenesis of olfactory neuroblastoma. I. Electron microscopy of typical human case. (4080636)
1985
41
Olfactory neuroblastoma: presentation of a case and review of the Japanese literature. (6694503)
1984
42
Surgical pathology of olfactory neuroblastoma. (6490385)
1984
43
Olfactory neuroblastoma. Chemotherapy and radiotherapy for extensive disease. (6541469)
1984
44
Pigmented olfactory neuroblastoma: a new example of melanotic neuroepithelial neoplasm. (7074529)
1982
45
Olfactory neuroblastoma: long-term survival. (429906)
1979
46
Olfactory neuroblastoma. A clinical analysis of 17 cases. (1260676)
1976
47
Olfactory neuroblastoma. (1202918)
1975
48
Olfactory neuroblastoma. Management and prognosis. (804302)
1975
49
Olfactory neuroblastoma. (5572831)
1971
50
Psammoma bodies in olfactory neuroblastoma. (5842397)
1965

Variations for Olfactory Neuroblastoma

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Expression for genes affiliated with Olfactory Neuroblastoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Olfactory Neuroblastoma

Search GEO for disease gene expression data for Olfactory Neuroblastoma.

Pathways for genes affiliated with Olfactory Neuroblastoma

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Compounds for genes affiliated with Olfactory Neuroblastoma

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46Novoseek, 25HMDB
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Compounds related to Olfactory Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphotyrosine469.4SSTR2, EPOR
2acth469.0S100B, SSTR2
3paraffin469.0EPOR, SSTR2, S100B
4thymidine46 259.9S100B, SSTR2, EPOR
5vegf468.9EPOR, SSTR2, S100B
6estrogen468.8S100B, SSTR2, EPOR
7glucose468.5GLI1, S100B, SSTR2, EPOR

GO Terms for genes affiliated with Olfactory Neuroblastoma

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17Gene Ontology
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Molecular functions related to Olfactory Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5GLI1, S100B, SYNM, SSTR2, EPOR

Products for genes affiliated with Olfactory Neuroblastoma

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Sources for Olfactory Neuroblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet