MCID: OLF005
MIFTS: 42

Olfactory Neuroblastoma malady

Rare diseases, Neuronal diseases, Cancer diseases, Smell/Taste diseases categories
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Summaries for Olfactory Neuroblastoma

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NIH Rare Diseases:42 Esthesioneuroblastoma is a rare cancer of the upper part of the nasal cavity called the cribiform plate, which is a bone deep in the skull between the eyes, and above the ethmoid sinuses. it develops in nerve tissue associated with the sense of smell and can occur in people of any age. this cancer is very uncommon, accounting for 7 percent of all cancers of the nasal cavity and paranasal sinuses. although it generally grows slowly, an esthesioneuroblastoma can sometimes grow very quickly. fast-growing tumors can metastasize (spread) even many years after treatment of the initial tumor. last updated: 1/13/2009

MalaCards based summary: Olfactory Neuroblastoma, also known as esthesioneuroblastoma, is related to peripheral primitive neuroectodermal tumor and meningioma. An important gene associated with Olfactory Neuroblastoma is EPOR (erythropoietin receptor). The compounds phosphotyrosine and acth have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lymph node.

Aliases & Classifications for Olfactory Neuroblastoma

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Olfactory Neuroblastoma, Aliases & Descriptions:

Name: Olfactory Neuroblastoma 8 42 10 48 62
Esthesioneuroblastoma 8 42 44 48
Paranasal Sinus Olfactory Neuroblastoma 8 62
Esthesioneuroblastoma, Olfactory 62
 
Olfactory Esthesioneuroblastoma 8
Aesthesioneuroepithelioma 62
Esthesioneuroepithelioma 8
Asthesioneuroblastoma 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
olfactory neuroblastoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:369
MeSH34 D018304
NCIt39 C3789, C6016

Related Diseases for Olfactory Neuroblastoma

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Graphical network of the top 20 diseases related to Olfactory Neuroblastoma:



Diseases related to olfactory neuroblastoma

Symptoms for Olfactory Neuroblastoma

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Drugs & Therapeutics for Olfactory Neuroblastoma

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Drug clinical trials:

Search ClinicalTrials for Olfactory Neuroblastoma

Search NIH Clinical Center for Olfactory Neuroblastoma

Genetic Tests for Olfactory Neuroblastoma

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Anatomical Context for Olfactory Neuroblastoma

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MalaCards organs/tissues related to Olfactory Neuroblastoma:

32
Eye, Bone, Lymph node, Breast, Pituitary

Animal Models for Olfactory Neuroblastoma or affiliated genes

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Publications for Olfactory Neuroblastoma

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Articles related to Olfactory Neuroblastoma:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Olfactory neuroblastoma with focal ganglioneuroblastic differentiation: a case report with literature review. (25291869)
2014
2
Case report: recurrent olfactory neuroblastoma nasal cavity in young boy refractory to chemotherapy with remission after radiotherapy and sparing of left eye. (25316398)
2014
3
Syndrome of inappropriate antidiuretic hormone secretion associated with olfactory neuroblastoma. (24220439)
2013
4
Olfactory neuroblastoma: a 35-year experience and suggested follow-up protocol. (24347437)
2013
5
Aggressive olfactory neuroblastoma invading the oral cavity: report of a rare case and review of the literature. (22374068)
2012
6
Gamma KnifeAr radiosurgery for recurrent intracranial olfactory neuroblastoma (esthesioneuroblastoma): a case report. (22889266)
2012
7
Subcutaneous metastasis of olfactory neuroblastoma - an uncommon presentation. (23765147)
2011
8
Olfactory neuroblastoma in children: results of multimodality treatment in 2 patients. (21247350)
2011
9
Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma. (20811561)
2010
10
Expression of SSTR2 and P-STAT3 in human olfactory neuroblastoma]. (20942237)
2010
11
Olfactory neuroblastoma. (20596981)
2009
12
Large olfactory neuroblastoma (esthesioneuroblastoma) surgically treated with an Altemir technique modification: a case report. (19506925)
2009
13
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
14
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
15
Pigmented olfactory neuroblastoma: a CD56-positive mimic of melanoma. (18283196)
2008
16
Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma. (18431543)
2008
17
Pleomorphic olfactory neuroblastoma (esthesioneuroblastoma): histopathological findings and clinical course. (17727493)
2007
18
Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience. (17427966)
2007
19
Esthesioneuroblastoma (olfactory neuroblastoma) with hemorrhage: an unusual presentation. (17268590)
2006
20
Radiology quiz case 3. Olfactory neuroblastoma, or esthesioneuroblastoma (ENB). (16230602)
2005
21
Co-expression of TrkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells]. (12934398)
2003
22
Co-expression of trkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells. (12175342)
2002
23
Olfactory neuroblastoma visualized by Technetium-99m-ECD SPECT. (11724258)
2001
24
Olfactory neuroblastoma as a second malignant neoplasm in a patient previously treated for childhood acute leukemia. (11594709)
2001
25
Choroidal metastasis from olfactory neuroblastoma (esthesioneuroblastoma). (10546948)
1999
26
Olfactory neuroblastoma (esthesioneuroblastoma) and esthesioneuroepithelioma: histologic and immunohistochemical study. (9757618)
1998
27
Imaging of olfactory neuroblastoma--an analysis of 17 cases. (9673731)
1998
28
Olfactory neuroblastoma as acute postpartum depression. (9796773)
1998
29
Imaging of olfactory neuroblastoma by In-111 bleomycin complex. (8697683)
1996
30
Expression of the human Achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma). (8583243)
1995
31
Olfactory neuroblastoma. (1497735)
1992
32
Olfactory neuroblastoma associated with Kallman's syndrome. (1564744)
1992
33
Olfactory neuroblastoma: clinicopathologic and immunohistochemical characterization of four representative cases. (2215035)
1990
34
Activation of retrovirus in transgenic mice: association with development of olfactory neuroblastoma. (2164606)
1990
35
Olfactory neuroblastoma: report of a case and review of the literature. (2651629)
1989
36
Olfactory neuroblastoma. (2720589)
1989
37
Olfactory neuroblastoma. Cytodiagnostic features in a case with ultrastructural and immunohistochemical correlation. (2453984)
1988
38
Recurrent olfactory neuroblastoma treated by radiation, surgery, and chemotherapy: &quot;a case report&quot;. (3807372)
1987
39
Olfactory neuroblastoma metastatic to the eye. (3653724)
1987
40
Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. (2430477)
1986
41
Histogenesis of olfactory neuroblastoma. I. Electron microscopy of typical human case. (4080636)
1985
42
Olfactory neuroblastoma: presentation of a case and review of the Japanese literature. (6694503)
1984
43
Surgical pathology of olfactory neuroblastoma. (6490385)
1984
44
Olfactory neuroblastoma. Chemotherapy and radiotherapy for extensive disease. (6541469)
1984
45
Pigmented olfactory neuroblastoma: a new example of melanotic neuroepithelial neoplasm. (7074529)
1982
46
Olfactory neuroblastoma: long-term survival. (429906)
1979
47
Olfactory neuroblastoma. (1202918)
1975
48
Olfactory neuroblastoma. Management and prognosis. (804302)
1975
49
Olfactory neuroblastoma. (5572831)
1971
50
Psammoma bodies in olfactory neuroblastoma. (5842397)
1965

Variations for Olfactory Neuroblastoma

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Expression for genes affiliated with Olfactory Neuroblastoma

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Expression patterns in normal tissues for genes affiliated with Olfactory Neuroblastoma

Search GEO for disease gene expression data for Olfactory Neuroblastoma.

Pathways for genes affiliated with Olfactory Neuroblastoma

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Compounds for genes affiliated with Olfactory Neuroblastoma

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Sources:
44Novoseek, 24HMDB
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Compounds related to Olfactory Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphotyrosine449.4SSTR2, EPOR
2acth449.0S100B, SSTR2
3paraffin449.0EPOR, SSTR2, S100B
4thymidine44 249.9S100B, SSTR2, EPOR
5vegf448.9EPOR, SSTR2, S100B
6estrogen448.8S100B, SSTR2, EPOR
7glucose448.5GLI1, S100B, SSTR2, EPOR

GO Terms for genes affiliated with Olfactory Neuroblastoma

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Molecular functions related to Olfactory Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5GLI1, S100B, SYNM, SSTR2, EPOR

Products for genes affiliated with Olfactory Neuroblastoma

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Sources for Olfactory Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet