MCID: OLG015
MIFTS: 40

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases categories

Summaries for Oligoarticular Juvenile Arthritis

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32MalaCards
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MalaCards: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including articular/joint pain/arthralgia, hydrarthrosis/articular/joint effusion and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Oligoarticular Juvenile Arthritis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Inflammatory Response Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

oligoarticular juvenile arthritis 48
juvenile pauciarticular chronic arthritis 60
pauciarticular chronic arthritis 48


External Ids:

ICD10 via Orphanet26 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3CSF2, IL2RB, PTPN22, TGFB1
2pauciarticular chronic arthritis10.4
3oligoarticular juvenile arthritis with anti-nuclear antibodies10.4
4oligoarticular juvenile arthritis without anti-nuclear antibodies10.4
5deficiency anemia10.0CSF2
6hemophagocytic lymphohistiocytosis10.0IL2RA
7tuberculosis10.0IL2RA
8acquired immunodeficiency syndrome10.0CSF2
9inflammatory bowel disease10.0TGFB1
10crohn's disease10.0PTPN2
11acute leukemia10.0CSF2
12pancreatitis10.0TGFB1
13uveitis10.0IL2RA
14dermatitis10.0CSF2
15thrombocytopenia10.0CSF2
16celiac disease10.0PTPN22
17nephrotic syndrome10.0IL2RA
18vitiligo10.0PTPN22
19thyroiditis10.0PTPN22
20pulmonary fibrosis10.0TGFB1
21liver cirrhosis10.0TGFB1
22glomerulonephritis10.0TGFB1
23influenza10.0IL2RB
24malaria10.0IL2RB
25eye disease10.0TGFB1
26hyperthyroidism10.0PTPN22
27neutropenia10.0CSF2
28osteoarthritis10.0TGFB1
29lupus nephritis10.0TGFB1, IL2RA
30viral hepatitis10.0FAS
31common variable immune deficiency10.0IL2RB, IL2RA
32sarcoidosis10.0IL2RA, IL2RB
33tetanus10.0CSF2, IL2RA
34obesity10.0PTPN2
35diabetes mellitus10.0TGFB1, PTPN22
36psoriasis10.0PTPN22, IL2RA
37posterior uveitis10.0IL2RB, IL2RA
38t-cell large granular lymphocyte leukemia10.0CSF2, IL2RB
39systemic lupus erythematosus10.0STAT4
40sjogren's syndrome10.0FAS, IL2RA
41mycosis fungoides10.0IL2RB, IL2RA
42tropical spastic paraparesis10.0IL2RB, IL2RA
43vogt-koyanagi-harada disease10.0IL2RA, FAS
44immunodeficiency, common variable, 710.0IL2RB, IL2RA
45extrinsic allergic alveolitis10.0IL2RB, IL2RA
46encephalomyelitis10.0STAT4
47hepatocellular carcinoma10.0FAS, TGFB1
48acute graft versus host disease10.0IL2RA, IL2RB
49adenocarcinoma10.0TGFB1, FAS
50myelodysplastic syndromes10.0FAS, CSF2

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Clinical Features for Oligoarticular Juvenile Arthritis

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48Orphanet
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Symptoms:

48
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Oligoarticular Juvenile Arthritis

Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Search CenterWatch for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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32MalaCards
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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

32
Eye, Bone

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oligoarticular Juvenile Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1PTPN22
2MP:00053787.0TGFB1, CSF2, FAS, IL2RA, IL2RB, PTPN22
3MP:00053767.0FAS, STAT4, TYK2, PTPN22, PTPN2, TGFB1
4MP:00053976.1TGFB1, CSF2, FAS, STAT4, TYK2, CD247
5MP:00053876.1CSF2, FAS, STAT4, TYK2, CD247, IL2RA
6MP:00053846.0TYK2, STAT4, FAS, CSF2, CD247, IL2RA
7MP:00107686.0FAS, STAT4, TYK2, CD247, IL2RA, IL2RB

Publications for Oligoarticular Juvenile Arthritis

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Genetic Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligoarticular Juvenile Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RB, IL2RA
2
Hide members
9.4IL2RB, IL2RA, TYK2
39.4TYK2, IL2RA, IL2RB
4
Hide members
9.3IL2RB, IL2RA, STAT4
59.3IL2RA, IL2RB, TGFB1
69.3STAT4, TYK2, IL2RA
79.1TGFB1, CSF2
8
Hide members
9.0STAT4, TYK2, TGFB1
9
Hide members
9.0STAT4, TYK2, TGFB1
10
Hide members
9.0TGFB1, TYK2, STAT4
119.0IL2RB, IL2RA, CD247, STAT4
128.9STAT4, TYK2, IL2RA, IL2RB
138.9PTPN22, IL2RB, IL2RA, FAS
14
Hide members
8.8IL2RB, IL2RA, TYK2, FAS
15
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8.8CSF2, STAT4, IL2RB
168.8STAT4, CD247, IL2RA, TGFB1
17
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8.7CD247, FAS, CSF2
18
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8.6IL2RB, IL2RA, TYK2, CSF2
19
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8.5IL2RB, IL2RA, CD247, TYK2, STAT4
208.5CSF2, IL2RA, IL2RB, TGFB1
21
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8.4CSF2, FAS, IL2RA, IL2RB
22
Hide members
8.3CSF2, FAS, TYK2, IL2RA
23
Hide members
8.3CSF2, TYK2, IL2RA, IL2RB, PTPN2
24
Hide members
8.2IL2RB, IL2RA, CD247, TYK2, CSF2
258.1CSF2, STAT4, TYK2, IL2RA, IL2RB
26
Hide members
8.0CSF2, STAT4, IL2RA, IL2RB, TGFB1
27
Hide members
7.9CSF2, IL2RA, IL2RB, PTPN22, PTPN2, TGFB1

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1lentinan4410.3IL2RB, IL2RA
2mycophenolate4410.3IL2RB, IL2RA
3thymoglobulin4410.2IL2RA, IL2RB
4denileukin diftitox44 49 1112.2IL2RA, IL2RB
5Aldesleukin1110.2IL2RB, IL2RA
6prednisolone44 28 1112.1IL2RA, IL2RB
7erythromycin44 49 2 1113.1TGFB1, IL2RA
8delta9-tetrahydrocannabinol4410.0IL2RB, IL2RA
9tamoxifen44 49 28 1113.0TGFB1, IL2RB
10daclizumab44 1110.9IL2RB, IL2RA
11serine449.9TGFB1, IL2RB
12basiliximab44 1110.8IL2RA, IL2RB
13dexamethasone44 49 28 1112.8TGFB1, FAS
14infliximab44 49 1111.6FAS, IL2RA, IL2RB
15verapamil44 49 28 11 2413.5TGFB1, IL2RB, IL2RA
16pentoxifylline44 1110.4IL2RB, IL2RA, CSF2
17neopterin449.4IL2RB, IL2RA, CSF2
18phosphotyrosine449.3STAT4, TYK2, IL2RB, PTPN2
19methacholine44 1110.2CSF2, IL2RB, TGFB1
20bleomycin44 1110.2TGFB1, IL2RA, CSF2
211,25 dihydroxy vitamin d3449.1CSF2, IL2RB, TGFB1
22cyclophosphamide44 49 1111.0IL2RB, IL2RA, CSF2
23il 10448.9CSF2, IL2RA, IL2RB, TGFB1
24nifedipine44 49 28 1111.9TGFB1, IL2RB, IL2RA, CSF2
25daunorubicin44 49 1110.9CSF2, FAS, TGFB1
26okt3448.9CSF2, FAS, IL2RA, IL2RB
27ivig448.8IL2RB, IL2RA, FAS, CSF2
28histamine44 28 2410.8TGFB1, IL2RB, IL2RA, CSF2
29ionomycin448.8CSF2, FAS, IL2RA, IL2RB
30gp 130448.8CSF2, FAS, TYK2, IL2RA
31pge2448.7CSF2, IL2RA, IL2RB, TGFB1
32genistein44 28 59 2 11 2413.7IL2RB, IL2RA, FAS, CSF2
33arginine448.7FAS, CD247, IL2RA, IL2RB, PTPN22, PTPN2
34etoposide44 49 59 1111.6CSF2, FAS, IL2RA, TGFB1
35creatinine448.6TGFB1, IL2RB, IL2RA, FAS
36vitamin d448.6TGFB1, IL2RA, FAS, CSF2
37doxorubicin44 49 1110.5CSF2, FAS, IL2RA, TGFB1
38herbimycin a44 599.4CSF2, FAS, IL2RA
39ifn-alpha448.4IL2RB, IL2RA, TYK2, FAS, CSF2
40aspirin44 49 28 2411.3CSF2, FAS, IL2RA, IL2RB, TGFB1
41rantes448.3TGFB1, IL2RB, IL2RA, FAS, CSF2
42polysaccharide448.3CSF2, FAS, IL2RA, IL2RB, TGFB1
43lactate448.3CSF2, FAS, IL2RB, TGFB1
44cyclosporin a44 28 5910.3CSF2, FAS, IL2RA, IL2RB, TGFB1
45cisplatin44 49 59 1111.3CSF2, FAS, IL2RA, IL2RB, TGFB1
46thymidine44 249.3CSF2, FAS, IL2RA, IL2RB, TGFB1
47vegf448.2CSF2, FAS, IL2RA, IL2RB, TGFB1
48retinoic acid44 248.9CSF2, FAS, TYK2, IL2RB, TGFB1
49phosphatidylinositol447.5CSF2, FAS, STAT4, TYK2, CD247, IL2RA
50tyrosine446.9CSF2, FAS, STAT4, TYK2, CD247, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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16Gene Ontology
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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RB, IL2RA, FAS

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:0508609.9PTPN22, PTPN2
2negative regulation of immune responseGO:0507779.7TGFB1, IL2RA
3activation-induced cell death of T cellsGO:0069249.7IL2RA, FAS
4negative regulation of T cell proliferationGO:0421309.7TGFB1, IL2RA
5T cell differentiationGO:0302179.6PTPN2, PTPN22
6cytokine-mediated signaling pathwayGO:0192219.0PTPN2, IL2RB, TYK2, STAT4
7myeloid dendritic cell differentiationGO:0430119.0TGFB1, CSF2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:0199769.8IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.5IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

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Sources for Oligoarticular Juvenile Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet