MCID: OLG015
MIFTS: 33

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Oligoarticular Juvenile Arthritis:

Name: Oligoarticular Juvenile Arthritis 51
Juvenile Pauciarticular Chronic Arthritis 65
 
Pauciarticular Chronic Arthritis 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet51 85410
ICD10 via Orphanet28 M08.4

Summaries for Oligoarticular Juvenile Arthritis

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MalaCards based summary: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to pauciarticular chronic arthritis and oligoarticular juvenile arthritis with anti-nuclear antibodies, and has symptoms including joint swelling, arthralgia and autoimmunity. An important gene associated with Oligoarticular Juvenile Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways are OX40 Pathway and Immune response_IL-12 signaling pathway. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are digestive/alimentary and skeleton.

Related Diseases for Oligoarticular Juvenile Arthritis

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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1pauciarticular chronic arthritis10.6
2oligoarticular juvenile arthritis with anti-nuclear antibodies10.6
3oligoarticular juvenile arthritis without anti-nuclear antibodies10.6
4arthritis10.3
5diabetic ketoacidosis10.3CXCL8, IL6
6eyelid degenerative disease10.3IL10, IL6
7pharyngitis10.3CXCL8, IL10
8rhizomelic chondrodysplasia punctata10.3CXCL8, IL10
9plantar nerve lesion10.3CXCL8, IL6
10malignant sertoli-leydig cell tumor of ovary10.3CXCL8, IL6
11glycogen storage disease viii10.3IL10, IL6
12papilledema10.3CXCL8, IL6
13gastroschisis10.3CSF2, CXCL8
14opisthorchiasis10.3CXCL8, IL10
15cicatricial entropion10.3CXCL8, IL6
16preterm premature rupture of the membranes10.2CXCL8, IL6
17schistosomiasis10.2CXCL8, IL10
18anti-hla hyperimmunization10.2IL6, PTPN22
19plantar fasciitis10.2CXCL8, IL6
20retinal cancer10.2IL10, IL6
21chorioamnionitis10.2CXCL8, IL10, IL6
22fallopian tube transitional cell carcinoma10.2CXCL8, IL10, IL6
23cd3delta deficiency10.2CXCL8, IL10, IL6
24sensorineural hearing loss10.2IL10, IL2RA
25protein-energy malnutrition10.2CXCL8, IL10, IL6
26lumbar plexus neoplasm10.2CXCL8, IL10, IL6
27bubonic plague10.2CXCL8, IL10, IL6
28adult t-cell leukemia10.2CXCL8, IL10, IL6
29benign eccrine breast spiradenoma10.2CXCL8, IL10, IL6
30de quervain disease10.2CXCL8, IL10, IL6
31dentin dysplasia10.2CXCL8, IL10, IL6
32acute mountain sickness10.2CSF2, CXCL8, IL6
33chronic tubotympanic suppurative otitis media10.2CSF2, CXCL8, IL6
34echinostomiasis10.2CSF2, CXCL8, IL6
35bronchopulmonary dysplasia10.2CXCL8, IL10, IL6
36mixed cerebral palsy10.2CXCL8, IL10, IL6
37gastrointestinal anthrax10.2CXCL8, IL10, IL6
38alcoholic liver cirrhosis10.2CXCL8, IL10, IL6
39keratitis10.2CXCL8, IL10, IL6
40hypoglycemic coma10.2CXCL8, IL10, IL6
41vaginal glandular tumor10.2CXCL8, IL6
42perivascular tumor10.2CXCL8, IL10, IL6
43tuberculosis10.2CXCL8, IL10, IL6
44laryngeal abductor paralysis mental retardation10.2CSF2, IL2RA
45dysthymic disorder10.2CXCL8, IL10, IL6
46multicentric osteolysis nephropathy10.2IL10, IL6
47mental depression10.2CXCL8, IL10, IL6
48graft-versus-host disease, protection against10.2IL10, IL2RA
49hairy tongue10.2CXCL8, IL10, IL6
50interstitial nephritis10.2CXCL8, IL10, IL6

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

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Symptoms:

 51
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

HPO human phenotypes related to Oligoarticular Juvenile Arthritis:

id Description Frequency HPO Source Accession
1 joint swelling hallmark (90%) HP:0001386
2 arthralgia hallmark (90%) HP:0002829
3 autoimmunity hallmark (90%) HP:0002960
4 inflammatory abnormality of the eye typical (50%) HP:0100533

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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Drugs for Oligoarticular Juvenile Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Certolizumab pegolapprovedPhase 3109428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
Cimzia
D03441
2TNFR-Fc fusion proteinPhase 3367
3Immunoglobulin Fab FragmentsPhase 385
4
Leflunomideapproved, investigational5975706-12-63899
Synonyms:
210165-51-8
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl
4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl)
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
75706-12-6
A77 1486
AB00052389
AC-6796
AC1L1GYK
AC1Q2EVA
AKOS000265193
AP-501/42475599
Arava
Arava (TN)
Arava, Leflunomide
Aventis Behring Brand of Leflunomide
Aventis Brand of Leflunomide
Aventis Pharma Brand of Leflunomide
BIDD:PXR0189
BPBio1_000930
BRD-K78692225-001-03-9
BSPBio_000844
C045463
C07905
CAS-75706-12-6
CHEBI:6402
CHEMBL960
CID3899
D00749
DB01097
DivK1c_000916
EU-0100649
HMS1570K06
HMS1922M06
HMS2090O12
HMS502N18
HSDB 7289
HWA 486
HWA-486
Hoechst Brand of Leflunomide
I06-2131
IDI1_000916
KBio1_000916
KBio2_000802
KBio2_003370
KBio2_005938
KBioSS_000802
L 5025
L5025_SIGMA
 
LS-86580
Leflunomid
Leflunomida
Leflunomida [INN-Spanish]
Leflunomide
Leflunomide (JAN/USAN/INN)
Leflunomide [USAN:INN]
Leflunomidum
Leflunomidum [INN-Latin]
Lefunomide
Lefunomide [INN-Spanish]
Lefunomide [Inn-Spanish]
Lopac-L-5025
Lopac0_000649
MLS-0003109.0001
MLS000069648
MLS001076267
MolPort-002-345-613
N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
NCGC00015610-01
NCGC00015610-02
NCGC00015610-03
NCGC00015610-07
NCGC00015610-12
NCGC00022625-03
NCGC00022625-04
NCGC00022625-05
NCGC00022625-06
NCGC00022625-07
NCGC00022625-08
NINDS_000916
NSC677411
Prestwick0_000772
Prestwick1_000772
Prestwick2_000772
Prestwick3_000772
Prestwick_87
RS-34821
S1247_Selleck
SMR000058209
SPBio_002783
SPECTRUM1503927
SU 101
SU 101 (pharmaceutical)
SU-101
SU101
Spectrum5_000850
Spectrum_000322
TL8005179
UNII-G162GK9U4W
ZINC00004840
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
leflunomide
lefunamide
5
Methotrexateapproved13871959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
6
Folic Acidapproved, nutraceutical285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7Vitamin B Complex2775
8Cyclosporins849
9Vitamin B9Nutraceutical2851
10FolateNutraceutical2851
11Folinic AcidNutraceutical2498

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
2Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
3Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
4Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic ArthritisTerminatedNCT01261624Phase 2
5Biomarkers in Idiopathic Juvenile ArthritisRecruitingNCT02343770
6Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or MethotrexateRecruitingNCT01399281
7Juvenile Arthritis Quantitative ImagingRecruitingNCT02684695

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

33
Eye, Bone, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Oligoarticular Juvenile Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4FAS, IL10, IL2RA, IL6, PTPN2, PTPN22
2MP:00053908.0CSF2, FAS, IL10, IL6, PTPN2, TYK2
3MP:00053797.4CSF2, FAS, IL10, IL2RB, IL6, PTPN22
4MP:00053847.2CD247, CSF2, FAS, IL10, IL6, PTPN2
5MP:00053786.8CSF2, FAS, IL10, IL2RA, IL2RB, IL6
6MP:00107686.1CD247, CSF2, FAS, IL10, IL2RA, IL2RB
7MP:00053875.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA
8MP:00053975.1CD247, CSF2, CXCL8, FAS, IL10, IL2RA

Publications for Oligoarticular Juvenile Arthritis

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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD247, IL10
29.5IL2RA, STAT4, TYK2
39.4CD247, IL2RA, STAT4
4
Show member pathways
9.3IL6, STAT4, TYK2
5
Show member pathways
9.2CD247, IL2RA, IL2RB, STAT4
69.1IL10, IL6, TYK2
79.1FAS, IL10, IL6
8
Show member pathways
9.0CSF2, IL2RA, IL2RB
9
Show member pathways
8.8CD247, IL2RA, IL2RB, STAT4, TYK2
10
Show member pathways
8.8CD247, IL2RA, IL2RB, STAT4, TYK2
118.8CXCL8, IL10, IL6
12
Show member pathways
8.8IL10, IL6, STAT4, TYK2
138.8CXCL8, IL10, IL6
14
Show member pathways
8.8IL10, IL6, STAT4, TYK2
158.8CSF2, IL2RA, IL6
168.8CSF2, FAS, IL6
17
Show member pathways
8.7CSF2, CXCL8, IL2RA
188.7CXCL8, IL2RA, IL6, STAT4
198.6CSF2, IL10, IL6
208.5CSF2, IL2RA, IL2RB, IL6
218.5CSF2, CXCL8, IL6
22
Salmonella infection (KEGG)
Show member pathways
8.5CSF2, CXCL8, IL6
238.5CSF2, CXCL8, IL6
24
Show member pathways
8.5CSF2, CXCL8, IL6
25
Show member pathways
8.5CXCL8, IL10, IL6, TYK2
268.2CSF2, CXCL8, IL2RB, IL6
27
Show member pathways
8.1CSF2, FAS, IL10, IL2RA, IL2RB
288.1FAS, IL10, IL2RA, IL2RB, PTPN22, STAT4
29
Show member pathways
8.0CXCL8, FAS, IL2RA, IL2RB, IL6, TYK2
30
Show member pathways
8.0CD247, FAS, IL10, IL2RA, IL6, STAT4
318.0CSF2, CXCL8, IL10, IL6
32
B cell receptor signaling pathway (KEGG)
Show member pathways
7.8CSF2, CXCL8, IL10, IL6
33
Show member pathways
7.7CD247, CXCL8, FAS, IL10, IL6, STAT4
34
Show member pathways
7.6CXCL8, IL10, IL2RA, IL2RB, IL6, STAT4
35
Show member pathways
7.1CSF2, IL10, IL2RA, IL2RB, IL6, PTPN2
36
Show member pathways
6.5CSF2, CXCL8, FAS, IL10, IL2RA, IL2RB
37
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA
38
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA
39
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0FAS, IL2RA, IL2RB, IL6

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1interleukin-2-mediated signaling pathwayGO:003811010.6IL2RA, IL2RB
2negative regulation of T cell receptor signaling pathwayGO:005086010.6PTPN2, PTPN22
3activation-induced cell death of T cellsGO:000692410.4FAS, IL2RA
4negative regulation of lipid storageGO:001088810.4IL6, PTPN2
5defense response to protozoanGO:004283210.0IL10, IL6
6positive regulation of JAK-STAT cascadeGO:00464279.9IL10, IL6
7negative regulation of inflammatory responseGO:00507289.9IL10, IL2RA, PTPN2
8response to molecule of bacterial originGO:00022379.7CXCL8, IL10
9response to glucocorticoidGO:00513849.5FAS, IL10, IL6
10cytokine-mediated signaling pathwayGO:00192218.8IL2RB, IL6, PTPN2, STAT4, TYK2
11insulin receptor signaling pathwayGO:00082868.7CSF2, IL2RA, IL2RB, PTPN2
12regulation of cell proliferationGO:00421278.6CSF2, FAS, IL6, TYK2
13inflammatory responseGO:00069548.5CXCL8, FAS, IL10, IL2RA, IL6
14cellular response to lipopolysaccharideGO:00712228.4CSF2, CXCL8, IL10, IL6
15innate immune responseGO:00450878.3CD247, CSF2, IL2RA, IL2RB, TYK2
16immune responseGO:00069557.6CSF2, CXCL8, FAS, IL10, IL2RA, IL6

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:000491110.4IL2RA, IL2RB
2interleukin-2 bindingGO:001997610.4IL2RA, IL2RB
3growth factor activityGO:00080838.6CSF2, IL10, IL6

Sources for Oligoarticular Juvenile Arthritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet