MCID: OLG015
MIFTS: 43

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories
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Summaries for Oligoarticular Juvenile Arthritis

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MalaCards based summary: Oligoarticular Juvenile Arthritis, also known as pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including articular/joint pain/arthralgia, hydrarthrosis/articular/joint effusion and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Oligoarticular Juvenile Arthritis is CD247 (CD247 molecule), and among its related pathways are Inflammatory Response Pathway and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Oligoarticular Juvenile Arthritis, Aliases & Descriptions:

Name: Oligoarticular Juvenile Arthritis 48
 
Pauciarticular Chronic Arthritis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
pauciarticular chronic arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


External Ids:

ICD10 via Orphanet26 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4PTPN22, TGFB1, IL2RB, CSF2
2pauciarticular chronic arthritis10.5
3uveitis10.5IL2RA
4oligoarticular juvenile arthritis with anti-nuclear antibodies10.4
5oligoarticular juvenile arthritis without anti-nuclear antibodies10.4
6t-cell large granular lymphocyte leukemia10.4IL2RB, CSF2
7posterior uveitis10.3IL2RB, IL2RA
8pancytopenia10.3IL2RA, CSF2
9hypereosinophilic syndrome10.3IL2RA, CSF2
10thyroiditis10.3PTPN22
11tropical spastic paraparesis10.3IL2RB, IL2RA
12extrinsic allergic alveolitis10.3IL2RB, IL2RA
13acute graft versus host disease10.3IL2RB, IL2RA
14gamma chain deficiency10.3IL2RA, IL2RB
1521-hydroxylase deficiency10.3IL2RB, IL2RA
16common variable immunodeficiency10.3IL2RB, IL2RA
17hairy cell leukemia10.3IL2RB, IL2RA
18vogt-koyanagi-harada disease10.3IL2RA, FAS
19peripheral t-cell lymphoma10.3IL2RB, IL2RA
20juvenile rheumatoid arthritis10.3IL2RA, IL2RB
21skin disease10.3IL2RA, TGFB1
22pulmonary tuberculosis10.3IL2RA, CD247
23autoimmune lymphoproliferative syndrome10.2IL2RA, FAS
24pneumonia10.2TGFB1, IL2RB, CSF2
25splenomegaly10.2FAS, IL2RA
26pulmonary sarcoidosis10.2CSF2, IL2RB, IL2RA
27keloids10.2FAS, TGFB1
28hepatitis b10.2TGFB1, IL2RA
29diphtheria10.2IL2RA, IL2RB, CSF2
30mycosis fungoides10.2IL2RA, IL2RB
31eosinophilia10.2CSF2, IL2RB, IL2RA
32allergic asthma10.2CSF2, IL2RB, IL2RA
33atopic dermatitis10.2IL2RA, IL2RB, CSF2
34aplastic anemia10.2FAS, CSF2
35anaplastic large cell lymphoma10.2IL2RB, IL2RA
36sezary's disease10.2IL2RB, IL2RA, STAT4
37lupus nephritis10.2IL2RA, TGFB1
38hepatitis10.1IL2RB, FAS, TGFB1
39cutaneous t cell lymphoma10.1FAS, IL2RA, IL2RB
40myeloid leukemia10.1TGFB1, FAS, CSF2
41severe combined immunodeficiency10.1TYK2, IL2RA, IL2RB
42monocytic leukemia10.1CSF2, FAS
43chronic lymphocytic leukemia10.1IL2RB, IL2RA, FAS
44connective tissue disease10.1PTPN22, TGFB1, IL2RA
45hodgkin's lymphoma10.1IL2RA, IL2RB, CSF2, CD247
46t-cell leukemia10.1IL2RB, IL2RA, FAS
47hypersensitivity reaction type ii disease10.1PTPN22, TGFB1, IL2RA
48asthma10.0CSF2, IL2RA, STAT4, TGFB1
49graft versus host disease10.0FAS, IL2RA, IL2RB, CSF2
50ovarian cancer10.0TGFB1, FAS, CSF2, CD247

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

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Symptoms:

48
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

HPO human phenotypes related to Oligoarticular Juvenile Arthritis:

id Description Frequency HPO Source Accession
1 joint swelling hallmark (90%) HP:0001386
2 arthralgia hallmark (90%) HP:0002829
3 autoimmunity hallmark (90%) HP:0002960
4 inflammatory abnormality of the eye typical (50%) HP:0100533

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

32
Eye, Bone, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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Publications for Oligoarticular Juvenile Arthritis

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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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Expression patterns in normal tissues for genes affiliated with Oligoarticular Juvenile Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT537
9.9IL2RB, IL2RA
39.8STAT4, IL2RA
4
Show member pathways
9.5STAT4, IL2RA, IL2RB
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5STAT4, TYK2
69.5STAT4, TYK2
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3CSF2, IL2RA
89.3TGFB1, TYK2
99.3IL2RB, IL2RA, TGFB1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.3CD247, FAS, PTPN2
11
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.2TYK2, IL2RA, IL2RB
129.2IL2RB, IL2RA, TYK2
13
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.2STAT4, IL2RA, IL2RB, CD247
14
Show member pathways
9.2TGFB1, FAS, IL2RA
159.2IL2RA, STAT4, TYK2
169.1CSF2, TGFB1
179.1CSF2, TGFB1
18
Show member pathways
9.1CSF2, TGFB1
19
Show member pathways
9.0IL2RA, TGFB1, TYK2
209.0TGFB1, STAT4, IL2RA, CD247
219.0PTPN22, FAS, IL2RA, IL2RB
22
Show member pathways
9.0STAT4, TGFB1, TYK2
23
Show member pathways
IL27-mediated signaling events37
9.0STAT4, TGFB1, TYK2
24
Show member pathways
9.0TYK2, TGFB1, STAT4
25
Show member pathways
Immune response CD16 signaling in NK cells60
9.0FAS, CSF2, CD247
26
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9TGFB1, FAS, STAT4, CD247
27
Show member pathways
8.8IL2RB, IL2RA, FAS, TYK2
28
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6CD247, IL2RB, IL2RA, STAT4, TYK2
29
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.6TYK2, STAT4, IL2RA, IL2RB, CD247
308.5TGFB1, IL2RA, IL2RB, CSF2
31
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.4CD247, CSF2, FAS, TGFB1
32
Show member pathways
8.4TYK2, IL2RA, IL2RB, CSF2
33
Show member pathways
8.4TYK2, TGFB1, STAT4, IL2RA, IL2RB
34
Show member pathways
8.2TGFB1, STAT4, IL2RA, IL2RB, CSF2
35
Show member pathways
8.2CSF2, IL2RB, IL2RA, STAT4, TGFB1
36
Show member pathways
8.1CSF2, IL2RB, IL2RA, FAS, TGFB1
37
Show member pathways
Type III interferon signaling37
8.1CSF2, IL2RB, IL2RA, STAT4, TYK2
38
Show member pathways
7.9TYK2, PTPN2, IL2RA, IL2RB, CSF2
39
Show member pathways
7.5PTPN2, PTPN22, TGFB1, IL2RA, IL2RB, CSF2
40
Show member pathways
7.5TYK2, TGFB1, FAS, IL2RA, IL2RB, CSF2

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

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Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1lentinan4410.3IL2RB, IL2RA
2mycophenolate4410.3IL2RB, IL2RA
3thymoglobulin4410.2IL2RB, IL2RA
4denileukin diftitox44 50 1112.1IL2RB, IL2RA
5delta9-tetrahydrocannabinol449.9IL2RB, IL2RA
6basiliximab44 1110.9IL2RA, IL2RB
7infliximab44 50 1111.8FAS, IL2RA, IL2RB
8erythromycin44 2 50 1112.7IL2RA, TGFB1, IL2RB
9prednisolone44 28 1111.6FAS, IL2RA, IL2RB
10daclizumab44 1110.6IL2RA, IL2RB
11verapamil44 28 50 24 1113.5TGFB1, IL2RB, IL2RA
12pentoxifylline44 1110.4CSF2, IL2RB, IL2RA
13neopterin449.4IL2RB, CSF2, IL2RA
14methacholine44 50 1111.2TGFB1, CSF2, IL2RB
15rituximab44 50 1111.1CSF2, IL2RA, TGFB1
16bleomycin44 1110.1CSF2, IL2RA, TGFB1
17phosphotyrosine449.1TYK2, PTPN2, STAT4, IL2RB
181,25 dihydroxy vitamin d3449.1IL2RB, CSF2, TGFB1
19okt3449.1IL2RA, FAS, CSF2, IL2RB
20ivig449.1CSF2, IL2RB, IL2RA, FAS
21daunorubicin44 50 1111.0TGFB1, FAS, CSF2
22creatinine449.0FAS, IL2RA, IL2RB, TGFB1
23ionomycin449.0IL2RA, IL2RB, CSF2, FAS
24il 10449.0IL2RB, CSF2, IL2RA, TGFB1
25nifedipine44 28 50 1111.9TGFB1, CSF2, IL2RB, IL2RA
26herbimycin a44 619.9IL2RA, CSF2, FAS
27genistein44 28 61 2 24 1113.9IL2RA, CSF2, FAS, IL2RB
28histamine44 28 2410.8TGFB1, CSF2, IL2RB, IL2RA
29etoposide44 50 61 1111.8CSF2, IL2RA, FAS, TGFB1
30tamoxifen44 50 28 1111.8CSF2, IL2RB, FAS, TGFB1
31vitamin d448.8TGFB1, FAS, CSF2, IL2RA
32pge2448.7CSF2, IL2RA, IL2RB, TGFB1
33gp 130448.7IL2RA, FAS, TYK2, CSF2
34doxorubicin44 50 1110.7TGFB1, FAS, IL2RA, CSF2
35lactate448.6CSF2, FAS, IL2RB, TGFB1
36arginine448.6PTPN22, PTPN2, CD247, IL2RB, FAS, IL2RA
37aspirin44 50 28 2411.5CSF2, IL2RA, FAS, TGFB1, IL2RB
38rantes448.5FAS, TGFB1, IL2RA, IL2RB, CSF2
39polysaccharide448.5TGFB1, FAS, IL2RB, IL2RA, CSF2
40cyclosporin a44 28 6110.5FAS, IL2RA, CSF2, IL2RB, TGFB1
41thymidine44 249.5IL2RB, TGFB1, FAS, IL2RA, CSF2
42cisplatin44 50 61 1111.5CSF2, IL2RA, TGFB1, FAS, IL2RB
43vegf448.5IL2RB, IL2RA, FAS, TGFB1, CSF2
44ifn-alpha448.5CSF2, IL2RB, IL2RA, TYK2, FAS
45cycloheximide448.3FAS, CSF2, TGFB1, IL2RB
46dexamethasone44 50 28 1111.2IL2RA, TGFB1, CSF2, STAT4, IL2RB, FAS
47serine448.1FAS, STAT4, IL2RB, TYK2, PTPN2, TGFB1
48retinoic acid44 249.1CSF2, IL2RB, TGFB1, TYK2, FAS
49phosphatidylinositol447.8TYK2, IL2RB, CD247, CSF2, IL2RA, STAT4
50tyrosine446.8PTPN22, TYK2, PTPN2, FAS, STAT4, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL2RB, IL2RA, FAS
2plasma membraneGO:0058868.1CD247, IL2RB, IL2RA, FAS, TGFB1, PTPN2

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.9FAS, IL2RA
2negative regulation of immune responseGO:0507779.8IL2RA, TGFB1
3negative regulation of T cell receptor signaling pathwayGO:0508609.6PTPN22, PTPN2
4negative regulation of T cell proliferationGO:0421309.5IL2RA, TGFB1
5T cell differentiationGO:0302179.5PTPN22, PTPN2
6extrinsic apoptotic signaling pathwayGO:0971919.2TGFB1, FAS
7myeloid dendritic cell differentiationGO:0430119.2TGFB1, CSF2
8protein phosphorylationGO:0064689.0STAT4, TGFB1, TYK2
9cytokine-mediated signaling pathwayGO:0192218.9IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2kinase bindingGO:0199009.6FAS, PTPN22
3interleukin-2 bindingGO:0199769.6IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Oligoarticular Juvenile Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet