MCID: OLG015
MIFTS: 43

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Oligoarticular Juvenile Arthritis

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including articular/joint pain/arthralgia, hydrarthrosis/articular/joint effusion and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Oligoarticular Juvenile Arthritis is CD247 (CD247 molecule), and among its related pathways are Inflammatory Response Pathway and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

About this section
Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

oligoarticular juvenile arthritis 50
juvenile pauciarticular chronic arthritis 63
pauciarticular chronic arthritis 50


External Ids:

ICD10 via Orphanet27 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4CSF2, TGFB1, PTPN22, IL2RB
2pauciarticular chronic arthritis10.5
3oligoarticular juvenile arthritis with anti-nuclear antibodies10.4
4oligoarticular juvenile arthritis without anti-nuclear antibodies10.4
5uveitis10.1IL2RA
6t-cell large granular lymphocyte leukemia10.1CSF2, IL2RB
7pancytopenia10.1IL2RA, CSF2
8posterior uveitis10.1IL2RA, IL2RB
9hypereosinophilic syndrome10.1CSF2, IL2RA
10thyroiditis10.1PTPN22
11tropical spastic paraparesis10.1IL2RA, IL2RB
12immunodeficiency, common variable, 710.1IL2RB, IL2RA
13extrinsic allergic alveolitis10.1IL2RB, IL2RA
14acute graft versus host disease10.1IL2RB, IL2RA
15gamma chain deficiency10.1IL2RA, IL2RB
16congenital stationary night blindness, type 1f10.1IL2RB, IL2RA
17common variable immune deficiency10.1IL2RA, IL2RB
18hairy cell leukemia10.1IL2RA, IL2RB
19vogt-koyanagi-harada disease10.1FAS, IL2RA
20peripheral t-cell lymphoma10.1IL2RA, IL2RB
21juvenile rheumatoid arthritis10.1IL2RB, IL2RA
22pulmonary tuberculosis10.1CD247, IL2RA
23skin disease10.1IL2RA, TGFB1
24autoimmune lymphoproliferative syndrome10.1IL2RA, FAS
25hepatitis b10.1TGFB1, IL2RA
26pneumonia10.1IL2RB, TGFB1, CSF2
27pulmonary sarcoidosis10.1CSF2, IL2RA, IL2RB
28splenomegaly10.1IL2RA, FAS
29keloids10.1TGFB1, FAS
30diphtheria10.0IL2RA, IL2RB, CSF2
31eosinophilia10.0CSF2, IL2RB, IL2RA
32mycosis fungoides10.0IL2RA, IL2RB
33allergic asthma10.0CSF2, IL2RB, IL2RA
34atopic dermatitis10.0CSF2, IL2RB, IL2RA
35anaplastic large cell lymphoma10.0IL2RA, IL2RB
36sezary's disease10.0STAT4, IL2RA, IL2RB
37lupus nephritis10.0TGFB1, IL2RA
38aplastic anemia10.0CSF2, FAS
39hepatitis10.0IL2RB, TGFB1, FAS
40cutaneous t cell lymphoma10.0IL2RB, FAS, IL2RA
41myeloid leukemia10.0TGFB1, FAS, CSF2
42severe combined immunodeficiency10.0IL2RA, TYK2, IL2RB
43monocytic leukemia10.0FAS, CSF2
44b-cell chronic lymphocytic leukemia10.0IL2RB, FAS, IL2RA
45connective tissue disease10.0PTPN22, TGFB1, IL2RA
46t-cell leukemia10.0IL2RB, FAS, IL2RA
47hodgkin's lymphoma10.0CD247, CSF2, IL2RB, IL2RA
48hypersensitivity reaction type ii disease10.0TGFB1, IL2RA, PTPN22
49asthma10.0TGFB1, CSF2, IL2RA, STAT4
50ovarian cancer10.0TGFB1, FAS, CD247, CSF2

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

About this section
Sources:
50Orphanet
See all sources


Symptoms:

50
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oligoarticular Juvenile Arthritis

Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Search CenterWatch for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

About this section

Anatomical Context for Oligoarticular Juvenile Arthritis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

34
Eye, Bone, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

About this section
Sources:
38MGI
See all sources

Publications for Oligoarticular Juvenile Arthritis

About this section
Sources:
53PubMed
See all sources

Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

About this section

Expression for genes affiliated with Oligoarticular Juvenile Arthritis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oligoarticular Juvenile Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 5Cell Signaling Technology, 61Thomson Reuters, 31KEGG, 56Reactome, 55R&D Systems
See all sources

Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT539
9.9IL2RB, IL2RA
39.8STAT4, IL2RA
4
Show member pathways
9.5STAT4, IL2RA, IL2RB
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.5STAT4, TYK2
69.5STAT4, TYK2
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3CSF2, IL2RA
89.3TGFB1, TYK2
99.3IL2RB, IL2RA, TGFB1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.3CD247, FAS, PTPN2
11
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.2TYK2, IL2RA, IL2RB
129.2IL2RB, IL2RA, TYK2
13
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.2STAT4, IL2RA, IL2RB, CD247
14
Show member pathways
9.2TGFB1, FAS, IL2RA
159.2IL2RA, STAT4, TYK2
169.1CSF2, TGFB1
179.1CSF2, TGFB1
18
Show member pathways
9.1CSF2, TGFB1
19
Show member pathways
9.0IL2RA, TGFB1, TYK2
209.0TGFB1, STAT4, IL2RA, CD247
219.0PTPN22, FAS, IL2RA, IL2RB
22
Show member pathways
9.0STAT4, TGFB1, TYK2
23
Show member pathways
IL27-mediated signaling events39
9.0STAT4, TGFB1, TYK2
24
Show member pathways
9.0TYK2, TGFB1, STAT4
25
Show member pathways
Immune response CD16 signaling in NK cells61
9.0FAS, CSF2, CD247
26
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.9TGFB1, FAS, STAT4, CD247
27
Show member pathways
8.8IL2RB, IL2RA, FAS, TYK2
28
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
8.6CD247, IL2RB, IL2RA, STAT4, TYK2
29
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.6TYK2, STAT4, IL2RA, IL2RB, CD247
308.5TGFB1, IL2RA, IL2RB, CSF2
31
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.4CD247, CSF2, FAS, TGFB1
32
Show member pathways
8.4TYK2, IL2RA, IL2RB, CSF2
33
Show member pathways
8.4TYK2, TGFB1, STAT4, IL2RA, IL2RB
34
Show member pathways
8.2TGFB1, STAT4, IL2RA, IL2RB, CSF2
35
Show member pathways
8.2CSF2, IL2RB, IL2RA, STAT4, TGFB1
36
Show member pathways
8.1CSF2, IL2RB, IL2RA, FAS, TGFB1
37
Show member pathways
Type III interferon signaling39
8.1CSF2, IL2RB, IL2RA, STAT4, TYK2
38
Show member pathways
7.9TYK2, PTPN2, IL2RA, IL2RB, CSF2
39
Show member pathways
7.5PTPN2, PTPN22, TGFB1, IL2RA, IL2RB, CSF2
40
Show member pathways
7.5TYK2, TGFB1, FAS, IL2RA, IL2RB, CSF2

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
See all sources

Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1lentinan4610.3IL2RB, IL2RA
2mycophenolate4610.3IL2RB, IL2RA
3thymoglobulin4610.2IL2RB, IL2RA
4denileukin diftitox46 52 1212.1IL2RB, IL2RA
5delta9-tetrahydrocannabinol469.9IL2RB, IL2RA
6basiliximab46 1210.9IL2RA, IL2RB
7infliximab46 52 1211.8FAS, IL2RA, IL2RB
8erythromycin46 3 52 1212.7IL2RA, TGFB1, IL2RB
9prednisolone46 30 1211.6FAS, IL2RA, IL2RB
10daclizumab46 1210.6IL2RA, IL2RB
11verapamil46 30 52 25 1213.5TGFB1, IL2RB, IL2RA
12pentoxifylline46 1210.4CSF2, IL2RB, IL2RA
13neopterin469.4IL2RB, CSF2, IL2RA
14methacholine46 52 1211.2TGFB1, CSF2, IL2RB
15rituximab46 52 1211.1CSF2, IL2RA, TGFB1
16bleomycin46 1210.1CSF2, IL2RA, TGFB1
17phosphotyrosine469.1TYK2, PTPN2, STAT4, IL2RB
181,25 dihydroxy vitamin d3469.1IL2RB, CSF2, TGFB1
19okt3469.1IL2RA, FAS, CSF2, IL2RB
20ivig469.1CSF2, IL2RB, IL2RA, FAS
21daunorubicin46 52 1211.0TGFB1, FAS, CSF2
22creatinine469.0FAS, IL2RA, IL2RB, TGFB1
23ionomycin469.0IL2RA, IL2RB, CSF2, FAS
24il 10469.0IL2RB, CSF2, IL2RA, TGFB1
25nifedipine46 30 52 1211.9TGFB1, CSF2, IL2RB, IL2RA
26herbimycin a46 629.9IL2RA, CSF2, FAS
27genistein46 30 62 3 25 1213.9IL2RA, CSF2, FAS, IL2RB
28histamine46 30 2510.8TGFB1, CSF2, IL2RB, IL2RA
29etoposide46 52 62 1211.8CSF2, IL2RA, FAS, TGFB1
30tamoxifen46 52 30 1211.8CSF2, IL2RB, FAS, TGFB1
31vitamin d468.8TGFB1, FAS, CSF2, IL2RA
32pge2468.7CSF2, IL2RA, IL2RB, TGFB1
33gp 130468.7IL2RA, FAS, TYK2, CSF2
34doxorubicin46 52 1210.7TGFB1, FAS, IL2RA, CSF2
35lactate468.6CSF2, FAS, IL2RB, TGFB1
36arginine468.6PTPN22, PTPN2, CD247, IL2RB, FAS, IL2RA
37aspirin46 52 30 2511.5CSF2, IL2RA, FAS, TGFB1, IL2RB
38rantes468.5FAS, TGFB1, IL2RA, IL2RB, CSF2
39polysaccharide468.5TGFB1, FAS, IL2RB, IL2RA, CSF2
40cyclosporin a46 30 6210.5FAS, IL2RA, CSF2, IL2RB, TGFB1
41thymidine46 259.5IL2RB, TGFB1, FAS, IL2RA, CSF2
42cisplatin46 52 62 1211.5CSF2, IL2RA, TGFB1, FAS, IL2RB
43vegf468.5IL2RB, IL2RA, FAS, TGFB1, CSF2
44ifn-alpha468.5CSF2, IL2RB, IL2RA, TYK2, FAS
45cycloheximide468.3FAS, CSF2, TGFB1, IL2RB
46dexamethasone46 52 30 1211.2IL2RA, TGFB1, CSF2, STAT4, IL2RB, FAS
47serine468.1FAS, STAT4, IL2RB, TYK2, PTPN2, TGFB1
48retinoic acid46 259.1CSF2, IL2RB, TGFB1, TYK2, FAS
49phosphatidylinositol467.8TYK2, IL2RB, CD247, CSF2, IL2RA, STAT4
50tyrosine466.8PTPN22, TYK2, PTPN2, FAS, STAT4, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL2RB, IL2RA, FAS
2plasma membraneGO:0058868.1CD247, IL2RB, IL2RA, FAS, TGFB1, PTPN2

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.9FAS, IL2RA
2negative regulation of immune responseGO:0507779.8IL2RA, TGFB1
3negative regulation of T cell receptor signaling pathwayGO:0508609.6PTPN22, PTPN2
4negative regulation of T cell proliferationGO:0421309.5IL2RA, TGFB1
5T cell differentiationGO:0302179.5PTPN22, PTPN2
6extrinsic apoptotic signaling pathwayGO:0971919.2TGFB1, FAS
7myeloid dendritic cell differentiationGO:0430119.2TGFB1, CSF2
8protein phosphorylationGO:0064689.0STAT4, TGFB1, TYK2
9cytokine-mediated signaling pathwayGO:0192218.9IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2kinase bindingGO:0199009.6FAS, PTPN22
3interleukin-2 bindingGO:0199769.6IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligoarticular Juvenile Arthritis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet