MCID: OLG015
MIFTS: 37

Oligoarticular Juvenile Arthritis malady

Eye, Respiratory, Bone categories

Summaries for Oligoarticular Juvenile Arthritis

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33MalaCards
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MalaCards: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including articular/joint pain/arthralgia, hydrarthrosis/articular/joint effusion and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Oligoarticular Juvenile Arthritis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Inflammatory Response Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

oligoarticular juvenile arthritis 49
juvenile pauciarticular chronic arthritis 61
pauciarticular chronic arthritis 49


External Ids:

ICD10 via Orphanet26 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Oligoarticular Juvenile Arthritis family:

oligoarticular juvenile arthritis with anti-nuclear antibodies oligoarticular juvenile arthritis without anti-nuclear antibodies

Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3CSF2, IL2RB, PTPN22, TGFB1
2pauciarticular chronic arthritis10.5
3oligoarticular juvenile arthritis with anti-nuclear antibodies10.4
4oligoarticular juvenile arthritis without anti-nuclear antibodies10.4
5deficiency anemia10.0CSF2
6hemophagocytic lymphohistiocytosis10.0IL2RA
7tuberculosis10.0IL2RA
8acquired immunodeficiency syndrome10.0CSF2
9inflammatory bowel disease10.0TGFB1
10crohn's disease10.0PTPN2
11acute leukemia10.0CSF2
12pancreatitis10.0TGFB1
13uveitis10.0IL2RA
14dermatitis10.0CSF2
15thrombocytopenia10.0CSF2
16celiac disease10.0PTPN22
17nephrotic syndrome10.0IL2RA
18vitiligo10.0PTPN22
19thyroiditis10.0PTPN22
20pulmonary fibrosis10.0TGFB1
21liver cirrhosis10.0TGFB1
22glomerulonephritis10.0TGFB1
23influenza10.0IL2RB
24malaria10.0IL2RB
25eye disease10.0TGFB1
26hyperthyroidism10.0PTPN22
27neutropenia10.0CSF2
28osteoarthritis10.0TGFB1
29lupus nephritis10.0TGFB1, IL2RA
30viral hepatitis10.0FAS
31common variable immune deficiency10.0IL2RB, IL2RA
32sarcoidosis10.0IL2RA, IL2RB
33tetanus10.0CSF2, IL2RA
34obesity10.0PTPN2
35diabetes mellitus10.0TGFB1, PTPN22
36psoriasis10.0PTPN22, IL2RA
37posterior uveitis10.0IL2RB, IL2RA
38t-cell large granular lymphocyte leukemia10.0CSF2, IL2RB
39systemic lupus erythematosus10.0STAT4
40sjogren's syndrome10.0FAS, IL2RA
41mycosis fungoides10.0IL2RB, IL2RA
42tropical spastic paraparesis10.0IL2RB, IL2RA
43vogt-koyanagi-harada disease10.0IL2RA, FAS
44immunodeficiency, common variable, 710.0IL2RB, IL2RA
45extrinsic allergic alveolitis10.0IL2RB, IL2RA
46encephalomyelitis10.0STAT4
47hepatocellular carcinoma10.0FAS, TGFB1
48acute graft versus host disease10.0IL2RA, IL2RB
49adenocarcinoma10.0TGFB1, FAS
50myelodysplastic syndromes10.0FAS, CSF2

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Clinical Features for Oligoarticular Juvenile Arthritis

Sources:
49Orphanet
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Symptoms:

49 (see all 5)
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oligoarticular Juvenile Arthritis

Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Search CenterWatch for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

Anatomical Context for Oligoarticular Juvenile Arthritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

33
T cells, B cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Oligoarticular Juvenile Arthritis

Sources:
51PubMed
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Articles related to Oligoarticular Juvenile Arthritis:

(show all 18)
idTitleAuthorsYear
1
The role of TGFI^ signaling in fibroblast-like synoviocytes from oligoarticular juvenile idiopathic arthritis. (24375380)
2013
2
Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis. (24131380)
2013
3
Oligoarticular juvenile idiopathic arthritis among Saudi children. (24413854)
2013
4
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. (23696632)
2013
5
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. (21707991)
2011
6
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. (19933594)
2010
7
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. (19804628)
2009
8
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. (18078632)
2007
9
The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. (15703957)
2006
10
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. (15641099)
2005
11
TNF-alpha promoter gene polymorphisms in Spanish children with persistent oligoarticular and systemic-onset juvenile idiopathic arthritis. (16393767)
2005
12
Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis. (12136915)
2002
13
The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis. (12384930)
2002
14
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. (11371669)
2001
15
Isolated tuberculous monoarthritis mimicking oligoarticular juvenile rheumatoid arthritis. (11196526)
2001
16
Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. (10342632)
1999
17
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997
18
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. (8912504)
1996

Genetic Variations for Oligoarticular Juvenile Arthritis

Expression for genes affiliated with Oligoarticular Juvenile Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oligoarticular Juvenile Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

Sources:
38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology, 52QIAGEN, 30KEGG, 12EMD Millipore, 54Reactome
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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RB, IL2RA
2
Hide members
9.4IL2RB, IL2RA, TYK2
39.4TYK2, IL2RA, IL2RB
4
Hide members
9.3IL2RB, IL2RA, STAT4
59.3IL2RA, IL2RB, TGFB1
69.3STAT4, TYK2, IL2RA
79.1TGFB1, CSF2
8
Hide members
9.0STAT4, TYK2, TGFB1
9
Hide members
9.0STAT4, TYK2, TGFB1
10
Hide members
9.0TGFB1, TYK2, STAT4
119.0IL2RB, IL2RA, CD247, STAT4
128.9STAT4, TYK2, IL2RA, IL2RB
138.9PTPN22, IL2RB, IL2RA, FAS
14
Hide members
8.8IL2RB, IL2RA, TYK2, FAS
15
Hide members
8.8CSF2, STAT4, IL2RB
168.8STAT4, CD247, IL2RA, TGFB1
17
Hide members
8.7CD247, FAS, CSF2
18
Hide members
8.6IL2RB, IL2RA, TYK2, CSF2
19
Hide members
8.5IL2RB, IL2RA, CD247, TYK2, STAT4
208.5CSF2, IL2RA, IL2RB, TGFB1
21
Hide members
8.4CSF2, FAS, IL2RA, IL2RB
22
Hide members
8.3CSF2, FAS, TYK2, IL2RA
23
Hide members
8.3CSF2, TYK2, IL2RA, IL2RB, PTPN2
24
Hide members
8.2IL2RB, IL2RA, CD247, TYK2, CSF2
258.1CSF2, STAT4, TYK2, IL2RA, IL2RB
26
Hide members
8.0CSF2, STAT4, IL2RA, IL2RB, TGFB1
27
Hide members
7.9CSF2, IL2RA, IL2RB, PTPN22, PTPN2, TGFB1

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1lentinan4510.3IL2RB, IL2RA
2mycophenolate4510.3IL2RB, IL2RA
3thymoglobulin4510.2IL2RA, IL2RB
4denileukin diftitox45 50 1112.2IL2RA, IL2RB
5Aldesleukin1110.2IL2RB, IL2RA
6prednisolone45 29 1112.1IL2RA, IL2RB
7erythromycin45 50 2 1113.1TGFB1, IL2RA
8delta9-tetrahydrocannabinol4510.0IL2RB, IL2RA
9tamoxifen45 50 29 1113.0TGFB1, IL2RB
10daclizumab45 1110.9IL2RB, IL2RA
11serine459.9TGFB1, IL2RB
12basiliximab45 1110.8IL2RA, IL2RB
13dexamethasone45 50 29 1112.8TGFB1, FAS
14infliximab45 50 1111.6FAS, IL2RA, IL2RB
15verapamil45 50 29 11 2413.5TGFB1, IL2RB, IL2RA
16pentoxifylline45 1110.4IL2RB, IL2RA, CSF2
17neopterin459.4IL2RB, IL2RA, CSF2
18phosphotyrosine459.3STAT4, TYK2, IL2RB, PTPN2
19methacholine45 1110.2CSF2, IL2RB, TGFB1
20bleomycin45 1110.2TGFB1, IL2RA, CSF2
211,25 dihydroxy vitamin d3459.1CSF2, IL2RB, TGFB1
22cyclophosphamide45 50 1111.0IL2RB, IL2RA, CSF2
23il 10458.9CSF2, IL2RA, IL2RB, TGFB1
24nifedipine45 50 29 1111.9TGFB1, IL2RB, IL2RA, CSF2
25daunorubicin45 50 1110.9CSF2, FAS, TGFB1
26okt3458.9CSF2, FAS, IL2RA, IL2RB
27ivig458.8IL2RB, IL2RA, FAS, CSF2
28histamine45 29 2410.8TGFB1, IL2RB, IL2RA, CSF2
29ionomycin458.8CSF2, FAS, IL2RA, IL2RB
30gp 130458.8CSF2, FAS, TYK2, IL2RA
31pge2458.7CSF2, IL2RA, IL2RB, TGFB1
32genistein45 29 60 2 11 2413.7IL2RB, IL2RA, FAS, CSF2
33arginine458.7FAS, CD247, IL2RA, IL2RB, PTPN22, PTPN2
34etoposide45 50 60 1111.6CSF2, FAS, IL2RA, TGFB1
35creatinine458.6TGFB1, IL2RB, IL2RA, FAS
36vitamin d458.6TGFB1, IL2RA, FAS, CSF2
37doxorubicin45 50 1110.5CSF2, FAS, IL2RA, TGFB1
38herbimycin a45 609.4CSF2, FAS, IL2RA
39ifn-alpha458.4IL2RB, IL2RA, TYK2, FAS, CSF2
40aspirin45 50 29 2411.3CSF2, FAS, IL2RA, IL2RB, TGFB1
41rantes458.3TGFB1, IL2RB, IL2RA, FAS, CSF2
42polysaccharide458.3CSF2, FAS, IL2RA, IL2RB, TGFB1
43lactate458.3CSF2, FAS, IL2RB, TGFB1
44cyclosporin a45 29 6010.3CSF2, FAS, IL2RA, IL2RB, TGFB1
45cisplatin45 50 60 1111.3CSF2, FAS, IL2RA, IL2RB, TGFB1
46thymidine45 249.3CSF2, FAS, IL2RA, IL2RB, TGFB1
47vegf458.2CSF2, FAS, IL2RA, IL2RB, TGFB1
48retinoic acid45 248.9CSF2, FAS, TYK2, IL2RB, TGFB1
49phosphatidylinositol457.5CSF2, FAS, STAT4, TYK2, CD247, IL2RA
50tyrosine456.9CSF2, FAS, STAT4, TYK2, CD247, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RB, IL2RA, FAS

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:0508609.9PTPN22, PTPN2
2negative regulation of immune responseGO:0507779.7TGFB1, IL2RA
3activation-induced cell death of T cellsGO:0069249.7IL2RA, FAS
4negative regulation of T cell proliferationGO:0421309.7TGFB1, IL2RA
5T cell differentiationGO:0302179.6PTPN2, PTPN22
6cytokine-mediated signaling pathwayGO:0192219.0PTPN2, IL2RB, TYK2, STAT4
7myeloid dendritic cell differentiationGO:0430119.0TGFB1, CSF2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:0199769.8IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.5IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligoarticular Juvenile Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet