MCID: OLG015
MIFTS: 43

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories
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Summaries for Oligoarticular Juvenile Arthritis

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33MalaCards
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MalaCards: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including articular/joint pain/arthralgia, hydrarthrosis/articular/joint effusion and autoimmunity/autoimmune reaction/autoantibodies. An important gene associated with Oligoarticular Juvenile Arthritis is CD247 (CD247 molecule), and among its related pathways are Inflammatory Response Pathway and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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49Orphanet, 62UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

49
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

oligoarticular juvenile arthritis 49
juvenile pauciarticular chronic arthritis 62
pauciarticular chronic arthritis 49


External Ids:

ICD10 via Orphanet26 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4CSF2, TGFB1, PTPN22, IL2RB
2pauciarticular chronic arthritis10.5
3oligoarticular juvenile arthritis with anti-nuclear antibodies10.4
4oligoarticular juvenile arthritis without anti-nuclear antibodies10.4
5uveitis10.1IL2RA
6t-cell large granular lymphocyte leukemia10.1CSF2, IL2RB
7pancytopenia10.1IL2RA, CSF2
8posterior uveitis10.1IL2RA, IL2RB
9hypereosinophilic syndrome10.1CSF2, IL2RA
10thyroiditis10.1PTPN22
11tropical spastic paraparesis10.1IL2RA, IL2RB
12immunodeficiency, common variable, 710.1IL2RB, IL2RA
13extrinsic allergic alveolitis10.1IL2RB, IL2RA
14acute graft versus host disease10.1IL2RB, IL2RA
15gamma chain deficiency10.1IL2RA, IL2RB
16congenital stationary night blindness, type 1f10.1IL2RB, IL2RA
17common variable immune deficiency10.1IL2RA, IL2RB
18hairy cell leukemia10.1IL2RA, IL2RB
19vogt-koyanagi-harada disease10.1FAS, IL2RA
20peripheral t-cell lymphoma10.1IL2RA, IL2RB
21juvenile rheumatoid arthritis10.1IL2RB, IL2RA
22pulmonary tuberculosis10.1CD247, IL2RA
23skin disease10.1IL2RA, TGFB1
24autoimmune lymphoproliferative syndrome10.1IL2RA, FAS
25hepatitis b10.1TGFB1, IL2RA
26pneumonia10.1IL2RB, TGFB1, CSF2
27pulmonary sarcoidosis10.1CSF2, IL2RA, IL2RB
28splenomegaly10.1IL2RA, FAS
29keloids10.1TGFB1, FAS
30diphtheria10.0IL2RA, IL2RB, CSF2
31eosinophilia10.0CSF2, IL2RB, IL2RA
32mycosis fungoides10.0IL2RA, IL2RB
33allergic asthma10.0CSF2, IL2RB, IL2RA
34atopic dermatitis10.0CSF2, IL2RB, IL2RA
35anaplastic large cell lymphoma10.0IL2RA, IL2RB
36sezary's disease10.0STAT4, IL2RA, IL2RB
37lupus nephritis10.0TGFB1, IL2RA
38aplastic anemia10.0CSF2, FAS
39hepatitis10.0IL2RB, TGFB1, FAS
40cutaneous t cell lymphoma10.0IL2RB, FAS, IL2RA
41myeloid leukemia10.0TGFB1, FAS, CSF2
42severe combined immunodeficiency10.0IL2RA, TYK2, IL2RB
43monocytic leukemia10.0FAS, CSF2
44b-cell chronic lymphocytic leukemia10.0IL2RB, FAS, IL2RA
45connective tissue disease10.0PTPN22, TGFB1, IL2RA
46t-cell leukemia10.0IL2RB, FAS, IL2RA
47hodgkin's lymphoma10.0CD247, CSF2, IL2RB, IL2RA
48hypersensitivity reaction type ii disease10.0TGFB1, IL2RA, PTPN22
49asthma10.0TGFB1, CSF2, IL2RA, STAT4
50ovarian cancer10.0TGFB1, FAS, CD247, CSF2

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

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49Orphanet
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Symptoms:

49
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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33MalaCards
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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

33
Eye, Bone, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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37MGI
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Publications for Oligoarticular Juvenile Arthritis

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52PubMed
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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligoarticular Juvenile Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology, 60Thomson Reuters, 30KEGG, 55Reactome, 54R&D Systems
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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT538
9.9IL2RB, IL2RA
39.8STAT4, IL2RA
4
Show member pathways
9.5STAT4, IL2RA, IL2RB
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5STAT4, TYK2
69.5STAT4, TYK2
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.3CSF2, IL2RA
89.3TGFB1, TYK2
99.3IL2RB, IL2RA, TGFB1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.3CD247, FAS, PTPN2
11
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2TYK2, IL2RA, IL2RB
129.2IL2RB, IL2RA, TYK2
13
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.2STAT4, IL2RA, IL2RB, CD247
14
Show member pathways
9.2TGFB1, FAS, IL2RA
159.2IL2RA, STAT4, TYK2
169.1CSF2, TGFB1
179.1CSF2, TGFB1
18
Show member pathways
9.1CSF2, TGFB1
19
Show member pathways
9.0IL2RA, TGFB1, TYK2
209.0TGFB1, STAT4, IL2RA, CD247
219.0PTPN22, FAS, IL2RA, IL2RB
22
Show member pathways
9.0STAT4, TGFB1, TYK2
23
Show member pathways
IL27-mediated signaling events38
9.0STAT4, TGFB1, TYK2
24
Show member pathways
9.0TYK2, TGFB1, STAT4
25
Show member pathways
Immune response CD16 signaling in NK cells60
9.0FAS, CSF2, CD247
26
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9TGFB1, FAS, STAT4, CD247
27
Show member pathways
8.8IL2RB, IL2RA, FAS, TYK2
28
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6CD247, IL2RB, IL2RA, STAT4, TYK2
29
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.6TYK2, STAT4, IL2RA, IL2RB, CD247
308.5TGFB1, IL2RA, IL2RB, CSF2
31
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.4CD247, CSF2, FAS, TGFB1
32
Show member pathways
8.4TYK2, IL2RA, IL2RB, CSF2
33
Show member pathways
8.4TYK2, TGFB1, STAT4, IL2RA, IL2RB
34
Show member pathways
8.2TGFB1, STAT4, IL2RA, IL2RB, CSF2
35
Show member pathways
8.2CSF2, IL2RB, IL2RA, STAT4, TGFB1
36
Show member pathways
8.1CSF2, IL2RB, IL2RA, FAS, TGFB1
37
Show member pathways
Type III interferon signaling38
8.1CSF2, IL2RB, IL2RA, STAT4, TYK2
38
Show member pathways
7.9TYK2, PTPN2, IL2RA, IL2RB, CSF2
39
Show member pathways
7.5PTPN2, PTPN22, TGFB1, IL2RA, IL2RB, CSF2
40
Show member pathways
7.5TYK2, TGFB1, FAS, IL2RA, IL2RB, CSF2

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1lentinan4510.3IL2RB, IL2RA
2mycophenolate4510.3IL2RB, IL2RA
3thymoglobulin4510.2IL2RB, IL2RA
4denileukin diftitox45 51 1112.1IL2RB, IL2RA
5delta9-tetrahydrocannabinol459.9IL2RB, IL2RA
6basiliximab45 1110.9IL2RA, IL2RB
7infliximab45 51 1111.8FAS, IL2RA, IL2RB
8erythromycin45 3 51 1112.7IL2RA, TGFB1, IL2RB
9prednisolone45 29 1111.6FAS, IL2RA, IL2RB
10daclizumab45 1110.6IL2RA, IL2RB
11verapamil45 29 51 24 1113.5TGFB1, IL2RB, IL2RA
12pentoxifylline45 1110.4CSF2, IL2RB, IL2RA
13neopterin459.4IL2RB, CSF2, IL2RA
14methacholine45 51 1111.2TGFB1, CSF2, IL2RB
15rituximab45 51 1111.1CSF2, IL2RA, TGFB1
16bleomycin45 1110.1CSF2, IL2RA, TGFB1
17phosphotyrosine459.1TYK2, PTPN2, STAT4, IL2RB
181,25 dihydroxy vitamin d3459.1IL2RB, CSF2, TGFB1
19okt3459.1IL2RA, FAS, CSF2, IL2RB
20ivig459.1CSF2, IL2RB, IL2RA, FAS
21daunorubicin45 51 1111.0TGFB1, FAS, CSF2
22creatinine459.0FAS, IL2RA, IL2RB, TGFB1
23ionomycin459.0IL2RA, IL2RB, CSF2, FAS
24il 10459.0IL2RB, CSF2, IL2RA, TGFB1
25nifedipine45 29 51 1111.9TGFB1, CSF2, IL2RB, IL2RA
26herbimycin a45 619.9IL2RA, CSF2, FAS
27genistein45 29 61 3 24 1113.9IL2RA, CSF2, FAS, IL2RB
28histamine45 29 2410.8TGFB1, CSF2, IL2RB, IL2RA
29etoposide45 51 61 1111.8CSF2, IL2RA, FAS, TGFB1
30tamoxifen45 51 29 1111.8CSF2, IL2RB, FAS, TGFB1
31vitamin d458.8TGFB1, FAS, CSF2, IL2RA
32pge2458.7CSF2, IL2RA, IL2RB, TGFB1
33gp 130458.7IL2RA, FAS, TYK2, CSF2
34doxorubicin45 51 1110.7TGFB1, FAS, IL2RA, CSF2
35lactate458.6CSF2, FAS, IL2RB, TGFB1
36arginine458.6PTPN22, PTPN2, CD247, IL2RB, FAS, IL2RA
37aspirin45 51 29 2411.5CSF2, IL2RA, FAS, TGFB1, IL2RB
38rantes458.5FAS, TGFB1, IL2RA, IL2RB, CSF2
39polysaccharide458.5TGFB1, FAS, IL2RB, IL2RA, CSF2
40cyclosporin a45 29 6110.5FAS, IL2RA, CSF2, IL2RB, TGFB1
41thymidine45 249.5IL2RB, TGFB1, FAS, IL2RA, CSF2
42cisplatin45 51 61 1111.5CSF2, IL2RA, TGFB1, FAS, IL2RB
43vegf458.5IL2RB, IL2RA, FAS, TGFB1, CSF2
44ifn-alpha458.5CSF2, IL2RB, IL2RA, TYK2, FAS
45cycloheximide458.3FAS, CSF2, TGFB1, IL2RB
46dexamethasone45 51 29 1111.2IL2RA, TGFB1, CSF2, STAT4, IL2RB, FAS
47serine458.1FAS, STAT4, IL2RB, TYK2, PTPN2, TGFB1
48retinoic acid45 249.1CSF2, IL2RB, TGFB1, TYK2, FAS
49phosphatidylinositol457.8TYK2, IL2RB, CD247, CSF2, IL2RA, STAT4
50tyrosine456.8PTPN22, TYK2, PTPN2, FAS, STAT4, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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16Gene Ontology
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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL2RB, IL2RA, FAS
2plasma membraneGO:0058868.1CD247, IL2RB, IL2RA, FAS, TGFB1, PTPN2

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:0069249.9FAS, IL2RA
2negative regulation of immune responseGO:0507779.8IL2RA, TGFB1
3negative regulation of T cell receptor signaling pathwayGO:0508609.6PTPN22, PTPN2
4negative regulation of T cell proliferationGO:0421309.5IL2RA, TGFB1
5T cell differentiationGO:0302179.5PTPN22, PTPN2
6extrinsic apoptotic signaling pathwayGO:0971919.2TGFB1, FAS
7myeloid dendritic cell differentiationGO:0430119.2TGFB1, CSF2
8protein phosphorylationGO:0064689.0STAT4, TGFB1, TYK2
9cytokine-mediated signaling pathwayGO:0192218.9IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2kinase bindingGO:0199009.6FAS, PTPN22
3interleukin-2 bindingGO:0199769.6IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Oligoarticular Juvenile Arthritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet