MCID: OLG015
MIFTS: 39

Oligoarticular Juvenile Arthritis malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Oligoarticular Juvenile Arthritis

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MalaCards based summary: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to arthritis and pauciarticular chronic arthritis, and has symptoms including joint swelling, arthralgia and autoimmunity. An important gene associated with Oligoarticular Juvenile Arthritis is CD247 (CD247 molecule), and among its related pathways are Inflammatory Response Pathway and IL2 signaling events mediated by PI3K. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Oligoarticular Juvenile Arthritis, Aliases & Descriptions:

Name: Oligoarticular Juvenile Arthritis 47
Juvenile Pauciarticular Chronic Arthritis 60
 
Pauciarticular Chronic Arthritis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

47
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet47 85410
ICD10 via Orphanet26 M08.4

Related Diseases for Oligoarticular Juvenile Arthritis

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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4PTPN22, TGFB1, IL2RB, CSF2
2pauciarticular chronic arthritis10.6
3oligoarticular juvenile arthritis with anti-nuclear antibodies10.5
4oligoarticular juvenile arthritis without anti-nuclear antibodies10.5
5uveitis10.5IL2RA
6t-cell large granular lymphocyte leukemia10.4IL2RB, CSF2
7posterior uveitis10.3IL2RB, IL2RA
8pancytopenia10.3IL2RA, CSF2
9hypereosinophilic syndrome10.3IL2RA, CSF2
10thyroiditis10.3PTPN22
11tropical spastic paraparesis10.3IL2RB, IL2RA
12extrinsic allergic alveolitis10.3IL2RB, IL2RA
13acute graft versus host disease10.3IL2RB, IL2RA
14severe combined immunodeficiency, x-linked10.3IL2RA, IL2RB
15adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3IL2RB, IL2RA
16common variable immunodeficiency10.3IL2RB, IL2RA
17hcl-v10.3IL2RB, IL2RA
18vogt-koyanagi-harada disease10.3IL2RA, FAS
19peripheral t-cell lymphoma10.3IL2RB, IL2RA
20juvenile rheumatoid arthritis10.3IL2RA, IL2RB
21skin disease10.3IL2RA, TGFB1
22pulmonary tuberculosis10.3IL2RA, CD247
23autoimmune lymphoproliferative syndrome10.2IL2RA, FAS
24pneumonia10.2TGFB1, IL2RB, CSF2
25splenomegaly10.2FAS, IL2RA
26pulmonary sarcoidosis10.2CSF2, IL2RB, IL2RA
27keloids10.2FAS, TGFB1
28hepatitis b10.2TGFB1, IL2RA
29diphtheria10.2IL2RA, IL2RB, CSF2
30mycosis fungoides10.2IL2RA, IL2RB
31eosinophilia10.2CSF2, IL2RB, IL2RA
32allergic asthma10.2CSF2, IL2RB, IL2RA
33atopic dermatitis10.2IL2RA, IL2RB, CSF2
34aplastic anemia10.2FAS, CSF2
35anaplastic large cell lymphoma10.2IL2RB, IL2RA
36sezary's disease10.2IL2RB, IL2RA, STAT4
37lupus nephritis10.2IL2RA, TGFB1
38hepatitis10.1IL2RB, FAS, TGFB1
39cutaneous t cell lymphoma10.1FAS, IL2RA, IL2RB
40myeloid leukemia10.1TGFB1, FAS, CSF2
41severe combined immunodeficiency10.1TYK2, IL2RA, IL2RB
42monocytic leukemia10.1CSF2, FAS
43chronic lymphocytic leukemia10.1IL2RB, IL2RA, FAS
44connective tissue disease10.1PTPN22, TGFB1, IL2RA
45hodgkin lymphoma10.1IL2RA, IL2RB, CSF2, CD247
46t-cell leukemia10.1IL2RB, IL2RA, FAS
47hypersensitivity reaction type ii disease10.1PTPN22, TGFB1, IL2RA
48asthma10.0CSF2, IL2RA, STAT4, TGFB1
49graft-versus-host disease, protection against10.0FAS, IL2RA, IL2RB, CSF2
50ovarian cancer, somatic10.0TGFB1, FAS, CSF2, CD247

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

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Symptoms:

 47
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

HPO human phenotypes related to Oligoarticular Juvenile Arthritis:

id Description Frequency HPO Source Accession
1 joint swelling hallmark (90%) HP:0001386
2 arthralgia hallmark (90%) HP:0002829
3 autoimmunity hallmark (90%) HP:0002960
4 inflammatory abnormality of the eye typical (50%) HP:0100533

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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Drug clinical trials:

Search ClinicalTrials for Oligoarticular Juvenile Arthritis

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

31
Eye, Bone, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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Publications for Oligoarticular Juvenile Arthritis

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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2RB, IL2RA
2
Show member pathways
IL2 signaling events mediated by STAT536
9.9IL2RB, IL2RA
39.8STAT4, IL2RA
4
Show member pathways
9.5STAT4, IL2RA, IL2RB
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.5STAT4, TYK2
69.5STAT4, TYK2
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.3CSF2, IL2RA
89.3TGFB1, TYK2
99.3IL2RB, IL2RA, TGFB1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.3CD247, FAS, PTPN2
11
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2TYK2, IL2RA, IL2RB
129.2IL2RB, IL2RA, TYK2
13
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.2STAT4, IL2RA, IL2RB, CD247
14
Show member pathways
9.2TGFB1, FAS, IL2RA
159.2IL2RA, STAT4, TYK2
169.1CSF2, TGFB1
179.1CSF2, TGFB1
18
Show member pathways
9.1CSF2, TGFB1
19
Show member pathways
9.0IL2RA, TGFB1, TYK2
209.0TGFB1, STAT4, IL2RA, CD247
219.0PTPN22, FAS, IL2RA, IL2RB
22
Show member pathways
9.0STAT4, TGFB1, TYK2
23
Show member pathways
IL27-mediated signaling events36
9.0STAT4, TGFB1, TYK2
24
Show member pathways
9.0TYK2, TGFB1, STAT4
25
Show member pathways
Immune response CD16 signaling in NK cells58
9.0FAS, CSF2, CD247
26
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TGFB1, FAS, STAT4, CD247
27
Show member pathways
8.8IL2RB, IL2RA, FAS, TYK2
28
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.6CD247, IL2RB, IL2RA, STAT4, TYK2
29
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.6TYK2, STAT4, IL2RA, IL2RB, CD247
308.5TGFB1, IL2RA, IL2RB, CSF2
31
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.4CD247, CSF2, FAS, TGFB1
32
Show member pathways
8.4TYK2, IL2RA, IL2RB, CSF2
33
Show member pathways
8.4TYK2, TGFB1, STAT4, IL2RA, IL2RB
34
Show member pathways
8.2TGFB1, STAT4, IL2RA, IL2RB, CSF2
35
Show member pathways
8.2CSF2, IL2RB, IL2RA, STAT4, TGFB1
36
Show member pathways
8.1CSF2, IL2RB, IL2RA, FAS, TGFB1
37
Show member pathways
Type III interferon signaling36
8.1CSF2, IL2RB, IL2RA, STAT4, TYK2
38
Show member pathways
7.9TYK2, PTPN2, IL2RA, IL2RB, CSF2
39
Show member pathways
7.5PTPN2, PTPN22, TGFB1, IL2RA, IL2RB, CSF2
40
Show member pathways
7.5TYK2, TGFB1, FAS, IL2RA, IL2RB, CSF2

Compounds for genes affiliated with Oligoarticular Juvenile Arthritis

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Compounds related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1lentinan4310.3IL2RB, IL2RA
2mycophenolate4310.3IL2RB, IL2RA
3thymoglobulin4310.2IL2RB, IL2RA
4denileukin diftitox43 49 1212.1IL2RB, IL2RA
5delta9-tetrahydrocannabinol439.9IL2RB, IL2RA
6basiliximab43 1210.9IL2RA, IL2RB
7infliximab43 49 1211.8FAS, IL2RA, IL2RB
8erythromycin43 2 49 1212.7IL2RA, TGFB1, IL2RB
9prednisolone43 28 1211.6FAS, IL2RA, IL2RB
10daclizumab43 1210.6IL2RA, IL2RB
11verapamil43 28 49 24 1213.5TGFB1, IL2RB, IL2RA
12pentoxifylline43 1210.4CSF2, IL2RB, IL2RA
13neopterin439.4IL2RB, CSF2, IL2RA
14methacholine43 49 1211.2TGFB1, CSF2, IL2RB
15rituximab43 49 1211.1CSF2, IL2RA, TGFB1
16bleomycin43 1210.1CSF2, IL2RA, TGFB1
17phosphotyrosine439.1TYK2, PTPN2, STAT4, IL2RB
181,25 dihydroxy vitamin d3439.1IL2RB, CSF2, TGFB1
19okt3439.1IL2RA, FAS, CSF2, IL2RB
20ivig439.1CSF2, IL2RB, IL2RA, FAS
21daunorubicin43 49 1211.0TGFB1, FAS, CSF2
22creatinine439.0FAS, IL2RA, IL2RB, TGFB1
23ionomycin439.0IL2RA, IL2RB, CSF2, FAS
24il 10439.0IL2RB, CSF2, IL2RA, TGFB1
25nifedipine43 28 49 1211.9TGFB1, CSF2, IL2RB, IL2RA
26herbimycin a43 599.9IL2RA, CSF2, FAS
27genistein43 28 59 2 24 1213.9IL2RA, CSF2, FAS, IL2RB
28histamine43 28 2410.8TGFB1, CSF2, IL2RB, IL2RA
29etoposide43 49 59 1211.8CSF2, IL2RA, FAS, TGFB1
30tamoxifen43 49 28 1211.8CSF2, IL2RB, FAS, TGFB1
31vitamin d438.8TGFB1, FAS, CSF2, IL2RA
32pge2438.7CSF2, IL2RA, IL2RB, TGFB1
33gp 130438.7IL2RA, FAS, TYK2, CSF2
34doxorubicin43 49 1210.7TGFB1, FAS, IL2RA, CSF2
35lactate438.6CSF2, FAS, IL2RB, TGFB1
36arginine438.6PTPN22, PTPN2, CD247, IL2RB, FAS, IL2RA
37aspirin43 49 28 2411.5CSF2, IL2RA, FAS, TGFB1, IL2RB
38rantes438.5FAS, TGFB1, IL2RA, IL2RB, CSF2
39polysaccharide438.5TGFB1, FAS, IL2RB, IL2RA, CSF2
40cyclosporin a43 28 5910.5FAS, IL2RA, CSF2, IL2RB, TGFB1
41thymidine43 249.5IL2RB, TGFB1, FAS, IL2RA, CSF2
42cisplatin43 49 59 1211.5CSF2, IL2RA, TGFB1, FAS, IL2RB
43vegf438.5IL2RB, IL2RA, FAS, TGFB1, CSF2
44ifn-alpha438.5CSF2, IL2RB, IL2RA, TYK2, FAS
45cycloheximide438.3FAS, CSF2, TGFB1, IL2RB
46dexamethasone43 49 28 1211.2IL2RA, TGFB1, CSF2, STAT4, IL2RB, FAS
47serine438.1FAS, STAT4, IL2RB, TYK2, PTPN2, TGFB1
48retinoic acid43 249.1CSF2, IL2RB, TGFB1, TYK2, FAS
49phosphatidylinositol437.8TYK2, IL2RB, CD247, CSF2, IL2RA, STAT4
50tyrosine436.8PTPN22, TYK2, PTPN2, FAS, STAT4, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1IL2RB, IL2RA, FAS
2plasma membraneGO:00058868.1CD247, IL2RB, IL2RA, FAS, TGFB1, PTPN2

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation-induced cell death of T cellsGO:00069249.9FAS, IL2RA
2negative regulation of immune responseGO:00507779.8IL2RA, TGFB1
3negative regulation of T cell receptor signaling pathwayGO:00508609.6PTPN22, PTPN2
4negative regulation of T cell proliferationGO:00421309.5IL2RA, TGFB1
5T cell differentiationGO:00302179.5PTPN22, PTPN2
6extrinsic apoptotic signaling pathwayGO:00971919.2TGFB1, FAS
7myeloid dendritic cell differentiationGO:00430119.2TGFB1, CSF2
8protein phosphorylationGO:00064689.0STAT4, TGFB1, TYK2
9cytokine-mediated signaling pathwayGO:00192218.9IL2RB, STAT4, PTPN2, TYK2

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:00049119.8IL2RB, IL2RA
2kinase bindingGO:00199009.6FAS, PTPN22
3interleukin-2 bindingGO:00199769.6IL2RB, IL2RA

Products for genes affiliated with Oligoarticular Juvenile Arthritis

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Sources for Oligoarticular Juvenile Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet