MCID: OLG015
MIFTS: 38

Oligoarticular Juvenile Arthritis malady

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Oligoarticular Juvenile Arthritis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Oligoarticular Juvenile Arthritis:

Name: Oligoarticular Juvenile Arthritis 51
Juvenile Pauciarticular Chronic Arthritis 65
 
Pauciarticular Chronic Arthritis 51

Characteristics:

Orphanet epidemiological data:

51
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 85410
ICD10 via Orphanet28 M08.4
UMLS65 C2931171

Summaries for Oligoarticular Juvenile Arthritis

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MalaCards based summary: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to pauciarticular chronic arthritis and oligoarticular juvenile arthritis with anti-nuclear antibodies, and has symptoms including joint swelling, arthralgia and autoimmunity. An important gene associated with Oligoarticular Juvenile Arthritis is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways are Interferon type I and Jak/STAT Signaling Pathway Intracellular Regulation. Affiliated tissues include bone, eye and thyroid, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Related Diseases for Oligoarticular Juvenile Arthritis

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Graphical network of diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms for Oligoarticular Juvenile Arthritis

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Symptoms:

 51
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

HPO human phenotypes related to Oligoarticular Juvenile Arthritis:

id Description Frequency HPO Source Accession
1 joint swelling hallmark (90%) HP:0001386
2 arthralgia hallmark (90%) HP:0002829
3 autoimmunity hallmark (90%) HP:0002960
4 inflammatory abnormality of the eye typical (50%) HP:0100533

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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Drugs for Oligoarticular Juvenile Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2
Certolizumab pegolapprovedPhase 3117428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
Cimzia
D03441
3AnalgesicsPhase 39358
4Immunologic FactorsPhase 318483
5Peripheral Nervous System AgentsPhase 318510
6Gastrointestinal AgentsPhase 36401
7Immunosuppressive AgentsPhase 310422
8Anti-Inflammatory AgentsPhase 38478
9Anti-Inflammatory Agents, Non-SteroidalPhase 33549
10Analgesics, Non-NarcoticPhase 35184
11Antirheumatic AgentsPhase 38496
12Pharmaceutical SolutionsPhase 37004
13
Leflunomideapproved, investigational6275706-12-63899
Synonyms:
210165-51-8
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl
4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl)
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
75706-12-6
A77 1486
AB00052389
AC-6796
AC1L1GYK
AC1Q2EVA
AKOS000265193
AP-501/42475599
Arava
Arava (TN)
Arava, Leflunomide
Aventis Behring Brand of Leflunomide
Aventis Brand of Leflunomide
Aventis Pharma Brand of Leflunomide
BIDD:PXR0189
BPBio1_000930
BRD-K78692225-001-03-9
BSPBio_000844
C045463
C07905
CAS-75706-12-6
CHEBI:6402
CHEMBL960
CID3899
D00749
DB01097
DivK1c_000916
EU-0100649
HMS1570K06
HMS1922M06
HMS2090O12
HMS502N18
HSDB 7289
HWA 486
HWA-486
Hoechst Brand of Leflunomide
I06-2131
IDI1_000916
KBio1_000916
KBio2_000802
KBio2_003370
KBio2_005938
KBioSS_000802
L 5025
L5025_SIGMA
 
LS-86580
Leflunomid
Leflunomida
Leflunomida [INN-Spanish]
Leflunomide
Leflunomide (JAN/USAN/INN)
Leflunomide [USAN:INN]
Leflunomidum
Leflunomidum [INN-Latin]
Lefunomide
Lefunomide [INN-Spanish]
Lefunomide [Inn-Spanish]
Lopac-L-5025
Lopac0_000649
MLS-0003109.0001
MLS000069648
MLS001076267
MolPort-002-345-613
N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
NCGC00015610-01
NCGC00015610-02
NCGC00015610-03
NCGC00015610-07
NCGC00015610-12
NCGC00022625-03
NCGC00022625-04
NCGC00022625-05
NCGC00022625-06
NCGC00022625-07
NCGC00022625-08
NINDS_000916
NSC677411
Prestwick0_000772
Prestwick1_000772
Prestwick2_000772
Prestwick3_000772
Prestwick_87
RS-34821
S1247_Selleck
SMR000058209
SPBio_002783
SPECTRUM1503927
SU 101
SU 101 (pharmaceutical)
SU-101
SU101
Spectrum5_000850
Spectrum_000322
TL8005179
UNII-G162GK9U4W
ZINC00004840
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
leflunomide
lefunamide
14
Methotrexateapproved14441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
15
Folic Acidapproved, nutraceutical292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
16Folic Acid Antagonists1643
17Vitamin B Complex2847
18Nucleic Acid Synthesis Inhibitors3836
19Antibodies, Antinuclear6
20Immunoglobulins4477
21Antibodies4477
22Antimetabolites9454
23Antimetabolites, Antineoplastic5770
24Dermatologic Agents4555
25Cyclosporins873
26Vitamin B9Nutraceutical2924
27Folinic AcidNutraceutical2604
28FolateNutraceutical2924

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
2Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
3Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
4Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic ArthritisTerminatedNCT01261624Phase 2
5Biomarkers in Idiopathic Juvenile ArthritisRecruitingNCT02343770
6Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or MethotrexateRecruitingNCT01399281
7Juvenile Arthritis Quantitative ImagingRecruitingNCT02684695

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

33
Bone, Eye, Thyroid, T cells

Animal Models for Oligoarticular Juvenile Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Oligoarticular Juvenile Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1CD247, FAS, IL2RB, PTPN2, PTPN22, STAT4
2MP:00107686.6CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
3MP:00053976.6CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22
4MP:00053876.3CD247, FAS, IL2RA, IL2RB, PTPN2, PTPN22

Publications for Oligoarticular Juvenile Arthritis

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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.8STAT4, TYK2
29.3PTPN2, STAT4, TYK2
39.3IL2RA, STAT4
49.2IL2RA, IL2RB
5
Show member pathways
8.9IL2RA, STAT4, TYK2
68.9IL2RA, IL2RB, STAT4
78.8CD247, IL2RA, STAT4
8
Show member pathways
8.7CD247, IL2RA, IL2RB
9
Show member pathways
8.6FAS, IL2RA, IL2RB
108.5IL2RA, IL2RB, STAT4, TYK2
11
Show member pathways
8.3CD247, IL2RA, IL2RB, STAT4
12
Show member pathways
8.2FAS, IL2RA, IL2RB, TYK2
13
Show member pathways
8.2CD247, FAS, IL2RA, STAT4
14
Show member pathways
8.1IL2RA, IL2RB, PTPN2, STAT4, TYK2
15
Show member pathways
8.0CD247, IL2RA, IL2RB, STAT4, TYK2
16
Show member pathways
8.0CD247, IL2RA, IL2RB, STAT4, TYK2
17
Show member pathways
7.8FAS, IL2RA, IL2RB, PTPN2, PTPN22
18
Show member pathways
7.7CD247, FAS, IL2RA, IL2RB, STAT4

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1T cell differentiationGO:003021710.2PTPN2, PTPN22
2interleukin-2-mediated signaling pathwayGO:00381109.9IL2RA, IL2RB
3cytokine-mediated signaling pathwayGO:00192219.8PTPN2, STAT4, TYK2
4negative regulation of T cell receptor signaling pathwayGO:00508609.7PTPN2, PTPN22
5activation-induced cell death of T cellsGO:00069249.7FAS, IL2RA
6T cell homeostasisGO:00430299.4FAS, IL2RA
7protein complex assemblyGO:00064619.3FAS, IL2RB
8innate immune responseGO:00450878.0CD247, IL2RA, IL2RB, TYK2

Sources for Oligoarticular Juvenile Arthritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet