MCID: OLG015
MIFTS: 40

Oligoarticular Juvenile Arthritis malady

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Oligoarticular Juvenile Arthritis

About this section
Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Oligoarticular Juvenile Arthritis:

Name: Oligoarticular Juvenile Arthritis 54
Juvenile Pauciarticular Chronic Arthritis 68
 
Pauciarticular Chronic Arthritis 54

Characteristics:

Orphanet epidemiological data:

54
oligoarticular juvenile arthritis:
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA85410
ICD10 via Orphanet31 M08.4

Summaries for Oligoarticular Juvenile Arthritis

About this section
MalaCards based summary: Oligoarticular Juvenile Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to pauciarticular chronic arthritis and oligoarticular juvenile arthritis with anti-nuclear antibodies, and has symptoms including joint swelling, arthralgia and autoimmunity. An important gene associated with Oligoarticular Juvenile Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways are Jak/STAT Signaling Pathway Intracellular Regulation and OX40 Pathway. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are digestive/alimentary and cellular.

Related Diseases for Oligoarticular Juvenile Arthritis

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Diseases related to Oligoarticular Juvenile Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1pauciarticular chronic arthritis12.2
2oligoarticular juvenile arthritis with anti-nuclear antibodies12.1
3oligoarticular juvenile arthritis without anti-nuclear antibodies12.1
4basidiobolomycosis10.6CXCL8, IL10
5gonadal disease10.6CXCL8, IL10
6acute interstitial pneumonia10.6CXCL8, IL10
7predominantly cortical thymoma10.6IL10, IL6
8corneal deposit10.6CXCL8, IL6
9tarsal tunnel syndrome10.6CXCL8, IL6
10maligant granulosa cell tumor of ovary10.6CXCL8, IL6
11addison's disease10.6CXCL8, IL10
12anterior dislocation of lens10.6CXCL8, IL6
13retinal vascular disease10.6CXCL8, IL6
14angioma hereditary neurocutaneous10.6CSF2, IL6
15lymphangiectasia, intestinal10.5CSF2, CXCL8
16ethmoid sinus adenoid cystic carcinoma10.5IL10, IL6
17autosomal dominant cerebellar ataxia10.5CXCL8, IL6
18skin disease10.5CXCL8, IL6
19prostate calculus10.5CXCL8, PTPN22
20polyhydramnios10.5IL10, IL6
21subglottis neoplasm10.5CXCL8, IL6
22herpangina10.5IL10, IL6
23osteogenesis imperfecta, type x10.5CXCL8, IL6
24abdominal chemodectomas with cutaneous angiolipomas10.5IL6, PTPN22
25infancy electroclinical syndrome10.5CXCL8, IL10, IL6
26antigen-peptide-transporter 2 deficiency10.5IL6, PTPN22
27marchiafava bignami disease10.5CXCL8, IL10, IL6
28orbital lymphangioma10.5CXCL8, IL10, IL6
29accessory nerve disease10.4CXCL8, IL10, IL6
3010.4CXCL8, IL10, IL6
31kidney angiomyolipoma10.4CXCL8, IL10, IL6
32serous labyrinthitis10.4CXCL8, IL10, IL6
33blind hypotensive eye10.4CSF2, CXCL8, IL10
34intestinal variant cervical mucinous adenocarcinoma10.4CXCL8, IL10, IL6
35alopecia10.4CXCL8, IL10, IL6
36neonatal period electroclinical syndrome10.4CXCL8, IL10, IL6
37common cold10.4CXCL8, IL10, IL6
38bacteriuria10.4CXCL8, IL10, IL6
39spondylolysis10.4CXCL8, IL10, IL6
40alcohol abuse10.4CXCL8, IL10, IL6
41burn scar10.4CXCL8, IL10, IL6
42diphtheria10.4CXCL8, IL10, IL6
43lymphangioma10.4CXCL8, IL10, IL6
44acute posterior multifocal placoid pigment epitheliopathy10.4CSF2, CXCL8, IL6
45dentinogenesis imperfecta10.4CXCL8, IL10, IL6
46pleomorphic lipoma10.4CXCL8, IL10, IL6
47pasteurellosis10.4CSF2, CXCL8, IL6
48mandibular cancer10.4CXCL8, IL10, IL6
49eosinophilic gastroenteritis10.4CXCL8, IL10, IL6
50lung sarcoma10.4CXCL8, IL10, IL6

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Arthritis:



Diseases related to oligoarticular juvenile arthritis

Symptoms & Phenotypes for Oligoarticular Juvenile Arthritis

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Human phenotypes related to Oligoarticular Juvenile Arthritis:

 64 54 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint swelling64 54 hallmark (90%) Very frequent (99-80%) HP:0001386
2 arthralgia64 54 hallmark (90%) Very frequent (99-80%) HP:0002829
3 autoimmunity64 hallmark (90%) HP:0002960
4 inflammatory abnormality of the eye64 typical (50%) HP:0100533
5 iridocyclitis54 Frequent (79-30%)
6 antinuclear antibody positivity54 Very frequent (99-80%)
7 elevated erythrocyte sedimentation rate54 Very frequent (99-80%)
8 juvenile rheumatoid arthritis54 Very frequent (99-80%)
9 elevated c-reactive protein level54 Very frequent (99-80%)

MGI Mouse Phenotypes related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0FAS, IL10, IL2RA, IL6, PTPN2, PTPN22
2MP:00053847.8CD247, CSF2, FAS, IL10, IL6, PTPN2
3MP:00053787.6CSF2, FAS, IL10, IL2RA, IL2RB, IL6
4MP:00053797.6CD247, CSF2, FAS, IL10, IL2RB, IL6
5MP:00053976.9CD247, CSF2, FAS, IL10, IL2RA, IL2RB
6MP:00053876.8CD247, CSF2, FAS, IL10, IL2RA, IL2RB
7MP:00107686.1CD247, CSF2, FAS, IL10, IL2RA, IL2RB

Drugs & Therapeutics for Oligoarticular Juvenile Arthritis

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Drugs for Oligoarticular Juvenile Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etanerceptapproved, investigationalPhase 3397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2
Certolizumab pegolapprovedPhase 3122428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
3
AbataceptapprovedPhase 3192332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
4
AdalimumabapprovedPhase 3478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
5
BenzocaineapprovedPhase 318921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
6tannic acidapproved, NutraceuticalPhase 31892
7Anti-Inflammatory Agents, Non-SteroidalPhase 34295
8Anti-Inflammatory AgentsPhase 310355
9Analgesics, Non-NarcoticPhase 36260
10AnalgesicsPhase 311287
11Antirheumatic AgentsPhase 310627
12Immunosuppressive AgentsPhase 312770
13Peripheral Nervous System AgentsPhase 322776
14Gastrointestinal AgentsPhase 38109
15Pharmaceutical SolutionsPhase 37793
16Rheumatoid FactorPhase 36
17
Cyclosporineapproved, investigational, vet_approved91579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
18
Leflunomideapproved, investigational6775706-12-63899
Synonyms:
210165-51-8
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl
4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl)
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
75706-12-6
A77 1486
AB00052389
AC-6796
AC1L1GYK
AC1Q2EVA
AKOS000265193
AP-501/42475599
Arava
Arava (TN)
Arava, Leflunomide
Aventis Behring Brand of Leflunomide
Aventis Brand of Leflunomide
Aventis Pharma Brand of Leflunomide
BIDD:PXR0189
BPBio1_000930
BRD-K78692225-001-03-9
BSPBio_000844
C045463
C07905
CAS-75706-12-6
CHEBI:6402
CHEMBL960
CID3899
D00749
DB01097
DivK1c_000916
EU-0100649
HMS1570K06
HMS1922M06
HMS2090O12
HMS502N18
HSDB 7289
HWA 486
HWA-486
Hoechst Brand of Leflunomide
I06-2131
IDI1_000916
KBio1_000916
KBio2_000802
KBio2_003370
KBio2_005938
KBioSS_000802
L 5025
L5025_SIGMA
 
LS-86580
Leflunomid
Leflunomida
Leflunomida [INN-Spanish]
Leflunomide
Leflunomide (JAN/USAN/INN)
Leflunomide [USAN:INN]
Leflunomidum
Leflunomidum [INN-Latin]
Lefunomide
Lefunomide [INN-Spanish]
Lefunomide [Inn-Spanish]
Lopac-L-5025
Lopac0_000649
MLS-0003109.0001
MLS000069648
MLS001076267
MolPort-002-345-613
N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
NCGC00015610-01
NCGC00015610-02
NCGC00015610-03
NCGC00015610-07
NCGC00015610-12
NCGC00022625-03
NCGC00022625-04
NCGC00022625-05
NCGC00022625-06
NCGC00022625-07
NCGC00022625-08
NINDS_000916
NSC677411
Prestwick0_000772
Prestwick1_000772
Prestwick2_000772
Prestwick3_000772
Prestwick_87
RS-34821
S1247_Selleck
SMR000058209
SPBio_002783
SPECTRUM1503927
SU 101
SU 101 (pharmaceutical)
SU-101
SU101
Spectrum5_000850
Spectrum_000322
TL8005179
UNII-G162GK9U4W
ZINC00004840
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
leflunomide
lefunamide
19
Methotrexateapproved15181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
20
Folic Acidapproved, nutraceutical, vet_approved427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
21Folic Acid Antagonists2200
22Nucleic Acid Synthesis Inhibitors4855
23Vitamin B Complex4229
24Immunoglobulins6045
25Antibodies, Antinuclear6
26Antibodies6045
27Antimetabolites11774
28Antimetabolites, Antineoplastic7171
29Dermatologic Agents5674
30Vitamin B9Nutraceutical4279
31Folinic AcidNutraceutical3150
32FolateNutraceutical4279

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
2Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
3Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
4Treatment Tapering in JIA With Inactive DiseaseNot yet recruitingNCT02840175Phase 3
5Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic ArthritisTerminatedNCT01261624Phase 2
6Biomarkers in Idiopathic Juvenile ArthritisRecruitingNCT02343770
7Juvenile Arthritis Quantitative ImagingRecruitingNCT02684695
8Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or MethotrexateRecruitingNCT01399281

Search NIH Clinical Center for Oligoarticular Juvenile Arthritis

Genetic Tests for Oligoarticular Juvenile Arthritis

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Anatomical Context for Oligoarticular Juvenile Arthritis

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MalaCards organs/tissues related to Oligoarticular Juvenile Arthritis:

36
Eye, Bone, T cells

Publications for Oligoarticular Juvenile Arthritis

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Articles related to Oligoarticular Juvenile Arthritis:

idTitleAuthorsYear
1
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. (9218817)
1997

Variations for Oligoarticular Juvenile Arthritis

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Expression for genes affiliated with Oligoarticular Juvenile Arthritis

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Search GEO for disease gene expression data for Oligoarticular Juvenile Arthritis.

Pathways for genes affiliated with Oligoarticular Juvenile Arthritis

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Pathways related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathwaysScoreTop Affiliating Genes
19.6PTPN2, STAT4, TYK2
29.5CD247, IL10
3
Show member pathways
9.5IL2RA, STAT4, TYK2
49.4CD247, IL2RA, STAT4
59.3IL10, IL2RA, IL2RB
6
Show member pathways
9.3IL6, STAT4, TYK2
7
Show member pathways
9.2CD247, IL2RA, IL2RB, STAT4
89.1IL10, IL6, TYK2
99.1IL10, IL2RA, IL6
109.1FAS, IL10, IL6
11
Show member pathways
9.0CSF2, IL2RA, IL2RB
129.0IL10, IL2RA, IL2RB, STAT4
13
Show member pathways
9.0CXCL8, FAS, IL6
14
Show member pathways
8.8CD247, IL2RA, IL2RB, STAT4, TYK2
158.8CXCL8, IL10, IL6
168.8CXCL8, IL10, IL6
178.8CXCL8, IL10, IL6
18
Show member pathways
8.8IL10, IL6, STAT4, TYK2
19
Show member pathways
8.8IL10, IL6, STAT4, TYK2
208.8CSF2, IL2RA, IL6
218.8CSF2, FAS, IL6
22
Show member pathways
8.7CSF2, CXCL8, IL2RA
238.7CXCL8, IL2RA, IL6, STAT4
248.6CSF2, IL10, IL6
258.6CSF2, IL10, IL6
268.5CSF2, IL2RA, IL2RB, IL6
278.5CSF2, CXCL8, IL6
28
Show member pathways
8.5CSF2, CXCL8, IL6
298.5CSF2, CXCL8, IL6
30
Show member pathways
8.5CXCL8, IL10, IL6, TYK2
31
Show member pathways
8.3CD247, FAS, IL10, IL6, STAT4
328.2CSF2, CXCL8, IL2RB, IL6
338.2IL10, IL2RA, IL2RB, IL6, STAT4, TYK2
34
Show member pathways
8.2CXCL8, IL10, IL2RA, IL2RB, IL6
35
Show member pathways
8.1CSF2, FAS, IL10, IL2RA, IL2RB
36
Show member pathways
8.0CXCL8, FAS, IL2RA, IL2RB, IL6, TYK2
378.0CSF2, IL10, IL2RA, IL2RB, IL6
388.0CSF2, CXCL8, IL10, IL6
398.0CSF2, CXCL8, IL10, IL6
40
Show member pathways
7.8CD247, CSF2, FAS, IL10, IL6
417.8FAS, IL10, IL2RA, IL2RB, PTPN2, PTPN22
42
Show member pathways
7.7CD247, CXCL8, FAS, IL10, IL6, STAT4
43
Show member pathways
7.6CXCL8, IL10, IL2RA, IL2RB, IL6, STAT4
44
Show member pathways
6.5CSF2, CXCL8, FAS, IL10, IL2RA, IL2RB
45
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA
46
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA
47
Show member pathways
6.3CD247, CSF2, CXCL8, FAS, IL10, IL2RA

GO Terms for genes affiliated with Oligoarticular Juvenile Arthritis

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Cellular components related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0FAS, IL2RA, IL2RB, IL6

Biological processes related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:005086010.6PTPN2, PTPN22
2interleukin-2-mediated signaling pathwayGO:003811010.5IL2RA, IL2RB
3activation-induced cell death of T cellsGO:000692410.5FAS, IL2RA
4negative regulation of lipid storageGO:001088810.4IL6, PTPN2
5cellular response to hepatocyte growth factor stimulusGO:003572910.2IL10, IL6
6defense response to protozoanGO:004283210.2IL10, IL6
7positive regulation of JAK-STAT cascadeGO:004642710.1IL10, IL6
8negative regulation of inflammatory responseGO:005072810.0IL10, IL2RA, PTPN2
9cellular response to interleukin-1GO:00713479.7CXCL8, FAS, IL6
10response to glucocorticoidGO:00513849.6FAS, IL10, IL6
11response to molecule of bacterial originGO:00022379.3CXCL8, IL10
12regulation of cell proliferationGO:00421279.0CSF2, FAS, IL6, TYK2
13response to lipopolysaccharideGO:00324969.0FAS, IL10, IL6, PTPN22
14inflammatory responseGO:00069548.8CXCL8, FAS, IL10, IL2RA, IL6
15cellular response to lipopolysaccharideGO:00712228.7CSF2, CXCL8, IL10, IL6
16immune responseGO:00069558.5CSF2, CXCL8, FAS, IL10, IL2RA

Molecular functions related to Oligoarticular Juvenile Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:001997610.4IL2RA, IL2RB
2interleukin-2 receptor activityGO:000491110.4IL2RA, IL2RB
3growth factor activityGO:00080839.2CSF2, IL10, IL6
4Ras guanyl-nucleotide exchange factor activityGO:00050889.0CSF2, IL2RA, IL2RB

Sources for Oligoarticular Juvenile Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet