MCID: OLG020
MIFTS: 51

Oligoarticular Juvenile Idiopathic Arthritis

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 55 69
Juvenile Pauciarticular Chronic Arthritis 69
Pauciarticular Chronic Arthritis 55
Oligoarticular Jia 55

Characteristics:

Orphanet epidemiological data:

55
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 55 ORPHA85410
UMLS via Orphanet 70 C2931171
ICD10 via Orphanet 33 M08.4

Summaries for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to uveitis and arthritis, and has symptoms including iridocyclitis, joint swelling and arthralgia. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is IL2RA (Interleukin 2 Receptor Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vaccines and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and t cells, and related phenotypes are hematopoietic system and cellular

Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.3 CXCR3 IL2RA TNF
2 arthritis 30.0 HLA-DQB1 HLA-DRB1 MIF PTPN22 STAT4 TNF
3 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 12.3
4 oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies 12.3
5 pauciarticular chronic arthritis 12.3
6 limbic encephalitis with lgi1 antibodies 10.6 HLA-DQB1 HLA-DRB1
7 metal allergy 10.5 HLA-DQB1 HLA-DRB1
8 achalasia, familial esophageal 10.5 HLA-DQA1 HLA-DQB1
9 juvenile myasthenia gravis 10.5 HLA-DRB1 TGFB1
10 autoimmune pancreatitis 10.5 HLA-DQB1 HLA-DRB1 TNF
11 lichen sclerosus 10.5 HLA-DQB1 HLA-DRB1 TNF
12 lichen planopilaris 10.5 HLA-DQB1 HLA-DRB1
13 microscopic colitis 10.5 HLA-DQB1 HLA-DRB1 TNF
14 microscopic polyangiitis 10.4 HLA-DRB1 TNF
15 panuveitis 10.4 HLA-DQB1 HLA-DRB1 TNF
16 cytomegalovirus retinitis 10.4 CCR5 HLA-DQB1 TNF
17 geographic tongue 10.4 HLA-DQB1 HLA-DRB1 TNF
18 severe hemophilia a 10.4 HLA-DQB1 HLA-DRB1 TNF
19 focal epithelial hyperplasia 10.4 HLA-DQA1 HLA-DQB1 HLA-DRB1
20 orofacial granulomatosis 10.4 CCR5 CXCR3 TNF
21 recurrent respiratory papillomatosis 10.4 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 type ii mixed cryoglobulinemia 10.4 HLA-DQB1 HLA-DRB1
23 rheumatoid vasculitis 10.4 HLA-DRB1 MIF TNF
24 acute disseminated encephalomyelitis 10.4 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 optic neuritis 10.4 CCR5 HLA-DRB1 TNF
26 idiopathic bronchiectasis 10.4 HLA-DQA1 HLA-DQB1 HLA-DRB1
27 idiopathic inflammatory myopathy 10.4 HLA-DQB1 HLA-DRB1
28 sympathetic ophthalmia 10.4 HLA-DQA1 HLA-DRB1 TNF
29 endometritis 10.4 HLA-DQA1 HLA-DQB1 TNF
30 rubella 10.4 HLA-DPB1 HLA-DRB1 TNF
31 pustulosis palmaris et plantaris 10.3 CXCR3 TGFB1 TNF
32 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1 TGFB1
33 takayasu arteritis 10.3 HLA-DPB1 HLA-DRB1 TNF
34 chronic beryllium disease 10.3 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
35 intermediate uveitis 10.3 CXCR3 IL2RA TNF
36 graft-versus-host disease 10.3 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
37 berylliosis 10.2 HLA-DPB1 HLA-DRB1
38 chagas disease 10.2 CCR5 TGFB1 TNF
39 toxoplasmosis 10.2 CCR5 HLA-DQA1 HLA-DQB1 TNF
40 rheumatic disease 10.2 HLA-DRB1 IL2RA TNF
41 ocular cicatricial pemphigoid 10.2 HLA-DQB1 HLA-DRB1 MIF TGFB1
42 neonatal lupus erythematosus 10.2 HLA-DPB1 HLA-DQA1
43 rheumatoid arthritis, systemic juvenile 10.2 HLA-DRB1 IL2RB MIF
44 acquired immunodeficiency syndrome 10.2 CCR5 IL2RA TNF
45 rheumatic heart disease 10.2 HLA-DQA1 HLA-DRB1 TGFB1 TNF
46 pulmonary sarcoidosis 10.2 CCR5 CXCR3 IL2RA TNF
47 autoimmune addison disease 10.2 HLA-DRB1 PTPN22
48 leishmaniasis 10.2 HLA-DQA1 HLA-DRB1 TGFB1 TNF
49 palindromic rheumatism 10.2 HLA-DRB1 PTPN22 TNF
50 idiopathic neutropenia 10.2 HLA-DRB1 IL2RA TGFB1 TNF

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

55 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 iridocyclitis 55 31 frequent (33%) Frequent (79-30%) HP:0001094
2 joint swelling 55 31 hallmark (90%) Very frequent (99-80%) HP:0001386
3 arthralgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002829
4 antinuclear antibody positivity 55 31 hallmark (90%) Very frequent (99-80%) HP:0003493
5 elevated erythrocyte sedimentation rate 55 31 hallmark (90%) Very frequent (99-80%) HP:0003565
6 juvenile rheumatoid arthritis 55 31 hallmark (90%) Very frequent (99-80%) HP:0005681
7 elevated c-reactive protein level 55 31 hallmark (90%) Very frequent (99-80%) HP:0011227

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQA1
2 cellular MP:0005384 10.26 BMP4 CCR5 CD247 CXCR2 CXCR3 HLA-DQB1
3 immune system MP:0005387 10.22 CXCR3 HLA-DQA1 HLA-DQB1 IL2RA IL2RB MIF
4 endocrine/exocrine gland MP:0005379 10.21 BMP4 CD247 CXCR2 HLA-DQA1 HLA-DQB1 IL2RA
5 homeostasis/metabolism MP:0005376 10.18 TNF TYK2 BMP4 CCR5 CXCR2 CXCR3
6 digestive/alimentary MP:0005381 10.06 BMP4 CCR5 HLA-DQB1 IL2RA PTPN2 PTPN22
7 mortality/aging MP:0010768 10 CXCR3 HLA-DQB1 IL2RA IL2RB PTPN2 PTPN22
8 liver/biliary system MP:0005370 9.86 TGFB1 TNF BMP4 CCR5 CXCR2 HLA-DQB1
9 renal/urinary system MP:0005367 9.5 BMP4 CXCR2 CXCR3 HLA-DQB1 PTPN22 STAT4
10 respiratory system MP:0005388 9.23 BMP4 CXCR2 CXCR3 HLA-DQB1 IL2RA PTPN22

Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

Drugs for Oligoarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunoglobulins Phase 4
3 Antibodies Phase 4
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5 Analgesics Phase 3
6 Gastrointestinal Agents Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Immunosuppressive Agents Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12 Antirheumatic Agents Phase 3
13 Antibodies, Antinuclear

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
2 Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed NCT00962741 Phase 3 Etanercept
3 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Active, not recruiting NCT01421069 Phase 3 etanercept
4 Biomarkers in Idiopathic Juvenile Arthritis Unknown status NCT02343770
5 Juvenile Arthritis Quantitative Imaging Recruiting NCT02684695

Search NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

38
Bone, Eye, T Cells, B Cells

Publications for Oligoarticular Juvenile Idiopathic Arthritis

Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show all 28)
# Title Authors Year
1
The DNA methylation landscape of CD4<sup>+</sup>T cells in oligoarticular juvenile idiopathic arthritis. ( 28969936 )
2018
2
Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. ( 28086918 )
2017
3
Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship? ( 28052441 )
2017
4
Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis. ( 29025853 )
2017
5
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial. ( 28162781 )
2017
6
The role of transforming growth factor I^ signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor I^ signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. ( 24782191 )
2014
7
Serum TNF-I+ levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. ( 24839823 )
2014
8
Re: oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24894793 )
2014
9
Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis. ( 24131380 )
2013
10
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. ( 23696632 )
2013
11
Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register. ( 23267169 )
2013
12
The role of TGFI^ signaling in fibroblast-like synoviocytes from oligoarticular juvenile idiopathic arthritis. ( 24375380 )
2013
13
Oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24413854 )
2013
14
Analysis of the classical, alternative, and mannose binding lectin pathway of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis. ( 21647665 )
2012
15
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. ( 21707991 )
2011
16
Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. ( 21813070 )
2011
17
Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation. ( 21621220 )
2011
18
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. ( 21385553 )
2011
19
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. ( 21962036 )
2011
20
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. ( 19933594 )
2010
21
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. ( 20127724 )
2010
22
Oligoclonal expansion of T cells in persistent oligoarticular juvenile idiopathic arthritis. ( 20659414 )
2010
23
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study. ( 20403210 )
2010
24
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. ( 20352219 )
2010
25
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. ( 19804628 )
2009
26
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. ( 18078632 )
2007
27
The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. ( 15703957 )
2006
28
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. ( 11371669 )
2001

Variations for Oligoarticular Juvenile Idiopathic Arthritis

Expression for Oligoarticular Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.

Pathways for Oligoarticular Juvenile Idiopathic Arthritis

Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CCR5 CD247 CXCR2 HLA-DPB1 HLA-DQA1 HLA-DQB1
2
Show member pathways
13.87 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
3
Show member pathways
13.7 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
4
Show member pathways
13.41 BMP4 CCR5 CCR8 CD247 CXCR2 CXCR3
5
Show member pathways
13.35 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
6
Show member pathways
13.28 BMP4 CCR5 CCR8 CXCR2 CXCR3 IL2RA
7
Show member pathways
13.23 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB STAT4
8
Show member pathways
12.9 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
9 12.83 BMP4 IL2RA IL2RB STAT4 TGFB1
10
Show member pathways
12.83 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
11
Show member pathways
12.71 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
12
Show member pathways
12.64 CCR5 CCR8 STAT4 TGFB1 TNF TYK2
13 12.62 IL2RA IL2RB PTPN2 PTPN22 STAT4 TNF
14
Show member pathways
12.61 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN2 TYK2
15
Show member pathways
12.47 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
16
Show member pathways
12.43 IL2RA IL2RB PTPN2 STAT4 TYK2
17
Show member pathways
12.42 CCR5 CD247 TGFB1 TNF
18
Show member pathways
12.42 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
19 12.39 CCR5 CXCR2 IL2RA IL2RB
20 12.36 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TYK2
21 12.31 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
22
Show member pathways
12.28 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 12.27 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA IL2RB
24 12.17 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 12.15 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
26 12.1 BMP4 MIF TGFB1 TNF
27
Show member pathways
12.04 CCR5 CCR8 CXCR2 CXCR3
28 12 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
29
Show member pathways
11.99 STAT4 TGFB1 TNF TYK2
30 11.98 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
31
Show member pathways
11.97 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
32 11.93 CCR5 IL2RA IL2RB STAT4 TYK2
33 11.9 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA TNF
34
Show member pathways
11.9 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
35 11.86 CXCR3 IL2RA IL2RB TNF
36
Show member pathways
11.85 STAT4 TGFB1 TYK2
37
Show member pathways
11.83 CCR5 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1
38 11.81 BMP4 TGFB1 TNF
39 11.8 CD247 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
40 11.8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 TGFB1 TNF
41
Show member pathways
11.76 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
42
Show member pathways
11.75 CCR5 CD247 HLA-DRB1 IL2RA IL2RB STAT4
43 11.7 IL2RA TGFB1 TNF
44
Show member pathways
11.69 CD247 IL2RA IL2RB STAT4 TNF
45 11.68 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
46 11.64 BMP4 TGFB1 TNF
47 11.56 CCR5 TNF TYK2
48 11.53 IL2RA IL2RB STAT4
49
Show member pathways
11.47 IL2RA IL2RB TGFB1 TNF
50 11.46 PTPN2 STAT4 TYK2

GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 9.8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 external side of plasma membrane GO:0009897 9.8 CCR5 CXCR3 HLA-DRB1 IL2RA IL2RB TNF
3 trans-Golgi network membrane GO:0032588 9.76 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.73 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 ER to Golgi transport vesicle membrane GO:0012507 9.71 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 transport vesicle membrane GO:0030658 9.67 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.46 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 cell surface GO:0009986 9.28 CCR5 CXCR2 CXCR3 HLA-DPB1 HLA-DRB1 IL2RA
10 MHC class II protein complex GO:0042613 9.26 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 plasma membrane GO:0005886 10.32 CCR5 CCR8 CD247 CXCR2 CXCR3 HLA-DPB1

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.98 MIF TGFB1 TNF TYK2
2 immune system process GO:0002376 9.98 CD247 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA MIF
3 MAPK cascade GO:0000165 9.95 CCR5 IL2RA IL2RB TGFB1 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.94 BMP4 MIF TGFB1 TNF
5 chemotaxis GO:0006935 9.93 CCR5 CCR8 CXCR2 CXCR3
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 CCR5 CCR8 CXCR2 CXCR3
7 negative regulation of gene expression GO:0010629 9.91 BMP4 MIF PTPN22 TGFB1 TNF
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 BMP4 MIF PTPN22 TGFB1 TNF
9 cell surface receptor signaling pathway GO:0007166 9.88 CCR5 CD247 CXCR2 CXCR3 IL2RA MIF
10 inflammatory response GO:0006954 9.87 CCR5 CXCR2 CXCR3 IL2RA MIF TGFB1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 MIF TGFB1 TNF
12 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.84 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 positive regulation of MAP kinase activity GO:0043406 9.83 MIF TGFB1 TNF
14 interleukin-12-mediated signaling pathway GO:0035722 9.83 MIF STAT4 TYK2
15 T cell differentiation GO:0030217 9.79 PTPN2 PTPN22 TGFB1
16 negative regulation of T cell proliferation GO:0042130 9.78 HLA-DRB1 IL2RA TGFB1
17 chemokine-mediated signaling pathway GO:0070098 9.78 CCR5 CCR8 CXCR2 CXCR3
18 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 immune response GO:0006955 9.76 CCR5 CCR8 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 PTPN22 TGFB1 TNF
21 negative regulation of myoblast differentiation GO:0045662 9.7 BMP4 TGFB1 TNF
22 negative regulation of T cell activation GO:0050868 9.69 PTPN22 TGFB1
23 negative regulation of immune response GO:0050777 9.69 IL2RA TGFB1
24 regulation of regulatory T cell differentiation GO:0045589 9.69 IL2RA TGFB1
25 positive regulation of SMAD protein import into nucleus GO:0060391 9.68 BMP4 TGFB1
26 inflammatory response to antigenic stimulus GO:0002437 9.68 HLA-DRB1 IL2RA
27 response to cholesterol GO:0070723 9.67 CCR5 TGFB1
28 positive regulation of vascular permeability GO:0043117 9.67 CXCR2 TGFB1
29 negative regulation of lipid storage GO:0010888 9.67 PTPN2 TNF
30 antigen processing and presentation GO:0019882 9.67 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
31 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.66 BMP4 TGFB1
32 regulation of protein import into nucleus GO:0042306 9.65 BMP4 TGFB1
33 common-partner SMAD protein phosphorylation GO:0007182 9.65 BMP4 TGFB1
34 T cell costimulation GO:0031295 9.65 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
35 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.64 MIF TNF
36 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.63 HLA-DQB1 HLA-DRB1
37 interleukin-2-mediated signaling pathway GO:0038110 9.62 IL2RA IL2RB
38 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.6 HLA-DQB1 HLA-DRB1
39 regulation of leukocyte migration GO:0002685 9.59 CXCR3 PTPN22
40 positive regulation of mononuclear cell migration GO:0071677 9.58 TGFB1 TNF
41 regulation of cartilage development GO:0061035 9.58 BMP4 TGFB1
42 regulation of pri-miRNA transcription by RNA polymerase II GO:1902893 9.57 BMP4 TGFB1
43 T cell receptor signaling pathway GO:0050852 9.43 CD247 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
44 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.92 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 BMP4 MIF TGFB1 TNF
2 protein tyrosine kinase binding GO:1990782 9.46 CD247 PTPN22
3 C-C chemokine receptor activity GO:0016493 9.43 CCR5 CCR8
4 C-X-C chemokine receptor activity GO:0016494 9.37 CXCR2 CXCR3
5 MHC class II receptor activity GO:0032395 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 interleukin-2 receptor activity GO:0004911 9.32 IL2RA IL2RB
7 interleukin-2 binding GO:0019976 9.26 IL2RA IL2RB
8 peptide antigen binding GO:0042605 9.26 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 chemokine receptor activity GO:0004950 8.92 CCR5 CCR8 CXCR2 CXCR3

Sources for Oligoarticular Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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