MCID: OLG020
MIFTS: 43

Oligoarticular Juvenile Idiopathic Arthritis malady

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Oligoarticular Juvenile Idiopathic Arthritis

Aliases & Descriptions for Oligoarticular Juvenile Idiopathic Arthritis:

Name: Oligoarticular Juvenile Idiopathic Arthritis 56 69
Juvenile Pauciarticular Chronic Arthritis 69
Pauciarticular Chronic Arthritis 56
Oligoarticular Jia 56

Characteristics:

Orphanet epidemiological data:

56
oligoarticular juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA85410
ICD10 via Orphanet 34 M08.4

Summaries for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards based summary : Oligoarticular Juvenile Idiopathic Arthritis, also known as juvenile pauciarticular chronic arthritis, is related to oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies and oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies, and has symptoms including iridocyclitis, joint swelling and arthralgia. An important gene associated with Oligoarticular Juvenile Idiopathic Arthritis is IL2RA (Interleukin 2 Receptor Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vaccines and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and b cells, and related phenotypes are hematopoietic system and cellular

Related Diseases for Oligoarticular Juvenile Idiopathic Arthritis

Diseases related to Oligoarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 12.2
2 oligoarticular juvenile idiopathic arthritis without anti-nuclear antibodies 12.2
3 pauciarticular chronic arthritis 12.2
4 arthritis 10.5
5 bilateral parasagittal parieto-occipital polymicrogyria 10.3 HLA-DQB1 TNF
6 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 TNF
7 midline interhemispheric variant of holoprosencephaly 10.2 FAS HLA-DQB1
8 distal trisomy 14q 10.2 HLA-DQB1 TNF
9 twin-to-twin transfusion syndrome 10.2 FAS TNF
10 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 CCR5 HLA-DQB1 TNF
11 amyotrophic lateral sclerosis type 5 10.2 IL2RA TNF
12 osteodysplasty precocious of danks mayne and kozlowski 10.2 CCR5 CXCR3 TNF
13 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL2RA TNF
14 anterior foramen magnum meningioma 10.1 CCR5 IL2RA TNF
15 cyclosporiasis 10.1 CXCR3 IL2RA TNF
16 deafness, autosomal recessive 67 10.1 CXCR3 IL2RA TNF
17 esophageal candidiasis 10.1 CXCR3 IL2RA TNF
18 small non-cleaved cell lymphoma 10.1 CD247 TNF
19 aortic coarctation 10.1 IL2RA PTPN22 TNF
20 retinal ischemia 10.1 CCR5 CXCR3 IL2RA TNF
21 periodontosis 10.1 IL2RA PTPN22 TNF
22 prostatic urethral cancer 10.0 FAS IL2RA PTPN22
23 primary polycythemia 10.0 CCR5 PTPN2
24 diabetes mellitus, insulin-dependent, 12 10.0 FAS IL2RA PTPN22
25 macrogyria, pseudobulbar palsy and mental retardation 10.0 FAS TYK2
26 advanced sleep phase syndrome, familial, 1 10.0 CCR5 CXCR3 HLA-DQB1 IL2RA TNF
27 anterior corneal pigmentation 9.9 FAS HLA-DQB1 IL2RA PTPN22
28 uveitis 9.9
29 synovitis 9.9
30 epidermolysis bullosa 9.9
31 psoriatic arthritis 9.9
32 intracranial hemorrhage in brain cerebrovascular malformations 9.9 IL2RA IL2RB PTPN22 TNF
33 inflammatory bowel disease 3 9.8 HLA-DQB1 PTPN22 TNF
34 diabetes mellitus, insulin-dependent, 20 9.8 CCR5 HLA-DQB1 IL2RA PTPN22 TNF
35 major depressive disorder and accelerated response to antidepressant drug treatment 9.8 CCR5 PTPN22 STAT4 TNF
36 hereditary ataxia 9.7 FAS IL2RA IL2RB TNF TYK2
37 articulation disorder 9.7 FAS PTPN22 STAT4 TNF
38 goodpasture syndrome 9.7 CCR5 FAS IL2RA STAT4 TNF
39 rheumatoid arthritis 9.5 HLA-DQB1 IL2RA IL2RB PTPN22 STAT4 TNF
40 cousin syndrome 9.4 CD247 CXCR3 HLA-DQB1 IL2RA PTPN22 STAT4
41 polyomavirus allograft nephropathy 8.8 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2
42 non-amyloid monoclonal immunoglobulin deposition disease 8.8 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2
43 t-cell prolymphocytic leukemia 8.3 ANKRD55 BMP4 CCR5 CD247 CXCR3 FAS

Graphical network of the top 20 diseases related to Oligoarticular Juvenile Idiopathic Arthritis:



Diseases related to Oligoarticular Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Oligoarticular Juvenile Idiopathic Arthritis

Human phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

56 32 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 iridocyclitis 56 32 Frequent (79-30%) HP:0001094
2 joint swelling 56 32 Very frequent (99-80%) HP:0001386
3 arthralgia 56 32 Very frequent (99-80%) HP:0002829
4 antinuclear antibody positivity 56 32 Very frequent (99-80%) HP:0003493
5 elevated erythrocyte sedimentation rate 56 32 Very frequent (99-80%) HP:0003565
6 juvenile rheumatoid arthritis 56 32 Very frequent (99-80%) HP:0005681
7 elevated c-reactive protein level 56 32 Very frequent (99-80%) HP:0011227

MGI Mouse Phenotypes related to Oligoarticular Juvenile Idiopathic Arthritis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 TNF PTPN2 TYK2 PTPN22 IL2RA STAT4
2 cellular MP:0005384 10.21 TNF PTPN2 TYK2 PTPN22 FAS CCR5
3 endocrine/exocrine gland MP:0005379 10.18 IL2RB TNF PTPN2 PTPN22 IL2RA STAT4
4 immune system MP:0005387 10.15 TNF PTPN2 TYK2 PTPN22 IL2RA STAT4
5 homeostasis/metabolism MP:0005376 10.14 STAT4 TNF PTPN2 TYK2 PTPN22 IL2RA
6 growth/size/body region MP:0005378 10.11 IL2RB TNF PTPN2 PTPN22 IL2RA BMP4
7 digestive/alimentary MP:0005381 10.1 TNF PTPN2 PTPN22 IL2RA CCR5 HLA-DQB1
8 mortality/aging MP:0010768 10.07 IL2RB TNF PTPN2 TYK2 PTPN22 IL2RA
9 liver/biliary system MP:0005370 9.87 IL2RB TNF PTPN22 CCR5 HLA-DQB1 BMP4
10 renal/urinary system MP:0005367 9.63 STAT4 PTPN22 FAS HLA-DQB1 CXCR3 BMP4
11 reproductive system MP:0005389 9.5 IL2RB TNF BMP4 FAS CCR5 CD247
12 respiratory system MP:0005388 9.17 TNF PTPN22 IL2RA FAS HLA-DQB1 CXCR3

Drugs & Therapeutics for Oligoarticular Juvenile Idiopathic Arthritis

Drugs for Oligoarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunoglobulins Phase 4
3 Antibodies Phase 4
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5
Adalimumab Approved Phase 3 331731-18-1 16219006
6
Abatacept Approved Phase 3 332348-12-6 10237
7
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
8
Certolizumab pegol Approved Phase 3 428863-50-7
9 tannic acid Approved, Nutraceutical Phase 3
10 Analgesics Phase 3
11 Gastrointestinal Agents Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Peripheral Nervous System Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 3
17 Antirheumatic Agents Phase 3
18 Rheumatoid Factor Phase 3
19 Pharmaceutical Solutions Phase 3
20
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
21
Methotrexate Approved 1959-05-2, 59-05-2 126941
22
Leflunomide Approved, Investigational 75706-12-6 3899
23
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
24
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
25 Folic Acid Antagonists
26 Nucleic Acid Synthesis Inhibitors
27 Dermatologic Agents
28 Vitamin B Complex
29 Antimetabolites
30 Antimetabolites, Antineoplastic
31 Antibodies, Antinuclear
32 Folate Nutraceutical
33 Vitamin B9 Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
2 Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed NCT00962741 Phase 3
3 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3
4 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Active, not recruiting NCT01421069 Phase 3
5 Pediatric Arthritis Study of Certolizumab Pegol Active, not recruiting NCT01550003 Phase 3
6 Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic Arthritis Terminated NCT01261624 Phase 2
7 Biomarkers in Idiopathic Juvenile Arthritis Recruiting NCT02343770
8 Juvenile Arthritis Quantitative Imaging Recruiting NCT02684695
9 Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or Methotrexate Recruiting NCT01399281

Search NIH Clinical Center for Oligoarticular Juvenile Idiopathic Arthritis

Genetic Tests for Oligoarticular Juvenile Idiopathic Arthritis

Anatomical Context for Oligoarticular Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Oligoarticular Juvenile Idiopathic Arthritis:

39
Bone, Eye, B Cells

Publications for Oligoarticular Juvenile Idiopathic Arthritis

Articles related to Oligoarticular Juvenile Idiopathic Arthritis:

(show all 12)
id Title Authors Year
1
Serum TNF-I+ levels and indicators of disease activity in children with oligoarticular juvenile idiopathic arthritis (oJIA) in the first year of the disease. ( 24839823 )
2014
2
The role of transforming growth factor I^ signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor I^ signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. ( 24782191 )
2014
3
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. ( 23696632 )
2013
4
Oligoarticular juvenile idiopathic arthritis among Saudi children. ( 24413854 )
2013
5
The role of TGFI^ signaling in fibroblast-like synoviocytes from oligoarticular juvenile idiopathic arthritis. ( 24375380 )
2013
6
Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis. ( 24131380 )
2013
7
An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned. ( 21707991 )
2011
8
The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. ( 19933594 )
2010
9
Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. ( 19804628 )
2009
10
Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids. ( 18078632 )
2007
11
The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. ( 15703957 )
2006
12
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. ( 11371669 )
2001

Variations for Oligoarticular Juvenile Idiopathic Arthritis

Expression for Oligoarticular Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Oligoarticular Juvenile Idiopathic Arthritis.

Pathways for Oligoarticular Juvenile Idiopathic Arthritis

Pathways related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CCR5 CD247 HLA-DQB1 IL2RA IL2RB PTPN2
2
Show member pathways
13.73 BMP4 CCR5 CD247 CXCR3 FAS IL2RA
3
Show member pathways
13.51 BMP4 CCR5 CD247 CXCR3 FAS IL2RA
4
Show member pathways
13.25 CCR5 HLA-DQB1 IL2RA IL2RB PTPN2 TNF
5
Show member pathways
13.2 BMP4 CCR5 CD247 CXCR3 FAS IL2RA
6
Show member pathways
13.04 BMP4 CCR5 CXCR3 FAS IL2RA IL2RB
7
Show member pathways
12.78 CCR5 CD247 FAS PTPN2 TNF
8
Show member pathways
12.74 CD247 FAS HLA-DQB1 IL2RA TNF
9
Show member pathways
12.68 FAS HLA-DQB1 IL2RA IL2RB TNF TYK2
10
Show member pathways
12.52 CD247 HLA-DQB1 IL2RA TNF
11
Show member pathways
12.35 CCR5 CD247 FAS TNF
12 12.34 HLA-DQB1 IL2RA IL2RB TNF
13
Show member pathways
12.34 CD247 HLA-DQB1 IL2RA IL2RB STAT4 TNF
14
Show member pathways
12.3 CD247 HLA-DQB1 IL2RA IL2RB
15
Show member pathways
12.16 CCR5 HLA-DQB1 TNF TYK2
16
Show member pathways
12.07 IL2RA IL2RB PTPN2 STAT4 TYK2
17 11.99 CCR5 IL2RA IL2RB
18 11.95 BMP4 FAS TNF
19 11.89 IL2RA IL2RB TNF
20
Show member pathways
11.86 CD247 HLA-DQB1 PTPN22
21
Show member pathways
11.85 STAT4 TNF TYK2
22 11.8 HLA-DQB1 IL2RA TNF
23 11.74 CCR5 IL2RA IL2RB STAT4
24 11.72 FAS IL2RA IL2RB PTPN2 PTPN22 STAT4
25 11.68 CXCR3 IL2RA IL2RB TNF
26 11.64 CD247 HLA-DQB1 PTPN22
27 11.58 IL2RA IL2RB STAT4 TYK2
28
Show member pathways
11.49 CCR5 CD247 IL2RA IL2RB STAT4 TYK2
29 11.44 CCR5 TNF TYK2
30 11.42 IL2RA IL2RB STAT4
31 11.35 PTPN2 STAT4 TYK2
32
Show member pathways
11.34 CD247 IL2RA IL2RB STAT4 TNF
33
Show member pathways
11.27 FAS IL2RA IL2RB TNF
34
Show member pathways
11.19 IL2RA STAT4 TYK2
35 11.16 CD247 IL2RA STAT4

GO Terms for Oligoarticular Juvenile Idiopathic Arthritis

Cellular components related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CCR5 CXCR3 FAS IL2RA TNF
2 external side of plasma membrane GO:0009897 9.1 CCR5 CXCR3 FAS IL2RA IL2RB TNF

Biological processes related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 CCR5 FAS HLA-DQB1 IL2RA TNF
2 cell surface receptor signaling pathway GO:0007166 9.76 CCR5 CD247 CXCR3 IL2RA
3 MAPK cascade GO:0000165 9.73 CCR5 IL2RA IL2RB TNF
4 positive regulation of protein phosphorylation GO:0001934 9.71 BMP4 FAS TNF
5 T cell receptor signaling pathway GO:0050852 9.7 CD247 HLA-DQB1 PTPN22
6 negative regulation of myoblast differentiation GO:0045662 9.51 BMP4 TNF
7 negative regulation of T cell receptor signaling pathway GO:0050860 9.49 PTPN2 PTPN22
8 renal system process GO:0003014 9.48 BMP4 FAS
9 negative regulation of lipid storage GO:0010888 9.4 PTPN2 TNF
10 inflammatory response GO:0006954 9.35 CCR5 CXCR3 FAS IL2RA TNF
11 necroptotic signaling pathway GO:0097527 9.32 FAS TNF
12 activation-induced cell death of T cells GO:0006924 9.26 FAS IL2RA
13 interleukin-2-mediated signaling pathway GO:0038110 9.16 IL2RA IL2RB
14 regulation of leukocyte migration GO:0002685 8.62 CXCR3 PTPN22

Molecular functions related to Oligoarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.62 CCR5 CXCR3 FAS STAT4
2 chemokine receptor activity GO:0004950 9.26 CCR5 CXCR3
3 protein tyrosine kinase binding GO:1990782 9.16 CD247 PTPN22
4 interleukin-2 receptor activity GO:0004911 8.96 IL2RA IL2RB
5 interleukin-2 binding GO:0019976 8.62 IL2RA IL2RB

Sources for Oligoarticular Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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