MOA
MCID: OLG006
MIFTS: 50

Oligoastrocytoma (MOA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Oligoastrocytoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Oligoastrocytoma is a brain tumor that forms when two types of cells in the brain, called oligodendrocytes and astrocytes, rapidly increase in number to form a mass.  these brain cells are known as glial cells, which normally protect and support nerve cells in the brain.  because an oligoastrocytoma is made up of a combination of two cell types, it is known as a mixed glioma.  oligoastrocytomas usually occur in a part of the brain called the cerebrum and are diagnosed in adults between the ages of 30 and 50.  the exact cause of this condition is unknown. last updated: 10/5/2012

MalaCards: Oligoastrocytoma, also known as mixed oligoastrocytoma, is related to oligodendroglioma and anaplastic oligodendroglioma. An important gene associated with Oligoastrocytoma is NES (nestin), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds n-ethyl-n-nitrosourea and sarcnu have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Wikipedia:65 Oligoastrocytomas are a subset of brain tumors that present with an appearance of mixed glial cell... more...

Aliases & Classifications for Oligoastrocytoma

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62UMLS, 43NIH Rare Diseases, 22GTR, 49Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

oligoastrocytoma 43 22 49
mixed oligoastrocytoma 49 62
anaplastic oligoastrocytoma 62
moa 49


External Ids:

SNOMED-CT via Orphanet59 22217002, 253071005
UMLS via Orphanet63 C0280793

Related Diseases for Oligoastrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Oligoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.1GFAP, MGMT
2anaplastic oligodendroglioma30.7MGMT, GFAP, PDGFRA
3astrocytoma30.3MGMT, IDH1, GFAP, TP53, NES, CXCR4
4anaplastic astrocytoma30.2PDGFRA, NES, TP53, GFAP, MGMT
5leukemia29.9MGMT, ID4, IDH1, TP53, NES, CXCR4
6anaplastic oligoastrocytoma10.6
7subependymal giant cell astrocytoma10.1GFAP
8giant cell glioblastoma10.1GFAP
9gliosarcoma10.1GFAP
10gliomatosis cerebri10.1GFAP
11gemistocytic astrocytoma10.1GFAP
12anaplastic ependymoma10.1GFAP
13pineoblastoma10.1GFAP
14ganglioglioma10.1GFAP
15hemangioblastoma10.1NES, GFAP
16choroid plexus papilloma10.1TP53, GFAP
17chondroma10.1PDGFRA
18meningioma10.1GFAP, PDGFB
19mixed glioma10.1GFAP, PDGFRA
20retinal detachment10.1PDGFB, GFAP
21barrett's esophagus10.1MGMT, TP53
22teratoma10.1NES, GFAP
23chordoma10.0PDGFRA, GFAP
24malignant peripheral nerve sheath tumor10.0PDGFRA, NES
25neurilemmoma10.0GFAP, NES, PDGFRA
26lung benign neoplasm10.0PDGFB, TP53, MGMT
27leiomyosarcoma10.0PDGFRA, NES, TP53
28desmoid tumor10.0PDGFRA, PDGFB
29pilocytic astrocytoma10.0MGMT, IDH1, GFAP, NES
30brain cancer10.0NES, TP53, GFAP, IDH1
31stomach cancer10.0PDGFB, TP53, MGMT
32lung small cell carcinoma10.0MGMT, TP53, PDGFRA
33gastrointestinal stromal tumor10.0PDGFRA, NES
34ependymoma10.0MGMT, GFAP, NES, PDGFRA
35arteriosclerosis10.0PDGFB, PDGFRA
36squamous cell carcinoma of the head and neck10.0MGMT, TP53, CXCR4
37cysticercosis10.0
38cerebritis10.0
39acute myeloid leukemia10.0
40dermatomyositis10.0
41dystonia10.0
42focal dystonia10.0
43lymphoblastic leukemia10.0
44myeloid leukemia10.0
45turcot syndrome10.0
46rhabdomyosarcoma10.0PDGFB, PDGFRA, NES, TP53
47sarcoma10.0PDGFB, PDGFRA, NES, TP53
48adenoma10.0MGMT, TP53, NES, CXCR4
49hypertrophy of breast10.0GFAP, NES, PDGFB
50colorectal cancer10.0CXCR4, TP53, MGMT

Graphical network of the top 20 diseases related to Oligoastrocytoma:



Diseases related to oligoastrocytoma

Symptoms for Oligoastrocytoma

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Drugs & Therapeutics for Oligoastrocytoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Oligoastrocytoma

Search NIH Clinical Center for Oligoastrocytoma

Genetic Tests for Oligoastrocytoma

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22GTR
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Genetic tests related to Oligoastrocytoma:

id Genetic test Affiliating Genes
1 Oligoastrocytoma22

Anatomical Context for Oligoastrocytoma

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33MalaCards
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MalaCards organs/tissues related to Oligoastrocytoma:

33
Brain, Bone marrow, Bone, Myeloid

Animal Models for Oligoastrocytoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Oligoastrocytoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8MGMT, TP53, FABP7, PDGFRA, PDGFB
2MP:00053888.5PDGFB, PDGFRA, CXCR4, CIC, TP53
3MP:00053698.5GFAP, TP53, CXCR4, PDGFRA, PDGFB
4MP:00053808.4TP53, NES, CXCR4, PDGFRA, PDGFB
5MP:00053868.1ID4, GFAP, TP53, CIC, NES, FABP7
6MP:00053848.1PDGFRA, CXCR4, NES, TP53, GFAP, ID4
7MP:00053877.8IDH1, GFAP, TP53, CXCR4, PDGFRA, PDGFB
8MP:00053767.7MGMT, IDH1, GFAP, TP53, FABP7, CXCR4
9MP:00053787.5ID4, GFAP, TP53, CIC, NES, CXCR4
10MP:00107687.3MGMT, ID4, GFAP, TP53, CIC, NES
11MP:00036317.2PDGFB, ID4, GFAP, TP53, CIC, NES

Publications for Oligoastrocytoma

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52PubMed
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Articles related to Oligoastrocytoma:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
2
Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: a case report with genetic characterization. (22752622)
2013
3
Experiential auditory hallucinations due to chronic epileptic discharges after radiotherapy for oligoastrocytoma. (23774105)
2013
4
New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951. (23896377)
2013
5
Analysis of CIC-associated CpG-island methylation in oligoastrocytoma. (23521081)
2013
6
Cerebellar low-grade oligoastrocytoma presenting with subarachnoid haemorrhage. (22665014)
2012
7
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. (22588899)
2012
8
Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. (21069360)
2011
9
Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma. (20556480)
2011
10
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-. (20505301)
2010
11
Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination. (19876600)
2010
12
Novel genomic alterations and mechanisms associated with tumor progression in oligodendroglioma and mixed oligoastrocytoma. (19225409)
2009
13
Oligoastrocytoma of the brain in a hooded crane (Grus monacha). (19261644)
2009
14
A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma. (18317968)
2008
15
Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. (17660801)
2007
16
Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. (17431544)
2007
17
Oligoastrocytoma presenting with intractable epilepsy. (17884756)
2007
18
Intradural extramedullary spinal spread of oligoastrocytoma. (17582770)
2007
19
Malignant transformation of oligoastrocytoma: a case report. (18095133)
2007
20
Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma. (18077983)
2007
21
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
22
Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas. (17031656)
2007
23
Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia. (17043901)
2007
24
Paroxysmal focal dystonia with sensory symptoms secondary to cortical oligoastrocytoma. (16598615)
2006
25
Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. (16760646)
2006
26
Positive reaction for cysticercosis and multicentric anaplastic oligoastrocytoma. (15778869)
2006
27
Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years. (16292485)
2006
28
Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval. (15925987)
2005
29
Fractionated stereotactic radiation therapy in the management of primary oligodendroglioma and oligoastrocytoma. (15936562)
2005
30
Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (16018821)
2005
31
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study. (15701287)
2005
32
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
33
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
34
Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma: a long-term analysis. (15329912)
2004
35
Low-grade glioma: supratentorial astrocytoma, oligodendroglioma, and oligoastrocytoma in adults. (15102347)
2004
36
Cytoplasmic crystalline inclusions in a anaplastic oligoastrocytoma. (15471429)
2004
37
Primary spinal oligoastrocytoma: a case report. (14706386)
2004
38
Metastasis of frontal oligoastrocytoma to cerebellar vermis. (15626862)
2004
39
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. (12525516)
2003
40
Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia. (12853693)
2003
41
A phase II study of topotecan in patients with anaplastic oligodendroglioma or anaplastic mixed oligoastrocytoma. (14586216)
2003
42
Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. (12107116)
2002
43
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. (10561351)
1999
44
Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. (9663425)
1998
45
Clinicohistological study of oligodendroglioma and oligoastrocytoma. (9384800)
1997
46
Molecular genetic evidence for subtypes of oligoastrocytomas. (9329453)
1997
47
Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. (8692997)
1996
48
Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. (7815084)
1995
49
Heterotransplantation of a human oligoastrocytoma into nude mice: difference in tumour growth between males and females. (1579199)
1992
50
Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma. (6391068)
1984

Variations for Oligoastrocytoma

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Expression for genes affiliated with Oligoastrocytoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligoastrocytoma

Search GEO for disease gene expression data for Oligoastrocytoma.

Pathways for genes affiliated with Oligoastrocytoma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome, 30KEGG, 53QIAGEN
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Pathways related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PDGF Pathway38
9.6PDGFRA, PDGFB
29.6PDGFB, PDGFRA
3
Show member pathways
Angiogenesis38
9.6PDGFRA, PDGFB
4
Show member pathways
9.3PDGFB, PDGFRA, GFAP
59.3TP53, PDGFRA, PDGFB
6
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3PDGFB, PDGFRA, TP53
7
Show member pathways
Signaling Pathways in Glioblastoma38
9.3PDGFB, PDGFRA, TP53
89.3PDGFB, PDGFRA, TP53
9
Show member pathways
MAPK signaling pathway38
9.3PDGFB, PDGFRA, TP53
109.0PDGFB, PDGFRA, TP53, MGMT
11
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
12
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
13
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
14
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
15
Show member pathways
8.5GFAP, TP53, CXCR4, PDGFRA, PDGFB

Compounds for genes affiliated with Oligoastrocytoma

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45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR
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Compounds related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1n-ethyl-n-nitrosourea4510.3GFAP, MGMT
2sarcnu4510.3TP53, MGMT
3acnu4510.3TP53, MGMT
4o6-benzylguanine4510.3TP53, MGMT
5lomustine45 1111.2TP53, MGMT
6chlorambucil45 1111.2TP53, MGMT
75-methylcytosine45 2411.2MGMT, TP53
8sn 3845 6111.1TP53, MGMT
9o6-methylguanine4510.1TP53, MGMT
102-mercaptoethanol4510.1NES, GFAP
11streptozotocin4510.1MGMT, GFAP, NES
12temozolomide45 1111.1MGMT, TP53, NES
13bcnu4510.0TP53, GFAP, MGMT
14dmpq dihydrochloride6110.0PDGFRA, PDGFB
15su 16f6110.0PDGFRA, PDGFB
16crcs4510.0TP53, MGMT
17su 66686110.0PDGFRA, PDGFB
18sunitinib malate6110.0PDGFRA, PDGFB
19methylmethanesulfonate459.9TP53, MGMT
20bromodeoxyuridine459.9GFAP, NES, PDGFB
21gaba459.8GFAP, NES, FABP7
22dutp459.8TP53, GFAP
23carboplatin45 51 1111.7MGMT, TP53, CXCR4
24cyclophosphamide45 51 1111.7MGMT, TP53, CXCR4
255-aza-2deoxycytidine459.7CXCR4, TP53, MGMT
26matrigel459.6GFAP, NES, CXCR4
27topotecan45 1110.6TP53, MGMT
28agar459.5PDGFB, CXCR4, GFAP
29paclitaxel45 51 1111.5MGMT, GFAP, TP53, CXCR4
30butyrate459.5GFAP, TP53, CXCR4
31cisplatin45 51 61 1112.4CXCR4, TP53, GFAP, MGMT
32imatinib45 51 1111.4PDGFB, PDGFRA, CXCR4
33progesterone45 29 61 24 1113.4PDGFB, NES, TP53, GFAP, MGMT
34cycloheximide459.3PDGFB, CXCR4, TP53, GFAP
35dexamethasone45 51 29 1112.2PDGFB, CXCR4, GFAP, MGMT
36thymidine45 2410.2MGMT, GFAP, TP53, PDGFRA, PDGFB
37glutamate459.1IDH1, GFAP, NES, FABP7, CXCR4
38glucose459.1MGMT, GFAP, NES, CXCR4, PDGFB
39nitric oxide45 24 1111.0MGMT, NES, CXCR4, PDGFB
40paraffin458.9PDGFB, PDGFRA, NES, TP53, GFAP, MGMT
41oligonucleotide458.9MGMT, TP53, CXCR4, PDGFRA, PDGFB
42retinoic acid45 249.5MGMT, GFAP, TP53, NES, FABP7, CXCR4
43vegf458.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA
44estrogen458.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA

GO Terms for genes affiliated with Oligoastrocytoma

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16Gene Ontology
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Cellular components related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.9PDGFB, PDGFRA, CXCR4, FABP7, NES, TP53

Biological processes related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to ionizing radiationGO:07147910.1TP53, MGMT
2positive regulation of reactive oxygen species metabolic processGO:20003799.9TP53, PDGFB
3negative regulation of platelet activationGO:0105449.8PDGFB, PDGFRA
4positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRA, PDGFB
5regulation of chemotaxisGO:0509209.7PDGFRA, CXCR4
6platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRA, PDGFB
7positive regulation of DNA replicationGO:0457409.7PDGFB, PDGFRA
8cellular protein localizationGO:0346139.6TP53, ID4
9cell chemotaxisGO:0603269.5PDGFRA, PDGFB
10extracellular matrix organizationGO:0301989.3PDGFB, PDGFRA, GFAP
11positive regulation of fibroblast proliferationGO:0481469.3PDGFRA, PDGFB

Molecular functions related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.6TP53, ID4
2platelet-derived growth factor bindingGO:0484079.5PDGFB, PDGFRA
3platelet-derived growth factor receptor bindingGO:0051619.3PDGFB, PDGFRA

Products for genes affiliated with Oligoastrocytoma

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Sources for Oligoastrocytoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet