MOA
MCID: OLG006
MIFTS: 50

Oligoastrocytoma (MOA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Oligoastrocytoma

About this section
Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Oligoastrocytoma isĀ a brain tumor that forms when two types of cells in the brain, calledĀ oligodendrocytes and astrocytes, rapidly increase in number to form a mass.Ā  these brain cells are known as glial cells, which normally protect and support nerve cells in the brain.Ā  because an oligoastrocytoma is made up of a combination of two cell types, it is known as a mixed glioma.Ā  oligoastrocytomas usually occur in a part of the brain called the cerebrum and are diagnosed in adults between the ages of 30 and 50.Ā  the exact cause of this condition is unknown. last updated: 10/5/2012

MalaCards: Oligoastrocytoma, also known as mixed oligoastrocytoma, is related to oligodendroglioma and anaplastic oligodendroglioma. An important gene associated with Oligoastrocytoma is NES (nestin), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds n-ethyl-n-nitrosourea and sarcnu have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Wikipedia:66 Oligoastrocytomas are a subset of brain tumors that present with an appearance of mixed glial cell... more...

Aliases & Classifications for Oligoastrocytoma

About this section
Sources:
63UMLS, 44NIH Rare Diseases, 23GTR, 50Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

oligoastrocytoma 44 23 50
mixed oligoastrocytoma 50 63
anaplastic oligoastrocytoma 63
moa 50


External Ids:

SNOMED-CT via Orphanet60 22217002, 253071005
UMLS via Orphanet64 C0280793

Related Diseases for Oligoastrocytoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Oligoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.1GFAP, MGMT
2anaplastic oligodendroglioma30.7MGMT, GFAP, PDGFRA
3astrocytoma30.3MGMT, IDH1, GFAP, TP53, NES, CXCR4
4anaplastic astrocytoma30.2PDGFRA, NES, TP53, GFAP, MGMT
5leukemia29.9MGMT, ID4, IDH1, TP53, NES, CXCR4
6anaplastic oligoastrocytoma10.6
7subependymal giant cell astrocytoma10.1GFAP
8giant cell glioblastoma10.1GFAP
9gliosarcoma10.1GFAP
10gliomatosis cerebri10.1GFAP
11gemistocytic astrocytoma10.1GFAP
12anaplastic ependymoma10.1GFAP
13pineoblastoma10.1GFAP
14ganglioglioma10.1GFAP
15hemangioblastoma10.1NES, GFAP
16choroid plexus papilloma10.1TP53, GFAP
17chondroma10.1PDGFRA
18meningioma10.1GFAP, PDGFB
19mixed glioma10.1GFAP, PDGFRA
20retinal detachment10.1PDGFB, GFAP
21barrett's esophagus10.1MGMT, TP53
22teratoma10.1NES, GFAP
23chordoma10.0PDGFRA, GFAP
24malignant peripheral nerve sheath tumor10.0PDGFRA, NES
25neurilemmoma10.0GFAP, NES, PDGFRA
26lung benign neoplasm10.0PDGFB, TP53, MGMT
27leiomyosarcoma10.0PDGFRA, NES, TP53
28desmoid tumor10.0PDGFRA, PDGFB
29pilocytic astrocytoma10.0MGMT, IDH1, GFAP, NES
30brain cancer10.0NES, TP53, GFAP, IDH1
31stomach cancer10.0PDGFB, TP53, MGMT
32lung small cell carcinoma10.0MGMT, TP53, PDGFRA
33gastrointestinal stromal tumor10.0PDGFRA, NES
34ependymoma10.0MGMT, GFAP, NES, PDGFRA
35arteriosclerosis10.0PDGFB, PDGFRA
36squamous cell carcinoma of the head and neck10.0MGMT, TP53, CXCR4
37cysticercosis10.0
38cerebritis10.0
39acute myeloid leukemia10.0
40dermatomyositis10.0
41dystonia10.0
42focal dystonia10.0
43lymphoblastic leukemia10.0
44myeloid leukemia10.0
45turcot syndrome10.0
46rhabdomyosarcoma10.0PDGFB, PDGFRA, NES, TP53
47sarcoma10.0PDGFB, PDGFRA, NES, TP53
48adenoma10.0MGMT, TP53, NES, CXCR4
49hypertrophy of breast10.0GFAP, NES, PDGFB
50colorectal cancer10.0CXCR4, TP53, MGMT

Graphical network of the top 20 diseases related to Oligoastrocytoma:



Diseases related to oligoastrocytoma

Symptoms for Oligoastrocytoma

About this section

Drugs & Therapeutics for Oligoastrocytoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oligoastrocytoma

Drug clinical trials:

Search ClinicalTrials for Oligoastrocytoma

Search NIH Clinical Center for Oligoastrocytoma

Search CenterWatch for Oligoastrocytoma

Genetic Tests for Oligoastrocytoma

About this section
Sources:
23GTR
See all sources

Genetic tests related to Oligoastrocytoma:

id Genetic test Affiliating Genes
1 Oligoastrocytoma23

Anatomical Context for Oligoastrocytoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Oligoastrocytoma:

34
Brain, Bone marrow, Bone, Myeloid

Animal Models for Oligoastrocytoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Oligoastrocytoma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8MGMT, TP53, FABP7, PDGFRA, PDGFB
2MP:00053888.5PDGFB, PDGFRA, CXCR4, CIC, TP53
3MP:00053698.5GFAP, TP53, CXCR4, PDGFRA, PDGFB
4MP:00053808.4TP53, NES, CXCR4, PDGFRA, PDGFB
5MP:00053868.1ID4, GFAP, TP53, CIC, NES, FABP7
6MP:00053848.1PDGFRA, CXCR4, NES, TP53, GFAP, ID4
7MP:00053877.8IDH1, GFAP, TP53, CXCR4, PDGFRA, PDGFB
8MP:00053767.7MGMT, IDH1, GFAP, TP53, FABP7, CXCR4
9MP:00053787.5ID4, GFAP, TP53, CIC, NES, CXCR4
10MP:00107687.3MGMT, ID4, GFAP, TP53, CIC, NES
11MP:00036317.2PDGFB, ID4, GFAP, TP53, CIC, NES

Publications for Oligoastrocytoma

About this section
Sources:
53PubMed
See all sources

Articles related to Oligoastrocytoma:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
2
Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: a case report with genetic characterization. (22752622)
2013
3
Experiential auditory hallucinations due to chronic epileptic discharges after radiotherapy for oligoastrocytoma. (23774105)
2013
4
New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951. (23896377)
2013
5
Analysis of CIC-associated CpG-island methylation in oligoastrocytoma. (23521081)
2013
6
Cerebellar low-grade oligoastrocytoma presenting with subarachnoid haemorrhage. (22665014)
2012
7
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. (22588899)
2012
8
Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. (21069360)
2011
9
Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma. (20556480)
2011
10
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-. (20505301)
2010
11
Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination. (19876600)
2010
12
Novel genomic alterations and mechanisms associated with tumor progression in oligodendroglioma and mixed oligoastrocytoma. (19225409)
2009
13
Oligoastrocytoma of the brain in a hooded crane (Grus monacha). (19261644)
2009
14
A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma. (18317968)
2008
15
Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. (17660801)
2007
16
Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. (17431544)
2007
17
Oligoastrocytoma presenting with intractable epilepsy. (17884756)
2007
18
Intradural extramedullary spinal spread of oligoastrocytoma. (17582770)
2007
19
Malignant transformation of oligoastrocytoma: a case report. (18095133)
2007
20
Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma. (18077983)
2007
21
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
22
Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas. (17031656)
2007
23
Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia. (17043901)
2007
24
Paroxysmal focal dystonia with sensory symptoms secondary to cortical oligoastrocytoma. (16598615)
2006
25
Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. (16760646)
2006
26
Positive reaction for cysticercosis and multicentric anaplastic oligoastrocytoma. (15778869)
2006
27
Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years. (16292485)
2006
28
Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval. (15925987)
2005
29
Fractionated stereotactic radiation therapy in the management of primary oligodendroglioma and oligoastrocytoma. (15936562)
2005
30
Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (16018821)
2005
31
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study. (15701287)
2005
32
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
33
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
34
Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma: a long-term analysis. (15329912)
2004
35
Low-grade glioma: supratentorial astrocytoma, oligodendroglioma, and oligoastrocytoma in adults. (15102347)
2004
36
Cytoplasmic crystalline inclusions in a anaplastic oligoastrocytoma. (15471429)
2004
37
Primary spinal oligoastrocytoma: a case report. (14706386)
2004
38
Metastasis of frontal oligoastrocytoma to cerebellar vermis. (15626862)
2004
39
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. (12525516)
2003
40
Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia. (12853693)
2003
41
A phase II study of topotecan in patients with anaplastic oligodendroglioma or anaplastic mixed oligoastrocytoma. (14586216)
2003
42
Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. (12107116)
2002
43
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. (10561351)
1999
44
Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. (9663425)
1998
45
Clinicohistological study of oligodendroglioma and oligoastrocytoma. (9384800)
1997
46
Molecular genetic evidence for subtypes of oligoastrocytomas. (9329453)
1997
47
Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. (8692997)
1996
48
Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. (7815084)
1995
49
Heterotransplantation of a human oligoastrocytoma into nude mice: difference in tumour growth between males and females. (1579199)
1992
50
Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma. (6391068)
1984

Variations for Oligoastrocytoma

About this section

Expression for genes affiliated with Oligoastrocytoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oligoastrocytoma

Search GEO for disease gene expression data for Oligoastrocytoma.

Pathways for genes affiliated with Oligoastrocytoma

About this section
Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome, 31KEGG, 54QIAGEN
See all sources

Pathways related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PDGF Pathway39
9.6PDGFRA, PDGFB
29.6PDGFB, PDGFRA
3
Show member pathways
Angiogenesis39
9.6PDGFRA, PDGFB
4
Show member pathways
9.3PDGFB, PDGFRA, GFAP
59.3TP53, PDGFRA, PDGFB
6
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3PDGFB, PDGFRA, TP53
7
Show member pathways
Signaling Pathways in Glioblastoma39
9.3PDGFB, PDGFRA, TP53
89.3PDGFB, PDGFRA, TP53
9
Show member pathways
MAPK signaling pathway39
9.3PDGFB, PDGFRA, TP53
109.0PDGFB, PDGFRA, TP53, MGMT
11
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
12
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
13
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
14
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
15
Show member pathways
8.5GFAP, TP53, CXCR4, PDGFRA, PDGFB

Compounds for genes affiliated with Oligoastrocytoma

About this section
Sources:
46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR
See all sources

Compounds related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1n-ethyl-n-nitrosourea4610.3GFAP, MGMT
2sarcnu4610.3TP53, MGMT
3acnu4610.3TP53, MGMT
4o6-benzylguanine4610.3TP53, MGMT
5lomustine46 1211.2TP53, MGMT
6chlorambucil46 1211.2TP53, MGMT
75-methylcytosine46 2511.2MGMT, TP53
8sn 3846 6211.1TP53, MGMT
9o6-methylguanine4610.1TP53, MGMT
102-mercaptoethanol4610.1NES, GFAP
11streptozotocin4610.1MGMT, GFAP, NES
12temozolomide46 1211.1MGMT, TP53, NES
13bcnu4610.0TP53, GFAP, MGMT
14dmpq dihydrochloride6210.0PDGFRA, PDGFB
15su 16f6210.0PDGFRA, PDGFB
16crcs4610.0TP53, MGMT
17su 66686210.0PDGFRA, PDGFB
18sunitinib malate6210.0PDGFRA, PDGFB
19methylmethanesulfonate469.9TP53, MGMT
20bromodeoxyuridine469.9GFAP, NES, PDGFB
21gaba469.8GFAP, NES, FABP7
22dutp469.8TP53, GFAP
23carboplatin46 52 1211.7MGMT, TP53, CXCR4
24cyclophosphamide46 52 1211.7MGMT, TP53, CXCR4
255-aza-2deoxycytidine469.7CXCR4, TP53, MGMT
26matrigel469.6GFAP, NES, CXCR4
27topotecan46 1210.6TP53, MGMT
28agar469.5PDGFB, CXCR4, GFAP
29paclitaxel46 52 1211.5MGMT, GFAP, TP53, CXCR4
30butyrate469.5GFAP, TP53, CXCR4
31cisplatin46 52 62 1212.4CXCR4, TP53, GFAP, MGMT
32imatinib46 52 1211.4PDGFB, PDGFRA, CXCR4
33progesterone46 30 62 25 1213.4PDGFB, NES, TP53, GFAP, MGMT
34cycloheximide469.3PDGFB, CXCR4, TP53, GFAP
35dexamethasone46 52 30 1212.2PDGFB, CXCR4, GFAP, MGMT
36thymidine46 2510.2MGMT, GFAP, TP53, PDGFRA, PDGFB
37glutamate469.1IDH1, GFAP, NES, FABP7, CXCR4
38glucose469.1MGMT, GFAP, NES, CXCR4, PDGFB
39nitric oxide46 25 1211.0MGMT, NES, CXCR4, PDGFB
40paraffin468.9PDGFB, PDGFRA, NES, TP53, GFAP, MGMT
41oligonucleotide468.9MGMT, TP53, CXCR4, PDGFRA, PDGFB
42retinoic acid46 259.5MGMT, GFAP, TP53, NES, FABP7, CXCR4
43vegf468.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA
44estrogen468.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA

GO Terms for genes affiliated with Oligoastrocytoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.9PDGFB, PDGFRA, CXCR4, FABP7, NES, TP53

Biological processes related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to ionizing radiationGO:07147910.1TP53, MGMT
2positive regulation of reactive oxygen species metabolic processGO:20003799.9TP53, PDGFB
3negative regulation of platelet activationGO:0105449.8PDGFB, PDGFRA
4positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRA, PDGFB
5regulation of chemotaxisGO:0509209.7PDGFRA, CXCR4
6platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRA, PDGFB
7positive regulation of DNA replicationGO:0457409.7PDGFB, PDGFRA
8cellular protein localizationGO:0346139.6TP53, ID4
9cell chemotaxisGO:0603269.5PDGFRA, PDGFB
10extracellular matrix organizationGO:0301989.3PDGFB, PDGFRA, GFAP
11positive regulation of fibroblast proliferationGO:0481469.3PDGFRA, PDGFB

Molecular functions related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.6TP53, ID4
2platelet-derived growth factor bindingGO:0484079.5PDGFB, PDGFRA
3platelet-derived growth factor receptor bindingGO:0051619.3PDGFB, PDGFRA

Products for genes affiliated with Oligoastrocytoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligoastrocytoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet