MOA
MCID: OLG006
MIFTS: 39

Oligoastrocytoma (MOA) malady

Neuronal diseases, Cancer diseases categories

Summaries for Oligoastrocytoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Oligoastrocytoma is a brain tumor that forms when two types of cells in the brain, called oligodendrocytes and astrocytes, rapidly increase in number to form a mass.  these brain cells are known as glial cells, which normally protect and support nerve cells in the brain.  because an oligoastrocytoma is made up of a combination of two cell types, it is known as a mixed glioma.  oligoastrocytomas usually occur in a part of the brain called the cerebrum and are diagnosed in adults between the ages of 30 and 50.  the exact cause of this condition is unknown. last updated: 10/5/2012

MalaCards: Oligoastrocytoma, also known as mixed oligoastrocytoma, is related to oligodendroglioma and astrocytoma. An important gene associated with Oligoastrocytoma is NES (nestin), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Angiogenesis. The compounds estrogen and sarcnu have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are nervous system and no phenotypic analysis.

Wikipedia:63 Oligoastrocytomas are a subset of brain tumors that present with an appearance of mixed glial cell... more...

Aliases & Classifications for Oligoastrocytoma

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60UMLS, 42NIH Rare Diseases, 22GTR, 48Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

oligoastrocytoma 42 22 48
mixed oligoastrocytoma 48 60
anaplastic oligoastrocytoma 60
moa 48


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SNOMED-CT via Orphanet57 22217002, 253071005

Related Diseases for Oligoastrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Oligoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma30.9GFAP, MGMT
2astrocytoma30.5CXCR4, IDH1, PDGFB, MGMT, NES, GFAP
3acute leukemia30.1CXCR4, ID4
4leukemia30.1ID4, CXCR4, PDGFRA, NES, MGMT, PDGFB
5brain cancer29.9NES, IDH1, GFAP, TP53
6anaplastic oligoastrocytoma10.4
7brain oligodendroglioma10.1
8intraocular lymphoma10.0
9gliosarcoma10.0GFAP
10subependymal giant cell astrocytoma10.0GFAP
11gliomatosis cerebri10.0GFAP
12ganglioglioma10.0GFAP
13thyroid cancer10.0TP53
14anaplastic ependymoma10.0GFAP
15neuroblastoma10.0TP53
16gemistocytic astrocytoma10.0GFAP
17giant cell glioblastoma10.0GFAP
18esophageal cancer10.0TP53
19hydrocephalus10.0NES
20alzheimer's disease10.0GFAP
21cholangiocarcinoma10.0TP53
22pineoblastoma10.0GFAP
23dermatofibrosarcoma protuberans10.0PDGFB
24dermatofibrosarcoma10.0PDGFB
25multiple myeloma10.0TP53
26gallbladder cancer10.0TP53
27hepatitis10.0PDGFB
28neurofibromatosis10.0PDGFRA
29chondrosarcoma10.0PDGFRA
30myelofibrosis10.0PDGFRA
31seminoma10.0PDGFRA
32myelodysplastic syndromes10.0PDGFRA
33hemangioblastoma10.0NES, GFAP
34testicular cancer10.0MGMT
35neural tube defects10.0PDGFRA
36myoepithelioma10.0GFAP
37li-fraumeni syndrome10.0TP53
38retinoblastoma10.0GFAP, TP53
39pituitary adenoma10.0NES, MGMT
40teratoma10.0NES, GFAP
41chondroma10.0PDGFRA
42meningioma10.0PDGFB, GFAP
43oral cancer10.0MGMT, TP53
44vascular disease10.0GFAP, TP53
45choroid plexus papilloma10.0GFAP, TP53
46gastrointestinal stromal tumor10.0PDGFRA, NES
47chordoma10.0PDGFRA, GFAP
48cervical cancer10.0TP53, MGMT
49mixed glioma10.0GFAP, PDGFRA
50fibrosarcoma10.0PDGFRA, NES

Graphical network of the top 20 diseases related to Oligoastrocytoma:



Diseases related to oligoastrocytoma

Clinical Features for Oligoastrocytoma

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Drugs & Therapeutics for Oligoastrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Oligoastrocytoma

Genetic Tests for Oligoastrocytoma

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22GTR
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Genetic tests related to Oligoastrocytoma:

id Genetic test Affiliating Genes
1 Oligoastrocytoma22

Anatomical Context for Oligoastrocytoma

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32MalaCards
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MalaCards organs/tissues related to Oligoastrocytoma:

32
Brain

Animal Models for Oligoastrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oligoastrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.1GFAP, CIC, FABP7, PDGFB
2MP:00030128.8TP53, MGMT, FABP7, PDGFRA, PDGFB
3MP:00053767.6IDH1, PDGFB, PDGFRA, FABP7, MGMT, CXCR4
4MP:00053867.5ID4, PDGFRA, FABP7, CIC, NES, GFAP
5MP:00053787.3ID4, PDGFB, PDGFRA, CIC, NES, CXCR4
6MP:00107687.1ID4, PDGFB, PDGFRA, MGMT, CIC, NES

Publications for Oligoastrocytoma

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Genetic Variations for Oligoastrocytoma

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Expression for genes affiliated with Oligoastrocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligoastrocytoma

Search GEO for disease gene expression data for Oligoastrocytoma.

Pathways for genes affiliated with Oligoastrocytoma

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12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Oligoastrocytoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GFAP
2sarcnu4410.2MGMT, TP53
3n-ethyl-n-nitrosourea4410.2GFAP, MGMT
4acnu4410.2TP53, MGMT
5o6-benzylguanine4410.1MGMT, TP53
6lomustine44 1111.1MGMT, TP53
7cycloheximide4410.1PDGFB
8dmpq dihydrochloride5910.0PDGFB, PDGFRA
9streptozotocin4410.0GFAP, NES, MGMT
10su 16f5910.0PDGFB, PDGFRA
11su 66685910.0PDGFB, PDGFRA
12temozolomide44 1111.0TP53, NES, MGMT
13sunitinib malate5910.0PDGFB, PDGFRA
14bcnu4410.0MGMT, GFAP, TP53
15glucose4410.0GFAP, MGMT
16chlorambucil44 1110.9TP53, MGMT
175-methylcytosine44 2410.8MGMT, TP53
18bromodeoxyuridine449.8GFAP, NES, PDGFB
19paclitaxel44 49 1111.8CXCR4, GFAP, TP53
20carboplatin44 49 1111.7TP53, CXCR4, MGMT
21paraffin449.7GFAP, NES, MGMT, PDGFB
22cyclophosphamide44 49 1111.6TP53, CXCR4, MGMT
23imatinib44 49 1111.3PDGFB, PDGFRA, CXCR4
24progesterone44 59 28 11 2413.3PDGFB, MGMT, NES, GFAP, TP53
25cisplatin44 49 59 1112.3MGMT, CXCR4, GFAP, TP53
26thymidine44 2410.2PDGFB, PDGFRA, MGMT, GFAP, TP53
275-aza-2deoxycytidine449.1TP53, CXCR4, MGMT
28glutamate449.1IDH1, FABP7, NES, CXCR4, GFAP
29oligonucleotide448.9PDGFB, PDGFRA, MGMT, CXCR4, TP53
30retinoic acid44 249.6TP53, PDGFRA, FABP7, MGMT, NES, CXCR4
31vegf448.5PDGFRA, MGMT, NES, CXCR4, GFAP, TP53

GO Terms for genes affiliated with Oligoastrocytoma

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16Gene Ontology
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Cellular components related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.1TP53, GFAP, CXCR4, NES, FABP7, PDGFRA

Biological processes related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.8PDGFRA, PDGFB
2positive regulation of reactive oxygen species metabolic processGO:20003799.8TP53, PDGFB
3regulation of chemotaxisGO:0509209.8CXCR4, PDGFRA
4cell chemotaxisGO:0603269.8PDGFRA, PDGFB
5platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFB, PDGFRA
6positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.6PDGFB, PDGFRA
7cellular response to ionizing radiationGO:0714799.6TP53, MGMT

Molecular functions related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:0051619.7PDGFRA, PDGFB
2platelet-derived growth factor bindingGO:0484079.4PDGFRA, PDGFB

Products for genes affiliated with Oligoastrocytoma

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Sources for Oligoastrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet