MOA
MCID: OLG006
MIFTS: 49

Oligoastrocytoma (MOA) malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Oligoastrocytoma

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NIH Rare Diseases:42 Oligoastrocytoma is a brain tumor that forms when two types of cells in the brain, called oligodendrocytes and astrocytes, rapidly increase in number to form a mass.  these brain cells are known as glial cells, which normally protect and support nerve cells in the brain.  because an oligoastrocytoma is made up of a combination of two cell types, it is known as a mixed glioma.  oligoastrocytomas usually occur in a part of the brain called the cerebrum and are diagnosed in adults between the ages of 30 and 50.  the exact cause of this condition is unknown. last updated: 10/5/2012

MalaCards based summary: Oligoastrocytoma, also known as mixed oligoastrocytoma, is related to oligodendroglioma and anaplastic oligodendroglioma. An important gene associated with Oligoastrocytoma is NES (nestin), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and Osteoblast Signaling. The compounds n-ethyl-n-nitrosourea and sarcnu have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Wikipedia:64 Oligoastrocytomas are a subset of brain tumors that present with an appearance of mixed glial cell... more...

Aliases & Classifications for Oligoastrocytoma

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Sources:
42NIH Rare Diseases, 23GTR, 48Orphanet, 61UMLS, 62UMLS via Orphanet
See all sources

Oligoastrocytoma, Aliases & Descriptions:

Name: Oligoastrocytoma 42 23 48
Mixed Oligoastrocytoma 48 61
 
Anaplastic Oligoastrocytoma 61
Moa 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

UMLS via Orphanet62 C0280793

Related Diseases for Oligoastrocytoma

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Diseases related to Oligoastrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.6GFAP, MGMT
2anaplastic oligodendroglioma31.0GFAP, PDGFRA, MGMT
3mixed glioma30.4PDGFRA, GFAP
4astrocytoma29.4MGMT, IDH1, GFAP, PDGFB, TP53, NES
5leukemia28.8NES, ID4, IDH1, TP53, PDGFRA, PDGFB
6anaplastic oligoastrocytoma10.7
7subependymal giant cell astrocytoma10.5GFAP
8giant cell glioblastoma10.5GFAP
9gliosarcoma10.5GFAP
10gliomatosis cerebri10.5GFAP
11gemistocytic astrocytoma10.5GFAP
12anaplastic ependymoma10.5GFAP
13pineoblastoma10.5GFAP
14ganglioglioma10.5GFAP
15choroid plexus papilloma10.4TP53, GFAP
16hemangioblastoma10.4GFAP, NES
17chondroma10.3PDGFRA
18meningioma10.3GFAP, PDGFB
19retinal detachment10.3PDGFB, GFAP
20barrett's esophagus10.2TP53, MGMT
21chordoma10.2PDGFRA, GFAP
22teratoma10.2NES, GFAP
23malignant peripheral nerve sheath tumor10.2PDGFRA, NES
24neurilemmoma10.1PDGFRA, NES, GFAP
25lung benign neoplasm10.1MGMT, TP53, PDGFB
26leiomyosarcoma10.1TP53, NES, PDGFRA
27desmoid tumor10.1PDGFB, PDGFRA
28pilocytic astrocytoma10.1MGMT, NES, GFAP, IDH1
29brain cancer10.1IDH1, GFAP, TP53, NES
30lung small cell carcinoma10.0PDGFRA, MGMT, TP53
31stomach cancer10.0TP53, PDGFB, MGMT
32ependymoma10.0GFAP, NES, PDGFRA, MGMT
33acute lymphoblastic leukemia10.0
34acute myeloid leukemia10.0
35cysticercosis10.0
36cerebritis10.0
37dermatomyositis10.0
38dystonia10.0
39focal dystonia10.0
40lymphoblastic leukemia10.0
41myeloid leukemia10.0
42turcot syndrome10.0
43arteriosclerosis10.0PDGFRA, PDGFB
44squamous cell carcinoma of the head and neck10.0TP53, MGMT, CXCR4
45gastrointestinal stromal tumor10.0PDGFRA, NES
46rhabdomyosarcoma9.9TP53, NES, PDGFRA, PDGFB
47grade iii astrocytoma9.9GFAP, MGMT, TP53, NES, PDGFRA
48sarcoma9.9PDGFB, PDGFRA, NES, TP53
49adenoma9.9TP53, MGMT, NES, CXCR4
50colorectal cancer9.9MGMT, CXCR4, TP53

Graphical network of the top 20 diseases related to Oligoastrocytoma:



Diseases related to oligoastrocytoma

Symptoms for Oligoastrocytoma

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Drugs & Therapeutics for Oligoastrocytoma

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Drug clinical trials:

Search ClinicalTrials for Oligoastrocytoma

Search NIH Clinical Center for Oligoastrocytoma

Genetic Tests for Oligoastrocytoma

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Genetic tests related to Oligoastrocytoma:

id Genetic test Affiliating Genes
1 Oligoastrocytoma23

Anatomical Context for Oligoastrocytoma

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MalaCards organs/tissues related to Oligoastrocytoma:

32
Brain, Bone marrow, Bone, Myeloid

Animal Models for Oligoastrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Oligoastrocytoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8MGMT, TP53, FABP7, PDGFRA, PDGFB
2MP:00053888.5PDGFB, PDGFRA, CXCR4, CIC, TP53
3MP:00053698.5GFAP, TP53, CXCR4, PDGFRA, PDGFB
4MP:00053808.4TP53, NES, CXCR4, PDGFRA, PDGFB
5MP:00053868.1ID4, GFAP, TP53, CIC, NES, FABP7
6MP:00053848.1PDGFRA, CXCR4, NES, TP53, GFAP, ID4
7MP:00053877.8IDH1, GFAP, TP53, CXCR4, PDGFRA, PDGFB
8MP:00053767.7MGMT, IDH1, GFAP, TP53, FABP7, CXCR4
9MP:00053787.5ID4, GFAP, TP53, CIC, NES, CXCR4
10MP:00107687.3MGMT, ID4, GFAP, TP53, CIC, NES
11MP:00036317.2PDGFB, ID4, GFAP, TP53, CIC, NES

Publications for Oligoastrocytoma

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Articles related to Oligoastrocytoma:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
2
Clinical discussion of the management of anaplastic oligodendroglioma/oligoastrocytoma (both codeleted and nondeleted). (24812135)
2014
3
Pattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean radiation oncology group study 13-12. (25391968)
2014
4
Mixed Glioma (Oligoastrocytoma) in the Brain ofA an African Hedgehog (Atelerix albiventris). (25172052)
2014
5
Farewell to oligoastrocytoma: response to letters. (25381649)
2014
6
1p/19q codeletion and IDH1/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas. (23486687)
2013
7
Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: a case report with genetic characterization. (22752622)
2013
8
Experiential auditory hallucinations due to chronic epileptic discharges after radiotherapy for oligoastrocytoma. (23774105)
2013
9
Cerebellar low-grade oligoastrocytoma presenting with subarachnoid haemorrhage. (22665014)
2012
10
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. (22588899)
2012
11
Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. (21069360)
2011
12
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-. (20505301)
2010
13
Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination. (19876600)
2010
14
Novel genomic alterations and mechanisms associated with tumor progression in oligodendroglioma and mixed oligoastrocytoma. (19225409)
2009
15
Oligoastrocytoma of the brain in a hooded crane (Grus monacha). (19261644)
2009
16
A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma. (18317968)
2008
17
Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. (17660801)
2007
18
Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. (17431544)
2007
19
Oligoastrocytoma presenting with intractable epilepsy. (17884756)
2007
20
Intradural extramedullary spinal spread of oligoastrocytoma. (17582770)
2007
21
Malignant transformation of oligoastrocytoma: a case report. (18095133)
2007
22
Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma. (18077983)
2007
23
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
24
Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas. (17031656)
2007
25
Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia. (17043901)
2007
26
Paroxysmal focal dystonia with sensory symptoms secondary to cortical oligoastrocytoma. (16598615)
2006
27
Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. (16760646)
2006
28
Positive reaction for cysticercosis and multicentric anaplastic oligoastrocytoma. (15778869)
2006
29
Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval. (15925987)
2005
30
Fractionated stereotactic radiation therapy in the management of primary oligodendroglioma and oligoastrocytoma. (15936562)
2005
31
Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (16018821)
2005
32
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study. (15701287)
2005
33
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
34
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
35
Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma: a long-term analysis. (15329912)
2004
36
Low-grade glioma: supratentorial astrocytoma, oligodendroglioma, and oligoastrocytoma in adults. (15102347)
2004
37
Cytoplasmic crystalline inclusions in a anaplastic oligoastrocytoma. (15471429)
2004
38
Primary spinal oligoastrocytoma: a case report. (14706386)
2004
39
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. (12525516)
2003
40
Carboplatin and teniposide as third-line chemotherapy in patients with recurrent oligodendroglioma or oligoastrocytoma: a phase II study. (14630676)
2003
41
Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia. (12853693)
2003
42
A phase II study of topotecan in patients with anaplastic oligodendroglioma or anaplastic mixed oligoastrocytoma. (14586216)
2003
43
Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. (12107116)
2002
44
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. (10561351)
1999
45
Clinicohistological study of oligodendroglioma and oligoastrocytoma. (9384800)
1997
46
Molecular genetic evidence for subtypes of oligoastrocytomas. (9329453)
1997
47
Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. (8692997)
1996
48
Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. (7815084)
1995
49
Heterotransplantation of a human oligoastrocytoma into nude mice: difference in tumour growth between males and females. (1579199)
1992
50
Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma. (6391068)
1984

Variations for Oligoastrocytoma

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Expression for genes affiliated with Oligoastrocytoma

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Expression patterns in normal tissues for genes affiliated with Oligoastrocytoma

Search GEO for disease gene expression data for Oligoastrocytoma.

Pathways for genes affiliated with Oligoastrocytoma

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Pathways related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PDGF Pathway37
9.6PDGFRA, PDGFB
29.6PDGFB, PDGFRA
3
Show member pathways
Angiogenesis37
9.6PDGFRA, PDGFB
4
Show member pathways
9.3PDGFB, PDGFRA, GFAP
59.3TP53, PDGFRA, PDGFB
6
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.3PDGFB, PDGFRA, TP53
7
Show member pathways
Signaling Pathways in Glioblastoma37
9.3PDGFB, PDGFRA, TP53
89.3PDGFB, PDGFRA, TP53
9
Show member pathways
MAPK signaling pathway37
9.3PDGFB, PDGFRA, TP53
109.0PDGFB, PDGFRA, TP53, MGMT
11
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
12
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
13
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
14
Show member pathways
8.8TP53, CXCR4, PDGFRA, PDGFB
15
Show member pathways
8.5GFAP, TP53, CXCR4, PDGFRA, PDGFB

Compounds for genes affiliated with Oligoastrocytoma

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Compounds related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1n-ethyl-n-nitrosourea4410.3GFAP, MGMT
2sarcnu4410.3TP53, MGMT
3acnu4410.3TP53, MGMT
4o6-benzylguanine4410.3TP53, MGMT
5lomustine44 1211.2TP53, MGMT
6chlorambucil44 1211.2TP53, MGMT
75-methylcytosine44 2511.2MGMT, TP53
8sn 3844 6011.1TP53, MGMT
9o6-methylguanine4410.1TP53, MGMT
102-mercaptoethanol4410.1NES, GFAP
11streptozotocin4410.1MGMT, GFAP, NES
12temozolomide44 1211.1MGMT, TP53, NES
13bcnu4410.0TP53, GFAP, MGMT
14dmpq dihydrochloride6010.0PDGFRA, PDGFB
15su 16f6010.0PDGFRA, PDGFB
16crcs4410.0TP53, MGMT
17su 66686010.0PDGFRA, PDGFB
18sunitinib malate6010.0PDGFRA, PDGFB
19methylmethanesulfonate449.9TP53, MGMT
20bromodeoxyuridine449.9GFAP, NES, PDGFB
21gaba449.8GFAP, NES, FABP7
22dutp449.8TP53, GFAP
23carboplatin44 50 1211.7MGMT, TP53, CXCR4
24cyclophosphamide44 50 1211.7MGMT, TP53, CXCR4
255-aza-2deoxycytidine449.7CXCR4, TP53, MGMT
26matrigel449.6GFAP, NES, CXCR4
27topotecan44 1210.6TP53, MGMT
28agar449.5PDGFB, CXCR4, GFAP
29paclitaxel44 50 1211.5MGMT, GFAP, TP53, CXCR4
30butyrate449.5GFAP, TP53, CXCR4
31cisplatin44 50 60 1212.4CXCR4, TP53, GFAP, MGMT
32imatinib44 50 1211.4PDGFB, PDGFRA, CXCR4
33progesterone44 29 60 25 1213.4PDGFB, NES, TP53, GFAP, MGMT
34cycloheximide449.3PDGFB, CXCR4, TP53, GFAP
35dexamethasone44 50 29 1212.2PDGFB, CXCR4, GFAP, MGMT
36thymidine44 2510.2MGMT, GFAP, TP53, PDGFRA, PDGFB
37glutamate449.1IDH1, GFAP, NES, FABP7, CXCR4
38glucose449.1MGMT, GFAP, NES, CXCR4, PDGFB
39nitric oxide44 25 1211.0MGMT, NES, CXCR4, PDGFB
40paraffin448.9PDGFB, PDGFRA, NES, TP53, GFAP, MGMT
41oligonucleotide448.9MGMT, TP53, CXCR4, PDGFRA, PDGFB
42retinoic acid44 259.5MGMT, GFAP, TP53, NES, FABP7, CXCR4
43vegf448.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA
44estrogen448.4MGMT, GFAP, TP53, NES, CXCR4, PDGFRA

GO Terms for genes affiliated with Oligoastrocytoma

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Cellular components related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.9PDGFB, PDGFRA, CXCR4, FABP7, NES, TP53

Biological processes related to Oligoastrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to ionizing radiationGO:07147910.1TP53, MGMT
2positive regulation of reactive oxygen species metabolic processGO:20003799.9TP53, PDGFB
3negative regulation of platelet activationGO:0105449.8PDGFB, PDGFRA
4positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRA, PDGFB
5regulation of chemotaxisGO:0509209.7PDGFRA, CXCR4
6platelet-derived growth factor receptor signaling pathwayGO:0480089.7PDGFRA, PDGFB
7positive regulation of DNA replicationGO:0457409.7PDGFB, PDGFRA
8cellular protein localizationGO:0346139.6TP53, ID4
9cell chemotaxisGO:0603269.5PDGFRA, PDGFB
10extracellular matrix organizationGO:0301989.3PDGFB, PDGFRA, GFAP
11positive regulation of fibroblast proliferationGO:0481469.3PDGFRA, PDGFB

Molecular functions related to Oligoastrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.6TP53, ID4
2platelet-derived growth factor bindingGO:0484079.5PDGFB, PDGFRA
3platelet-derived growth factor receptor bindingGO:0051619.3PDGFB, PDGFRA

Products for genes affiliated with Oligoastrocytoma

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Sources for Oligoastrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet