Oligodendroglioma malady

Wikipedia: Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the...⁴⁴ more...

MalaCards: Oligodendroglioma, also known as oligodendroglial neoplasm, is related to anaplastic oligodendroglioma and diffuse astrocytoma. An important gene associated with Oligodendroglioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Glioblastoma Multiforme and Cell cycle. The compounds cyclophosphamide and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

oligodendroglioma 6 7 30 8 32 43 oligodendroglial neoplasm 6 43 oligodendroglioma nos (morphologic abnormality) 6

oligodendroglioma (morphologic abnormality) 6 oligodendroglial tumors 32 oligodendroglial tumor 6

Diseases related to oligodendroglioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 793)

id	Related Disease	Score	Top Affiliating Genes
1	anaplastic oligodendroglioma	34.4	PIK3CA, RB1, KDR, LGALS3, L1CAM, CDKN2C
2	diffuse astrocytoma	31.8	PCNA, LGALS3, CDKN2B, CDKN2A, CDK4, MKI67
3	oligoastrocytoma	31.5	MGMT, FABP7, FAM5C, ID4, IDH1, TP53
4	pilocytic astrocytoma	29.1	VEGFA, KDR, LGALS1, LGALS3, CDKN1A, CDKN2A
5	central neurocytoma	28.9	MAP2, GFAP, SYP
6	dysembryoplastic neuroepithelial tumor	28.9	BCL2L1, CHGA, MVP, MKI67, GRIN1, MAP2
7	cafe-au-lait spots	28.1	MSH2, MSH6, MLH1, PMS2
8	glioblastoma	28.0	PIK3CA, KLF6, RB1, VHL, VEGFA, KDR
9	anaplastic astrocytoma	27.7	PCNA, RB1, VEGFA, LGALS1, LGALS3, CDKN2B
10	dna topoisomerase ii	27.7	PCNA, BCL2L1, CDKN1A, CDK2, MKI67, IFI27
11	ependymoma	27.3	NCAM1, RB1, VIM, BRCA2, VEGFA, LGALS3
12	immunodeficiency	26.4	LGALS1, IL2, IL2RA, MBP, HSPG2, HSPA4
13	medulloblastoma	24.9	PIK3CA, NCAM1, PCNA, RB1, VIM, BRCA2
14	astrocytoma	23.1	PIK3CA, KLF6, NCAM1, PDE3B, PCNA, RB1
15	hypoxia	19.5	PIK3CA, PCNA, RB1, VHL, VEGFA, KDR
16	neuronitis	17.2	PIK3CA, KLF6, NCAM1, PDE3B, CNP, PCNA
17	supratentorial primitive neuroectodermal tumor	14.3	IDH1, TP53, PTEN, DMBT1, PDGFRA, GFAP
18	adenosquamous carcinoma	14.3	PCNA, KDR, CDKN2A, MKI67, TP53, PDGFRA
19	gliomatosis cerebri	14.3	RB1, CDKN1A, CDKN2A, CD44, INA, MDM2
20	pleomorphic xanthoastrocytoma	14.3	CDKN2B, CDKN2A, CDK4, MDM2, TUBB, TP53
21	familial melanoma	14.3	CDKN2C, CDKN2A, CDK4, MGMT, MDM2
22	lung benign neoplasm	14.2	NCAM1, RB1, KDR, LGALS1, CHGA, MVP
23	nodular melanoma	14.2	RB1, CDKN2A, CDK4, MKI67, TP53
24	adult astrocytic tumour	14.2	LGALS3, CDKN2A, MDM2, GLTSCR1, TP53
25	male germ cell tumor	14.2	CDKN1A, CDK2, CDKN2A, MGMT, MDM2, CCNA2
26	chondroma	14.2	CDK4, MDM2, IDH1, IDH2, PDGFRA
27	primary malignant lymphoma	14.1	PIK3CA, CDKN2B, CDKN2A, TP53
28	anaplastic ependymoma	14.1	MGMT, MDM2, PTEN, NF2, GFAP
29	niemann–pick disease	14.1	CNP, UGT8, APOD, MBP, SMPD1, PLP1
30	acid sphingomyelinase deficiency	14.1	CNP, UGT8, MBP, SMPD1, PLP1
31	giant cell glioblastoma	14.1	VIM, MDM2, TP53, PTEN, EGFR, GFAP
32	gliosis	14.1	MBP, MAP2, HSPG2, CA2, GLUL, GJA1
33	brain malformations	14.1	L1CAM, MBP, MAP2, GLUL, TUBB, SYP
34	ring chromosomes	14.1	CDK4, MDM2, PDGFB, EGFR, GFAP
35	acute lymphoblastic leukemia, childhood	14.1	CDKN2C, CDKN2B, CDKN1B, CDKN2A, MDM2
36	myoma	14.1	CDKN2A, MDM2, EGFR, ACTC1
37	cardia cancer	14.1	CDKN2A, CD44, GSTT1, MDM2, TP53
38	bladder urothelial papillary carcinoma	14.1	CDKN2B, MKI67, IFI27, TP53, PTGS1
39	pineocytoma	14.1	CHGA, MBP, GFAP, TAG, SYP
40	follicular adenoma	14.0	LGALS3, MKI67, MCM2, MCM7, PTEN
41	verrucous carcinoma	14.0	PCNA, RB1, CDKN1A, CDKN2A, CD44, MDM2
42	pulmonary neuroendocrine tumor	14.0	RB1, CHGA, CDKN2A, MKI67, TP53
43	merkel cell carcinoma	14.0	NCAM1, KDR, CHGA, MAP2, SYP
44	parathyroid carcinoma	14.0	RB1, BRCA2, LGALS3, MKI67, TP53
45	alveolar rhabdomyosarcoma	14.0	RB1, VIM, MDM2, IGFBP2, PDGFRA, SYP
46	developmental disabilities	14.0	GJA1, EDNRB, ELN, TSC1, DCX, SOX10
47	myxopapillary ependymoma	14.0	NCAM1, VIM, LGALS3, CA2, GFAP
48	embryonal sarcoma	14.0	VIM, CDK4, MKI67, MDM2, TP53
49	ovarian cancer	14.0	RB1, BRCA2, CDKN1A, CDKN2C, CDK2, CDKN2B
50	mesenchymal cell neoplasm	14.0	PCNA, CD44, GFAP, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to oligodendroglioma:

²²

MGI Mouse Phenotypes related to oligodendroglioma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	CNP, CIC, OLIG2, SMPD1, NOS1, NF2
2	craniofacial phenotype	MP:0005382	10.2	L1CAM, HSPG2, GJA1, TP73, CRYAB, NOTCH2
3	pigmentation phenotype	MP:0001186	9.8	PDE3B, RB1, BCL2, L1CAM, CDKN1B, CDKN2A
4	hematopoietic system phenotype	MP:0005397	9.4	KLF6, PCNA, BRCA2, VHL, RAD54L, BCL2
5	liver/biliary system phenotype	MP:0005370	9.3	KLF6, VHL, VEGFA, FTH1, FECH, IL2
6	embryogenesis phenotype	MP:0005380	9.2	PIK3CA, KLF6, VIM, BRCA2, VHL, FXN
7	endocrine/exocrine gland phenotype	MP:0005379	9.1	CNP, BRCA2, CDKN2C, CDKN2B, CDKN1B, ARHGDIA
8	no phenotypic analysis	MP:0003012	9.1	PCNA, RB1, VEGFA, L1CAM, FXN, CDKN1B
9	nervous system phenotype	MP:0003631	8.8	CNP, RB1, BCL2L1, LGALS1, LGALS3, CIC
10	other phenotype	MP:0005395	8.7	KDR, CDKN2A, IL2, HSPG2, CAV1, GJA1
11	hearing/vestibular/ear phenotype	MP:0005377	8.7	RB1, BCL2, BAX, CDKN1A, CDKN1B, ITGB4
12	limbs/digits/tail phenotype	MP:0005371	8.7	RB1, BRCA2, VHL, VEGFA, BAX, CD44
13	immune system phenotype	MP:0005387	8.3	CNP, VIM, BRCA2, RAD54L, KDR, LGALS1
14	adipose tissue phenotype	MP:0005375	8.2	PIK3CA, PDE3B, RB1, BCL2, CDKN1A, CDKN1B
15	skeleton phenotype	MP:0005390	8.0	CNP, RB1, BRCA2, VHL, VEGFA, KDR
16	integument phenotype	MP:0010771	7.9	KLF6, PDE3B, RB1, BRCA2, VHL, BCL2
17	behavior/neurological phenotype	MP:0005386	7.4	PIK3CA, NCAM1, CNP, RB1, VIM, BRCA2
18	reproductive system phenotype	MP:0005389	7.4	PIK3CA, KLF6, CNP, BRCA2, VHL, VEGFA
19	digestive/alimentary phenotype	MP:0005381	7.4	CNP, RB1, BRCA2, VHL, VEGFA, BCL2
20	tumorigenesis	MP:0002006	6.8	PIK3CA, RB1, BRCA2, VHL, BCL2, BCL2L1
21	vision/eye phenotype	MP:0005391	6.7	PIK3CA, NCAM1, CNP, RB1, VIM, VEGFA
22	growth/size phenotype	MP:0005378	6.4	PIK3CA, KLF6, PDE3B, CNP, RB1, BRCA2
23	muscle phenotype	MP:0005369	5.9	PIK3CA, CNP, RB1, VIM, VHL, VEGFA
24	cellular phenotype	MP:0005384	3.5	PIK3CA, KLF6, NCAM1, PCNA, RB1, VIM
25	normal phenotype	MP:0002873	INF	BRCA2, VHL, VEGFA, KDR, LGALS1, MVP
26	renal/urinary system phenotype	MP:0005367	INF	VHL, BCL2, CHGA, BAX, , CDKN1A
27	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, KLF6, RB1, VIM, VHL, VEGFA
28	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, PDE3B, CNP, RB1, VIM, BRCA2
29	mortality/aging	MP:0010768	INF	PIK3CA, KLF6, NCAM1, CNP, RB1, BRCA2

Articles related to oligodendroglioma:

(show top 50)    (show all 138)

id	Title	Authors	Year	Affiliating Genes
1	Caveolin 1 expression independently predicts shorter survival in oligodendrogliomas. (19287309)	Senetta R.... Cassoni P.	2009	CAV1
2	Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival. (18992012)	Holmlund C.... Hedman H.	2009	LRIG2
3	Cyclooxygenase-2 expression in astrocytes and microgl ia in human oligodendroglioma and astrocytoma. (20052522)	Temel S.G.... Kahveci Z.	2009	PTGS1, PTGS2, GFAP
4	IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. (19246647)	Watanabe T.... Ohgaki H.	2009	TP53, IDH1
5	Chromosome 1p and 19q deletions in malignant glioneuronal tumors with oligodendroglioma-like component. (18781279)	Takeuchi H.... Sato K.	2009	TUBB, GFAP, SYP
6	NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas. (19119320)	Benetkiewicz M.... Delattre O.	2009	NOTCH2
7	Platelet-derived growth factor expression correlates with tumor grade and proliferative activity in human oligodendrogliomas. (19559929)	Majumdar K.... Pathak A.	2009	PDGFRA, PDGFRB, PDGFA
8	Occurrence of anaplastic oligodendroglioma in a patie nt with Williams syndrome: a case report with analysis of mutational profile of tumor. (19764675)	Omalu B.I.... Nnebe-Agumadu U.H.	2009	ELN
9	GFAP and alpha1a-AR staining and nuclear morphometry of oligodendrogliomas by confocal microscopy and image analysis: useful parameters for predicting survival in oligodendrogliomas. (18673515)	Moro-RodrA-guez E.... GarcA-a-Poblete E.	2008	GFAP
10	Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? (18685489)	Kuhlmann T.... Bruck W.	2008	RTN4
11	Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. (18492260)	Ducray F.... Sanson M.	2008	EGFR, CDK2, L1CAM
12	Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells. (17160531)	Wharton S.B.... Williams G.H.	2007	MCM2
13	Gene dosage and mutational analyses of EGFR in oligodendrogliomas. (17143531)	Franco-Hernandez C.... Rey J.A.	2007	EGFR
14	Longitudinal assessment of genetic and epigenetic markers in oligodendrogliomas. (17332285)	Lavon I.... Siegal T.	2007	MGMT
15	Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas. (17415208)	Soichi O.... Jun-ichi K.	2007	OLIG2
16	Correlations between O6-methylguanine DNA methyltrans ferase promoter methylation status, 1p and 19q deletions, and response to temoz olomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO stud y. (16954518)	Brandes A.A.... Ermani M.	2006	MGMT
17	Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. (16760646)	Calatozzolo C.... Salmaggi A.	2006	CXCR4, PDGFB
18	Cytologic diagnosis of a metastatic oligodendroglioma in a pleural effusion. A case report. (17017442)	Lee C.C.... Tsai M.D.	2006	OLIG2
19	Gene MGMT and oligodendrogliomas. Fundamental data and short review of the literature (16292171)	Blanc J.L.... Lapierre F.	2005	MGMT
20	Mutational study of the 1p located genes p18ink4c, Pa tched-2, RIZ1 and KIF1B in oligodendrogliomas. (15711769)	Alonso M.E.... Rey J.A.	2005	PRDM2
21	Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (16018821)	Liang Y.... Gupta N.	2005	FABP7, ID4, FAM5C
22	Identification of oligodendroglioma specific chromosomal copy number changes in the glioblastoma MI-4 cell line by array-CGH and FISH analyses. (16102584)	Magnani I.... Larizza L.	2005	CDKN2C
23	Attenuated expression of DFFB is a hallmark of oligodendrogliomas with 1p-allelic loss. (16156899)	McDonald J.M.... Zhang W.	2005	DFFA, DFFB
24	Internalization of exogenous human immunodeficiency virus-1 protein, Tat, by KG-1 oligodendroglioma cells followed by stimulation of DNA replication initiated at the JC virus origin. (15684713)	Daniel D.C.... Johnson E.M.	2004	TAT, PURA
25	Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)	Neder L.... Zago M.A.	2004	LGALS3
26	p53 protein alterations in adult astrocytic tumors and oligodendrogliomas. (15269478)	Nayak A.... Sarkar C.	2004	TP53
27	Genetic determinants of malignancy in a mouse model for oligodendroglioma. (12670909)	Weiss W.A.... Israel M.A.	2003	EGFR
28	Expression of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors in oligodendrogliomas in humans. (12873740)	Fiano V.... Schiffer D.	2003	CDK2
29	Oligodendroglioma: CD44 as a possible prognostic opportunity. (12908752)	Buccoliero A.M.... Taddei G.L.	2003	CD44
30	Analysis of loss of chromosome 10q, DMBT1 homozygous deletions, and PTEN mutations in oligodendrogliomas. (12507139)	Sanson M.... Hoang-Xuan K.	2002	PTEN, DMBT1
31	Oligodendroglioma: pathology and molecular biology. (12453646)	Engelhard H.H.... Cochran E.J.	2002	PCNA, CDKN2A
32	Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. (11800646)	Korshunov A.... Golanov A.	2002	CDK2, CDKN1B, CDKN2A
33	Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line. (12175864)	Huang C.J.... de Vellis J.	2002	TNF, MBP
34	Analysis of the NF2 gene in oligodendrogliomas and ependymomas. (11996787)	Alonso M.E.... Rey J.A.	2002	NF2
35	Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas. (11907807)	Watanabe T.... Ohgaki H.	2002	TP53, MGMT
36	Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas. (11764090)	Watanabe T.... Ohgaki H.	2001	CDK4, TP53, MDM2
37	Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis. (11532161)	Wharton S.B.... Williams G.H.	2001	MCM7
38	PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. (11438483)	Sasaki H.... Louis D.N.	2001	PTEN, DMBT1
39	Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas. (11307615)	Watanabe T.... Ohgaki H.	2001	CDKN2A
40	Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. (11121536)	Deininger M.H.... Schluesener H.J.	2000	PTGS1, CPOX
41	The p73 gene is not mutated in oligodendrogliomas which frequently have a deleted region at chromosome 1p36.3. (10953317)	Tsujimoto T.... Tagawa M.	2000	TP73
42	CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas. (11058870)	Bortolotto S.... Schiffer D.	2000	CDKN2A
43	Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. (10433931)	Bigner S.H.... Bigner D.D.	1999	CDKN2A
44	Immunohistochemical investigation of p53 and EGFR expression of oligodendrogliomas. (10442459)	Broholm H.... Braendstrup O.	1999	EGFR, TP53
45	Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. (9482185)	Di Rocco F.... Black P.M.	1998	PDGFA
46	Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma. (9797000)	Wang Y.... Westphal M.	1998	NTRK1, NTRK2, NTRK3
47	Molecular cloning of IL-2R alpha, IL-2R beta, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: presence of IL-2R mRNAs in the human central nervous system. (8530186)	Otero G.C.... Merrill J.E.	1995	IL2RA
48	Lectins: reliable differentiation markers in human oligodendrogliomas. (8220777)	Figols J.... Cruz-SA!nchez F.F.	1993	GFAP
49	Regulation of phospholipase D activity in a human oligodendroglioma cell line (HOG). (8455209)	Dawson G.... Post G.R.	1993	HSPG2, KNG1
50	Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal. (2395860)	Okamoto Y.... Taniguchi T.	1990	IL2

Genes related to oligodendroglioma according to GeneCards:

(show top 50)    (show all 158)

id	Symbol	Description	Score	GeneCards Section Context
1	GFAP	glial fibrillary acidic protein	11.0	Publications
2	OLIG1	oligodendrocyte transcription factor 1	11.0	Expressions
3	OLIG2	oligodendrocyte lineage transcription factor 2	11.0	Publications, Expressions
4	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0	Publications
5	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
6	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
7	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
8	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
9	CDK4	cyclin-dependent kinase 4	11.0	Publications
10	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0
11	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
12	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
13	PTEN	phosphatase and tensin homolog	11.0	Publications
14	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0
15	EGFR	epidermal growth factor receptor	11.0	Publications
16	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
17	STMN1	stathmin 1	11.0
18	CDK2	cyclin-dependent kinase 2	11.0	Publications
19	TP53	tumor protein p53	11.0	Publications
20	RB1	retinoblastoma 1	11.0	Publications
21	TRIM8	tripartite motif containing 8	11.0
22	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
23	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
24	NKX2-2	NK2 homeobox 2	11.0
25	SOX10	SRY (sex determining region Y)-box 10	11.0
26	GMNN	geminin, DNA replication inhibitor	11.0
27	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
28	SYP	synaptophysin	11.0	Publications
29	MCM7	minichromosome maintenance complex component 7	11.0	Publications
30	UGT8	UDP glycosyltransferase 8	11.0	Publications
31	L1CAM	L1 cell adhesion molecule	11.0	Publications
32	APOD	apolipoprotein D	11.0
33	KLF6	Kruppel-like factor 6	11.0
34	PLP1	proteolipid protein 1	11.0	Publications
35	GLUL	glutamate-ammonia ligase	11.0	Publications
36	CRYAB	crystallin, alpha B	11.0	Publications
37	PRDM2	PR domain containing 2, with ZNF domain	11.0	Publications
38	PDE3B	phosphodiesterase 3B, cGMP-inhibited	11.0	Publications
39	EZR	ezrin	11.0	Publications
40	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0
41	IQGAP1	IQ motif containing GTPase activating protein 1	11.0	Publications
42	CA2	carbonic anhydrase II	11.0
43	DCX	doublecortin	11.0
44	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.0
45	ITGB4	integrin, beta 4	11.0	Publications
46	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
47	MBP	myelin basic protein	11.0	Publications
48	MVP	major vault protein	11.0
49	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
50	MAP2	microtubule-associated protein 2	11.0	Publications

Pathways related to oligodendroglioma according to GeneDecks:

(show top 50)    (show all 151)

id	Pathway	Score	Top Affiliating Genes
1	Glioblastoma Multiforme36	10.9	TSC1, RB1, CDKN1A, CDK2, CDKN1B, CDK4
2	Cell cycle20	10.8	CCNA2, DBF4, CDKN1A, CDKN2B, CDKN1B, MCM7
3	G1-S Phase Transition36	10.8	CDKN2B, CDKN1B, CDKN2A, CDK4, CCNA2, TP53
4	Glioma20	10.8	PTEN, TP53, MDM2, CDK4, CDKN2A, CDKN1A
5	Melanoma20	10.8	CDKN2A, EGFR, EGF, PDGFRB, PDGFRA, PTEN
6	Cyclins and Cell Cycle Regulation36	10.7	RB1, CDKN2A, TP53, CCNA2, CDK4, CDKN1B
7	Pancreatic cancer20	10.6	BRCA2
8	Transcription P53 signaling pathway10	10.6	TP53, CDKN2A, CDK2, VEGFA
9	Cell Cycle / Checkpoint Control3	10.5	GMNN, CDKN2C, TP73, TP53, CCNA2, MCM7
10	Signal transduction_AKT signaling41	10.3	TSC1, PIK3CA, PCNA, BCL2L1, BAX, CDKN1A
11	Transcription_P53 signaling pathway41	10.2	BCL2, TP53, CDKN2A, VEGFA, KDR, CDKN1A
12	Actin-Based Motility by Rho Family GTPases36	10.0	ITGB4, IL2, NTRK1, OGN, ARHGDIA
13	Angiogenesis3	9.9	PTGS2, KDR, VHL, ENG, HMOX1, FLT1
14	Small cell lung cancer20	9.8	CDK2, BCL2L1, BCL2, RB1, PTGS2, CDKN2B
15	Telomerase Components in Cell Signaling36	9.8	PDGFRB, EGFR, IL2, PDGFRA, PDGFB, OGN
16	Selected targets of p5310	9.5	CDKN1A, BCL2, BAX, OGN, CDK2, CDK4
17	Neuroscience3	9.4	NOTCH2, NOS1, NTRK3, NTRK2, NTRK1, PTGS1
18	Bladder cancer20	9.4	EGF, TP53, ERBB2, MDM2, CDK4, CDKN2A
19	Rac1 Pathway36	9.4	PDGFA, ITGB4, IQGAP1, IL2RA, PDGFB, NTRK3
20	PTEN Pathway36	9.4	PTEN, NTRK1, NTRK2, TP53, HSPG2, MDM2
21	Prostate cancer20	9.3	PDGFRA, CDK2, PDGFB, PDGFA, PTEN, TP53
22	ERK5 Signaling36	9.2	FLT1, IL2RA, NTRK1, NTRK2, NTRK3, PDGFB
23	Akt Signaling36	9.2	CXCR4, CXCL1, TNF, NTRK3, PDGFA, PDGFB
24	Breast Cancer Regulation by Stathmin136	9.1	EGF, EGFR, OGN, NTRK3, PDGFB, PDGFA
25	Focal adhesion20	9.1	FLT1, PDGFB, PDGFA, PTEN, ERBB2, PDGFRB
26	Molecular Mechanisms of Cancer36	9.1	CXCL1, SOX10, OGN, TSC1, TP53, PTEN
27	14-3-3 Induced Intracellular Signaling36	9.0	FLT1, OGN, PDGFRB, PDGFB, NTRK3, NTRK2
28	Paxillin Interactions36	8.9	PDGFRB, PDGFB, OGN, EGFR, EGF, PDGFRA
29	Activation of PKC through GPCR36	8.9	PDE3B, KDR, FLT1, IL2, EGF, IL2RA
30	eIF2 Pathway36	8.8	OGN, EGFR, EGF, PDGFRB, PDGFRA, PDGFB
31	PPAR Pathway36	8.8	NTRK3, PPARG, PDGFB, PDGFRA, PDGFRB, EGFR
32	Apoptotic Pathways in Synovial Fibroblasts36	8.8	EGF, FLT1, KDR, OGN, EGFR, PDGFRB
33	ILK Signaling36	8.7	ERBB2, ITGB4, HSPG2, PTGS2, NTRK1, NTRK2
34	p53 Mediated Apoptosis36	8.7	IL2, FLT1, BAX, BCL2, KDR, NTRK3
35	Endothelin-1 Signaling Pathway36	8.7	EDNRB, FLT1, ERBB2, PDGFRA, NTRK1, IL2
36	ERK Signaling36	8.6	ERBB2, HSPG2, CXCL1, NTRK3, PDGFA, PDGFB
37	Mitochondrial Apoptosis36	8.5	BCL2, PDGFB, PDGFA, PDGFRA, PDGFRB, OGN
38	JNK Pathway36	8.5	NTRK3, BCL2, FLT1, BAX, KDR, OGN
39	DHA Signaling36	8.3	NTRK1, PDGFRB, PDGFRA, PDGFB, PDGFA, PLA2G4C
40	eNOS Signaling36	8.3	NTRK3, NOS3, NTRK2, PDGFA, PDGFB, PDGFRA
41	Rho Family GTPases36	8.1	PDGFRB, VIM, KDR, BCL2, ITGB4, FLT1
42	Pathways in cancer20	8.1	EGFR, EGF, PDGFRA, PDGFA, NTRK1, PIK3CA
43	PAK Pathway36	8.1	TNF, PDGFRB, PDGFRA, KDR, BAX, IL2
44	Cellular Apoptosis Pathway36	8.0	OGN, DFFA, KDR, BCL2, NTRK2, NTRK3
45	Pancreatic Adenocarcinoma36	7.6	BCL2L1, OGN, EGFR, EGF, PDGFRB, PDGFRA
46	Antioxidant Action of Vitamin-C36	7.6	EGF, BAX, PLA2G4C, FLT1, IL2, IL2RA
47	MAPK Signaling36	7.4	KDR, PDGFRB, TP53, EGFR, ELN, OGN
48	JAK-STAT Pathway36	7.3	PDGFA, PDGFB, PDGFRA, CXCR4, OGN, EGFR
49	p38 Signaling36	6.9	CXCL1, TNF, NTRK1, PDGFRA, NTRK3, NTRK2
50	Tec Kinases Signaling36	6.7	ITGB4, BCL2, IL2, IL2RA, ERBB2, BAX

Compounds related to oligodendroglioma according to GeneDecks:

(show top 50)    (show all 408)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.9	MVP
2	glucose32	10.5	VHL, LGALS1, FXN, CDK4, MKI67, MGMT
3	h2o232	10.0	BRCA2, BCHE, LGALS3, FTH1, IL2RA, MBP
4	p00332	10.0	RB1, BRCA2, CHGA, MVP, CDKN1B, CD44
5	ceramide32	9.6	PIK3CA, PDE3B, RB1, BCL2L1, LGALS1, UGT8
6	cyclic amp32 18	10.5	KLF6, PDE3B, RB1, CHGA, CDKN1B, CDKN2A
7	calcium32 9 18 9	12.4	PDE3B, RB1, VHL, BCHE, LGALS1, LGALS3
8	atp32	9.4	PIK3CA, NCAM1, PDE3B, RB1, RAD54L, BCL2L1
9	rapamycin32 42	10.2	RB1, VIM, VHL, VEGFA, KDR, LGALS1
10	pge232	9.0	PDE3B, HSPG2, CA2, GJA1, HMOX1, PTGS1
11	agar32	9.0	PIK3CA, RB1, VIM, LGALS1, MTDH, CDK2
12	oligonucleotide32	8.9	PCNA, RB1, VIM, BRCA2, VHL, BCL2
13	glutamine32	8.9	NCAM1, PCNA, VIM, BRCA2, LGALS1, LGALS3
14	forskolin32 42 9 9	11.9	PDE3B, CNP, VIM, CHGA, CDKN1B, FDX1
15	gefitinib32 34 9 9	11.6	PIK3CA, VIM, VEGFA, KDR, BCL2L1, CDKN1A
16	phosphoinositide32	8.6	PIK3CA, PDE3B, VIM, BCL2L1, LGALS3, CDK2
17	superoxide32 18	9.6	PIK3CA, PDE3B, RB1, LGALS1, LGALS3, CDK4
18	etoposide32 42 9 9	11.4	PIK3CA, PCNA, RB1, BCL2, BCL2L1, LGALS1
19	ly29400232	8.3	PIK3CA, VHL, VEGFA, CDKN1B, CD44, CCNA2
20	histamine32 18	9.3	PIK3CA, NCAM1, PDE3B, PCNA, VIM, CHGA
21	carboplatin32 34 9 9	11.3	RB1, VEGFA, KDR, BCL2, CHGA, MSH2
22	glutamate32	8.2	PIK3CA, NCAM1, CNP, PCNA, VIM, KDR
23	flavopiridol32 9 9	10.2	RB1, VEGFA, BCL2, BCL2L1, BAX, CDKN1A
24	matrigel32	8.1	PIK3CA, NCAM1, RB1, VIM, BRCA2, VEGFA
25	lactate32	8.1	PIK3CA, NCAM1, PCNA, VIM, KDR, BCHE
26	adenylate32	8.1	PIK3CA, KLF6, PDE3B, CNP, VIM, CHGA
27	prostacyclin32	8.1	PDE3B, VEGFA, KDR, FLT1, HSPG2, CAV1
28	arginine32	8.1	PIK3CA, BCHE, LGALS1, CHGA, CDK2, CDK4
29	celecoxib32 42 34 9 18 9	13.0	PCNA, VEGFA, KDR, BCL2, BAX, CDKN1A
30	docetaxel32 34 9 9	10.9	BRCA2, VEGFA, KDR, BCL2, BCL2L1, MVP
31	oxygen32 18	8.6	RB1, BCHE, BCL2, BCL2L1, LGALS1, LGALS3
32	doxorubicin32 34 9 9	10.6	PIK3CA, NCAM1, VIM, KDR, BCL2L1, MVP
33	thymidylate32	7.5	PCNA, RB1, VIM, VEGFA, BCL2, BCL2L1
34	curcumin32	7.2	VEGFA, BCL2, BCL2L1, BAX, CDKN1A, CDK2
35	testosterone32 9 18 9	10.2	PIK3CA, NCAM1, PCNA, RB1, VIM, BRCA2
36	5fluorouracil32	7.1	PIK3CA, PCNA, RB1, VEGFA, KDR, BCL2
37	gemcitabine32 34 9 9	10.1	PCNA, VEGFA, KDR, BCL2, BCL2L1, BAX
38	sb 20358032 42	8.1	RB1, VIM, VEGFA, BCL2, BCL2L1, CDKN1A
39	paclitaxel32 34 9 9	9.6	PIK3CA, PCNA, RB1, VIM, BRCA2, VEGFA
40	phosphatidylinositol32	6.6	PIK3CA, NCAM1, PDE3B, RB1, BRCA2, VHL
41	vegf32	6.2	PIK3CA, NCAM1, PCNA, VHL, KDR, BCL2
42	actinomycin d32	5.9	PIK3CA, RB1, VIM, VHL, VEGFA, BCL2
43	cycloheximide32	3.8	VIM, BRCA2, VEGFA, BCL2, BCL2L1, CHGA
44	cisplatin32 34 9 9	INF	PIK3CA, PCNA, RB1, BRCA2, VEGFA, KDR
45	cysteine32	INF	PCNA, KDR, BCL2L1, LGALS1, LGALS3,
46	dexamethasone32 42 34 9 9	INF	PIK3CA, NCAM1, PCNA, RB1, VIM, VEGFA
47	heparin32 9 18 9	INF	PIK3CA, NCAM1, VIM, BCHE, LGALS1, LGALS3
48	alanine32	INF	NCAM1, PCNA, BCHE, LGALS3, , MSH2
49	cholesterol32 9 18 9	INF	PIK3CA, PDE3B, RB1, CHGA, , CDK2
50	cyclosporin a32 42	INF	PIK3CA, MVP, , CDK2, CDK4, CD44

Cellular components related to oligodendroglioma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell leading edge	GO:031252	10.1	VIM, ITGB4, IQGAP1, CXCR4
2	Bcl-2 family protein complex	GO:097136	10.0	MCL1, BAX, BCL2L1
3	nucleoplasm	GO:005654	9.9	MCM7, CCNA2, GMNN, ERCC2, TP53, PPARG
4	protein complex	GO:043234	9.7	RTN4, SYP, TSC1, PTGS2, TP53, CAV1
5	basolateral plasma membrane	GO:016323	9.4	EGFR, PDGFB, ERBB2, AJAP1, CAV1, CA2
6	cell surface	GO:009986	8.7	NTRK1, NTRK2, CRYAB, NOTCH2, PDGFA, PDGFB
7	cytosol	GO:005829	7.9	PLA2G4C, CRYAB, PPARG, NTRK2, PTEN, TP53
8	nucleus	GO:005634	6.9	TP53, TP73, PTEN, PTGS2, PTGS1, OLIG1
9	plasma membrane	GO:005886	6.8	PDGFRA, NF2, NOTCH2, NOS3, CRYAB, NTRK1
10	cytoplasm	GO:005737	6.5	ADRM1, CRYAB, OLIG2, DMBT1, PTGS1, PTGS2
11	extracellular space	GO:005615	INF	TNF, SMPD1, PDGFA, EGF, EGFR, OGN

Biological processes related to oligodendroglioma according to GeneDecks:

(show top 50)    (show all 71)

id	Name	GO ID	Score	Top Affiliating Genes
1	G1 phase of mitotic cell cycle	GO:000080	10.9	CDK4, CDKN2A, CDKN1B, CDKN2B, CDKN2C, CDKN1A
2	positive regulation of fibroblast proliferation	GO:048146	10.9	EGFR, PDGFRA, PDGFB, PDGFA, CDK4, CDKN1A
3	cell cycle checkpoint	GO:000075	10.8	MCM7, ERCC2, TP53, DBF4, MCM2, MDM2
4	negative regulation of phosphorylation	GO:042326	10.8	CDKN2A, CDKN1B, CDKN2B, CDKN2C, CDKN1A
5	axonogenesis	GO:007409	10.7	SLITRK1, SLITRK3, SLITRK2, STMN1, PTPRZ1, MAP2
6	mitotic cell cycle	GO:000278	10.7	MCM2, MCM7, CCNA2, GMNN, TUBB, DBF4
7	cell cycle arrest	GO:007050	10.7	TSC1, NOTCH2, TP73, TP53, CDKN2A, CDKN1B
8	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.7	PDGFRB, PDGFRA, PDGFB, PDGFA, NTRK2, FLT1
9	Ras protein signal transduction	GO:007265	10.6	NTRK1, TP53, CCNA2, CDKN2A, CDK2, CDKN1A
10	mismatch repair	GO:006298	10.6	PMS2, TP73, MSH6, MSH2, PCNA
11	positive regulation of oligodendrocyte differentiation	GO:048714	10.5	NKX2-2, CXCR4, PPARG, OLIG2, TP73
12	S phase of mitotic cell cycle	GO:000084	10.5	MCM7, MCM2, CDK4, CDKN1B, CDK2, CDKN1A
13	negative regulation of platelet activation	GO:010544	10.4	PDGFRA, PDGFB, PDGFA, NOS3
14	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.4	PDGFRB, PDGFRA, FLT1, KDR, VEGFA
15	G1/S transition of mitotic cell cycle	GO:000082	10.4	CDK4, MCM2, MCM7, ID4, DBF4, CDKN2A
16	positive regulation of cell migration	GO:030335	10.4	EGFR, PDGFRB, PDGFRA, PDGFB, PDGFA, FLT1
17	negative regulation of anoikis	GO:2000811	10.3	NTRK2, CAV1, MCL1, PIK3CA
18	oligodendrocyte differentiation	GO:048709	10.2	RTN4, SOX10, NTRK2, CDKN2C, BCL2
19	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	GO:035793	10.1	PDGFA, PDGFB, PDGFRB
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	PDGFRB, PDGFRA, PDGFB, PDGFA, NTRK1, TNF
21	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.1	VEGFA, PDGFRA, PDGFRB
22	negative regulation of cell growth	GO:030308	10.1	RTN4, CRYAB, PPARG, TP53, CDKN2A, CDKN1B
23	release of cytochrome c from mitochondria	GO:001836	10.0	SOD2, TP73, TP53, BAX, BCL2L1, BCL2
24	peptidyl-tyrosine phosphorylation	GO:018108	10.0	EGF, PDGFRB, PDGFRA, PDGFB, FLT1, KDR
25	phosphatidylinositol-mediated signaling	GO:048015	9.9	PDGFRB, PDGFRA, NTRK1, PTEN, ERBB2, MDM2
26	negative regulation of smooth muscle cell proliferation	GO:048662	9.9	OGN, NOS3, PPARG, HMOX1, APOD
27	cellular response to organic cyclic compound	GO:071407	9.8	PPARG, TNF, FDX1, MGMT, CDKN1B, LGALS1
28	cell proliferation	GO:008283	9.7	CXCL1, ELN, EGFR, PTEN, TP53, ERBB2
29	response to estradiol stimulus	GO:032355	9.7	PRDM2, PDGFB, NOS3, CRYAB, PTGS2, IGFBP2
30	induction of apoptosis by intracellular signals	GO:008629	9.7	TP53, CDKN1A, MSH6, BAX, BCL2L1, BCL2
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	PDGFRB, PDGFB, PTGS2, TNF, HMOX1, FLT1
32	regulation of blood pressure	GO:008217	9.6	SOD2, EDNRB, NOS3, PPARG, PTGS1, PTGS2
33	angiogenesis	GO:001525	9.6	RTN4, EGF, PDGFA, NOS3, PTEN, HMOX1
34	induction of apoptosis	GO:006917	9.6	DFFB, DFFA, NOTCH2, PPARG, PTEN, TNF
35	positive regulation of angiogenesis	GO:045766	9.6	NOS3, NTRK1, HMOX1, FLT1, MTDH, KDR
36	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	9.5	ADCYAP1, NTRK3, NTRK2, NTRK1, ERBB2, FLT1
37	negative regulation of cell proliferation	GO:008285	9.4	PTEN, PTGS2, NTRK1, NOS3, NOTCH2, NF2
38	positive regulation of transcription, DNA-dependent	GO:045893	9.3	TP73, TNF, PPARG, PDGFB, EGF, ELF3
39	negative regulation of neuron apoptotic process	GO:043524	9.3	SOD2, NTRK2, NTRK1, HMOX1, GRIN1, MSH2
40	negative regulation of apoptotic process	GO:043066	9.2	ERCC2, TP53, TNF, PTEN, EGFR, DFFA
41	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.2	TNF, CAV1, CD44, BCL2, VEGFA, PIK3CA
42	nervous system development	GO:007399	9.0	NOTCH2, EDNRB, PURA, DCX, CXCL1, SMPD1
43	positive regulation of cell proliferation	GO:008284	9.0	NTRK2, PDGFA, PDGFB, PDGFRA, PDGFRB, EGF
44	positive regulation of apoptotic process	GO:043065	8.9	ADCY10, ADRB2, KNG1, NOS3, SMPD1, PTGS2
45	positive regulation of MAP kinase activity	GO:043406	8.8	EGFR, EGF, PDGFRB, PDGFB, PDGFA, TNF
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	TP73, TNF, PPARG, NOS1, ELF3, SOX10
47	response to drug	GO:042493	8.7	RAD54L, IGFBP2, CAV1, TNF, PTGS2, PPARG
48	response to hypoxia	GO:001666	8.6	CRYAB, NOS1, NOS3, PDGFB, CXCR4, TNF
49	anti-apoptosis	GO:006916	8.4	HMOX1, TNF, CRYAB, NOS3, NOTCH2, GLO1
50	apoptotic process	GO:006915	8.4	TP53, TNF, PTEN, ACTC1, DFFA, DFFB

Molecular functions related to oligodendroglioma according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor-activated receptor activity	GO:005021	10.7	PDGFRB, PDGFRA, FLT1, KDR
2	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.7	CDKN2A, CDKN1B, CDKN2B, CDKN2C, CDKN1A
3	platelet-derived growth factor binding	GO:048407	10.5	PDGFRB, PDGFRA, PDGFB, PDGFA
4	protein kinase binding	GO:019901	10.3	DCX, PTEN, TP73, TP53, CCNA2, IQGAP1
5	platelet-derived growth factor receptor binding	GO:005161	10.3	PDGFRB, PDGFRA, PDGFB, PDGFA, VEGFA
6	vascular endothelial growth factor binding	GO:038085	10.3	PDGFRB, PDGFRA, KDR
7	MutLalpha complex binding	GO:032405	10.2	PCNA, MSH2, MSH6
8	single-stranded DNA binding	GO:003697	10.1	PMS2, PURA, MCM7, MLH1, FUBP1, MSH2
9	neurotrophin binding	GO:043121	9.9	NTRK3, NTRK2, NTRK1
10	enzyme binding	GO:019899	9.8	TP53, PTEN, PTGS2, PPARG, EGFR, DFFB
11	BH3 domain binding	GO:051434	9.7	BCL2, BCL2L1, BAX, MCL1
12	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.7	EGFR, PDGFRA, NTRK3, NTRK1, ERBB2, FLT1
13	protease binding	GO:002020	9.4	ADRM1, TNF, TP53, MBP, BCL2, BRCA2
14	identical protein binding	GO:042802	8.6	TRIM8, TP53, TP73, TNF, EGFR, SYP
15	ATP binding	GO:005524	8.6	ERCC2, ERBB2, TP53, NTRK1, NTRK2, NTRK3
16	protein homodimerization activity	GO:042803	8.4	OLIG2, NTRK1, NTRK2, CRYAB, PDGFA, PDGFB
17	protein binding	GO:005515	4.5	CCNA2, TP53, TP73, TNF, PTEN, DMBT1