MCID: OLG002
MIFTS: 67

Oligodendroglioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Oligodendroglioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the... more...

MalaCards: Oligodendroglioma, also known as oligodendroglial neoplasm, is related to astrocytoma and dysembryoplastic neuroepithelial tumor. An important gene associated with Oligodendroglioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Rho Family GTPases and Pathways in cancer. The compounds retinoic acid and vegf have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and endothelial, and related mouse phenotypes are mortality/aging and immune system.

Aliases & Classifications for Oligodendroglioma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
oligodendroglioma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

oligodendroglioma 8 42 22 10 44 48 60
oligodendroglial neoplasm 8 60
oligodendroglial tumors 44
oligodendroglial tumor 8
oligodendroglioma nos 8


External Ids:

Disease Ontology8 DOID:3181
MeSH34 D009837
NCIt39 C3288
SNOMED-CT via Orphanet57 443936004, 73348003

Related Diseases for Oligodendroglioma

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17GeneCards, 18GeneDecks
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Diseases in the Oligodendroglioma family:

Adult Oligodendroglioma

Diseases related to Oligodendroglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.9TP53, LGALS3, PTEN, KDR, GFAP, OLIG2
2dysembryoplastic neuroepithelial tumor30.5OLIG2
3anaplastic oligodendroglioma30.4LGALS3, PTEN, KDR, GFAP, OLIG2, OLIG1
4central neurocytoma30.3GFAP, OLIG2
5leukemia30.2TP53, KDR, OLIG2, CDKN2C, CDK2, CDK4
6brain cancer30.1EGFR, MDM2, MGMT
7sarcoma30.0TP53, KDR, CDK2, CDK4, RB1, STMN1
8meningioma30.0PTEN, GFAP, CDKN2C, CDKN2B
9acute leukemia30.0CDKN2C, CDKN2B, IGFBP2, STMN1
10neuroblastoma30.0TP53
11oligoastrocytoma30.0GFAP, MGMT
12mixed glioma30.0GFAP, PDGFRA
13melanoma29.8TP53, LGALS3, PTEN, KDR, CDKN2C, CDK2
14glioblastoma multiforme29.8TP53, PTEN, KDR, GFAP, CDK4, CDKN2B
15breast cancer29.8TP53, LGALS3, PTEN, KDR, CDKN2C, CDK2
16adenoma29.8TP53, LGALS3, CDKN2C, CDK2, CDK4, CDKN2A
17medulloblastoma29.8TP53, GFAP, CDK4, CDKN2B, STMN1, DMBT1
18pituitary adenoma29.8LGALS3, CDK4, CDKN2B, RB1, MGMT
19rhabdomyosarcoma29.8TP53, CDK4, RB1, MDM2, PDGFRA
20gliosarcoma29.8PTEN, GFAP, CDK4
21neurofibromatosis29.8PDGFRA
22meningitis29.8IGFBP2
23lynch syndrome29.8TP53
24non-hodgkin lymphoma29.8CDKN2C, CDKN2B, STMN1, MDM2
25brain oligodendroglioma10.5
26spinal cord oligodendroglioma10.5
27cerebritis10.5
28adult oligodendroglioma10.4
29childhood oligodendroglioma10.3
30mixed oligodendroglioma-astrocytoma10.2
31neuronitis10.2
32multiple sclerosis10.2
33clear cell ependymoma10.2
34arteriovenous malformation10.1
35ovarian cystic teratoma10.1
36mixed astrocytoma-ependymoma-oligodendroglioma10.1
37cystic teratoma10.1
38mature teratoma10.1
39glomerulosclerosis, focal segmental, 610.1
40granular cell tumor10.1
41cerebral angioma10.0
42brain sarcoma10.0
43pleomorphic xanthoastrocytoma10.0
44cervicitis10.0
45anaplastic astrocytoma10.0TP53, LGALS3, PTEN, GFAP, OLIG2, OLIG1
46squamous cell carcinoma10.0TP53, LGALS3, PTEN, KDR, CDK2, CDK4
47adenocarcinoma10.0TP53, LGALS3, PTEN, KDR, CDK2, CDK4
48malignant glioma10.0TP53, PTEN, KDR, GFAP, OLIG2, CDK4
49hepatocellular carcinoma10.0TP53, PTEN, KDR, CDKN2C, CDK2, CDK4
50ovarian cancer10.0TP53, PTEN, KDR, CDKN2C, CDK2, CDK4

Graphical network of the top 20 diseases related to Oligodendroglioma:



Diseases related to oligodendroglioma

Clinical Features for Oligodendroglioma

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Drugs & Therapeutics for Oligodendroglioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oligodendroglioma

Drug clinical trials:

Search ClinicalTrials for Oligodendroglioma

Search NIH Clinical Center for Oligodendroglioma

Search CenterWatch for Oligodendroglioma

Genetic Tests for Oligodendroglioma

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22GTR
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Genetic tests related to Oligodendroglioma:

id Genetic test Affiliating Genes
1 Oligodendroglioma22

Anatomical Context for Oligodendroglioma

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32MalaCards
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MalaCards organs/tissues related to Oligodendroglioma:

32
Brain, Spinal cord, Endothelial, Bone, Bone marrow, Temporal lobe, Breast, Parietal lobe, Pineal, Pituitary, B cells, Myeloid, Cerebellum, Tongue, Medulla oblongata

Animal Models for Oligodendroglioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oligodendroglioma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.6CDKN2B, CDKN2A, EGFR, RB1, DMBT1, MDM2
2MP:000538711.5CDKN2A, IGFBP2, EGFR, RB1, DMBT1, MDM2
3MP:000538411.5CDKN2B, CDKN2A, EGFR, RB1, DMBT1, MDM2
4MP:000200611.4TP53, PDGFRA, MGMT, MDM2, DMBT1, RB1
5MP:000538511.4IGFBP2, EGFR, RB1, STMN1, MDM2, PDGFRA
6MP:000539711.4CDKN2A, IGFBP2, EGFR, RB1, MDM2, PDGFRA
7MP:000537811.3CDK4, CDKN2A, EGFR, RB1, MDM2, PDGFRA
8MP:000536911.3PDGFRA, MDM2, STMN1, RB1, CDKN2A, CDK4
9MP:001077111.3PDGFRA, MDM2, RB1, CDKN2A, CDKN2B, CDK4
10MP:000538111.2RB1, DMBT1, MDM2, PDGFRA, EGFR, CDKN2A
11MP:000537011.1MDM2, RB1, EGFR, IGFBP2, CDKN2A, CDK4
12MP:000537611.1PDGFRA, MGMT, DMBT1, STMN1, CDK4, CDKN2C
13MP:000301211.1MGMT, MDM2, RB1, EGFR, CDKN2A, CDKN2B
14MP:000538911.1PDGFRA, EGFR, CDKN2A, CDKN2B, CDK2, CDKN2C
15MP:000537911.1PDGFRA, MGMT, RB1, CDKN2A, CDKN2B, CDK4
16MP:000363111.0CDK4, OLIG1, OLIG2, GFAP, LGALS3
17MP:000538811.0TP53, PDGFRA, RB1, EGFR, CDKN2C, OLIG2
18MP:000536710.9LGALS3, EGFR, DMBT1
19MP:000287310.8PDGFRA, MDM2, STMN1, RB1, EGFR, IGFBP2
20MP:000538210.7MDM2, RB1, EGFR, PTEN, TP53, PDGFRA
21MP:000538010.7DMBT1
22MP:000539010.6PDGFRA, RB1, OLIG2, LGALS3
23MP:000538610.6CDKN2A, RB1, MDM2, PDGFRA, CDK4, CDKN2C
24MP:000539110.6GFAP, EGFR

Publications for Oligodendroglioma

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50PubMed
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Articles related to Oligodendroglioma:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Pitfalls of conservative treatments of multiple probable cerebral cavernous malformations (CCMs): clinicopathological features of CCMs coexisting with vasculogenic mimicry in an anaplastic oligodendroglioma. (24337536)
2013
2
Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012. (24100794)
2013
3
A case of pediatric optic pathway oligodendroglioma presenting widespread invasion and dissemination in the cerebrospinal fluid. (23996461)
2013
4
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. (23527265)
2013
5
Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis. (23885787)
2013
6
Diagnosis of oligodendroglioma: molecular and classical histological assessment in the twenty-first century. (22897886)
2012
7
Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature. (22496515)
2012
8
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. (22102956)
2011
9
Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes. (21842121)
2011
10
Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma. (20556480)
2011
11
Oligodendroglioma cell lines containing t(1;19)(q10;p10). (20388696)
2010
12
Assessment of tumor angiogenesis as a prognostic factor of survival in patients with oligodendroglioma. (19618120)
2010
13
Low-grade oligodendroglioma: current treatments and future hopes. (19895248)
2009
14
NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas. (19119320)
2009
15
Collision tumor of anaplastic oligodendroglioma and gangliocytoma: a case report. (19856221)
2009
16
Complete Radiologic Response in an Anaplastic Oligodendroglioma Treated with Temozolomide and Bevacizumab. (20740146)
2009
17
Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? (18685489)
2008
18
Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression. (17653765)
2008
19
Immunohistochemical evaluation of the microvascular density through the expression of TGF-beta (CD 105/endoglin) and CD 34 receptors and expression of the vascular endothelial growth factor (VEGF) in oligodendrogliomas. (18181830)
2008
20
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)
2007
21
Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells. (17160531)
2007
22
Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas. (17415208)
2007
23
The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making. (16619658)
2006
24
Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy. (16084959)
2005
25
Challenging diagnosis: oligodendroglioma versus extraventricular neurocytoma. (16167546)
2005
26
Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas. (15711769)
2005
27
Oligodendroglioma. (15967093)
2005
28
Oligodendroglioma and multiple sclerosis. A case report. (15368029)
2004
29
Diagnosis and management of oligodendroglioma. (15497117)
2004
30
Tumour necrosis and microvascular proliferation are associated with 9p deletion and CDKN2A alterations in 1p/19q-deleted oligodendrogliomas. (14507338)
2003
31
Current diagnosis and treatment of oligodendroglioma. (16212319)
2002
32
Oligodendroglioma: clinical profile and treatment results. (12577096)
2002
33
Analysis of loss of chromosome 10q, DMBT1 homozygous deletions, and PTEN mutations in oligodendrogliomas. (12507139)
2002
34
Varied persistent life cycles of Borna disease virus in a human oligodendroglioma cell line. (11907227)
2002
35
Hemihyperaesthesia and hyperresponsiveness resembling central pain syndrome in a dog with a forebrain oligodendroglioma. (11098380)
2000
36
CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas. (11058870)
2000
37
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma. (10344289)
1999
38
The prognostic role of vessel productive changes and vessel density in oligodendroglioma. (10619493)
1999
39
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. (9236838)
1997
40
Mesial temporal dysembryoplastic neuroepithelial tumor mimicking oligodendroglioma: a case report and review of the literature. (9041772)
1996
41
Oligodendroglioma. (8630687)
1996
42
Molecular cloning of IL-2R alpha, IL-2R beta, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: presence of IL-2R mRNAs in the human central nervous system. (8530186)
1995
43
Chemotherapy for oligodendroglioma. Progress report. (1993014)
1991
44
Oligodendroglioma--a case presentation. (2308753)
1990
45
Multiple oligodendroglioma--case report. (1695334)
1990
46
Oligodendroglioma. An analysis of the value of radiation therapy. (3440228)
1987
47
Primary oligodendroglioma of the septum pellucidum. (3614609)
1987
48
Cystic oligodendroglioma. (6535775)
1984
49
An oligodendroglioma in a bull. (7434545)
1980
50
An unusual presentation of an oligodendroglioma. Case report. (7420181)
1980

Genetic Variations for Oligodendroglioma

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Expression for genes affiliated with Oligodendroglioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligodendroglioma

Search GEO for disease gene expression data for Oligodendroglioma.

Pathways for genes affiliated with Oligodendroglioma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 55SinoBiological, 59Tocris Bioscience
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Pathways related to Oligodendroglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1MDM2, PDGFRA, STMN1, RB1, TP53, PTEN
210.9PDGFRA, MDM2, RB1, EGFR, CDKN2A, CDKN2B
310.9PDGFRA, MGMT, MDM2, RB1, EGFR, CDKN2A
410.8PDGFRA, MDM2, STMN1, EGFR, CDKN2B, CDK4
5
Hide members
10.8PDGFRA, MDM2, RB1, EGFR, CDKN2A, KDR
610.8PDGFRA, MDM2, EGFR, CDK4, CDK2, KDR
710.8TP53, PTEN, KDR, CDK2, CDK4, EGFR
810.8PDGFRA, RB1, CDKN2A, CDKN2B, CDK4, CDKN2C
9
Hide members
10.8MDM2, RB1, CDKN2A, CDKN2B, CDK4, CDK2
10
Hide members
10.8MGMT, MDM2, RB1, CDKN2A, CDK4, CDK2
11
Hide members
10.8RB1, CDKN2A, CDKN2B, CDK4, CDK2, CDKN2C
12
Hide members
10.8TP53, CDKN2C, CDK2, CDKN2B, RB1, MDM2
1310.8RB1, EGFR, CDK4, CDK2, GFAP, LGALS3
1410.8PDGFRA, MDM2, STMN1, EGFR, CDKN2A, PTEN
1510.8MDM2, RB1, CDKN2A, CDKN2B, CDK4, CDK2
16
Hide members
10.8MDM2, RB1, CDKN2A, CDK4, CDK2, PTEN
17
Transcription P53 signaling pathway
Hide members
10.8MDM2, RB1, CDKN2A, CDK4, CDK2, KDR
1810.8MDM2, RB1, EGFR, CDK4, CDK2, PTEN
19
Hide members
10.7PDGFRA, MDM2, EGFR, KDR, PTEN, TP53
20
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10.7PDGFRA, MDM2, EGFR, KDR, PTEN, TP53
21
Hide members
10.7PDGFRA, STMN1, CDKN2B, CDK4, CDK2, TP53
22
Hide members
10.7MDM2, RB1, EGFR, CDKN2A, CDK4, TP53
2310.7RB1, CDKN2B, CDK4, CDK2, PTEN, TP53
24
Hide members
10.7MDM2, RB1, CDKN2A, CDK2, CDKN2C, TP53
25
Hide members
10.7MDM2, RB1, CDK4, CDK2, PTEN, TP53
26
Hide members
10.7PDGFRA, MDM2, EGFR, GFAP, PTEN
27
Cell cycle Cell cycle (generic schema)
Hide members
10.7RB1, CDKN2A, CDKN2B, CDK4, CDK2
28
Hide members
10.7PTEN, KDR, EGFR, RB1, PDGFRA
29
Hide members
10.7MGMT, MDM2, RB1, CDK4, CDK2
3010.7MDM2, RB1, CDKN2A, PTEN, TP53
31
Hide members
10.7MDM2, RB1, CDK4, CDK2, PTEN
3210.7TP53, PTEN, EGFR, RB1, MDM2
33
Hide members
10.7RB1, CDK4, CDK2, PTEN, TP53
34
Hide members
10.6MDM2, CDKN2A, PTEN, TP53
35
Hide members
10.6MDM2, EGFR, PTEN, TP53
3610.6PTEN, EGFR, RB1, MDM2
3710.6MGMT, CDK4, CDK2, TP53
3810.6MDM2, RB1, CDKN2A, TP53
3910.6TP53, CDK2, CDK4, MDM2
40
Hide members
10.6PTEN, CDK2, CDK4, RB1
41
Hide members
10.6MDM2, IGFBP2, PTEN, TP53
42
Hide members
10.6KDR, MDM2, PDGFRA
4310.6TP53, CDKN2A, MDM2
4410.6TP53, CDKN2A, MDM2
4510.6TP53, CDK2, CDK4
4610.6CDK2, CDK4, RB1
4710.6MDM2, CDK2, TP53
4810.6KDR, CDK2, RB1
4910.6RB1, CDK2
5010.6RB1, CDK2

Compounds for genes affiliated with Oligodendroglioma

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44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Oligodendroglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.6CDKN2A, PTEN, KDR, GFAP, OLIG2, IGFBP2
2vegf4411.5TP53, LGALS3, KDR, GFAP, CDK2, CDK4
3cisplatin44 49 59 1114.5CDK2, GFAP, KDR, PTEN, LGALS3, TP53
4progesterone44 59 28 11 2415.5CDK2, CDK4, CDKN2A, IGFBP2, EGFR, STMN1
5tyrosine4411.4PTEN, LGALS3, IGFBP2, EGFR, RB1, STMN1
6paclitaxel44 49 1113.4CDK2, GFAP, KDR, PTEN, MDM2, STMN1
7doxorubicin44 49 1113.4MGMT, MDM2, STMN1, RB1, EGFR, CDKN2A
8thymidine44 2412.4KDR, PDGFRA, MGMT, STMN1, IGFBP2, CDK4
9oligonucleotide4411.3PDGFRA, TP53, PTEN, CDK4, IGFBP2, RB1
10threonine4411.3CDKN2A, RB1, STMN1, CDK2, MDM2, PTEN
115fluorouracil4411.3CDKN2A, CDK4, CDK2, KDR, PTEN, TP53
12agar4411.3LGALS3, RB1, PTEN, EGFR, CDKN2A, GFAP
13genistein44 28 59 2 11 2416.3MDM2, KDR, MGMT, RB1, CDKN2A, GFAP
14paraffin4411.3MGMT, MDM2, EGFR, CDK4, GFAP, KDR
15arginine4411.2CDKN2A, IGFBP2, MDM2, CDK4, GFAP, TP53
16pd 98,0594411.2GFAP, PTEN, CDKN2B, EGFR, CDK2, RB1
17rapamycin4411.2CDK2, KDR, PTEN, IGFBP2, EGFR, RB1
18phosphatidylinositol4411.2EGFR, IGFBP2, RB1, CDK4, MDM2, PDGFRA
19ly2940024411.2KDR, TP53, PTEN, MDM2, CDK2, CDK4
20thymidylate4411.2EGFR, RB1, CDKN2A, CDK4, CDK2, TP53
21camptothecin44 59 1113.2TP53, KDR, CDK2, RB1, MGMT, MDM2
22flavopiridol44 1112.2MDM2, RB1, EGFR, CDKN2A, CDK4, CDK2
23carboplatin44 49 1113.2CDK4, RB1, TP53, MDM2, MGMT, EGFR
24oxygen44 2412.1IGFBP2, GFAP, LGALS3, CDK4, CDKN2A, RB1
25testosterone44 59 11 2414.1EGFR, CDK2, IGFBP2, RB1, MDM2, PTEN
26mg 13244 5912.1PTEN, KDR, TP53, CDKN2A, EGFR, CDK2
27serine4411.1GFAP, CDKN2C, CDKN2B, STMN1, DMBT1
28cysteine4411.1LGALS3, CDK4, GFAP, CDKN2A, RB1, KDR
29roscovitine4411.1CDK2, CDK4, CDKN2A, TP53, RB1, MDM2
30trastuzumab44 49 1113.1PTEN, CDK2, CDK4, EGFR, MDM2, KDR
31gefitinib44 49 1113.1EGFR, PTEN, KDR, CDK2, CDK4, MDM2
32olomoucine44 1112.1TP53, CDK2, CDK4, CDKN2A, RB1
33calcium44 49 11 2414.0CDK4, IGFBP2, STMN1, LGALS3, GFAP, DMBT1
34bcnu4411.0GFAP, TP53, MGMT, CDKN2A, EGFR
35adpribose4411.0MDM2, CDK4, TP53, RB1, CDK2, EGFR
36geldanamycin44 49 59 1114.0MDM2, EGFR, KDR, CDK4, TP53, CDK2
37cytarabine44 49 1113.0TP53, CDK2, GFAP, CDKN2B, CDKN2A, RB1
38crcs4411.0CDKN2A, MGMT, TP53, RB1, PTEN
39dexamethasone44 49 28 1114.0RB1, MGMT, MDM2, KDR, CDK2, CDKN2A
40estrogen4411.0GFAP
41etoposide44 49 59 1113.9CDK2, RB1, LGALS3, MDM2
42nitric oxide44 11 2412.9MGMT, CDKN2A, CDK4, CDK2, KDR, PTEN
43cycloheximide4410.8IGFBP2
44tgf beta14410.8CDK4, KDR, CDK2, CDKN2B, PDGFRA, PTEN
45vincristine44 49 1112.8MGMT, RB1
46cyclophosphamide44 49 1112.8PTEN, TP53, MDM2, KDR, RB1, MGMT
47butyrate4410.7GFAP, CDK2
48imatinib44 49 1112.6PTEN, EGFR, MDM2, PDGFRA, CDK2, KDR
49fascaplysin4410.6CDK2, CDK4, CDKN2A
50curcumin4410.4CDK2, MGMT, TP53, MDM2, CDK4, EGFR

GO Terms for genes affiliated with Oligodendroglioma

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16Gene Ontology
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Cellular components related to Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3TP53, PDGFRA, MGMT, MDM2, RB1, EGFR
2cytoplasmGO:00573711.2PDGFRA, MDM2, DMBT1, EGFR, CDKN2A, CDKN2B
3cytosolGO:00582911.0MDM2, STMN1, CDKN2A, CDKN2B, CDK4, CDK2
4nucleoplasmGO:00565410.8MGMT, MDM2, RB1, CDKN2A, CDK4, CDK2
5nuclear bodyGO:01660410.7MDM2, CDKN2A, TP53
6PML bodyGO:01660510.6TP53, PTEN, RB1
7chromatinGO:00078510.5RB1, CDK4, TP53
8cyclin-dependent protein kinase holoenzyme complexGO:00030710.3CDK2, CDK4

Biological processes related to Oligodendroglioma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.1PTEN, KDR, CDK2, CDK4, EGFR, MDM2
2mitotic cell cycleGO:00027811.1RB1, CDKN2A, CDKN2B, CDK4, CDK2, CDKN2C
3modulation by virus of host morphology or physiologyGO:01904811.1PDGFRA, MDM2, DMBT1, RB1, KDR, TP53
4cell cycle arrestGO:00705011.0RB1, CDKN2A, CDKN2B, CDKN2C, TP53
5innate immune responseGO:04508711.0PDGFRA, MDM2, DMBT1, EGFR, PTEN, LGALS3
6negative regulation of cell proliferationGO:00828511.0CDKN2A, CDKN2B, CDKN2C, PTEN, TP53
7Ras protein signal transductionGO:00726511.0RB1, CDKN2A, CDK2, TP53
8phosphatidylinositol-mediated signalingGO:04801511.0PDGFRA, MDM2, EGFR, PTEN
9negative regulation of phosphorylationGO:04232610.9CDKN2A, CDKN2B, CDKN2C
10negative regulation of G1/S transition of mitotic cell cycleGO:200013410.9PTEN, CDKN2B, RB1
11fibroblast growth factor receptor signaling pathwayGO:00854310.9PDGFRA, MDM2, EGFR, PTEN
12positive regulation of fibroblast proliferationGO:04814610.9CDK4, EGFR, PDGFRA
13Fc-epsilon receptor signaling pathwayGO:03809510.9PTEN, EGFR, MDM2, PDGFRA
14negative regulation of epithelial cell proliferationGO:05068010.9PTEN, CDKN2B, RB1
15regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.8CDKN2B, CDKN2C, PTEN
16epidermal growth factor receptor signaling pathwayGO:00717310.8PDGFRA, MDM2, EGFR, PTEN
17negative regulation of apoptotic processGO:04306610.8TP53, PTEN, KDR, EGFR, MDM2
18DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.7MDM2, CDK2, TP53
19positive regulation of epithelial cell differentiationGO:03085810.7CDKN2B, DMBT1
20mitotic G1 DNA damage checkpointGO:03157110.6CDK2, TP53
21positive regulation of ERK1 and ERK2 cascadeGO:07037410.6KDR, EGFR, PDGFRA
22replicative senescenceGO:09039910.6TP53, CDKN2A
23response to drugGO:04249310.5MGMT, MDM2, IGFBP2, CDK4
24neurotrophin TRK receptor signaling pathwayGO:04801110.3PTEN, EGFR, MDM2, PDGFRA

Molecular functions related to Oligodendroglioma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4TP53, PDGFRA, MDM2, DMBT1, RB1, EGFR
2protein kinase bindingGO:01990110.9CDKN2A, CDKN2B, CDKN2C, PTEN, TP53
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.8CDKN2C, CDKN2B, CDKN2A
4transmembrane receptor protein tyrosine kinase activityGO:00471410.8KDR, EGFR, PDGFRA
5vascular endothelial growth factor bindingGO:03808510.7PDGFRA, KDR
6MDM2/MDM4 family protein bindingGO:09737110.6TP53, CDKN2A
7p53 bindingGO:00203910.6MDM2, CDKN2A, TP53
8receptor signaling protein tyrosine kinase activityGO:00471610.6KDR, EGFR
9vascular endothelial growth factor-activated receptor activityGO:00502110.5KDR, PDGFRA
10enzyme bindingGO:01989910.3TP53, PTEN, EGFR, MDM2

Products for genes affiliated with Oligodendroglioma

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Sources for Oligodendroglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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