Oligohydramnios disease: drugs, articles, genes, clinical trials

Summaries for Oligohydramnios

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⁶Disease Ontology, ⁴⁴Wikipedia, ²²MalaCards
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Disease Ontology: A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.⁶

MalaCards: Oligohydramnios, also known as oligohydramnios - delivered (disorder), is related to twin-to-twin transfusion syndrome and twin twin transfusion syndrome. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Highly sodium permeable acetylcholine nicotinic receptors and ACE Inhibitor Pathway, Pharmacodynamics. The compounds glucose and remikiren have been mentioned in the context of this disorder. Affiliated tissues include brain, placenta and fetal brain, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Wikipedia: Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the...⁴⁴ more...

Aliases & Descriptions for Oligohydramnios

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⁶Disease Ontology, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ⁴⁰SNOMED-CT, ²⁴MeSH, ¹⁹ICD9CM
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Aliases & Descriptions:

oligohydramnios ⁶ ⁸ ³² ⁴³

oligohydramnios - delivered (disorder) ⁶

oligohydramnios - delivered ⁴³

oligohydramnios, antepartum ⁴³

antepartum oligohydramnios ⁶

delivered oligohydramnios ⁶

External Ids:

MeSH²⁴ D016104

SNOMED-CT⁴⁰ 59566000, 199652007, 157051001 199656005, 156190009, more

ICD9CM¹⁹ 658.0

UMLS⁴³ C0079924

Related Diseases for Oligohydramnios

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¹³GeneCards, ¹⁴GeneDecks
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Diseases related to oligohydramnios by text searches and GeneDecks gene sharing:

(show top 50) (show all 213)

id	Related Disease	Score	Top Affiliating Genes
1	twin-to-twin transfusion syndrome	26.5	REN, ASPRV1, EDN1, AFP
2	twin twin transfusion syndrome	26.5	REN, ASPRV1, EDN1, AFP
3	renal tubular dysgenesis	26.3	REN, ACE, AGT, AGTR1
4	polyhydramnios	25.5	ASPRV1, AQP1, AQP3, AQP8, EDN1, OXT
5	twinning	23.7	REN, CGA, ASPRV1, EDN1, ACE, OXT
6	multiple pterygium syndrome lethal type	13.6	CHRND, CHRNG
7	fetal akinesia deformation sequence	13.5	CHRND, CHRNG
8	multiple pterygium syndrome escobar type	13.5	CHRND, CHRNG
9	cystic lymphangioma	13.5	CHRND, AFP, CHRNG
10	lymphangioma	13.5	CHRND, AFP, CHRNG
11	ovarian mixed germ cell neoplasm	13.4	CGA, AFP
12	polyembryoma	13.4	CGA, AFP
13	asphyxia neonatorum	13.4	NAGLU, OXT, ADM
14	borderline personality disorder	13.2	CGA, SPAG5, OXT
15	nonseminomatous germ cell tumor	13.2	CGA, AFP
16	edwards syndrome	13.1	CGA, PRUNE, AFP
17	mature teratoma	13.1	CGA, AFP
18	placental abruption	13.1	SERPINH1, AGT, AFP
19	functioning pituitary adenoma	13.0	CGA, GPR182, ADM
20	cutis marmorata telangiectatica congenita	13.0	CGA, AFP
21	ovarian cyst	13.0	CGA, ADM, AFP
22	endodermal sinus tumor	13.0	CGA, AFP
23	acute pyelonephritis	13.0	NAGLU, ACE, ADM
24	focal segmental glomerulosclerosis	12.9	NAGLU, ACE, AGTR1
25	amenorrhea	12.8	CGA, OXT, NPPB, AFP
26	hydrocephalus	12.8	ASPRV1, AQP1, ACE, AFP
27	hyporeninemic hypoaldosteronism	12.8	REN, ACE
28	posterior urethral valves	12.8	ACE, AGT, AGTR1
29	mitral valve disease	12.8	ACE, AGT, AGTR1
30	catecholaminergic polymorphic ventricular tachycardia	12.8	ACE, OXT, NPPB
31	abcb11-related intrahepatic cholestasis	12.8	REN, OXT, NPPB
32	ischemic optic neuropathy	12.7	ACE, AGT, AGTR1
33	pyelonephritis	12.7	NAGLU, ACE, PRUNE, ADM
34	nephrosclerosis	12.7	ACE, AGTR1, ADM
35	21-hydroxylase deficiency	12.7	REN, AGTR1, AFP
36	diabetes, type 2	12.7	ACE, AGT, AGTR1
37	raynaud disease	12.7	EDN1, AGTR1
38	diabetic angiopathy	12.7	NAGLU, EDN1, ADM
39	membranous glomerulonephritis	12.7	ACE, AGT, AGTR1
40	otosclerosis	12.7	ACE, AGT, AGTR1
41	postural orthostatic tachycardia syndrome	12.7	REN, AGT, AGTR1
42	conn's syndrome	12.7	REN, AGTR1
43	neurocirculatory asthenia	12.6	ACE, AGT, AGTR1
44	endometritis	12.6	SERPINH1, CGA, ACE, OXT
45	hypoaldosteronism	12.6	REN, ACE
46	enuresis	12.6	REN, NPPB, ADM
47	choriocarcinoma	12.6	CGA, GPR182, OXT, ADM, AFP
48	retinal disease	12.6	NAGLU, ACE, AGT, ADM
49	malignant hypertension	12.6	REN, ACE, ADM
50	pre-eclampsia	12.6	EDN1, AGT

Graphical network of the top 20 diseases related to oligohydramnios:

Graphical network of diseases related to oligohydramnios

Clinical Features for Oligohydramnios

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Drugs & Therapeutics for Oligohydramnios

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

Search CenterWatch for oligohydramnios

Drug clinical trials:

Search ClinicalTrials for oligohydramnios

Search NIH Clinical Center for oligohydramnios

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Genetic Tests for Oligohydramnios

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Anatomical Context for Oligohydramnios

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²²MalaCards
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MalaCards organs/tissues related to oligohydramnios:

²²

Brain, Placenta, Fetal brain

Phenotypes for genes affiliated with Oligohydramnios

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²⁵MGI
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MGI Mouse Phenotypes related to oligohydramnios:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	5.7	REN, ADM, OXT, AGTR1, AGT, ACE
2	cardiovascular system phenotype	MP:0005385	5.6	ADM, NPPB, OXT, AGTR1, AGT, ACE
3	mortality/aging	MP:0010768	5.5	ACE, AGT, AGTR1, OXT, ADM, AFP
4	homeostasis/metabolism phenotype	MP:0005376	5.2	AGT, AGTR1, OXT, ADM, AFP, CHRNG

Publications for genes affiliated with Oligohydramnios

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³⁵PubMed
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Articles related to oligohydramnios:

id	Title	Authors	Year	Affiliating Genes
1	Expression of aquaporin-1 in human oligohydramnios p lacenta and fetal membranes (19726340)	Hao R.Z.... Xiong Z.F.	2009	AQP1
2	Expression of aquaporin 1 and aquaporin 3 in fetal me mbranes and placenta in human term pregnancies with oligohydramnios. (19545896)	Zhu X.Q.... Hu Y.C.	2009	AQP1, AQP3
3	Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system. (16790508)	Lacoste M.... Gubler M.C.	2006	REN
4	Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins. (12861161)	Bajoria R.... Chatterjee R.	2003	EDN1, NPPB
5	Effects of exposure to tobacco smoke in pregnancies complicted by oligohydramnios and premature rupture of the membranes. II. Activity of brush border enzymes in human amniotic fluid. (11764857)	Milnerowicz H.... Woyton J.	2001	TREH
6	Localization of messenger ribonucleic acid for adrenomedullin and adrenomedullin receptor in the human placenta in normal pregnancies and pregnancies complicated by oligohydramnios. (11084568)	Apodaca C.C.... Calhoun B.C.	2000	ADM, GPR182
7	Activity of N-b-D-acetylglucosaminidase molecular forms in amniotic fluid of tobacco smoking pregnant women with oligohydramnios or premature rupture of the membrane complications (10860257)	Milnerowicz H.... WoytoA8 J.	2000	NAGLU
8	Maternal serum markers in second-trimester oligohydramnios. (7526364)	Los F.J.... Quartero H.W.	1994	CGA, AFP
9	Origin of raised maternal serum alpha-fetoprotein levels in second-trimester oligohydramnios. (1372972)	Los F.J.... Wladimiroff J.W.	1992	AFP
10	Oligohydramnios in mid-term pregnancy: analysis of 182 cases (2027677)	KovA!cs T.... Papp Z.	1991	AFP

Genes related to Oligohydramnios

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Genes related to oligohydramnios according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
2	AFP	alpha-fetoprotein	11.0	Publications
3	OXT	oxytocin, prepropeptide	11.0
4	ASPRV1	aspartic peptidase, retroviral-like 1	11.0
5	GPR182	G protein-coupled receptor 182	11.0	Publications
6	CHRND	cholinergic receptor, nicotinic, delta (muscle)	11.0
7	TREH	trehalase (brush-border membrane glycoprotein)	11.0	Publications
8	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	11.0
9	AQP8	aquaporin 8	11.0
10	SPAG5	sperm associated antigen 5	11.0
11	AQP11	aquaporin 11	11.0
12	AQP3	aquaporin 3 (Gill blood group)	11.0	Publications
13	ZFP62	zinc finger protein 62 homolog (mouse)	11.0
14	SRPX2	sushi-repeat containing protein, X-linked 2	11.0
15	PRUNE	prune homolog (Drosophila)	11.0
16	HHLA1	HERV-H LTR-associating 1	11.0	Disorders
17	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
18	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0
19	ADM	adrenomedullin	11.0	Publications
20	REN	renin	11.0	Publications
21	PKHD1	polycystic kidney and hepatic disease 1 (autosomal recessive)	11.0
22	NPPB	natriuretic peptide B	11.0	Publications
23	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0
24	AGTR1	angiotensin II receptor, type 1	11.0
25	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
26	EDN1	endothelin 1	11.0	Publications
27	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0

Expression for genes affiliated with Oligohydramnios

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Oligohydramnios

Pathways for genes affiliated with Oligohydramnios

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³⁸Reactome, ³⁴PharmGKB, ³⁶QIAGEN, ²⁰KEGG
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Pathways related to oligohydramnios according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Highly sodium permeable acetylcholine nicotinic receptors³⁸	10.1	CHRND, CHRNG
2	ACE Inhibitor Pathway, Pharmacodynamics³⁴	10.0	AGTR1
3	Passive Transport by Aquaporins³⁸	9.7	AQP8, AQP3, AQP1
4	eNOS Signaling³⁶	8.9	CHRND, AQP1, AQP11, AQP3, AQP8, CHRNG
5	Renin-angiotensin system²⁰	8.7	REN, ACE, AGT, AGTR1
6	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics³⁴	8.7	AGTR1, AGT, ACE, REN

Compounds for genes affiliated with Oligohydramnios

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³²Novoseek , ⁹DrugBank, ⁴²Tocris Bioscience, ³⁴PharmGKB, ¹⁸HMDB
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Compounds related to oligohydramnios according to GeneDecks:

(show top 50) (show all 153)

id	Compound	Score	Top Affiliating Genes
1	glucose³²	10.0	AQP3, TREH, AQP1
2	remikiren³² ⁹ ⁹	11.3	ACE, REN, AGT
3	alacepril³²	9.1	ACE, NPPB, REN
4	aliskiren³² ⁹ ⁹	11.0	AGTR1, ACE, AGT, REN
5	saralasin³² ⁴²	10.0	AGT, AGTR1, REN, ACE
6	fosinopril³² ⁹ ⁹	11.0	AGTR1, ACE, REN, NPPB
7	eprosartan³² ⁹ ⁹	11.0	AGT, ACE, REN, AGTR1
8	benazepril³² ⁹ ⁹	11.0	ACE, REN, AGT, AGTR1
9	olmesartan³² ⁹ ⁹	10.9	REN, AGTR1, AGT, ACE
10	mannitol³² ⁹ ⁹	10.9	AQP1, ADM, CGA, AQP3, NAGLU, OXT
11	furosemide³² ⁴² ³⁴ ⁹ ¹⁸ ⁹	13.8	ACE, AGTR1, NPPB, REN, NAGLU
12	omapatrilat³²	8.8	EDN1, ADM, REN, ACE
13	ramipril³² ⁹ ⁹	10.7	REN, ACE, NPPB, AGTR1
14	lacidipine³²	8.6	REN, EDN1, ACE, AGTR1
15	lisinopril³² ⁹ ¹⁸ ⁹	11.6	ACE, REN, AGTR1, NPPB, AGT
16	atenolol³² ⁹ ¹⁸ ⁹	11.6	AGT, ACE, NPPB, AGTR1, REN
17	telmisartan³² ⁹ ⁹	10.6	NPPB, AGTR1, AGT, ACE, REN
18	cilazapril³² ⁹ ⁹	10.6	EDN1, REN, ACE, AGTR1
19	candesartan³² ⁹ ⁹	10.6	NPPB, AGTR1, AGT, ACE, REN
20	amlodipine³² ⁹ ¹⁸ ⁹	11.6	ACE, AGT, NPPB, AGTR1, REN
21	quinapril³² ⁹ ⁹	10.5	ACE, AGTR1, REN, EDN1
22	perindopril³² ³⁴ ⁹ ⁹	11.5	AGTR1, AGT, ACE, REN, NPPB, NAGLU
23	sodium³² ¹⁸	9.4	REN, ADM, NPPB, AGTR1, AGT, AQP1
24	enalaprilat³²	8.3	ACE, EDN1, REN, AGT, NPPB
25	irbesartan³² ⁹ ⁹	10.3	AGTR1, ACE, REN, AGT
26	trandolapril³² ⁹ ⁹	10.3	ACE, AGTR1, EDN1, NPPB, REN
27	hydralazine³² ³⁴ ⁹ ⁹	11.3	ACE, AGTR1, EDN1, REN
28	chymostatin³²	8.2	AGTR1, AGT, REN, ACE, EDN1
29	l-nmma³²	8.1	AGT, AGTR1, NPPB, ADM, EDN1
30	potassium³² ⁹ ¹⁸ ⁹	11.0	AGTR1, AGT, REN, ACE, NAGLU, AQP1
31	carvedilol³² ³⁴ ⁹ ⁹	11.0	NPPB, AGTR1, ADM, EDN1, REN, ACE
32	nifedipine³² ⁹ ⁹	9.9	NAGLU, EDN1, AGT, OXT, AGTR1, REN
33	valsartan³² ⁴² ⁹ ⁹	10.8	AGT, EDN1, NPPB, AGTR1, REN, ACE
34	verapamil³² ³⁴ ⁹ ¹⁸ ⁹	11.8	AGTR1, ACE, EDN1, CGA, REN, NAGLU
35	enalapril³² ⁹ ⁹	9.7	REN, NAGLU, EDN1, NPPB, ACE, AGT
36	cgmp³²	7.7	AGTR1, ADM, REN, AQP1, EDN1, AGT
37	phenylephrine³² ⁹ ¹⁸ ⁹	10.6	CGA, EDN1, AGT, ADM, AGTR1, NPPB
38	steroid³²	7.6	NAGLU, CGA, AQP1, AGT, NPPB, ADM
39	sodium nitroprusside³²	7.5	AQP1, REN, EDN1, AGTR1, NPPB, ADM
40	captopril³² ⁴² ⁹ ⁹	10.5	REN, ADM, NPPB, AGT, ACE, AGTR1
41	ang ii³²	7.5	NPPB, ADM, EDN1, ACE, AGT, AGTR1
42	losartan³² ³⁴ ⁹ ⁹	10.4	ADM, NAGLU, EDN1, REN, NPPB, AGTR1
43	forskolin³² ⁴² ⁹ ⁹	10.4	ADM, AGTR1, AGT, REN, AQP1, AQP8
44	epinephrine³² ⁹ ¹⁸ ⁹	10.1	AFP, ADM, NPPB, REN, OXT, AGT
45	cyclosporin a³² ⁴²	8.0	SERPINH1, ADM, NAGLU, CGA, EDN1, AGT
46	prostacyclin³²	6.9	ADM, CGA, AGTR1, AGT, ACE, EDN1
47	norepinephrine³² ⁹ ¹⁸ ⁹	9.7	CGA, EDN1, ACE, REN, ADM, NPPB
48	nitric oxide³² ⁹ ¹⁸ ⁹	9.5	ACE, REN, SERPINH1, AGTR1, NAGLU, AGT
49	vegf³²	6.5	AGT, AFP, REN, ADM, SERPINH1, NPPB
50	creatinine³²	6.0	EDN1, AQP3, AFP, CGA, ADM, NPPB

GO Terms for genes affiliated with Oligohydramnios

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¹²Gene Ontology
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Cellular components related to oligohydramnios according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.3	REN, EDN1, ACE, AGT, OXT, NPPB

Biological processes related to oligohydramnios according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	urea transport	GO:015840	10.2	AQP3, AQP11
2	drinking behavior	GO:042756	10.2	OXT, REN
3	glycerol transport	GO:015793	10.1	AQP11, AQP1
4	water transport	GO:006833	9.9	AQP1, AQP11, AQP3, AQP8
5	positive regulation of NAD(P)H oxidase activity	GO:033864	9.8	AGTR1, AGT
6	regulation of renal output by angiotensin	GO:002019	9.8	AGT, ACE
7	regulation of blood vessel size by renin-angiotensin	GO:002034	9.8	AGTR1, AGT
8	regulation of renal sodium excretion	GO:035813	9.7	AGT, AGTR1
9	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	9.7	ACE, AGTR1
10	nitric oxide transport	GO:030185	9.6	EDN1, AQP1
11	transport	GO:006810	9.6	CHRNG, AFP, AQP8, AQP3, CHRND
12	renin-angiotensin regulation of aldosterone production	GO:002018	9.5	REN, AGT, AGTR1
13	regulation of vasodilation	GO:042312	9.3	NPPB, AGTR1, ACE
14	artery smooth muscle contraction	GO:014824	9.3	AGT, EDN1
15	positive regulation of cholesterol esterification	GO:010873	9.2	AGT, AGTR1
16	regulation of blood pressure	GO:008217	9.2	REN, ACE, NPPB
17	positive regulation of renal sodium excretion	GO:035815	9.0	NPPB, OXT, AGT, EDN1
18	heart development	GO:007507	9.0	ADM, NPPB, OXT, EDN1
19	elevation of cytosolic calcium ion concentration	GO:007204	8.9	EDN1, AGTR1, OXT, ADM
20	response to hypoxia	GO:001666	8.7	ADM, NPPB, EDN1, GPR182
21	regulation of vasoconstriction	GO:019229	8.5	AGTR1, AGT, ACE, EDN1
22	kidney development	GO:001822	8.4	REN, AQP11, PKHD1, ACE, AGT, AGTR1

Molecular functions related to oligohydramnios according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	water channel activity	GO:015250	9.7	AQP8, AQP3, AQP1
2	bradykinin receptor binding	GO:031711	9.4	ACE, AGTR1
3	acetyltransferase activator activity	GO:010698	9.2	AGT, AGTR1
4	hormone activity	GO:005179	7.8	CGA, EDN1, AGT, NPPB, ADM