MCID: OLG003
MIFTS: 50

Oligohydramnios malady

Summaries for Oligohydramnios

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards: Oligohydramnios, also known as oligohydramnios - delivered, is related to polyhydramnios and gastroschisis. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Calcium channels. The compounds gemeprost and diatrizoate have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and fetal lung, and related mouse phenotypes are mortality/aging and renal/urinary system.

Wikipedia:63 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Aliases & Classifications for Oligohydramnios

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

oligohydramnios 8 10 44 60
oligohydramnios - delivered 8 60
oligohydramnios, antepartum 60
antepartum oligohydramnios 8
delivered oligohydramnios 8


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Disease Ontology8 DOID:12215
ICD9CM27 658.0
MeSH34 D016104
ICD1025 O41.0

Related Diseases for Oligohydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.8AFP, OXT, AQP1
2gastroschisis30.0AFP
3diabetes insipidus29.8OXT
4hypertension29.8ADM
5pre-eclampsia29.8AFP, OXT, NAGLU, ADM
6potter's syndrome10.5
7renal agenesis10.3
8cervicitis10.2
9cerebritis10.1
10cleft palate10.1
11bilateral renal agenesis dominant type10.1
12anuria10.0
13twin-to-twin transfusion syndrome10.0
14polydactyly10.0
15meckel syndrome10.0
16potter syndrome type 110.0
17vesicoureteral reflux10.0NAGLU
18pyelonephritis10.0NAGLU
19peritonitis10.0AQP1
20primary hyperoxaluria10.0AQP1
21urinary tract obstruction10.0AQP3
22myasthenic syndrome, fast-channel congenital10.0CHRNA1, CHRND
23slow-channel congenital myasthenic syndrome10.0CHRNA1, CHRND
24edwards syndrome10.0AFP
25renal hypertension10.0GPR182, ADM
26chorioamnionitis10.0SERPINH1, OXT
27nephrogenic diabetes insipidus10.0OXT, AQP1
28diabetic angiopathy10.0ADM, NAGLU
29cystic lymphangioma10.0AFP, CHRNG, CHRND
30congenital myasthenic syndrome10.0CHRNA1, CHRND
31leiomyoma10.0ADM
32nephrotic syndrome10.0AQP3, NAGLU, TREH
33lipoid nephrosis10.0NAGLU, ADM
34multiple pterygium syndrome lethal type10.0CHRNG, CHRNA1, CHRND
35liver cirrhosis10.0ADM, AFP
36idiopathic edema10.0AQP1, ADM
37glomerulonephritis10.0SERPINH1, NAGLU
38choriocarcinoma10.0AFP, OXT, ADM
39neurofibromatosis9.9
40urethritis9.9
41cutis laxa9.9
42choroiditis9.9
43larsen syndrome9.9
44eclampsia9.9
45newborn respiratory distress syndrome9.9
46hydronephrosis9.9
47cushing's syndrome9.9
48wolf-hirschhorn syndrome9.9
49epiglottitis9.9
50hypospadias9.9

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to oligohydramnios

Clinical Features for Oligohydramnios

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Drugs & Therapeutics for Oligohydramnios

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Oligohydramnios

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Anatomical Context for Oligohydramnios

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32MalaCards
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MalaCards organs/tissues related to Oligohydramnios:

32
Lung, Placenta, Fetal lung, Kidney, Heart, Brain, Cervix, Breast, Testes, Spinal cord, Bone, Trachea

Animal Models for Oligohydramnios or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oligohydramnios:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.6CHRNG, CHRNA1, OXT, NAGLU, SERPINH1, ADM
2MP:00053678.6AQP11, TREH, OXT, NAGLU, ADM, AQP1

Publications for Oligohydramnios

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50PubMed
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Articles related to Oligohydramnios:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Management of severe idiopathic oligohydramnios: is antepartum transabdominal amnioinfusion really a treatment option? (23025586)
2013
2
Study of uterine and fetal hemodynamics in response to labor induction with dinoprostone in prolonged pregnancies with normal amniotic fluid and oligohydramnios. (24003884)
2013
3
Amnioinfusion before 26 weeks' gestation for severe fetal growth restriction with oligohydramnios: Preliminary pilot study. (24245667)
2013
4
Transabdominal amnioinfusion for improving fetal outcomes after oligohydramnios secondary to preterm prelabour rupture of membranes before 26 weeks. (23913522)
2013
5
Oligohydramnios associated with sonographically normal kidneys. (22088568)
2012
6
Spontaneous antepartum vesicouterine fistula causing severe oligohydramnios in a patient with a previous cesarean delivery. (22837297)
2012
7
Clinical significance of borderline amniotic fluid index and oligohydramnios in preterm pregnancy. (21252747)
2011
8
Assessing the optimal definition of oligohydramnios associated with adverse neonatal outcomes. (21357551)
2011
9
The role of antepartum transabdominal amnioinfusion in the management of oligohydramnios in pregnancy. (20608800)
2011
10
Herceptin (trastuzumab) therapy in a twin pregnancy with associated oligohydramnios. (19398090)
2009
11
Oligohydramnios at term: a case report. (17207755)
2007
12
Prognosis of antenatally diagnosed oligohydramnios of renal origin. (17205244)
2007
13
Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. (17519529)
2007
14
Predictors of perinatal survival in a cohort of pregnancies with severe oligohydramnios due to premature rupture of membranes at <26 weeks managed with serial amnioinfusions. (16530921)
2006
15
Paris heat wave and oligohydramnios. (15592298)
2004
16
Oligohydramnios and fetal renal sonographic appearances related to prostaglandin synthetase inhibitors. A case report. (15067231)
2004
17
De novo 4p-syndrome with oligohydramnios sequence. (14625611)
2003
18
Fibroepithelial bladder polyp and renal tubular dysgenesis: an unusual cause of third-trimester oligohydramnios. (11549150)
2001
19
Effects of exposure to tobacco smoke in pregnancies complicted by oligohydramnios and premature rupture of the membranes. II. Activity of brush border enzymes in human amniotic fluid. (11764857)
2001
20
Localization of messenger ribonucleic acid for adrenomedullin and adrenomedullin receptor in the human placenta in normal pregnancies and pregnancies complicated by oligohydramnios. (11084568)
2000
21
Prophylactic amnioinfusion for intrapartum oligohydramnios: a meta-analysis of randomized controlled trials. (11094242)
2000
22
Lymphoproliferative disorder of fetal origin presenting as oligohydramnios. (10328093)
1999
23
Chronic abruption-oligohydramnios sequence. (9610464)
1998
24
Transabdominal amnioinfusion in oligohydramnios at term before induction of labor with intact membranes: a randomized clinical trial. (8765270)
1996
25
Management of amniocentesis in women with oligohydramnios due to membrane rupture: evaluation of a cervical adapter. (7557639)
1995
26
Potter's syndrome in the second trimester--prenatal screening and pathological findings in 60 cases of oligohydramnios sequence. (7544896)
1995
27
Effects of dexamethasone and triiodothyronine on oligohydramnios-induced pulmonary hypoplasia. (8048991)
1994
28
Is oligohydramnios a risk factor for infection in term premature rupture of membranes? (12797198)
1994
29
Twin-to-twin transfusion syndrome: a subset of the twin oligohydramnios-polyhydramnios sequence. (8238150)
1993
30
Effect of in utero vesicostomy on pulmonary hypoplasia in the fetal lamb with bladder outlet obstruction and oligohydramnios: a morphometric analysis. (1895446)
1991
31
Oligohydramnios: antepartum fetal urine production and intrapartum fetal distress. (1951517)
1991
32
First- and early second-trimester oligohydramnios-a predictor of poor fetal outcome except in iatrogenic oligohydramnios post chorionic villus biopsy. (12797052)
1991
33
An infant having Potter facies without pulmonary hypoplasia after prolonged oligohydramnios due to a placental mass. (1743221)
1991
34
Dehydration-induced oligohydramnios. (2271040)
1990
35
Extrinsic fetal akinesia and skeletal development: a study in oligohydramnios sequence. (2392775)
1990
36
Management of midtrimester oligohydramnios: a case for amnioinfusion. (2358897)
1990
37
Oligohydramnios in each sac of a triplet gestation caused by Motrin--fulfilling Kock's postulates. (2309829)
1990
38
A mechanism leading to reduced lung expansion and lung hypoplasia in fetal sheep during oligohydramnios. (2256503)
1990
39
Intrapartum amniotic fluid volume at term. Association of ruptured membranes, oligohydramnios and increased fetal risk. (2198351)
1990
40
Sonography of placental abnormalities and oligohydramnios in women with elevated alpha-fetoprotein levels: comparison with control subjects. (2476009)
1989
41
Saline solution amnioinfusion for oligohydramnios after premature rupture of the membranes. A preliminary report. (2665490)
1989
42
Dry lung syndrome after oligohydramnios. (3279926)
1988
43
Polyhydramnios and oligohydramnios in twin gestations. (3285268)
1988
44
Elevated maternal serum alpha-fetoprotein with oligohydramnios: ultrasound evaluation and outcome. (2457190)
1988
45
Subcellular effects of experimental oligohydramnios on the developing rat limb. (3672370)
1987
46
Oligohydramnios is a contraindication to amniocentesis. (6102258)
1980
47
Scanning electron microscopic appearances in the amnion in polyhydramnios and oligohydramnios. (371665)
1979
48
Renal anomalies and oligohydramnios in the cerebro-oculofacio-skeletal syndrome. (402067)
1977
49
Fetal pulmonary hypoplasia, anuria, and oligohydramnios: clinicopathologic observations and review of the literature. (4817648)
1974
50
Hydramnios, oligohydramnios and fetal malformations. (5330420)
1966

Genetic Variations for Oligohydramnios

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Expression for genes affiliated with Oligohydramnios

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligohydramnios

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Pathways for genes affiliated with Oligohydramnios

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53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Oligohydramnios

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1gemeprost4410.4OXT, AFP
2diatrizoate4410.4AQP1, NAGLU
3pcmbs4410.4AQP3, AQP1
4hgcl24410.3AQP3, AQP1
5mercury4410.3NAGLU, AQP1, AQP3
6bibn 4096 bs4410.3GPR182, ADM
7galantamine44 49 1112.3CHRND, CHRNA1, CHRNG
8hg2+2810.2AQP1, AQP3, AQP8
9streptozotocin4410.2ADM, NAGLU, OXT
10forskolin44 49 1112.2AQP8, AQP3, ADM
11silver4410.2AFP, AQP1, AQP3
12urea44 11 2412.2AFP, NAGLU, AQP1, AQP3
13gentamicin44 1111.1NAGLU, OXT
14glycerol44 11 2412.0ADM, AQP1, AQP3, AQP8
15mannitol44 1110.9AQP3, AQP1, ADM, NAGLU, OXT
16potassium44 11 2411.8AQP1, ADM, NAGLU, AFP
17creatinine449.8AFP, OXT, NAGLU, ADM, AQP1, AQP3
18steroid449.7AFP, OXT, NAGLU, ADM, AQP1
19oligonucleotide449.7AFP, SERPINH1, ADM, AQP1, AQP3
20paraffin449.6AFP, OXT, ADM, AQP1
21glucose449.6AFP, TREH, NAGLU, ADM, AQP1, AQP3
22vegf449.2AQP1, ADM, SERPINH1, OXT, AFP

GO Terms for genes affiliated with Oligohydramnios

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16Gene Ontology
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Cellular components related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.0CHRND, CHRNA1, CHRNG

Biological processes related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.2CHRNA1, CHRND
2neuromuscular processGO:05090510.1CHRND, CHRNA1
3glycerol transportGO:01579310.1AQP11, AQP1
4urea transportGO:01584010.1AQP11, AQP3
5musculoskeletal movementGO:05088110.0CHRNA1, CHRND
6water transportGO:0068339.8AQP11, AQP8, AQP3, AQP1
7regulation of membrane potentialGO:0423919.7CHRND, CHRNA1, CHRNG
8transportGO:0068109.6AFP, CHRNG, CHRNA1, CHRND, AQP3, AQP8

Molecular functions related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.1CHRNA1, CHRNG
2water channel activityGO:0152509.9AQP8, AQP3, AQP1
3acetylcholine-activated cation-selective channel activityGO:0048899.9CHRNG, CHRNA1, CHRND
4acetylcholine bindingGO:0421669.8CHRND, CHRNA1

Products for genes affiliated with Oligohydramnios

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Sources for Oligohydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet