MCID: OLG003
MIFTS: 50

Oligohydramnios malady

Summaries for Oligohydramnios

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards: Oligohydramnios, also known as oligohydramnios - delivered, is related to polyhydramnios and gastroschisis. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Calcium channels. The compounds gemeprost and diatrizoate have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and fetal lung, and related mouse phenotypes are mortality/aging and renal/urinary system.

Wikipedia:63 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Aliases & Classifications for Oligohydramnios

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

oligohydramnios 8 10 44 60
oligohydramnios - delivered 8 60
oligohydramnios, antepartum 60
antepartum oligohydramnios 8
delivered oligohydramnios 8


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Disease Ontology8 DOID:12215
ICD9CM27 658.0
MeSH34 D016104
ICD1025 O41.0

Related Diseases for Oligohydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.8AFP, OXT, AQP1
2gastroschisis30.0AFP
3diabetes insipidus29.8OXT
4hypertension29.8ADM
5pre-eclampsia29.8AFP, OXT, NAGLU, ADM
6potter's syndrome10.5
7renal agenesis10.3
8cervicitis10.2
9cerebritis10.1
10cleft palate10.1
11bilateral renal agenesis dominant type10.1
12anuria10.0
13twin-to-twin transfusion syndrome10.0
14polydactyly10.0
15meckel syndrome10.0
16potter syndrome type 110.0
17vesicoureteral reflux10.0NAGLU
18pyelonephritis10.0NAGLU
19peritonitis10.0AQP1
20primary hyperoxaluria10.0AQP1
21urinary tract obstruction10.0AQP3
22myasthenic syndrome, fast-channel congenital10.0CHRNA1, CHRND
23slow-channel congenital myasthenic syndrome10.0CHRNA1, CHRND
24edwards syndrome10.0AFP
25renal hypertension10.0GPR182, ADM
26chorioamnionitis10.0SERPINH1, OXT
27nephrogenic diabetes insipidus10.0OXT, AQP1
28diabetic angiopathy10.0ADM, NAGLU
29cystic lymphangioma10.0AFP, CHRNG, CHRND
30congenital myasthenic syndrome10.0CHRNA1, CHRND
31leiomyoma10.0ADM
32nephrotic syndrome10.0AQP3, NAGLU, TREH
33lipoid nephrosis10.0NAGLU, ADM
34multiple pterygium syndrome lethal type10.0CHRNG, CHRNA1, CHRND
35liver cirrhosis10.0ADM, AFP
36idiopathic edema10.0AQP1, ADM
37glomerulonephritis10.0SERPINH1, NAGLU
38choriocarcinoma10.0AFP, OXT, ADM
39neurofibromatosis9.9
40urethritis9.9
41cutis laxa9.9
42choroiditis9.9
43larsen syndrome9.9
44eclampsia9.9
45newborn respiratory distress syndrome9.9
46hydronephrosis9.9
47cushing's syndrome9.9
48wolf-hirschhorn syndrome9.9
49epiglottitis9.9
50hypospadias9.9

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to oligohydramnios

Clinical Features for Oligohydramnios

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Drugs & Therapeutics for Oligohydramnios

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Oligohydramnios

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Anatomical Context for Oligohydramnios

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32MalaCards
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MalaCards organs/tissues related to Oligohydramnios:

32
Lung, Placenta, Fetal lung, Kidney, Heart, Brain, Bone, Cervix, Testes, Breast, Spinal cord, Trachea

Animal Models for Oligohydramnios or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oligohydramnios:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.6CHRNG, CHRNA1, OXT, NAGLU, SERPINH1, ADM
2MP:00053678.6AQP11, TREH, OXT, NAGLU, ADM, AQP1

Publications for Oligohydramnios

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50PubMed
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Articles related to Oligohydramnios:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Recurrent severe oligohydramnios and fetal pulmonary hypoplasia associated with ErbB4 mutation. (23344421)
2013
2
Effects of maternal retinoic acid administration on lung angiogenesis in oligohydramnios-exposed fetal rats. (23590952)
2013
3
Prenatal diagnosis of mosaic trisomy 2 associated with abnormal maternal serum screening, oligohydramnios, intrauterine growth restriction, ventricular septal defect, preaxial polydactyly, and facial dysmorphism. (24075380)
2013
4
Effect of maternal oral hydration therapy in oligohydramnios. (23134924)
2012
5
Oral hydration therapy in oligohydramnios. (20149038)
2009
6
The experience of amnioinfusion for oligohydramnios during the early second trimester. (18182345)
2007
7
Antenatal oligohydramnios of renal origin: long-term outcome. (17065192)
2007
8
Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2 alpha receptor. (16882262)
2006
9
Isolated oligohydramnios is not associated with adverse perinatal outcomes. (14961882)
2004
10
Strategies of cardiovascular and ventilatory management in preterm infants with prolonged rupture of fetal membranes and oligohydramnios. (12168134)
2002
11
Choroid plexus cysts and oligohydramnios: presenting echographic signs in a female fetus with deletion of the Wolf-Hirschhorn syndrome region (4p16.3). (11837610)
2001
12
The relationship between oligohydramnios and the onset of preterm labor in preterm premature rupture of membranes. (11228503)
2001
13
Severe oligohydramnios with intact membranes: an indication for diagnostic amnioinfusion. (10705214)
2000
14
Special imaging casebook. Oligohydramnios sequence with bilateral renal agenesis (Potter's syndrome). (11002883)
2000
15
Predictive value of serial middle cerebral and renal artery pulsatility indices in fetuses with oligohydramnios. (10902823)
2000
16
Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour. (10796170)
2000
17
Acute oligohydramnios and deteriorating fetal biophysical profile associated with severe preeclampsia. (10406305)
1999
18
Diamniotic twin gestation discordant for renal dysplasia and oligohydramnios. (10754159)
1999
19
Association of oligohydramnios in women with preterm premature rupture of membranes with an inflammatory response in fetal, amniotic, and maternal compartments. (10521729)
1999
20
Effect of maternal hydration on oligohydramnios: a comparison of three volume expansion methods. (9764623)
1998
21
The effect of polyhydramnios and oligohydramnios on fetal lung maturity indexes. (9565223)
1998
22
Serial transabdominal amnioinfusion in the management of gastrochisis with severe oligohydramnios. (9607509)
1998
23
Is fetal thoracic compression really the underlying mechanism of lung hypoplasia in oligohydramnios? An experimental study in a rabbit model. (9165252)
1997
24
Oligohydramnios and the appropriately grown fetus. (9217959)
1997
25
Reversible oligohydramnios in a pregnancy with angiotensin-converting enzyme inhibitor exposure. (9394157)
1997
26
The effects of oligohydramnios and cervical cord transection on lung growth in experimental pulmonary hypoplasia in rabbits. (9240585)
1997
27
Serial transabdominal amnioinfusion in the management of gastroschisis with severe oligohydramnios. (8887108)
1996
28
Dolichocephaly and oligohydramnios in preterm premature rupture of the membranes. (8731444)
1996
29
Outcome of singleton pregnancies with severe oligohydramnios in the second and third trimesters. (8776235)
1996
30
Congenital cytomegalovirus infection with oligohydramnios and echogenic bowel at 14 weeks' gestation. (7474061)
1995
31
Oligohydramnios: maternal complications and fetal outcome in 145 cases. (8150377)
1994
32
Prophylactic amnioinfusion for oligohydramnios: a reevaluation. (8090391)
1994
33
Late onset severe oligohydramnios associated with genitourinary abnormalities. (1640513)
1992
34
Relief of presumed compression in oligohydramnios: amnioinfusion does not affect umbilical artery Doppler waveforms. (1492906)
1992
35
Amniotic fluid volume assessment: oligohydramnios. (1997876)
1991
36
Oligohydramnios. (2810473)
1989
37
Umbilical artery velocimetry as a predictor of adverse outcome in pregnancies complicated by oligohydramnios. (2668816)
1989
38
Magnetic resonance imaging as an adjunct to ultrasound in oligohydramnios. Detection of sirenomelia. (2657096)
1989
39
Prolonged maternal indomethacin therapy associated with oligohydramnios. Case reports. (3191072)
1988
40
Prolonged maternal indomethacin therapy associated with oligohydramnios. Case reports. (3370202)
1988
41
Fetal breathing movements as predictor of favourable pregnancy outcome after oligohydramnios due to membrane rupture in second trimester. (2885600)
1987
42
Doppler ultrasound assessment of fetal and uteroplacental circulations in severe second trimester oligohydramnios. (3322369)
1987
43
Oligohydramnios-induced lung hypoplasia: the influence of timing and duration in gestation. (3774409)
1986
44
Degree of oligohydramnios and pregnancy outcome in patients with premature rupture of the membranes. (3895069)
1985
45
A technique for mid-trimester termination of pregnancies with severe oligohydramnios. (3903190)
1985
46
Experimental pulmonary hypoplasia and oligohydramnios: relative contributions of lung fluid and fetal breathing movements. (6520670)
1984
47
Brain abnormalities in infants with Potter syndrome (oligohydramnios tetrad). (7198213)
1981
48
Raised maternal serum alpha-fetoprotein, oligohydramnios, and the fetus. (6153446)
1980
49
Oligohydramnios and fatal pulmonary hypoplasia without amnion nodosum. (671406)
1978
50
Diagnosis oligohydramnios-related pulmonary hypoplasia (Potter syndrome): value of portable voiding cystourethrography in newborns with respiratory distress. (928707)
1977

Genetic Variations for Oligohydramnios

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Expression for genes affiliated with Oligohydramnios

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligohydramnios

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Pathways for genes affiliated with Oligohydramnios

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53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Oligohydramnios

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1gemeprost4410.4OXT, AFP
2diatrizoate4410.4AQP1, NAGLU
3pcmbs4410.4AQP3, AQP1
4hgcl24410.3AQP3, AQP1
5mercury4410.3NAGLU, AQP1, AQP3
6bibn 4096 bs4410.3GPR182, ADM
7galantamine44 49 1112.3CHRND, CHRNA1, CHRNG
8hg2+2810.2AQP1, AQP3, AQP8
9streptozotocin4410.2ADM, NAGLU, OXT
10forskolin44 49 1112.2AQP8, AQP3, ADM
11silver4410.2AFP, AQP1, AQP3
12urea44 11 2412.2AFP, NAGLU, AQP1, AQP3
13gentamicin44 1111.1NAGLU, OXT
14glycerol44 11 2412.0ADM, AQP1, AQP3, AQP8
15mannitol44 1110.9AQP3, AQP1, ADM, NAGLU, OXT
16potassium44 11 2411.8AQP1, ADM, NAGLU, AFP
17creatinine449.8AFP, OXT, NAGLU, ADM, AQP1, AQP3
18steroid449.7AFP, OXT, NAGLU, ADM, AQP1
19oligonucleotide449.7AFP, SERPINH1, ADM, AQP1, AQP3
20paraffin449.6AFP, OXT, ADM, AQP1
21glucose449.6AFP, TREH, NAGLU, ADM, AQP1, AQP3
22vegf449.2AQP1, ADM, SERPINH1, OXT, AFP

GO Terms for genes affiliated with Oligohydramnios

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16Gene Ontology
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Cellular components related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.0CHRND, CHRNA1, CHRNG

Biological processes related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.2CHRNA1, CHRND
2neuromuscular processGO:05090510.1CHRND, CHRNA1
3glycerol transportGO:01579310.1AQP11, AQP1
4urea transportGO:01584010.1AQP11, AQP3
5musculoskeletal movementGO:05088110.0CHRNA1, CHRND
6water transportGO:0068339.8AQP11, AQP8, AQP3, AQP1
7regulation of membrane potentialGO:0423919.7CHRND, CHRNA1, CHRNG
8transportGO:0068109.6AFP, CHRNG, CHRNA1, CHRND, AQP3, AQP8

Molecular functions related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.1CHRNA1, CHRNG
2water channel activityGO:0152509.9AQP8, AQP3, AQP1
3acetylcholine-activated cation-selective channel activityGO:0048899.9CHRNG, CHRNA1, CHRND
4acetylcholine bindingGO:0421669.8CHRND, CHRNA1

Products for genes affiliated with Oligohydramnios

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  • Antibodies
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Sources for Oligohydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet