Aliases & Classifications for Oligohydramnios

MalaCards integrated aliases for Oligohydramnios:

Name: Oligohydramnios 12 28 51 41 14 69
Oligohydramnios - Delivered 12 69
Oligohydramnios, Antepartum Condition or Complication 69
Antepartum Oligohydramnios 12
Delivered Oligohydramnios 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12215
ICD10 32 O41.0 O41.00
ICD9CM 34 658.0
MeSH 41 D016104
NCIt 46 C92839

Summaries for Oligohydramnios

Disease Ontology : 12 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards based summary : Oligohydramnios, also known as oligohydramnios - delivered, is related to potter's syndrome and renal tubular dysgenesis, and has symptoms including morning sickness An important gene associated with Oligohydramnios is PKHD1 (PKHD1, Fibrocystin/Polyductin). The drugs Warfarin and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and bone.

Wikipedia : 72 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Related Diseases for Oligohydramnios

Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 potter's syndrome 11.9
2 renal tubular dysgenesis 11.4
3 renal hypodysplasia/aplasia 1 11.2
4 meckel syndrome, type 1 11.1
5 twin-to-twin transfusion syndrome 11.1
6 bilateral renal agenesis dominant type 11.1
7 polycystic kidney disease 4 with or without hepatic disease 11.0
8 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.9
9 urethral obstruction sequence 10.9
10 congenital anomalies of kidney and urinary tract 2 10.8
11 multiple pterygium syndrome, lethal type 10.8
12 renal dysplasia-limb defects syndrome 10.8
13 fetal indomethacin syndrome 10.8
14 trisomy 2 mosaicism 10.8
15 polyhydramnios 10.3
16 preterm premature rupture of the membranes 10.2
17 alpha-fetoprotein deficiency 10.1
18 aging 10.0
19 cervicitis 10.0
20 cleft palate, isolated 9.9
21 gastroschisis 9.9
22 cerebritis 9.9
23 cytomegalovirus infection 9.9
24 polydactyly 9.8
25 hydrops fetalis, nonimmune, and/or atrial septal defect 9.8
26 pre-eclampsia 9.8
27 eclampsia 9.8
28 vaginitis 9.8
29 anuria 9.8
30 diabetes insipidus 9.8
31 congenital cytomegalovirus 9.8
32 hydrops fetalis 9.8
33 renal dysplasia 9.8
34 diabetes insipidus, neurohypophyseal 9.6
35 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.6
36 diaphragmatic hernia, congenital 9.6
37 larsen syndrome 9.6
38 neurofibromatosis, type iv, of riccardi 9.6
39 rheumatoid arthritis 9.6
40 tracheoesophageal fistula with or without esophageal atresia 9.6
41 wolf-hirschhorn syndrome 9.6
42 fetal akinesia deformation sequence 9.6
43 pierre robin syndrome 9.6
44 ayme-gripp syndrome 9.6
45 renal dysplasia, cystic 9.6
46 anxiety 9.6
47 malaria 9.6
48 short-rib thoracic dysplasia 10 with or without polydactyly 9.6
49 autoimmune lymphoproliferative syndrome, type v 9.6
50 arthrogryposis multiplex congenita, neurogenic, with myelin defect 9.6

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to Oligohydramnios

Symptoms & Phenotypes for Oligohydramnios

UMLS symptoms related to Oligohydramnios:


morning sickness

Drugs & Therapeutics for Oligohydramnios

Drugs for Oligohydramnios (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 54678486 6691
2 Tocopherol Approved, Investigational, Nutraceutical Phase 4
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Anticoagulants Phase 4
5 Vitamins Phase 4
6 Coagulants Phase 4
7 Antioxidants Phase 4,Phase 2,Phase 3
8 Protective Agents Phase 4,Phase 2,Phase 3
9 Tocopherols Phase 4
10 Tocotrienols Phase 4
11
Coumarin Experimental, Nutraceutical Phase 4 91-64-5 323
12 Omega 3 Fatty Acid Nutraceutical Phase 4
13 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
14
Dinoprostone Approved Phase 3 363-24-6 5280360
15
Isosorbide Dinitrate Approved, Investigational Phase 2, Phase 3 87-33-2 6883
16
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
17
Oxytocin Approved, Vet_approved Phase 3 50-56-6 53477758 439302
18 Oxytocics Phase 3
19 Vasodilator Agents Phase 2, Phase 3
20 Anti-Asthmatic Agents Phase 2, Phase 3
21 Autonomic Agents Phase 2, Phase 3
22 Bronchodilator Agents Phase 2, Phase 3
23 diuretics Phase 2, Phase 3
24 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
25 Isosorbide Phase 2, Phase 3
26 isosorbide-5-mononitrate Phase 2, Phase 3
27 Natriuretic Agents Phase 2, Phase 3
28 Neurotransmitter Agents Phase 2, Phase 3
29 Nitric Oxide Donors Phase 2, Phase 3
30 Peripheral Nervous System Agents Phase 2, Phase 3
31 Respiratory System Agents Phase 2, Phase 3
32
Misoprostol Approved 59122-46-2 5282381
33
Menthol Approved 2216-51-5 16666
34
Adenosine Approved, Investigational 58-61-7 60961
35
Pertuzumab Approved 380610-27-5, 145040-37-5 2540
36
Trastuzumab Approved, Investigational 180288-69-1 9903
37
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
38
Indomethacin Approved, Investigational 53-86-1 3715
39
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
40
Cholecalciferol Approved, Nutraceutical 67-97-0 10883523 5280795 6221
41
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
42
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
43 Calcium, Dietary
44 Chelating Agents
45 Phosphodiesterase 5 Inhibitors
46 Phosphodiesterase Inhibitors
47 Sildenafil Citrate 171599-83-0
48 Bone Density Conservation Agents
49 Ergocalciferols
50 Micronutrients

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Active Induction of Labor in Pregnancies Complicated With Oligohydramnios at Term Completed NCT02581774 Phase 4
2 Warfarine in Unexplained Oligohydramnios Completed NCT01569035 Phase 4 warfarin
3 Role of Antioxidants in Unexplained Oligohydramnios,A Randomized Trial Completed NCT01990690 Phase 4 anti oxidant omega 3
4 Amnioinfusion Initiative Unknown status NCT00787163 Phase 3
5 Induction of Labor in Oligohydramnios Unknown status NCT00815542 Phase 3 prostaglandins E2
6 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
7 Nitric Oxide Donors for Treatment of Isolated Oligohydramnios Completed NCT02712125 Phase 2, Phase 3 isosorbide mononitrate;Placebo
8 Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies Recruiting NCT02907060 Phase 3 Pharmacological cervical ripening
9 Stepwise Labor Induction Following Failure of Prostaglandin Vaginal Insert for Labor Induction Not yet recruiting NCT02684305 Phase 3 Administration of Propess;Intravenous oxytocin infusion
10 Alterations of the Uteroplacental and Fetal Pulmonary Circulation Following Amnioinfusion Unknown status NCT01258725 Phase 1
11 Sildenafil Citrate Therapy for Oligohydramnios Unknown status NCT02372487 sildenafil citrate
12 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
13 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328
14 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
15 Studying Fetal Breathing Patterns Completed NCT00066976
16 Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor Completed NCT01140971 Misoprostol
17 Perinatal Outcome After Premature Rupture of Membranes Completed NCT01538030
18 Functional Capacity After Computer Assisted Periacetabular Osteotomy in Patients With Hip Dysplasia Completed NCT02015247
19 Fetal Renal Artery Doppler Indices in Borderline Isolated Oligohydramnios Recruiting NCT02901340
20 PPROM Registry (Preterm Premature Rupture of Membranes) Recruiting NCT02997345
21 Renal Agenesis Fetal Therapy Recruiting NCT03101891 Normal Saline, 0.9% injectable solution
22 A Study of Pregnancy and Pregnancy Outcomes in Women With Breast Cancer Treated With Trastuzumab, Pertuzumab in Combination With Trastuzumab, or Ado-Trastuzumab Emtansine Recruiting NCT00833963 Trastuzumab;Pertuzumab;Ado-Trastuzumab Emtansine
23 Indomethacin PK and PD Therapy in Pregnancy Recruiting NCT02451228
24 Does Amniotic Fluid Index Affect the Fetal Cardiac Performance? Not yet recruiting NCT03277417
25 Hydrotherapy for the Reversal of Oligohydramnios Terminated NCT01682928 IV/Oral Hydration and Bedrest

Search NIH Clinical Center for Oligohydramnios

Cochrane evidence based reviews: oligohydramnios

Genetic Tests for Oligohydramnios

Genetic tests related to Oligohydramnios:

# Genetic test Affiliating Genes
1 Oligohydramnios 28

Anatomical Context for Oligohydramnios

MalaCards organs/tissues related to Oligohydramnios:

38
Lung, Placenta, Bone, Breast, Fetal Lung, Liver, Kidney

Publications for Oligohydramnios

Articles related to Oligohydramnios:

(show top 50) (show all 467)
# Title Authors Year
1
Induction of labor in cases of late preterm isolated oligohydramnios: is it justified? ( 29343146 )
2018
2
Sildenafil Citrate Therapy for Oligohydramnios: A Randomized Controlled Trial. ( 28644321 )
2017
3
Oligohydramnios compromises lung cells size and interferes with epithelial-endothelial development. ( 28152278 )
2017
4
Prenatal parental decision-making and postnatal outcome in renal oligohydramnios. ( 29075889 )
2017
5
Perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios. ( 28782398 )
2017
6
Oligohydramnios is an independent risk factor for perinatal morbidity among women with pre-eclampsia who delivered preterm. ( 29237307 )
2017
7
A case of gestational central diabetes insipidus with oligohydramnios. ( 28764595 )
2017
8
Causes of renal oligohydramnios: impact on prenatal counseling and postnatal outcome. ( 29128922 )
2017
9
MRI findings of chronic abruption-oligohydramnios sequence (CAOS): report of three cases. ( 28396921 )
2017
10
Pregnancy Outcomes in Isolated Oligohydramnios during Second Trimester: A Case Series. ( 28969220 )
2017
11
Sildenafil Citrate Therapy for Oligohydramnios: A Randomized Controlled Trial. ( 29064958 )
2017
12
Midtrimester isolated oligohydramnios in monochorionic diamniotic multiple gestations<sup/>. ( 28965437 )
2017
13
Inhaled Nitric Oxide in preterm Neonates with refractory hypoxemia associated to oligohydramnios. ( 29046161 )
2017
14
Report of a Triploid Fetus Identified in a Pregnancy with Oligohydramnios. ( 28459702 )
2017
15
Sildenafil Citrate Therapy for Oligohydramnios: A Randomized Controlled Trial. ( 28277352 )
2017
16
Evaluation of Maternal and Perinatal Outcomes of Induction in Borderline Oligohydramnios at Term. ( 29207783 )
2017
17
Oligohydramnios and growth restriction do not portend worse prognosis in gastroschisis pregnancies. ( 26932657 )
2016
18
Induction of Labor in Women with Oligohydramnios: Misoprostol Compared with Prostaglandin E2. ( 27398704 )
2016
19
Are Major Depression and Generalized Anxiety Disorder Associated With Oligohydramnios in Pregnant Women? A Case-Control Study. ( 27357862 )
2016
20
Survival of fetuses with severe oligohydramnios. ( 27328487 )
2016
21
Lack of pharmacist-physician communication associated with nimesulide-induced oligohydramnios during pregnancy. ( 26951121 )
2016
22
Oligohydramnios in complicated and uncomplicated pregnancies: a systematic review and meta-analysis. ( 27062200 )
2016
23
Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study. ( 27324123 )
2016
24
Aquaporin 3 Expression Induced by Salvia Miltiorrhiza via ERK1/2 Signal Pathway in the Primary Human Amnion Epithelium Cells from Isolated Oligohydramnios. ( 26917259 )
2016
25
Sildenafil citrate for the management of fetal growth restriction and oligohydramnios. ( 27563258 )
2016
26
Role of l-Arginine in Oligohydramnios. ( 27651617 )
2016
27
Isolated Oligohydramnios at Term as an Indication for Labor Induction: A Systematic Review and Meta-Analysis. ( 27160748 )
2016
28
A randomized controlled study of the efficacy of 4 weeks of supplementation with I8-3 polyunsaturated fatty acids in cases of unexplained oligohydramnios. ( 27559716 )
2016
29
Significance of oligohydramnios in preterm small-for-gestational-age infants for outcome at 18 months of age. ( 27352940 )
2016
30
Use of an Amnioport to Maintain Amniotic Fluid Volume in Fetuses with Oligohydramnios Secondary to Lower Urinary Tract Obstruction or Fetal Renal Anomalies. ( 27287190 )
2016
31
Obstetric outcomes of isolated oligohydramnios during early-term, full-term and late-term periods and determination of optimal timing of delivery. ( 27225520 )
2016
32
EP16.18: Outcome of the patients with late second trimester isolated oligohydramnios and echogenic bowel without evidence of premature rupture membranes. ( 27644197 )
2016
33
Prostaglandin E2 induction of labor and cervical ripening for term isolated oligohydramnios in pregnant women with Bishop scoreA a8oA 5. ( 27745800 )
2016
34
Important clinical information from successful treatment of a case with isolated severe oligohydramnios and deficient fetal growth late in the second trimester. ( 26384073 )
2015
35
Reversible oligohydramnios in the second trimester of pregnancy in two patients with long-term diclofenac exposure. ( 26318712 )
2015
36
An Update on Maternal Hydration Strategies for Amniotic Fluid Improvement in Isolated Oligohydramnios and Normohydramnios: Evidence from a Systematic Review of Literature and Meta-Analysis. ( 26658482 )
2015
37
Feasibility and preliminary outcomes of fetoscopic laser photocoagulation for monochorionic twin gestation with selective intrauterine growth restriction accompanied by severe oligohydramnios. ( 26369752 )
2015
38
What does fetal autopsy unmask in oligohydramnios? ( 26381033 )
2015
39
Placental lesions associated with oligohydramnios in fetal growth restricted (FGR) pregnancies. ( 25735841 )
2015
40
Outcomes and management strategies in pregnancies with early onset oligohydramnios. ( 26152010 )
2015
41
Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. ( 26444125 )
2015
42
Perinatal outcomes with isolated oligohydramnios at term pregnancy. ( 26506098 )
2015
43
Intra-vaginal prostaglandin E2 versus double-balloon catheter for labor induction in term oligohydramnios. ( 25275693 )
2014
44
Oligohydramnios sequence revisited in relationship to arthrogryposis, with distinctive skin changes. ( 25160497 )
2014
45
Oligohydramnios in a pregnant Pakistani woman with Plasmodium vivax malaria. ( 24758193 )
2014
46
Severe midtrimester oligohydramnios: treatment strategies. ( 24614021 )
2014
47
Maternal hydration therapy improves the quantity of amniotic fluid and the pregnancy outcome in third-trimester isolated oligohydramnios. ( 24764350 )
2014
48
Which is the safer method of labor induction for oligohydramnios women? Transcervical double balloon catheter or dinoprostone vaginal insert. ( 24397441 )
2014
49
Oligohydramnios in women with preterm prelabor rupture of membranes and adverse pregnancy and neonatal outcomes. ( 25171293 )
2014
50
Therapeutic amnioinfusion for chronic abruption-oligohydramnios sequence: A possible prevention of the infant respiratory disease. ( 24428672 )
2014

Variations for Oligohydramnios

ClinVar genetic disease variations for Oligohydramnios:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh37 Chromosome 8, 94808198: 94808198
2 PKHD1 NM_138694.3(PKHD1): c.107C> T (p.Thr36Met) single nucleotide variant Pathogenic,protective rs137852944 GRCh37 Chromosome 6, 51947999: 51947999
3 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh38 Chromosome 8, 93786255: 93786255

Expression for Oligohydramnios

Search GEO for disease gene expression data for Oligohydramnios.

Pathways for Oligohydramnios

GO Terms for Oligohydramnios

Sources for Oligohydramnios

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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