MCID: OLG003
MIFTS: 60

Oligohydramnios malady

Fetal diseases category
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Summaries for Oligohydramnios

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Disease Ontology:8 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards based summary: Oligohydramnios, also known as oligohydramnios - delivered, is related to polyhydramnios and diabetes insipidus. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Physiological and Pathological Hypertrophy of the Heart and Sympathetic Nerve Pathway (Neuroeffector Junction). The compounds aliskiren and omapatrilat have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and kidney, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:65 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Aliases & Classifications for Oligohydramnios

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Oligohydramnios, Aliases & Descriptions:

Name: Oligohydramnios 8 10 44 62
Oligohydramnios - Delivered 8 62
Oligohydramnios, Antepartum 62
 
Antepartum Oligohydramnios 8
Delivered Oligohydramnios 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:12215
ICD9CM27 658.0
MeSH34 D016104
ICD1025 O41.0

Related Diseases for Oligohydramnios

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Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios31.4AFP, AQP1, OXT
2diabetes insipidus30.6OXT
3renal tubular dysgenesis30.4REN, AGT, AGTR1
4placental abruption30.4SERPINH1, AFP
5diabetes mellitus28.6EDN1, NAGLU, REN, ACE, NPPB, AGT
6pre-eclampsia28.5EDN1, AFP, NAGLU, ADM, OXT, REN
7hypertension28.5EDN1, ADM, REN, ACE, NPPB, AGT
8endodermal sinus tumor10.6AFP
9fibromuscular dysplasia10.5REN
10congestive heart failure10.5REN
11potter's syndrome10.5
12hypoaldosteronism10.5REN
13male germ cell tumor, somatic10.4AFP, CGA
14nephrogenic diabetes insipidus10.4AQP1, OXT
15edwards syndrome10.4CGA, AFP
16anencephaly10.4AFP, CGA
17germinoma10.4AFP, CGA
18germ cell cancer10.4AFP, CGA
19endometritis10.4SERPINH1, OXT
20mitral valve prolapse10.4AGTR1
21lipoid nephrosis10.4NAGLU, ADM
22borderline personality disorder10.3OXT, CGA
23renal agenesis10.3
24dysgerminoma10.3CGA, AFP
25urinary tract obstruction10.3ACE, AQP3
26chorioamnionitis10.3SERPINH1, OXT
27ovarian hyperstimulation syndrome10.3REN, CGA
28hypertension, diastolic10.2REN, ACE
29cervicitis10.2
30preterm premature rupture of the membranes10.2
31septic shock10.2ADM, OXT, NPPB
32pure autonomic failure10.2REN, ACE
33gitelman syndrome10.2REN, AGT
34choriocarcinoma10.2AFP, ADM, OXT, CGA
35meconium aspiration syndrome10.2EDN1, OXT
36hepatorenal syndrome10.2EDN1, REN
37cleft palate10.1
38twin-to-twin transfusion syndrome10.1
39cerebritis10.1
40bilateral renal agenesis dominant type10.1
41twin twin transfusion syndrome10.1
42cytomegalovirus infection10.1
43malignant hypertension10.1ADM, REN, ACE
44kawasaki disease10.1NPPB, ADM
45aortic valve stenosis10.1AGT, NPPB
46polycystic kidney disease, autosomal dominant10.1AQP1, REN, ACE
47hydrocephalus10.1AQP1, AFP
48adrenal adenoma10.1ADM, REN
49diabetic angiopathy10.1EDN1, NAGLU, ADM
50glomerulonephritis10.1AGTR1, NAGLU, SERPINH1

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to oligohydramnios

Symptoms for Oligohydramnios

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Drugs & Therapeutics for Oligohydramnios

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Drug clinical trials:

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Genetic Tests for Oligohydramnios

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Anatomical Context for Oligohydramnios

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MalaCards organs/tissues related to Oligohydramnios:

32
Lung, Placenta, Kidney, Fetal lung, Heart, Brain, Bone, Spinal cord, Breast, Skin, Testes, Cervix, Trachea

Animal Models for Oligohydramnios or affiliated genes

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MGI Mouse Phenotypes related to Oligohydramnios:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9SERPINH1, AQP1, NAGLU, OXT, REN, AGT
2MP:00053867.7AFP, AQP3, AQP1, NAGLU, ADM, OXT
3MP:00053817.7EDN1, SERPINH1, AQP3, AQP8, OXT, TREH
4MP:00053797.4EDN1, AFP, AQP8, AQP1, OXT, ACE
5MP:00053787.3SERPINH1, AQP3, AQP1, NAGLU, OXT, REN
6MP:00053897.2AFP, AQP8, AQP1, ADM, OXT, REN
7MP:00107686.8AQP1, AQP3, SERPINH1, AFP, EDN1, NAGLU
8MP:00053856.8NAGLU, AQP1, AQP3, SERPINH1, EDN1, ADM
9MP:00053676.3TREH, EDN1, AQP3, AQP8, AQP1, NAGLU
10MP:00053766.0AQP1, AQP8, AQP3, AFP, EDN1, ADM

Publications for Oligohydramnios

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Articles related to Oligohydramnios:

(show top 50)    (show all 420)
idTitleAuthorsYear
1
Intra-vaginal prostaglandin E2 versus double-balloon catheter for labor induction in term oligohydramnios. (25275693)
2014
2
Which is the safer method of labor induction for oligohydramnios women? Transcervical double balloon catheter or dinoprostone vaginal insert. (24397441)
2014
3
The association between isolated oligohydramnios at term and pregnancy outcome. (24925346)
2014
4
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
5
Oligohydramnios associated with sonographically normal kidneys. (22088568)
2012
6
Short-term outcome among term singleton infants with intrapartum oligohydramnios. (22404314)
2012
7
Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios. (19194718)
2009
8
Contemporary neonatal outcome following rupture of membranes prior to 25 weeks with prolonged oligohydramnios. (19108959)
2009
9
Herceptin (trastuzumab) therapy in a twin pregnancy with associated oligohydramnios. (19398090)
2009
10
Earlier gestational age at ultrasound evaluation predicts adverse neonatal outcomes in the preterm appropriate-for-gestational-age fetus with idiopathic oligohydramnios. (18843586)
2009
11
Intrapartum fetal heart rate pattern in oligohydramnios. (18765941)
2008
12
Intrauterine growth restriction and oligohydramnios among high-risk patients. (17447191)
2007
13
Isolated oligohydramnios in term pregnancy as an indication for induction of labor. (17437223)
2007
14
A randomized clinical trial comparing the effect of maternal intravenous hydration and placebo on the amniotic fluid index in oligohydramnios. (17763271)
2007
15
A review of amniotic fluid dynamics and the enigma of isolated oligohydramnios. (12152144)
2002
16
Lack of relationship between variable decelerations during reactive nonstress tests and oligohydramnios. (11414522)
2001
17
Successful enucleation of a necrotizing fibroid causing oligohydramnios and fetal postural deformity in the 25th week of gestation. A case report. (11725739)
2001
18
Role of maternal oral hydration in increasing amniotic fluid volume in pregnant women with oligohydramnios. (11336736)
2001
19
A digynic triploid fetus presenting with intrauterine growth restriction, severe oligohydramnios and relative macrocephaly on prenatal ultrasound. (11169300)
2000
20
Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. (11094215)
2000
21
Acute oligohydramnios and deteriorating fetal biophysical profile associated with severe preeclampsia. (10406305)
1999
22
Effect of maternal hydration on oligohydramnios: a comparison of three volume expansion methods. (9764623)
1998
23
Oligohydramnios: sonographic diagnosis and clinical implications. (9199843)
1997
24
Is fetal thoracic compression really the underlying mechanism of lung hypoplasia in oligohydramnios? An experimental study in a rabbit model. (9165252)
1997
25
Prophylactic transabdominal amnioinfusion in oligohydramnios for preterm premature rupture of membranes: increase of amniotic fluid index during latency period. (9415523)
1997
26
Oligohydramnios with amnio-chorionic separation at 15-16 weeks' gestation. (7784368)
1995
27
Transabdominal amnioinfusion in preterm pregnancies complicated by fetal growth restriction, oligohydramnios and umbilical cord compression. (8579780)
1995
28
Acute maternal hydration in third-trimester oligohydramnios: effects on amniotic fluid volume, uteroplacental perfusion, and fetal blood flow and urine output. (7485317)
1995
29
Effects of intracervical prostaglandin E2 on fetal heart rate and uterine activity patterns in the presence of oligohydramnios. (7485313)
1995
30
Oligohydramnios: problems and treatment. (7690990)
1993
31
Transabdominal amnioinfusion for the management of nonlaboring postdates with severe oligohydramnios. (8286032)
1993
32
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
33
Long bone development in extrinsic fetal akinesia: an experimental study in rat fetuses subjected to oligohydramnios. (1641814)
1992
34
Late onset severe oligohydramnios associated with genitourinary abnormalities. (1640513)
1992
35
The natural history of oligohydramnios/polyhydramnios sequence in monochorionic diamniotic twins. (12796928)
1992
36
The influence of experimentally produced oligohydramnios on lung growth and pulmonary surfactant content in fetal rabbits. (1812157)
1991
37
Fetal vesicorectal fistula causing oligohydramnios in the second trimester. Case report. (2372530)
1990
38
Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use. (2301491)
1990
39
Oligohydramnios. (2810473)
1989
40
Sonography of placental abnormalities and oligohydramnios in women with elevated alpha-fetoprotein levels: comparison with control subjects. (2476009)
1989
41
Fetal breathing movements as predictor of favourable pregnancy outcome after oligohydramnios due to membrane rupture in second trimester. (2885600)
1987
42
Congenital cutis laxa syndrome: relation of joint dislocations to oligohydramnios. (3777971)
1986
43
Ultrasound evaluation of amniotic fluid: outcome of pregnancies with severe oligohydramnios. (3515948)
1986
44
Neonatal pulmonary hypoplasia with premature rupture of fetal membranes and oligohydramnios. (4040564)
1985
45
Ultrasound-detected oligohydramnios and fetal outcome. (6731530)
1984
46
Abdominal dynamic study in oligohydramnios with Potter's syndrome. (6370698)
1984
47
Elevated maternal serum alpha-fetoprotein, second-trimester oligohydramnios, and pregnancy outcome. (6192373)
1983
48
Oligohydramnios is a contraindication to amniocentesis. (6102258)
1980
49
Oligohydramnios syndrome and intra-abdominal pregnancy. (830883)
1977
50
Renal agenesis, oligohydramnios and diabetes mellitus. (4891577)
1969

Variations for Oligohydramnios

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Expression for genes affiliated with Oligohydramnios

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Expression patterns in normal tissues for genes affiliated with Oligohydramnios

Search GEO for disease gene expression data for Oligohydramnios.

Pathways for genes affiliated with Oligohydramnios

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Pathways related to Oligohydramnios according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AGT, EDN1
29.6ADM, GPR182
39.4AGT, NPPB, EDN1
4
Show member pathways
9.2AQP1, AQP8, AQP3
5
Show member pathways
9.1REN, ACE, AGT, CGA
6
Show member pathways
9.0AGTR1, AGT, ACE, REN
7
Show member pathways
9.0REN, ACE, AGT, AGTR1
8
Show member pathways
8.8EDN1, OXT, AGT, AGTR1
9
Show member pathways
8.3EDN1, ADM, OXT, AGT, AGTR1, CGA

Compounds for genes affiliated with Oligohydramnios

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Compounds related to Oligohydramnios according to GeneCards/GeneDecks:

(show top 50)    (show all 216)
idCompoundScoreTop Affiliating Genes
1aliskiren44 1110.4AGT, AGTR1, ACE, REN
2omapatrilat449.3ACE, REN, ADM, EDN1
3saralasin449.3AGT, REN, ACE, AGTR1
4lacidipine449.3EDN1, AGTR1, REN, ACE
5eprosartan44 28 1111.3AGTR1, AGT, ACE, REN
6cilazapril44 1110.2EDN1, REN, AGTR1, ACE
7olmesartan44 28 1111.1AGT, AGTR1, ACE, REN
8fosinopril44 1110.1AGTR1, ACE, NPPB, REN
9lisinopril44 50 24 1112.1ACE, REN, NPPB, AGT, AGTR1
10telmisartan44 28 1111.0NPPB, REN, ACE, AGT, AGTR1
11enalaprilat449.0AGT, EDN1, REN, ACE, NPPB
12trandolapril44 1110.0EDN1, AGTR1, REN, ACE, NPPB
13benazepril44 50 1111.0REN, AGTR1, AGT, ACE
14candesartan44 50 28 1112.0REN, AGT, NPPB, ACE, AGTR1
15amlodipine44 50 24 1112.0REN, ACE, AGT, AGTR1, NPPB
16mannitol44 1110.0AQP1, OXT, CGA, ADM, NAGLU, AQP3
17furosemide44 61 28 50 24 1114.0REN, ACE, AGTR1, NAGLU, NPPB
18chymostatin449.0EDN1, REN, AGT, ACE, AGTR1
19irbesartan44 28 50 1111.9REN, ACE, AGTR1, AGT, EDN1
20diltiazem44 28 50 1111.9AGTR1, AGT, EDN1, REN, ACE
21perindopril44 50 1110.9AGT, AGTR1, NPPB, ACE, REN, NAGLU
22carvedilol44 50 28 1111.8REN, AGTR1, ADM, ACE, EDN1, NPPB
23valsartan44 61 28 1111.7NPPB, REN, AGTR1, AGT, ACE, EDN1
24atenolol44 50 28 24 1112.7EDN1, REN, ACE, NPPB, AGTR1, AGT
25sodium nitroprusside448.7CGA, EDN1, NPPB, AGTR1, AQP1, ADM
26l-nmma448.7EDN1, AGTR1, ADM, AGT, NPPB
27quinapril44 50 1110.6REN, AGTR1, EDN1, ACE
28verapamil44 28 50 24 1112.6AGTR1, CGA, ACE, REN, NAGLU, EDN1
29cgmp44 289.6REN, ADM, AGT, AGTR1, NPPB, EDN1
30enalapril44 50 1110.5NAGLU, REN, ACE, NPPB, AGT, AGTR1
31captopril44 61 50 28 1112.5EDN1, AGTR1, REN, NPPB, ACE, ADM
32ang ii448.5AGTR1, AGT, NPPB, EDN1, ADM, REN
33potassium44 24 1110.4REN, ACE, ADM, NAGLU, AQP1, AGTR1
34phenylephrine44 28 24 1111.4CGA, AGTR1, AGT, NPPB, ADM, EDN1
35cyclosporin a44 28 6110.3ADM, NAGLU, EDN1, CGA, AGTR1, SERPINH1
36nitroglycerin44 119.3AGTR1, NPPB, ACE, REN, OXT, ADM
37losartan44 50 28 1111.3REN, NPPB, AGTR1, AGT, ACE, ADM
38nifedipine44 28 50 1111.3AGTR1, EDN1, NAGLU, OXT, REN, ACE
39prostacyclin448.1AGTR1, ADM, REN, NPPB, AGT, CGA
40steroid448.1NPPB, CGA, AGT, REN, OXT, ADM
41acetylcholine44 50 28 24 1112.0EDN1, ADM, CGA, AGTR1, AGT, ACE
42epinephrine44 24 119.9CGA, AGTR1, AGT, NPPB, REN, OXT
43sodium44 248.8AQP1, EDN1, AFP, NAGLU, ADM, REN
44glucose447.7AFP, AQP1, ADM, REN, ACE, AQP3
45arginine447.6EDN1, AQP1, OXT, REN, NPPB, AGT
46norepinephrine44 24 119.6OXT, REN, ACE, NPPB, AGT, AGTR1
47vegf447.4CGA, AGTR1, AGT, NPPB, EDN1, AFP
48forskolin44 50 119.2AGT, CGA, NPPB, REN, OXT, AQP8
49nitric oxide44 24 119.2AGT, ADM, ACE, REN, OXT, NPPB
50creatinine446.8AGTR1, CGA, AGT, OXT, ADM, NAGLU

GO Terms for genes affiliated with Oligohydramnios

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Cellular components related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.1ADM, OXT, REN, ACE, NPPB, HHLA1
2extracellular spaceGO:0056156.9AGT, EDN1, AFP, SERPINH1, ADM, OXT

Biological processes related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.2NPPB, AQP1
2nitric oxide transportGO:03018510.2EDN1, AQP1
3positive regulation of NAD(P)H oxidase activityGO:03386410.1AGT, AGTR1
4regulation of blood vessel size by renin-angiotensinGO:00203410.1AGT, AGTR1
5regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
6positive regulation of cholesterol esterificationGO:01087310.1AGT, AGTR1
7regulation of renal output by angiotensinGO:00201910.1AGT, ACE
8positive regulation of heart rateGO:01046010.0EDN1, ADM
9body fluid secretionGO:00758910.0EDN1, NPPB
10artery smooth muscle contractionGO:01482410.0AGT, EDN1
11low-density lipoprotein particle remodelingGO:03437410.0AGTR1, AGT
12positive regulation of cellular protein metabolic processGO:03227010.0AGT, AGTR1
13positive regulation of cardiac muscle hypertrophyGO:01061310.0AGT, EDN1
14regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.0ACE, AGTR1
15drinking behaviorGO:04275610.0REN, OXT
16positive regulation of urine volumeGO:0358109.9EDN1, NPPB
17positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:0514829.9AGTR1, EDN1
18positive regulation of macrophage derived foam cell differentiationGO:0107449.9AGTR1, AGT
19renin-angiotensin regulation of aldosterone productionGO:0020189.9AGTR1, AGT, REN
20angiotensin maturationGO:0020039.8AGT, ACE, REN
21regulation of blood pressureGO:0082179.7NPPB, ACE, REN
22positive regulation of synapse assemblyGO:0519659.7SRPX2, OXT
23regulation of vasodilationGO:0423129.7ACE, NPPB, AGTR1
24response to lipopolysaccharideGO:0324969.7REN, ADM, EDN1
25middle ear morphogenesisGO:0424749.6NAGLU, EDN1
26water transportGO:0068339.6AQP3, AQP8, AQP1
27regulation of sensory perception of painGO:0519309.5OXT, EDN1
28cell-cell signalingGO:0072679.5EDN1, ADM, AGT, CGA
29kidney developmentGO:0018229.4REN, ACE, AGT, AGTR1
30heart developmentGO:0075079.4EDN1, ADM, OXT
31positive regulation of cytosolic calcium ion concentrationGO:0072049.3EDN1, ADM, OXT, AGTR1
32regulation of vasoconstrictionGO:0192299.3EDN1, ACE, AGT, AGTR1
33positive regulation of renal sodium excretionGO:0358159.3AGT, NPPB, OXT, EDN1
34cell surface receptor signaling pathwayGO:0071669.0EDN1, GPR182, NPPB

Molecular functions related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.4NPPB, SRPX2, REN, ADM
2bradykinin receptor bindingGO:0317119.3AGTR1, ACE
3water channel activityGO:0152509.1AQP3, AQP8, AQP1
4hormone activityGO:0051798.9CGA, AGT, NPPB, ADM, EDN1

Products for genes affiliated with Oligohydramnios

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Sources for Oligohydramnios

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet