MCID: OLG003
MIFTS: 59

Oligohydramnios malady

Fetal diseases category
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Summaries for Oligohydramnios

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards: Oligohydramnios, also known as oligohydramnios - delivered, is related to polyhydramnios and renal tubular dysgenesis. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Physiological and Pathological Hypertrophy of the Heart and Sympathetic Nerve Pathway (Neuroeffector Junction). The compounds aliskiren and omapatrilat have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and fetal lung, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:65 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Aliases & Classifications for Oligohydramnios

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

oligohydramnios 8 10 45 62
oligohydramnios - delivered 8 62
oligohydramnios, antepartum 62
antepartum oligohydramnios 8
delivered oligohydramnios 8


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Disease Ontology8 DOID:12215
ICD9CM27 658.0
MeSH35 D016104
ICD1025 O41.0

Related Diseases for Oligohydramnios

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17GeneCards, 18GeneDecks
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Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios31.0AFP, AQP1, OXT
2renal tubular dysgenesis30.4REN, AGT, AGTR1
3diabetes insipidus30.0OXT
4placental abruption30.0SERPINH1, AFP
5diabetes mellitus29.5EDN1, NAGLU, REN, ACE, NPPB, AGT
6pre-eclampsia29.5EDN1, AFP, NAGLU, ADM, OXT, REN
7hypertension29.5EDN1, ADM, REN, ACE, NPPB, AGT
8potter's syndrome10.5
9renal agenesis10.3
10cervicitis10.2
11preterm premature rupture of the membranes10.2
12cleft palate10.1
13cerebritis10.1
14bilateral renal agenesis dominant type10.1
15cytomegalovirus infection10.1
16endodermal sinus tumor10.1AFP
17fibromuscular dysplasia10.1REN
18congestive heart failure10.1REN
19hypoaldosteronism10.1REN
20male germ cell tumor, somatic10.1AFP, CGA
21nephrogenic diabetes insipidus10.1AQP1, OXT
22edwards syndrome10.1CGA, AFP
23anencephaly10.1AFP, CGA
24germinoma10.1AFP, CGA
25germ cell cancer10.1AFP, CGA
26endometritis10.1SERPINH1, OXT
27mitral valve prolapse10.1AGTR1
28lipoid nephrosis10.1NAGLU, ADM
29borderline personality disorder10.1OXT, CGA
30dysgerminoma10.1CGA, AFP
31urinary tract obstruction10.1ACE, AQP3
32chorioamnionitis10.1SERPINH1, OXT
33ovarian hyperstimulation syndrome10.1REN, CGA
34hypertension, diastolic10.1REN, ACE
35anuria10.0
36polydactyly10.0
37twin-to-twin transfusion syndrome10.0
38gastroschisis10.0
39meckel syndrome10.0
40congenital cytomegalovirus10.0
41hydrops fetalis10.0
42potter syndrome type 110.0
43twin twin transfusion syndrome10.0
44renal dysplasia10.0
45septic shock10.0ADM, OXT, NPPB
46pure autonomic failure10.0REN, ACE
47gitelman syndrome10.0REN, AGT
48choriocarcinoma10.0AFP, ADM, OXT, CGA
49meconium aspiration syndrome10.0EDN1, OXT
50hepatorenal syndrome10.0EDN1, REN

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to oligohydramnios

Symptoms for Oligohydramnios

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Drugs & Therapeutics for Oligohydramnios

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Oligohydramnios

Search NIH Clinical Center for Oligohydramnios

Genetic Tests for Oligohydramnios

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Anatomical Context for Oligohydramnios

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33MalaCards
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MalaCards organs/tissues related to Oligohydramnios:

33
Lung, Placenta, Fetal lung, Kidney, Heart, Brain, Testes, Breast, Bone, Spinal cord, Trachea

Animal Models for Oligohydramnios or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Oligohydramnios:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9SERPINH1, AQP1, NAGLU, OXT, REN, AGT
2MP:00053867.7AFP, AQP3, AQP1, NAGLU, ADM, OXT
3MP:00053817.7EDN1, SERPINH1, AQP3, AQP8, OXT, TREH
4MP:00053797.4EDN1, AFP, AQP8, AQP1, OXT, ACE
5MP:00053787.3SERPINH1, AQP3, AQP1, NAGLU, OXT, REN
6MP:00053897.2AFP, AQP8, AQP1, ADM, OXT, REN
7MP:00107686.8AQP1, AQP3, SERPINH1, AFP, EDN1, NAGLU
8MP:00053856.8NAGLU, AQP1, AQP3, SERPINH1, EDN1, ADM
9MP:00053676.3TREH, EDN1, AQP3, AQP8, AQP1, NAGLU
10MP:00053766.0AQP1, AQP8, AQP3, AFP, EDN1, ADM

Publications for Oligohydramnios

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52PubMed
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Articles related to Oligohydramnios:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
Which is the safer method of labor induction for oligohydramnios women? Transcervical double balloon catheter or dinoprostone vaginal insert. (24397441)
2014
2
Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. (22872543)
2013
3
Oligohydramnios associated with sonographically normal kidneys. (22088568)
2012
4
Short-term outcome among term singleton infants with intrapartum oligohydramnios. (22404314)
2012
5
Spontaneous antepartum vesicouterine fistula causing severe oligohydramnios in a patient with a previous cesarean delivery. (22837297)
2012
6
Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios. (19194718)
2009
7
Contemporary neonatal outcome following rupture of membranes prior to 25 weeks with prolonged oligohydramnios. (19108959)
2009
8
Herceptin (trastuzumab) therapy in a twin pregnancy with associated oligohydramnios. (19398090)
2009
9
Earlier gestational age at ultrasound evaluation predicts adverse neonatal outcomes in the preterm appropriate-for-gestational-age fetus with idiopathic oligohydramnios. (18843586)
2009
10
Intrapartum fetal heart rate pattern in oligohydramnios. (18765941)
2008
11
Intrauterine growth restriction and oligohydramnios among high-risk patients. (17447191)
2007
12
Isolated oligohydramnios in term pregnancy as an indication for induction of labor. (17437223)
2007
13
A randomized clinical trial comparing the effect of maternal intravenous hydration and placebo on the amniotic fluid index in oligohydramnios. (17763271)
2007
14
Paris heat wave and oligohydramnios. (15592298)
2004
15
A review of amniotic fluid dynamics and the enigma of isolated oligohydramnios. (12152144)
2002
16
Lack of relationship between variable decelerations during reactive nonstress tests and oligohydramnios. (11414522)
2001
17
Successful enucleation of a necrotizing fibroid causing oligohydramnios and fetal postural deformity in the 25th week of gestation. A case report. (11725739)
2001
18
Role of maternal oral hydration in increasing amniotic fluid volume in pregnant women with oligohydramnios. (11336736)
2001
19
A digynic triploid fetus presenting with intrauterine growth restriction, severe oligohydramnios and relative macrocephaly on prenatal ultrasound. (11169300)
2000
20
Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. (11094215)
2000
21
Acute oligohydramnios and deteriorating fetal biophysical profile associated with severe preeclampsia. (10406305)
1999
22
Effect of maternal hydration on oligohydramnios: a comparison of three volume expansion methods. (9764623)
1998
23
Oligohydramnios: sonographic diagnosis and clinical implications. (9199843)
1997
24
Is fetal thoracic compression really the underlying mechanism of lung hypoplasia in oligohydramnios? An experimental study in a rabbit model. (9165252)
1997
25
Prophylactic transabdominal amnioinfusion in oligohydramnios for preterm premature rupture of membranes: increase of amniotic fluid index during latency period. (9415523)
1997
26
Oligohydramnios with amnio-chorionic separation at 15-16 weeks' gestation. (7784368)
1995
27
Transabdominal amnioinfusion in preterm pregnancies complicated by fetal growth restriction, oligohydramnios and umbilical cord compression. (8579780)
1995
28
Acute maternal hydration in third-trimester oligohydramnios: effects on amniotic fluid volume, uteroplacental perfusion, and fetal blood flow and urine output. (7485317)
1995
29
Effects of intracervical prostaglandin E2 on fetal heart rate and uterine activity patterns in the presence of oligohydramnios. (7485313)
1995
30
Is oligohydramnios a risk factor for infection in term premature rupture of membranes? (12797200)
1994
31
Oligohydramnios: problems and treatment. (7690990)
1993
32
Transabdominal amnioinfusion for the management of nonlaboring postdates with severe oligohydramnios. (8286032)
1993
33
Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies complicated by polyhydramnios and oligohydramnios. (8459967)
1993
34
Long bone development in extrinsic fetal akinesia: an experimental study in rat fetuses subjected to oligohydramnios. (1641814)
1992
35
Late onset severe oligohydramnios associated with genitourinary abnormalities. (1640513)
1992
36
The natural history of oligohydramnios/polyhydramnios sequence in monochorionic diamniotic twins. (12796928)
1992
37
The influence of experimentally produced oligohydramnios on lung growth and pulmonary surfactant content in fetal rabbits. (1812157)
1991
38
Fetal vesicorectal fistula causing oligohydramnios in the second trimester. Case report. (2372530)
1990
39
Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use. (2301491)
1990
40
Oligohydramnios. (2810473)
1989
41
Sonography of placental abnormalities and oligohydramnios in women with elevated alpha-fetoprotein levels: comparison with control subjects. (2476009)
1989
42
Fetal breathing movements as predictor of favourable pregnancy outcome after oligohydramnios due to membrane rupture in second trimester. (2885600)
1987
43
Ultrasound evaluation of amniotic fluid: outcome of pregnancies with severe oligohydramnios. (3515948)
1986
44
Neonatal pulmonary hypoplasia with premature rupture of fetal membranes and oligohydramnios. (4040564)
1985
45
Ultrasound-detected oligohydramnios and fetal outcome. (6731530)
1984
46
Abdominal dynamic study in oligohydramnios with Potter's syndrome. (6370698)
1984
47
Elevated maternal serum alpha-fetoprotein, second-trimester oligohydramnios, and pregnancy outcome. (6192373)
1983
48
Oligohydramnios is a contraindication to amniocentesis. (6102258)
1980
49
Oligohydramnios syndrome and intra-abdominal pregnancy. (830883)
1977
50
Renal agenesis, oligohydramnios and diabetes mellitus. (4891577)
1969

Variations for Oligohydramnios

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Expression for genes affiliated with Oligohydramnios

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligohydramnios

Search GEO for disease gene expression data for Oligohydramnios.

Pathways for genes affiliated with Oligohydramnios

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 60Thomson Reuters, 30KEGG, 53QIAGEN
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Pathways related to Oligohydramnios according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AGT, EDN1
29.6ADM, GPR182
39.4AGT, NPPB, EDN1
4
Show member pathways
9.2AQP1, AQP8, AQP3
5
Show member pathways
9.1REN, ACE, AGT, CGA
6
Show member pathways
9.0AGTR1, AGT, ACE, REN
7
Show member pathways
9.0REN, ACE, AGT, AGTR1
8
Show member pathways
8.8EDN1, OXT, AGT, AGTR1
9
Show member pathways
8.3EDN1, ADM, OXT, AGT, AGTR1, CGA

Compounds for genes affiliated with Oligohydramnios

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Oligohydramnios according to GeneCards/GeneDecks:

(show top 50)    (show all 216)
idCompoundScoreTop Affiliating Genes
1aliskiren45 1110.4AGT, AGTR1, ACE, REN
2omapatrilat459.3ACE, REN, ADM, EDN1
3saralasin459.3AGT, REN, ACE, AGTR1
4lacidipine459.3EDN1, AGTR1, REN, ACE
5eprosartan45 29 1111.3AGTR1, AGT, ACE, REN
6cilazapril45 1110.2EDN1, REN, AGTR1, ACE
7olmesartan45 29 1111.1AGT, AGTR1, ACE, REN
8fosinopril45 1110.1AGTR1, ACE, NPPB, REN
9lisinopril45 51 24 1112.1ACE, REN, NPPB, AGT, AGTR1
10telmisartan45 29 1111.0NPPB, REN, ACE, AGT, AGTR1
11enalaprilat459.0AGT, EDN1, REN, ACE, NPPB
12trandolapril45 1110.0EDN1, AGTR1, REN, ACE, NPPB
13benazepril45 51 1111.0REN, AGTR1, AGT, ACE
14candesartan45 51 29 1112.0REN, AGT, NPPB, ACE, AGTR1
15amlodipine45 51 24 1112.0REN, ACE, AGT, AGTR1, NPPB
16mannitol45 1110.0AQP1, OXT, CGA, ADM, NAGLU, AQP3
17furosemide45 61 29 51 24 1114.0REN, ACE, AGTR1, NAGLU, NPPB
18chymostatin459.0EDN1, REN, AGT, ACE, AGTR1
19irbesartan45 29 51 1111.9REN, ACE, AGTR1, AGT, EDN1
20diltiazem45 29 51 1111.9AGTR1, AGT, EDN1, REN, ACE
21perindopril45 51 1110.9AGT, AGTR1, NPPB, ACE, REN, NAGLU
22carvedilol45 51 29 1111.8REN, AGTR1, ADM, ACE, EDN1, NPPB
23valsartan45 61 29 1111.7NPPB, REN, AGTR1, AGT, ACE, EDN1
24atenolol45 51 29 24 1112.7EDN1, REN, ACE, NPPB, AGTR1, AGT
25sodium nitroprusside458.7CGA, EDN1, NPPB, AGTR1, AQP1, ADM
26l-nmma458.7EDN1, AGTR1, ADM, AGT, NPPB
27quinapril45 51 1110.6REN, AGTR1, EDN1, ACE
28verapamil45 29 51 24 1112.6AGTR1, CGA, ACE, REN, NAGLU, EDN1
29cgmp45 299.6REN, ADM, AGT, AGTR1, NPPB, EDN1
30enalapril45 51 1110.5NAGLU, REN, ACE, NPPB, AGT, AGTR1
31captopril45 61 51 29 1112.5EDN1, AGTR1, REN, NPPB, ACE, ADM
32ang ii458.5AGTR1, AGT, NPPB, EDN1, ADM, REN
33potassium45 24 1110.4REN, ACE, ADM, NAGLU, AQP1, AGTR1
34phenylephrine45 29 24 1111.4CGA, AGTR1, AGT, NPPB, ADM, EDN1
35cyclosporin a45 29 6110.3ADM, NAGLU, EDN1, CGA, AGTR1, SERPINH1
36nitroglycerin45 119.3AGTR1, NPPB, ACE, REN, OXT, ADM
37losartan45 51 29 1111.3REN, NPPB, AGTR1, AGT, ACE, ADM
38nifedipine45 29 51 1111.3AGTR1, EDN1, NAGLU, OXT, REN, ACE
39prostacyclin458.1AGTR1, ADM, REN, NPPB, AGT, CGA
40steroid458.1NPPB, CGA, AGT, REN, OXT, ADM
41acetylcholine45 51 29 24 1112.0EDN1, ADM, CGA, AGTR1, AGT, ACE
42epinephrine45 24 119.9CGA, AGTR1, AGT, NPPB, REN, OXT
43sodium45 248.8AQP1, EDN1, AFP, NAGLU, ADM, REN
44glucose457.7AFP, AQP1, ADM, REN, ACE, AQP3
45arginine457.6EDN1, AQP1, OXT, REN, NPPB, AGT
46norepinephrine45 24 119.6OXT, REN, ACE, NPPB, AGT, AGTR1
47vegf457.4CGA, AGTR1, AGT, NPPB, EDN1, AFP
48forskolin45 51 119.2AGT, CGA, NPPB, REN, OXT, AQP8
49nitric oxide45 24 119.2AGT, ADM, ACE, REN, OXT, NPPB
50creatinine456.8AGTR1, CGA, AGT, OXT, ADM, NAGLU

GO Terms for genes affiliated with Oligohydramnios

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16Gene Ontology
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Cellular components related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.1ADM, OXT, REN, ACE, NPPB, HHLA1
2extracellular spaceGO:0056156.9AGT, EDN1, AFP, SERPINH1, ADM, OXT

Biological processes related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.2NPPB, AQP1
2nitric oxide transportGO:03018510.2EDN1, AQP1
3positive regulation of NAD(P)H oxidase activityGO:03386410.1AGT, AGTR1
4regulation of blood vessel size by renin-angiotensinGO:00203410.1AGT, AGTR1
5regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
6positive regulation of cholesterol esterificationGO:01087310.1AGT, AGTR1
7regulation of renal output by angiotensinGO:00201910.1AGT, ACE
8positive regulation of heart rateGO:01046010.0EDN1, ADM
9body fluid secretionGO:00758910.0EDN1, NPPB
10artery smooth muscle contractionGO:01482410.0AGT, EDN1
11low-density lipoprotein particle remodelingGO:03437410.0AGTR1, AGT
12positive regulation of cellular protein metabolic processGO:03227010.0AGT, AGTR1
13positive regulation of cardiac muscle hypertrophyGO:01061310.0AGT, EDN1
14regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.0ACE, AGTR1
15drinking behaviorGO:04275610.0REN, OXT
16positive regulation of urine volumeGO:0358109.9EDN1, NPPB
17positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:0514829.9AGTR1, EDN1
18positive regulation of macrophage derived foam cell differentiationGO:0107449.9AGTR1, AGT
19renin-angiotensin regulation of aldosterone productionGO:0020189.9AGTR1, AGT, REN
20angiotensin maturationGO:0020039.8AGT, ACE, REN
21regulation of blood pressureGO:0082179.7NPPB, ACE, REN
22positive regulation of synapse assemblyGO:0519659.7SRPX2, OXT
23regulation of vasodilationGO:0423129.7ACE, NPPB, AGTR1
24response to lipopolysaccharideGO:0324969.7REN, ADM, EDN1
25middle ear morphogenesisGO:0424749.6NAGLU, EDN1
26water transportGO:0068339.6AQP3, AQP8, AQP1
27regulation of sensory perception of painGO:0519309.5OXT, EDN1
28cell-cell signalingGO:0072679.5EDN1, ADM, AGT, CGA
29kidney developmentGO:0018229.4REN, ACE, AGT, AGTR1
30heart developmentGO:0075079.4EDN1, ADM, OXT
31positive regulation of cytosolic calcium ion concentrationGO:0072049.3EDN1, ADM, OXT, AGTR1
32regulation of vasoconstrictionGO:0192299.3EDN1, ACE, AGT, AGTR1
33positive regulation of renal sodium excretionGO:0358159.3AGT, NPPB, OXT, EDN1
34cell surface receptor signaling pathwayGO:0071669.0EDN1, GPR182, NPPB

Molecular functions related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.4NPPB, SRPX2, REN, ADM
2bradykinin receptor bindingGO:0317119.3AGTR1, ACE
3water channel activityGO:0152509.1AQP3, AQP8, AQP1
4hormone activityGO:0051798.9CGA, AGT, NPPB, ADM, EDN1

Products for genes affiliated with Oligohydramnios

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  • Antibodies
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Sources for Oligohydramnios

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet