MCID: OLG003
MIFTS: 45

Oligohydramnios malady

Summaries for Oligohydramnios

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

MalaCards: Oligohydramnios, also known as oligohydramnios - delivered, is related to polyhydramnios and gastroschisis. An important gene associated with Oligohydramnios is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Calcium channels and Presynaptic nicotinic acetylcholine receptors. The compounds gemeprost and diatrizoate have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and renal/urinary system.

Wikipedia:64 Oligohydramnios is a condition in pregnancy characterized by a deficiency of amniotic fluid. It is the... more...

Aliases & Classifications for Oligohydramnios

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

oligohydramnios 8 10 45 61
oligohydramnios - delivered 8 61
oligohydramnios, antepartum 61
antepartum oligohydramnios 8
delivered oligohydramnios 8


External Ids:

Disease Ontology8 DOID:12215
ICD9CM27 658.0
MeSH35 D016104
ICD1025 O41.0

Related Diseases for Oligohydramnios

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Oligohydramnios via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.8AFP, OXT, AQP1
2gastroschisis30.0AFP
3diabetes insipidus29.8OXT
4potter's syndrome10.5
5renal agenesis10.3
6n syndrome10.3
7renal tubular dysgenesis10.2
8cleft palate10.1
9bilateral renal agenesis dominant type10.1
10twin twin transfusion syndrome10.1
11cytomegalovirus infection10.1
12renal dysplasia10.1
13anuria10.0
14polydactyly10.0
15meckel syndrome10.0
16congenital cytomegalovirus10.0
17hydrops fetalis10.0
18potter syndrome type 110.0
19renal dysplasia, cystic10.0
20renal hypoplasia10.0
21vesicoureteral reflux10.0NAGLU
22pyelonephritis10.0NAGLU
23peritonitis10.0AQP1
24primary hyperoxaluria10.0AQP1
25urinary tract obstruction10.0AQP3
26hypertension10.0ADM
27myasthenic syndrome, fast-channel congenital10.0CHRND, CHRNA1
28slow-channel congenital myasthenic syndrome10.0CHRND, CHRNA1
29edwards syndrome10.0AFP
30renal hypertension10.0GPR182, ADM
31chorioamnionitis10.0OXT, SERPINH1
32diabetic angiopathy10.0ADM, NAGLU
33cystic lymphangioma10.0CHRNG, AFP, CHRND
34nephrogenic diabetes insipidus10.0OXT, AQP1
35congenital myasthenic syndrome10.0CHRNA1, CHRND
36leiomyoma10.0ADM
37nephrotic syndrome10.0NAGLU, TREH, AQP3
38lipoid nephrosis10.0ADM, NAGLU
39multiple pterygium syndrome lethal type10.0CHRNG, CHRND, CHRNA1
40liver cirrhosis10.0ADM, AFP
41idiopathic edema10.0AQP1, ADM
42pre-eclampsia10.0ADM, NAGLU, OXT, AFP
43glomerulonephritis10.0NAGLU, SERPINH1
44choriocarcinoma10.0OXT, ADM, AFP
45neurofibromatosis9.9
46cutis laxa9.9
47larsen syndrome9.9
48twin-to-twin transfusion syndrome9.9
49eclampsia9.9
50newborn respiratory distress syndrome9.9

Graphical network of the top 20 diseases related to Oligohydramnios:



Diseases related to oligohydramnios

Clinical Features for Oligohydramnios

Drugs & Therapeutics for Oligohydramnios

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Oligohydramnios

Drug clinical trials:

Search ClinicalTrials for Oligohydramnios

Search NIH Clinical Center for Oligohydramnios

Search CenterWatch for Oligohydramnios

Genetic Tests for Oligohydramnios

Anatomical Context for Oligohydramnios

Animal Models for Oligohydramnios or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Oligohydramnios:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.6AFP, CHRNG, CHRNA1, OXT, NAGLU, SERPINH1
2MP:00053678.6TREH, OXT, NAGLU, ADM, AQP1, AQP3

Publications for Oligohydramnios

Sources:
51PubMed
See all sources

Articles related to Oligohydramnios:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Perinatal outcomes of isolated oligohydramnios at term and post-term pregnancy: a systematic review of literature with meta-analysis. (23561019)
2013
2
Female pseudohermaphroditism in a prenatally diagnosed cloacal malformation with hydronephrosis, dilated bladder, hydrometrocolpos, and oligohydramnios. (24411046)
2013
3
Pulmonary effects of prolonged oligohydramnios following mid-trimester rupture of the membranes--antenatal and postnatal management. (21934333)
2012
4
Influence of oligohydramnios on preterm premature rupture of the membranes at 30 to 36 weeks' gestation. (21176313)
2010
5
Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia. (19067285)
2009
6
Acute oligohydramnios: antenatal expression of VURD syndrome? (19816002)
2009
7
Congenital cytomegalovirus infection presenting with echogenic bowel and oligohydramnios. (17364293)
2007
8
Intravenous maternal hydration in third trimester oligohydramnios: effect on amniotic fluid volume. (17623581)
2007
9
Obstetricians' attitudes towards 'isolated' oligohydramnios at term. (17896253)
2007
10
Umbilical cord length in urinary tract abnormalities associated with oligohydramnios: evidence regarding developmental pathogenesis. (17438663)
2006
11
Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome presenting with a large nephrogenic cyst, severe oligohydramnios and hydrops fetalis: a case report and review of the literature. (15791665)
2005
12
Induction of labor in women with oligohydramnios. (16076620)
2005
13
Perinatal outcome associated with oligohydramnios in uncomplicated term pregnancies. (12928935)
2004
14
Premature rupture of the membranes at <26 weeks' gestation: role of amnioinfusion in the management of oligohydramnios. (15301294)
2004
15
Survival in second trimester oligohydramnios secondary to bilateral pelviureteral junction obstruction. (12736042)
2003
16
A review of amniotic fluid dynamics and the enigma of isolated oligohydramnios. (12152144)
2002
17
Maternal hydration for increasing amniotic fluid volume in oligohydramnios and normal amniotic fluid volume. (11869566)
2002
18
Evaluation of interleukin concentrations in amniotic fluid in preterm and term parturition and in oligohydramnios. (11535936)
2001
19
Oligohydramnios in healthy pregnancies: first do no harm. (12154722)
2001
20
Umbilical artery Doppler velocimetry in pregnancies complicated by oligohydramnios. (10948467)
2000
21
Overwhelming maternal cell contamination in amniotic fluid samples from patients with oligohydramnios can lead to false prenatal interphase FISH results. (10215080)
1999
22
Lipid peroxidation in cord blood: a randomised sequential pairs study of prophylactic saline amnioinfusion for intrapartum oligohydramnios. (9332992)
1997
23
Potential value of fetal echocardiography in the differential diagnosis of twin pregnancy with presence of polyhydramnios-oligohydramnios syndrome. (9290456)
1997
24
Accuracy of prenatal diagnosis of renal agenesis with color flow imaging in severe second-trimester oligohydramnios. (8610763)
1995
25
The effect of low amniotic pressure without oligohydramnios on fetal lung development in a rabbit model. (7631724)
1995
26
Is oligohydramnios a risk factor for infection in term premature rupture of membranes? (12797200)
1994
27
Oligohydramnios sequence: the spectrum of renal malformations. (8043538)
1994
28
Permanent resolution of severe second trimester oligohydramnios after transabdominal amnioinfusion. (8455384)
1993
29
Long bone development in extrinsic fetal akinesia: an experimental study in rat fetuses subjected to oligohydramnios. (1641814)
1992
30
Maternal serum alpha-fetoprotein levels and fetal outcome in early second-trimester oligohydramnios. (1377389)
1992
31
Fetal breathing movements are not a good indicator of lung development after premature rupture of membranes and oligohydramnios--a preliminary study. (1587225)
1992
32
Effects of acute oligohydramnios on respiratory system of fetal sheep. (1399988)
1992
33
Origin of raised maternal serum alpha-fetoprotein levels in second-trimester oligohydramnios. (1372972)
1992
34
The influence of experimentally produced oligohydramnios on lung growth and pulmonary surfactant content in fetal rabbits. (1812157)
1991
35
The influence of oligohydramnios on thoracic dimensions of fetal sheep. (1824117)
1991
36
Fetal breathing and pressures in the trachea and amniotic sac during oligohydramnios in sheep. (2010385)
1991
37
Transient oligohydramnios in a severely hypovolemic gravid woman at 35 weeks' gestation, with fluid reaccumulating immediately after intravenous maternal hydration. (2180306)
1990
38
Oligohydramnios sequence in a live-born infant following chorionic villus sampling. (2274492)
1990
39
The reliability and predictive value of an amniotic fluid scoring system in severe second-trimester oligohydramnios. (2649820)
1989
40
Visualization of fetal intra-abdominal organs in second-trimester severe oligohydramnios by intraperitoneal infusion. (2652131)
1989
41
Objective method of diagnosing oligohydramnios in postterm pregnancies. (3550131)
1987
42
Intrauterine cytomegalovirus infection associated with fetal ascites and oligohydramnios. (2829805)
1987
43
Ultrasound evaluation of amniotic fluid: outcome of pregnancies with severe oligohydramnios. (3515948)
1986
44
The sonographic evaluation of fetal anomalies in oligohydramnios between 16 and 30 weeks gestation. (3518372)
1986
45
Pregnancy outcome following ultrasound diagnosis of fetal urinary tract anomalies and/or oligohydramnios. (3331879)
1986
46
Effect of induced oligohydramnios on fetal lung development. (3963072)
1986
47
Ultrasound-detected oligohydramnios and fetal outcome. (6731530)
1984
48
Neurofibromatosis and pregnancy: report of a case complicated by intrauterine growth retardation and oligohydramnios. (6428234)
1984
49
Renal agenesis, oligohydramnios and diabetes mellitus. (4891577)
1969
50
Polyhydramnios and oligohydramnios. (13618797)
1959

Genetic Variations for Oligohydramnios

Expression for genes affiliated with Oligohydramnios

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oligohydramnios

Search GEO for disease gene expression data for Oligohydramnios.

Pathways for genes affiliated with Oligohydramnios

Sources:
12EMD Millipore, 54Reactome, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Oligohydramnios

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1gemeprost4510.4OXT, AFP
2diatrizoate4510.4NAGLU, AQP1
3pcmbs4510.4AQP3, AQP1
4hgcl24510.3AQP3, AQP1
5mercury4510.3AQP3, AQP1, NAGLU
6bibn 4096 bs4510.3GPR182, ADM
7galantamine45 50 1112.3CHRND, CHRNA1, CHRNG
8hg2+2910.2AQP1, AQP8, AQP3
9streptozotocin4510.2NAGLU, OXT, ADM
10forskolin45 50 1112.2AQP3, AQP8, ADM
11silver4510.2AQP1, AQP3, AFP
12urea45 11 2412.2AQP1, AQP3, NAGLU, AFP
13gentamicin45 1111.1NAGLU, OXT
14glycerol45 11 2412.0ADM, AQP1, AQP3, AQP8
15mannitol45 1110.9ADM, NAGLU, AQP1, OXT, AQP3
16potassium45 11 2411.8NAGLU, AQP1, ADM, AFP
17creatinine459.8OXT, AQP3, AQP1, AFP, NAGLU, ADM
18steroid459.7AQP1, ADM, NAGLU, OXT, AFP
19oligonucleotide459.7AQP3, AQP1, ADM, SERPINH1, AFP
20paraffin459.6AFP, ADM, AQP1, OXT
21glucose459.6AQP3, AFP, AQP1, ADM, TREH, NAGLU
22vegf459.2AFP, AQP1, SERPINH1, ADM, OXT

GO Terms for genes affiliated with Oligohydramnios

Sources:
16Gene Ontology
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Cellular components related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.0CHRND, CHRNA1, CHRNG

Biological processes related to Oligohydramnios according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.2CHRNA1, CHRND
2urea transportGO:01584010.1AQP3, AQP11
3neuromuscular processGO:05090510.1CHRND, CHRNA1
4glycerol transportGO:01579310.0AQP11, AQP1
5musculoskeletal movementGO:05088110.0CHRND, CHRNA1
6water transportGO:0068339.8AQP11, AQP1, AQP3, AQP8
7regulation of membrane potentialGO:0423919.7CHRNG, CHRNA1, CHRND
8transportGO:0068109.6AQP8, AFP, CHRNG, CHRNA1, CHRND, AQP3

Molecular functions related to Oligohydramnios according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.1CHRNA1, CHRNG
2water channel activityGO:0152509.9AQP1, AQP3, AQP8
3acetylcholine-activated cation-selective channel activityGO:0048899.9CHRND, CHRNG, CHRNA1
4acetylcholine bindingGO:0421669.8CHRND, CHRNA1

Products for genes affiliated with Oligohydramnios

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligohydramnios

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet