MCID: OLG001
MIFTS: 39

Oligospermia malady

Summaries for Oligospermia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and varicocele. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include testis, t cells and b cells.

Aliases & Classifications for Oligospermia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 22GTR, 45Novoseek, 40NCIt, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

oligospermia 8 10 61
oligozoospermia 8 22 45


External Ids:

Disease Ontology8 DOID:14228
NCIt40 C34860
MeSH35 D009845
ICD9CM27 606.1

Related Diseases for Oligospermia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Clinical Features for Oligospermia

Drugs & Therapeutics for Oligospermia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Oligospermia

Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Search CenterWatch for Oligospermia

Genetic Tests for Oligospermia

Sources:
22GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia22

Anatomical Context for Oligospermia

Sources:
33MalaCards
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MalaCards organs/tissues related to Oligospermia:

33
Testis, T cells, B cells, Pituitary, Testis leydig

Animal Models for Oligospermia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Oligospermia

Sources:
51PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
2
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. (21918533)
2012
3
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
4
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
5
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
6
A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia. (16968799)
2006
7
Novel method for the cryopreservation of testicular sperm and ejaculated spermatozoa from patients with severe oligospermia: a pilot study. (15302297)
2004
8
Effects of four methods of sperm preparation on motion characteristics and nitric oxide concentration in laboratory-prepared oligospermia. (11155759)
2000
9
Steroid 5alpha-reductase 2 gene melting polymorphisms in male subjects with azoospermia or oligospermia. (10368476)
1999
10
The first analysis of exon 1 (the transactivation domain) of the androgen receptor gene in infertile men with oligospermia or azoospermia. (7926115)
1994
11
Lipid metabolism in young males with hypotestosteronaemia and oligospermia prior to, during, and after treatment. (1938220)
1991
12
Over-expression of superoxide dismutase and lack of surface-thiols in spermatozoa: inherent defects in oligospermia. (1847045)
1991
13
Subfertile men with severe oligospermia: outcome of management. (3240756)
1988
14
Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. (3119647)
1987
15
The effects of mesterolone on sperm count in idiopathic oligospermia. (2887529)
1987
16
Assisted fertilization by zona drilling: a mouse model for correction of oligospermia. (3760806)
1986
17
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology. (6336098)
1984
18
Transurethral resection for ejaculatory duct stenosis and oligospermia. (6538147)
1984
19
Mechanism for delivery of sperm to fimbria in oligospermia. (7201413)
1982
20
Recovery from severe oligospermia after exposure to dibromochloropropane. (6780379)
1981
21
Psoriasis, methotrexate, and oligospermia. (7356357)
1980
22
Immunofluorescent studies on infertile males with oligospermia in the United Republic of Cameroon. (380221)
1979
23
Cortisone acetate versus clomiphene citrate in per-germinal idiopathic oligospermia. (439212)
1979
24
Prolactin and idiopathic oligospermia. (85895)
1979
25
Serum and seminal plasma prolactin levels in oligospermia. (30715)
1978
26
Search for transit difficulties in the epididymis for differential diagnosis of oligospermia]. (961325)
1976
27
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (1030546)
1976
28
Homologous artificial insemination and oligospermia. (1248659)
1976
29
The first pregnancies after treating of oligospermia by collected and stored human semen. (1143102)
1975
30
The treatment of oligospermia with various dosage regimes of gonadotropins. (6357)
1975
31
Pituitary gonadotropin response to luteinizing hormone-releasing hormone (LH-RH) in males with azo- and oligospermia. (4378)
1975
32
Estimation of number, mean size and size distribution of human spermatozoa in oligospermia using a Coulter counter. (4430992)
1974
33
A relationship between testicular biopsy score count and fertility of men treated for oligospermia. (4421730)
1974
34
Plasma testosterone and testosterone binding affinities in men with impotence, oligospermia, azoospermia, and hypogonadism. (4819173)
1974
35
Oligospermia and infertility in a man with varicocele and G chromosome translocation. (4813560)
1974
36
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973
37
Treatment of oligospermia by freezing and concentrating semen. (4362383)
1972
38
Idiopathic oligospermia: control observations and response to cisclomiphene. (5036593)
1972
39
Meiotic studies of the ejaculated seminal fluid of humans with normal sperm count and oligospermia. (4937211)
1971
40
Effect of arginine on oligospermia. (5435745)
1970
41
Treatment of normogonadotropic oligospermia with large doses of chorionic gonadotropin. (5726257)
1968
42
Ligature of left spermatic vein in the treatment of oligospermia. (5660247)
1968
43
The effect of human postmenopausal gonadotropins on infertile men with severe oligospermia. (6073929)
1967
44
Effects of human chorionic gonadotropin and human menopausal gonadotropin (pergonal) in males with oligospermia. (6020073)
1967
45
Analysis of ultimate fertility in 100 untreated cases of oligospermia and sterility. (13704845)
1960
46
Effect of oligospermia in insemination and fecundation in fertile women. (13846943)
1960
47
Oligospermia; a clinical study of treatment with methylandrostenediol. (13375713)
1956
48
Oligospermia and pregnancy; a study of 34 cases. (13152582)
1954
49
Influence of small doses of stilbestrol on oligospermia. (12991390)
1952
50
Vitamin A therapy in oligospermia. (14945537)
1952

Genetic Variations for Oligospermia

Expression for genes affiliated with Oligospermia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for genes affiliated with Oligospermia

Compounds for genes affiliated with Oligospermia

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dutasteride45 1111.2SRD5A2, AR
2leuprolide45 60 29 1113.1AR, GNRHR
3nandrolone decanoate45 1111.1AR, TF
4finasteride45 60 11 2412.9SRD5A2, AR
5dihydrotestosterone45 29 11 2412.8SRD5A2, CHKB, AR, GNRHR
6levodopa45 1110.7CHKB, AR, TF
7valine459.7GSTT1, AR, CSNK2A2, SRD5A2
8adenine45 11 2411.7TF, SRD5A2, AR
9ascorbic acid45 2410.5TF, AR, GSTT1, CHKB
10estradiol45 11 2411.5AR, GNRHR, CSNK2A2, CHKB, SRD5A2
11tamoxifen45 50 29 1112.5CSNK2A2, GNRHR, TF, AR, CHKB
12vitamin d459.5CSNK2A2, SRD5A2, CHKB, AR
13cocaine45 1110.4AR, CHKB, TF
14steroid459.2GSTT1, GNRHR, CSNK2A2, AR, CHKB, SRD5A2
15testosterone45 60 11 2412.2AR, DAZ4, GNRHR, DAZ1, SRD5A2, CHKB
16arginine459.2CHKB, SRD5A2, GSTT1, AR, GNRHR, CSNK2A2
17estrogen459.0CSNK2A2, GSTT1, SRD5A2, CHKB, AR, TF

GO Terms for genes affiliated with Oligospermia

Sources:
16Gene Ontology
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Cellular components related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.8DAZ2, HSFX1, MOCS2, PHF7, AR, USP9Y

Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male genitalia morphogenesisGO:0488089.9AR, KLHL10
2male gonad developmentGO:0085849.8AR, SRD5A2, KLHL10
3spermatogenesisGO:0072839.1AR, USP9Y, DAZ4, DAZ1, DAZ2, TSSK4
4cell differentiationGO:0301549.0TSSK4, SRD5A2, DAZ2, DAZ1, DAZ4
5multicellular organismal developmentGO:0072758.9TSSK6, GNRHR, DAZ4, DAZ1, DAZ2, TSSK4

Molecular functions related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:0001669.1DAZ2, DAZ1, DAZ4, RBMY1A1, MOCS2

Products for genes affiliated with Oligospermia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligospermia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet