MCID: OLG001
MIFTS: 43

Oligospermia malady

Reproductive diseases category
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Summaries for Oligospermia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and varicocele. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and finasteride have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Oligospermia

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8Disease Ontology, 10DISEASES, 62UMLS, 22GTR, 45Novoseek, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

oligospermia 8 10 62
oligozoospermia 8 22 45


External Ids:

Disease Ontology8 DOID:14228
NCIt40 C34860
MeSH35 D009845
ICD9CM27 606.1

Related Diseases for Oligospermia

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17GeneCards, 18GeneDecks
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Diseases related to Oligospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia30.7AZF1, DAZ2, DAZ4, DAZ1, CFTR, TSSK6
2varicocele30.6AZF1, PRL
3infertility30.5AR, GSTT1, PRL, GNRHR, CFTR, AZF1
4y chromosome infertility30.4DAZ1
5sertoli cell-only syndrome30.3DAZ1, DAZ2
6male infertility30.2AR, PRL, CFTR
7cryptorchidism30.0AR, AZF1, DAZ1
8gynecomastia29.9AR, SRD5A2, PRL
9hypogonadism29.8TF, GNRHR, PRL, AR
10cervicitis10.2
11bronchiectasis oligospermia10.2
12bronchiectasis10.1
13impotence10.1
14psoriasis10.1
15blindness10.1
16smith magenis syndrome10.1DAZ1, AZF1
17penis agenesis10.0AR, SRD5A2
18androgenic alopecia10.0SRD5A2, AR
19androgen insensitivity syndrome10.0AR, SRD5A2
20pseudohermaphroditism10.0AR, SRD5A2
21nutritional deficiency disease10.0CFTR, TF
22hypospadias10.0AR, SRD5A2
23galactosemia10.0CHKB, TF
24neuromuscular disease10.0GNRHR, CHKB, AR
25precocious puberty10.0PRL, GNRHR
26cystic fibrosis10.0
27hyperprolactinemia10.0
28kallmann syndrome10.0
29obesity10.0
30spinocerebellar ataxia10.0
31testicular disease10.0
32ataxia10.0
33spermatogenic failure 1310.0
34hemochromatosis10.0TF, CFTR
35polycystic ovary syndrome10.0AR, PRL
36motor neuron disease10.0AR, GSTT1
37prostate cancer10.0GNRHR, SRD5A2, GSTT1, AR
38hyperandrogenism10.0AR, PRL
39williams-beuren syndrome10.0
40oculocerebrorenal syndrome10.0
41hyperglycemia10.0
42schizophrenia10.0
43testicular cancer10.0
4448,xxxy syndrome10.0
4548,xxyy syndrome10.0
4649,xxxxy syndrome10.0
47deafness-infertility syndrome10.0
48hypereosinophilic syndrome10.0
49ring chromosome 1210.0
50precocious puberty, male10.0

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Symptoms for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Genetic Tests for Oligospermia

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22GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia22

Anatomical Context for Oligospermia

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33MalaCards
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MalaCards organs/tissues related to Oligospermia:

33
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Oligospermia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8CFTR, GNRHR, CHKB, PRL, GSTT1, AR
2MP:00053797.5PYGO2, CFTR, GNRHR, PRL, SRD5A2, KLHL10
3MP:00053896.9AR, PYGO2, CFTR, GNRHR, TSSK6, PRL

Publications for Oligospermia

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52PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. (24369145)
2014
2
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. (23885232)
2013
3
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. (24034937)
2013
4
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. (24083421)
2013
5
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
6
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. (21918533)
2012
7
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
8
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
9
Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (20218307)
2009
10
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
11
Ring chromosome 12 and severe oligospermia: a case report. (17880954)
2008
12
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. (18555230)
2008
13
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? (17982752)
2008
14
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). (17218411)
2007
15
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. (16864151)
2006
16
Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. (16313071)
2005
17
Rapamycin-induced oligospermia. (14501876)
2003
18
Testicular fine needle aspiration cytology for the diagnosis of azoospermia and oligospermia. (10833990)
2000
19
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
20
Biochemical parameters in evaluation of oligospermia. (8089906)
1994
21
Intrauterine insemination as a successful method in the treatment of infertility caused by oligospermia. (7985455)
1993
22
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
23
Episodic luteinizing hormone release in idiopathic oligospermia. (1981212)
1990
24
Immunological studies in patients with oligospermia. (2806606)
1989
25
Cluster of oligospermia among four men occupationally exposed to methylene chloride (MeCl) (2520532)
1989
26
Possibilities of association of azoospermia and oligospermia with some HLA system antigens. (3162459)
1988
27
Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. (3119647)
1987
28
Demonstrated paternity in spite of severe idiopathic oligospermia. (3469106)
1987
29
Tamoxifen and oligospermia. (3938205)
1985
30
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology. (6336098)
1984
31
Differential effect of luteinizing hormone-releasing hormone infusion on testicular steroids in normal men and patients with idiopathic oligospermia. (6430726)
1984
32
Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen. (6404663)
1983
33
Mechanism for delivery of sperm to fimbria in oligospermia. (7201413)
1982
34
The levels of the male serum and seminal fluid prolactin in oligospermia and azoospermia. (6114065)
1981
35
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
36
Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate. (7364070)
1980
37
Effect of synthetic LH-RH and hCG administration on plasma testosterone, androstenedione, and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia. (37185)
1979
38
Oligospermia secondary to mA1llerian duct cyst. Simple surgical cure. (664145)
1978
39
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (916056)
1977
40
Search for transit difficulties in the epididymis for differential diagnosis of oligospermia]. (961325)
1976
41
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (1030546)
1976
42
The first pregnancies after treating of oligospermia by collected and stored human semen. (1143102)
1975
43
Estimation of number, mean size and size distribution of human spermatozoa in oligospermia using a Coulter counter. (4430992)
1974
44
Human menopausal gonadotropins in the treatment of patients with oligospermia. (4422230)
1974
45
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973
46
Treatment of oligospermia with urinary human menopausal gonadotrophin: a preliminary report. (5921777)
1966
47
TREATMENT OF OLIGOSPERMIA WITH LARGE DOSES OF HUMAN CHORIONIC GONADOTROPIN. (14057786)
1963
48
Oligospermia and pregnancy; a study of 34 cases. (13152582)
1954
49
Influence of small doses of stilbestrol on oligospermia. (12991390)
1952
50
Influence of arginine on oligospermia. (20250427)
1947

Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 51PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1dutasteride45 1111.2AR, SRD5A2
2finasteride45 61 24 1113.0AR, SRD5A2
3leuprolide acetate4510.0GNRHR, PRL
4buserelin45 29 1112.0GNRHR, PRL
5streptomycin51 45 1112.0TF, GSTT1
6nandrolone decanoate45 1110.9TF, AR
7silver nitrate459.9TF, CFTR
8rsai459.8GSTT1, SRD5A2
9leuprolide45 61 29 1112.8GNRHR, PRL, AR
10Hydrogen carbonate249.8CFTR, TF
11fe3+459.8TF, CHKB
12mgatp459.8CHKB, CFTR
13danazol45 24 1111.8AR, PRL, GNRHR
14gentamicin45 1110.7CFTR, TF
15triamcinolone acetonide45 2910.7CFTR, TF
16cyproteroneacetate459.7PRL, AR
17androstenedione45 2410.7PRL, SRD5A2, AR
18bicarbonate459.7TF, CFTR, CHKB
19polyethylene glycol459.6PRL, CHKB, TF
20citrate459.6TF, CFTR, CHKB
21adenine45 24 1111.6AR, SRD5A2, TF
22levonorgestrel45 61 29 1112.5PRL, AR
23vitamin d459.5CFTR, CHKB, SRD5A2, AR
24thyroxine45 2410.5TF, CHKB, PRL
25valine459.4CFTR, SRD5A2, GSTT1, AR
26doxorubicin45 51 1111.4CFTR, GNRHR, GSTT1, AR
27gnrh459.3AR, PRL, GNRHR, CFTR
28adenylate459.3CFTR, GNRHR, CHKB, AR
29n acetylcysteine459.3TF, CFTR, CHKB, AR
30levodopa45 1110.3AR, PRL, CHKB, TF
31cocaine45 1110.3AR, PRL, CHKB, TF
32paraffin459.2TF, CFTR, CHKB, AR
33pge2459.2AR, CHKB, CFTR, TF
34norepinephrine45 24 1111.2PRL, CHKB, CFTR, TF
35dihydrotestosterone45 29 24 1112.2GNRHR, CHKB, PRL, SRD5A2, AR
36progesterone45 29 61 24 1113.2GNRHR, PRL, SRD5A2, AR
37aspartate459.2TF, CFTR, CHKB, AR
38estradiol45 24 1111.2GNRHR, CHKB, PRL, SRD5A2, AR
39agar459.0AR, CHKB, TF
40glutamine459.0TF, CFTR, CHKB, SRD5A2, AR
41ascorbic acid45 2410.0TF, CFTR, CHKB, GSTT1, AR
42alanine459.0TF, CFTR, GNRHR, CHKB, SRD5A2
43tamoxifen45 51 29 1112.0TF, GNRHR, CHKB, PRL, AR
44glutamate458.9TF, CFTR, GNRHR, CHKB, AR
45dopamine45 29 24 1111.9PRL, CHKB, GNRHR, CFTR, TF
46epinephrine45 24 1110.9AR, PRL, CHKB, CFTR, TF
47steroid458.8GNRHR, CHKB, PRL, SRD5A2, GSTT1, AR
48arginine458.8GNRHR, CHKB, PRL, SRD5A2, GSTT1, AR
49estrogen457.9TF, CFTR, GNRHR, CHKB, PRL, SRD5A2
50testosterone45 61 24 1110.9AR, DAZ1, DAZ4, CFTR, GNRHR, CHKB

GO Terms for genes affiliated with Oligospermia

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16Gene Ontology
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Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell differentiationGO:0301549.0SRD5A2, DAZ2, DAZ4, DAZ1
2multicellular organismal developmentGO:0072757.9TSSK6, GNRHR, DAZ2, DAZ4, DAZ1

Products for genes affiliated with Oligospermia

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Sources for Oligospermia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet