MCID: OLG001
MIFTS: 36

Oligospermia malady

Categories: Reproductive diseases

Aliases & Classifications for Oligospermia

Aliases & Descriptions for Oligospermia:

Name: Oligospermia 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD10 33 N46.1 N46.11
ICD9CM 35 606.1
MeSH 42 D009845
NCIt 47 C34860
UMLS 69 C0028960

Summaries for Oligospermia

MalaCards based summary : Oligospermia is related to bronchiectasis oligospermia and y chromosome infertility. An important gene associated with Oligospermia is DAZ4 (Deleted In Azoospermia 4), and among its related pathways/superpathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Naphthalene metabolism. The drugs Metformin and Enclomiphene have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 71 Terms oligospermia and oligozoospermia refer to semen with a low concentration of sperm and is a common... more...

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 bronchiectasis oligospermia 11.8
2 y chromosome infertility 11.6
3 androgen insensitivity, partial, with or without breast cancer 10.8
4 spermatogenic failure, y-linked, 2 10.8
5 azoospermia 10.4
6 infertility 10.3
7 glioblastoma mesenchymal subtype 10.2 AR PRL
8 sphingolipidosis 10.2 AR PRL
9 mature teratoma 10.1 AR KITLG
10 differentiated thyroid carcinoma 10.1 GSTM1 GSTT1
11 emery-dreifuss muscular dystrophy, x-linked 10.1 GSTM1 GSTT1
12 lichen planus pigmentosus 10.1 GSTM1 GSTT1
13 varicocele 10.1
14 exocervical carcinoma 10.1 AR PRL
15 villous adenoma 10.1 GSTM1 GSTT1
16 cervical adenomyoma 10.1 CFTR GSTM1
17 retinitis pigmentosa, y-linked 10.0 DAZ1 DAZ4
18 tenosynovitis 10.0 GSTM1 GSTT1
19 microglandular adenosis of breast 10.0 GSTM1 KITLG
20 19p13.12 microdeletion syndrome 10.0 DAZ1 PRL
21 pauciarticular onset juvenile idiopathic arthritis 10.0 DAZ1 DAZ4
22 rapsn-related fetal akinesia deformation sequence 10.0 AR GSTM1 GSTT1
23 byssinosis 10.0 GSTM1 GSTT1
24 mycobacterium kansasii 10.0 GSTM1 GSTT1
25 retroperitoneal sarcoma 10.0 GSTM1 GSTT1 PRL
26 male infertility 10.0
27 immune system disease 10.0 GNRHR GSTM1 GSTT1
28 diabetes mellitus, insulin-resistant, with acanthosis nigricans 9.9 AR DAZ1 DAZ4
29 gaucher's disease 9.9 AR DAZ4 GNRHR PRL
30 cervicitis 9.9
31 esophageal neuroendocrine tumor 9.9 GSTM1 GSTT1
32 hyperparathyroidism, neonatal 9.9 GSTM1 GSTT1 KITLG
33 impotence 9.8
34 psoriasis 9.8
35 bronchiectasis 9.8
36 adenosquamous cell lung carcinoma 9.8 AR CFTR DAZ1 DAZ4
37 orbital cyst 9.8 AR CFTR DAZ1 DAZ4
38 mantle cell lymphoma 9.8 AR CFTR DAZ1 DAZ4
39 pustular psoriasis 9.7
40 ring chromosome 12 9.7
41 gynecomastia 9.7
42 hypogonadism 9.7
43 testicular cancer 9.7
44 hyperglycemia 9.7
45 schizophrenia 9.7
46 hypereosinophilic syndrome 9.7
47 cryptorchidism 9.7
48 transmitted_by 9.7
49 avoidant personality disorder 9.7 AR CFTR DAZ1 DAZ4 PRL
50 benign perivascular tumor 9.6 AR CFTR DAZ1 DAZ4 PRL

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 AR CFTR GNRHR KITLG KLHL10 PRL
2 reproductive system MP:0005389 9.17 AR CFTR GNRHR KITLG KLHL10 PRL

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Enclomiphene Investigational Phase 4 15690-57-0
3 insulin Phase 4
4 Hypoglycemic Agents Phase 4
5 Estrogens Phase 4,Phase 3
6 Insulin, Globin Zinc Phase 4
7 Clomiphene Phase 4
8 Chelating Agents Phase 4
9 Selective Estrogen Receptor Modulators Phase 4
10 Chorionic Gonadotropin Phase 4
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Estrogen Antagonists Phase 4,Phase 3
15 Estrogen Receptor Modulators Phase 4
16 Zuclomiphene Phase 4
17 Fertility Agents Phase 4
18 Anticoagulants Phase 4
19 Calcium, Dietary Phase 4,Phase 2
20 Citrate Nutraceutical Phase 4
21
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
22
Testosterone Approved, Investigational Phase 3 58-22-0 6013
23
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
24
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
25
Menthol Approved Phase 3 2216-51-5 16666
26
Methyltestosterone Approved Phase 3 58-18-4 6010
27
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
28
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 54575, 6560146 143
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
30 Trace Elements Phase 2, Phase 3
31 Vitamins Phase 2, Phase 3
32 Micronutrients Phase 2, Phase 3
33 Hematinics Phase 2, Phase 3
34 Vitamin B Complex Phase 2, Phase 3
35 Testosterone undecanoate Phase 3
36 Estradiol valerate Phase 3 979-32-8
37 Steroid Synthesis Inhibitors Phase 3
38 Testosterone 17 beta-cypionate Phase 3
39
Testosterone enanthate Phase 3 315-37-7 9416
40 Anabolic Agents Phase 3
41 Androgens Phase 3
42 Estradiol 17 beta-cypionate Phase 3
43 Estradiol 3-benzoate Phase 3
44 Polyestradiol phosphate Phase 3
45 Aromatase Inhibitors Phase 3
46 Antineoplastic Agents, Hormonal Phase 3
47 Folate Nutraceutical Phase 2, Phase 3
48 Inositol Nutraceutical Phase 2, Phase 3
49 Sweet Basil Nutraceutical Phase 3
50 Ginger Nutraceutical Phase 3

Interventional clinical trials:

(show all 31)
id Name Status NCT ID Phase
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4
2 Metformin for the Treatment of Unexplained Oligozspermia Recruiting NCT01529177 Phase 4
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Not yet recruiting NCT02719093 Phase 4
4 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
5 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
6 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
7 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Recruiting NCT02900105 Phase 3
8 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Recruiting NCT02605070 Phase 3
9 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Recruiting NCT02998593 Phase 3
10 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
11 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3
12 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2
13 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2
14 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2
15 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
16 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584
17 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799
18 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482
19 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
20 Genetic Studies Spermatogenic Failure Completed NCT00548977
21 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295
22 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
23 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
24 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
25 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
26 Fertility Preservation in Cases of Klinefelter Syndrome. Recruiting NCT01918280
27 Oxidative Stress and Lipidomics in Male Infertility Active, not recruiting NCT02062229
28 The Effect of Low Electrical Current on Testicular Spermatocyte Count Not yet recruiting NCT02617173
29 Preimplantation Genetic Screening in Patients With Male Factor Infertility Not yet recruiting NCT02941965
30 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Not yet recruiting NCT02932527
31 Ramipril for the Treatment of Oligospermia Terminated NCT01856361

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligospermia 29

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

39
Testis, Pituitary

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 181)
id Title Authors Year
1
A Role for Heterozygosity of NF-d998B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia. ( 27041523 )
2016
2
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia. ( 27812445 )
2016
3
Re: Higher Pregnancy Rates Using Testicular Sperm in Men with Severe Oligospermia. ( 27597099 )
2016
4
Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ( 26940145 )
2016
5
A novel nomogram for prediction of spermatogenic improvement following empiric medical therapy for moderate-severe oligospermia. ( 26892053 )
2016
6
Higher pregnancy rates using testicular sperm in men with severe oligospermia. ( 26363389 )
2015
7
Re: Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25986825 )
2015
8
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. ( 26345837 )
2015
9
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. ( 25106941 )
2014
10
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. ( 24369145 )
2014
11
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: aA randomized phase II clinical trial comparing topical testosterone. ( 25044085 )
2014
12
Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China. ( 25532576 )
2014
13
Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. ( 24756080 )
2014
14
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia. ( 25109708 )
2014
15
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. ( 24631383 )
2014
16
Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia. ( 25536748 )
2014
17
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. ( 24083421 )
2013
18
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. ( 23732668 )
2013
19
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. ( 23885232 )
2013
20
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. ( 24034937 )
2013
21
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. ( 24002933 )
2013
22
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. ( 23384712 )
2013
23
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 23141270 )
2012
24
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 22378155 )
2012
25
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. ( 21918533 )
2012
26
Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. ( 23162296 )
2012
27
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. ( 22905450 )
2012
28
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). ( 21382069 )
2011
29
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. ( 20078516 )
2010
30
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. ( 19338535 )
2009
31
[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. ( 20218307 )
2009
32
Azoospermia and severe oligospermia in testicular cancer. ( 19499754 )
2009
33
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 18399835 )
2008
34
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. ( 18097510 )
2008
35
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. ( 18555230 )
2008
36
Ring chromosome 12 and severe oligospermia: a case report. ( 17880954 )
2008
37
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. ( 19062477 )
2008
38
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? ( 17982752 )
2008
39
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 17941933 )
2008
40
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). ( 17218411 )
2007
41
[Genetic polymorphism of glutathione S-transferase T1 associated with idiopathic azoospermia and oligospermia]. ( 17569254 )
2007
42
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. ( 16864151 )
2006
43
A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia. ( 16968799 )
2006
44
Gynaecomastia with oligospermia: an unusual complication of low-dose methotrexate for pustular psoriasis. ( 16309512 )
2006
45
Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. ( 16313071 )
2005
46
Oral androstenedione-induced impotence and severe oligospermia. ( 16009183 )
2005
47
Novel method for the cryopreservation of testicular sperm and ejaculated spermatozoa from patients with severe oligospermia: a pilot study. ( 15302297 )
2004
48
Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. ( 15537917 )
2004
49
Live births after intracytoplasmic sperm injection in the management of oligospermia and azoospermia in Nigeria. ( 12816319 )
2003
50
Rapamycin-induced oligospermia. ( 14501876 )
2003

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.42 GSTM1 GSTT1
2 10 GSTM1 GSTT1

GO Terms for Oligospermia

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.37 GSTM1 GSTT1
2 male gonad development GO:0008584 9.33 AR KITLG KLHL10
3 fertilization GO:0009566 9.32 AR KLHL10
4 glutathione derivative biosynthetic process GO:1901687 9.26 GSTM1 GSTT1
5 spermatogenesis GO:0007283 9.02 AR DAZ1 DAZ4 KLHL10 TSSK4
6 male genitalia morphogenesis GO:0048808 8.96 AR KLHL10

Molecular functions related to Oligospermia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.62 GSTM1 GSTT1

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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