MCID: OLG001
MIFTS: 38

Oligospermia malady

Summaries for Oligospermia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and infertility. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary.

Aliases & Classifications for Oligospermia

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8Disease Ontology, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

oligospermia 8 10 60
oligozoospermia 8 22 44


External Ids:

Disease Ontology8 DOID:14228
NCIt39 C34860
MeSH34 D009845
ICD9CM27 606.1

Related Diseases for Oligospermia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Clinical Features for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oligospermia

Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Search CenterWatch for Oligospermia

Genetic Tests for Oligospermia

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22GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia22

Anatomical Context for Oligospermia

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32MalaCards
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MalaCards organs/tissues related to Oligospermia:

32
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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Publications for Oligospermia

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50PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. (24083421)
2013
2
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. (24002933)
2013
3
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. (23384712)
2013
4
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (22378155)
2012
5
Ring chromosome 12 and severe oligospermia: a case report. (17880954)
2008
6
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? (17982752)
2008
7
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (18399835)
2008
8
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. (19062477)
2008
9
Genetic polymorphism of glutathione S-transferase T1 associated with idiopathic azoospermia and oligospermia]. (17569254)
2007
10
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. (16864151)
2006
11
Gynaecomastia with oligospermia: an unusual complication of low-dose methotrexate for pustular psoriasis. (16309512)
2006
12
Oral androstenedione-induced impotence and severe oligospermia. (16009183)
2005
13
Rapamycin-induced oligospermia. (14501876)
2003
14
Live births after intracytoplasmic sperm injection in the management of oligospermia and azoospermia in Nigeria. (12816319)
2003
15
Mutations and polymorphisms in CFTR genes in infertile men with oligospermia or azoospermia]. (12073281)
2002
16
Azoospermia and oligospermia among a large cohort of DBCP applicators in 12 countries. (10330512)
1999
17
Role of low-dose estrogen-testosterone combination therapy in men with oligospermia. (9797116)
1998
18
Intracytoplasmic sperm injection: a treatment for extreme oligospermia. (8709295)
1996
19
Oligospermia and its relation with hormonal profile. (8683833)
1995
20
Biochemical parameters in evaluation of oligospermia. (8089906)
1994
21
Intrauterine insemination as a successful method in the treatment of infertility caused by oligospermia. (7985455)
1993
22
Oligospermia associated with normal testicular function and epididymal lesions or malpositions. (1342538)
1992
23
Artificial insemination for oligospermia. A critical review. (1746215)
1991
24
Episodic luteinizing hormone release in idiopathic oligospermia. (1981212)
1990
25
Sperm washing and intrauterine insemination for cervical factor, oligospermia, immunologic infertility and unexplained infertility. (2406436)
1990
26
Altered pulsatile pattern of luteinizing hormone in men with idiopathic normogonadotropic oligospermia. (3135207)
1988
27
Idiopathic oligospermia and peripheral androgen metabolism. (3743799)
1986
28
Clomiphene citrate does not improve spermatozoal fertilizing capacity in idiopathic oligospermia. (4007185)
1985
29
Androgen receptor abnormalities in identical twins with oligospermia. Clinical and biochemical studies. (6439037)
1984
30
Studies of the human testis. XVI. Evaluation of multiple indexes of testicular function in relation to advanced age, idiopathic oligospermia, or varicocele. (7141012)
1982
31
The levels of the male serum and seminal fluid prolactin in oligospermia and azoospermia. (6114065)
1981
32
Testicular tumour associated with hormonal treatment for oligospermia. (6116891)
1981
33
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
34
Immunoglobulins in the semen of men with azoospermia, oligospermia, or self-agglutination of spermatozoa. (7439412)
1980
35
Effect of synthetic LH-RH and hCG administration on plasma testosterone, androstenedione, and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia. (37185)
1979
36
Effects of long-term treatment with metergoline in patients with idiopathic oligospermia. (509746)
1979
37
Seminal fluid prolactin: studies in normal subjects and in hypergonadotropic oligospermia. (456635)
1979
38
Oligospermia secondary to mA1llerian duct cyst. Simple surgical cure. (664145)
1978
39
Effect of clomiphene citrate on plasma levels of immunoreactive luteinizing hormone-releasing hormone, gonadotropin, and testosterone in normal subjects and in patients with idiopathic oligospermia. (348501)
1978
40
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (916056)
1977
41
Lactate and malate dehydrogenase and alpha-esterases in oligospermia. (950051)
1976
42
Ciscomiphene citrate in the management of oligospermia. (5033995)
1972
43
Relationship between spermatogenesis and serum gonadotropin levels in azoospermia and oligospermia. (5020414)
1972
44
Testicular biopsy in marked oligospermia. A survey of 275 cases. (5162723)
1971
45
Monotropic increase of serum FSH correlated with low sperm count in young men with idiopathic oligospermia and aspermia. (5099999)
1971
46
TREATMENT OF OLIGOSPERMIA WITH LARGE DOSES OF HUMAN CHORIONIC GONADOTROPIN. (14057786)
1963
47
The treatment of oligospermia with stilbestrol and vitamin B. (13707021)
1961
48
Oligospermia associated with impaired dark adaptation. (18107709)
1948
49
Constant oligospermia and periodic oligospermia. (18894812)
1948
50
Influence of arginine on oligospermia. (20250427)
1947

Genetic Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

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Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dutasteride44 1111.2AR, SRD5A2
2leuprolide44 59 28 1113.1GNRHR, AR
3nandrolone decanoate44 1111.1AR, TF
4finasteride44 59 11 2412.9AR, SRD5A2
5dihydrotestosterone44 28 11 2412.8GNRHR, AR, CHKB, SRD5A2
6levodopa44 1110.7CHKB, AR, TF
7valine449.7CSNK2A2, AR, SRD5A2, GSTT1
8adenine44 11 2411.7SRD5A2, AR, TF
9ascorbic acid44 2410.5GSTT1, CHKB, AR, TF
10estradiol44 11 2411.5GNRHR, CSNK2A2, AR, CHKB, SRD5A2
11tamoxifen44 49 28 1112.5CHKB, AR, TF, CSNK2A2, GNRHR
12vitamin d449.5SRD5A2, CHKB, AR, CSNK2A2
13cocaine44 1110.4CHKB, AR, TF
14steroid449.2GNRHR, CSNK2A2, AR, CHKB, SRD5A2, GSTT1
15testosterone44 59 11 2412.2GNRHR, AR, CHKB, DAZ4, DAZ1, SRD5A2
16arginine449.2GSTT1, SRD5A2, CHKB, AR, CSNK2A2, GNRHR
17estrogen449.0GNRHR, CSNK2A2, TF, AR, CHKB, SRD5A2

GO Terms for genes affiliated with Oligospermia

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16Gene Ontology
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Cellular components related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.8DAZ2, HSFX1, MOCS2, PHF7, AR, USP9Y

Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male genitalia morphogenesisGO:0488089.9AR, KLHL10
2male gonad developmentGO:0085849.8SRD5A2, AR, KLHL10
3spermatogenesisGO:0072839.1TSSK4, DAZ2, DAZ1, DAZ4, USP9Y, AR
4cell differentiationGO:0301549.0DAZ4, DAZ1, DAZ2, SRD5A2, TSSK4
5multicellular organismal developmentGO:0072758.9GNRHR, DAZ4, DAZ1, DAZ2, TSSK4, TSSK6

Molecular functions related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:0001669.1DAZ2, DAZ1, DAZ4, RBMY1A1, MOCS2

Products for genes affiliated with Oligospermia

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  • Antibodies
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  • Antibodies

Sources for Oligospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet