MCID: OLG001
MIFTS: 42

Oligospermia malady

Reproductive diseases category

Summaries for Oligospermia

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Wikipedia:64 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards based summary: Oligospermia, also known as oligozoospermia, is related to y chromosome infertility and sertoli cell-only syndrome. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and finasteride have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Oligospermia

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 23GTR, 44Novoseek, 34MeSH, 28ICD9CM, 39NCIt
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Oligospermia, Aliases & Descriptions:

Name: Oligospermia 9 11 61
 
Oligozoospermia 9 23 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:14228
MeSH34 D009845
ICD9CM28 606.1
NCIt39 C34860

Related Diseases for Oligospermia

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Diseases related to Oligospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1y chromosome infertility31.0DAZ1
2sertoli cell-only syndrome30.8DAZ2, DAZ1
3varicocele30.8PRL, AZF1
4cryptorchidism30.2AZF1, AR, DAZ1
5male infertility30.1AR, CFTR, PRL
6azoospermia29.9CFTR, PRL, TSSK6, AZF1, DAZ2, DAZ4
7gynecomastia29.7SRD5A2, PRL, AR
8hypogonadism29.4AR, PRL, GNRHR, TF
9infertility29.4DAZ1, DAZ4, DAZ2, AZF1, CFTR, GNRHR
10smith magenis syndrome10.3DAZ1, AZF1
11bronchiectasis oligospermia10.3
12cervicitis10.2
13penis agenesis10.2AR, SRD5A2
14androgenetic alopecia10.2SRD5A2, AR
15androgen insensitivity syndrome10.2SRD5A2, AR
16pseudohermaphroditism10.2SRD5A2, AR
17bronchiectasis10.1
18impotence10.1
19psoriasis10.1
20blindness10.1
21nutritional deficiency disease10.1TF, CFTR
22hypospadias10.1SRD5A2, AR
23galactosemia10.1TF, CHKB
24neuromuscular disease10.1GNRHR, CHKB, AR
25precocious puberty10.0PRL, GNRHR
26cystic fibrosis10.0
27obesity10.0
28hyperprolactinemia10.0
29kallmann syndrome10.0
30spinocerebellar ataxia10.0
31testicular disease10.0
32spermatogenic failure 810.0
33ataxia10.0
34schizophrenia10.0
35williams-beuren syndrome10.0
36oculocerebrorenal syndrome10.0
37hyperglycemia10.0
38testicular cancer10.0
3948,xxxy syndrome10.0
4048,xxyy syndrome10.0
4149,xxxxy syndrome10.0
42deafness-infertility syndrome10.0
43hypereosinophilic syndrome10.0
44ring chromosome 1210.0
45precocious puberty, male10.0
46fanconi anemia, complementation group j10.0
47epididymitis10.0
488p11.2 deletion syndrome10.0
49hemochromatosis10.0CFTR, TF
50motor neuron disease9.9AR, GSTT1

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Symptoms for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Genetic Tests for Oligospermia

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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia23

Anatomical Context for Oligospermia

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MalaCards organs/tissues related to Oligospermia:

32
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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MGI Mouse Phenotypes related to Oligospermia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8CFTR, GNRHR, CHKB, PRL, GSTT1, AR
2MP:00053797.5PYGO2, CFTR, GNRHR, PRL, SRD5A2, KLHL10
3MP:00053896.9AR, PYGO2, CFTR, GNRHR, TSSK6, PRL

Publications for Oligospermia

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Articles related to Oligospermia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. (24369145)
2014
2
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. (24631383)
2014
3
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. (23885232)
2013
4
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. (24034937)
2013
5
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. (24083421)
2013
6
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
7
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. (21918533)
2012
8
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
9
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
10
Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (20218307)
2009
11
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
12
Ring chromosome 12 and severe oligospermia: a case report. (17880954)
2008
13
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. (18555230)
2008
14
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? (17982752)
2008
15
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). (17218411)
2007
16
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. (16864151)
2006
17
Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. (16313071)
2005
18
Rapamycin-induced oligospermia. (14501876)
2003
19
Testicular fine needle aspiration cytology for the diagnosis of azoospermia and oligospermia. (10833990)
2000
20
Effects of four methods of sperm preparation on motion characteristics and nitric oxide concentration in laboratory-prepared oligospermia. (11155759)
2000
21
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
22
Biochemical parameters in evaluation of oligospermia. (8089906)
1994
23
Intrauterine insemination as a successful method in the treatment of infertility caused by oligospermia. (7985455)
1993
24
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
25
Immunological studies in patients with oligospermia. (2806606)
1989
26
Possibilities of association of azoospermia and oligospermia with some HLA system antigens. (3162459)
1988
27
Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. (3119647)
1987
28
Demonstrated paternity in spite of severe idiopathic oligospermia. (3469106)
1987
29
Tamoxifen and oligospermia. (3938205)
1985
30
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology. (6336098)
1984
31
Differential effect of luteinizing hormone-releasing hormone infusion on testicular steroids in normal men and patients with idiopathic oligospermia. (6430726)
1984
32
Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen. (6404663)
1983
33
Mechanism for delivery of sperm to fimbria in oligospermia. (7201413)
1982
34
The levels of the male serum and seminal fluid prolactin in oligospermia and azoospermia. (6114065)
1981
35
Recovery from severe oligospermia after exposure to dibromochloropropane. (6780379)
1981
36
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
37
Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate. (7364070)
1980
38
Effect of synthetic LH-RH and hCG administration on plasma testosterone, androstenedione, and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia. (37185)
1979
39
Oligospermia secondary to mA1llerian duct cyst. Simple surgical cure. (664145)
1978
40
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (916056)
1977
41
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (1030546)
1976
42
The first pregnancies after treating of oligospermia by collected and stored human semen. (1143102)
1975
43
Estimation of number, mean size and size distribution of human spermatozoa in oligospermia using a Coulter counter. (4430992)
1974
44
Human menopausal gonadotropins in the treatment of patients with oligospermia. (4422230)
1974
45
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973
46
Treatment of oligospermia with urinary human menopausal gonadotrophin: a preliminary report. (5921777)
1966
47
TREATMENT OF OLIGOSPERMIA WITH LARGE DOSES OF HUMAN CHORIONIC GONADOTROPIN. (14057786)
1963
48
Oligospermia and pregnancy; a study of 34 cases. (13152582)
1954
49
Influence of small doses of stilbestrol on oligospermia. (12991390)
1952
50
Influence of arginine on oligospermia. (20250427)
1947

Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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Expression patterns in normal tissues for genes affiliated with Oligospermia

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Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1dutasteride44 1211.2SRD5A2, AR
2finasteride44 60 25 1213.0AR, SRD5A2
3leuprolide acetate4410.0PRL, GNRHR
4buserelin44 29 1212.0PRL, GNRHR
5streptomycin50 44 1212.0GSTT1, TF
6nandrolone decanoate44 1210.9TF, AR
7silver nitrate449.9CFTR, TF
8rsai449.8SRD5A2, GSTT1
9leuprolide44 60 29 1212.8GNRHR, PRL, AR
10Hydrogen carbonate259.8TF, CFTR
11mgatp449.8CHKB, CFTR
12danazol44 25 1211.8AR, GNRHR, PRL
13cyproteroneacetate449.8AR, PRL
14triamcinolone acetonide44 2910.7TF, CFTR
15fe3+449.7TF, CHKB
16gentamicin44 1210.7TF, CFTR
17androstenedione44 2510.7SRD5A2, AR, PRL
18bicarbonate449.7CHKB, CFTR, TF
19polyethylene glycol449.6PRL, CHKB, TF
20citrate449.6TF, CHKB, CFTR
21adenine44 25 1211.6TF, SRD5A2, AR
22levonorgestrel44 60 29 1212.5PRL, AR
23vitamin d449.5AR, SRD5A2, CHKB, CFTR
24thyroxine44 2510.5TF, CHKB, PRL
25valine449.4AR, GSTT1, SRD5A2, CFTR
26doxorubicin44 50 1211.4AR, CFTR, GNRHR, GSTT1
27gnrh449.3PRL, GNRHR, CFTR, AR
28adenylate449.3GNRHR, AR, CHKB, CFTR
29n acetylcysteine449.3CHKB, TF, AR, CFTR
30levodopa44 1210.3PRL, AR, CHKB, TF
31cocaine44 1210.3CHKB, AR, PRL, TF
32paraffin449.2CFTR, CHKB, AR, TF
33pge2449.2TF, CFTR, CHKB, AR
34norepinephrine44 25 1211.2TF, CFTR, PRL, CHKB
35dihydrotestosterone44 29 25 1212.2SRD5A2, PRL, CHKB, AR, GNRHR
36progesterone44 29 60 25 1213.2SRD5A2, GNRHR, PRL, AR
37aspartate449.2CFTR, AR, TF, CHKB
38estradiol44 25 1211.2AR, GNRHR, CHKB, PRL, SRD5A2
39agar449.0TF, AR, CHKB
40glutamine449.0SRD5A2, AR, TF, CFTR, CHKB
41ascorbic acid44 2510.0GSTT1, AR, CHKB, CFTR, TF
42alanine449.0SRD5A2, CHKB, GNRHR, CFTR, TF
43tamoxifen44 50 29 1212.0TF, CHKB, GNRHR, AR, PRL
44glutamate448.9AR, CHKB, GNRHR, CFTR, TF
45dopamine44 29 25 1211.9PRL, CHKB, GNRHR, CFTR, TF
46epinephrine44 25 1210.9TF, AR, CHKB, CFTR, PRL
47steroid448.8GNRHR, AR, GSTT1, SRD5A2, PRL, CHKB
48arginine448.8GNRHR, PRL, GSTT1, SRD5A2, AR, CHKB
49estrogen447.9TF, GSTT1, AR, SRD5A2, CFTR, PRL
50testosterone44 60 25 1210.9DAZ4, DAZ1, CFTR, CHKB, PRL, SRD5A2

GO Terms for genes affiliated with Oligospermia

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Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell differentiationGO:0301549.0SRD5A2, DAZ2, DAZ4, DAZ1
2multicellular organismal developmentGO:0072757.9TSSK6, GNRHR, DAZ2, DAZ4, DAZ1

Products for genes affiliated with Oligospermia

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Sources for Oligospermia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet