Aliases & Classifications for Oligospermia

MalaCards integrated aliases for Oligospermia:

Name: Oligospermia 12 28 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14228
ICD10 32 N46.1 N46.11
ICD9CM 34 606.1
MeSH 41 D009845
NCIt 46 C34860
UMLS 69 C0028960

Summaries for Oligospermia

MalaCards based summary : Oligospermia is related to spermatogenic failure, y-linked, 2 and azoospermia. An important gene associated with Oligospermia is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Metformin and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and pituitary, and related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Oligospermia

Diseases related to Oligospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure, y-linked, 2 31.9 DAZ1 DAZ4
2 azoospermia 30.5 AR CFTR DAZ1 DAZ4
3 infertility 30.2 DAZ1 DAZ4 KLHL10 PRL
4 varicocele 29.9 GSTM1 GSTT1 PRL
5 male infertility 29.7 AR CFTR DAZ1 DAZ4
6 gynecomastia 29.6 AR PRL
7 cryptorchidism, unilateral or bilateral 29.5 AR DAZ1 GNRHR
8 bronchiectasis oligospermia 11.9
9 y chromosome infertility 11.3
10 androgen insensitivity, partial 11.0
11 prostatic adenoma 10.3 AR PRL
12 androgenic alopecia 10.3 AR PRL
13 sex differentiation disease 10.3 AR PRL
14 partial deletion of y 10.2 DAZ1 DAZ4
15 johanson-blizzard syndrome 10.2 CFTR UBR2
16 spermatogenic failure, x-linked, 1 10.2 DAZ1 DAZ4
17 testicular germ cell cancer 10.1 AR KITLG
18 hearing loss, noise-induced 10.1 GSTM1 GSTT1
19 sister chromatid exchange, frequency of 10.0 GSTM1 GSTT1
20 isolated cleft lip 10.0 GSTM1 GSTT1
21 oral leukoplakia 10.0 GSTM1 GSTT1
22 drug-induced hepatitis 10.0 GSTM1 GSTT1
23 cervicitis 10.0
24 leukoplakia 10.0 GSTM1 GSTT1
25 mutagen sensitivity 9.9 GSTM1 GSTT1
26 arteritic anterior ischemic optic neuropathy 9.9 GSTM1 GSTT1
27 senile cataract 9.9 GSTM1 GSTT1
28 blood group, i system 9.9
29 impotence 9.9
30 pustulosis of palm and sole 9.9
31 psoriasis 9.9
32 bronchiectasis 9.9
33 diffuse gastric cancer 9.9 GSTM1 GSTT1
34 xeroderma pigmentosum, complementation group d 9.9 GSTM1 GSTT1
35 asbestosis 9.8 GSTM1 GSTT1
36 ischemic optic neuropathy 9.8 GSTM1 GSTT1
37 scabies 9.8 GSTM1 KITLG
38 male reproductive system disease 9.8 AR CFTR DAZ1 DAZ4
39 gonadal disease 9.8 AR GNRHR
40 oral submucous fibrosis 9.8 GSTM1 GSTT1
41 cataract 32, multiple types 9.7
42 schizophrenia 9.7
43 aging 9.7
44 infant gynecomastia 9.7
45 hypogonadism 9.7
46 testicular cancer 9.7
47 hyperglycemia 9.7
48 hypereosinophilic syndrome 9.7
49 transmitted_by 9.7
50 pustular psoriasis 9.7

Comorbidity relations with Oligospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to Oligospermia

Symptoms & Phenotypes for Oligospermia

MGI Mouse Phenotypes related to Oligospermia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 KLHL10 PRL PYGO2 UBR2 AR CFTR
2 reproductive system MP:0005389 9.23 AR CFTR GNRHR KITLG KLHL10 PRL

Drugs & Therapeutics for Oligospermia

Drugs for Oligospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 4091 14219
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
3
Enclomiphene Investigational Phase 4 15690-57-0
4 Anticoagulants Phase 4
5 Calcium, Dietary Phase 4,Phase 2
6 Chelating Agents Phase 4
7 Chorionic Gonadotropin Phase 4
8 Clomiphene Phase 4
9 Estrogen Antagonists Phase 4,Phase 3
10 Estrogen Receptor Modulators Phase 4
11 Estrogens Phase 4,Phase 3
12 Fertility Agents Phase 4
13 Hormone Antagonists Phase 4,Phase 3
14 Hormones Phase 4,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
16 Hypoglycemic Agents Phase 4
17 insulin Phase 4
18 Insulin, Globin Zinc Phase 4
19 Selective Estrogen Receptor Modulators Phase 4
20 Zuclomiphene Phase 4
21 Citrate Nutraceutical Phase 4
22
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
23
Methyltestosterone Approved Phase 3 58-18-4 6010
24
Testosterone Approved, Investigational Phase 3 58-22-0 6013
25
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
26
Menthol Approved Phase 3 2216-51-5 16666
27
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 143 6006
30 Ginger Approved, Nutraceutical Phase 3
31 English walnut Approved, Nutraceutical Phase 2, Phase 3
32 Micronutrients Phase 2, Phase 3
33 Trace Elements Phase 2, Phase 3
34 Vitamins Phase 2, Phase 3
35 Aromatase Inhibitors Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37 Hematinics Phase 2, Phase 3
38 Vitamin B Complex Phase 2, Phase 3
39 Testosterone 17 beta-cypionate Phase 3
40
Testosterone enanthate Phase 3 315-37-7 9416
41 Testosterone undecanoate Phase 3
42 Anabolic Agents Phase 3
43 Androgens Phase 3
44 Antineoplastic Agents, Hormonal Phase 3
45 Estradiol 17 beta-cypionate Phase 3
46 Estradiol 3-benzoate Phase 3
47 Estradiol valerate Phase 3 979-32-8
48 Polyestradiol phosphate Phase 3
49 Folate Nutraceutical Phase 2, Phase 3
50 Inositol Nutraceutical Phase 2, Phase 3

Interventional clinical trials:

(show all 33)

# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 7 NUTS Study. Diet Modification and Male Fertility. Unknown status NCT02063256 Phase 2, Phase 3
5 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
6 Myo-inositol on Human Semen Parameters Completed NCT01828710 Phase 2, Phase 3
7 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
8 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Recruiting NCT02998593 Phase 3 Bahman capsules;Placebo
9 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
10 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
11 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
12 A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count Completed NCT02234206 Phase 2 Chandrakanthi Choornam (CKC)
13 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
14 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
15 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
16 Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality Unknown status NCT01520584
17 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173
18 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
19 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799
20 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482
21 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588
22 Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men Completed NCT01239186
23 Genetic Studies Spermatogenic Failure Completed NCT00548977
24 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
25 ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa Completed NCT03033563
26 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
27 Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage. Completed NCT00447395
28 Severe Male Factor Infertility Management Recruiting NCT02752555
29 Sperm Pathology Samples and Morphokinetics Recruiting NCT02155179
30 Fertility Preservation in Cases of Klinefelter Syndrome. Recruiting NCT01918280
31 Preimplantation Genetic Screening in Patients With Male Factor Infertility Not yet recruiting NCT02941965
32 Effect of Cannabis Consumption on Sperm Nuclear Quality in Infertile Men Not yet recruiting NCT02932527
33 Ramipril for the Treatment of Oligospermia Terminated NCT01856361 Ramipril;Placebo

Search NIH Clinical Center for Oligospermia

Cochrane evidence based reviews: oligospermia

Genetic Tests for Oligospermia

Genetic tests related to Oligospermia:

# Genetic test Affiliating Genes
1 Oligospermia 28

Anatomical Context for Oligospermia

MalaCards organs/tissues related to Oligospermia:

38
Bone, Bone Marrow, Pituitary, Testis

Publications for Oligospermia

Articles related to Oligospermia:

(show top 50) (show all 186)
# Title Authors Year
1
Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology. ( 29051002 )
2018
2
Protective effect of L-carnitine and L-arginine against busulfan-induced oligospermia in adult rat. ( 28444774 )
2017
3
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. ( 28367414 )
2017
4
Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia. ( 29404532 )
2017
5
Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. ( 28730893 )
2017
6
Re: Higher Pregnancy Rates Using Testicular Sperm in Men with Severe Oligospermia. ( 27597099 )
2016
7
A Role for Heterozygosity of NF-d998B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia. ( 27041523 )
2016
8
Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ( 26940145 )
2016
9
A novel nomogram for prediction of spermatogenic improvement following empiric medical therapy for moderate-severe oligospermia. ( 26892053 )
2016
10
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia. ( 27812445 )
2016
11
Re: Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. ( 25986825 )
2015
12
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. ( 26345837 )
2015
13
Higher pregnancy rates using testicular sperm in men with severe oligospermia. ( 26363389 )
2015
14
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia. ( 25109708 )
2014
15
Polymorphism in DNMT1 may modify the susceptibility to oligospermia. ( 24631383 )
2014
16
Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia. ( 25536748 )
2014
17
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: aA randomized phase II clinical trial comparing topical testosterone. ( 25044085 )
2014
18
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. ( 24369145 )
2014
19
Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China. ( 25532576 )
2014
20
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. ( 25106941 )
2014
21
Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. ( 24756080 )
2014
22
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up. ( 23384712 )
2013
23
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. ( 24034937 )
2013
24
[Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. ( 23732668 )
2013
25
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. ( 23885232 )
2013
26
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. ( 24083421 )
2013
27
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. ( 24002933 )
2013
28
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. ( 22905450 )
2012
29
Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. ( 23162296 )
2012
30
Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 22378155 )
2012
31
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. ( 21918533 )
2012
32
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. ( 23141270 )
2012
33
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). ( 21382069 )
2011
34
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. ( 20078516 )
2010
35
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. ( 19338535 )
2009
36
[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. ( 20218307 )
2009
37
Azoospermia and severe oligospermia in testicular cancer. ( 19499754 )
2009
38
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. ( 18555230 )
2008
39
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? ( 17982752 )
2008
40
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. ( 18097510 )
2008
41
Ring chromosome 12 and severe oligospermia: a case report. ( 17880954 )
2008
42
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 18399835 )
2008
43
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. ( 17941933 )
2008
44
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. ( 19062477 )
2008
45
[Genetic polymorphism of glutathione S-transferase T1 associated with idiopathic azoospermia and oligospermia]. ( 17569254 )
2007
46
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). ( 17218411 )
2007
47
Gynaecomastia with oligospermia: an unusual complication of low-dose methotrexate for pustular psoriasis. ( 16309512 )
2006
48
A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia. ( 16968799 )
2006
49
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. ( 16864151 )
2006
50
Oral androstenedione-induced impotence and severe oligospermia. ( 16009183 )
2005

Variations for Oligospermia

ClinVar genetic disease variations for Oligospermia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Expression for Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for Oligospermia

Pathways related to Oligospermia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.18 AR GSTM1 GSTT1 KITLG
2 10.42 GSTM1 GSTT1
3 10 GSTM1 GSTT1

GO Terms for Oligospermia

Cellular components related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 AR CFTR DAZ1 DAZ4

Biological processes related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fertilization GO:0009566 9.43 AR KLHL10
2 germ cell development GO:0007281 9.4 DAZ1 DAZ4
3 glutathione derivative biosynthetic process GO:1901687 9.37 GSTM1 GSTT1
4 male gonad development GO:0008584 9.33 AR KITLG KLHL10
5 positive regulation of translational initiation GO:0045948 9.32 DAZ1 DAZ4
6 3-UTR-mediated mRNA stabilization GO:0070935 9.26 DAZ1 DAZ4
7 spermatogenesis GO:0007283 9.02 AR DAZ1 DAZ4 KLHL10 UBR2
8 male genitalia morphogenesis GO:0048808 8.96 AR KLHL10

Molecular functions related to Oligospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
2 translation activator activity GO:0008494 8.62 DAZ1 DAZ4

Sources for Oligospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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