MCID: OLG001
MIFTS: 43

Oligospermia malady

Reproductive diseases category

Summaries for Oligospermia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and varicocele. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and finasteride have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Oligospermia

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9Disease Ontology, 11DISEASES, 63UMLS, 23GTR, 46Novoseek, 41NCIt, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

oligospermia 9 11 63
oligozoospermia 9 23 46


External Ids:

Disease Ontology9 DOID:14228
NCIt41 C34860
MeSH36 D009845
ICD9CM28 606.1

Related Diseases for Oligospermia

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18GeneCards, 19GeneDecks
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Diseases related to Oligospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia30.7AZF1, DAZ2, DAZ4, DAZ1, CFTR, TSSK6
2varicocele30.6AZF1, PRL
3infertility30.5AR, GSTT1, PRL, GNRHR, CFTR, AZF1
4y chromosome infertility30.4DAZ1
5sertoli cell-only syndrome30.3DAZ1, DAZ2
6male infertility30.2AR, PRL, CFTR
7cryptorchidism30.0AR, AZF1, DAZ1
8gynecomastia29.9AR, SRD5A2, PRL
9hypogonadism29.8TF, GNRHR, PRL, AR
10cervicitis10.2
11bronchiectasis oligospermia10.2
12bronchiectasis10.1
13impotence10.1
14psoriasis10.1
15blindness10.1
16smith magenis syndrome10.1DAZ1, AZF1
17penis agenesis10.0AR, SRD5A2
18androgenic alopecia10.0SRD5A2, AR
19androgen insensitivity syndrome10.0AR, SRD5A2
20pseudohermaphroditism10.0AR, SRD5A2
21nutritional deficiency disease10.0CFTR, TF
22hypospadias10.0AR, SRD5A2
23galactosemia10.0CHKB, TF
24neuromuscular disease10.0GNRHR, CHKB, AR
25precocious puberty10.0PRL, GNRHR
26cystic fibrosis10.0
27hyperprolactinemia10.0
28kallmann syndrome10.0
29obesity10.0
30spinocerebellar ataxia10.0
31testicular disease10.0
32ataxia10.0
33spermatogenic failure 1310.0
34hemochromatosis10.0TF, CFTR
35polycystic ovary syndrome10.0AR, PRL
36motor neuron disease10.0AR, GSTT1
37prostate cancer10.0GNRHR, SRD5A2, GSTT1, AR
38hyperandrogenism10.0AR, PRL
39williams-beuren syndrome10.0
40oculocerebrorenal syndrome10.0
41hyperglycemia10.0
42schizophrenia10.0
43testicular cancer10.0
4448,xxxy syndrome10.0
4548,xxyy syndrome10.0
4649,xxxxy syndrome10.0
47deafness-infertility syndrome10.0
48hypereosinophilic syndrome10.0
49ring chromosome 1210.0
50precocious puberty, male10.0

Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Symptoms for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Oligospermia

Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Search CenterWatch for Oligospermia

Genetic Tests for Oligospermia

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23GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia23

Anatomical Context for Oligospermia

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34MalaCards
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MalaCards organs/tissues related to Oligospermia:

34
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Oligospermia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8CFTR, GNRHR, CHKB, PRL, GSTT1, AR
2MP:00053797.5PYGO2, CFTR, GNRHR, PRL, SRD5A2, KLHL10
3MP:00053896.9AR, PYGO2, CFTR, GNRHR, TSSK6, PRL

Publications for Oligospermia

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53PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. (24369145)
2014
2
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. (23885232)
2013
3
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. (24034937)
2013
4
SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population. (24083421)
2013
5
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
6
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. (21918533)
2012
7
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
8
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
9
Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (20218307)
2009
10
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
11
Ring chromosome 12 and severe oligospermia: a case report. (17880954)
2008
12
Azoospermia after treatment with clomiphene citrate in patients with oligospermia. (18555230)
2008
13
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? (17982752)
2008
14
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). (17218411)
2007
15
An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. (16864151)
2006
16
Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. (16313071)
2005
17
Rapamycin-induced oligospermia. (14501876)
2003
18
Testicular fine needle aspiration cytology for the diagnosis of azoospermia and oligospermia. (10833990)
2000
19
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
20
Biochemical parameters in evaluation of oligospermia. (8089906)
1994
21
Intrauterine insemination as a successful method in the treatment of infertility caused by oligospermia. (7985455)
1993
22
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
23
Episodic luteinizing hormone release in idiopathic oligospermia. (1981212)
1990
24
Immunological studies in patients with oligospermia. (2806606)
1989
25
Cluster of oligospermia among four men occupationally exposed to methylene chloride (MeCl) (2520532)
1989
26
Possibilities of association of azoospermia and oligospermia with some HLA system antigens. (3162459)
1988
27
Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. (3119647)
1987
28
Demonstrated paternity in spite of severe idiopathic oligospermia. (3469106)
1987
29
Tamoxifen and oligospermia. (3938205)
1985
30
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology. (6336098)
1984
31
Differential effect of luteinizing hormone-releasing hormone infusion on testicular steroids in normal men and patients with idiopathic oligospermia. (6430726)
1984
32
Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen. (6404663)
1983
33
Mechanism for delivery of sperm to fimbria in oligospermia. (7201413)
1982
34
The levels of the male serum and seminal fluid prolactin in oligospermia and azoospermia. (6114065)
1981
35
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
36
Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate. (7364070)
1980
37
Effect of synthetic LH-RH and hCG administration on plasma testosterone, androstenedione, and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia. (37185)
1979
38
Oligospermia secondary to mA1llerian duct cyst. Simple surgical cure. (664145)
1978
39
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (916056)
1977
40
Search for transit difficulties in the epididymis for differential diagnosis of oligospermia]. (961325)
1976
41
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (1030546)
1976
42
The first pregnancies after treating of oligospermia by collected and stored human semen. (1143102)
1975
43
Estimation of number, mean size and size distribution of human spermatozoa in oligospermia using a Coulter counter. (4430992)
1974
44
Human menopausal gonadotropins in the treatment of patients with oligospermia. (4422230)
1974
45
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973
46
Treatment of oligospermia with urinary human menopausal gonadotrophin: a preliminary report. (5921777)
1966
47
TREATMENT OF OLIGOSPERMIA WITH LARGE DOSES OF HUMAN CHORIONIC GONADOTROPIN. (14057786)
1963
48
Oligospermia and pregnancy; a study of 34 cases. (13152582)
1954
49
Influence of small doses of stilbestrol on oligospermia. (12991390)
1952
50
Influence of arginine on oligospermia. (20250427)
1947

Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

Search GEO for disease gene expression data for Oligospermia.

Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 52PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1dutasteride46 1211.2AR, SRD5A2
2finasteride46 62 25 1213.0AR, SRD5A2
3leuprolide acetate4610.0GNRHR, PRL
4buserelin46 30 1212.0GNRHR, PRL
5streptomycin52 46 1212.0TF, GSTT1
6nandrolone decanoate46 1210.9TF, AR
7silver nitrate469.9TF, CFTR
8rsai469.8GSTT1, SRD5A2
9leuprolide46 62 30 1212.8GNRHR, PRL, AR
10Hydrogen carbonate259.8CFTR, TF
11fe3+469.8TF, CHKB
12mgatp469.8CHKB, CFTR
13danazol46 25 1211.8AR, PRL, GNRHR
14gentamicin46 1210.7CFTR, TF
15triamcinolone acetonide46 3010.7CFTR, TF
16cyproteroneacetate469.7PRL, AR
17androstenedione46 2510.7PRL, SRD5A2, AR
18bicarbonate469.7TF, CFTR, CHKB
19polyethylene glycol469.6PRL, CHKB, TF
20citrate469.6TF, CFTR, CHKB
21adenine46 25 1211.6AR, SRD5A2, TF
22levonorgestrel46 62 30 1212.5PRL, AR
23vitamin d469.5CFTR, CHKB, SRD5A2, AR
24thyroxine46 2510.5TF, CHKB, PRL
25valine469.4CFTR, SRD5A2, GSTT1, AR
26doxorubicin46 52 1211.4CFTR, GNRHR, GSTT1, AR
27gnrh469.3AR, PRL, GNRHR, CFTR
28adenylate469.3CFTR, GNRHR, CHKB, AR
29n acetylcysteine469.3TF, CFTR, CHKB, AR
30levodopa46 1210.3AR, PRL, CHKB, TF
31cocaine46 1210.3AR, PRL, CHKB, TF
32paraffin469.2TF, CFTR, CHKB, AR
33pge2469.2AR, CHKB, CFTR, TF
34norepinephrine46 25 1211.2PRL, CHKB, CFTR, TF
35dihydrotestosterone46 30 25 1212.2GNRHR, CHKB, PRL, SRD5A2, AR
36progesterone46 30 62 25 1213.2GNRHR, PRL, SRD5A2, AR
37aspartate469.2TF, CFTR, CHKB, AR
38estradiol46 25 1211.2GNRHR, CHKB, PRL, SRD5A2, AR
39agar469.0AR, CHKB, TF
40glutamine469.0TF, CFTR, CHKB, SRD5A2, AR
41ascorbic acid46 2510.0TF, CFTR, CHKB, GSTT1, AR
42alanine469.0TF, CFTR, GNRHR, CHKB, SRD5A2
43tamoxifen46 52 30 1212.0TF, GNRHR, CHKB, PRL, AR
44glutamate468.9TF, CFTR, GNRHR, CHKB, AR
45dopamine46 30 25 1211.9PRL, CHKB, GNRHR, CFTR, TF
46epinephrine46 25 1210.9AR, PRL, CHKB, CFTR, TF
47steroid468.8GNRHR, CHKB, PRL, SRD5A2, GSTT1, AR
48arginine468.8GNRHR, CHKB, PRL, SRD5A2, GSTT1, AR
49estrogen467.9TF, CFTR, GNRHR, CHKB, PRL, SRD5A2
50testosterone46 62 25 1210.9AR, DAZ1, DAZ4, CFTR, GNRHR, CHKB

GO Terms for genes affiliated with Oligospermia

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17Gene Ontology
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Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell differentiationGO:0301549.0SRD5A2, DAZ2, DAZ4, DAZ1
2multicellular organismal developmentGO:0072757.9TSSK6, GNRHR, DAZ2, DAZ4, DAZ1

Products for genes affiliated with Oligospermia

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  • Antibodies
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Sources for Oligospermia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet