MCID: OLG001
MIFTS: 38

Oligospermia malady

Summaries for Oligospermia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and infertility. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary.

Aliases & Classifications for Oligospermia

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8Disease Ontology, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

oligospermia 8 10 60
oligozoospermia 8 22 44


External Ids:

Disease Ontology8 DOID:14228
NCIt39 C34860
MeSH34 D009845
ICD9CM27 606.1

Related Diseases for Oligospermia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Clinical Features for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oligospermia

Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Search CenterWatch for Oligospermia

Genetic Tests for Oligospermia

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22GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia22

Anatomical Context for Oligospermia

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32MalaCards
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MalaCards organs/tissues related to Oligospermia:

32
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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Publications for Oligospermia

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50PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. (24369145)
2014
2
Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. (23732668)
2013
3
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
4
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. (20078516)
2010
5
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
6
Azoospermia and severe oligospermia in testicular cancer. (19499754)
2009
7
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
8
Ring chromosome 12 and severe oligospermia: a case report. (17880954)
2008
9
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. (18097510)
2008
10
The role of manix in the management of idiopathic oligospermia. A pilot study at the Lagos University Teaching Hospital. (19062477)
2008
11
Creatine kinase as an indicator of sperm quality and maturity in men with oligospermia. (11549497)
2001
12
Testicular fine needle aspiration cytology for the diagnosis of azoospermia and oligospermia. (10833990)
2000
13
Effects of four methods of sperm preparation on motion characteristics and nitric oxide concentration in laboratory-prepared oligospermia. (11155759)
2000
14
Azoospermia and oligospermia among a large cohort of DBCP applicators in 12 countries. (10330512)
1999
15
Intracytoplasmic sperm injection: a treatment for extreme oligospermia. (8709295)
1996
16
Modulation of sperm membrane conformation by pentoxifylline in oligospermia: a biophysical investigation of sperm membrane in vitro. (8780691)
1996
17
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
18
Immunological studies in patients with oligospermia. (2806606)
1989
19
Possibilities of association of azoospermia and oligospermia with some HLA system antigens. (3162459)
1988
20
Case reports of individuals with oligospermia and methylene chloride exposures. (2980397)
1988
21
Paradoxical suppression of spermatogenesis during tamoxifen treatment of oligospermia. (2828124)
1988
22
Treatment of severe oligospermia with human chorionic gonadotropin/human menopausal gonadotropin: a placebo-controlled, double blind trial. (3119647)
1987
23
The effects of mesterolone on sperm count in idiopathic oligospermia. (2887529)
1987
24
Bronchiectasis and oligospermia: two families. (3704974)
1986
25
Tamoxifen and oligospermia. (3938205)
1985
26
Differential effect of luteinizing hormone-releasing hormone infusion on testicular steroids in normal men and patients with idiopathic oligospermia. (6430726)
1984
27
Comparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline, and testosterone rebound therapy for the treatment of idiopathic oligospermia. (6411497)
1983
28
The levels of the male serum and seminal fluid prolactin in oligospermia and azoospermia. (6114065)
1981
29
Recovery from severe oligospermia after exposure to dibromochloropropane. (6780379)
1981
30
Macrophage cells in the semen of a dog with oligospermia. (7336540)
1981
31
Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate. (7364070)
1980
32
Clomiphene treatment of infertile men: failure of response with idiopathic oligospermia. (7418894)
1980
33
Psoriasis, methotrexate, and oligospermia. (7356357)
1980
34
Effect of synthetic LH-RH and hCG administration on plasma testosterone, androstenedione, and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia. (37185)
1979
35
Effect of clomiphene citrate on plasma levels of immunoreactive luteinizing hormone-releasing hormone, gonadotropin, and testosterone in normal subjects and in patients with idiopathic oligospermia. (348501)
1978
36
The hormone response to a synthetic androgen (mesterolone) in oligospermia. (872444)
1977
37
Search for transit difficulties in the epididymis for differential diagnosis of oligospermia]. (961325)
1976
38
The treatment of oligospermia with various dosage regimes of gonadotropins. (6357)
1975
39
Pituitary gonadotropin response to luteinizing hormone-releasing hormone (LH-RH) in males with azo- and oligospermia. (4378)
1975
40
Relationship between spermatogenesis and serum gonadotropin levels in azoospermia and oligospermia. (5020414)
1972
41
Effect of arginine on oligospermia. (5435745)
1970
42
Treatment of normogonadotropic oligospermia with large doses of chorionic gonadotropin. (5726257)
1968
43
Ligature of left spermatic vein in the treatment of oligospermia. (5660247)
1968
44
Effect of oligospermia in insemination and fecundation in fertile women. (13846943)
1960
45
Sterility due to oligospermia and hypokinesis of the sperm. New method of treatment. (13725604)
1960
46
Oligospermia; a clinical study of treatment with methylandrostenediol. (13375713)
1956
47
Influence of small doses of stilbestrol on oligospermia. (12991390)
1952
48
Vitamin A therapy in oligospermia. (14945537)
1952
49
Oligospermia associated with impaired dark adaptation. (18107709)
1948
50
Constant oligospermia and periodic oligospermia. (18894812)
1948

Genetic Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

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Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dutasteride44 1111.2AR, SRD5A2
2leuprolide44 59 28 1113.1GNRHR, AR
3nandrolone decanoate44 1111.1AR, TF
4finasteride44 59 11 2412.9AR, SRD5A2
5dihydrotestosterone44 28 11 2412.8GNRHR, AR, CHKB, SRD5A2
6levodopa44 1110.7CHKB, AR, TF
7valine449.7CSNK2A2, AR, SRD5A2, GSTT1
8adenine44 11 2411.7SRD5A2, AR, TF
9ascorbic acid44 2410.5GSTT1, CHKB, AR, TF
10estradiol44 11 2411.5GNRHR, CSNK2A2, AR, CHKB, SRD5A2
11tamoxifen44 49 28 1112.5CHKB, AR, TF, CSNK2A2, GNRHR
12vitamin d449.5SRD5A2, CHKB, AR, CSNK2A2
13cocaine44 1110.4CHKB, AR, TF
14steroid449.2GNRHR, CSNK2A2, AR, CHKB, SRD5A2, GSTT1
15testosterone44 59 11 2412.2GNRHR, AR, CHKB, DAZ4, DAZ1, SRD5A2
16arginine449.2GSTT1, SRD5A2, CHKB, AR, CSNK2A2, GNRHR
17estrogen449.0GNRHR, CSNK2A2, TF, AR, CHKB, SRD5A2

GO Terms for genes affiliated with Oligospermia

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16Gene Ontology
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Cellular components related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.8DAZ2, HSFX1, MOCS2, PHF7, AR, USP9Y

Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male genitalia morphogenesisGO:0488089.9AR, KLHL10
2male gonad developmentGO:0085849.8SRD5A2, AR, KLHL10
3spermatogenesisGO:0072839.1TSSK4, DAZ2, DAZ1, DAZ4, USP9Y, AR
4cell differentiationGO:0301549.0DAZ4, DAZ1, DAZ2, SRD5A2, TSSK4
5multicellular organismal developmentGO:0072758.9GNRHR, DAZ4, DAZ1, DAZ2, TSSK4, TSSK6

Molecular functions related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:0001669.1DAZ2, DAZ1, DAZ4, RBMY1A1, MOCS2

Products for genes affiliated with Oligospermia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet