MCID: OLG001
MIFTS: 38

Oligospermia malady

Summaries for Oligospermia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oligozoospermia, refers to semen with a low concentration of sperm and is a common finding in male... more...

MalaCards: Oligospermia, also known as oligozoospermia, is related to azoospermia and infertility. An important gene associated with Oligospermia is AZF1 (azoospermia factor 1). The compounds dutasteride and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include testis and pituitary.

Aliases & Classifications for Oligospermia

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

oligospermia 8 10 60
oligozoospermia 8 22 44


External Ids:

Disease Ontology8 DOID:14228
NCIt39 C34860
MeSH34 D009845
ICD9CM27 606.1

Related Diseases for Oligospermia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Oligospermia:



Diseases related to oligospermia

Clinical Features for Oligospermia

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Drugs & Therapeutics for Oligospermia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oligospermia

Drug clinical trials:

Search ClinicalTrials for Oligospermia

Search NIH Clinical Center for Oligospermia

Search CenterWatch for Oligospermia

Genetic Tests for Oligospermia

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22GTR
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Genetic tests related to Oligospermia:

id Genetic test Affiliating Genes
1 Oligozoospermia22

Anatomical Context for Oligospermia

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32MalaCards
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MalaCards organs/tissues related to Oligospermia:

32
Testis, Pituitary

Animal Models for Oligospermia or affiliated genes

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Publications for Oligospermia

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50PubMed
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Articles related to Oligospermia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
De novo 15.5-Mb Interstitial Deletion in 5p in a Male Ascertained by Oligospermia. (23885232)
2013
2
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality. (24034937)
2013
3
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
4
Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. (21918533)
2012
5
Severe oligospermia associated with a unique balanced reciprocal translocation t(6;12)(q23;q24.3): male infertility related to t(6;12). (21382069)
2011
6
Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (20218307)
2009
7
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). (17218411)
2007
8
Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. (16313071)
2005
9
Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. (15537917)
2004
10
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
11
Steroid 5alpha-reductase 2 gene melting polymorphisms in male subjects with azoospermia or oligospermia. (10368476)
1999
12
45,X/46,X,r(Y) karyotype transmitted by father to son after intracytoplasmic sperm injection for oligospermia. A case report. (10442333)
1999
13
New options for managing severe oligospermia and azoospermia. (8732741)
1996
14
Abnormal physical architecture of the lipophilic domains of human sperm membrane in oligospermia: a logical cause for low fertility profiles. (8292030)
1994
15
Lipid metabolism in young males with hypotestosteronaemia and oligospermia prior to, during, and after treatment. (1938220)
1991
16
Over-expression of superoxide dismutase and lack of surface-thiols in spermatozoa: inherent defects in oligospermia. (1847045)
1991
17
Levamisole treatment of oligospermia. (2091439)
1990
18
Subfertile men with severe oligospermia: outcome of management. (3240756)
1988
19
Serum and seminal plasma prolactin concentrations in men with normospermia, oligospermia, or azoospermia. (3335260)
1988
20
Demonstrated paternity in spite of severe idiopathic oligospermia. (3469106)
1987
21
Sperm processing and intrauterine insemination for oligospermia. (3617271)
1987
22
Serum bioactive follicle-stimulating hormone in men with idiopathic azoospermia and oligospermia. (3116028)
1987
23
Gonadotrophin suppression by the synthetic androgen mesterolone in idiopathic oligospermia. (3084373)
1986
24
The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology. (6336098)
1984
25
Treatment of idiopathic oligospermia. (6692957)
1984
26
Hormone levels in the reproductive system of normospermic men and patients with oligospermia and varicocele. (6430947)
1984
27
Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen. (6404663)
1983
28
Simultaneous treatment of the wife in infertile couples with oligospermia. (6617913)
1983
29
Leydig cell function in idiopathic oligospermia. (6773819)
1980
30
Cortisone acetate versus clomiphene citrate in per-germinal idiopathic oligospermia. (439212)
1979
31
The cervical cap self-applied in the treatment of severe oligospermia. (421922)
1979
32
Dynamic evaluation of prolactin secretion in patients with oligospermia: effects of treatment with metergoline. (105938)
1979
33
Bromocriptine treatment of oligospermia: a double blind study. (519877)
1979
34
Homologous artificial insemination and oligospermia. (1248659)
1976
35
Estimation of number, mean size and size distribution of human spermatozoa in oligospermia using a Coulter counter. (4430992)
1974
36
Human menopausal gonadotropins in the treatment of patients with oligospermia. (4422230)
1974
37
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973
38
Treatment of oligospermia with the amino acid arginine. (4803052)
1973
39
Treatment of oligospermia with the amino acid arginine. (4725736)
1973
40
Treatment of oligospermia by freezing and concentrating semen. (4362383)
1972
41
Idiopathic oligospermia: control observations and response to cisclomiphene. (5036593)
1972
42
Plasma and urinary follicle-stimulating hormone levels in oligospermia. (5008226)
1972
43
Meiotic studies of the ejaculated seminal fluid of humans with normal sperm count and oligospermia. (4937211)
1971
44
The effect of human postmenopausal gonadotropins on infertile men with severe oligospermia. (6073929)
1967
45
Schizophrenia, oligospermia, and the phenothiazines. (6024061)
1967
46
Effect of clomiphene citrate on oligospermia. (4951883)
1967
47
Analysis of ultimate fertility in 100 untreated cases of oligospermia and sterility. (13704845)
1960
48
Oligospermia and pregnancy; a study of 34 cases. (13152582)
1954
49
Treatment of oligospermia with testosterone propionate. (14928249)
1951
50
Management of infertility associated with oligospermia. (20250336)
1947

Genetic Variations for Oligospermia

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Expression for genes affiliated with Oligospermia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oligospermia

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Pathways for genes affiliated with Oligospermia

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Compounds for genes affiliated with Oligospermia

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Oligospermia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dutasteride44 1111.2SRD5A2, AR
2leuprolide44 59 28 1113.1AR, GNRHR
3nandrolone decanoate44 1111.1AR, TF
4finasteride44 59 11 2412.9SRD5A2, AR
5dihydrotestosterone44 28 11 2412.8SRD5A2, CHKB, AR, GNRHR
6levodopa44 1110.7CHKB, AR, TF
7valine449.7GSTT1, AR, CSNK2A2, SRD5A2
8adenine44 11 2411.7TF, SRD5A2, AR
9ascorbic acid44 2410.5TF, AR, GSTT1, CHKB
10estradiol44 11 2411.5AR, GNRHR, CSNK2A2, CHKB, SRD5A2
11tamoxifen44 49 28 1112.5CSNK2A2, GNRHR, TF, AR, CHKB
12vitamin d449.5CSNK2A2, SRD5A2, CHKB, AR
13cocaine44 1110.4AR, CHKB, TF
14steroid449.2GSTT1, GNRHR, CSNK2A2, AR, CHKB, SRD5A2
15testosterone44 59 11 2412.2AR, DAZ4, GNRHR, DAZ1, SRD5A2, CHKB
16arginine449.2CHKB, SRD5A2, GSTT1, AR, GNRHR, CSNK2A2
17estrogen449.0CSNK2A2, GSTT1, SRD5A2, CHKB, AR, TF

GO Terms for genes affiliated with Oligospermia

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16Gene Ontology
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Cellular components related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.8DAZ2, HSFX1, MOCS2, PHF7, AR, USP9Y

Biological processes related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male genitalia morphogenesisGO:0488089.9AR, KLHL10
2male gonad developmentGO:0085849.8AR, SRD5A2, KLHL10
3spermatogenesisGO:0072839.1AR, USP9Y, DAZ4, DAZ1, DAZ2, TSSK4
4cell differentiationGO:0301549.0TSSK4, SRD5A2, DAZ2, DAZ1, DAZ4
5multicellular organismal developmentGO:0072758.9TSSK6, GNRHR, DAZ4, DAZ1, DAZ2, TSSK4

Molecular functions related to Oligospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:0001669.1DAZ2, DAZ1, DAZ4, RBMY1A1, MOCS2

Products for genes affiliated with Oligospermia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oligospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet