MCID: ONC002
MIFTS: 48

Onchocerciasis

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Onchocerciasis

MalaCards integrated aliases for Onchocerciasis:

Name: Onchocerciasis 12 50 56 52 3 42 14 69
River Blindness 50 3
Infection by Onchocerca Volvulus 12
Onchocerca Volvulus Infection 12
Onchocerciasis, Ocular 69
Robles' Disease 50
Volvulosis 12

Characteristics:

Orphanet epidemiological data:

56
onchocerciasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11678
ICD10 33 B73
ICD9CM 35 125.3
MeSH 42 D009855
NCIt 47 C34861
SNOMED-CT 64 38539003
Orphanet 56 ORPHA2737
MESH via Orphanet 43 D009855 D015827
UMLS via Orphanet 70 C0029001 C0029002
ICD10 via Orphanet 34 B73
UMLS 69 C0029001

Summaries for Onchocerciasis

CDC : 3 Onchocerciasis, or River Blindness, is a neglected tropical disease (NTD) caused by the parasitic worm Onchocerca volvulus. It is transmitted through repeated bites by blackflies of the genus Simulium. The disease is called River Blindness because the blackfly that transmits the infection lives and breeds near fast-flowing streams and rivers and the infection can result in blindness. In addition to visual impairment or blindness, onchocerciasis causes skin disease, including nodules under the skin or debilitating itching. Worldwide onchocerciasis is second only to trachoma as an infectious cause of blindness.

MalaCards based summary : Onchocerciasis, also known as river blindness, is related to loiasis and skin disease. An important gene associated with Onchocerciasis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ivermectin and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye.

Disease Ontology : 12 A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

Wikipedia : 72 Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm... more...

Related Diseases for Onchocerciasis

Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
id Related Disease Score Top Affiliating Genes
1 loiasis 30.5 IL13 IL4 IL5
2 skin disease 30.5 IL5 RNASE3
3 malaria 27.6 CCL11 CCL5 IL13 IL2 IL4 IL5
4 orbit alveolar rhabdomyosarcoma 10.7 IL4 IL5
5 angioid streaks of choroid 10.7 IL4 IL5
6 allescheriosis 10.7 IL4 IL5
7 visual snow syndrome 10.7 IL2 IL4
8 urethral intrinsic sphincter deficiency 10.7 IL4 IL5
9 papillary follicular thyroid adenocarcinoma 10.7 IL5 RNASE3
10 crustacean allergy 10.6 IL5 RNASE3
11 pmm2-congenital disorder of glycosylation 10.6 IL2 IL4
12 histoplasmosis retinitis 10.6 IL4 IL5
13 subacute bacterial endocarditis 10.6 IL5 RNASE3
14 vulvar disease 10.6 CCL5 RNASE3
15 lymphocytic colitis 10.6 IL2 IL4
16 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.6 IL4 IL5
17 primary syringomyelia 10.6 EPX RNASE3
18 oropharyngeal cancer, childhood 10.6 CCL5 IL4
19 parametritis 10.5 IL2 RBP3
20 cecum adenoma 10.5 EPX RNASE3
21 cytoplasmic body myopathy 10.5 IL13 IL5
22 goat milk allergy 10.5 IL13 IL4
23 aortic arch interruption 10.5 IL13 IL5
24 signet ring cell adenocarcinoma 10.5 IL5 RNASE3
25 philophthalmiasis 10.5 IL4 IL5
26 nonspecific interstitial pneumonia 10.5 CALR IL5
27 marasmus 10.5 IL4 IL5 RNASE3
28 orbital plasma cell granuloma 10.5 IL4 IL5 RNASE3
29 cow milk allergy 10.5 IL13 IL4
30 nut allergy 10.4 IL4 IL5 RNASE3
31 cyclothymic disorder 10.4 CALR IL5
32 abnormal retinal correspondence 10.4 IL2 IL4 IL5
33 myofibroma 10.4 IL13 IL5
34 malignant hyperthermia 10.4 IL2 IL4 IL5
35 indian tick typhus 10.4 CCL5 IL13
36 tularemia 10.4 IL2 IL4
37 clostridium difficile colitis 10.4 EPX RNASE3
38 whistling face syndrome, recessive form 10.4 IL2 IL5 RNASE3
39 gonadal disease 10.4 IL2 IL4
40 filariasis 10.4
41 dissociated nystagmus 10.4 EPX IL4 IL5
42 exudative vitreoretinopathy 2, x-linked 10.4 IL13 IL5
43 esophagus small cell carcinoma 10.3 IL13 IL5
44 carotid artery dissection 10.3 CCL5 IL2 IL4
45 early-onset zonular cataract 10.3 IL4 RBP3
46 gastric ulcer 10.3 CCL5 IL2 IL5
47 vascular dementia 10.3 CCL5 IL4
48 cherry allergy 10.3 IL13 IL4 IL5
49 abdominal tuberculosis 10.3 IL13 IL4 IL5
50 glucose intolerance 10.2 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to Onchocerciasis

Symptoms & Phenotypes for Onchocerciasis

Drugs & Therapeutics for Onchocerciasis

Drugs for Onchocerciasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 4,Phase 3,Phase 2 70288-86-7 6474909 46936176
2 Anticonvulsants Phase 4,Phase 2
3 Anti-Infective Agents Phase 4,Phase 3,Phase 2
4 Antiparasitic Agents Phase 4,Phase 3,Phase 2
5
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
6 Vitamins Phase 3,Phase 2
7 Anthelmintics Phase 3,Phase 2,Phase 1
8 Antimitotic Agents Phase 3
9 Antiprotozoal Agents Phase 3,Phase 2
10 Milbemycin Phase 3,Phase 2
11
Phenytoin Approved, Vet_approved Phase 2 57-41-0 1775
12
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
13
Azithromycin Approved Phase 2 83905-01-5 55185 53477736 447043
14
Rifampin Approved Phase 2 13292-46-1 5458213 5381226
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
16
Pyridoxal Approved, Nutraceutical Phase 2 66-72-8 1050
17
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
18 Antimanic Agents Phase 2
19 Central Nervous System Depressants Phase 2
20 Diuretics, Potassium Sparing Phase 2
21 GABA Agents Phase 2
22 Micronutrients Phase 2
23 Neurotransmitter Agents Phase 2
24 Psychotropic Drugs Phase 2
25 Sodium Channel Blockers Phase 2
26 Trace Elements Phase 2
27 Tranquilizing Agents Phase 2
28 Vitamin B 6 Phase 2
29 Vitamin B Complex Phase 2
30 Anti-Bacterial Agents Phase 2
31 Antibiotics, Antitubercular Phase 2
32 Antitubercular Agents Phase 2
33 Cytochrome P-450 CYP3A Inducers Phase 2
34 Nucleic Acid Synthesis Inhibitors Phase 2
35 Antimalarials Phase 2
36 Artemisinine Phase 2
37 Artemisinins Phase 2
38
Dihydroartemisinin Phase 2 71939-50-9 6918483
39
Piperaquine Phase 2 4085-31-8 5079497
40 Imatinib Mesylate Phase 2 123596
41 Protein Kinase Inhibitors Phase 2
42 Folate Nutraceutical Phase 2
43 Vitamin B9 Nutraceutical Phase 2
44
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
45
Diethylcarbamazine Approved, Vet_approved 90-89-1 3052
46
Suramin Approved 145-63-1 5361
47
Mebendazole Approved, Vet_approved 31431-39-7 4030
48
Piperazine Approved, Vet_approved 110-85-0 4837
49 Lipoxygenase Inhibitors
50 Piperazine citrate

Interventional clinical trials:

(show all 19)

id Name Status NCT ID Phase Drugs
1 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4 Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
4 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
5 Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda — 2012 Unknown status NCT01730313 Phase 2 Pyridoxine;Sodium Valproate;Phenytoin;Placebo
6 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
7 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
8 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
9 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
10 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
11 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
12 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
13 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Recruiting NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
14 Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis Recruiting NCT02899936 3 drug dose - IDA;2 drug dose - DA
15 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
16 Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia Active, not recruiting NCT01905436 Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
17 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Active, not recruiting NCT01905423 Albendazole and diethylcarbamazine
18 Lymphatic Filariasis (LF) in Ivory Coast Active, not recruiting NCT02974049 Albendazole;Ivermectin;Diethylcarbamazine
19 Prevalence of LF Infection in Districts Not Included in LF Control Activities Not yet recruiting NCT03131401

Search NIH Clinical Center for Onchocerciasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: onchocerciasis

Genetic Tests for Onchocerciasis

Anatomical Context for Onchocerciasis

MalaCards organs/tissues related to Onchocerciasis:

39
Skin, Testes, Eye, Neutrophil, Breast, T Cells, Lymph Node

Publications for Onchocerciasis

Articles related to Onchocerciasis:

(show top 50) (show all 647)
id Title Authors Year
1
A new methodology for sampling blackflies for the entomological surveillance of onchocerciasis in Brazil. ( 28727733 )
2017
2
Onchocerciasis in the Democratic Republic of Congo: Survey of knowledge, attitude and perception in Bandundu province. ( 28215917 )
2017
3
Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis. ( 28381279 )
2017
4
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 28303006 )
2017
5
Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa. ( 28056015 )
2017
6
Skin snips have no role in programmatic evaluations for onchocerciasis elimination: a reply to Bottomley et al. ( 28335815 )
2017
7
River-specific macrogenomic diversity in Simulium guianense s. l. (Diptera: Simuliidae), a complex of tropical American vectors associated with human onchocerciasis. ( 28727841 )
2017
8
Review of Ethiopian Onchocerciasis Elimination Programme. ( 28878430 )
2017
9
The Current Status of Molecular Xenomonitoring for Lymphatic Filariasis and Onchocerciasis. ( 28756911 )
2017
10
Biodiversity of Simulium metallicum sensu lato (Diptera: Simuliidae), a complex of Neotropical vectors associated with human onchocerciasis. ( 28624513 )
2017
11
Evaluation of Community-Directed Operation of Black Fly Traps for Entomological Surveillance of Onchocerca volvulus Transmission in the Madi-Mid North Focus of Onchocerciasis in Northern Uganda. ( 28820716 )
2017
12
Important progress towards elimination of onchocerciasis in the West Region of Cameroon. ( 28774318 )
2017
13
Modelling the health and economic impacts of the elimination of river blindness (onchocerciasis) in Africa. ( 28589011 )
2017
14
Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). ( 28600214 )
2017
15
High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo. ( 28708828 )
2017
16
Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial. ( 28855148 )
2017
17
Evaluation of Onchocerciasis Transmission in Tanzania: Preliminary Rapid Field Results in the Tukuyu Focus, 2015. ( 28722619 )
2017
18
Adherence to ivermectin is more associated with perceptions of community directed treatment with ivermectin organization than with onchocerciasis beliefs. ( 28806785 )
2017
19
Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. ( 28056021 )
2017
20
Is imported onchocerciasis a truly rare entity? Case report and review of the literature. ( 28232074 )
2017
21
Recrudescence of onchocerciasis in the ComoAc valley in Southwest Burkina Faso. ( 27845063 )
2017
22
The esperanza window trap reduces the human biting rate of Simulium ochraceum s.l. in formerly onchocerciasis endemic foci in Southern Mexico. ( 28686665 )
2017
23
The Genomic Architecture of Novel Simulium damnosum Wolbachia Prophage Sequence Elements and Implications for Onchocerciasis Epidemiology. ( 28611731 )
2017
24
Nodding syndrome and epilepsy in onchocerciasis endemic regions: comparing preliminary observations from South Sudan and the Democratic Republic of the Congo with data from Uganda. ( 27005304 )
2016
25
Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis. ( 27752109 )
2016
26
Nodding Syndrome in Onchocerciasis Endemic Areas. ( 27289272 )
2016
27
Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin. ( 27926918 )
2016
28
Cross-border collaboration for neglected tropical disease efforts-Lessons learned from onchocerciasis control and elimination in the Mano River Union (West Africa). ( 27549911 )
2016
29
Evaluation of onchocerciasis seroprevalence in Bioko Island (Equatorial Guinea) after years of disease control programmes. ( 27645887 )
2016
30
Progress towards eliminating onchocerciasis in the WHO Region of the Americas: verification of elimination of transmission in Guatemala. ( 27801556 )
2016
31
Canine ocular onchocerciasis: a retrospective review of the diagnosis, treatment, and outcome of 16 cases in New Mexico (2011-2015). ( 27624855 )
2016
32
Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results. ( 27349645 )
2016
33
Knowledge, attitude and practice of community drug distributors' about onchocerciasis and community directed treatment with ivermectin in Quara district, North Western Ethiopia. ( 27053243 )
2016
34
Onchocerciasis, an undiagnosed disease in Mozambique: identifying research opportunities. ( 27030247 )
2016
35
The Imaramagambo Onchocerciasis Focus in Southwestern Uganda: Interruption of Transmission After Disappearance of the Vector Simulium neavei and Its Associated Freshwater Crabs. ( 27215297 )
2016
36
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. ( 27448085 )
2016
37
Analysis of age-dependent trends in Ov16 IgG4 seroprevalence to onchocerciasis. ( 27296630 )
2016
38
Development and validation of an Onchocerca ochengi microfilarial hamster model for onchocerciasis drug screens. ( 27515037 )
2016
39
Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus. ( 26813296 )
2016
40
Research for new drugs for elimination of onchocerciasis in Africa. ( 27693536 )
2016
41
Comparison of a new visual isothermal nucleic acid amplification test with PCR and skin snip analysis for diagnosis of onchocerciasis in humans. ( 27473357 )
2016
42
Still mesoendemic onchocerciasis in two Cameroonian community-directed treatment with ivermectin projects despite more than 15 years of mass treatment. ( 27842567 )
2016
43
Progress report on the elimination of human onchocerciasis, 2015-2016. ( 27801998 )
2016
44
Onchocerciasis Elimination from Africa: One Step in Northern Sudan. ( 27698270 )
2016
45
A Knowledge, Attitudes and Practices Survey Conducted Three Years after Halting Ivermectin Mass Treatment for Onchocerciasis in Guatemala. ( 27341104 )
2016
46
Onchocerciasis Presenting as a Breast Mass. ( 26945695 )
2016
47
Epidemiological Mapping of Human Onchocerciasis in Transmission Suspected Districts of Bale, Borena, and West Arsi Zones of Eastern Ethiopia. ( 27648069 )
2016
48
Onchocerciasis in Yemen: Time to take action against a neglected tropical parasitic disease. ( 27325293 )
2016
49
Using Community-Level Prevalence of Loa loa Infection to Predict the Proportion of Highly-Infected Individuals: Statistical Modelling to Support Lymphatic Filariasis and Onchocerciasis Elimination Programs. ( 27906982 )
2016
50
Impact of Six Years Community Directed Treatment with Ivermectin in the Control of Onchocerciasis, Western Ethiopia. ( 26942910 )
2016

Variations for Onchocerciasis

Expression for Onchocerciasis

Search GEO for disease gene expression data for Onchocerciasis.

Pathways for Onchocerciasis

Pathways related to Onchocerciasis according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CALR CCL11 CCL5 EPX IL13 IL2
2
Show member pathways
13.48 CCL11 CCL5 CCL7 IL13 IL2 IL4
3
Show member pathways
13.37 CCL11 CCL5 CCL7 IL13 IL2 IL4
4
Show member pathways
13.25 CCL11 CCL5 CCL7 IL13 IL2 IL4
5
Show member pathways
13.2 CCL11 CCL5 IL13 IL2 IL4 IL5
6
Show member pathways
13.12 CCL11 CCL5 CCL7 IL13 IL2 IL4
7
Show member pathways
12.64 CCL5 IL13 IL2 IL4
8
Show member pathways
12.5 CALR CCL11 EPX IL13 IL2 IL4
9
Show member pathways
12.46 IL13 IL2 IL4 IL5
10
Show member pathways
12.16 CCL11 CCL7 IL13 IL4 IL5
11
Show member pathways
12.09 IL13 IL2 IL4 IL5
12
Show member pathways
12.01 IL13 IL2 IL4 IL5
13
Show member pathways
11.91 IL13 IL2 IL5
14
Show member pathways
11.9 CCL11 CCL5 CCL7
15 11.87 IL2 IL4 IL5
16 11.86 CCL11 IL13 IL4
17 11.69 IL13 IL2 IL4 IL5
18 11.66 IL13 IL2 IL4 IL5
19
Show member pathways
11.64 IL2 IL4 IL5
20 11.55 CCL11 IL4 IL5
21 11.45 CCL11 CCL5 IL13 IL4 IL5
22 11.43 CCL5 IL13 IL4
23 11.23 IL2 IL4 IL5
24 11.21 IL13 IL4 IL5
25 11.15 IL13 IL2 IL4 IL5
26 11.09 IL13 IL2
27 11.04 IL13 IL2 IL4 IL5
28 11.03 CCL11 IL13 IL2 IL4 IL5
29 10.76 IL13 IL4 IL5
30 10.4 CCL11 CCL5 CCL7 IL13 IL2 IL4

GO Terms for Onchocerciasis

Cellular components related to Onchocerciasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CALR CCL11 CCL5 CCL7 EPX IL13
2 extracellular space GO:0005615 9.36 CALR CCL11 CCL5 CCL7 EPX IL13
3 cell GO:0005623 9.33 CCL11 CCL7 IL2

Biological processes related to Onchocerciasis according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.97 CCL11 CCL5 CCL7 IL2 IL5
2 positive regulation of cell proliferation GO:0008284 9.96 CALR IL2 IL4 IL5
3 cell-cell signaling GO:0007267 9.9 CCL5 CCL7 IL13 IL2
4 positive regulation of cell migration GO:0030335 9.84 CCL11 CCL5 CCL7
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 CCL11 CCL5 CCL7
6 cellular response to tumor necrosis factor GO:0071356 9.8 CCL11 CCL5 CCL7
7 response to ethanol GO:0045471 9.79 IL13 IL2 IL4
8 inflammatory response GO:0006954 9.77 CCL11 CCL5 CCL7 IL13 IL5
9 cellular response to interleukin-1 GO:0071347 9.74 CCL11 CCL5 CCL7
10 chemokine-mediated signaling pathway GO:0070098 9.73 CCL11 CCL5 CCL7
11 neutrophil chemotaxis GO:0030593 9.72 CCL11 CCL5 CCL7
12 positive regulation of T cell proliferation GO:0042102 9.71 CCL5 IL2 IL4
13 chemotaxis GO:0006935 9.71 CCL11 CCL5 CCL7 IL4
14 cellular response to interferon-gamma GO:0071346 9.69 CCL11 CCL5 CCL7
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.67 IL2 IL4
16 positive regulation of activated T cell proliferation GO:0042104 9.65 IL2 IL4
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 IL13 IL4
18 innate immune response in mucosa GO:0002227 9.64 IL4 RNASE3
19 positive regulation of JAK-STAT cascade GO:0046427 9.64 CCL5 IL5
20 positive regulation of T cell differentiation GO:0045582 9.63 IL2 IL4
21 monocyte chemotaxis GO:0002548 9.63 CCL11 CCL5 CCL7
22 microglial cell activation GO:0001774 9.62 IL13 IL4
23 cellular calcium ion homeostasis GO:0006874 9.62 CALR CCL11 CCL5 CCL7
24 positive regulation of immunoglobulin secretion GO:0051024 9.61 IL2 IL5
25 positive regulation of mast cell degranulation GO:0043306 9.61 IL13 IL4
26 positive regulation of isotype switching to IgG isotypes GO:0048304 9.59 IL2 IL4
27 positive regulation of immunoglobulin production GO:0002639 9.58 IL13 IL4
28 positive regulation of natural killer cell chemotaxis GO:2000503 9.52 CCL5 CCL7
29 negative regulation of T-helper 17 cell differentiation GO:2000320 9.49 IL2 IL4
30 regulation of proton transport GO:0010155 9.48 IL13 IL4
31 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL13 IL4
32 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 CCL5 IL2 IL4
33 eosinophil chemotaxis GO:0048245 9.33 CCL11 CCL5 CCL7
34 positive regulation of B cell proliferation GO:0030890 9.26 IL13 IL2 IL4 IL5
35 immune response GO:0006955 9.17 CCL11 CCL5 CCL7 IL13 IL2 IL4

Molecular functions related to Onchocerciasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 IL2 IL4 IL5
2 cytokine receptor binding GO:0005126 9.32 IL13 IL4
3 cytokine activity GO:0005125 9.17 CCL11 CCL5 CCL7 IL13 IL2 IL4
4 CCR1 chemokine receptor binding GO:0031726 9.16 CCL5 CCL7
5 chemokine activity GO:0008009 9.13 CCL11 CCL5 CCL7

Sources for Onchocerciasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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