MCID: ONC002
MIFTS: 56

Onchocerciasis malady

Infectious diseases category

Summaries for Onchocerciasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards: Onchocerciasis, also known as infection by onchocerca volvulus, is related to schistosomiasis and skin disease. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR-alpha and Chemokine receptors bind chemokines. The drug ivermectin and the compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

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Wikipedia:63 Onchocerciasis (/ˈɒŋkɵsɜrˈsaɪ.əsɨs/ or /ˈɒŋkɵsɜrˈkaɪ.əsɨs/), also known as river... more...

Aliases & Classifications for Onchocerciasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
onchocerciasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

onchocerciasis 8 42 10 44 48 60
infection by onchocerca volvulus 8
onchocerca volvulus infection 8
onchocerciasis, ocular 60
river blindness 42
robles' disease 42
volvulosis 8


External Ids:

Disease Ontology8 DOID:11678
ICD9CM27 125.3
NCIt39 C34861
MeSH34 D009855
ICD10 via Orphanet26 B73
SNOMED-CT56 38539003
SNOMED-CT via Orphanet57 240842000, 38539003
UMLS via Orphanet61 C0029001, C0029002
MESH via Orphanet35 D009855, D015827
ICD1025 B73

Related Diseases for Onchocerciasis

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17GeneCards, 18GeneDecks
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Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis30.6IL5, RNASE3
2skin disease30.2CCL11, CCL27, S100A8, DSG1, RNASE3, IL5
3malaria30.0CCL5
4eosinophilia30.0CCL11, CCL5, CCL27, EPX, RNASE3, RNASE2
5leishmaniasis29.8MPI, IL5
6tuberculosis29.8EPX, LBR, CALR
7dermatitis29.8CCL11, CCL27, DSG1, IL5
8filariasis10.6
9loiasis10.4
10chorioretinitis10.2
11trachoma10.1
12chagas disease10.1
13dracunculiasis10.1
14elephantiasis10.1
15optic nerve disease10.1
16urinary schistosomiasis10.0
17cysticercosis10.0
18intestinal schistosomiasis10.0
19mansonelliasis10.0
20epilepsy syndrome10.0
21optic atrophy10.0
22tetanus10.0
23corneal disease10.0
24diabetes mellitus10.0CALR
25bronchitis10.0RNASE3
26paragonimiasis10.0IL5
27strongyloidiasis10.0IL5
28lupus erythematosus10.0CALR
29celiac disease10.0CALR
30hepatitis b10.0CCL27
31kawasaki disease10.0S100A12
32duodenitis10.0S100A8
33intrinsic asthma10.0IL5, RNASE3
34pemphigus10.0DSG1
35chronic rhinitis10.0RNASE3
36kimura disease10.0RNASE3, IL5
37folliculitis10.0CCL11
38herpes gestationis10.0RNASE3
39hypersensitivity reaction type ii disease10.0DSG1
40eosinophilic gastroenteritis10.0IL5, CCL11
41uveitis10.0RBP3, CCL11
42churg-strauss syndrome10.0IL5, RNASE3
43helminthiasis10.0RNASE3, IL5
44common cold10.0CCL11, RNASE3
45gastroesophageal reflux disease10.0S100A8
46otitis media10.0CCL11, RNASE3
47primary biliary cirrhosis10.0LBR
48hepatitis10.0CCL27, CCL11
49asthma10.0IL5, RNASE3, EPX
50vasculitis10.0RBP3, S100A12

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Clinical Features for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Onchocerciasis

Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Search CenterWatch for Onchocerciasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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32MalaCards
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MalaCards organs/tissues related to Onchocerciasis:

32
Skin, Eye, Testes, Lymph node, Salivary gland, Breast, T cells

Animal Models for Onchocerciasis or affiliated genes

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Publications for Onchocerciasis

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Sources:
50PubMed
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Articles related to Onchocerciasis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
2
New tools and insights to assist with the molecular identification of Simulium guianense s.l., main Onchocerca volvulus vector within the highland areas of the Amazonia onchocerciasis focus. (24200838)
2013
3
Impact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis: an entomologic evaluation in central Cameroon. (24289520)
2013
4
Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control. (22313631)
2012
5
Morphometric analysis of nodules in human onchocerciasis collected in communities of the southern Chiapas focus, MAcxico. (22662599)
2012
6
Drawing and interpreting data: Children's impressions of onchocerciasis and community-directed treatment with ivermectin (CDTI) in four onchocerciasis endemic countries in Africa. (21637349)
2011
7
Mectizan(Ar) procurement and delivery for onchocerciasis mass drug administration programmes. (20974105)
2011
8
Neglected tropical disease control in post-war Sierra Leone using the Onchocerciasis Control Programme as a platform. (24038179)
2011
9
Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination. (21255577)
2011
10
Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis. (20957145)
2010
11
Factors associated with compliance with community directed treatment with ivermectin for onchocerciasis control in Southwestern Ethiopia. (20525182)
2010
12
Onchocerciasis: elimination is feasible. (19764128)
2009
13
Onchocerciasis (river blindness). Report from the eighteenth InterAmerican Conference on Onchocerciasis, November 2008. (19764129)
2009
14
Seasonal biting pattern of Simulium damnosum s.l and its implications on onchocerciasis treatment with ivermectin. (19469400)
2008
15
African Programme for Onchocerciasis Control--report on task force meeting, July 2008. (18720576)
2008
16
Dracunculiasis, onchocerciasis, schistosomiasis, and trachoma. (17954680)
2008
17
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. (17999080)
2008
18
Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. (18978537)
2008
19
Onchocerciasis in Tigray. (17958630)
2007
20
What is your diagnosis? Onchocerciasis. (17605660)
2007
21
Cytogenetic and PCR-based identification of S. damnosum "Nkusi J" as the anthropophilic blackfly in the Uluguru onchocerciasis focus in Tanzania. (16827707)
2006
22
In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination. (16585501)
2006
23
Preparation and characterization of specific monoclonal antibodies for the detection of adult worm infections in onchocerciasis. (16332194)
2005
24
The problem of trachoma within an onchocerciasis-endemic zone in Kaduna: need for a multilateral approach? (16272051)
2005
25
Review of epidemiological studies searching for a relationship between onchocerciasis and epilepsy. (15084784)
2004
26
The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasis. (15013736)
2004
27
Endemicity of onchocerciasis in some local government areas of Niger state. (15490791)
2004
28
Profile of eye lesions and vision loss: a cross-sectional study in Lusambo, a forest-savanna area hyperendemic for onchocerciasis in the Democratic Republic of Congo. (12535256)
2003
29
Adverse reactions to ivermectin treatment in Simulium neavei-transmitted onchocerciasis. (14740878)
2003
30
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). (11825773)
2002
31
Can ivermectin mass treatments eliminate onchocerciasis in Africa? (12077614)
2002
32
Nematode infections of the eye: toxocariasis, onchocerciasis, diffuse unilateral subacute neuroretinitis, and cysticercosis. (12434484)
2002
33
Immunocompetence may be important in the effectiveness of Mectizan (ivermectin) in the treatment of human onchocerciasis. (12387910)
2002
34
Onchocerciasis in a nonendemic population: clinical and immunologic assessment before treatment and at the time of presumed cure. (11133386)
2001
35
Control of onchocerciasis in Nzerem-Ikpem, Nigeria: baseline prevalence and mass distribution of ivermectin. (11035465)
2000
36
Use of the recombinant Onchocerca volvulus protein Ov20/OvS1 for the immunodiagnostic differentiation between onchocerciasis and mansonelliasis and for the characterization of hyperreactive onchocerciasis (sowda). (11169279)
2000
37
A health club for a community school in south-eastern Nigeria: influence on adult perception of onchocerciasis and compliance with community-based ivermectin therapy. (10747286)
2000
38
The role of NGDOs in disease elimination programmes: the lessons from onchocerciasis control. (11198640)
2000
39
Human onchocerciasis: the essential partnership between research and disease control efforts. (11964814)
2000
40
Effect of repeated ivermectin treatments on ocular onchocerciasis: evaluation after six to eight doses. (10544338)
1999
41
Cross-validation of the rapid epidemiological mapping of onchocerciasis endemicity in Anambra state, Nigeria. (10715700)
1999
42
Patterns of Onchocerca volvulus recombinant antigen recognition in a bovine model of onchocerciasis. (10633922)
1999
43
The causes and profile of visual loss in an onchocerciasis-endemic forest-savanna zone in Nigeria. (10544344)
1999
44
Onchocerciasis. (9643811)
1998
45
The significance of guinea worm infection in the immunological diagnosis of onchocerciasis and bancroftian filariasis. (9861367)
1998
46
A cocktail of recombinant Onchocerca volvulus antigens for serologic diagnosis with the potential to predict the endemicity of onchocerciasis infection. (9886193)
1998
47
Onchocerciasis: The First Decade of Mectizantrade mark Treatment. (17040856)
1998
48
Risk factors for optic nerve disease in communities mesoendemic for savannah onchocerciasis, Kaduna State, Nigeria. (9018306)
1997
49
Dracunculiasis and onchocerciasis. (9335190)
1997
50
Epitopes of the Onchocerca volvulus RAL1 antigen, a member of the calreticulin family of proteins, recognized by sera from patients with onchocerciasis. (7520419)
1994

Genetic Variations for Onchocerciasis

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Expression for genes affiliated with Onchocerciasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Onchocerciasis

Search GEO for disease gene expression data for Onchocerciasis.

Pathways for genes affiliated with Onchocerciasis

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12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Onchocerciasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL5, CCL11, TUBB
29.9CCL11, CCL5, CCL27
3
Hide members
9.8IL5, RNASE3, EPX, CALR, CCL11

Compounds for genes affiliated with Onchocerciasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Onchocerciasis according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1unicap4410.4CCL11, RNASE3, IL5
2anti-histamine4410.4CCL11, CCL5, RNASE3
3sodium cromoglycate4410.3CCL11, EPX, RNASE3, IL5
4lte44410.3CCL11, EPX, RNASE3, IL5
5cetirizine44 28 11 2413.3CCL11, EPX, RNASE3, IL5
65-oxoete4410.3IL5, CCL5, CCL11
7ketotifen44 1111.3CCL11, EPX, RNASE3, IL5
8ltc44410.3CCL11, EPX, RNASE3, IL5
9butyrate4410.3CCL11, RBP3, IL5
10salbutamol44 49 28 11 2414.3IL5, RNASE3, EPX, CCL11
11pgd24410.3IL5, RNASE3, EPX, CCL11
12montelukast44 49 28 1113.3IL5, RNASE3, CCL11
13pranlukast44 28 1112.3CCL11, CCL5, RNASE3, IL5
14Adenosine-2'-5'-Diphosphate1110.3RNASE3, RNASE2
15fluticasone propionate44 49 59 1113.2CCL11, CCL5, RNASE3, IL5
16percoll4410.2IL5, RNASE3, CCL5
17methacholine44 1111.2CCL11, CCL5, RNASE3, IL5
18clarithromycin44 1111.2IL5, S100A8, CCL11
19melatonin44 59 28 11 2414.2EPX, LBR, CALR, TUBB
20salmeterol44 49 28 1113.2IL5, RNASE3, EPX, CCL5, CCL11
21budesonide44 49 1112.2CCL11, CCL5, EPX, RNASE3, IL5
22rantes4410.2CCL11, S100A8, LBR, RNASE3
23tarc4410.1IL5, CCL27, CCL5, CCL11
24p0054410.1CCL5, S100A8, EPX, RNASE3
25con a4410.1IL5, LBR, CALR
26leukotriene b444 59 2412.1IL5, RNASE3, EPX, CCL5, CCL11
27prednisolone44 28 1112.1CCL11, EPX, RNASE3, IL5
28fmlp4410.0CCL11, CCL5, EPX, RNASE3, IL5
29rolipram44 59 2812.0EPX
30ionomycin4410.0CCL11, CCL5, CALR, LBR, IL5
31poly(i-c)4410.0IL5, CCL5, CCL11
32urea44 11 2412.0RNASE3, S100A8, CALR, TUBB
33heparin44 28 11 2412.9CCL11, CCL5, CALR, LBR, EPX, RNASE3
34allergens449.9CCL11, CCL27, S100A8, EPX, RNASE3, IL5
35serine449.9TUBB, CCL5, S100A8, DSG1, EPX
36pge2449.8CCL11, CCL5, CCL27, EPX, RNASE3, IL5
37h2o2449.7TUBB, CCL5, CALR, LBR, EPX, RNASE3
38superoxide44 2410.7CCL11, CALR, S100A8, LBR, MPI, EPX
39creatinine449.7TUBB, CCL5, CCL27, S100A8, EPX, RNASE3
40endotoxin449.6CCL11, CCL5, S100A8, RNASE3
41histamine44 28 2411.6CCL11, CCL5, CALR, S100A8, LBR, EPX
42steroid449.6TUBB, CCL11, CALR, LBR, EPX, RNASE3
43zinc44 2410.5CCL5, CALR, S100A12, S100A8, LBR, RBP3
44nitric oxide44 11 2411.4TUBB, CCL11, CCL5, CALR, S100A8, LBR
45retinoic acid44 2410.4CCL11, CCL5, CALR, S100A8, LBR, RBP3
46cysteine449.3TUBB, CCL5, CALR, S100A8, LBR, EPX
47dexamethasone44 49 28 1112.3CCL11, CCL5, CCL27, CALR, S100A8, LBR
48tyrosine449.2TUBB, CCL11, CCL5, CALR, S100A8, LBR
49lipid449.1TUBB, CCL11, CCL5, CCL27, CALR, S100A8
50calcium44 49 11 2411.9CCL27, CCL5, CCL11, TUBB, CALR, S100A12

GO Terms for genes affiliated with Onchocerciasis

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16Gene Ontology
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Cellular components related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0CCL5, CCL27, CALR, S100A8, RBP3, IL5
2extracellular regionGO:0055768.4IL5, CCL11, CCL5, CCL27, CALR, S100A12

Biological processes related to Onchocerciasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.3CCL11, CCL5
2chronic inflammatory responseGO:00254410.2CCL11, S100A8
3positive regulation of JAK-STAT cascadeGO:04642710.2IL5, CCL5
4RNA catabolic processGO:00640110.1RNASE2, RNASE3
5cellular calcium ion homeostasisGO:00687410.0CALR, CCL5, CCL11
6chemotaxisGO:0069359.9RNASE2, CCL27, CCL5, CCL11
7monocyte chemotaxisGO:0025489.8S100A12, CCL5
8defense response to bacteriumGO:0427429.8S100A12, S100A8, RNASE3
9inflammatory responseGO:0069549.7CCL11, CCL5, S100A12, S100A8, IL5

Molecular functions related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.1RNASE2, RNASE3
2RAGE receptor bindingGO:0507869.9S100A8, S100A12
3chemokine activityGO:0080099.9CCL27, CCL5, CCL11
4ribonuclease activityGO:0045409.8RNASE2, RNASE3

Products for genes affiliated with Onchocerciasis

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Sources for Onchocerciasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet