MCID: ONC002
MIFTS: 50

Onchocerciasis malady

Rare diseases, Infectious diseases categories

Summaries for Onchocerciasis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards: Onchocerciasis, also known as infection by onchocerca volvulus, is related to schistosomiasis and eosinophilia. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR alpha and Allograft rejection. The drug ivermectin and the compounds tele-methylhistamine and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

CDC:4 The page you requested has been moved.

Wikipedia:66 Onchocerciasis (/???k?s?r?sa?.?s?s/ or /???k?s?r?ka?.?s?s/), also known as river blindness and Robles... more...

Aliases & Classifications for Onchocerciasis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
onchocerciasis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

onchocerciasis 9 44 11 46 50 63
infection by onchocerca volvulus 9
onchocerca volvulus infection 9
onchocerciasis, ocular 63
river blindness 44
robles' disease 44
volvulosis 9


External Ids:

Disease Ontology9 DOID:11678
NCIt41 C34861
MeSH36 D009855
ICD9CM28 125.3
ICD10 via Orphanet27 B73
SNOMED-CT59 38539003
SNOMED-CT via Orphanet60 240842000, 38539003
UMLS via Orphanet64 C0029001, C0029002
MESH via Orphanet37 D009855, D015827
ICD1026 B73

Related Diseases for Onchocerciasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis30.7IL5, RNASE3
2eosinophilia30.1IL5, EPX, RNASE3
3helminthiasis29.9IL5, RNASE3
4blindness10.7
5filariasis10.6
6loiasis10.5
7chorioretinitis10.2
8skin disease10.2
9trachoma10.2
10chagas disease10.2
11dracunculiasis10.2
12elephantiasis10.2
13optic nerve disease10.2
14paragonimiasis10.1IL5
15urinary schistosomiasis10.1
16mansonelliasis10.1
17cysticercosis10.1
18malaria10.1
19optic atrophy10.1
20tetanus10.1
21corneal disease10.1
22chronic rhinitis10.1RNASE3
23conjunctivitis10.1RNASE3
24collagenous colitis10.1RNASE3
25pneumonia10.0IL5, EPX
26chronic eosinophilic pneumonia10.0RNASE3, IL5
27giant papillary conjunctivitis10.0IL5, RNASE3
28proctitis10.0EPX, RNASE3
29intrinsic asthma10.0RNASE3, IL5
30allergic conjunctivitis10.0RNASE3, IL5
31kimura disease10.0RNASE3, IL5
32churg-strauss syndrome10.0RNASE3, IL5
33eosinophilic pneumonia10.0RNASE3, IL5
34keratoconjunctivitis10.0RNASE3, IL5
35vernal keratoconjunctivitis10.0RNASE3, IL5
36angioedema10.0RNASE3, IL5
37sinusitis10.0IL5, RNASE3
38bronchitis10.0IL5, RNASE3
39respiratory failure10.0EPX, RNASE3
40bronchiolitis10.0IL5, RNASE3
41bullous pemphigoid10.0IL5, RNASE3
42pulmonary eosinophilia10.0EPX, IL5, RNASE3
43food allergy10.0RNASE3, EPX, IL5
44hypereosinophilic syndrome10.0RNASE3, EPX, IL5
45rhinitis10.0EPX, IL5, RNASE3
46atopy10.0IL5, EPX, RNASE3
47allergic rhinitis10.0RNASE3, EPX, IL5
48allergic asthma10.0IL5, EPX, RNASE3
49atopic dermatitis10.0IL5, RNASE3, EPX
50dilated cardiomyopathy10.0CALR, TUBB

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Symptoms for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Onchocerciasis

Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Search CenterWatch for Onchocerciasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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34MalaCards
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MalaCards organs/tissues related to Onchocerciasis:

34
Skin, Eye, Testes, Lymph node, Breast, T cells, Salivary gland

Animal Models for Onchocerciasis or affiliated genes

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Publications for Onchocerciasis

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Sources:
53PubMed
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Articles related to Onchocerciasis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
2
Rapid epidemiological assessment of onchocerciasis in a tropical semi-urban community, enugu state, Nigeria. (23682272)
2013
3
African Programme for Onchocerciasis Control: meeting of National Onchocerciasis Task Forces, September 2013. (24367839)
2013
4
Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal. (23029586)
2012
5
Zoonotic onchocerciasis in Hiroshima, Japan, and molecular analysis of a paraffin section of the agent for a reliable identification. (21678795)
2011
6
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
7
Polymerase chain reaction pool screening used to compare prevalence of infective black flies in two onchocerciasis foci in northern Sudan. (21540385)
2011
8
Report from the 2009 Inter-American Conference on Onchocerciasis: progress towards eliminating river blindness in the Region of the Americas. (20707042)
2010
9
Anticoagulant activity in salivary gland homogenates of Thyrsopelma guianense (Diptera: Simuliidae), the primary vector of onchocerciasis in the Brazilian Amazon. (20428677)
2010
10
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
11
Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis. (18419585)
2008
12
Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern Nigeria. (18186977)
2008
13
After a decade of annual dose mass ivermectin treatment in Cameroon and Uganda, onchocerciasis transmission continues. (18631308)
2008
14
Infective larvae of five Onchocerca species from experimentally infected Simulium species in an area of zoonotic onchocerciasis in Japan. (18642503)
2008
15
Onchocerciasis (river blindness). Report from the sixteenth InterAmerican Conference on Onchocerciasis, Antigua Guatemala, Guatemala. (17763565)
2007
16
Molecular systematics of Simulium squamosum, the vector in the Kinsuka onchocerciasis focus (Kinshasa, Democratic Republic of Congo). (17362602)
2007
17
Cytogenetic and PCR-based identification of S. damnosum &quot;Nkusi J&quot; as the anthropophilic blackfly in the Uluguru onchocerciasis focus in Tanzania. (16827707)
2006
18
Consequences of vector behavior in epidemiology of onchocerciasis on the Firestone Rubber Plantation in Liberia. (16687689)
2006
19
Canine ocular onchocerciasis in the United States: two new cases and a review of the literature. (15644101)
2005
20
Report of a Scientific Working Group on Serious Adverse Events following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas. (14975059)
2004
21
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
22
Onchocerciasis (river blindness). Report from the thirteenth InterAmerican Conference on Onchocerciasis, Cartagena de Indias, Colombia. (15460014)
2004
23
Onchocerciasis. (15035021)
2003
24
Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis. (14584385)
2003
25
Profile of eye lesions and vision loss: a cross-sectional study in Lusambo, a forest-savanna area hyperendemic for onchocerciasis in the Democratic Republic of Congo. (12535256)
2003
26
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). (11825773)
2002
27
Rapid epidemiological mapping of onchocerciasis (REMO): its application by the African Programme for Onchocerciasis Control (APOC). (12081248)
2002
28
Subconjunctival zoonotic onchocerciasis in man: aberrant infection with Onchocerca lupi? (12194710)
2002
29
Excess mortality associated with blindness in the onchocerciasis focus of the Mbam Valley, Cameroon. (12080979)
2002
30
Validity of nodule palpation in a Simulium neavei-transmitted onchocerciasis area in Uganda. (12363057)
2002
31
Human onchocerciasis in the Amazonian area of southern Venezuela: spatial and temporal variations in biting and parity rates of black fly (Diptera: Simuliidae) vectors. (11476332)
2001
32
Community-based ivermectin therapy for onchocerciasis: comparison of three methods of dose assessment. (11561701)
2001
33
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
34
A rapid-format antibody card test for diagnosis of onchocerciasis. (11069258)
2000
35
Dispersal range of Simulium neavei in an onchocerciasis focus of western Uganda. (10759318)
2000
36
Clinical and parasitological aspects of itching caused by onchocerciasis in Morogoro, Tanzania. (11214098)
2000
37
Onchocerca-Simulium complexes in Venezuela: can human onchocerciasis spread outside its present endemic areas? (10726276)
2000
38
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
39
Effect of repeated ivermectin treatments on ocular onchocerciasis: evaluation after six to eight doses. (10544338)
1999
40
Onchocerciasis. (9643811)
1998
41
Human onchocerciasis: current assessment of the disease burden in Nigeria by rapid epidemiological mapping. (9861272)
1998
42
Evaluation of community compliance with annual ivermectin treatment of onchocerciasis in Patigi, Nigeria. (9745842)
1998
43
IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis. (9605145)
1998
44
Onchocerciasis and reproductive health in Ecuador. (9231206)
1997
45
Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. (9357488)
1997
46
Gynaecomastia in onchocerciasis. (9142073)
1997
47
Reduction in incidence of optic nerve disease with annual ivermectin to control onchocerciasis. (8093742)
1993
48
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
49
Experimental ocular onchocerciasis in cynomolgus monkeys. III. Roles of IgG and IgE antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. (3175465)
1988
50
Onchocerciasis and optic atrophy in the Savannah area of Ghana. (3451406)
1987

Variations for Onchocerciasis

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Expression for genes affiliated with Onchocerciasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Onchocerciasis

Search GEO for disease gene expression data for Onchocerciasis.

Pathways for genes affiliated with Onchocerciasis

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Sources:
51PathCards, 13EMD Millipore, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Onchocerciasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL5, TUBB
2
Show member pathways
8.1CALR, IL5, EPX, RNASE3

Compounds for genes affiliated with Onchocerciasis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Onchocerciasis according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tele-methylhistamine469.8EPX, RNASE3
2mometasone furoate46 6210.7IL5, RNASE3
3unicap469.7RNASE3, IL5
4levocabastine46 30 1211.7RNASE3, IL5
5sephadex469.7RNASE3, EPX
6beclomethasone dipropionate469.7RNASE3, IL5
7toluene diisocyanate469.7RNASE3, IL5
8nedocromil sodium469.6IL5, RNASE3
9pranlukast46 30 1211.6RNASE3, IL5
10praziquantel46 1210.6RNASE3, IL5
11azelastine46 1210.6RNASE3, IL5
12ltd4469.5RNASE3, IL5
13montelukast46 52 30 1212.4RNASE3, IL5
14percoll469.4RNASE3, IL5
15p005469.4EPX, RNASE3
16sodium cromoglycate469.3EPX, IL5, RNASE3
17lte4469.3EPX, IL5, RNASE3
18cetirizine46 30 25 1212.3EPX, IL5, RNASE3
19salmeterol46 52 30 1212.3IL5, EPX, RNASE3
20ketotifen46 1210.3IL5, EPX, RNASE3
21ltc4469.3RNASE3, EPX, IL5
22budesonide46 52 1211.3IL5, EPX, RNASE3
23salbutamol46 52 30 25 1213.3EPX, RNASE3, IL5
24pgd2469.3RNASE3, IL5, EPX
25allergens469.3RNASE3, EPX, IL5
26theophylline46 30 25 1212.3RNASE3, EPX, IL5
27leukotriene b446 62 2511.3IL5, RNASE3, EPX
28gliadin469.3RNASE3, CALR
29prednisolone46 30 1211.3IL5, RNASE3, EPX
30butyrate469.2RBP3, EPX, IL5
31formaldehyde46 2510.2RNASE3, EPX, TUBB
32fmlp469.2RNASE3, EPX, IL5
33melatonin46 30 62 25 1213.1TUBB, CALR, EPX
34fluticasone propionate46 52 62 1212.0IL5, RNASE3
35con a469.0IL5, CALR
36chloride469.0CALR, TUBB, EPX
37urea46 25 1210.9CALR, RNASE3, TUBB
38glutamine468.6RBP3, CALR, IL5, TUBB
39histamine46 30 2510.5CALR, IL5, RNASE3, EPX
40lactate468.5CALR, RNASE3, TUBB, EPX
41heparin46 30 25 1211.5CALR, RNASE3, IL5, EPX
42steroid468.4EPX, TUBB, RNASE3, CALR
43dexamethasone46 52 30 1211.4CALR, IL5, EPX, RNASE3
44adenylate468.4CALR, TUBB, RNASE3, IL5
45cysteine468.3EPX, CALR, IL5, TUBB
46retinoic acid46 259.3RBP3, IL5, CALR, RNASE3
47nitric oxide46 25 1210.1TUBB, RNASE3, EPX, RBP3, CALR
48lipid468.1TUBB, RNASE3, CALR, EPX
49h2o2468.0IL5, CALR, EPX, TUBB, RNASE3
50tyrosine467.9EPX, CALR, RNASE3, IL5, TUBB

GO Terms for genes affiliated with Onchocerciasis

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17Gene Ontology
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Cellular components related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1RBP3, CALR, IL5, RNASE3

Products for genes affiliated with Onchocerciasis

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Sources for Onchocerciasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet