MCID: ONC002
MIFTS: 52

Onchocerciasis malady

Rare diseases, Infectious diseases categories
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Summaries for Onchocerciasis

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Disease Ontology:8 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards based summary: Onchocerciasis, also known as infection by onchocerca volvulus, is related to schistosomiasis and helminthiasis. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR alpha and Allograft rejection. The drug ivermectin and the compounds tele-methylhistamine and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

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Wikipedia:65 Onchocerciasis (/???k?s?r?sa?.?s?s/ or /???k?s?r?ka?.?s?s/), also known as river blindness and Robles... more...

Aliases & Classifications for Onchocerciasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Onchocerciasis, Aliases & Descriptions:

Name: Onchocerciasis 8 42 10 44 48 62
Infection by Onchocerca Volvulus 8 62
Onchocerca Volvulus Infection 8 62
Onchocerciasis, Ocular 62
 
River Blindness 42
Robles' Disease 42
Volvulosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
onchocerciasis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:11678
ICD9CM27 125.3
MeSH34 D009855
NCIt39 C34861
SNOMED-CT57 38539003
MESH via Orphanet35 D009855, D015827
ICD10 via Orphanet26 B73
UMLS via Orphanet63 C0029001, C0029002
ICD1025 B73

Related Diseases for Onchocerciasis

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Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Symptoms for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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MalaCards organs/tissues related to Onchocerciasis:

32
Skin, Eye, Testes, Neutrophil, Lymph node, Salivary gland, Breast, T cells

Animal Models for Onchocerciasis or affiliated genes

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Publications for Onchocerciasis

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Articles related to Onchocerciasis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
2
African Programme for Onchocerciasis Control: meeting of National Onchocerciasis Task Forces, September 2013. (24367839)
2013
3
Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal. (23029586)
2012
4
Zoonotic onchocerciasis in Hiroshima, Japan, and molecular analysis of a paraffin section of the agent for a reliable identification. (21678795)
2011
5
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
6
Polymerase chain reaction pool screening used to compare prevalence of infective black flies in two onchocerciasis foci in northern Sudan. (21540385)
2011
7
Report from the 2009 Inter-American Conference on Onchocerciasis: progress towards eliminating river blindness in the Region of the Americas. (20707042)
2010
8
Anticoagulant activity in salivary gland homogenates of Thyrsopelma guianense (Diptera: Simuliidae), the primary vector of onchocerciasis in the Brazilian Amazon. (20428677)
2010
9
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
10
Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasis. (19008151)
2009
11
Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis. (18419585)
2008
12
Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern Nigeria. (18186977)
2008
13
After a decade of annual dose mass ivermectin treatment in Cameroon and Uganda, onchocerciasis transmission continues. (18631308)
2008
14
Infective larvae of five Onchocerca species from experimentally infected Simulium species in an area of zoonotic onchocerciasis in Japan. (18642503)
2008
15
Molecular systematics of Simulium squamosum, the vector in the Kinsuka onchocerciasis focus (Kinshasa, Democratic Republic of Congo). (17362602)
2007
16
Cytogenetic and PCR-based identification of S. damnosum &quot;Nkusi J&quot; as the anthropophilic blackfly in the Uluguru onchocerciasis focus in Tanzania. (16827707)
2006
17
Consequences of vector behavior in epidemiology of onchocerciasis on the Firestone Rubber Plantation in Liberia. (16687689)
2006
18
Canine ocular onchocerciasis in the United States: two new cases and a review of the literature. (15644101)
2005
19
Report of a Scientific Working Group on Serious Adverse Events following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas. (14975059)
2004
20
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
21
Onchocerciasis. (15035021)
2003
22
Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis. (14584385)
2003
23
Profile of eye lesions and vision loss: a cross-sectional study in Lusambo, a forest-savanna area hyperendemic for onchocerciasis in the Democratic Republic of Congo. (12535256)
2003
24
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). (11825773)
2002
25
Rapid epidemiological mapping of onchocerciasis (REMO): its application by the African Programme for Onchocerciasis Control (APOC). (12081248)
2002
26
Subconjunctival zoonotic onchocerciasis in man: aberrant infection with Onchocerca lupi? (12194710)
2002
27
Excess mortality associated with blindness in the onchocerciasis focus of the Mbam Valley, Cameroon. (12080979)
2002
28
Validity of nodule palpation in a Simulium neavei-transmitted onchocerciasis area in Uganda. (12363057)
2002
29
Human onchocerciasis in the Amazonian area of southern Venezuela: spatial and temporal variations in biting and parity rates of black fly (Diptera: Simuliidae) vectors. (11476332)
2001
30
Community-based ivermectin therapy for onchocerciasis: comparison of three methods of dose assessment. (11561701)
2001
31
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
32
A rapid-format antibody card test for diagnosis of onchocerciasis. (11069258)
2000
33
Dispersal range of Simulium neavei in an onchocerciasis focus of western Uganda. (10759318)
2000
34
Clinical and parasitological aspects of itching caused by onchocerciasis in Morogoro, Tanzania. (11214098)
2000
35
The prevalence of onchocerciasis and other parasitic infestations on an oil palm plantation in Ghana. (10902470)
2000
36
Onchocerca-Simulium complexes in Venezuela: can human onchocerciasis spread outside its present endemic areas? (10726276)
2000
37
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
38
Effect of repeated ivermectin treatments on ocular onchocerciasis: evaluation after six to eight doses. (10544338)
1999
39
Onchocerciasis. (9643811)
1998
40
Human onchocerciasis: current assessment of the disease burden in Nigeria by rapid epidemiological mapping. (9861272)
1998
41
Evaluation of community compliance with annual ivermectin treatment of onchocerciasis in Patigi, Nigeria. (9745842)
1998
42
IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis. (9605145)
1998
43
Onchocerciasis and reproductive health in Ecuador. (9231206)
1997
44
Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. (9357488)
1997
45
Gynaecomastia in onchocerciasis. (9142073)
1997
46
Reduced prevalence of onchocerciasis in Uganda following either deforestation or vector control with DDT. (9337013)
1997
47
Reduction in incidence of optic nerve disease with annual ivermectin to control onchocerciasis. (8093742)
1993
48
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
49
Experimental ocular onchocerciasis in cynomolgus monkeys. III. Roles of IgG and IgE antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. (3175465)
1988
50
Onchocerciasis and optic atrophy in the Savannah area of Ghana. (3451406)
1987

Variations for Onchocerciasis

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Expression for genes affiliated with Onchocerciasis

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Expression patterns in normal tissues for genes affiliated with Onchocerciasis

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Pathways for genes affiliated with Onchocerciasis

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Pathways related to Onchocerciasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL5, TUBB
2
Show member pathways
8.1CALR, IL5, EPX, RNASE3

Compounds for genes affiliated with Onchocerciasis

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Compounds related to Onchocerciasis according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tele-methylhistamine449.8RNASE3, EPX
2mometasone furoate44 6110.7RNASE3, IL5
3unicap449.7RNASE3, IL5
4levocabastine44 28 1111.7RNASE3, IL5
5beclomethasone dipropionate449.7RNASE3, IL5
6sephadex449.7EPX, RNASE3
7toluene diisocyanate449.7IL5, RNASE3
8nedocromil sodium449.6RNASE3, IL5
9pranlukast44 28 1111.6IL5, RNASE3
10praziquantel44 1110.6IL5, RNASE3
11azelastine44 1110.6RNASE3, IL5
12ltd4449.5IL5, RNASE3
13montelukast44 50 28 1112.4RNASE3, IL5
14percoll449.4IL5, RNASE3
15p005449.4EPX, RNASE3
16lte4449.3IL5, EPX, RNASE3
17sodium cromoglycate449.3IL5, EPX, RNASE3
18cetirizine44 28 24 1112.3RNASE3, EPX, IL5
19ketotifen44 1110.3IL5, EPX, RNASE3
20salmeterol44 50 28 1112.3IL5, EPX, RNASE3
21ltc4449.3IL5, EPX, RNASE3
22budesonide44 50 1111.3RNASE3, EPX, IL5
23salbutamol44 50 28 24 1113.3IL5, EPX, RNASE3
24pgd2449.3IL5, EPX, RNASE3
25allergens449.3IL5, EPX, RNASE3
26theophylline44 28 24 1112.3RNASE3, EPX, IL5
27gliadin449.3RNASE3, CALR
28leukotriene b444 61 2411.3RNASE3, EPX, IL5
29prednisolone44 28 1111.3IL5, EPX, RNASE3
30butyrate449.2RBP3, IL5, EPX
31formaldehyde44 2410.2EPX, RNASE3, TUBB
32fmlp449.2IL5, EPX, RNASE3
33melatonin44 28 61 24 1113.1TUBB, EPX, CALR
34fluticasone propionate44 50 61 1112.0IL5, RNASE3
35con a449.0CALR, IL5
36chloride449.0TUBB, EPX, CALR
37urea44 24 1110.9CALR, RNASE3, TUBB
38glutamine448.6TUBB, IL5, CALR, RBP3
39histamine44 28 2410.5RNASE3, EPX, IL5, CALR
40lactate448.5CALR, EPX, RNASE3, TUBB
41heparin44 28 24 1111.5CALR, IL5, EPX, RNASE3
42steroid448.4TUBB, RNASE3, EPX, CALR
43dexamethasone44 50 28 1111.4RNASE3, EPX, IL5, CALR
44adenylate448.4CALR, IL5, RNASE3, TUBB
45cysteine448.3TUBB, EPX, IL5, CALR
46retinoic acid44 249.3RNASE3, IL5, CALR, RBP3
47nitric oxide44 24 1110.1TUBB, RNASE3, EPX, CALR, RBP3
48lipid448.1TUBB, RNASE3, EPX, CALR
49h2o2448.0TUBB, RNASE3, EPX, IL5, CALR
50tyrosine447.9CALR, IL5, EPX, RNASE3, TUBB

GO Terms for genes affiliated with Onchocerciasis

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Cellular components related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1RBP3, CALR, IL5, RNASE3

Products for genes affiliated with Onchocerciasis

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Sources for Onchocerciasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet