MCID: ONC002
MIFTS: 50

Onchocerciasis malady

Infectious category

Summaries for Onchocerciasis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards: Onchocerciasis, also known as river blindness, is related to helminthiasis and tuberculosis. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR-alpha and Chemokine receptors bind chemokines. The drug ivermectin and the compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and small intestine.

CDC:3 The page you requested has been moved.

Wikipedia:64 Onchocerciasis (/ˈɒŋkɵsɜrˈsaɪ.əsɨs/ or /ˈɒŋkɵsɜrˈkaɪ.əsɨs/), also known as river... more...

Aliases & Classifications for Onchocerciasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
onchocerciasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

onchocerciasis 8 43 10 45 49 61
river blindness 43 49
infection by onchocerca volvulus 8
onchocerca volvulus infection 8
onchocerciasis, ocular 61
robles' disease 43
volvulosis 8


External Ids:

Disease Ontology8 DOID:11678
ICD9CM27 125.3
NCIt40 C34861
MeSH35 D009855
ICD10 via Orphanet26 B73
SNOMED-CT57 38539003
SNOMED-CT via Orphanet58 240842000, 38539003
UMLS via Orphanet62 C0029001, C0029002
MESH via Orphanet36 D009855, D015827
ICD1025 B73

Related Diseases for Onchocerciasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1helminthiasis29.9RNASE3, IL5
2tuberculosis29.9EPX, LBR, CALR
3blindness10.7
4loiasis10.5
5trachoma10.2
6chagas disease10.2
7dracunculiasis10.2
8urinary schistosomiasis10.1
9cysticercosis10.1
10intestinal schistosomiasis10.1
11mansonelliasis10.1
12tetanus10.1
13corneal disease10.1
14diabetes mellitus10.0CALR
15bronchitis10.0RNASE3
16paragonimiasis10.0IL5
17strongyloidiasis10.0IL5
18lupus erythematosus10.0CALR
19celiac disease10.0CALR
20hepatitis b10.0CCL27
21kawasaki disease10.0S100A12
22duodenitis10.0S100A8
23intrinsic asthma10.0IL5, RNASE3
24pemphigus10.0DSG1
25chronic rhinitis10.0RNASE3
26kimura disease10.0RNASE3, IL5
27malaria10.0CCL5
28folliculitis10.0CCL11
29herpes gestationis10.0RNASE3
30hypersensitivity reaction type ii disease10.0DSG1
31eosinophilic gastroenteritis10.0IL5, CCL11
32uveitis10.0RBP3, CCL11
33schistosomiasis10.0IL5, RNASE3
34churg-strauss syndrome10.0IL5, RNASE3
35common cold10.0CCL11, RNASE3
36gastroesophageal reflux disease10.0S100A8
37otitis media10.0CCL11, RNASE3
38primary biliary cirrhosis10.0LBR
39hepatitis10.0CCL27, CCL11
40asthma10.0IL5, RNASE3, EPX
41vasculitis10.0RBP3, S100A12
42leishmaniasis10.0MPI, IL5
43pemphigus vulgaris10.0DSG1, CCL11
44measles10.0LBR
45chronic eosinophilic pneumonia10.0CCL11, RNASE3, IL5
46giant papillary conjunctivitis10.0IL5, RNASE3, CCL11
47cervical cancer10.0CALR, TUBB
48atopic dermatitis10.0CCL11, CCL27, RNASE3
49allergic conjunctivitis10.0IL5, RNASE3, CCL11
50neuritis10.0CCL5

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Clinical Features for Onchocerciasis

Drugs & Therapeutics for Onchocerciasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Onchocerciasis

Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Search CenterWatch for Onchocerciasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Onchocerciasis

Anatomical Context for Onchocerciasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Onchocerciasis:

33
Skin, Lymph node, Small intestine, Salivary gland, Breast, T cells

Animal Models for Onchocerciasis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Onchocerciasis

Sources:
51PubMed
See all sources

Articles related to Onchocerciasis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador. (22117902)
2012
2
Hyperendemicity of onchocerciasis in Ovia Northeast Local Government Area, Edo State, Nigeria. (21413580)
2010
3
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. (20142509)
2010
4
Perceptions on onchocerciasis and ivermectin treatment in rural communities in Uganda: implications for long-term compliance. (24036561)
2009
5
Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal. (19621091)
2009
6
Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern Nigeria. (18186977)
2008
7
The African Programme for Onchocerciasis Control (APOC). (18718149)
2008
8
Elimination of the Djodji form of the blackfly Simulium sanctipauli sensu stricto as a result of larviciding by the WHO Onchocerciasis Control Programme in West Africa. (18498618)
2008
9
The NGDO Co-ordination Group for Onchocerciasis Control. (18718153)
2008
10
Diagnostic value of nodule palpation in onchocerciasis. (18082234)
2008
11
Community directed interventions for malaria, tuberculosis and vitamin A in onchocerciasis endemic districts of Tanzania. (19402585)
2008
12
The significance of some observations on African ocular onchocerciasis described by Jean Hissette (1888-1965). (18546927)
2008
13
Molecular systematics of Simulium squamosum, the vector in the Kinsuka onchocerciasis focus (Kinshasa, Democratic Republic of Congo). (17362602)
2007
14
Status of forest onchocerciasis in the Lower Cross River Basin, Nigeria: change in clinical and parasitological indices after 6 years of ivermectin intervention. (17241647)
2007
15
The Concept Paper on the Helminth Drug Initiative. Onchocerciasis/lymphatic filariasis and schistosomiasis: opportunities and challenges for the discovery of new drugs/diagnostics. (23489030)
2007
16
Susceptibility of Simulium damnosum complex larvae to temephos in the Tukuyu onchocerciasis focus, southwest Tanzania. (17547096)
2007
17
The role of Wolbachia bacteria in the pathogenesis of onchocerciasis and prospects for control of the disease. (17642180)
2007
18
Performance of predictors: evaluating sustainability in community-directed treatment projects of the African programme for onchocerciasis control. (17383061)
2007
19
Analysis of genetic variation in ribosomal DNA internal transcribed spacer and the NADH dehydrogenase subunit 4 mitochondrial genes of the onchocerciasis vector Simulium ochraceum. (16892627)
2006
20
Onchocerciasis (21290648)
2006
21
Adverse reactions to the ivermectin treatment of onchocerciasis patients: does infection with the human immunodeficiency virus play a role? (15949187)
2005
22
Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). (16170768)
2005
23
Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis. (14584385)
2003
24
Onchocerciasis (river blindness). (12901252)
2003
25
Case definitions. Onchocerciasis (river blindness). (15112623)
2003
26
Clinical picture and outcome of Serious Adverse Events in the treatment of Onchocerciasis. (14975063)
2003
27
Final report of the Conference on the eradicability of Onchocerciasis. (12605722)
2003
28
Excess mortality associated with blindness in the onchocerciasis focus of the Mbam Valley, Cameroon. (12080979)
2002
29
Validity of nodule palpation in a Simulium neavei-transmitted onchocerciasis area in Uganda. (12363057)
2002
30
Future directions for vaccine-related onchocerciasis research. (12036727)
2002
31
Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis). (12443893)
2002
32
Antibiotics for the treatment of onchocerciasis and other filarial infections. (12090719)
2002
33
Eye lesions and onchocerciasis in a rural farm settlement in Delta state, Nigeria. (12118455)
2002
34
Onchocerciasis-associated morbidity: hypothesis. (12474485)
2002
35
Eliminating onchocerciasis as a public health problem: the beginning of the end. (12140199)
2002
36
Eye lesions and onchocerciasis in a rural farm settlement in Delta State, Nigeria. (12206038)
2001
37
Combined benefits of annual mass treatment with ivermectin and cattle zooprophylaxis on the severity of human onchocerciasis in northern Cameroon. (11555439)
2001
38
The prevalence of onchocerciasis and other parasitic infestations on an oil palm plantation in Ghana. (10902470)
2000
39
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
40
Influence of health education on community participation in rapid assessment of onchocerciasis prior to distribution of ivermectin. (10750518)
1999
41
Onchocerciasis. (10401187)
1999
42
Onchocerciasis: a Latin American perspective. (9861284)
1998
43
Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. (9357488)
1997
44
Patterns of epidemiology and control of onchocerciasis in west Africa. (9192715)
1997
45
The potential for dispersal of onchocerciasis in Ecuador in relation to the distribution of the vector Simulium exiguum (Diptera:Simuliidae). (9332581)
1997
46
Comparison of two sample survey methods for hyperendemic onchocerciasis and a new focus in Dakka, Nigeria. (9458989)
1997
47
Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (8619876)
1996
48
Analysis of aqueous humour in ocular onchocerciasis. (2036808)
1991
49
Experimental ocular onchocerciasis in cynomolgus monkeys. II. Chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. (3182199)
1988
50
Elephantiasis of the lower extremities in Ethiopia: failure to implicate onchocerciasis as an etiologic agent by skin-snip and fluorescent antibody staining techniques. (4589500)
1974

Genetic Variations for Onchocerciasis

Expression for genes affiliated with Onchocerciasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Onchocerciasis

Search GEO for disease gene expression data for Onchocerciasis.

Pathways for genes affiliated with Onchocerciasis

Sources:
12EMD Millipore, 54Reactome, 30KEGG
See all sources

Pathways related to Onchocerciasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL5, CCL11, TUBB
29.9CCL11, CCL5, CCL27
3
Hide members
9.8IL5, RNASE3, EPX, CALR, CCL11

Compounds for genes affiliated with Onchocerciasis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Onchocerciasis according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1unicap4510.4CCL11, RNASE3, IL5
2anti-histamine4510.4CCL11, CCL5, RNASE3
3sodium cromoglycate4510.3CCL11, EPX, RNASE3, IL5
4lte44510.3CCL11, EPX, RNASE3, IL5
5cetirizine45 29 11 2413.3CCL11, EPX, RNASE3, IL5
65-oxoete4510.3IL5, CCL5, CCL11
7ketotifen45 1111.3CCL11, EPX, RNASE3, IL5
8ltc44510.3CCL11, EPX, RNASE3, IL5
9butyrate4510.3CCL11, RBP3, IL5
10salbutamol45 50 29 11 2414.3IL5, RNASE3, EPX, CCL11
11pgd24510.3IL5, RNASE3, EPX, CCL11
12montelukast45 50 29 1113.3IL5, RNASE3, CCL11
13pranlukast45 29 1112.3CCL11, CCL5, RNASE3, IL5
14Adenosine-2'-5'-Diphosphate1110.3RNASE3, RNASE2
15fluticasone propionate45 50 60 1113.2CCL11, CCL5, RNASE3, IL5
16percoll4510.2IL5, RNASE3, CCL5
17methacholine45 1111.2CCL11, CCL5, RNASE3, IL5
18clarithromycin45 1111.2IL5, S100A8, CCL11
19melatonin45 60 29 11 2414.2EPX, LBR, CALR, TUBB
20salmeterol45 50 29 1113.2IL5, RNASE3, EPX, CCL5, CCL11
21budesonide45 50 1112.2CCL11, CCL5, EPX, RNASE3, IL5
22rantes4510.2CCL11, S100A8, LBR, RNASE3
23tarc4510.1IL5, CCL27, CCL5, CCL11
24p0054510.1CCL5, S100A8, EPX, RNASE3
25con a4510.1IL5, LBR, CALR
26leukotriene b445 60 2412.1IL5, RNASE3, EPX, CCL5, CCL11
27prednisolone45 29 1112.1CCL11, EPX, RNASE3, IL5
28fmlp4510.0CCL11, CCL5, EPX, RNASE3, IL5
29rolipram45 60 2912.0EPX
30ionomycin4510.0CCL11, CCL5, CALR, LBR, IL5
31poly(i-c)4510.0IL5, CCL5, CCL11
32urea45 11 2412.0RNASE3, S100A8, CALR, TUBB
33heparin45 29 11 2412.9CCL11, CCL5, CALR, LBR, EPX, RNASE3
34allergens459.9CCL11, CCL27, S100A8, EPX, RNASE3, IL5
35serine459.9TUBB, CCL5, S100A8, DSG1, EPX
36pge2459.8CCL11, CCL5, CCL27, EPX, RNASE3, IL5
37h2o2459.7TUBB, CCL5, CALR, LBR, EPX, RNASE3
38superoxide45 2410.7CCL11, CALR, S100A8, LBR, MPI, EPX
39creatinine459.7TUBB, CCL5, CCL27, S100A8, EPX, RNASE3
40endotoxin459.6CCL11, CCL5, S100A8, RNASE3
41histamine45 29 2411.6CCL11, CCL5, CALR, S100A8, LBR, EPX
42steroid459.6TUBB, CCL11, CALR, LBR, EPX, RNASE3
43zinc45 2410.5CCL5, CALR, S100A12, S100A8, LBR, RBP3
44nitric oxide45 11 2411.4TUBB, CCL11, CCL5, CALR, S100A8, LBR
45retinoic acid45 2410.4CCL11, CCL5, CALR, S100A8, LBR, RBP3
46cysteine459.3TUBB, CCL5, CALR, S100A8, LBR, EPX
47dexamethasone45 50 29 1112.3CCL11, CCL5, CCL27, CALR, S100A8, LBR
48tyrosine459.2TUBB, CCL11, CCL5, CALR, S100A8, LBR
49lipid459.1TUBB, CCL11, CCL5, CCL27, CALR, S100A8
50calcium45 50 11 2411.9CCL27, CCL5, CCL11, TUBB, CALR, S100A12

GO Terms for genes affiliated with Onchocerciasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0CCL5, CCL27, CALR, S100A8, RBP3, IL5
2extracellular regionGO:0055768.4IL5, CCL11, CCL5, CCL27, CALR, S100A12

Biological processes related to Onchocerciasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.3CCL11, CCL5
2chronic inflammatory responseGO:00254410.2CCL11, S100A8
3positive regulation of JAK-STAT cascadeGO:04642710.2IL5, CCL5
4RNA catabolic processGO:00640110.1RNASE2, RNASE3
5cellular calcium ion homeostasisGO:00687410.0CALR, CCL5, CCL11
6chemotaxisGO:0069359.9RNASE2, CCL27, CCL5, CCL11
7monocyte chemotaxisGO:0025489.8S100A12, CCL5
8defense response to bacteriumGO:0427429.8S100A12, S100A8, RNASE3
9inflammatory responseGO:0069549.7CCL11, CCL5, S100A12, S100A8, IL5

Molecular functions related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.1RNASE2, RNASE3
2RAGE receptor bindingGO:0507869.9S100A8, S100A12
3chemokine activityGO:0080099.9CCL27, CCL5, CCL11
4ribonuclease activityGO:0045409.8RNASE2, RNASE3

Products for genes affiliated with Onchocerciasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Onchocerciasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet