MCID: ONC002
MIFTS: 43

Onchocerciasis malady

Rare diseases, Infectious diseases, Bone diseases categories

Aliases & Classifications for Onchocerciasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 2CDC, 61UMLS, 39NCIt, 27ICD9CM, 33MeSH, 56SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Onchocerciasis:

Name: Onchocerciasis 8 42 10 44 48 2 61
River Blindness 42 2
Infection by Onchocerca Volvulus 8
Onchocerca Volvulus Infection 8
 
Onchocerciasis, Ocular 61
Robles' Disease 42
Volvulosis 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
onchocerciasis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology8 DOID:11678
NCIt39 C34861
ICD9CM27 125.3
MeSH33 D009855
Orphanet48 2737
SNOMED-CT56 38539003
MESH via Orphanet34 D009855, D015827
ICD10 via Orphanet26 B73
UMLS via Orphanet62 C0029001, C0029002
ICD1025 B73

Summaries for Onchocerciasis

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Disease Ontology:8 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards based summary: Onchocerciasis, also known as river blindness, is related to schistosomiasis and eosinophilia. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR alpha and Allograft rejection. The drug ivermectin and the compounds tele-methylhistamine and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Wikipedia:64 Onchocerciasis (/???k?s?r?sa?.?s?s/ or /???k?s?r?ka?.?s?s/), also known as river blindness and Robles... more...

Related Diseases for Onchocerciasis

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Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Symptoms for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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MalaCards organs/tissues related to Onchocerciasis:

31
Skin, Eye, Testes, Neutrophil, Lymph node, T cells, Salivary gland, Breast

Animal Models for Onchocerciasis or affiliated genes

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Publications for Onchocerciasis

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Articles related to Onchocerciasis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Conventional parasitology and DNA-based diagnostic methods for onchocerciasis elimination programmes. (25818324)
2015
2
Zoonotic onchocerciasis. (25677336)
2015
3
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
4
Rapid epidemiological assessment of onchocerciasis in a tropical semi-urban community, enugu state, Nigeria. (23682272)
2013
5
Zoonotic onchocerciasis in Hiroshima, Japan, and molecular analysis of a paraffin section of the agent for a reliable identification. (21678795)
2011
6
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
7
Polymerase chain reaction pool screening used to compare prevalence of infective black flies in two onchocerciasis foci in northern Sudan. (21540385)
2011
8
Report from the 2009 Inter-American Conference on Onchocerciasis: progress towards eliminating river blindness in the Region of the Americas. (20707042)
2010
9
Anticoagulant activity in salivary gland homogenates of Thyrsopelma guianense (Diptera: Simuliidae), the primary vector of onchocerciasis in the Brazilian Amazon. (20428677)
2010
10
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
11
Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasis. (19008151)
2009
12
Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis. (18419585)
2008
13
Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern Nigeria. (18186977)
2008
14
After a decade of annual dose mass ivermectin treatment in Cameroon and Uganda, onchocerciasis transmission continues. (18631308)
2008
15
Infective larvae of five Onchocerca species from experimentally infected Simulium species in an area of zoonotic onchocerciasis in Japan. (18642503)
2008
16
Onchocerciasis (river blindness). Report from the sixteenth InterAmerican Conference on Onchocerciasis, Antigua Guatemala, Guatemala. (17763565)
2007
17
Molecular systematics of Simulium squamosum, the vector in the Kinsuka onchocerciasis focus (Kinshasa, Democratic Republic of Congo). (17362602)
2007
18
Cytogenetic and PCR-based identification of S. damnosum "Nkusi J" as the anthropophilic blackfly in the Uluguru onchocerciasis focus in Tanzania. (16827707)
2006
19
Consequences of vector behavior in epidemiology of onchocerciasis on the Firestone Rubber Plantation in Liberia. (16687689)
2006
20
Canine ocular onchocerciasis in the United States: two new cases and a review of the literature. (15644101)
2005
21
Report of a Scientific Working Group on Serious Adverse Events following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas. (14975059)
2004
22
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
23
Onchocerciasis (river blindness). Report from the thirteenth InterAmerican Conference on Onchocerciasis, Cartagena de Indias, Colombia. (15460014)
2004
24
Onchocerciasis. (15035021)
2003
25
Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis. (14584385)
2003
26
Profile of eye lesions and vision loss: a cross-sectional study in Lusambo, a forest-savanna area hyperendemic for onchocerciasis in the Democratic Republic of Congo. (12535256)
2003
27
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). (11825773)
2002
28
Rapid epidemiological mapping of onchocerciasis (REMO): its application by the African Programme for Onchocerciasis Control (APOC). (12081248)
2002
29
Subconjunctival zoonotic onchocerciasis in man: aberrant infection with Onchocerca lupi? (12194710)
2002
30
Human onchocerciasis in the Amazonian area of southern Venezuela: spatial and temporal variations in biting and parity rates of black fly (Diptera: Simuliidae) vectors. (11476332)
2001
31
Community-based ivermectin therapy for onchocerciasis: comparison of three methods of dose assessment. (11561701)
2001
32
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
33
A rapid-format antibody card test for diagnosis of onchocerciasis. (11069258)
2000
34
Dispersal range of Simulium neavei in an onchocerciasis focus of western Uganda. (10759318)
2000
35
Clinical and parasitological aspects of itching caused by onchocerciasis in Morogoro, Tanzania. (11214098)
2000
36
The prevalence of onchocerciasis and other parasitic infestations on an oil palm plantation in Ghana. (10902470)
2000
37
Onchocerca-Simulium complexes in Venezuela: can human onchocerciasis spread outside its present endemic areas? (10726276)
2000
38
Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. (10531253)
1999
39
Effect of repeated ivermectin treatments on ocular onchocerciasis: evaluation after six to eight doses. (10544338)
1999
40
Onchocerciasis. (9643811)
1998
41
Human onchocerciasis: current assessment of the disease burden in Nigeria by rapid epidemiological mapping. (9861272)
1998
42
Evaluation of community compliance with annual ivermectin treatment of onchocerciasis in Patigi, Nigeria. (9745842)
1998
43
IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis. (9605145)
1998
44
Onchocerciasis and reproductive health in Ecuador. (9231206)
1997
45
Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. (9357488)
1997
46
Gynaecomastia in onchocerciasis. (9142073)
1997
47
Reduction in incidence of optic nerve disease with annual ivermectin to control onchocerciasis. (8093742)
1993
48
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
49
Experimental ocular onchocerciasis in cynomolgus monkeys. III. Roles of IgG and IgE antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. (3175465)
1988
50
Onchocerciasis and optic atrophy in the Savannah area of Ghana. (3451406)
1987

Variations for Onchocerciasis

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Expression for genes affiliated with Onchocerciasis

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Search GEO for disease gene expression data for Onchocerciasis.

Pathways for genes affiliated with Onchocerciasis

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Pathways related to Onchocerciasis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.1CALR, IL5, EPX, RNASE3

Compounds for genes affiliated with Onchocerciasis

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Compounds related to Onchocerciasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tele-methylhistamine449.8EPX, RNASE3
2mometasone furoate44 6010.7IL5, RNASE3
3unicap449.7RNASE3, IL5
4levocabastine44 28 1111.7RNASE3, IL5
5sephadex449.7RNASE3, EPX
6beclomethasone dipropionate449.7RNASE3, IL5
7toluene diisocyanate449.7RNASE3, IL5
8nedocromil sodium449.6IL5, RNASE3
9pranlukast44 28 1111.6RNASE3, IL5
10praziquantel44 1110.6RNASE3, IL5
11azelastine44 1110.6RNASE3, IL5
12ltd4449.5RNASE3, IL5
13montelukast44 50 28 1112.4RNASE3, IL5
14percoll449.4RNASE3, IL5
15p005449.4EPX, RNASE3
16sodium cromoglycate449.3EPX, IL5, RNASE3
17lte4449.3EPX, IL5, RNASE3
18cetirizine44 28 24 1112.3EPX, IL5, RNASE3
19salmeterol44 50 28 1112.3IL5, EPX, RNASE3
20ketotifen44 1110.3IL5, EPX, RNASE3
21ltc4449.3RNASE3, EPX, IL5
22budesonide44 50 1111.3IL5, EPX, RNASE3
23salbutamol44 50 28 24 1113.3EPX, RNASE3, IL5
24pgd2449.3RNASE3, IL5, EPX
25allergens449.3RNASE3, EPX, IL5
26theophylline44 28 24 1112.3RNASE3, EPX, IL5
27leukotriene b444 60 2411.3IL5, RNASE3, EPX
28gliadin449.3RNASE3, CALR
29prednisolone44 28 1111.3IL5, RNASE3, EPX
30butyrate449.2RBP3, EPX, IL5
31formaldehyde44 2410.2RNASE3, EPX, TUBB
32fmlp449.2RNASE3, EPX, IL5
33melatonin44 28 60 24 1113.1TUBB, CALR, EPX
34fluticasone propionate44 50 60 1112.0IL5, RNASE3
35con a449.0IL5, CALR
36chloride449.0CALR, TUBB, EPX
37urea44 24 1110.9CALR, RNASE3, TUBB
38glutamine448.6RBP3, CALR, IL5, TUBB
39histamine44 28 2410.5CALR, IL5, RNASE3, EPX
40lactate448.5CALR, RNASE3, TUBB, EPX
41heparin44 28 24 1111.5CALR, RNASE3, IL5, EPX
42steroid448.4EPX, TUBB, RNASE3, CALR
43dexamethasone44 50 28 1111.4CALR, IL5, EPX, RNASE3
44adenylate448.4CALR, TUBB, RNASE3, IL5
45cysteine448.3EPX, CALR, IL5, TUBB
46retinoic acid44 249.3RBP3, IL5, CALR, RNASE3
47nitric oxide44 24 1110.1TUBB, RNASE3, EPX, RBP3, CALR
48lipid448.1TUBB, RNASE3, CALR, EPX
49h2o2448.0IL5, CALR, EPX, TUBB, RNASE3
50tyrosine447.9EPX, CALR, RNASE3, IL5, TUBB

GO Terms for genes affiliated with Onchocerciasis

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Cellular components related to Onchocerciasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1RBP3, CALR, IL5, RNASE3

Sources for Onchocerciasis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet