MCID: ONC002
MIFTS: 56

Onchocerciasis malady

Infectious diseases category

Summaries for Onchocerciasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A filariasis that involves parasitic infection caused by the nematode onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus simulium. the worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. the symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

MalaCards: Onchocerciasis, also known as infection by onchocerca volvulus, is related to schistosomiasis and skin disease. An important gene associated with Onchocerciasis is RBP3 (retinol binding protein 3, interstitial), and among its related pathways are Selected targets of GCR-alpha and Chemokine receptors bind chemokines. The drug ivermectin and the compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

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Wikipedia:63 Onchocerciasis (/ˈɒŋkɵsɜrˈsaɪ.əsɨs/ or /ˈɒŋkɵsɜrˈkaɪ.əsɨs/), also known as river... more...

Aliases & Classifications for Onchocerciasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
onchocerciasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

onchocerciasis 8 42 10 44 48 60
infection by onchocerca volvulus 8
onchocerca volvulus infection 8
onchocerciasis, ocular 60
river blindness 42
robles' disease 42
volvulosis 8


External Ids:

Disease Ontology8 DOID:11678
ICD9CM27 125.3
NCIt39 C34861
MeSH34 D009855
ICD10 via Orphanet26 B73
SNOMED-CT56 38539003
SNOMED-CT via Orphanet57 240842000, 38539003
UMLS via Orphanet61 C0029001, C0029002
MESH via Orphanet35 D009855, D015827
ICD1025 B73

Related Diseases for Onchocerciasis

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17GeneCards, 18GeneDecks
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Diseases related to Onchocerciasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis30.6IL5, RNASE3
2skin disease30.2CCL11, CCL27, S100A8, DSG1, RNASE3, IL5
3malaria30.0CCL5
4eosinophilia30.0CCL11, CCL5, CCL27, EPX, RNASE3, RNASE2
5leishmaniasis29.8MPI, IL5
6tuberculosis29.8EPX, LBR, CALR
7dermatitis29.8CCL11, CCL27, DSG1, IL5
8filariasis10.6
9loiasis10.4
10chorioretinitis10.2
11trachoma10.1
12chagas disease10.1
13dracunculiasis10.1
14elephantiasis10.1
15optic nerve disease10.1
16urinary schistosomiasis10.0
17cysticercosis10.0
18intestinal schistosomiasis10.0
19mansonelliasis10.0
20epilepsy syndrome10.0
21optic atrophy10.0
22tetanus10.0
23corneal disease10.0
24diabetes mellitus10.0CALR
25bronchitis10.0RNASE3
26paragonimiasis10.0IL5
27strongyloidiasis10.0IL5
28lupus erythematosus10.0CALR
29celiac disease10.0CALR
30hepatitis b10.0CCL27
31kawasaki disease10.0S100A12
32duodenitis10.0S100A8
33intrinsic asthma10.0IL5, RNASE3
34pemphigus10.0DSG1
35chronic rhinitis10.0RNASE3
36kimura disease10.0RNASE3, IL5
37folliculitis10.0CCL11
38herpes gestationis10.0RNASE3
39hypersensitivity reaction type ii disease10.0DSG1
40eosinophilic gastroenteritis10.0IL5, CCL11
41uveitis10.0RBP3, CCL11
42churg-strauss syndrome10.0IL5, RNASE3
43helminthiasis10.0RNASE3, IL5
44common cold10.0CCL11, RNASE3
45gastroesophageal reflux disease10.0S100A8
46otitis media10.0CCL11, RNASE3
47primary biliary cirrhosis10.0LBR
48hepatitis10.0CCL27, CCL11
49asthma10.0IL5, RNASE3, EPX
50vasculitis10.0RBP3, S100A12

Graphical network of the top 20 diseases related to Onchocerciasis:



Diseases related to onchocerciasis

Clinical Features for Onchocerciasis

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Drugs & Therapeutics for Onchocerciasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Onchocerciasis

Drug clinical trials:

Search ClinicalTrials for Onchocerciasis

Search NIH Clinical Center for Onchocerciasis

Search CenterWatch for Onchocerciasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Onchocerciasis

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Anatomical Context for Onchocerciasis

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32MalaCards
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MalaCards organs/tissues related to Onchocerciasis:

32
Skin, Eye, Testes, Lymph node, Salivary gland, Breast, T cells

Animal Models for Onchocerciasis or affiliated genes

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Publications for Onchocerciasis

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Sources:
50PubMed
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Articles related to Onchocerciasis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. (23866958)
2014
2
Rapid epidemiological assessment of onchocerciasis in a tropical semi-urban community, enugu state, Nigeria. (23682272)
2013
3
Fifteen years of annual mass treatment of onchocerciasis with ivermectin have not interrupted transmission in the west region of cameroon. (23691275)
2013
4
Transmission of onchocerciasis in wadelai focus of northwestern Uganda has been interrupted and the disease eliminated. (22970347)
2012
5
A rare case of ocular onchocerciasis in India. (22299403)
2011
6
Prevalence and distribution of ocular onchocerciasis in three ecological zones in Nigeria. (21735992)
2010
7
Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda). (20524133)
2010
8
Onchocerciasis Control: Vision for the Future from a Ghanian perspective. (19154624)
2009
9
Eye disease related to onchocerciasis: a clinical study in the Aratha-A_, Yanomami Tribe, Roraima State, Brazil. (19595662)
2009
10
Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure. (19901988)
2009
11
The Onchocerciasis Elimination Program for the Americas (OEPA). (18718151)
2008
12
Onchocerciasis control: biological research is still needed. (18814732)
2008
13
Adverse reactions from community directed treatment with ivermectin (CDTI) for onchocerciasis and loiasis in Ondo State, Nigeria. (19419072)
2008
14
Onchocerciasis (river blindness). Report from the sixteenth InterAmerican Conference on Onchocerciasis, Antigua Guatemala, Guatemala. (17763565)
2007
15
Proteinuria and onchocerciasis in an endemic area in Cameroon under community-based treatment with ivermectin. (17716503)
2007
16
Control of onchocerciasis--the next generation. (17574078)
2007
17
Taxonomy and inventory of the cytospecies and cytotypes of the Simulium damnosum complex (Diptera: Simuliidae) in relation to onchocerciasis. (18045261)
2007
18
Consequences of vector behavior in epidemiology of onchocerciasis on the Firestone Rubber Plantation in Liberia. (16687689)
2006
19
Ivermectin and onchocerciasis: is it all solved? (16304585)
2005
20
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
21
Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas disease suggest a possible etiological link to Fogo selvagem. (15610512)
2004
22
Additional health and development activities for community-directed distributors of ivermectin: threat or opportunity for onchocerciasis control? (15303994)
2004
23
Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness). (15385467)
2004
24
Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future. (14975064)
2003
25
Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasis. (14613509)
2003
26
Mass drug treatment for lymphatic filariasis and onchocerciasis. (14580963)
2003
27
Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients. (14975062)
2003
28
The effect of 5 years of annual treatment with ivermectin (Mectizan) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic. (12061976)
2002
29
Implementing community-directed treatment with ivermectin for the control of onchocerciasis in Uganda (1997-2000): an evaluation. (11998803)
2002
30
Onchocerca-Simulium complexes in Venezuela: can human onchocerciasis spread outside its present endemic areas? (10726276)
2000
31
Knowledge and beliefs about causes, transmission, treatment and control of human onchocerciasis in rural communities in south western Nigeria. (10974165)
2000
32
Programmatic goals and approaches to onchocerciasis. (10905239)
2000
33
Controlling onchocerciasis by community-directed, ivermectin-treatment programmes in Uganda: why do some communities succeed and others fail? (10945044)
2000
34
Immunity to onchocerciasis: cells from putatively immune individuals produce enhanced levels of interleukin-5, gamma interferon, and granulocyte-macrophage colony-stimulating factor in response to Onchocerca volvulus larval and male worm antigens. (10722581)
2000
35
The community-directed, ivermectin-treatment programme for onchocerciasis control in Uganda--an evaluative study (1993-1997). (10715701)
1999
36
Prenatal immune priming in onchocerciasis-onchocerca volvulus-specific cellular responsiveness and cytokine production in newborns from infected mothers. (10403926)
1999
37
Control of onchocerciasis: challenges for the future. (9861269)
1998
38
Onchocerciasis: the burden of disease. (9861275)
1998
39
Mast cell distribution in nodules of Onchocerca volvulus from untreated patients with generalized onchocerciasis. (9550219)
1998
40
Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10. (9806045)
1998
41
Rapid assessment of onchocerciasis prevalence and a model for selecting communities for ivermectin distribution in West Africa. (9241809)
1997
42
RANTES in onchocerciasis: changes with ivermectin treatment. (8973613)
1996
43
Red-dot card test of the paracentral field as a screening test for optic nerve disease in onchocerciasis. (9060216)
1996
44
Experimental ocular onchocerciasis in cynomolgus monkeys. IV. Chorioretinitis elicited by Onchocerca volvulus microfilariae. (2016131)
1991
45
Immunoregulation in onchocerciasis. Functional and phenotypic abnormalities of lymphocyte subsets and changes with therapy. (1829096)
1991
46
Immunity to onchocerciasis: recognition of larval antigens by humans putatively immune to Onchocerca volvulus infection. (2019761)
1991
47
Humoral autoimmune response against S-antigen and IRBP in ocular onchocerciasis. (2365568)
1990
48
Humoral and cell-mediated immune response against human retinal antigens in relation to ocular onchocerciasis. (2378211)
1990
49
Experimental ocular onchocerciasis in cynomolgus monkeys. III. Roles of IgG and IgE antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae. (3175465)
1988
50
The risk of optic atrophy following suramin treatment of ocular onchocerciasis. (314359)
1979

Genetic Variations for Onchocerciasis

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Expression for genes affiliated with Onchocerciasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Onchocerciasis

Search GEO for disease gene expression data for Onchocerciasis.

Pathways for genes affiliated with Onchocerciasis

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12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Onchocerciasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL5, CCL11, TUBB
29.9CCL11, CCL5, CCL27
3
Hide members
9.8IL5, RNASE3, EPX, CALR, CCL11

Compounds for genes affiliated with Onchocerciasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Onchocerciasis according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1unicap4410.4CCL11, IL5, RNASE3
2anti-histamine4410.4CCL11, CCL5, RNASE3
3sodium cromoglycate4410.3EPX, CCL11, IL5, RNASE3
4lte44410.3CCL11, EPX, RNASE3, IL5
5cetirizine44 28 11 2413.3IL5, RNASE3, EPX, CCL11
65-oxoete4410.3CCL11, CCL5, IL5
7ketotifen44 1111.3EPX, CCL11, RNASE3, IL5
8ltc44410.3RNASE3, IL5, EPX, CCL11
9butyrate4410.3CCL11, IL5, RBP3
10salbutamol44 49 28 11 2414.3RNASE3, EPX, CCL11, IL5
11pgd24410.3IL5, CCL11, EPX, RNASE3
12montelukast44 49 28 1113.3IL5, CCL11, RNASE3
13pranlukast44 28 1112.3RNASE3, IL5, CCL11, CCL5
14Adenosine-2'-5'-Diphosphate1110.3RNASE3, RNASE2
15fluticasone propionate44 49 59 1113.2CCL5, IL5, RNASE3, CCL11
16percoll4410.2RNASE3, CCL5, IL5
17methacholine44 1111.2RNASE3, CCL11, CCL5, IL5
18clarithromycin44 1111.2IL5, S100A8, CCL11
19melatonin44 59 28 11 2414.2LBR, TUBB, CALR, EPX
20salmeterol44 49 28 1113.2CCL5, CCL11, EPX, IL5, RNASE3
21budesonide44 49 1112.2EPX, RNASE3, IL5, CCL5, CCL11
22rantes4410.2RNASE3, LBR, S100A8, CCL11
23tarc4410.1CCL27, CCL5, CCL11, IL5
24p0054410.1RNASE3, EPX, S100A8, CCL5
25con a4410.1IL5, LBR, CALR
26leukotriene b444 59 2412.1CCL5, EPX, RNASE3, IL5, CCL11
27prednisolone44 28 1112.1CCL11, RNASE3, IL5, EPX
28fmlp4410.0CCL5, IL5, RNASE3, CCL11, EPX
29rolipram44 59 2812.0EPX
30ionomycin4410.0LBR, CCL11, CALR, IL5, CCL5
31poly(i-c)4410.0CCL5, CCL11, IL5
32urea44 11 2412.0CALR, TUBB, RNASE3, S100A8
33heparin44 28 11 2412.9CCL11, CCL5, CALR, LBR, EPX, RNASE3
34allergens449.9IL5, CCL11, CCL27, S100A8, EPX, RNASE3
35serine449.9TUBB, EPX, DSG1, S100A8, CCL5
36pge2449.8CCL27, EPX, CCL5, RNASE3, IL5, CCL11
37h2o2449.7RNASE3, TUBB, IL5, CCL5, CALR, LBR
38superoxide44 2410.7MPI, EPX, LBR, S100A8, CCL11, CALR
39creatinine449.7CCL5, TUBB, CCL27, S100A8, EPX, RNASE3
40endotoxin449.6RNASE3, CCL11, CCL5, S100A8
41histamine44 28 2411.6CCL5, LBR, CALR, CCL11, S100A8, EPX
42steroid449.6EPX, RNASE3, LBR, CCL11, TUBB, CALR
43zinc44 2410.5MPI, RBP3, LBR, S100A8, S100A12, CALR
44nitric oxide44 11 2411.4CALR, CCL5, S100A8, LBR, RBP3, EPX
45retinoic acid44 2410.4IL5, RNASE3, DSG1, RBP3, LBR, S100A8
46cysteine449.3EPX, TUBB, CCL5, CALR, IL5, LBR
47dexamethasone44 49 28 1112.3EPX, LBR, S100A8, CALR, CCL27, CCL5
48tyrosine449.2LBR, RNASE3, EPX, CCL11, CCL5, CALR
49lipid449.1CCL27, RNASE3, EPX, CD226, LBR, TUBB
50calcium44 49 11 2411.9DSG1, LBR, S100A12, CALR, CCL27, EPX

GO Terms for genes affiliated with Onchocerciasis

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16Gene Ontology
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Cellular components related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0CCL5, CCL27, CALR, S100A8, RBP3, IL5
2extracellular regionGO:0055768.4IL5, CCL11, CCL5, CCL27, CALR, S100A12

Biological processes related to Onchocerciasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.3CCL11, CCL5
2chronic inflammatory responseGO:00254410.2CCL11, S100A8
3positive regulation of JAK-STAT cascadeGO:04642710.2IL5, CCL5
4RNA catabolic processGO:00640110.1RNASE2, RNASE3
5cellular calcium ion homeostasisGO:00687410.0CALR, CCL5, CCL11
6chemotaxisGO:0069359.9RNASE2, CCL27, CCL5, CCL11
7monocyte chemotaxisGO:0025489.8S100A12, CCL5
8defense response to bacteriumGO:0427429.8S100A12, S100A8, RNASE3
9inflammatory responseGO:0069549.7CCL11, CCL5, S100A12, S100A8, IL5

Molecular functions related to Onchocerciasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.1RNASE2, RNASE3
2RAGE receptor bindingGO:0507869.9S100A8, S100A12
3chemokine activityGO:0080099.9CCL27, CCL5, CCL11
4ribonuclease activityGO:0045409.8RNASE2, RNASE3

Products for genes affiliated with Onchocerciasis

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Sources for Onchocerciasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet