OO
MCID: ONC003
MIFTS: 51

Oncogenic Osteomalacia (OO) malady

Rare diseases, Bone diseases, Endocrine diseases, Cancer diseases categories

Summaries for Oncogenic Osteomalacia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Tumor-induced osteomalacia, also known as oncogenic hypophosphatemic osteomalacia or oncogenic... more...

MalaCards: Oncogenic Osteomalacia, also known as oncogenic hypophosphatemic osteomalacia, is related to osteomalacia and paraneoplastic syndromes. An important gene associated with Oncogenic Osteomalacia is FGF23 (fibroblast growth factor 23), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Signaling by FGFR1 mutants. The compounds bim 23030 and boc-ate have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and colon, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Aliases & Classifications for Oncogenic Osteomalacia

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44NIH Rare Diseases, 50Orphanet, 63UMLS, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

50
oncogenic osteomalacia:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

oncogenic osteomalacia 44 50 63
oncogenic hypophosphatemic osteomalacia 50
tumor-induced osteomalacia 50
oom 44
tio 50
oo 44


External Ids:

ICD10 via Orphanet27 M83.8

Related Diseases for Oncogenic Osteomalacia

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18GeneCards, 19GeneDecks
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Diseases related to Oncogenic Osteomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1osteomalacia31.5FGF23, DMP1, PHEX, CALCA, MEPE, PTH1R
2paraneoplastic syndromes30.6FGF23, PHEX
3hyperparathyroidism30.6FGF23, PHEX, CALCA, PTH
4rickets30.5DMP1, SFRP4, PTH, MEPE, PHEX, FGF23
5hypophosphatemia30.5DMP1, SFRP4, PTH, MEPE, CALCA, PHEX
6x-linked hypophosphatemia30.5DMP1, PTH, MEPE, PHEX, FGF23
7giant cell tumor30.2FGF23, CALCA
8prostate cancer30.1FGF7, SSTR2, SSTR1, SSTR5, PTH1R, SFRP4
9primary hyperparathyroidism30.1PTH, PTH1R, CALCA, FGF23
10osteosarcoma30.0MEPE, PTH1R, PTH
11hemangiopericytoma10.4
12prostatitis10.4
13hemangioma10.3
14neurofibromatosis10.2
15fanconi syndrome10.2
16fibrous dysplasia10.1
17uremia10.1
18osteomalacia, tumor-induced10.1
19avascular necrosis of the femoral head10.1
20hypervitaminosis d10.1FGF23
21dentin dysplasia10.1MEPE
22osteitis fibrosa10.1PTH
23fibroma10.1
24adenocarcinoma10.1
25cervicitis10.1
26chondrosarcoma10.1
27colon adenocarcinoma10.1
28meningitis10.1
29mesenchymal chondrosarcoma10.1
30plasmacytoma10.1
31renal cell carcinoma10.1
32syndrome of inappropriate antidiuretic hormone10.1
33sinusitis10.1
34myopericytoma10.1
35chondromyxoid fibroma10.1
36dentinogenesis imperfecta10.1DMP1, MEPE
37calcinosis10.1PTH, FGF23
38glucagonoma10.1SSTR2, SSTR5
39hyperphosphatemia10.0SFRP4, PTH, FGF23
40multiple endocrine neoplasia type 2a10.0CALCA, PTH
41autosomal dominant disease10.0PTH, CALCA
42somatostatinoma10.0SSTR2, CALCA
43nephrolithiasis10.0PTH, FGF23
44adenoiditis10.0
45adenoid cystic carcinoma10.0
46overuse syndrome10.0
47thromboembolism10.0
48venous thromboembolism10.0
49gastrinoma10.0SSTR5, SSTR1, SSTR2
50parathyroid adenoma10.0PTH, CALCA

Graphical network of the top 20 diseases related to Oncogenic Osteomalacia:



Diseases related to oncogenic osteomalacia

Symptoms for Oncogenic Osteomalacia

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Drugs & Therapeutics for Oncogenic Osteomalacia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Oncogenic Osteomalacia

Drug clinical trials:

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Search NIH Clinical Center for Oncogenic Osteomalacia

Search CenterWatch for Oncogenic Osteomalacia

Genetic Tests for Oncogenic Osteomalacia

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Anatomical Context for Oncogenic Osteomalacia

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34MalaCards
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MalaCards organs/tissues related to Oncogenic Osteomalacia:

34
Bone, Prostate, Colon, Kidney, Lung, Breast

Animal Models for Oncogenic Osteomalacia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Oncogenic Osteomalacia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9DMP1, PTH, PTH1R, PHEX, FGF23
2MP:00053818.7FGF23, PHEX, SSTR2, PTH1R, SFRP4
3MP:00053678.2SFRP4, CALCA, PHEX, FGF7, FGF23
4MP:00053908.1DMP1, PTH, PTH1R, MEPE, CALCA, PHEX
5MP:00053766.6FGF23, SFRP4, PTH, PTH1R, SSTR5, SSTR1

Publications for Oncogenic Osteomalacia

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53PubMed
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Articles related to Oncogenic Osteomalacia:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
2
Diagnostic Findings and Treatment in a 51-Year-Old Woman With Oncogenic Osteomalacia. (24423314)
2013
3
Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia. (23618679)
2013
4
Oncogenic osteomalacia from nasal cavity giant cell tumor. (22311466)
2012
5
Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. (23372968)
2012
6
Oncogenic osteomalacia should be considered in hypophosphatemia, bone pain and pathological fractures. (22744630)
2012
7
Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia. (21739089)
2012
8
Oncogenic osteomalacia: loss of hypophosphatemia might be the key to avoid misdiagnosis. (23295300)
2012
9
Comparison of whole body diffusion weighted magnetic resonance imaging and somatostatin receptor scintigraphy for oncogenic osteomalacia. (23134817)
2012
10
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
11
Dual paraneoplastic syndromes: small cell lung carcinoma-related oncogenic osteomalacia, and syndrome of inappropriate antidiuretic hormone secretion: report of a case and review of the literature. (21886301)
2011
12
Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction. (21275557)
2011
13
Oncogenic osteomalacia in a patient with an ethmoid sinus tumour. (20003602)
2010
14
Bilateral insufficiency fracture of the femoral head and neck in a case of oncogenic osteomalacia. (20595128)
2010
15
Interesting image. The search for primary tumor in a patient with oncogenic osteomalacia: F-18 FDG PET resolves the conundrum. (20940555)
2010
16
Somatostatin receptor expression in an epitheloid hemangioma causing oncogenic osteomalacia. (19789203)
2009
17
Oncogenic osteomalacia from pterygopalatine fossa mass. (19250593)
2009
18
A phosphaturic mesenchymal tumor of the floor of the mouth with oncogenic osteomalacia: report of a case. (19138617)
2009
19
Phosphaturic mesenchymal tumour-mixed connective tissue variant without oncogenic osteomalacia. (19638551)
2009
20
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. (19441990)
2009
21
Rapid detection of intact FGF-23 in tumor tissue from patients with oncogenic osteomalacia. (18593970)
2008
22
Oncogenic osteomalacia, a rare paraneoplastic syndrome due to phosphate wasting--a case report and review of the literature. (19000546)
2008
23
Oncogenic osteomalacia: muscular weakness and multiple fractures. (16864847)
2006
24
Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies. (16912362)
2006
25
Oncogenic osteomalacia caused by phosphaturic mesenchymal tumor of the temporal bone. (17011438)
2006
26
Oncogenic osteomalacia cured by removal of an organized hematoma. (16239206)
2005
27
Case 3. Oncogenic osteomalacia associated with hemangiopericytoma localized by octreotide scan. (15908675)
2005
28
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12890852)
2003
29
Oncogenic osteomalacia--a complex dance of factors. (12711747)
2003
30
Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia. (12970268)
2003
31
Bone and In-111 octreotide imaging in oncogenic osteomalacia: a case report. (12170004)
2002
32
Oncogenic osteomalacia. (12541196)
2002
33
Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. (11581007)
2001
34
Extracts from tumors causing oncogenic osteomalacia inhibit phosphate uptake in opossum kidney cells. (11375132)
2001
35
Oncogenic osteomalacia associated with soft tissue chondromyxoid fibroma. (11522411)
2001
36
Oncogenic osteomalacia. (11344782)
2000
37
Oncogenic osteomalacia secondary to a hemangiopericytoma of the hip: case report. (10047746)
1999
38
Oncogenic osteomalacia presenting as bilateral stress fractures of the tibia. (10068075)
1999
39
Diagnostic utility of magnetic resonance imaging skeletal survey in a patient with oncogenic osteomalacia. (10495143)
1999
40
Bone scintigraphy in a case of oncogenous osteomalacia. (9676956)
1998
41
Oncogenic osteomalacia: evidence for a humoral phosphaturic factor. (7745010)
1995
42
Oncogenic osteomalacia. (8084347)
1994
43
Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. (8177270)
1994
44
Oncogenic osteomalacia: imaging studies. (8387360)
1993
45
Oncogenic osteomalacia associated with metastatic prostate carcinoma: case report and review of the literature. (8409185)
1993
46
A neuroendocrine cause of oncogenic osteomalacia. (1378890)
1992
47
Oncogenic osteomalacia. A case report. (2743673)
1989
48
Oncogenic osteomalacia. (2983596)
1985
49
Oncogenic osteomalacia and renal adenomatoid dysplasia. (4039546)
1985
50
Oncogenic osteomalacia. (6469602)
1984

Variations for Oncogenic Osteomalacia

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Expression for genes affiliated with Oncogenic Osteomalacia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oncogenic Osteomalacia

Search GEO for disease gene expression data for Oncogenic Osteomalacia.

Pathways for genes affiliated with Oncogenic Osteomalacia

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Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 13EMD Millipore, 31KEGG
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Pathways related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PTH, PTH1R
2
Show member pathways
9.7FGF7, FGF23
39.5FGF23, PTH1R, PTH
4
Show member pathways
9.4PTH, PTH1R, CALCA
59.4CALCA, PTH1R, PTH
69.4PTH, PTH1R, CALCA
7
Show member pathways
Peptide GPCRs39
8.4SSTR2, SSTR3, SSTR1, SSTR5
8
Show member pathways
7.3CALCA, PTH, SSTR3, SSTR2, SSTR1, SSTR5
9
Show member pathways
6.5PTH, SSTR5, SSTR1, SSTR2, SSTR3, CALCA

Compounds for genes affiliated with Oncogenic Osteomalacia

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30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1bim 23030309.4SSTR5, SSTR2, SSTR3
2boc-ate309.4SSTR5, SSTR2, SSTR3
3[111in,90y]dota-oc309.3SSTR5, SSTR2, SSTR3
4[111in,90y]dota-lan309.3SSTR3, SSTR2, SSTR5
5bim 23056309.3SSTR3, SSTR2, SSTR5
6noc-ate309.3SSTR5, SSTR2, SSTR3
7[111in,90y]dota-toc309.3SSTR3, SSTR2, SSTR5
8l-363,301309.3SSTR5, SSTR2, SSTR3
9[111in]dota-noc-ate309.3SSTR3, SSTR2, SSTR5
10[111in]dota-noc309.2SSTR5, SSTR2, SSTR3
11bim 23023309.2SSTR5, SSTR2, SSTR3
12[111in]dota-boc-ate309.2SSTR5, SSTR2, SSTR3
13111in-pentetreotide469.2SSTR2, SSTR5, SSTR1, CALCA
14mk-678309.2SSTR3, SSTR5, SSTR2
15phosphorus469.2PHEX, CALCA, FGF23, PTH1R, PTH
16bim 23197309.1SSTR5, SSTR2, SSTR3
17[111in,90y]dota-noc309.1SSTR5, SSTR2, SSTR3
18vapreotide46 30 1211.0SSTR3, SSTR2, SSTR5
19nc 4-28b308.9SSTR1, SSTR2, SSTR3
20som-230308.9SSTR1, SSTR2, SSTR3, SSTR5
21[125i]ltt-srif-28308.8SSTR2, SSTR3, SSTR1, SSTR5
22cst-17308.8SSTR2, SSTR3, SSTR5, SSTR1
23bim 23052308.8SSTR2, SSTR1, SSTR5, SSTR3
24cgp 23996308.8SSTR3, SSTR2, SSTR1, SSTR5
25ke 108308.8SSTR3, SSTR2, SSTR5, SSTR1
26srif-28308.8SSTR1, SSTR5, SSTR2, SSTR3
27[125i]cgp 23996308.8SSTR3, SSTR2, SSTR1, SSTR5
28[125i]tyr10-cst14308.8SSTR3, SSTR2, SSTR1, SSTR5
29srif-14308.8SSTR3, SSTR2, SSTR1, SSTR5
30[l-tyr8]cyn 154806308.8SSTR1, SSTR2, SSTR3, SSTR5
31bim 23454308.8SSTR5, SSTR1, SSTR2, SSTR3
32bim 23627308.8SSTR5, SSTR1, SSTR2, SSTR3
33l-362,855308.8SSTR1, SSTR5, SSTR2, SSTR3
34pasireotide46 129.8SSTR5, SSTR2, SSTR3, SSTR1
35[d-tyr8]cyn 154806308.8SSTR5, SSTR1, SSTR2, SSTR3
36(1r,1s,3r/1r,1r,3s)-l-054,264628.8SSTR3, SSTR2, SSTR1, SSTR5
37cst-14308.8SSTR1, SSTR3, SSTR5, SSTR2
38cyn 154806628.8SSTR2, SSTR5, SSTR1, SSTR3
39cyclosomatostatin628.8SSTR3, SSTR2, SSTR1, SSTR5
40somatostatin62 259.8SSTR2, SSTR1, SSTR5, SSTR3
41lanreotide46 309.8SSTR5, SSTR2, SSTR1, SSTR3
42bim 23050308.8SSTR5, SSTR1, SSTR3
431,25 dihydroxy vitamin d3468.7PTH1R, CALCA, PHEX, FGF23, PTH, FGF7
4425-hydroxyvitamin d468.7CALCA, FGF23, PTH, SFRP4
45des-aa5-[d-trp8]srif308.6SSTR3, SSTR1, SSTR5
46vitamin d468.4PTH, PTH1R, FGF23, DMP1, PHEX, CALCA
47ribonucleic acid468.4PTH1R, SSTR5, FGF7, SSTR2, PTH, SSTR1
48calcitriol46 62 25 1211.3PTH, SFRP4, PTH1R, MEPE, CALCA, FGF23
49octreotide46 62 30 1211.2SSTR1, SSTR5, FGF23, CALCA, SSTR3, SSTR2
50calcium46 52 25 129.6FGF23, SSTR2, SSTR5, CALCA, PTH1R, PTH

GO Terms for genes affiliated with Oncogenic Osteomalacia

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17Gene Ontology
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Cellular components related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4DMP1, PTH, CALCA, FGF7, FGF23
2integral component of plasma membraneGO:0058877.6PHEX, SSTR3, SSTR2, SSTR1, SSTR5, PTH1R
3cytoplasmGO:0057377.1CALCA, SSTR3, SSTR2, SSTR1, PTH1R, SFRP4

Biological processes related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of bone mineralizationGO:03050210.0FGF23, MEPE
2bone resorptionGO:04545310.0PTH1R, PTH
3phosphate ion homeostasisGO:05506210.0SFRP4, FGF23
4bone mineralizationGO:0302829.9PHEX, PTH1R
5biomineral tissue developmentGO:0312149.9MEPE, DMP1
6positive regulation of cAMP biosynthetic processGO:0308199.7CALCA, PTH
7vasculature developmentGO:0019449.7SFRP4, CALCA
8somatostatin signaling pathwayGO:0381709.7SSTR3, SSTR5
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.7PTH, PTH1R, CALCA
10hormone-mediated apoptotic signaling pathwayGO:0086289.6PTH, SSTR3
11cellular response to glucocorticoid stimulusGO:0713859.5SSTR3, SSTR2
12G-protein coupled receptor signaling pathwayGO:0071869.4PTH, PTH1R, SSTR5
13skeletal system developmentGO:0015019.3PTH, PTH1R, MEPE, PHEX
14digestionGO:0075869.2SSTR2, SSTR1
15cellular response to estradiol stimulusGO:0713929.0SSTR3, SSTR2, SSTR1
16cerebellum developmentGO:0215499.0SSTR3, SSTR2, SSTR1
17response to starvationGO:0425949.0SSTR1, SSTR2, SSTR3
18forebrain developmentGO:0309009.0SSTR3, SSTR2, SSTR1
19spermatogenesisGO:0072838.7SSTR3, SSTR2, SSTR1
20G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071878.4SSTR3, SSTR2, SSTR1, SSTR5, PTH1R
21cell-cell signalingGO:0072678.0PTH, SSTR1, SSTR2, SSTR3, CALCA, PHEX
22negative regulation of cell proliferationGO:0082857.8SFRP4, PTH1R, SSTR5, SSTR1, SSTR2, SSTR3

Molecular functions related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049948.4SSTR3, SSTR2, SSTR1, SSTR5

Products for genes affiliated with Oncogenic Osteomalacia

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  • Antibodies
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Sources for Oncogenic Osteomalacia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet