OO
MCID: ONC003
MIFTS: 39

Oncogenic Osteomalacia (OO) malady

Bone diseases, Endocrine diseases, Cancer diseases categories

Summaries for Oncogenic Osteomalacia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tumor-induced osteomalacia, also known as oncogenic hypophosphatemic osteomalacia or oncogenic... more...

MalaCards: Oncogenic Osteomalacia, also known as oncogenic hypophosphatemic osteomalacia, is related to osteomalacia and hypophosphatemia. An important gene associated with Oncogenic Osteomalacia is FGF23 (fibroblast growth factor 23), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Osteoblast Signaling. The compounds [111in,90y]dota-toc and boc-ate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Aliases & Classifications for Oncogenic Osteomalacia

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
oncogenic osteomalacia:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

oncogenic osteomalacia 42 48 60
oncogenic hypophosphatemic osteomalacia 48
tumor-induced osteomalacia 48
oom 42
tio 48
oo 42


External Ids:

ICD10 via Orphanet26 M83.8

Related Diseases for Oncogenic Osteomalacia

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17GeneCards, 18GeneDecks
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Diseases related to Oncogenic Osteomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1osteomalacia31.6PHEX, CALCA, SFRP4, PTH1R, DMP1, MEPE
2hypophosphatemia30.5PHEX, MEPE, FGF23, DMP1, CALCA, SFRP4
3hyperparathyroidism30.5CALCA, PTH, PHEX, FGF23
4rickets30.5SFRP4, FGF23, PTH, MEPE, DMP1, PHEX
5x-linked hypophosphatemia30.4DMP1, PTH, PHEX, FGF23, MEPE
6prostate cancer30.2SFRP4, SSTR5, SSTR2, SSTR1, FGF7, PTH1R
7fibrous dysplasia30.1FGF23
8uremia30.1PTH
9primary hyperparathyroidism30.1CALCA, FGF23, PTH, PTH1R
10giant cell tumor30.0FGF23, CALCA
11adenocarcinoma30.0SSTR1, FGF7, SSTR2
12hemangiopericytoma10.4
13prostatitis10.3
14hemangioma10.3
15neurofibromatosis10.2
16fanconi syndrome10.2
17axial osteomalacia10.1
18osteomalacia, tumor-induced10.1
19bone fracture10.0
20small cell carcinoma10.0
21adult syndrome10.0
22cervicitis10.0
23chondrosarcoma10.0
24colon adenocarcinoma10.0
25lung small cell carcinoma10.0
26meningitis10.0
27mesenchymal chondrosarcoma10.0
28osteosarcoma10.0
29plasmacytoma10.0
30renal cell carcinoma10.0
31adenoid cystic carcinoma10.0
32adenoiditis10.0
33graves' disease10.0FGF23
34hypervitaminosis d10.0FGF23
35dentin dysplasia10.0MEPE
36thyroiditis10.0CALCA
37hyperostosis10.0FGF23
38paraneoplastic syndromes10.0PHEX, FGF23
39leukemia10.0FGF7
40glucagonoma10.0SSTR2, SSTR5
41metaphyseal dysplasia10.0PTH1R
42metabolic acidosis10.0PTH
43osteitis fibrosa10.0PTH
44neuroendocrine tumor10.0SSTR2, CALCA
45dentinogenesis imperfecta10.0DMP1, MEPE
46calcinosis10.0PTH, FGF23
47parathyroid carcinoma10.0PTH
48acromegaly10.0SSTR5, SSTR2, SSTR1
49gastrinoma10.0SSTR1, SSTR5, SSTR2
50somatostatinoma10.0CALCA, SSTR2

Graphical network of the top 20 diseases related to Oncogenic Osteomalacia:



Diseases related to oncogenic osteomalacia

Clinical Features for Oncogenic Osteomalacia

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Drugs & Therapeutics for Oncogenic Osteomalacia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Oncogenic Osteomalacia

Drug clinical trials:

Search ClinicalTrials for Oncogenic Osteomalacia

Search NIH Clinical Center for Oncogenic Osteomalacia

Search CenterWatch for Oncogenic Osteomalacia

Genetic Tests for Oncogenic Osteomalacia

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Anatomical Context for Oncogenic Osteomalacia

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32MalaCards
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MalaCards organs/tissues related to Oncogenic Osteomalacia:

32
Bone

Animal Models for Oncogenic Osteomalacia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oncogenic Osteomalacia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.5FGF23, DMP1, PHEX
2MP:00053818.4PTH1R, FGF23, SSTR2, PHEX, SFRP4
3MP:00053908.1PTH, CALCA, PHEX, DMP1, MEPE, FGF23
4MP:00053677.9CALCA, SFRP4, PHEX, FGF7, FGF23
5MP:00053766.6CALCA, SFRP4, PHEX, SSTR5, SSTR2, SSTR1

Publications for Oncogenic Osteomalacia

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Genetic Variations for Oncogenic Osteomalacia

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Expression for genes affiliated with Oncogenic Osteomalacia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oncogenic Osteomalacia

Search GEO for disease gene expression data for Oncogenic Osteomalacia.

Pathways for genes affiliated with Oncogenic Osteomalacia

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Oncogenic Osteomalacia

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1[111in,90y]dota-toc289.7SSTR5, SSTR3, SSTR2
2boc-ate289.7SSTR5, SSTR2, SSTR3
3bim 23030289.7SSTR5, SSTR2, SSTR3
4[111in,90y]dota-oc289.7SSTR5, SSTR2, SSTR3
5bim 23197289.7SSTR5, SSTR2, SSTR3
6[111in,90y]dota-lan289.7SSTR3, SSTR2, SSTR5
7bim 23056289.7SSTR3, SSTR5, SSTR2
8noc-ate289.6SSTR5, SSTR2, SSTR3
9l-363,301289.6SSTR5, SSTR2, SSTR3
10[111in]dota-noc289.6SSTR5, SSTR2, SSTR3
11bim 23023289.6SSTR5, SSTR2, SSTR3
12[111in]dota-boc-ate289.6SSTR5, SSTR2, SSTR3
13[111in]dota-noc-ate289.5SSTR3, SSTR2, SSTR5
14[111in,90y]dota-noc289.5SSTR3, SSTR5, SSTR2
15mk-678289.4SSTR5, SSTR3, SSTR2
16vapreotide28 44 1111.4SSTR3, SSTR2, SSTR5
17nc 4-28b289.3SSTR2, SSTR1, SSTR3
18111in-pentetreotide449.2SSTR2, SSTR1, SSTR5, CALCA
19som-230289.2SSTR5, SSTR2, SSTR3, SSTR1
20srif-14289.2SSTR1, SSTR3, SSTR2, SSTR5
21[125i]tyr10-cst14289.2SSTR5, SSTR2, SSTR1, SSTR3
22[d-tyr8]cyn 154806289.2SSTR2, SSTR5, SSTR1, SSTR3
23[125i]ltt-srif-28289.2SSTR5, SSTR3, SSTR1, SSTR2
24l-362,855289.2SSTR1, SSTR2, SSTR5, SSTR3
25cst-17289.2SSTR1, SSTR3, SSTR2, SSTR5
26bim 23050289.2SSTR5, SSTR1, SSTR3
27srif-28289.2SSTR3, SSTR1, SSTR5, SSTR2
28bim 23052289.2SSTR5, SSTR2, SSTR1, SSTR3
29cgp 23996289.2SSTR3, SSTR1, SSTR2, SSTR5
30ke 108289.2SSTR3, SSTR1, SSTR2, SSTR5
31[125i]cgp 23996289.2SSTR1, SSTR2, SSTR5, SSTR3
32[l-tyr8]cyn 154806289.2SSTR3, SSTR2, SSTR1, SSTR5
33bim 23627289.2SSTR1, SSTR2, SSTR5, SSTR3
34bim 23454289.2SSTR3, SSTR1, SSTR2, SSTR5
35phosphorus449.2CALCA, PHEX, FGF23, PTH1R, PTH
36pasireotide44 1110.2SSTR5, SSTR2, SSTR1, SSTR3
37cst-14289.1SSTR1, SSTR2, SSTR5, SSTR3
38(1r,1s,3r/1r,1r,3s)-l-054,264599.1SSTR5, SSTR1, SSTR2, SSTR3
39cyclosomatostatin599.1SSTR1, SSTR5, SSTR2, SSTR3
40cyn 154806599.1SSTR5, SSTR2, SSTR1, SSTR3
41somatostatin59 2410.1SSTR5, SSTR1, SSTR2, SSTR3
42lanreotide44 2810.1SSTR1, SSTR2, SSTR5, SSTR3
43des-aa5-[d-trp8]srif289.0SSTR1, SSTR5, SSTR3
441,25 dihydroxy vitamin d3448.6PTH, FGF23, FGF7, PHEX, CALCA, PTH1R
45octreotide44 59 28 1111.5SSTR3, FGF23, CALCA, SSTR5, SSTR2, SSTR1
46vitamin d448.4PTH, FGF23, FGF7, DMP1, PHEX, CALCA
4725-hydroxyvitamin d448.3FGF23, SFRP4, CALCA, PTH
48ribonucleic acid448.0SSTR1, PTH, SSTR2, SSTR5, FGF7, PTH1R
49calcitriol44 59 11 2410.9CALCA, PTH, FGF23, PTH1R, MEPE, PHEX
50calcium44 49 11 249.3SSTR1, CALCA, SSTR5, PTH1R, FGF23, FGF7

GO Terms for genes affiliated with Oncogenic Osteomalacia

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16Gene Ontology
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Cellular components related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.1PTH1R, SSTR3, SSTR1, SSTR2, SSTR5, PHEX

Biological processes related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1somatostatin signaling pathwayGO:0381709.9SSTR3, SSTR5
2negative regulation of bone mineralizationGO:0305029.9FGF23, MEPE
3bone resorptionGO:0454539.8PTH1R, PTH
4hormone-mediated apoptotic signaling pathwayGO:0086289.8SSTR3, PTH
5cellular response to glucocorticoid stimulusGO:0713859.8SSTR2, SSTR3
6biomineral tissue developmentGO:0312149.7DMP1, MEPE
7positive regulation of cAMP biosynthetic processGO:0308199.7PTH, CALCA
8adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.6PTH, PTH1R, CALCA
9phosphate ion homeostasisGO:0550629.6FGF23, SFRP4
10vasculature developmentGO:0019449.6SFRP4
11bone mineralizationGO:0302829.5PTH1R, PHEX
12cellular response to estradiol stimulusGO:0713929.3SSTR3, SSTR1, SSTR2
13cerebellum developmentGO:0215499.3SSTR2, SSTR1, SSTR3
14skeletal system developmentGO:0015019.3PTH, PTH1R, MEPE, PHEX
15response to starvationGO:0425949.3SSTR2, SSTR1, SSTR3
16forebrain developmentGO:0309009.2SSTR3, SSTR1, SSTR2
17G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071878.7PTH1R, SSTR3, SSTR1, SSTR2, SSTR5
18cell-cell signalingGO:0072678.2CALCA, PHEX, SSTR2, SSTR1, SSTR3, PTH
19negative regulation of cell proliferationGO:0082857.9SFRP4, SSTR5, SSTR2, SSTR1, SSTR3, PTH1R

Molecular functions related to Oncogenic Osteomalacia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049948.7SSTR3, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Oncogenic Osteomalacia

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  • Antibodies
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Sources for Oncogenic Osteomalacia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet