MCID: ONC003
MIFTS: 40

Oncogenic Osteomalacia malady

Categories: Rare diseases, Bone diseases, Endocrine diseases

Aliases & Classifications for Oncogenic Osteomalacia

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Sources:
46NIH Rare Diseases, 52Orphanet, 66UMLS, 12diseasecard, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Oncogenic Osteomalacia:

Name: Oncogenic Osteomalacia 46 52 66
Tumor-Induced Osteomalacia 46 52
Oncogenic Hypophosphatemic Osteomalacia 52
Osteomalacia, Tumor-Induced 12
 
Oom 46
Tio 52
Oo 46

Characteristics:

Orphanet epidemiological data:

52
oncogenic osteomalacia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Orphanet52 ORPHA352540
ICD10 via Orphanet29 M83.8

Summaries for Oncogenic Osteomalacia

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Wikipedia:69 Tumor-induced osteomalacia, also known as oncogenic hypophosphatemic osteomalacia or oncogenic... more...

MalaCards based summary: Oncogenic Osteomalacia, also known as tumor-induced osteomalacia, is related to osteomalacia and jacobsen syndrome. An important gene associated with Oncogenic Osteomalacia is FGF23 (Fibroblast Growth Factor 23), and among its related pathways are Osteoblast Signaling and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, prostate and breast, and related mouse phenotypes are limbs/digits/tail and skeleton.

Related Diseases for Oncogenic Osteomalacia

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Diseases related to Oncogenic Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1osteomalacia10.9
2jacobsen syndrome10.6FGF23, PHEX
3familial wilms tumor 210.5FGF23, PHEX
4colorectal cancer, hereditary nonpolyposis, type 410.5DMP1, FGF23
5atelosteogenesis10.4FGF23, PHEX
6cystic echinococcosis10.4FGF23, PTH
7substance dependence10.3FGF23, PTH
8hyperostosis10.3DMP1, FGF23, PHEX
9spastic ataxia10.3DMP1, FGF23, PHEX
10gestational diabetes10.3FGF23, PTH
11capillariasis10.3FGF23, PTH
12testicular microlithiasis10.2FGF23, PTH
13prostate cancer, hereditary, x-linked 210.2FGF23, PHEX
14hypophosphatemia10.1
15hemangiopericytoma10.1
16loeys-dietz syndrome10.1FGF23, PHEX, PTH
17rickets10.1
18hyperparathyroidism10.1
19prostatitis10.1
20brugada syndrome10.0DMP1, FGF23, MEPE, PHEX
21hemangioma10.0
22paraneoplastic syndromes10.0
23peroxisome biogenesis disorder 2a10.0FGF23, MEPE, PHEX, SFRP4
24adenoiditis10.0
25overuse syndrome10.0
26prostate cancer9.9
27fanconi syndrome9.9
28neurofibromatosis9.9
29cranial nerve palsy9.9PTH, PTHLH
30adult pineal parenchymal tumor9.9PTH, PTHLH
31ptosis, strabismus, and ectopic pupils9.8PTHLH, SFRP4
32bone deterioration disease9.8FGF23, MEPE, PHEX, PTH
33sensory peripheral neuropathy9.8DMP1, FGF23, PHEX, PTH
34commensal bacterial infectious disease9.8DMP1, FGF23, PHEX, PTH
35protein-losing enteropathy9.8DMP1, FGF23, PHEX, PTH
36glycoproteinosis9.8PTH, PTHLH
37acidophil adenoma9.8PTH, PTHLH
38renal cell carcinoma9.8
39chondrosarcoma9.8
40sinusitis9.8
41fibroma9.8
42giant cell tumor9.8
43colon adenocarcinoma9.8
44cervicitis9.8
45adenocarcinoma9.8
46plasmacytoma9.8
47mesenchymal chondrosarcoma9.8
48meningitis9.8
49syndrome of inappropriate antidiuretic hormone9.8
50myopericytoma9.8

Graphical network of the top 20 diseases related to Oncogenic Osteomalacia:



Diseases related to oncogenic osteomalacia

Symptoms for Oncogenic Osteomalacia

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Drugs & Therapeutics for Oncogenic Osteomalacia

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Drugs for Oncogenic Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinPhase 2, Phase 021238916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2
MentholPhase 021842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
3phenylalanineNutraceuticalPhase 0155

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine TumorsRecruitingNCT01967537Phase 2
2Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS)Active, not recruitingNCT02304367Phase 2
3A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus SyndromeNot yet recruitingNCT02722798Phase 2
4Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets)TerminatedNCT01748812Phase 1
5Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic OsteomalaciaCompletedNCT00099762
668Ga-DOTATATE PET/CT in Oncogenic OsteomalaciaRecruitingNCT01524016Phase 0
7Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic OsteomalaciaRecruitingNCT02331966
8Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced OsteomalaciaRecruitingNCT01660308

Search NIH Clinical Center for Oncogenic Osteomalacia

Genetic Tests for Oncogenic Osteomalacia

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Anatomical Context for Oncogenic Osteomalacia

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MalaCards organs/tissues related to Oncogenic Osteomalacia:

34
Bone, Prostate, Breast, Kidney, Colon, Lung

Animal Models for Oncogenic Osteomalacia or affiliated genes

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MGI Mouse Phenotypes related to Oncogenic Osteomalacia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5DMP1, FGF23, PHEX, PTH, PTHLH
2MP:00053908.4DMP1, FGF23, MEPE, PHEX, PTH, PTHLH
3MP:00053878.1DMP1, FGF23, FGF7, MEPE, PHEX, PTH
4MP:00053678.0DMP1, FGF23, FGF7, PHEX, PTHLH, SFRP4
5MP:00053978.0DMP1, FGF23, FGF7, MEPE, PHEX, PTH
6MP:00053766.7DMP1, FGF23, FGF7, PHEX, PTH, PTHLH

Publications for Oncogenic Osteomalacia

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Articles related to Oncogenic Osteomalacia:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
177Lu-DOTATATE PRRT as promising new treatment approach in Recurrent Skull Base Phosphaturic Mesenchymal Tumor causing paraneoplastic oncogenic osteomalacia: a potential therapeutic application of PRRT beyond NET. (27634982)
2016
2
Unusual calvarial tumour-oncogenic osteomalacia. (27010121)
2016
3
A case of oncogenic osteomalacia due to occult nasal sinus tumor. (26136801)
2015
4
Oncogenic osteomalacia presenting as a crippling illness in a young man. (25263679)
2014
5
Oncogenic osteomalacia caused by phosphaturic mesenchymal tumours in the proximal and shaft of the tibia: a case report. (25163969)
2014
6
Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. (23372968)
2012
7
Oncogenic osteomalacia should be considered in hypophosphatemia, bone pain and pathological fractures. (22744630)
2012
8
Oncogenic osteomalacia: loss of hypophosphatemia might be the key to avoid misdiagnosis. (23295300)
2012
9
Comparison of whole body diffusion weighted magnetic resonance imaging and somatostatin receptor scintigraphy for oncogenic osteomalacia. (23134817)
2012
10
Advanced prostate cancer as a cause of oncogenic osteomalacia: an underdiagnosed condition. (22552356)
2012
11
Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report. (22747833)
2012
12
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
13
Oncogenic osteomalacia diagnosed by blood pool scintigraphy. (23559714)
2011
14
Oncogenic osteomalacia: A reversible metabolic bone disorder. (20924474)
2010
15
Phosphaturic mesenchymal tumour-mixed connective tissue variant without oncogenic osteomalacia. (19638551)
2009
16
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. (19441990)
2009
17
Oncogenic osteomalacia: two case reports with surprisingly different outcomes. (19125258)
2009
18
Oncogenous osteomalacia and myopericytoma of the thoracic spine: a case report. (19927092)
2009
19
Giant cell tumour of soft tissue causing oncogenic osteomalacia: report demonstrating the use of octreotide scintigraphy in tumour localization. (18068797)
2008
20
(68)Ga-DOTANOC PET/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia. (18369618)
2008
21
Oncogenic osteomalacia: induced by tumor, cured by surgery. (17307367)
2007
22
Oncogenic osteomalacia: muscular weakness and multiple fractures. (16864847)
2006
23
Oncogenic osteomalacia in a patient with hemangioma: a clinical diagnosis. (16213774)
2006
24
Case 3. Oncogenic osteomalacia associated with hemangiopericytoma localized by octreotide scan. (15908675)
2005
25
Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. (15562028)
2005
26
Oncogenic osteomalacia: diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET/CT scan for the diagnosis and follow-up in one case. (15777669)
2005
27
Foot tumor and diffuse pain: a case of oncogenic osteomalacia]. (16142164)
2005
28
Oncogenic osteomalacia--a complex dance of factors. (12711747)
2003
29
Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia. (12970268)
2003
30
A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan. (12942704)
2003
31
Oncogenic osteomalacia. (12541196)
2002
32
Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. (11581007)
2001
33
Late onset oncogenic osteomalacia-associated with neurofibromatosis type II. (11105809)
2000
34
Oncogenic osteomalacia presenting as bilateral stress fractures of the tibia. (10068075)
1999
35
Diagnostic utility of magnetic resonance imaging skeletal survey in a patient with oncogenic osteomalacia. (10495143)
1999
36
Oncogenic osteomalacia as a harbinger of recurrent osteosarcoma. (18521270)
1999
37
Oncogenic osteomalacia: is there a new phosphate regulating hormone? (9497867)
1997
38
Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. Case report. (8592237)
1996
39
Phosphaturic mesenchymal tumor, mixed connective tissue variant (oncogenic osteomalacia). (10846577)
1996
40
Oncogenic osteomalacia: evidence for a humoral phosphaturic factor. (7745010)
1995
41
Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. (8177270)
1994
42
Molecular biology of hypophosphataemic rickets and oncogenic osteomalacia. (7959677)
1994
43
Oncogenic osteomalacia: a clinicopathologic study of 17 bone lesions. (7848576)
1994
44
Oncogenic osteomalacia: imaging studies. (8387360)
1993
45
Oncogenic osteomalacia associated with metastatic prostate carcinoma: case report and review of the literature. (8409185)
1993
46
A neuroendocrine cause of oncogenic osteomalacia. (1378890)
1992
47
Oncogenic osteomalacia and renal adenomatoid dysplasia. (4039546)
1985
48
Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia. (3830474)
1985
49
Oncogenic osteomalacia. (6469602)
1984
50
Vitamin D metabolite levels in oncogenic osteomalacia. (7406381)
1980

Variations for Oncogenic Osteomalacia

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Expression for genes affiliated with Oncogenic Osteomalacia

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Search GEO for disease gene expression data for Oncogenic Osteomalacia.

Pathways for genes affiliated with Oncogenic Osteomalacia

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Pathways related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8FGF23, PTH
29.7PTH, PTHLH

GO Terms for genes affiliated with Oncogenic Osteomalacia

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Cellular components related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3FGF23, FGF7, PTH, PTHLH, SFRP4

Biological processes related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cAMP metabolic processGO:004605810.3PTH, PTHLH
2negative regulation of bone mineralizationGO:003050210.3FGF23, MEPE
3phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.3FGF23, FGF7
4phosphate ion homeostasisGO:005506210.2FGF23, SFRP4
5biomineral tissue developmentGO:00312149.9DMP1, MEPE
6positive regulation of cAMP biosynthetic processGO:00308199.9PTH, PTHLH
7hormone-mediated apoptotic signaling pathwayGO:00086289.8PTH, SSTR3
8cellular response to glucocorticoid stimulusGO:00713859.8SSTR3, SSTR5
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.7PTH, PTHLH
10cerebellum developmentGO:00215499.6SSTR1, SSTR3
11cellular response to estradiol stimulusGO:00713929.5SSTR1, SSTR3
12somatostatin signaling pathwayGO:00381709.4SSTR1, SSTR3, SSTR5
13response to starvationGO:00425949.4SSTR1, SSTR3
14skeletal system developmentGO:00015019.2MEPE, PHEX, PTH, PTHLH
15G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071878.8SSTR1, SSTR3, SSTR5
16chemical synaptic transmissionGO:00072688.5SSTR1, SSTR3, SSTR5
17cell-cell signalingGO:00072678.4PHEX, PTH, PTHLH, SSTR1, SSTR3
18negative regulation of cell proliferationGO:00082857.6PTHLH, SFRP4, SSTR1, SSTR3, SSTR5

Molecular functions related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:00514289.9PTH, PTHLH
21-phosphatidylinositol-3-kinase activityGO:00163039.7FGF23, FGF7
3somatostatin receptor activityGO:00049949.1SSTR1, SSTR3, SSTR5
4neuropeptide bindingGO:00429239.1SSTR1, SSTR3, SSTR5

Sources for Oncogenic Osteomalacia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet