MCID: ONC003
MIFTS: 40

Oncogenic Osteomalacia malady

Categories: Rare diseases, Bone diseases, Endocrine diseases

Aliases & Classifications for Oncogenic Osteomalacia

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Sources:
12diseasecard, 31ICD10 via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Oncogenic Osteomalacia:

Name: Oncogenic Osteomalacia 48 54 68
Tumor-Induced Osteomalacia 48 54
Oncogenic Hypophosphatemic Osteomalacia 54
Osteomalacia, Tumor-Induced 12
 
Oom 48
Tio 54
Oo 48

Characteristics:

Orphanet epidemiological data:

54
oncogenic osteomalacia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Orphanet54 ORPHA352540
ICD10 via Orphanet31 M83.8

Summaries for Oncogenic Osteomalacia

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Wikipedia:71 Tumor-induced osteomalacia, also known as oncogenic hypophosphatemic osteomalacia or oncogenic... more...

MalaCards based summary: Oncogenic Osteomalacia, also known as tumor-induced osteomalacia, is related to osteomalacia and jacobsen syndrome. An important gene associated with Oncogenic Osteomalacia is FGF23 (Fibroblast Growth Factor 23), and among its related pathways are Osteoblast Signaling and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, prostate and lung, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Related Diseases for Oncogenic Osteomalacia

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Diseases related to Oncogenic Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1osteomalacia10.8
2jacobsen syndrome10.5FGF23, PHEX
3familial wilms tumor 210.4FGF23, PHEX
4colorectal cancer, hereditary nonpolyposis, type 410.3DMP1, FGF23
5atelosteogenesis10.3FGF23, PHEX
6ptosis, strabismus, and ectopic pupils10.2PTHLH, SFRP4
7cystic echinococcosis10.2FGF23, PTH
8substance dependence10.2FGF23, PTH
9hyperostosis10.2DMP1, FGF23, PHEX
10spastic ataxia10.1DMP1, FGF23, PHEX
11cranial nerve palsy10.1PTH, PTHLH
12gestational diabetes10.1FGF23, PTH
13adult pineal parenchymal tumor10.1PTH, PTHLH
14capillariasis10.1FGF23, PTH
15acidophil adenoma10.1PTH, PTHLH
16testicular microlithiasis10.1FGF23, PTH
17hypophosphatemia10.0
18loeys-dietz syndrome10.0FGF23, PHEX, PTH
19chronic rheumatic pericarditis10.0PTH, PTHLH
20rickets10.0
21hyperparathyroidism10.0
22prostatitis10.0
23prostate cancer, hereditary, x-linked 29.9FGF23, PHEX
24angelucci's syndrome9.9FGF23, PTH, PTHLH
25peroxisome biogenesis disorder 2a9.9FGF23, MEPE, PHEX, SFRP4
26mild pre-eclampsia9.9FGF23, PTH, PTHLH
27toenail dystrophy, isolated9.9FGF23, PTH, PTHLH
28allergic conjunctivitis9.9FGF23, PTH, PTHLH
29t cell deficiency9.9FGF23, PTH, PTHLH
30pseudobulbar palsy9.9FGF23, PTH, PTHLH
31obesity, severe bmiq99.9PTH, PTHLH
32interval angle-closure glaucoma9.9FGF23, PTH, PTHLH
33hemangioma9.9
34paraneoplastic syndromes9.9
35brugada syndrome9.9DMP1, FGF23, MEPE, PHEX
36anal buschke-lowenstein tumor9.9PTH, PTHLH
37echolalia9.9PTH, PTHLH
38adenoiditis9.8
39overuse syndrome9.8
40prostate cancer9.8
41mixed cell type adenoma of parathyroid9.8PTH, PTHLH
42bone deterioration disease9.7FGF23, MEPE, PHEX, PTH
43astrakhan spotted fever9.7FGF23, PHEX, PTH, PTHLH
44renal cell carcinoma9.7
45chondrosarcoma9.7
46sinusitis9.7
47fibroma9.7
48giant cell tumor9.7
49colon adenocarcinoma9.7
50cervicitis9.7

Graphical network of the top 20 diseases related to Oncogenic Osteomalacia:



Diseases related to oncogenic osteomalacia

Symptoms & Phenotypes for Oncogenic Osteomalacia

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MGI Mouse Phenotypes related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.5DMP1, FGF23, PHEX, PTH, PTHLH
2MP:00053679.0DMP1, FGF23, FGF7, PHEX, PTHLH, SFRP4
3MP:00053978.4DMP1, FGF23, FGF7, MEPE, PHEX, PTH
4MP:00053878.4DMP1, FGF23, FGF7, MEPE, PHEX, PTH
5MP:00053908.2DMP1, FGF23, MEPE, PHEX, PTH, PTHLH
6MP:00053767.6DMP1, FGF23, FGF7, PHEX, PTH, PTHLH

Drugs & Therapeutics for Oncogenic Osteomalacia

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Drugs for Oncogenic Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinapprovedPhase 2, Early Phase 122938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2MitogensPhase 2, Phase 11526
3ImmunoglobulinsPhase 26045
4Immunoglobulin GPhase 2265
5AntibodiesPhase 26045
6Antibodies, MonoclonalPhase 23795
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 112767
8HormonesPhase 113979
9Calcimimetic AgentsPhase 169
10Cinacalcet HydrochloridePhase 169
11Hormone AntagonistsPhase 112778
12
MentholapprovedEarly Phase 123532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
13Pharmaceutical SolutionsEarly Phase 17793
14phenylalanineNutraceuticalEarly Phase 1158

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine TumorsRecruitingNCT01967537Phase 2
2A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus SyndromeActive, not recruitingNCT02722798Phase 2
3Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS)Active, not recruitingNCT02304367Phase 2
4Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets)TerminatedNCT01748812Phase 1
568Ga-DOTATATE PET/CT in Oncogenic OsteomalaciaUnknown statusNCT01524016Early Phase 1
6Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic OsteomalaciaCompletedNCT00099762
7Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic OsteomalaciaRecruitingNCT02331966
8Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced OsteomalaciaRecruitingNCT01660308

Search NIH Clinical Center for Oncogenic Osteomalacia

Genetic Tests for Oncogenic Osteomalacia

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Anatomical Context for Oncogenic Osteomalacia

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MalaCards organs/tissues related to Oncogenic Osteomalacia:

36
Bone, Prostate, Lung, Kidney, Colon

Publications for Oncogenic Osteomalacia

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Articles related to Oncogenic Osteomalacia:

(show top 50)    (show all 157)
idTitleAuthorsYear
1
177Lu-DOTATATE PRRT as promising new treatment approach in Recurrent Skull Base Phosphaturic Mesenchymal Tumor causing paraneoplastic oncogenic osteomalacia: a potential therapeutic application of PRRT beyond NET. (27634982)
2016
2
Unusual calvarial tumour-oncogenic osteomalacia. (27010121)
2016
3
Slow and steady wins the race": the importance of perseverance in the management of oncogenic osteomalacia. (27900654)
2016
4
A case of oncogenic osteomalacia due to occult nasal sinus tumor. (26136801)
2015
5
Oncogenic osteomalacia caused by an occult paranasal sinus tumor. (25682388)
2015
6
Phosphaturic mesenchymal tumor of the tibia with oncogenic osteomalacia in a teenager. (25721582)
2015
7
Oncogenic osteomalacia caused by occult nasal mesenchymal tumor: a monster in the cave. (26634142)
2015
8
Oncogenic osteomalacia presenting as a crippling illness in a young man. (25263679)
2014
9
Oncogenic osteomalacia caused by phosphaturic mesenchymal tumours in the proximal and shaft of the tibia: a case report. (25163969)
2014
10
Oncogenic osteomalacia induced by a sinonasal tumour: case report and review. (25090814)
2014
11
Oncogenic Osteomalacia From a Primary Phosphaturic Mesenchymal Tumor of the Toe: A Case Report. (25441266)
2014
12
Comparison of 18F-FDG and 68Ga DOTATATE PET/CT in Localization of Tumor Causing Oncogenic Osteomalacia. (24999675)
2014
13
Sinonasal glomangiopericytoma causing oncogenic osteomalacia. (24917914)
2014
14
Oncogenic osteomalacia, raised FGF-23, and renal Fanconi syndrome. (22179099)
2014
15
Oncogenic osteomalacia -- hypophosphataemic spectrum from "benignancy" to "malignancy". (23220596)
2013
16
Oncogenic osteomalacia caused by renal cell carcinoma. (24217907)
2013
17
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
18
Diagnostic Findings and Treatment in a 51-Year-Old Woman With Oncogenic Osteomalacia. (24423314)
2013
19
Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia. (23618679)
2013
20
Insufficiency fracture associated with oncogenic osteomalacia. (23319023)
2013
21
Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. (23372968)
2012
22
Oncogenic osteomalacia should be considered in hypophosphatemia, bone pain and pathological fractures. (22744630)
2012
23
Oncogenic osteomalacia: loss of hypophosphatemia might be the key to avoid misdiagnosis. (23295300)
2012
24
Comparison of whole body diffusion weighted magnetic resonance imaging and somatostatin receptor scintigraphy for oncogenic osteomalacia. (23134817)
2012
25
Advanced prostate cancer as a cause of oncogenic osteomalacia: an underdiagnosed condition. (22552356)
2012
26
Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report. (22747833)
2012
27
Anesthesia for oncogenic osteomalacia--a rare paraneoplastic syndrome. (23026174)
2012
28
Oncogenic osteomalacia from nasal cavity giant cell tumor. (22311466)
2012
29
Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia. (21739089)
2012
30
Nasal hemangiopericytoma causing oncogenic osteomalacia. (22977716)
2012
31
Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia. (22430770)
2012
32
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
33
Oncogenic osteomalacia diagnosed by blood pool scintigraphy. (23559714)
2011
34
Dual paraneoplastic syndromes: small cell lung carcinoma-related oncogenic osteomalacia, and syndrome of inappropriate antidiuretic hormone secretion: report of a case and review of the literature. (21886301)
2011
35
Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction. (21275557)
2011
36
Case 165: Oncogenic osteomalacia. (21183494)
2011
37
Oncogenic osteomalacia: A reversible metabolic bone disorder. (20924474)
2010
38
Oncogenic osteomalacia in a patient with an ethmoid sinus tumour. (20003602)
2010
39
Bilateral insufficiency fracture of the femoral head and neck in a case of oncogenic osteomalacia. (20595128)
2010
40
Interesting image. The search for primary tumor in a patient with oncogenic osteomalacia: F-18 FDG PET resolves the conundrum. (20940555)
2010
41
The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels. (20458578)
2010
42
Oncogenic osteomalacia: Problems in diagnosis and long-term management. (20924490)
2010
43
Photoclinic. Oncogenic osteomalacia. (20433234)
2010
44
Multiple phosphaturic mesenchymal tumors associated with oncogenic osteomalacia: case report and review of the literature. (20556724)
2010
45
Phosphaturic mesenchymal tumour-mixed connective tissue variant without oncogenic osteomalacia. (19638551)
2009
46
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. (19441990)
2009
47
Oncogenic osteomalacia: two case reports with surprisingly different outcomes. (19125258)
2009
48
Oncogenous osteomalacia and myopericytoma of the thoracic spine: a case report. (19927092)
2009
49
Somatostatin receptor expression in an epitheloid hemangioma causing oncogenic osteomalacia. (19789203)
2009
50
Oncogenic osteomalacia from pterygopalatine fossa mass. (19250593)
2009

Variations for Oncogenic Osteomalacia

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Expression for genes affiliated with Oncogenic Osteomalacia

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Search GEO for disease gene expression data for Oncogenic Osteomalacia.

Pathways for genes affiliated with Oncogenic Osteomalacia

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Pathways related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7FGF23, PTH
29.7PTH, PTHLH

GO Terms for genes affiliated with Oncogenic Osteomalacia

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Cellular components related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.4FGF23, FGF7, PTH, PTHLH, SFRP4

Biological processes related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:005506210.5FGF23, SFRP4
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:000718910.4PTH, PTHLH
3cAMP metabolic processGO:004605810.4PTH, PTHLH
4negative regulation of bone mineralizationGO:003050210.3FGF23, MEPE
5biomineral tissue developmentGO:003121410.3DMP1, MEPE
6positive regulation of cAMP biosynthetic processGO:003081910.3PTH, PTHLH
7phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.2FGF23, FGF7
8cellular response to glucocorticoid stimulusGO:00713859.9SSTR3, SSTR5
9hormone-mediated apoptotic signaling pathwayGO:00086289.9PTH, SSTR3
10cellular response to estradiol stimulusGO:00713929.8SSTR1, SSTR3
11cerebellum developmentGO:00215499.8SSTR1, SSTR3
12response to starvationGO:00425949.7SSTR1, SSTR3
13chemical synaptic transmissionGO:00072689.4SSTR1, SSTR3, SSTR5
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.4SSTR1, SSTR3, SSTR5
15skeletal system developmentGO:00015019.0MEPE, PHEX, PTH, PTHLH
16cell-cell signalingGO:00072678.8PHEX, PTH, PTHLH, SSTR1, SSTR3
17somatostatin signaling pathwayGO:00381708.7SSTR1, SSTR3, SSTR5
18negative regulation of cell proliferationGO:00082858.7PTHLH, SFRP4, SSTR1, SSTR3, SSTR5

Molecular functions related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.0FGF23, FGF7
2peptide hormone receptor bindingGO:00514289.8PTH, PTHLH
3neuropeptide bindingGO:00429239.0SSTR1, SSTR3, SSTR5
4somatostatin receptor activityGO:00049948.7SSTR1, SSTR3, SSTR5

Sources for Oncogenic Osteomalacia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet