OO
MCID: ONC003
MIFTS: 41

Oncogenic Osteomalacia (OO) malady

Categories: Rare diseases, Bone diseases, Endocrine diseases

Aliases & Classifications for Oncogenic Osteomalacia

Aliases & Descriptions for Oncogenic Osteomalacia:

Name: Oncogenic Osteomalacia 50 56 69
Tumor-Induced Osteomalacia 50 56
Oncogenic Hypophosphatemic Osteomalacia 56
Osteomalacia, Tumor-Induced 13
Oom 50
Tio 56
Oo 50

Characteristics:

Orphanet epidemiological data:

56
oncogenic osteomalacia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 56 ORPHA352540
ICD10 via Orphanet 34 M83.8

Summaries for Oncogenic Osteomalacia

MalaCards based summary : Oncogenic Osteomalacia, also known as tumor-induced osteomalacia, is related to osteomalacia and wiedemann-steiner syndrome. An important gene associated with Oncogenic Osteomalacia is FGF23 (Fibroblast Growth Factor 23), and among its related pathways/superpathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Osteoblast Signaling. The drugs Somatostatin and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and lung, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 71 Tumor-induced osteomalacia, also known as oncogenic hypophosphatemic osteomalacia or oncogenic... more...

Related Diseases for Oncogenic Osteomalacia

Diseases related to Oncogenic Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 osteomalacia 10.8
2 wiedemann-steiner syndrome 10.3 FGF23 PHEX
3 familial atrial fibrillation 10.2 FGF23 PHEX
4 progressive locomotor ataxia 10.2 FGF23 PTHLH
5 feigenbaum bergeron richardson syndrome 10.2 FGF23 PHEX
6 ventricular tachycardia, catecholaminergic polymorphic, 3 10.2 DMP1 FGF23
7 maroteaux stanescu cousin syndrome 10.1 FGF23 PHEX PTHLH
8 pterygium, antecubital 10.1 PTHLH SFRP4
9 orbit lymphoma 10.1 FGF23 PTH
10 lymphangioleiomyomatosis 10.1 DMP1 FGF23 PHEX
11 acute maxillary sinusitis 10.1 DMP1 FGF23 PHEX
12 toxicodendron dermatitis 10.1 PTH PTHLH
13 x-linked hereditary ataxia 10.1 DMP1 FGF23 PHEX
14 malignant granular cell myoblastoma 10.1 PTH PTHLH
15 prostate cancer, hereditary, x-linked 2 10.1 DMP1 FGF23 PHEX
16 joubert syndrome 9 10.1 FGF23 PTH
17 mixed germ cell cancer 10.1 PTH PTHLH
18 waardenburg syndrome, type 4b 10.1 PTH PTHLH
19 prediabetes syndrome 10.1 FGF23 PTH
20 strabismus 10.0 PTH PTHLH
21 peroxisome biogenesis disorder 2b 10.0 FGF23 MEPE PHEX SFRP4
22 toenail dystrophy, isolated 10.0 FGF23 PTH PTHLH
23 hypophosphatemia 10.0
24 opioid abuse 10.0 FGF23 PTH PTHLH
25 parathyroid carcinoma 10.0 FGF23 PTH PTHLH
26 obesity, severe bmiq9 10.0 PTH PTHLH
27 parathyroid gland disease 10.0 FGF23 PTH PTHLH
28 impotence 10.0 PTH PTHLH
29 ovarian endometrioid cystadenoma 10.0 PTH PTHLH
30 pes anserinus tendinitis or bursitis 10.0 FGF23 PTH
31 rickets 10.0
32 hyperparathyroidism 10.0
33 prostatitis 10.0
34 ischemic bone disease 9.9 FGF23 MEPE PHEX PTH
35 indian tick typhus 9.9 FGF23 PHEX PTH PTHLH
36 subserous uterine fibroid 9.9 FGF23 PHEX PTH PTHLH
37 hemangioma 9.9
38 paraneoplastic syndromes 9.9
39 gastric antral vascular ectasia 9.9 DMP1 FGF23 PHEX PTH
40 allergic urticaria 9.9 DMP1 FGF23 PHEX PTH
41 intracranial thrombosis 9.9 PTH PTHLH
42 carnitine deficiency, systemic primary 9.9 FGF23 MEPE PTH PTHLH
43 adenoiditis 9.8
44 overuse syndrome 9.8
45 prostate cancer 9.8
46 neurofibromatosis 9.8
47 fanconi syndrome 9.8
48 coffin-lowry syndrome 9.7 DMP1 FGF23 PHEX PTH SFRP4
49 adenocarcinoma 9.7
50 renal cell carcinoma 9.7

Graphical network of the top 20 diseases related to Oncogenic Osteomalacia:



Diseases related to Oncogenic Osteomalacia

Symptoms & Phenotypes for Oncogenic Osteomalacia

MGI Mouse Phenotypes related to Oncogenic Osteomalacia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.01 DMP1 FGF23 FGF7 PHEX PTH PTHLH
2 hematopoietic system MP:0005397 9.97 DMP1 FGF23 FGF7 MEPE PHEX PTH
3 homeostasis/metabolism MP:0005376 9.97 DMP1 FGF23 FGF7 PHEX PTH PTHLH
4 immune system MP:0005387 9.86 DMP1 FGF23 FGF7 MEPE PHEX PTH
5 limbs/digits/tail MP:0005371 9.63 DMP1 FGF23 PHEX PTH PTHLH SFRP4
6 renal/urinary system MP:0005367 9.43 DMP1 FGF23 FGF7 PHEX PTHLH SFRP4
7 skeleton MP:0005390 9.23 DMP1 FGF23 FGF7 MEPE PHEX PTH

Drugs & Therapeutics for Oncogenic Osteomalacia

Drugs for Oncogenic Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved Phase 2,Early Phase 1 38916-34-6, 51110-01-1 53481605
2 Mitogens Phase 2,Phase 1
3 Antibodies Phase 2
4 Antibodies, Monoclonal Phase 2
5 Immunoglobulin G Phase 2
6 Immunoglobulins Phase 2
7 Calcimimetic Agents Phase 1
8 Cinacalcet Hydrochloride Phase 1
9 Hormone Antagonists Phase 1
10 Hormones Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
12
Menthol Approved Early Phase 1 2216-51-5 16666
13 Pharmaceutical Solutions Early Phase 1
14 phenylalanine Nutraceutical Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Recruiting NCT01967537 Phase 2
2 A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome Active, not recruiting NCT02722798 Phase 2
3 Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS) Active, not recruiting NCT02304367 Phase 2
4 Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Terminated NCT01748812 Phase 1
5 Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia Unknown status NCT02331966
6 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
7 68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia Recruiting NCT01524016 Early Phase 1
8 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Recruiting NCT01660308

Search NIH Clinical Center for Oncogenic Osteomalacia

Genetic Tests for Oncogenic Osteomalacia

Anatomical Context for Oncogenic Osteomalacia

MalaCards organs/tissues related to Oncogenic Osteomalacia:

39
Bone, Prostate, Lung, Kidney, Colon, Breast

Publications for Oncogenic Osteomalacia

Articles related to Oncogenic Osteomalacia:

(show top 50) (show all 157)
id Title Authors Year
1
Unusual calvarial tumour-oncogenic osteomalacia. ( 27010121 )
2016
2
177Lu-DOTATATE PRRT as promising new treatment approach in Recurrent Skull Base Phosphaturic Mesenchymal Tumor causing paraneoplastic oncogenic osteomalacia: a potential therapeutic application of PRRT beyond NET. ( 27634982 )
2016
3
"Slow and steady wins the race": the importance of perseverance in the management of oncogenic osteomalacia. ( 27900654 )
2016
4
Oncogenic osteomalacia caused by an occult paranasal sinus tumor. ( 25682388 )
2015
5
Oncogenic osteomalacia caused by occult nasal mesenchymal tumor: a monster in the cave. ( 26634142 )
2015
6
Phosphaturic mesenchymal tumor of the tibia with oncogenic osteomalacia in a teenager. ( 25721582 )
2015
7
A case of oncogenic osteomalacia due to occult nasal sinus tumor. ( 26136801 )
2015
8
Oncogenic osteomalacia, raised FGF-23, and renal Fanconi syndrome. ( 22179099 )
2014
9
Sinonasal glomangiopericytoma causing oncogenic osteomalacia. ( 24917914 )
2014
10
Oncogenic Osteomalacia From a Primary Phosphaturic Mesenchymal Tumor of the Toe: A Case Report. ( 25441266 )
2014
11
Oncogenic osteomalacia caused by phosphaturic mesenchymal tumours in the proximal and shaft of the tibia: a case report. ( 25163969 )
2014
12
Comparison of 18F-FDG and 68Ga DOTATATE PET/CT in Localization of Tumor Causing Oncogenic Osteomalacia. ( 24999675 )
2014
13
Oncogenic osteomalacia presenting as a crippling illness in a young man. ( 25263679 )
2014
14
Oncogenic osteomalacia induced by a sinonasal tumour: case report and review. ( 25090814 )
2014
15
Insufficiency fracture associated with oncogenic osteomalacia. ( 23319023 )
2013
16
Oncogenic osteomalacia caused by renal cell carcinoma. ( 24217907 )
2013
17
Diagnostic Findings and Treatment in a 51-Year-Old Woman With Oncogenic Osteomalacia. ( 24423314 )
2013
18
Oncogenic osteomalacia -- hypophosphataemic spectrum from "benignancy" to "malignancy". ( 23220596 )
2013
19
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. ( 23393166 )
2013
20
Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia. ( 23618679 )
2013
21
Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia. ( 21739089 )
2012
22
Oncogenic osteomalacia: loss of hypophosphatemia might be the key to avoid misdiagnosis. ( 23295300 )
2012
23
Anesthesia for oncogenic osteomalacia--a rare paraneoplastic syndrome. ( 23026174 )
2012
24
Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia. ( 22430770 )
2012
25
Oncogenic osteomalacia should be considered in hypophosphatemia, bone pain and pathological fractures. ( 22744630 )
2012
26
Advanced prostate cancer as a cause of oncogenic osteomalacia: an underdiagnosed condition. ( 22552356 )
2012
27
Oncogenic osteomalacia associated with mesenchymal tumor in the middle cranial fossa: a case report. ( 22747833 )
2012
28
Nasal hemangiopericytoma causing oncogenic osteomalacia. ( 22977716 )
2012
29
Oncogenic osteomalacia from nasal cavity giant cell tumor. ( 22311466 )
2012
30
Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. ( 23372968 )
2012
31
Comparison of whole body diffusion weighted magnetic resonance imaging and somatostatin receptor scintigraphy for oncogenic osteomalacia. ( 23134817 )
2012
32
Dual paraneoplastic syndromes: small cell lung carcinoma-related oncogenic osteomalacia, and syndrome of inappropriate antidiuretic hormone secretion: report of a case and review of the literature. ( 21886301 )
2011
33
Oncogenic osteomalacia diagnosed by blood pool scintigraphy. ( 23559714 )
2011
34
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. ( 22461817 )
2011
35
Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction. ( 21275557 )
2011
36
Case 165: Oncogenic osteomalacia. ( 21183494 )
2011
37
Oncogenic osteomalacia: A reversible metabolic bone disorder. ( 20924474 )
2010
38
Interesting image. The search for primary tumor in a patient with oncogenic osteomalacia: F-18 FDG PET resolves the conundrum. ( 20940555 )
2010
39
Oncogenic osteomalacia: Problems in diagnosis and long-term management. ( 20924490 )
2010
40
Multiple phosphaturic mesenchymal tumors associated with oncogenic osteomalacia: case report and review of the literature. ( 20556724 )
2010
41
Bilateral insufficiency fracture of the femoral head and neck in a case of oncogenic osteomalacia. ( 20595128 )
2010
42
The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels. ( 20458578 )
2010
43
Photoclinic. Oncogenic osteomalacia. ( 20433234 )
2010
44
Oncogenic osteomalacia in a patient with an ethmoid sinus tumour. ( 20003602 )
2010
45
Oncogenous osteomalacia. ( 19841566 )
2009
46
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. ( 19441990 )
2009
47
Oncogenic osteomalacia: two case reports with surprisingly different outcomes. ( 19125258 )
2009
48
Somatostatin receptor expression in an epitheloid hemangioma causing oncogenic osteomalacia. ( 19789203 )
2009
49
Oncogenic osteomalacia associated with phosphaturic mesenchymal tumour, mixed connective tissue type of the knee. ( 20200786 )
2009
50
Oncogenic osteomalacia from pterygopalatine fossa mass. ( 19250593 )
2009

Variations for Oncogenic Osteomalacia

Expression for Oncogenic Osteomalacia

Search GEO for disease gene expression data for Oncogenic Osteomalacia.

Pathways for Oncogenic Osteomalacia

Pathways related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.55 PTH PTHLH
2 9.77 FGF23 PTH

GO Terms for Oncogenic Osteomalacia

Cellular components related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 DMP1 FGF23 FGF7 MEPE PTH PTHLH

Biological processes related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.75 DMP1 FGF23 MEPE
2 negative regulation of cell proliferation GO:0008285 9.72 PTHLH SFRP4 SSTR1 SSTR3 SSTR5
3 cerebellum development GO:0021549 9.61 SSTR1 SSTR3
4 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.61 SSTR1 SSTR3 SSTR5
5 positive regulation of cAMP biosynthetic process GO:0030819 9.6 PTH PTHLH
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.59 PTH PTHLH
7 cellular response to estradiol stimulus GO:0071392 9.58 SSTR1 SSTR3
8 response to starvation GO:0042594 9.57 SSTR1 SSTR3
9 response to vitamin D GO:0033280 9.56 PHEX PTH
10 skeletal system development GO:0001501 9.56 MEPE PHEX PTH PTHLH
11 cellular response to glucocorticoid stimulus GO:0071385 9.55 SSTR3 SSTR5
12 negative regulation of chondrocyte differentiation GO:0032331 9.54 PTH PTHLH
13 negative regulation of bone mineralization GO:0030502 9.52 FGF23 MEPE
14 cellular response to vitamin D GO:0071305 9.51 FGF23 PHEX
15 cellular response to parathyroid hormone stimulus GO:0071374 9.49 FGF23 PHEX
16 phosphate ion homeostasis GO:0055062 9.48 FGF23 SFRP4
17 hormone-mediated apoptotic signaling pathway GO:0008628 9.46 PTH SSTR3
18 cAMP metabolic process GO:0046058 9.4 PTH PTHLH
19 response to sodium phosphate GO:1904383 9.37 FGF23 PHEX
20 cell-cell signaling GO:0007267 9.35 PHEX PTH PTHLH SSTR1 SSTR3
21 biomineral tissue development GO:0031214 9.33 DMP1 MEPE PHEX
22 somatostatin signaling pathway GO:0038170 8.8 SSTR1 SSTR3 SSTR5

Molecular functions related to Oncogenic Osteomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 1-phosphatidylinositol-3-kinase activity GO:0016303 9.32 FGF23 FGF7
2 fibroblast growth factor receptor binding GO:0005104 9.26 FGF23 FGF7
3 peptide hormone receptor binding GO:0051428 9.16 PTH PTHLH
4 neuropeptide binding GO:0042923 9.13 SSTR1 SSTR3 SSTR5
5 somatostatin receptor activity GO:0004994 8.8 SSTR1 SSTR3 SSTR5

Sources for Oncogenic Osteomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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