Oophoritis malady

Wikipedia: Oophoritis is an inflammation of the ovaries.⁴⁴ more...

MalaCards: Oophoritis is related to agammaglobulinemia and fragile x-associated primary ovarian insufficiency. An important gene associated with Oophoritis is C8G (complement component 8, gamma polypeptide), and among its related pathways is Primary immunodeficiency. Affiliated tissues include ovary, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

oophoritis 8 43

Diseases related to oophoritis by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	agammaglobulinemia	12.6	CD4, IGLL1
2	fragile x-associated primary ovarian insufficiency	12.0	ZP1, ZP3, ZP4
3	diphtheria	11.7	ZP1, ZP3, CD4
4	infertility	10.8	NOBOX, PZP, ZP1, ZP2, ZP3, ZP4
5	chronic salpingo-oophoritis	8.5
6	salpingo-oophoritis	8.5
7	acute salpingo-oophoritis	8.2
8	autoimmune oophoritis	7.1
9	tuberculous oophoritis	7.1
10	salpingitis	5.6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to oophoritis:

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MGI Mouse Phenotypes related to oophoritis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.1	NOBOX, PZP, ZP1, ZP2, ZP3
2	reproductive system phenotype	MP:0005389	7.0	NOBOX, ZP3, ZP2, ZP1, PZP, NLRP5

Genes related to oophoritis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	C8G	complement component 8, gamma polypeptide	11.0
2	ZP1	zona pellucida glycoprotein 1 (sperm receptor)	11.0	Disorders
3	IGLL1	immunoglobulin lambda-like polypeptide 1	11.0
4	ZP4	zona pellucida glycoprotein 4	11.0	Disorders
5	NOBOX	NOBOX oogenesis homeobox	11.0	Disorders
6	ZP2	zona pellucida glycoprotein 2 (sperm receptor)	11.0	Disorders
7	PZP	pregnancy-zone protein	11.0
8	ZP3	zona pellucida glycoprotein 3 (sperm receptor)	11.0	Disorders
9	NLRP5	NLR family, pyrin domain containing 5	11.0
10	CD4	CD4 molecule	11.0	Disorders

Pathways related to oophoritis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Primary immunodeficiency20	9.6	CD4, IGLL1

Cellular components related to oophoritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	multivesicular body	GO:005771	9.4	ZP2, ZP3
2	secretory granule	GO:030141	8.8	ZP1, ZP2, ZP3
3	proteinaceous extracellular matrix	GO:005578	8.6	ZP1, ZP2, ZP3, ZP4

Biological processes related to oophoritis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of binding of sperm to zona pellucida	GO:2000360	9.6	ZP3, ZP4
2	positive regulation of humoral immune response	GO:002922	9.6	ZP3, ZP4
3	positive regulation of acrosome reaction	GO:2000344	9.5	ZP4, ZP3
4	positive regulation of T cell proliferation	GO:042102	9.5	ZP4, ZP3
5	manganese ion transport	GO:006828	9.4	ZP3, ZP2
6	protein kinase C signaling cascade	GO:070528	9.4	ZP4, ZP3
7	positive regulation of protein kinase activity	GO:045860	9.1	CD4, ZP4, ZP3
8	binding of sperm to zona pellucida	GO:007339	9.1	ZP2, ZP3

Molecular functions related to oophoritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:015026	9.5	CD4, ZP2
2	acrosin binding	GO:032190	8.7	ZP2, ZP3, ZP4