MCID: OPN001
MIFTS: 59

Open-Angle Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories

Summaries for Open-Angle Glaucoma

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Disease Ontology:10 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

MalaCards based summary: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to ocular hypertension and primary angle-closure glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Estrogen metabolism and Degradation of the extracellular matrix. The drugs epinephrine hydrochloride and epinephrine and the compounds pyrene and 1-hydroxypyrene have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 40NCIt, 27ICD10
See all sources

Open-Angle Glaucoma, Aliases & Descriptions:

Name: Open-Angle Glaucoma 10
Open-Angle Glaucoma, Unspecified 62
Wide-Angle Glaucoma Nos 10
Glaucoma, Open-Angle 62
 
Pigmentary Glaucoma 10
Glaucoma Open-Angle 45
Open Angle Glaucoma 10
Glaucoma Simplex 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology10 DOID:1067
MeSH35 D005902
NCIt40 C34641
ICD1027 H40.1

Related Diseases for Open-Angle Glaucoma

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Diseases in the Open-Angle Glaucoma family:

Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1a, Primary Open Angle Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma, Primary Open Angle, Juvenile-Onset, 2 Glaucoma 1, Open Angle, 1o

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension32.0MYOC, OPTN
2primary angle-closure glaucoma31.4MYOC
3glaucoma 1a, primary open angle31.1MYOC, OPTN
4exfoliation syndrome31.1ELN, LOXL1
5glaucoma 1, open angle, e31.1CYP1B1, OPTN, GSTM1, ELN, ASB10, MYOC
6blindness30.9MYOC, WDR36, OPTN
7primary congenital glaucoma30.9CYP1B1
8retinitis11.0
9cataract10.8
10myopia10.8
11low tension glaucoma10.7
12endotheliitis10.6
13ocular hypotension10.6
14residual stage of open angle glaucoma10.5
15choroiditis10.5
16dementia10.5
17neuropathy10.5
18glaucoma, normal tension10.5
19retinal vein occlusion10.5
20senile cataract10.5
21nail-patella syndrome10.4
22glaucoma 1, open angle, p10.4
23pigment dispersion syndrome10.4
24pulmonary hypertension10.4
25central retinal vein occlusion10.4
26kearns-sayre syndrome10.4
27glaucomatocyclitic crisis10.4
28cerebritis10.4
29thyroiditis10.4
30nevus of ota10.4
31glaucoma 1, open angle, g10.2
32glaucoma 1, open angle, m10.2
33marfan syndrome10.2
34migraine10.2
35glaucoma 1, open angle, 1o10.2
36atherosclerosis10.2
37ischemic optic neuropathy10.2
38keratoconus10.2
39keratopathy10.2
40vascular dementia10.2
41neovascular glaucoma10.2
42juvenile glaucoma10.2
43waardenburg's syndrome10.2
44exophthalmos10.2
45degenerative myopia10.2
46conjunctivochalasis10.2
47neuroretinitis10.2
48cycloplegia10.2
49lens subluxation10.2
50anisometropia10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Symptoms for Open-Angle Glaucoma

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Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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MalaCards organs/tissues related to Open-Angle Glaucoma:

33
Eye, Testes, Endothelial, Cortex, Brain, Retina, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Publications for Open-Angle Glaucoma

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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1079)
idTitleAuthorsYear
1
Correction: Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study. (25849906)
2015
2
Efficacy and safety of SNJ-1656 in primary open-angle glaucoma or ocular hypertension. (25783615)
2015
3
Risk factors for predicting visual field progression in Chinese patients with primary open-angle glaucoma: A retrospective study. (25819708)
2015
4
Genetic Association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the Endophenotypes of Primary Open Angle Glaucoma in Indian Population. (25798827)
2015
5
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
6
Open-angle glaucoma surgery: the current standing. (25295896)
2014
7
Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma. (25237590)
2014
8
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
9
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
10
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
11
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
12
Selective Laser Trabeculoplasty versus Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. (24367649)
2013
13
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
14
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
15
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
16
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
17
The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family. (23886590)
2013
18
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
19
Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. (23603758)
2013
20
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
21
Ocular rigidity, outflow facility, ocular pulse amplitude, and pulsatile ocular blood flow in open-angle glaucoma: a manometric study. (23761082)
2013
22
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension. (24180628)
2013
23
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
24
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
25
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
26
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
27
Primary open-angle glaucoma: everyone's business. (23520411)
2012
28
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
29
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
30
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
31
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
32
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
33
Five-year, multicenter safety study of fixed-combination latanoprost/timolol (Xalacom) for open-angle glaucoma and ocular hypertension. (20520568)
2011
34
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
35
Laser trabeculoplasty in the treatment of open-angle glaucoma. (21633246)
2011
36
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
37
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
38
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
39
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
40
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
41
Primary open-angle glaucoma. (19535810)
2009
42
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
43
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
44
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
45
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
46
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
47
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. (15216404)
2004
48
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
49
Molecular genetics of open-angle glaucoma, moving from gene localization to predictive testing. (10168351)
1997
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GSTM1, CYP1B1
2
Show member pathways
8.8ELN, LOXL1, TGFB2
3
Show member pathways
8.8ELN, LOXL1, TGFB2

Compounds for genes affiliated with Open-Angle Glaucoma

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Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1pyrene4510.1GSTM1, CYP1B1
21-hydroxypyrene4510.1GSTM1, CYP1B1
3phip4510.1CYP1B1, GSTM1
4cotinine45 2611.1CYP1B1, GSTM1
5aflatoxin b145 2611.1GSTM1, CYP1B1
6hydrocarbons4510.0GSTM1, CYP1B1
7benzene4510.0GSTM1, ELN
8deoxypyridinoline459.9ELN, TGFB2
9quinone45 2610.9CYP1B1, GSTM1
10tcdd459.9TGFB2, CYP1B1
11alginate459.9TGFB2, ELN
12epoxide459.8GSTM1, CYP1B1
13glycosaminoglycan459.8TGFB2, MYOC, ELN
14hyaluronic acid45 2610.8TGFB2, MYOC, ELN
15oxaliplatin45 51 1311.7GSTM1, CYP1B1
16valine459.7CYP1B1, ELN, GSTM1
17betacarotene459.7GSTM1, ELN
18benzo(a)pyrene459.7GSTM1, TGFB2, CYP1B1
19p003459.7GSTM1, TGFB2, CYP1B1
20ozone459.6GSTM1, ELN, TGFB2
21vitamin a45 26 1311.6GSTM1, ELN, TGFB2
225fluorouracil459.6CYP1B1, TGFB2, GSTM1
23n acetylcysteine459.6ELN, TGFB2, CYP1B1
24vitamin d459.5GSTM1, ELN, TGFB2
25doxycycline45 1310.5ELN, CYP1B1
26cycloheximide459.4ELN, MYOC, TGFB2, CYP1B1
27ascorbic acid45 2610.4TGFB2, MYOC, ELN, GSTM1
28testosterone45 61 26 1312.3GSTM1, ELN, TGFB2, CYP1B1
29genistein45 30 61 3 26 1314.2CYP1B1, TGFB2, ELN
30dexamethasone45 51 30 1312.1CYP1B1, TGFB2, MYOC, ELN, OPTN
31arginine459.1MYOC, ELN, NTF4, GSTM1
32estrogen459.1GSTM1, ELN, TGFB2, CYP1B1
33cysteine459.0TGFB2, MYOC, ELN, GSTM1
34glutamate458.9CYP1B1, TGFB2, ELN, NTF4
35retinoic acid45 269.8CYP1B1, TGFB2, ELN, NTF4

GO Terms for genes affiliated with Open-Angle Glaucoma

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Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.9LOXL1, MYOC, TGFB2

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.8MYOC, TGFB2
2blood vessel remodelingGO:00019749.5ELN, TGFB2
3extracellular matrix organizationGO:00301988.5ELN, LOXL1, TGFB2

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Open-Angle Glaucoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet