MCID: OPN001
MIFTS: 57

Open-Angle Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories

Summaries for Open-Angle Glaucoma

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48OMIM, 34MalaCards
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MalaCards: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to primary open angle glaucoma and glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Estrogen metabolism and Degradation of the extracellular matrix. The drugs epinephrine hydrochloride and epinephrine and the compounds pyrene and 1-hydroxypyrene have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Description from OMIM:48 609887,137750,613100

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


Aliases & Descriptions:

open-angle glaucoma 9
open-angle glaucoma, unspecified 9
unspecified open-angle glaucoma 9
wide-angle glaucoma nos 9
open-angle glaucoma nos 9
glaucoma, open-angle 63
open angle glaucoma 9
pigmentary glaucoma 9
glaucoma open-angle 46
glaucoma simplex 9


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Disease Ontology9 DOID:1067
MeSH36 D005902
NCIt41 C34641
ICD1026 H40.1

Related Diseases for Open-Angle Glaucoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

Primary Open Angle Glaucoma open-angle glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1primary open angle glaucoma32.3CYP1B1, OPTN, GSTM1, ELN, ASB10, MYOC
2glaucoma32.2OPTN, WDR36, NTF4, ELN, LOXL1, MYOC
3ocular hypertension32.0MYOC, OPTN
4primary angle-closure glaucoma31.4MYOC
5primary open angle glaucoma juvenile onset 131.1MYOC, OPTN
6exfoliation syndrome31.1ELN, LOXL1
7blindness30.9MYOC, WDR36, OPTN
8primary congenital glaucoma30.8CYP1B1
9hypertension11.3
10retinitis10.9
11cataract10.8
12myopia10.7
13low tension glaucoma10.7
14endotheliitis10.6
15residual stage of open angle glaucoma10.5
16neuropathy10.5
17ocular hypotension10.5
18glaucoma 1, open angle, e10.5
19choroiditis10.4
20retinal vein occlusion10.4
21senile cataract10.4
22nail-patella syndrome10.4
23central retinal vein occlusion10.4
24kearns-sayre syndrome10.4
25glaucomatocyclitic crisis10.4
26alzheimer's disease10.4
27primary pulmonary hypertension10.4
28dementia10.4
29diabetic retinopathy10.4
30thyroiditis10.4
31nevus of ota10.4
32age related macular degeneration10.2
33ischemic retinopathy10.2
34neovascular glaucoma10.2
35juvenile glaucoma10.2
36waardenburg's syndrome10.2
37exophthalmos10.2
38degenerative myopia10.2
39neuroretinitis10.2
40cycloplegia10.2
41lens subluxation10.2
42anisometropia10.2
43cerebritis10.2
44bullous keratopathy10.2
45retinal lattice degeneration10.2
46exudative vitreoretinopathy10.2
47ochronosis10.2
48marfan syndrome10.2
49astigmatism10.2
50atherosclerosis10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Symptoms for Open-Angle Glaucoma

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Sources:
48OMIM
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Clinical features from OMIM:

609887,137750,613100

Drugs & Therapeutics for Open-Angle Glaucoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Open-Angle Glaucoma:

34
Eye, Testes, Endothelial, Brain, Cortex, Retina, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Publications for Open-Angle Glaucoma

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Sources:
53PubMed
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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1012)
idTitleAuthorsYear
1
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
2
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
3
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
4
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
5
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
6
Selective Laser Trabeculoplasty versus Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. (24367649)
2013
7
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
8
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
9
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
10
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
11
The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family. (23886590)
2013
12
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
13
Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. (23603758)
2013
14
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
15
Ocular rigidity, outflow facility, ocular pulse amplitude, and pulsatile ocular blood flow in open-angle glaucoma: a manometric study. (23761082)
2013
16
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension. (24180628)
2013
17
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
18
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
19
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
20
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
21
Primary open-angle glaucoma: everyone's business. (23520411)
2012
22
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
23
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
24
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
25
GSTM1 polymorphism in patients with primary open-angle glaucoma. (23079819)
2012
26
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
27
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
28
Five-year, multicenter safety study of fixed-combination latanoprost/timolol (Xalacom) for open-angle glaucoma and ocular hypertension. (20520568)
2011
29
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
30
Laser trabeculoplasty in the treatment of open-angle glaucoma. (21633246)
2011
31
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. (21743018)
2011
32
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
33
Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study. (20420586)
2010
34
Effectiveness of dorzolamidea89timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study. (20874498)
2010
35
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
36
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
37
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
38
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
39
Primary open-angle glaucoma. (19535810)
2009
40
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
41
Comparative biometric study between plateau iris configuration and primary open angle glaucoma with narrow angle. (19668957)
2009
42
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
43
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
44
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
45
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
46
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. (15216404)
2004
47
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
48
Molecular genetics of open-angle glaucoma, moving from gene localization to predictive testing. (10168351)
1997
49
Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. (2021590)
1991
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome
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Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GSTM1, CYP1B1
2
Show member pathways
8.8ELN, LOXL1, TGFB2
3
Show member pathways
8.8ELN, LOXL1, TGFB2

Compounds for genes affiliated with Open-Angle Glaucoma

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1pyrene4610.1GSTM1, CYP1B1
21-hydroxypyrene4610.1GSTM1, CYP1B1
3phip4610.1CYP1B1, GSTM1
4cotinine46 2511.1CYP1B1, GSTM1
5aflatoxin b146 2511.1GSTM1, CYP1B1
6hydrocarbons4610.0GSTM1, CYP1B1
7benzene4610.0GSTM1, ELN
8deoxypyridinoline469.9ELN, TGFB2
9quinone46 2510.9CYP1B1, GSTM1
10tcdd469.9TGFB2, CYP1B1
11alginate469.9TGFB2, ELN
12epoxide469.8GSTM1, CYP1B1
13glycosaminoglycan469.8TGFB2, MYOC, ELN
14hyaluronic acid46 2510.8TGFB2, MYOC, ELN
15oxaliplatin46 52 1211.7GSTM1, CYP1B1
16valine469.7CYP1B1, ELN, GSTM1
17betacarotene469.7GSTM1, ELN
18benzo(a)pyrene469.7GSTM1, TGFB2, CYP1B1
19p003469.7GSTM1, TGFB2, CYP1B1
20ozone469.6GSTM1, ELN, TGFB2
21vitamin a46 25 1211.6GSTM1, ELN, TGFB2
225fluorouracil469.6CYP1B1, TGFB2, GSTM1
23n acetylcysteine469.6ELN, TGFB2, CYP1B1
24vitamin d469.5GSTM1, ELN, TGFB2
25doxycycline46 1210.5ELN, CYP1B1
26cycloheximide469.4ELN, MYOC, TGFB2, CYP1B1
27ascorbic acid46 2510.4TGFB2, MYOC, ELN, GSTM1
28testosterone46 62 25 1212.3GSTM1, ELN, TGFB2, CYP1B1
29genistein46 30 62 3 25 1214.2CYP1B1, TGFB2, ELN
30dexamethasone46 52 30 1212.1CYP1B1, TGFB2, MYOC, ELN, OPTN
31arginine469.1MYOC, ELN, NTF4, GSTM1
32estrogen469.1GSTM1, ELN, TGFB2, CYP1B1
33cysteine469.0TGFB2, MYOC, ELN, GSTM1
34glutamate468.9CYP1B1, TGFB2, ELN, NTF4
35retinoic acid46 259.8CYP1B1, TGFB2, ELN, NTF4

GO Terms for genes affiliated with Open-Angle Glaucoma

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Sources:
17Gene Ontology
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Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.9LOXL1, MYOC, TGFB2

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.8MYOC, TGFB2
2blood vessel remodelingGO:0019749.5ELN, TGFB2
3extracellular matrix organizationGO:0301988.5ELN, LOXL1, TGFB2

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Open-Angle Glaucoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet