MCID: OPN001
MIFTS: 51

Open-Angle Glaucoma malady

Genetic diseases, Rare diseases, Eye diseases, Fetal diseases categories

Summaries for Open-Angle Glaucoma

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Disease Ontology:9 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

MalaCards based summary: Open-Angle Glaucoma, also known as wide-angle glaucoma nos, is related to ocular hypertension and primary angle-closure glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Estrogen metabolism and Degradation of the extracellular matrix. The drugs epinephrine hydrochloride and betaxolol and the compounds pyrene and 1-hydroxypyrene have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt
See all sources

Open-Angle Glaucoma, Aliases & Descriptions:

Name: Open-Angle Glaucoma 9
Wide-Angle Glaucoma Nos 9
Glaucoma, Open-Angle 60
Open Angle Glaucoma 9
 
Pigmentary Glaucoma 9
Glaucoma Open-Angle 43
Glaucoma Simplex 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:1067
MeSH33 D005902
NCIt38 C34641

Related Diseases for Open-Angle Glaucoma

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Diseases in the Open-Angle Glaucoma family:

Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1a, Primary Open Angle Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma, Primary Open Angle, Juvenile-Onset, 2 Glaucoma 1, Open Angle, 1o

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension32.4MYOC, OPTN
2primary angle-closure glaucoma32.0MYOC
3glaucoma 1a, primary open angle31.5MYOC, OPTN
4primary congenital glaucoma31.5CYP1B1
5blindness31.2MYOC, WDR36, OPTN
6exfoliation syndrome31.1ELN, LOXL1
7glaucoma 1, open angle, e30.3CYP1B1, OPTN, GSTM1, ELN, ASB10, MYOC
8retinitis11.0
9cataract10.8
10myopia10.8
11low tension glaucoma10.7
12endotheliitis10.6
13residual stage of open angle glaucoma10.6
14ocular hypotension10.6
15choroiditis10.5
16dementia10.5
17neuropathy10.5
18glaucoma, normal tension10.5
19pigment dispersion syndrome10.5
20retinal vein occlusion10.5
21senile cataract10.5
22nail-patella syndrome10.4
23glaucoma 1, open angle, p10.4
24pulmonary hypertension10.4
25central retinal vein occlusion10.4
26kearns-sayre syndrome10.4
27glaucomatocyclitic crisis10.4
28cerebritis10.4
29thyroiditis10.4
30nevus of ota10.4
31glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.3CYP1B1, MYOC
32vitreoretinopathy, neovascular inflammatory10.3TGFB2
33glaucoma 1, open angle, g10.2
34glaucoma 1, open angle, m10.2
35marfan syndrome10.2
36migraine10.2
37glaucoma 1, open angle, 1o10.2
38atherosclerosis10.2
39ischemic optic neuropathy10.2
40keratoconus10.2
41keratopathy10.2
42vascular dementia10.2
43neovascular glaucoma10.2
44juvenile glaucoma10.2
45waardenburg's syndrome10.2
46exophthalmos10.2
47degenerative myopia10.2
48conjunctivochalasis10.2
49neuroretinitis10.2
50cycloplegia10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Symptoms for Open-Angle Glaucoma

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Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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MalaCards organs/tissues related to Open-Angle Glaucoma:

31
Eye, Testes, Endothelial, Cortex, Brain, Retina, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Publications for Open-Angle Glaucoma

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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1079)
idTitleAuthorsYear
1
Correction: Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study. (25849906)
2015
2
Efficacy and safety of SNJ-1656 in primary open-angle glaucoma or ocular hypertension. (25783615)
2015
3
Risk factors for predicting visual field progression in Chinese patients with primary open-angle glaucoma: A retrospective study. (25819708)
2015
4
Genetic Association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the Endophenotypes of Primary Open Angle Glaucoma in Indian Population. (25798827)
2015
5
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
6
Open-angle glaucoma surgery: the current standing. (25295896)
2014
7
Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma. (25237590)
2014
8
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
9
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
10
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
11
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
12
Selective Laser Trabeculoplasty versus Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. (24367649)
2013
13
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
14
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
15
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
16
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
17
The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family. (23886590)
2013
18
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
19
Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. (23603758)
2013
20
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
21
Ocular rigidity, outflow facility, ocular pulse amplitude, and pulsatile ocular blood flow in open-angle glaucoma: a manometric study. (23761082)
2013
22
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension. (24180628)
2013
23
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
24
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
25
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
26
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
27
Primary open-angle glaucoma: everyone's business. (23520411)
2012
28
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
29
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
30
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
31
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
32
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
33
Five-year, multicenter safety study of fixed-combination latanoprost/timolol (Xalacom) for open-angle glaucoma and ocular hypertension. (20520568)
2011
34
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
35
Laser trabeculoplasty in the treatment of open-angle glaucoma. (21633246)
2011
36
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
37
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
38
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
39
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
40
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
41
Primary open-angle glaucoma. (19535810)
2009
42
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
43
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
44
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
45
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
46
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
47
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. (15216404)
2004
48
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
49
Molecular genetics of open-angle glaucoma, moving from gene localization to predictive testing. (10168351)
1997
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Pathways related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GSTM1, CYP1B1
2
Show member pathways
8.8ELN, LOXL1, TGFB2
3
Show member pathways
8.8ELN, LOXL1, TGFB2

Compounds for genes affiliated with Open-Angle Glaucoma

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Compounds related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1pyrene4310.1GSTM1, CYP1B1
21-hydroxypyrene4310.1GSTM1, CYP1B1
3phip4310.1CYP1B1, GSTM1
4cotinine43 2411.1CYP1B1, GSTM1
5aflatoxin b143 2411.1GSTM1, CYP1B1
6hydrocarbons4310.0GSTM1, CYP1B1
7benzene4310.0GSTM1, ELN
8deoxypyridinoline439.9ELN, TGFB2
9quinone43 2410.9CYP1B1, GSTM1
10tcdd439.9TGFB2, CYP1B1
11alginate439.9TGFB2, ELN
12epoxide439.8GSTM1, CYP1B1
13glycosaminoglycan439.8TGFB2, MYOC, ELN
14hyaluronic acid43 2410.8TGFB2, MYOC, ELN
15oxaliplatin43 49 1211.7GSTM1, CYP1B1
16valine439.7CYP1B1, ELN, GSTM1
17betacarotene439.7GSTM1, ELN
18benzo(a)pyrene439.7GSTM1, TGFB2, CYP1B1
19p003439.7GSTM1, TGFB2, CYP1B1
20ozone439.6GSTM1, ELN, TGFB2
21vitamin a43 24 1211.6GSTM1, ELN, TGFB2
225fluorouracil439.6CYP1B1, TGFB2, GSTM1
23n acetylcysteine439.6ELN, TGFB2, CYP1B1
24vitamin d439.5GSTM1, ELN, TGFB2
25doxycycline43 1210.5ELN, CYP1B1
26cycloheximide439.4ELN, MYOC, TGFB2, CYP1B1
27ascorbic acid43 2410.4TGFB2, MYOC, ELN, GSTM1
28testosterone43 59 24 1212.3GSTM1, ELN, TGFB2, CYP1B1
29genistein43 28 59 2 24 1214.2CYP1B1, TGFB2, ELN
30dexamethasone43 49 28 1212.1CYP1B1, TGFB2, MYOC, ELN, OPTN
31arginine439.1MYOC, ELN, NTF4, GSTM1
32estrogen439.1GSTM1, ELN, TGFB2, CYP1B1
33cysteine439.0TGFB2, MYOC, ELN, GSTM1
34glutamate438.9CYP1B1, TGFB2, ELN, NTF4
35retinoic acid43 249.8CYP1B1, TGFB2, ELN, NTF4

GO Terms for genes affiliated with Open-Angle Glaucoma

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Cellular components related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.9LOXL1, MYOC, TGFB2

Biological processes related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.8MYOC, TGFB2
2blood vessel remodelingGO:00019749.5ELN, TGFB2
3extracellular matrix organizationGO:00301988.5ELN, LOXL1, TGFB2

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
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Sources for Open-Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet