MCID: OPN001
MIFTS: 49

Open-Angle Glaucoma malady

Categories: Eye diseases, Genetic diseases, Rare diseases, Fetal diseases

Aliases & Classifications for Open-Angle Glaucoma

Aliases & Descriptions for Open-Angle Glaucoma:

Name: Open-Angle Glaucoma 12 14
Glaucoma, Open-Angle 42 69
Open Angle Glaucoma 12
Pigmentary Glaucoma 12
Wide-Angle Glaucoma 12
Glaucoma Open-Angle 52
Glaucoma Simplex 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1067
MeSH 42 D005902
NCIt 47 C34641
UMLS 69 C0017612

Summaries for Open-Angle Glaucoma

Disease Ontology : 12 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

MalaCards based summary : Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to residual stage of open angle glaucoma and glaucoma 1, open angle, e. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. The drugs Travoprost and Apraclonidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Related Diseases for Open-Angle Glaucoma

Diseases in the Open-Angle Glaucoma family:

Glaucoma 1a, Primary Open Angle Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma, Primary Open Angle, Juvenile-Onset, 2

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
id Related Disease Score Top Affiliating Genes
1 residual stage of open angle glaucoma 12.3
2 glaucoma 1, open angle, e 12.2
3 glaucoma 1a, primary open angle 12.0
4 glaucoma 1, open angle, p 11.9
5 glaucoma 1, open angle, f 11.9
6 glaucoma 1, open angle, g 11.8
7 glaucoma 1, open angle, 1o 11.8
8 exfoliation syndrome 11.5
9 ocular hypertension 10.9
10 retinitis 10.6
11 primary angle-closure glaucoma 10.5
12 cataract 10.4
13 myopia 10.3
14 baraitser-winter syndrome 10.3 CYP1B1 OPTN
15 pituitary hormone deficiency, combined, 4 10.3 CYP1B1 MYOC OPTN
16 chronic tympanitis 10.3 CYP1B1 MYOC OPTN
17 opisthorchiasis 10.3 CYP1B1 MYOC OPTN
18 endotheliitis 10.3
19 red-green color vision defects 10.3 CYP1B1 MYOC WDR36
20 mental retardation, autosomal dominant 33 10.3 ASB10 OPTN WDR36
21 peters anomaly 10.3 CYP1B1 MYOC OPTN
22 neuropathy 10.3
23 scapuloperoneal syndrome, myopathic type 10.2 ASB10 OPTN
24 hereditary xanthinuria 10.2 CYP1B1 MYOC
25 glaucoma, normal tension 10.2
26 acute poststreptococcal glomerulonephritis 10.2 CYP1B1 GSTM1 MYOC OPTN
27 idiopathic corneal edema 10.2 CYP1B1 MMP1 MYOC OPTN
28 choroiditis 10.2
29 primary congenital glaucoma 10.2
30 conjunctival folliculosis 10.2 CYP1B1 OPTN
31 schizencephaly 10.2 SIX1 SIX6
32 ocular hypotension 10.2
33 mechanical strabismus 10.1 LMX1B MYOC OPTN
34 mixed gonadal dysgenesis 10.1 OPTN TGFB2
35 nevoid hypermelanosis, linear and whorled 10.1 CYP1B1 MMP1 MYOC OPTN WDR36
36 muir-torre syndrome 10.1 CYP1B1 MYOC TGFB2
37 olecranon bursitis 10.1 ELN LOXL1 OPTN
38 allergic contact dermatitis of eyelid 10.1 ELN MYOC OPTN
39 ischemic optic neuropathy 10.1
40 dementia 10.1
41 glaucoma 1, open angle, n 10.1 ELN LOXL1 MMP1
42 retinal vein occlusion 10.0
43 senile cataract 10.0
44 morbid obesity and spermatogenic failure 10.0 CDKN2B-AS1 LOXL1 MYOC OPTN TBK1 WDR36
45 algoneurodystrophy 10.0 ELN MMP1 TGFB2
46 pulmonary hypertension 10.0
47 nevus of ota 10.0
48 central retinal vein occlusion 10.0
49 cerebritis 10.0
50 scotoma 10.0

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to Open-Angle Glaucoma

Symptoms & Phenotypes for Open-Angle Glaucoma

Drugs & Therapeutics for Open-Angle Glaucoma

Drugs for Open-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 205)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Travoprost Approved Phase 4,Phase 3,Phase 2,Phase 1 157283-68-6 5282226
2
Apraclonidine Approved Phase 4 66711-21-5 2216
3
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
4
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130209-82-4 5282380 5311221
5
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
6
Dorzolamide Approved Phase 4,Phase 2,Phase 3 120279-96-1 3154 5284549
7
Timolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 26839-75-8 33624 5478
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Brinzolamide Approved Phase 4,Phase 3,Phase 2 138890-62-7 68844
10
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155206-00-1 5311027
11
Sorbitol Approved Phase 4 50-70-4 5780
12
Pilocarpine Approved Phase 4 54-71-7, 92-13-7 5910
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
14
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
15
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
16
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
17
Bevacizumab Approved, Investigational Phase 4 216974-75-3
18
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
19
Maleic acid Experimental Phase 4,Phase 3,Phase 1,Phase 2 110-16-7 444266
20 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
22 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
23 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Phase 1 70359-46-5
24 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
29 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1
33 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Ketorolac Tromethamine Phase 4
37 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
38 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
39 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
42 Mitomycins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Alkylating Agents Phase 4,Phase 3,Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
45 Lubricant Eye Drops Phase 4,Phase 3,Phase 2
46 Cloprostenol Phase 4,Phase 3
47 Contraceptive Agents Phase 4,Phase 3
48 Luteolytic Agents Phase 4,Phase 3
49 Cathartics Phase 4
50 Gastrointestinal Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 650)
id Name Status NCT ID Phase
1 The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma Unknown status NCT02388360 Phase 4
2 Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty Unknown status NCT01444105 Phase 4
3 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
4 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
5 A Study of the Glaukos Trabecular Micro-bypass Stent in Open Angle Glaucoma Subjects 1 Stent Versus 2 Unknown status NCT00326079 Phase 4
6 Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost Unknown status NCT01443988 Phase 4
7 Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents Unknown status NCT01252888 Phase 4
8 Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost Unknown status NCT01444040 Phase 4
9 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4
10 Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents Unknown status NCT01252862 Phase 4
11 Purpose of This Study is to Evaluate the Safety and Efficacy of One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects Unknown status NCT01252849 Phase 4
12 Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma Unknown status NCT01580254 Phase 4
13 Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension Unknown status NCT02047630 Phase 4
14 PASCAL Trabeculoplasty Unknown status NCT00804323 Phase 4
15 Prospective, Randomized, Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG Unknown status NCT02231515 Phase 4
16 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4
17 The Laser in Pseudoexfoliation (LIP) Study Unknown status NCT01704989 Phase 4
18 Choroidal Thickness in Glaucoma Patients and Healthy Controls Unknown status NCT01293474 Phase 4
19 Reproducibility of RNFL Circle Scans With ART-Function of Heidelberg Spectralis SD-OCT Software Version 5.3 Unknown status NCT01299233 Phase 4
20 Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves Unknown status NCT01883856 Phase 4
21 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
22 Non Interventional Study With Primary Open Angle Glaucoma and/or Ocular Hypertension Patients Treated With Xalacom® After Failure of Previous Antiglaucoma Therapy. Completed NCT00801437 Phase 4
23 A Study of the Glaukos Trabecular Micro-Bypass Stent in Refractory Open Angle Glaucoma Subjects Completed NCT00326040 Phase 4
24 A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma Completed NCT00911924 Phase 4
25 Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) Completed NCT00913029 Phase 4
26 An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More Completed NCT01979913 Phase 4
27 24-hour Intraocular Pressure (IOP) Control With Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combination in Open-angle Glaucoma Completed NCT00397241 Phase 4
28 A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00326014 Phase 4
29 A Study to Assess the Efficacy of 3 Months of Latanoprost Treatment in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma Completed NCT00647101 Phase 4
30 Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®) Completed NCT01464424 Phase 4
31 Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED) Completed NCT00545064 Phase 4
32 Safety and Efficacy of Bimatoprost/Timolol Fixed Combination Versus Latanoprost in Patients With Open-Angle Glaucoma Who Have Never Been Treated Completed NCT01243567 Phase 4
33 Patient Satisfaction With Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00804648 Phase 4
34 Non Interventional Study in Patients With Open Angle Glaucoma and/or Ocular Hypertension Treated With XALATAN® Completed NCT00486252 Phase 4
35 Phase IV Randomised Double-masked Clinical Trial: Assessing Morning Versus Evening Dosing of a Fixed Dose Combination of Travoprost 0.004% / Timolol Maleate 0.5% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00759239 Phase 4
36 Efficacy And Safety Of Xalatan Compared To Usual Care In Patients With Open Angle Glaucoma Or Ocular Hypertension. Completed NCT00140062 Phase 4
37 A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Completed NCT00527592 Phase 4
38 A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma Completed NCT00887029 Phase 4
39 A Study of 0.03% Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension Completed NCT02020512 Phase 4
40 A Study of 0.15% Brimonidine Tartrate in Patients With Primary Open Angle Glaucoma and Ocular Hypertension Completed NCT02003534 Phase 4
41 A Study of Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension Completed NCT02061683 Phase 4
42 A Safety and Efficacy Study of Bimatoprost 0.01% in Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OH) Completed NCT01594970 Phase 4
43 Ocular Surface Tolerability Study of Prostaglandin Analogues in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed NCT01253902 Phase 4
44 Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma Completed NCT00444080 Phase 4
45 Efficacy and Safety of Travoprost 0.004% Versus Tafluprost 0.0015% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00966940 Phase 4
46 Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Completed NCT00698945 Phase 4
47 Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP) Completed NCT01162603 Phase 4
48 Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed NCT01978600 Phase 4
49 Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Completed NCT02325518 Phase 4
50 A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan® UD Monotherapy for Medical Reasons Completed NCT01853085 Phase 4

Search NIH Clinical Center for Open-Angle Glaucoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: glaucoma, open-angle

Genetic Tests for Open-Angle Glaucoma

Anatomical Context for Open-Angle Glaucoma

MalaCards organs/tissues related to Open-Angle Glaucoma:

39
Eye, Testes, Endothelial, Cortex, Brain, Retina, Thyroid

Publications for Open-Angle Glaucoma

Articles related to Open-Angle Glaucoma:

(show top 50) (show all 1247)
id Title Authors Year
1
Canaloplasty with Stegmann Canal Expander for primary open-angle glaucoma: two-year clinical results. ( 28083899 )
2017
2
Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue. ( 28053501 )
2017
3
The role of hypertension in retinal blood flow alterations in open-angle glaucoma patients. ( 28084046 )
2017
4
Open-Angle Glaucoma: Drug Development Pipeline during the Last 20 Years (1995-2015). ( 28076854 )
2017
5
The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma. ( 27941048 )
2017
6
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. ( 28073927 )
2017
7
Ocular characteristics associated with the location of focal lamina cribrosa defects in open-angle glaucoma patients. ( 27935604 )
2016
8
Patients with Primary Open-Angle Glaucoma May Develop Ischemic Heart Disease More Often than Those without Glaucoma: An 11-Year Population-Based Cohort Study. ( 27649414 )
2016
9
Determination of Serum Ceruloplasmin Concentration in Patients with Primary Open Angle Glaucoma with Cataract and Patients with Cataract Only: A Pilot Study. ( 27109647 )
2016
10
Stab Incision Glaucoma Surgery: A Modified Guarded Filtration Procedure for Primary Open Angle Glaucoma. ( 27144015 )
2016
11
Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans. ( 27217714 )
2016
12
Glaukos iStent injectAr Trabecular Micro-Bypass Implantation Associated with Cataract Surgery in Patients with Coexisting Cataract and Open-Angle Glaucoma or Ocular Hypertension: A Long-Term Study. ( 27882243 )
2016
13
Comparison of the Deep Optic Nerve Structures in Superior Segmental Optic Nerve Hypoplasia and Primary Open-Angle Glaucoma. ( 26950571 )
2016
14
ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment. ( 27133047 )
2016
15
Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population. ( 27260188 )
2016
16
Real-Time Ultrasound Elastographic Features of Primary Open Angle Glaucoma. ( 27599308 )
2016
17
Retinal and choroidal oxygen saturation of the optic nerve head in open-angle glaucoma subjects by multispectral imaging. ( 28033298 )
2016
18
The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. ( 27162226 )
2016
19
Retinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera. ( 27612016 )
2016
20
Impact of Socioeconomic Status on the Diagnosis of Primary Open-Angle Glaucoma and Primary Angle Closure Glaucoma: A Nationwide Population-Based Study in Taiwan. ( 26905307 )
2016
21
Trabeculectomy Versus Ex-Press Glaucoma Filtration Device in Silicomacrophagocytic Open Angle Glaucoma Secondary to Silicone Oil Emulsification. ( 27162449 )
2016
22
Sutureless Scleral Tunnel Trabeculectomy: Evaluation of Feasibility and Effectiveness versus Conventional Trabeculectomy for Management of Primary Open Angle Glaucoma. ( 27960578 )
2016
23
A Randomized Controlled Trial to Determine the Effect of Inhaled Corticosteroid on Intraocular Pressure in Open-Angle Glaucoma and Ocular Hypertension: The ICOUGH Study. ( 27096722 )
2016
24
SU-F-I-18: Altered Visual Cortex Responses by Wide-View FMRI in Primary Open Angle Glaucoma Patients. ( 28048887 )
2016
25
Long-term Safety and Efficacy of Latanoprostene Bunod 0.024% in Japanese Subjects with Open-Angle Glaucoma or Ocular Hypertension: The JUPITER Study. ( 27457469 )
2016
26
Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma. ( 27435453 )
2016
27
Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma. ( 27341769 )
2016
28
Vessel Caliber in Normal Tension and Primary Open Angle Glaucoma Eyes With Hemifield Damage. ( 27636594 )
2016
29
Macular Pigment Optical Density in Chinese Primary Open Angle Glaucoma Using the One-Wavelength Reflectometry Method. ( 27144013 )
2016
30
Preservative-free tafluprost in the treatment of open-angle glaucoma or ocular hypertension in India: a phase III clinical trial. ( 27292765 )
2016
31
Myocilin Predictive Genetic Testing for Primary Open-Angle Glaucoma Leads to Early Identification of At-Risk Individuals. ( 27993484 )
2016
32
Patient-Reported Vision-Related Quality-of-Life Differences between Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma. ( 27690232 )
2016
33
Estimated Cerebrospina Fluid Pressure and the 5-Year Incidence of Primary Open-Angle Glaucoma in a Chinese Population. ( 27611879 )
2016
34
Association of Myopic Optic Disc Deformation with Visual Field Defects in Paired Eyes with Open-Angle Glaucoma: A Cross-Sectional Study. ( 27571303 )
2016
35
Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma. ( 27001270 )
2016
36
Association between systemic oxidative stress and visual field damage in open-angle glaucoma. ( 27165400 )
2016
37
MRI Study of the Posterior Visual Pathways in Primary Open Angle Glaucoma. ( 27661989 )
2016
38
Toward Novel Diagnostics for Primary Open-Angle Glaucoma? An Association Study of Polymorphic Variation in Ras Homolog Family Member (A, B, C, D) Genes RHOA, RHOB, RHOC, and RHOD. ( 27195967 )
2016
39
Comparison of canaloplasty and trabeculectomy for open angle glaucoma: a Meta-analysis. ( 28003985 )
2016
40
Management of patients with chronic open angle glaucoma. ( 27206206 )
2016
41
Lack of Association Between Polymorphism rs4986791 in TLR4 and Primary Open-Angle Glaucoma in a Saudi Cohort. ( 27526043 )
2016
42
Comparison of Latanoprostene Bunod 0.024% and Timolol Maleate 0.5% in Open-Angle Glaucoma or Ocular Hypertension: the LUNAR Study. ( 27210275 )
2016
43
Elevated Plasma Endothelin-1 Levels in Normal Tension Glaucoma and Primary Open-Angle Glaucoma: A Meta-Analysis. ( 27965889 )
2016
44
Analysis of Toll-Like Receptor 2 Polymorphism (rs5743704) in Saudi Patients with Primary Open-Angle Glaucoma. ( 26866668 )
2016
45
The Effects of Nocturnal Dip and Blood Pressure Variability on Paracentral Scotoma in Early Open-Angle Glaucoma. ( 27128963 )
2016
46
The association between cigarette smoking and primary open-angle glaucoma: a systematic review. ( 27138591 )
2016
47
Tolerability and efficacy of bimatoprost 0.01A % in patients with open-angle glaucoma or ocular hypertension evaluated in the Taiwanese clinical setting: the Asia Pacific Patterns from Early Access of Lumigan 0.01A % (APPEAL Taiwan) study. ( 27633513 )
2016
48
Longitudinal Analysis of Serum Autoantibody-Reactivities in Patients with Primary Open Angle Glaucoma and Optic Disc Hemorrhage. ( 28030545 )
2016
49
Primary open-angle glaucoma. ( 27654752 )
2016
50
Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up. ( 27174381 )
2016

Variations for Open-Angle Glaucoma

Expression for Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for Open-Angle Glaucoma

Pathways related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ELN LOXL1 MMP1 OPTC TGFB2
2
Show member pathways
11.2 ELN LOXL1 TGFB2
3 11.07 CAV1 CAV2 GSTM1 GSTT1

GO Terms for Open-Angle Glaucoma

Cellular components related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 LOXL1 MMP1 MYOC TGFB2
2 acrosomal membrane GO:0002080 9.16 CAV1 CAV2
3 proteinaceous extracellular matrix GO:0005578 9.02 ELN LOXL1 MMP1 MYOC OPTC

Biological processes related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.5 ELN MMP1 OPTC
2 vesicle organization GO:0016050 9.43 CAV1 CAV2
3 glutathione derivative biosynthetic process GO:1901687 9.4 GSTM1 GSTT1
4 generation of neurons GO:0048699 9.37 SIX1 TGFB2
5 skeletal muscle tissue development GO:0007519 9.33 CAV1 ELN SIX1
6 positive regulation of xenophagy GO:1904417 9.26 OPTN TBK1
7 caveola assembly GO:0070836 8.96 CAV1 CAV2
8 receptor-mediated endocytosis of virus by host cell GO:0019065 8.62 CAV1 CAV2

Molecular functions related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 8.8 CAV1 CAV2 OPTN

Sources for Open-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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