MCID: OPN001
MIFTS: 56

Open-Angle Glaucoma malady

Eye diseases category

Summaries for Open-Angle Glaucoma

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46OMIM, 32MalaCards
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MalaCards: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to glaucoma and primary open angle glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Naphthalene metabolism and Estrogen metabolism. The drugs epinephrine hydrochloride and epinephrine and the compounds vitamin a and cysteine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 613100,609887,137750

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 46OMIM, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

open-angle glaucoma 8
open-angle glaucoma, unspecified 8
unspecified open-angle glaucoma 8
wide-angle glaucoma nos 8
open-angle glaucoma nos 8
glaucoma, open-angle 60
open angle glaucoma 8
pigmentary glaucoma 8
glaucoma open-angle 44
glaucoma simplex 8


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Disease Ontology8 DOID:1067
NCIt39 C34641
MeSH34 D005902
ICD1025 H40.1

Related Diseases for Open-Angle Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

Primary Open Angle Glaucoma open-angle glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.5TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
2primary open angle glaucoma32.4MYOC, RHO, OPTN, COCH, CYP1B1, ABCA4
3ocular hypertension31.9OPTN, MYOC
4retinitis31.3RHO
5primary angle-closure glaucoma31.3MYOC
6cataract31.1TGFB2, MYOC, RHO
7primary open angle glaucoma juvenile onset 130.9MYOC, CYP1B1
8primary congenital glaucoma30.7CYP1B1
9diabetic retinopathy30.5TGFB2, RHO
10eye disease30.2OPTN, RHO, MYOC, ABCA4, TGFB2
11age related macular degeneration30.2RHO
12hypertension11.3
13juvenile glaucoma11.0
14myopia10.7
15low tension glaucoma10.7
16exfoliation syndrome10.7
17residual stage of open angle glaucoma10.5
18neuropathy10.5
19ocular hypotension10.5
20glaucoma 1, open angle, e10.5
21choroiditis10.4
22retinal vein occlusion10.4
23senile cataract10.4
24primary pulmonary hypertension10.3
25nail-patella syndrome10.3
26glaucomatocyclitic crisis10.3
27kearns-sayre syndrome10.3
28central retinal vein occlusion10.3
29alzheimer's disease10.3
30dementia10.3
31thyroiditis10.3
32pigment-dispersion syndrome10.2
33ischemic retinopathy10.2
34marfan syndrome10.2
35steroid-induced glaucoma - borderline10.2
36neovascular glaucoma10.2
37neuroretinitis10.2
38cycloplegia10.2
39lens subluxation10.2
40anisometropia10.2
41cerebritis10.2
42retinal lattice degeneration10.2
43bullous keratopathy10.2
44exudative vitreoretinopathy10.2
45ischemic neuropathy10.2
46exophthalmos10.2
47waardenburg's syndrome10.2
48degenerative myopia10.2
49diabetic cataract10.2
50ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Clinical Features for Open-Angle Glaucoma

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Sources:
46OMIM
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Clinical features from OMIM:

613100,609887,137750

Drugs & Therapeutics for Open-Angle Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Open-Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Retina, Cortex, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Open-Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.7TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Open-Angle Glaucoma

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Sources:
50PubMed
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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1043)
idTitleAuthorsYear
1
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
2
Chromosome 9p21 primary open-angle glaucoma susceptibility locus: a review. (24112133)
2014
3
Optical coherence tomography of the suprachoroid after CyPass Micro-Stent implantation for the treatment of open-angle glaucoma. (23743436)
2014
4
Correction: Status of Systemic Oxidative Stresses in Patients with Primary Open-Angle Glaucoma and Pseudoexfoliation Syndrome. (24392039)
2014
5
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
6
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
7
Direct cost and predictive factors for treatment in patients with ocular hypertension or early, moderate and advanced primary open-angle glaucoma: the CoGIS study in Germany. (23624617)
2013
8
Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage. (23223846)
2013
9
Clinical correlates to the goniodysgensis among juvenile-onset primary open-angle glaucoma patients. (23358655)
2013
10
Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. (22605928)
2012
11
Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma. (21960068)
2012
12
Status of systemic oxidative stresses in patients with primary open-angle glaucoma and pseudoexfoliation syndrome. (23189153)
2012
13
Open-angle glaucoma and the risk of erectile dysfunction: a population-based case-control study. (22036631)
2012
14
Selective laser trabeculoplasty in Egyptian patients with primary open-angle glaucoma. (22837623)
2012
15
Reduction of intraocular pressure using a modified 360-degree suture trabeculotomy technique in primary and secondary open-angle glaucoma: a pilot study. (21543994)
2012
16
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. (22661486)
2012
17
Biomarkers in primary open angle glaucoma. (22745021)
2012
18
Absence of altered expression of optineurin in primary open angle glaucoma patients. (22690120)
2012
19
Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. (22831837)
2012
20
Incidence of, risk factors for, and combined mechanism of late-onset open-angle glaucoma after vitrectomy. (21765372)
2012
21
Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility. (21709622)
2011
22
Short-term effects of acupuncture on open-angle glaucoma in retrobulbar circulation: additional therapy to standard medication. (21437193)
2011
23
Head trauma can cause transient elevation of intraocular pressure in patients with open angle glaucoma. (22553666)
2011
24
Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma. (22553514)
2010
25
Heterozygous loss-of-function variants in CYP1B1 predispose to primary open-angle glaucoma. (19643970)
2010
26
Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma. (19549102)
2010
27
Effect of dorzolamide and timolol on ocular pressure: blood flow relationship in patients with primary open-angle glaucoma and ocular hypertension. (19850848)
2010
28
Prevalence of and risk factors for primary open-angle glaucoma in central Sri Lanka: the Kandy eye study. (20642343)
2010
29
Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. (19145250)
2009
30
Primary open angle glaucoma and intraocular pressure in patients with systemic hypertension. (19894471)
2009
31
Ocular hypotensive efficacy and safety of travoprost 0.004% in inadequately controlled primary open-angle glaucoma or ocular hypertension: short-term, multicenter, prospective study. (19210139)
2009
32
Current concepts in the diagnosis of primary open angle glaucoma. (20306727)
2009
33
Secondary open-angle glaucoma and central retinal vein occlusion in a patient with primary pulmonary hypertension. (19205497)
2009
34
The accuracy and clinical application of predictive models for primary open-angle glaucoma in ocular hypertensive individuals. (18801578)
2008
35
A 5-year, randomized, open-label safety study of latanoprost and usual care in patients with open-angle glaucoma or ocular hypertension. (18465724)
2008
36
Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. (19096531)
2008
37
Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma]. (17605937)
2007
38
A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q. (16518310)
2006
39
A three-month, multicenter, double-masked study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to travoprost 0.004% ophthalmic solution and timolol 0.5% dosed concomitantly in subjects with open angle glaucoma or ocular hypertension. (16148589)
2005
40
Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (15677485)
2005
41
Genetics and bioinformatics of primary open angle glaucoma: an Indian perspective. (15871358)
2004
42
Mutations in MYOC gene of Indian primary open angle glaucoma patients. (12447164)
2002
43
Genetic screening in a large family with juvenile onset primary open angle glaucoma. (10873982)
2000
44
A GLC1A gene Gln368Stop mutation in a patient with normal-tension open-angle glaucoma. (10209734)
1999
45
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
46
Founder effect in GLC1A-linked familial open-angle glaucoma in Northern France. (9556305)
1998
47
Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma. (9328473)
1997
48
Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. (19920577)
1994
49
Prevalence of senile cataract, diabetic retinopathy, senile macular degeneration, and open-angle glaucoma in the Framingham eye study. (619683)
1978
50
Nevus of Ota. Report of two cases, one with open-angle glaucoma. (13893298)
1962

Genetic Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN
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Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Naphthalene metabolism
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10.6GSTM1, CYP1B1
2
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10.6GSTM1, CYP1B1
3
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10.6TGFB2, ELN
4
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10.6TGFB2, ELN

Compounds for genes affiliated with Open-Angle Glaucoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2413.0TGFB2, ELN, GSTM1, ABCA4, RHO
2cysteine4410.9COCH, RHO, MYOC, GSTM1, ELN, TGFB2
3valine4410.9ELN, GSTM1, CYP1B1, RHO
4ozone4410.9GSTM1, ELN, TGFB2
5benzo(a)pyrene4410.9CYP1B1, GSTM1, TGFB2
6ascorbic acid44 2411.9MYOC, GSTM1, ELN, TGFB2
7betacarotene4410.9ELN, GSTM1, RHO
8pyrene4410.8GSTM1, CYP1B1
91-hydroxypyrene4410.7GSTM1, CYP1B1
10glycosaminoglycan4410.7MYOC, ELN, TGFB2
1111-cis-retinol44 2411.7ABCA4, RHO
12dexamethasone44 49 28 1113.7OPTN, MYOC, CYP1B1, ELN, TGFB2
13p0034410.7TGFB2, GSTM1, CYP1B1
14arginine4410.6RHO, NTF4, MYOC, GSTM1, ELN
15cotinine44 2411.6GSTM1, CYP1B1
16phip4410.3GSTM1, CYP1B1

GO Terms for genes affiliated with Open-Angle Glaucoma

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Sources:
16Gene Ontology
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Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.6ABCA4, RHO

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Open-Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet