MCID: OPN001
MIFTS: 51

Open-Angle Glaucoma

Categories: Eye diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Open-Angle Glaucoma

MalaCards integrated aliases for Open-Angle Glaucoma:

Name: Open-Angle Glaucoma 12 14
Glaucoma, Open-Angle 41 69
Open Angle Glaucoma 12
Pigmentary Glaucoma 12
Wide-Angle Glaucoma 12
Glaucoma Open-Angle 51
Glaucoma Simplex 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1067
MeSH 41 D005902
NCIt 46 C34641
UMLS 69 C0017612

Summaries for Open-Angle Glaucoma

Disease Ontology : 12 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

MalaCards based summary : Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to glaucoma 1, open angle, a and exfoliation syndrome. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. The drugs Apraclonidine and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Related Diseases for Open-Angle Glaucoma

Diseases in the Open-Angle Glaucoma family:

Glaucoma 1, Open Angle, a Glaucoma, Primary Open Angle
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 glaucoma 1, open angle, a 34.3 CYP1B1 MYOC OPTN
2 exfoliation syndrome 32.2 ELN GSTT1 LOXL1 MMP1
3 ocular hypertension 32.2 MYOC OPTN TMCO1
4 intraocular pressure quantitative trait locus 31.9 CYP1B1 LMX1B LOXL1 MYOC OPTN WDR36
5 primary angle-closure glaucoma 31.6 CYP1B1 MYOC OPTN
6 glaucoma, normal tension 31.2 LOXL1 OPTN
7 glaucoma, primary open angle 31.2 ASB10 CAV2 CDKN2B-AS1 CYP1B1 ELN GSTM1
8 glaucoma 3, primary congenital, a 31.1 CYP1B1 MYOC OPTN
9 primary congenital glaucoma 31.0 CYP1B1 MYOC OPTN WDR36
10 low tension glaucoma 30.9 CDKN2B-AS1 MYOC OPTN TBK1 WDR36
11 chronic closed-angle glaucoma 30.6 OPTN TGFB2
12 neovascular glaucoma 29.8 OPTN TGFB2
13 juvenile glaucoma 29.2 CYP1B1 ELN MYOC NTF4 OPTN TGFB2
14 residual stage of open angle glaucoma 12.4
15 glaucoma 1, open angle, f 12.2
16 glaucoma 1, open angle, p 12.0
17 glaucoma 1, open angle, g 11.9
18 glaucoma 1, open angle, o 11.9
19 glaucoma 1, open angle, d 11.5
20 glaucoma 1, primary open angle, c 11.3
21 retinitis 10.7
22 acrofrontofacionasal dysostosis 10.6 CYP1B1 OPTN
23 hydrophthalmos 10.5 CYP1B1 OPTN
24 excessive tearing 10.5 CYP1B1 MYOC OPTN
25 cataract 10.5
26 hearing loss, noise-induced 10.5 GSTM1 GSTT1
27 early-onset glaucoma 10.5 CYP1B1 MYOC
28 myopia 10.4
29 axenfeld-rieger syndrome, type 2 10.4 ASB10 OPTN
30 sister chromatid exchange, frequency of 10.4 GSTM1 GSTT1
31 neuropathy 10.4
32 endotheliitis 10.4
33 aging 10.3
34 choroiditis 10.3
35 isolated cleft lip 10.3 GSTM1 GSTT1
36 corneal edema 10.3 CYP1B1 MMP1 MYOC OPTN
37 helicobacter pylori infection 10.3
38 glaucoma 3, primary infantile, b 10.3
39 ischemic optic neuropathy 10.3
40 holoprosencephaly 2 10.2 SIX1 SIX6
41 retinal vein occlusion 10.2
42 ocular hypotension 10.2
43 optic nerve disease 10.2 ELN MYOC OPTN
44 dementia 10.2
45 phacogenic glaucoma 10.2 ELN LOXL1 OPTN
46 oral leukoplakia 10.2 GSTM1 GSTT1
47 alzheimer disease 10.1
48 nonarteritic anterior ischemic optic neuropathy 10.1
49 macular degeneration, age-related, 1 10.1
50 senile cataract 10.1

Comorbidity relations with Open-Angle Glaucoma via Phenotypic Disease Network (PDN):


Anatomical Narrow Angle Borderline Glaucoma Glaucoma, Primary Open Angle
Hypertension, Essential Ocular Hypotension

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to Open-Angle Glaucoma

Symptoms & Phenotypes for Open-Angle Glaucoma

Drugs & Therapeutics for Open-Angle Glaucoma

Drugs for Open-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 206)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apraclonidine Approved Phase 4 66711-21-5 2216
2
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 299-42-3 9294
3
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130209-82-4 5311221 5282380
4
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 90-82-4 7028
5
Travoprost Approved Phase 4,Phase 3,Phase 2,Phase 1 157283-68-6 5282226
6
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 155206-00-1 5311027
7
Dorzolamide Approved Phase 4,Phase 3,Phase 2 120279-96-1 5284549 3154
8
Timolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 26839-75-8 5478 33624
9
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
10
Brinzolamide Approved Phase 4,Phase 3,Phase 2 138890-62-7 68844
11
Sorbitol Approved Phase 4 50-70-4 5780
12
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
13
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
14
Bevacizumab Approved, Investigational Phase 4 216974-75-3
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
16
Loteprednol Approved Phase 4 129260-79-3, 82034-46-6 9865442 444025
17
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
18
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
19
Maleic acid Experimental Phase 4,Phase 3,Phase 1,Phase 2 110-16-7 444266
20 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Phase 1 70359-46-5
22 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
28 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1
33 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Carbonic Anhydrase Inhibitors Phase 4,Phase 3,Phase 2
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Ketorolac Tromethamine Phase 4
37 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
38 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
39 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
42 Mitomycins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Alkylating Agents Phase 4,Phase 3,Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
45 Lubricant Eye Drops Phase 4,Phase 3,Phase 2
46 Anti-Infective Agents Phase 4,Phase 2
47 Anti-Infective Agents, Local Phase 4,Phase 2
48 Benzalkonium Compounds Phase 4,Phase 2
49 Cloprostenol Phase 4,Phase 3
50 Contraceptive Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 691)

# Name Status NCT ID Phase Drugs
1 Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty Unknown status NCT01444105 Phase 4
2 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
3 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
4 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4
5 A Study of the Glaukos Trabecular Micro-bypass Stent in Open Angle Glaucoma Subjects 1 Stent Versus 2 Unknown status NCT00326079 Phase 4
6 One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects Unknown status NCT01517477 Phase 4
7 Purpose of This Study is to Evaluate the Safety and Efficacy of One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects Unknown status NCT01252849 Phase 4
8 The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma Unknown status NCT02388360 Phase 4 topical prostaglandin analogs
9 Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma Unknown status NCT01580254 Phase 4 IOPIZE© Latanoprost eyedrops;GALAXIA© Latanoprost eyedrops;Latanoprost RATIOPHARM© latanoprost eyedrops
10 PASCAL Trabeculoplasty Unknown status NCT00804323 Phase 4
11 Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension Unknown status NCT02796560 Phase 4 Brand name travoprost;Generic travoprost
12 Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose Unknown status NCT02017327 Phase 4 Monoprost;Lumigan 0.01%;Lumigan 0.03% Unit Dose
13 Prospective, Randomized, Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG Unknown status NCT02231515 Phase 4
14 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
15 The Laser in Pseudoexfoliation (LIP) Study Unknown status NCT01704989 Phase 4 Prostagladin
16 Choroidal Thickness in Glaucoma Patients and Healthy Controls Unknown status NCT01293474 Phase 4
17 Reproducibility of RNFL Circle Scans With ART-Function of Heidelberg Spectralis SD-OCT Software Version 5.3 Unknown status NCT01299233 Phase 4
18 Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves Unknown status NCT01883856 Phase 4
19 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
20 An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More Completed NCT01979913 Phase 4 Saflutan® 15 microgram/ml Augentropfen im Einzeldosisbehältnis
21 Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost Completed NCT01443988 Phase 4 Travoprost
22 Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents Completed NCT01252888 Phase 4
23 A Study of the Glaukos Trabecular Micro-Bypass Stent in Refractory Open Angle Glaucoma Subjects Completed NCT00326040 Phase 4
24 A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00326014 Phase 4
25 Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents Completed NCT01252862 Phase 4
26 24-hour Intraocular Pressure (IOP) Control With Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combination in Open-angle Glaucoma Completed NCT00397241 Phase 4 Drug: dorzolamide/timolol;Drug: latanoprost/timolol;dorzolamide/timolol and latanoprost;placebo (artificial tears)
27 Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®) Completed NCT01464424 Phase 4 Travoprost 0.004% ophthalmic solution;Bimatoprost 0.01% ophthalmic solution
28 Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED) Completed NCT00545064 Phase 4 dorzolamide hydrochloride (+) timolol maleate
29 Efficacy and Tolerability of an Innovative Formulation of BAK-free Latanoprost Completed NCT03331770 Phase 4 Latanoprost Ophthalmic Product
30 Phase IV Randomised Double-masked Clinical Trial: Assessing Morning Versus Evening Dosing of a Fixed Dose Combination of Travoprost 0.004% / Timolol Maleate 0.5% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00759239 Phase 4 Travoprost 0.004% / Timolol maleate 0.5%;Travoprost 0.004% / Timolol maleate 0.5%
31 A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma Completed NCT00911924 Phase 4
32 Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) Completed NCT00913029 Phase 4 latanoprost/timolol
33 A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Completed NCT00527592 Phase 4 Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®);Latanoprost ophthalmic solution 0.005% (XALATAN®)
34 A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma Completed NCT00887029 Phase 4 DuoTrav (travoprost-timolol ophthalmic drops);Xalacom (latanoprost-timolol ophthalmic drops)
35 Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Completed NCT02325518 Phase 4 Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension;Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution;Subject's habitual PGA monotherapy
36 Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed NCT01978600 Phase 4 Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension;Timolol Maleate 0.5%
37 Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Completed NCT00698945 Phase 4 Istalol and Optive;Alphagan
38 Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP) Completed NCT01162603 Phase 4 TAFLUPROST 0.0015% EYEDROPS;LATANOPROST 0.005% EYEDROPS
39 A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan® UD Monotherapy for Medical Reasons Completed NCT01853085 Phase 4 Bimatoprost Ophthalmic Solution
40 Efficacy and Safety of Travoprost 0.004% Versus Tafluprost 0.0015% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00966940 Phase 4 Travoprost 0.004% ophthalmic solution (TRAVATAN);Tafluprost 0.0015% ophthalmic solution
41 Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma Completed NCT00444080 Phase 4
42 Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN Completed NCT00798759 Phase 4 Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®);Latanoprost ophthalmic solution 0.005% (XALATAN®)
43 Travatan Versus Timoptic in Treating Open-angle Glaucoma or Ocular Hypertension Completed NCT00763061 Phase 4 Travoprost 0.004% Ophthalmic Solution (Travatan);Timolol 0.5% Ophthalmic Solution (Timoptic)
44 Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT00372827 Phase 4 Brinzolamide 1% added to Travoprost 0.004%
45 A Study to Assess the Efficacy of 3 Months of Latanoprost Treatment in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma Completed NCT00647101 Phase 4 Latanoprost
46 Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00822081 Phase 4 brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination;dorzolamide hcl 2%/ timolol maleate 0.5% fixed combination;brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy.;dorzolamide hcl 2%/timolol maleate 0.5% fixed combinatin as adjunctive to current prostaglandin therapy.
47 Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed NCT00822055 Phase 4 brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination;dorzolamide hcl 2%/timolol maleate 0.5% fixed combination;brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy;dorzolamide hcl 2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy
48 Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study Completed NCT00698438 Phase 4
49 Efficacy And Safety of Pneumatic Trabeculoplasty Completed NCT01540331 Phase 4
50 Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension Completed NCT03395535 Phase 4 Primary Medical Treatment Pathway

Search NIH Clinical Center for Open-Angle Glaucoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: glaucoma, open-angle

Genetic Tests for Open-Angle Glaucoma

Anatomical Context for Open-Angle Glaucoma

MalaCards organs/tissues related to Open-Angle Glaucoma:

38
Eye, Testes, Endothelial, Brain, Cortex, Bone, Retina

Publications for Open-Angle Glaucoma

Articles related to Open-Angle Glaucoma:

(show top 50) (show all 1320)
# Title Authors Year
1
Latanoprostene Bunod 0.024% in Subjects With Open-angle Glaucoma or Ocular Hypertension: Pooled Phase 3 Study Findings. ( 29194198 )
2018
2
Selective laser trabeculoplasty for primary open-angle glaucoma patients younger than 40 years. ( 29426447 )
2018
3
Case of Ab Interno Trabeculectomy in Juvenile Open-angle Glaucoma with 5-year Follow-up. ( 29426460 )
2018
4
Identification and genotype phenotype correlation of novel mutations in SIX6 gene in primary open angle glaucoma. ( 29405792 )
2018
5
Application of Bayes' to the prediction of referral decisions made by specialist optometrists in relation to chronic open angle glaucoma. ( 29422665 )
2018
6
The Efficacy of Transcorneal Electrical Stimulation for the Treatment of Primary Open-angle Glaucoma: A Pilot Study. ( 29415904 )
2018
7
Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma. ( 29320503 )
2018
8
Correction to: The Effect of Posture on Intraocular Pressure and Systemic Hemodynamic Parameters in Treated and Untreated Patients with Primary Open-Angle Glaucoma, by Katsanos, A., Dastiridou, A.I., Quaranta, L., Rulli, E., Riva, I., Dimasi, V., Tsironi, E.E., and Weinreb, R.N. J Ocul Pharmacol Ther 2017;33(8):598-603. DOI: 10.1089/jop.2017.0030. ( 29393727 )
2018
9
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. ( 29452408 )
2018
10
Risk of obstructive sleep apnea in open-angle glaucoma versus controls using the STOP-Bang questionnaire. ( 29426446 )
2018
11
Incidence of retinal vein occlusion in open-angle glaucoma: a nationwide, population-based study using the Korean Health Insurance Review and Assessment Database. ( 29360215 )
2018
12
Long-term titrated IOP control with one, two, or three trabecular micro-bypass stents in open-angle glaucoma subjects on topical hypotensive medication: 42-month outcomes. ( 29440867 )
2018
13
Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma. ( 29433851 )
2018
14
Factors associated with developing a fear of falling in subjects with primary open-angle glaucoma. ( 29433472 )
2018
15
Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma. ( 29401312 )
2018
16
Are we ready for genetic testing for primary open-angle glaucoma? ( 29379103 )
2018
17
The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma. ( 29384425 )
2018
18
The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma. ( 29417213 )
2018
19
Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. ( 29392307 )
2018
20
Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients. ( 29447914 )
2018
21
Differentiating Occult Branch Retinal Artery Occlusion from Primary Open-angle Glaucoma. ( 29370018 )
2018
22
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. ( 29449654 )
2018
23
Visual Disability among Juvenile Open Angle Glaucoma Patients. ( 29394204 )
2018
24
Long-term efficacy and safety of ExPress implantation for treatment of open angle glaucoma. ( 28944196 )
2017
25
Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue. ( 28053501 )
2017
26
Efficacy and safety of different regimens for primary open-angle glaucoma or ocular hypertension: a systematic review and network meta-analysis. ( 29144028 )
2017
27
Oxidative DNA damage and reduced expression of DNA repair genes: Role in primary open angle glaucoma (POAG). ( 28129013 )
2017
28
Association of intraocular pressure related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma. ( 28858414 )
2017
29
Assessment of peripapillary choroidal thickness in primary open-angle glaucoma patients with choroidal vascular prominence. ( 28929241 )
2017
30
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
31
Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis. ( 28845303 )
2017
32
Open-Angle Glaucoma: Drug Development Pipeline during the Last 20 Years (1995-2015). ( 28076854 )
2017
33
Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma. ( 28944195 )
2017
34
Erratum: Predictors of Intraocular Pressure After Phacoemulsification in Primary Open-Angle Glaucoma Eyes with Wide Versus Narrower Angles (An American Ophthalmological Society Thesis). ( 29412193 )
2017
35
Analysis of toll-like receptor rs4986790 polymorphism in Saudi patients with primary open angle glaucoma. ( 27064537 )
2017
36
Comparison of self-measured diurnal intraocular pressure profiles using rebound tonometry between primary angle closure glaucoma and primary open angle glaucoma patients. ( 28333942 )
2017
37
Selective Laser Trabeculoplasty vs. Fixed Combinations with Timolol in Practice: A Replacement Study in Primary Open Angle Glaucoma. ( 28845323 )
2017
38
Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway. ( 28952395 )
2017
39
Genetic Variant Near PLXDC2 Influences the Risk of Primary Open-angle Glaucoma by Increasing Intraocular Pressure in the Japanese Population. ( 28930887 )
2017
40
Success rates of 2-site phacoemulsification combined with fornix-based trabeculectomy using mitomycin C for primary angle-closure glaucoma and primary open-angle glaucoma in an Asian population. ( 28188405 )
2017
41
Change in Visual Field Progression Following Treatment Escalation in Primary Open-angle Glaucoma. ( 28834827 )
2017
42
Health care claims for primary open-angle glaucoma and retinal vein occlusion from an 11-year nationwide dataset. ( 28808282 )
2017
43
Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma. ( 28399536 )
2017
44
Preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% in patients with open-angle glaucoma and ocular hypertension: results of an open-label observational study. ( 28652689 )
2017
45
The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma. ( 27941048 )
2017
46
Diurnal macular choroidal area fluctuation in normal and primary open angle glaucoma groups. ( 28861348 )
2017
47
Contribution of Mutations in Known Mendelian Glaucoma Genes to Advanced Early-Onset Primary Open-Angle Glaucoma. ( 28282485 )
2017
48
Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis. ( 29179746 )
2017
49
Canaloplasty with Stegmann Canal Expander for primary open-angle glaucoma: two-year clinical results. ( 28083899 )
2017
50
Minimally-invasive glaucoma surgeries (MIGS) for open angle glaucoma: A systematic review and meta-analysis. ( 28850575 )
2017

Variations for Open-Angle Glaucoma

Expression for Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for Open-Angle Glaucoma

Pathways related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.68 ELN LOXL1 MMP1 OPTC TGFB2
2
Show member pathways
11 ELN LOXL1 TGFB2

GO Terms for Open-Angle Glaucoma

Cellular components related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.35 ELN LOXL1 MMP1 MYOC TGFB2
2 proteinaceous extracellular matrix GO:0005578 9.02 ELN LOXL1 MMP1 MYOC OPTC

Biological processes related to Open-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione derivative biosynthetic process GO:1901687 9.26 GSTM1 GSTT1
2 generation of neurons GO:0048699 9.16 SIX1 TGFB2
3 extracellular matrix disassembly GO:0022617 9.13 ELN MMP1 OPTC
4 positive regulation of xenophagy GO:1904417 8.62 OPTN TBK1

Sources for Open-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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