MCID: OPN001
MIFTS: 60

Open-Angle Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories
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Summaries for Open-Angle Glaucoma

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MalaCards based summary: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to ocular hypertension and primary angle-closure glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Estrogen metabolism and Degradation of the extracellular matrix. The drugs epinephrine hydrochloride and betaxolol and the compounds pyrene and 1-hydroxypyrene have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Descriptions from OMIM:46 137750,613100,609887

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 46OMIM, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
See all sources

Open-Angle Glaucoma, Aliases & Descriptions:

Name: Open-Angle Glaucoma 8
Open-Angle Glaucoma, Unspecified 8 62
Unspecified Open-Angle Glaucoma 8
Wide-Angle Glaucoma Nos 8
Open-Angle Glaucoma Nos 8
 
Glaucoma, Open-Angle 62
Pigmentary Glaucoma 8
Open Angle Glaucoma 8
Glaucoma Open-Angle 44
Glaucoma Simplex 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:1067
MeSH34 D005902
NCIt39 C34641
ICD1025 H40.1

Related Diseases for Open-Angle Glaucoma

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Diseases in the Glaucoma 1a, Primary Open Angle family:

Primary Open Angle Glaucoma open-angle glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension32.4MYOC, OPTN
2primary angle-closure glaucoma32.0MYOC
3primary open angle glaucoma31.6CYP1B1, OPTN, GSTM1, ELN, ASB10, MYOC
4primary open angle glaucoma juvenile onset 131.5MYOC, OPTN
5primary congenital glaucoma31.4CYP1B1
6blindness31.2MYOC, WDR36, OPTN
7exfoliation syndrome31.0ELN, LOXL1
8hypertension11.3
9retinitis11.0
10cataract10.8
11myopia10.8
12low tension glaucoma10.7
13endotheliitis10.6
14ocular hypotension10.6
15residual stage of open angle glaucoma10.5
16choroiditis10.5
17neuropathy10.5
18glaucoma 1, open angle, e10.5
19alzheimer's disease10.5
20retinal vein occlusion10.5
21dementia10.5
22senile cataract10.5
23diabetic retinopathy10.4
24pulmonary hypertension10.4
25central retinal vein occlusion10.4
26primary pulmonary hypertension10.4
27kearns-sayre syndrome10.4
28nail-patella syndrome10.4
29glaucomatocyclitic crisis10.4
30cerebritis10.4
31thyroiditis10.4
32nevus of ota10.4
33proliferative vitreoretinopathy10.3TGFB2
34age related macular degeneration10.2
35atherosclerosis10.2
36ischemic optic neuropathy10.2
37keratoconus10.2
38keratopathy10.2
39ochronosis10.2
40marfan syndrome10.2
41neovascular glaucoma10.2
42juvenile glaucoma10.2
43waardenburg's syndrome10.2
44exophthalmos10.2
45degenerative myopia10.2
46neuroretinitis10.2
47cycloplegia10.2
48anisometropia10.2
49retinal lattice degeneration10.2
50vascular dementia10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Symptoms for Open-Angle Glaucoma

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Clinical features from OMIM:

137750,613100,609887

Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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MalaCards organs/tissues related to Open-Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Cortex, Retina, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Publications for Open-Angle Glaucoma

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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1050)
idTitleAuthorsYear
1
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
2
Open-angle glaucoma surgery: the current standing. (25295896)
2014
3
Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma. (25237590)
2014
4
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
5
Fixed combination of latanoprost and timolol vs the individual components for primary open angle glaucoma and ocular hypertension: a systematic review and meta-analysis. (25349811)
2014
6
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
7
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
8
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
9
Selective Laser Trabeculoplasty versus Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. (24367649)
2013
10
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
11
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
12
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
13
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
14
The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family. (23886590)
2013
15
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
16
Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. (23603758)
2013
17
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
18
Ocular rigidity, outflow facility, ocular pulse amplitude, and pulsatile ocular blood flow in open-angle glaucoma: a manometric study. (23761082)
2013
19
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension. (24180628)
2013
20
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
21
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
22
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
23
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
24
Primary open-angle glaucoma: everyone's business. (23520411)
2012
25
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
26
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
27
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
28
GSTM1 polymorphism in patients with primary open-angle glaucoma. (23079819)
2012
29
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
30
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
31
Five-year, multicenter safety study of fixed-combination latanoprost/timolol (Xalacom) for open-angle glaucoma and ocular hypertension. (20520568)
2011
32
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
33
Laser trabeculoplasty in the treatment of open-angle glaucoma. (21633246)
2011
34
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. (21743018)
2011
35
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
36
Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study. (20420586)
2010
37
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
38
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
39
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
40
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
41
Primary open-angle glaucoma. (19535810)
2009
42
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
43
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
44
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
45
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
46
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
47
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. (15216404)
2004
48
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
49
Molecular genetics of open-angle glaucoma, moving from gene localization to predictive testing. (10168351)
1997
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Expression patterns in normal tissues for genes affiliated with Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GSTM1, CYP1B1
2
Show member pathways
8.8ELN, LOXL1, TGFB2
3
Show member pathways
8.8ELN, LOXL1, TGFB2

Compounds for genes affiliated with Open-Angle Glaucoma

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Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1pyrene4410.1GSTM1, CYP1B1
21-hydroxypyrene4410.1GSTM1, CYP1B1
3phip4410.1CYP1B1, GSTM1
4cotinine44 2411.1CYP1B1, GSTM1
5aflatoxin b144 2411.1GSTM1, CYP1B1
6hydrocarbons4410.0GSTM1, CYP1B1
7benzene4410.0GSTM1, ELN
8deoxypyridinoline449.9ELN, TGFB2
9quinone44 2410.9CYP1B1, GSTM1
10tcdd449.9TGFB2, CYP1B1
11alginate449.9TGFB2, ELN
12epoxide449.8GSTM1, CYP1B1
13glycosaminoglycan449.8TGFB2, MYOC, ELN
14hyaluronic acid44 2410.8TGFB2, MYOC, ELN
15oxaliplatin44 50 1111.7GSTM1, CYP1B1
16valine449.7CYP1B1, ELN, GSTM1
17betacarotene449.7GSTM1, ELN
18benzo(a)pyrene449.7GSTM1, TGFB2, CYP1B1
19p003449.7GSTM1, TGFB2, CYP1B1
20ozone449.6GSTM1, ELN, TGFB2
21vitamin a44 24 1111.6GSTM1, ELN, TGFB2
225fluorouracil449.6CYP1B1, TGFB2, GSTM1
23n acetylcysteine449.6ELN, TGFB2, CYP1B1
24vitamin d449.5GSTM1, ELN, TGFB2
25doxycycline44 1110.5ELN, CYP1B1
26cycloheximide449.4ELN, MYOC, TGFB2, CYP1B1
27ascorbic acid44 2410.4TGFB2, MYOC, ELN, GSTM1
28testosterone44 61 24 1112.3GSTM1, ELN, TGFB2, CYP1B1
29genistein44 28 61 2 24 1114.2CYP1B1, TGFB2, ELN
30dexamethasone44 50 28 1112.1CYP1B1, TGFB2, MYOC, ELN, OPTN
31arginine449.1MYOC, ELN, NTF4, GSTM1
32estrogen449.1GSTM1, ELN, TGFB2, CYP1B1
33cysteine449.0TGFB2, MYOC, ELN, GSTM1
34glutamate448.9CYP1B1, TGFB2, ELN, NTF4
35retinoic acid44 249.8CYP1B1, TGFB2, ELN, NTF4

GO Terms for genes affiliated with Open-Angle Glaucoma

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Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.9LOXL1, MYOC, TGFB2

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.8MYOC, TGFB2
2blood vessel remodelingGO:0019749.5ELN, TGFB2
3extracellular matrix organizationGO:0301988.5ELN, LOXL1, TGFB2

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Open-Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet