MCID: OPN001
MIFTS: 56

Open-Angle Glaucoma malady

Eye diseases category

Summaries for Open-Angle Glaucoma

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46OMIM, 32MalaCards
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MalaCards: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to glaucoma and primary open angle glaucoma. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Naphthalene metabolism and Estrogen metabolism. The drugs epinephrine hydrochloride and epinephrine and the compounds vitamin a and cysteine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 613100,609887,137750

Aliases & Classifications for Open-Angle Glaucoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 46OMIM, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

open-angle glaucoma 8
open-angle glaucoma, unspecified 8
unspecified open-angle glaucoma 8
wide-angle glaucoma nos 8
open-angle glaucoma nos 8
glaucoma, open-angle 60
open angle glaucoma 8
pigmentary glaucoma 8
glaucoma open-angle 44
glaucoma simplex 8


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Disease Ontology8 DOID:1067
NCIt39 C34641
MeSH34 D005902
ICD1025 H40.1

Related Diseases for Open-Angle Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

Primary Open Angle Glaucoma open-angle glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.5TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
2primary open angle glaucoma32.4MYOC, RHO, OPTN, COCH, CYP1B1, ABCA4
3ocular hypertension31.9OPTN, MYOC
4retinitis31.3RHO
5primary angle-closure glaucoma31.3MYOC
6cataract31.1TGFB2, MYOC, RHO
7primary open angle glaucoma juvenile onset 130.9MYOC, CYP1B1
8primary congenital glaucoma30.7CYP1B1
9diabetic retinopathy30.5TGFB2, RHO
10eye disease30.2OPTN, RHO, MYOC, ABCA4, TGFB2
11age related macular degeneration30.2RHO
12hypertension11.3
13juvenile glaucoma11.0
14myopia10.7
15low tension glaucoma10.7
16exfoliation syndrome10.7
17residual stage of open angle glaucoma10.5
18neuropathy10.5
19ocular hypotension10.5
20glaucoma 1, open angle, e10.5
21choroiditis10.4
22retinal vein occlusion10.4
23senile cataract10.4
24primary pulmonary hypertension10.3
25nail-patella syndrome10.3
26glaucomatocyclitic crisis10.3
27kearns-sayre syndrome10.3
28central retinal vein occlusion10.3
29alzheimer's disease10.3
30dementia10.3
31thyroiditis10.3
32pigment-dispersion syndrome10.2
33ischemic retinopathy10.2
34marfan syndrome10.2
35steroid-induced glaucoma - borderline10.2
36neovascular glaucoma10.2
37neuroretinitis10.2
38cycloplegia10.2
39lens subluxation10.2
40anisometropia10.2
41cerebritis10.2
42retinal lattice degeneration10.2
43bullous keratopathy10.2
44exudative vitreoretinopathy10.2
45ischemic neuropathy10.2
46exophthalmos10.2
47waardenburg's syndrome10.2
48degenerative myopia10.2
49diabetic cataract10.2
50ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Clinical Features for Open-Angle Glaucoma

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Sources:
46OMIM
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Clinical features from OMIM:

613100,609887,137750

Drugs & Therapeutics for Open-Angle Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Open-Angle Glaucoma

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Anatomical Context for Open-Angle Glaucoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Open-Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Cortex, Retina, Thyroid

Animal Models for Open-Angle Glaucoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Open-Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.7TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Open-Angle Glaucoma

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Sources:
50PubMed
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Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1043)
idTitleAuthorsYear
1
Changes in the lamina and prelamina after intraocular pressure reduction in patients with primary open-angle glaucoma and acute primary angle-closure. (24204049)
2014
2
Correlation of visual functions with macular thickness in primary open angle glaucoma. (24082667)
2013
3
Mitochondrial genome analysis of primary open angle glaucoma patients. (23940637)
2013
4
Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. (23831221)
2013
5
Morphology of optic disc through heidelberg retina tomograph in retinal vein occlusions alone or in combination with primary open angle glaucoma. (23961303)
2013
6
Corneal Biomechanical Properties Affect Goldmann Applanation Tonometry in Primary Open-angle Glaucoma. (23603825)
2013
7
The influence of retinal blood flow on open-angle glaucoma in patients with and without diabetes. (24366767)
2013
8
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
9
Common TGFI^2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. (22736943)
2012
10
Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma. (22840486)
2012
11
Influence of rheological factors on the development of primary open angle glaucoma. (23346803)
2012
12
Longitudinal trends in resource use in an incident cohort of open-angle glaucoma patients: resource use in open-angle glaucoma. (22789564)
2012
13
Optic disc fluorescein leakage and intraocular pressure in primary open-angle glaucoma. (22577769)
2012
14
The effects of moxaverine on ocular blood flow in patients with age-related macular degeneration or primary open angle glaucoma and in healthy control subjects. (20456253)
2012
15
Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis. (22902176)
2012
16
Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. (22328638)
2012
17
Relationship of intraocular pressure and frequency of spontaneous retinal venous pulsation in primary open-angle glaucoma. (22980741)
2012
18
Five-year, multicenter safety study of fixed-combination latanoprost/timolol (Xalacom) for open-angle glaucoma and ocular hypertension. (20520568)
2011
19
Effect of brimonidine on retinal blood flow autoregulation in primary open-angle glaucoma. (21631365)
2011
20
The association between primary open-angle glaucoma and motor vehicle collisions. (21447677)
2011
21
Tafluprost for the reduction of interocular pressure in open angle glaucoma and ocular hypertension. (23861619)
2011
22
The influence of surgical and medical interventions upon optic disc structure in patients with primary open angle glaucoma. (22187300)
2011
23
Long-term outcomes of prostaglandin analog versus timolol maleate in ocular hypertensive or primary open-angle glaucoma patients in Europe. (21790326)
2011
24
Correlation of optic disc morphology and ocular perfusion parameters in patients with primary open angle glaucoma. (21599872)
2011
25
Comparing corneal variables in healthy subjects and patients with primary open-angle glaucoma. (21296827)
2011
26
AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. (20101282)
2010
27
Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (20376328)
2010
28
Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas. (20808730)
2010
29
Comparative biometric study between plateau iris configuration and primary open angle glaucoma with narrow angle. (19668957)
2009
30
Autosomal recessive primary open angle glaucoma (POAG) in beagles is not associated with mutations in the myocilin (MYOC) gene. (19225800)
2009
31
Comparison of one-site versus two-site phacotrabeculectomy without the use of antimetabolites intraoperatively in patients with pseudoexfoliation glaucoma and primary open-angle glaucoma. (19668582)
2009
32
Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18721251)
2008
33
Comparisons of Medical, Laser, and Incisional Surgical Treatments for Open-Angle Glaucoma in Adults (23556149)
2007
34
Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. (17524782)
2007
35
A randomized, crossover, open label pilot study to evaluate the efficacy and safety of Xalatan in comparison with generic Latanoprost (Latoprost) in subjects with primary open angle glaucoma or ocular hypertension. (17322603)
2007
36
Investigation on the mutation of MYOC gene in two family pedigrees with primary open-angle glaucoma in Shanxi]. (17867509)
2007
37
Myocilin variants in Indian patients with open-angle glaucoma. (17562996)
2007
38
Patients' and physicians' perceptions of the travoprost dosing aid: an open-label, multicenter study of adherence with prostaglandin analogue therapy for open-angle glaucoma or ocular hypertension. (17213000)
2006
39
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma. (16862072)
2006
40
Confirmation of the adult-onset primary open angle glaucoma locus GLC1B at 2cen-q13 in an Australian family. (16374045)
2006
41
SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (17122126)
2006
42
The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region. (16966629)
2006
43
Evaluation of Optineurin as a candidate gene in Indian patients with primary open angle glaucoma. (16205626)
2005
44
CYP1B1 mutations in French patients with early-onset primary open- angle glaucoma. (15342693)
2004
45
Beta 2-adrenergic receptor polymorphism and susceptibility to primary congenital and primary open angle glaucoma. (13680034)
2003
46
Group II phospholipase A2 content of tears in patients with senile cataract and primary open-angle glaucoma. (11936442)
2002
47
Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma. (10798654)
2000
48
The prevalence of primary angle closure glaucoma and open angle glaucoma in Mamre, western Cape, South Africa. (8363470)
1993
49
Postural change of IOP in normal persons and in patients with primary wide open-angle glaucoma and low-tension glaucoma. (6722071)
1984
50
Open angle glaucoma, ocular hypertension, low-tension glaucoma, and refraction. (7115175)
1982

Genetic Variations for Open-Angle Glaucoma

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Expression for genes affiliated with Open-Angle Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN
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Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Naphthalene metabolism
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10.6GSTM1, CYP1B1
2
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10.6GSTM1, CYP1B1
3
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10.6TGFB2, ELN
4
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10.6TGFB2, ELN

Compounds for genes affiliated with Open-Angle Glaucoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2413.0TGFB2, ELN, GSTM1, ABCA4, RHO
2cysteine4410.9COCH, RHO, MYOC, GSTM1, ELN, TGFB2
3valine4410.9ELN, GSTM1, CYP1B1, RHO
4ozone4410.9GSTM1, ELN, TGFB2
5benzo(a)pyrene4410.9CYP1B1, GSTM1, TGFB2
6ascorbic acid44 2411.9MYOC, GSTM1, ELN, TGFB2
7betacarotene4410.9ELN, GSTM1, RHO
8pyrene4410.8GSTM1, CYP1B1
91-hydroxypyrene4410.7GSTM1, CYP1B1
10glycosaminoglycan4410.7MYOC, ELN, TGFB2
1111-cis-retinol44 2411.7ABCA4, RHO
12dexamethasone44 49 28 1113.7OPTN, MYOC, CYP1B1, ELN, TGFB2
13p0034410.7TGFB2, GSTM1, CYP1B1
14arginine4410.6RHO, NTF4, MYOC, GSTM1, ELN
15cotinine44 2411.6GSTM1, CYP1B1
16phip4410.3GSTM1, CYP1B1

GO Terms for genes affiliated with Open-Angle Glaucoma

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16Gene Ontology
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Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.6ABCA4, RHO

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Open-Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Open-Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet