MCID: OPN001
MIFTS: 51

Open-Angle Glaucoma malady

Eye category

Summaries for Open-Angle Glaucoma

Sources:
47OMIM, 33MalaCards
See all sources

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MalaCards: Open-Angle Glaucoma, also known as open-angle glaucoma, unspecified, is related to primary open angle glaucoma and ocular hypertension. An important gene associated with Open-Angle Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Naphthalene metabolism and Estrogen metabolism. The drugs epinephrine hydrochloride and betaxolol and the compounds vitamin a and cysteine have been mentioned in the context of this disorder. Related mouse phenotype vision/eye.

Description from OMIM:47 613100,609887,137750

Aliases & Classifications for Open-Angle Glaucoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 47OMIM, 40NCIt, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

open-angle glaucoma 8
open-angle glaucoma, unspecified 8
unspecified open-angle glaucoma 8
wide-angle glaucoma nos 8
open-angle glaucoma nos 8
glaucoma, open-angle 61
open angle glaucoma 8
pigmentary glaucoma 8
glaucoma open-angle 45
glaucoma simplex 8


External Ids:

Disease Ontology8 DOID:1067
NCIt40 C34641
MeSH35 D005902
ICD1025 H40.1

Related Diseases for Open-Angle Glaucoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Open-Angle Glaucoma family:

primary open angle glaucoma primary open angle glaucoma juvenile onset 1
glaucoma 1a, primary open angle glaucoma 3a, primary open angle, congenital, juvenile, or adult onset
glaucoma 1b, primary open angle, adult onset glaucoma 1c, primary open angle
glaucoma 1d, primary open angle glaucoma, primary open angle, juvenile-onset, 2
glaucoma 1, open angle, p glaucoma 1, open angle, i
glaucoma 1, open angle, 1o glaucoma 1k, primary open angle, juvenile-onset

Diseases related to Open-Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1primary open angle glaucoma32.4ABCA4, TGFB2, ELN, GSTM1, CYP1B1, MYOC
2ocular hypertension31.9OPTN, MYOC
3primary open angle glaucoma juvenile onset 131.0MYOC, CYP1B1
4blindness30.7ABCA4, WDR36, RHO, OPTN, MYOC
5primary congenital glaucoma30.7CYP1B1
6juvenile glaucoma11.0
7glaucoma 1, open angle, g10.8
8cataract-glaucoma10.8
9glaucoma 1, open angle, p10.7
10exfoliation syndrome10.7
11glaucoma 1, open angle, e10.6
12glaucoma 1, open angle, m10.6
13n syndrome10.5
14residual stage of open angle glaucoma10.5
15glaucoma, congenital10.5
16early-onset glaucoma10.5
17h. pylori infection10.5
18glaucoma 1, open angle, f10.5
19glaucoma 1, open angle, i10.4
20primary pulmonary hypertension10.3
21nail-patella syndrome10.3
22glaucomatocyclitic crisis10.3
23kearns-sayre syndrome10.3
24central retinal vein occlusion10.3
25say syndrome10.3
26ischemic retinopathy10.2
27marfan syndrome10.2
28neovascular glaucoma10.2
29cycloplegia10.2
30lens subluxation10.2
31anisometropia10.2
32retinal lattice degeneration10.2
33bullous keratopathy10.2
34exudative vitreoretinopathy10.2
35ischemic neuropathy10.2
36exophthalmos10.2
37waardenburg's syndrome10.2
38degenerative myopia10.2
39leber hereditary optic neuropathy10.2
40diabetic cataract10.2
41ischemic optic neuropathy10.2
42ochronosis10.2
43astigmatism10.2
44atherosclerosis10.2
45steroid-induced glaucoma10.2
46char syndrome10.2
47congenital stromal corneal dystrophy10.2
48cogan's syndrome10.2
49cogan-reese syndrome10.2
50encephalomyopathy10.2

Graphical network of the top 20 diseases related to Open-Angle Glaucoma:



Diseases related to open-angle glaucoma

Clinical Features for Open-Angle Glaucoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

613100,609887,137750

Drugs & Therapeutics for Open-Angle Glaucoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Open-Angle Glaucoma

Anatomical Context for Open-Angle Glaucoma

Animal Models for Open-Angle Glaucoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Open-Angle Glaucoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.7TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Open-Angle Glaucoma

Sources:
51PubMed
See all sources

Articles related to Open-Angle Glaucoma:

(show top 50)    (show all 1043)
idTitleAuthorsYear
1
Genetics of primary open angle glaucoma. (24258795)
2014
2
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
3
Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma. (23860758)
2013
4
Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. (23441116)
2013
5
Comparative effectiveness of treatments for open-angle glaucoma: a systematic review for the U.S. Preventive Services Task Force. (23420235)
2013
6
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology. (24055863)
2013
7
Reduced cerebrovascular reactivity in posterior cerebral arteries in patients with primary open-angle glaucoma. (23816432)
2013
8
Comparison of resource utilization in the treatment of open-angle glaucoma between two cities in Finland: is more better? (23621767)
2013
9
Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma. (23142105)
2013
10
New mutation in the myocilin gene segregates with juvenile-onset open-angle glaucoma in a Brazilian family. (23566828)
2013
11
Long-term medical management of primary open-angle glaucoma and ocular hypertension in the UK: optimizing cost-effectiveness and clinic resources by minimizing therapy switches. (21677590)
2012
12
Primary Open-Angle Glaucoma: A Transforming Growth Factor-I^ Pathway-Mediated Disease. (22525463)
2012
13
Open-angle glaucoma in patients with diabetic retinopathy at the Puerto Rico Medical Center. (23763217)
2012
14
The proapoptotic p53 (C72G) and p21 (C31A) polymorphisms as the risk factors for the development of primary open-angle glaucoma in Transbaikalian region]. (23210340)
2012
15
Author response: incident open-angle glaucoma and ocular perfusion pressure. (22253362)
2012
16
Clinical application of photopic negative response of the flash electroretinogram in primary open-angle Glaucoma. (22993054)
2012
17
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
18
Comparison of selective laser trabeculoplasty (SLT) in primary open angle glaucoma and pseudoexfoliation glaucoma. (22069348)
2011
19
Substance use disorder and the risk of open-angle glaucoma. (21278592)
2011
20
Long-term results of primary trabeculectomies and Molteno implants for primary open-angle glaucoma. (21746973)
2011
21
The effect of different criteria on the number of patients blind from open-angle glaucoma. (22074185)
2011
22
A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension. (21851167)
2011
23
Identification of a novel locus for autosomal dominant primary open angle glaucoma on 4q35.1-q35.2. (21896847)
2011
24
Elevated serum immunoglobulin G titers against Chlamydia pneumoniae in primary open-angle glaucoma patients without systemic disease. (20164795)
2010
25
No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. (20215012)
2010
26
Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. (20357201)
2010
27
Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma. (21139974)
2010
28
The cost-effectiveness of routine office-based identification and subsequent medical treatment of primary open-angle glaucoma in the United States. (19285730)
2009
29
Comparative studies of RNFL thickness measured by OCT with global index of visual fields in patients with ocular hypertension and early open angle glaucoma. (19668593)
2009
30
Red blood cell plasmalogens and docosahexaenoic acid are independently reduced in primary open-angle glaucoma. (19627986)
2009
31
A study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to latanoprost 0.005% and timolol 0.5% dosed concomitantly in patients with open-angle glaucoma or ocular hypertension. (19668722)
2008
32
Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma. (18385781)
2008
33
Transforming growth factor beta-1 -509C>T polymorphism in Indian patients with primary open angle glaucoma. (17570736)
2007
34
Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese. (17960130)
2007
35
A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q. (17122119)
2006
36
Novel myocilin mutation in a Chinese family with juvenile-onset open- angle glaucoma. (16401791)
2006
37
Evaluation of the association between OPA1 polymorphisms and primary open-angle glaucoma in Barbados families. (16785854)
2006
38
Bimatoprost: a pharmacoeconomic review of its use in open-angle glaucoma and ocular hypertension. (16519552)
2006
39
Comparison of the efficacy and safety of travoprost with a fixed-combination of dorzolamide and timolol in patients with open-angle glaucoma or ocular hypertension. (16968583)
2006
40
Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. (16157798)
2005
41
Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. (15914614)
2005
42
Mutations and polymorphisms in the genes for myocilin and optineur in as the risk factors of primary open-angle glaucoma]. (16358725)
2005
43
Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma. (15650607)
2005
44
Clinical features associated with mutations in the chromosome 1 open- angle glaucoma gene. (9535666)
1998
45
Association study of the 5' flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma. (9493554)
1998
46
Novel trabecular meshwork inducible glucocorticoid response mutation in an eight-generation juvenile-onset primary open-angle glaucoma pedigree. (9754180)
1998
47
A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma. (9832047)
1998
48
Spectrometric investigations in ocular hypertension and early stages of primary open angle glaucoma and of low tension glaucoma--multisubstance analysis. (1428553)
1992
49
Finger blood flow in patients with low tension glaucoma and primary open-angle glaucoma. (1739685)
1992
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Genetic Variations for Open-Angle Glaucoma

Expression for genes affiliated with Open-Angle Glaucoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Open-Angle Glaucoma

Search GEO for disease gene expression data for Open-Angle Glaucoma.

Pathways for genes affiliated with Open-Angle Glaucoma

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 52QIAGEN
See all sources

Pathways related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Naphthalene metabolism
Hide members
10.6GSTM1, CYP1B1
2
Hide members
10.6GSTM1, CYP1B1
3
Hide members
10.6TGFB2, ELN
4
Hide members
10.6TGFB2, ELN

Compounds for genes affiliated with Open-Angle Glaucoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1vitamin a45 11 2413.0RHO, ABCA4, GSTM1, ELN, TGFB2
2cysteine4510.9COCH, RHO, MYOC, GSTM1, ELN, TGFB2
3valine4510.9ELN, GSTM1, CYP1B1, RHO
4ozone4510.9TGFB2, GSTM1, ELN
5benzo(a)pyrene4510.9CYP1B1, GSTM1, TGFB2
6ascorbic acid45 2411.9TGFB2, ELN, MYOC, GSTM1
7betacarotene4510.9RHO, ELN, GSTM1
8pyrene4510.8GSTM1, CYP1B1
91-hydroxypyrene4510.7GSTM1, CYP1B1
10glycosaminoglycan4510.7MYOC, ELN, TGFB2
1111-cis-retinol45 2411.7ABCA4, RHO
12dexamethasone45 50 29 1113.7ELN, TGFB2, CYP1B1, MYOC, OPTN
13p0034510.7CYP1B1, GSTM1, TGFB2
14arginine4510.6ELN, GSTM1, MYOC, NTF4, RHO
15cotinine45 2411.6GSTM1, CYP1B1
16phip4510.3GSTM1, CYP1B1

GO Terms for genes affiliated with Open-Angle Glaucoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.6ABCA4, RHO

Biological processes related to Open-Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Open-Angle Glaucoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Open-Angle Glaucoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet