MCID: OPT003
MIFTS: 55

Opiate Dependence malady

Mental diseases category
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Summaries for Opiate Dependence

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards: Opiate Dependence, also known as opioid dependence, is related to drug dependence and substance abuse. An important gene associated with Opiate Dependence is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Melanocyte Development and Pigmentation and p38 signaling mediated by MAPKAP kinases. The compounds quinpirole and gamma-butyrolactone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:65 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Description from OMIM:47 610064

Aliases & Classifications for Opiate Dependence

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8Disease Ontology, 10DISEASES, 47OMIM, 45Novoseek, 58SNOMED-CT, 27ICD9CM, 35MeSH, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

opiate dependence 8 10
opioid dependence 47 45
opioid type dependence 8


External Ids:

Disease Ontology8 DOID:2559
ICD9CM27 304.0, 304.00
MeSH35 D009293

Related Diseases for Opiate Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1drug dependence30.4DRD3, OPRM1
2substance abuse30.4DRD3, OPRM1
3hyperglycemia30.2IGF1, POMC, CREB1
4panic disorder30.2CCKBR, POMC
5schizophrenia30.0TH, NGF, CCKBR, CREB1, DRD3, OPRM1
6neuronitis10.3
7alcohol dependence10.3
8attention deficit hyperactivity disorder10.3
9conduct disorder10.3
10hepatitis c10.2
11hepatitis10.2
12blindness10.2
13neonatal abstinence syndrome10.2
14chronic pain10.2
15opioid dependence 110.2
16opioid abuse10.1NPFF
17cerebral hypoxia10.1CREB1
18diabetic autonomic neuropathy10.1NGF
19hyperaldosteronism10.1TH, POMC
20morphine dependence10.1
21borderline personality disorder10.1
22heroin dependence10.1
23premature ejaculation10.1
24cerebritis10.1
25sudden infant death syndrome10.1
26anxiety disorder10.1
27personality disorder10.1
28pertussis10.1
29hepatitis c virus10.1
30endotheliitis10.1
31craniopharyngioma10.1POMC, IGF1
32sheehan syndrome10.1POMC, IGF1
33gonadal disease10.1IGF1, POMC
34bipolar disorder10.1TH, CREB1
35thyrotropin deficiency, isolated10.1POMC, IGF1
36pituitary gland disease10.1IGF1, POMC
37withdrawal disorder10.1NPFF, OPRM1
38movement disease10.1DRD3, TH
39panhypopituitarism10.1IGF1, POMC
40substance dependence10.1DRD3, OPRM1
41amenorrhea10.1IGF1, POMC
42rett syndrome10.1TH, NGF
43age related macular degeneration10.1VEGFA
44growth hormone deficiency10.1IGF1, POMC
45precocious puberty10.1IGF1, POMC
46leydig cell tumor10.1POMC, CREB1
47hypopituitarism10.1IGF1, POMC
48addison's disease10.1POMC, TH
49idiopathic generalized epilepsy10.1ME2
50thyroid medullary carcinoma10.1CREB1, CCKBR, POMC

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Symptoms for Opiate Dependence

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47OMIM
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Clinical features from OMIM:

610064

Drugs & Therapeutics for Opiate Dependence

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Genetic Tests for Opiate Dependence

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Anatomical Context for Opiate Dependence

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33MalaCards
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MalaCards organs/tissues related to Opiate Dependence:

33
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Opiate Dependence:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9OPRM1, DRD3, POMC, IGF1
2MP:00053678.4IGF1, VEGFA, POMC, CCKBR, DRD3
3MP:00030128.0TH, NGF, VEGFA, POMC, OPRM1
4MP:00028737.8TH, IGF1, NGF, VEGFA, CREB1, OPRM1
5MP:00053797.7TH, IGF1, VEGFA, POMC, CCKBR, CREB1
6MP:00107717.6TH, IGF1, NGF, VEGFA, POMC, CCKBR
7MP:00053857.6TH, IGF1, NGF, VEGFA, POMC, CCKBR
8MP:00053867.4TH, NGF, VEGFA, POMC, CCKBR, CREB1
9MP:00107687.2TH, IGF1, NGF, VEGFA, POMC, CREB1
10MP:00036317.1OPRM1, TH, IGF1, NGF, VEGFA, POMC
11MP:00053787.1TH, IGF1, NGF, VEGFA, POMC, CCKBR
12MP:00053767.0TH, IGF1, NGF, VEGFA, POMC, CCKBR

Publications for Opiate Dependence

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52PubMed
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Articles related to Opiate Dependence:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. (24205275)
2013
2
Relative and age-dependent stimulation of soluble and cellular immunity in opiate dependence. (21918466)
2012
3
Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. (21920671)
2012
4
Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence. (19327850)
2011
5
The effect of pain on stroop performance in patients with opiate dependence in sustained remission. (21769047)
2011
6
Factors associated with the prescribing of buprenorphine or methadone for treatment of opiate dependence. (19004598)
2009
7
Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. (19608356)
2009
8
Economic evaluation of interventions to treat opiate dependence : a review of the evidence. (18429655)
2008
9
The neuropsychology of amphetamine and opiate dependence: implications for treatment. (17690986)
2007
10
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
11
Suicidal ideation in veterans receiving treatment for opiate dependence. (16903454)
2006
12
Profile of executive and memory function associated with amphetamine and opiate dependence. (16160707)
2006
13
Maternal deprivation specifically enhances vulnerability to opiate dependence. (17110797)
2006
14
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
15
Public policy statement on buprenorphine for opiate dependence and withdrawal. (15534969)
2004
16
Diamorphine treatment for opiate dependence: putative markers of concomitant heroin misuse. (11900600)
2001
17
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. (11122350)
2000
18
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (9702742)
1998
19
An open trial of naltrexone for opiate dependence. (16203482)
1998
20
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
21
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. (9315909)
1997
22
Decreased nociceptive sensitivity: a biological risk marker for opiate dependence? (9158227)
1997
23
Management of opiate dependence. (8745858)
1996
24
Use of morphine mixture to stabilize opiate dependence. (16203402)
1996
25
Opiate dependence, comorbidity and seasonality of birth. (8555277)
1995
26
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
27
A Markov model for NIDA data on treatment of opiate dependence. (1436013)
1992
28
Nasal administration of naloxone for detection of opiate dependence. (1560408)
1992
29
Analysis of clinical trials for treatment of opiate dependence: what are the possibilities? (1436010)
1992
30
Neurobiological mechanisms in cocaine and opiate dependence. (1311123)
1992
31
Statistical Issues in Clinical Trials for Treatment of Opiate Dependence. Technical review. Bethesda, Maryland, December 2-3, 1991. (1436009)
1992
32
New trends in infant pain management: potential for opiate dependence. (1876111)
1990
33
Discrimination of opiate dependence from opiate abstinence and methadone maintenance by use of the Derogatis scale. (3406052)
1988
34
The opiate dependence syndrome: replication study using the SODQ in a New York clinic. (3207935)
1988
35
Naltrexone in the treatment of opiate dependence. (3580701)
1987
36
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (2874232)
1986
37
The effect of tolerance on opiate dependence as measured by the adenylate cyclase rebound response to naloxone in the NG108-15 model system. (6099517)
1984
38
Physiological basis of opiate dependence. (6851851)
1983
39
Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence. (6126814)
1982
40
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
41
Propoxyphene napsylate compared to methadone for opiate dependence. (6122232)
1981
42
Recent trends in opiate dependence. (435878)
1979
43
Recent trends in opiate dependence. (455022)
1979
44
Agonist--antagonist properties of phenoxybenzamine in antinociception and opiate dependence tests. (572775)
1979
45
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
46
Naltrexone in the treatment of opiate dependence. (218108)
1978
47
Trends in methadone use in the treatment of opiate dependence in Canada. (872016)
1977
48
Prostaglandins, cyclic AMP and the mechanism of opiate dependence. (167256)
1975
49
Naloxone treatment of opiate dependence. A progress report. (5108223)
1971
50
Narcotic antagonists in opiate dependence. (4914724)
1970

Variations for Opiate Dependence

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Expression for genes affiliated with Opiate Dependence

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opiate Dependence

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 30KEGG, 5Cell Signaling Technology, 12EMD Millipore
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Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CREB1, POMC
29.8CREB1, TH
39.7CREB1, NGF
4
Show member pathways
9.6POMC, VEGFA
59.0CREB1, VEGFA, IGF1
6
Show member pathways
Signaling Pathways in Glioblastoma38
9.0IGF1, VEGFA, CREB1
79.0VEGFA, NGF, IGF1
8
Show member pathways
9.0TH, CREB1, DRD3, OPRM1
9
Show member pathways
8.9CCKBR, CREB1, NPFF
10
Show member pathways
8.9OPRM1, CREB1, POMC, NGF
118.9TH, NGF, CREB1, OPRM1
12
Show member pathways
Peptide GPCRs38
8.8NPFF, OPRM1, CCKBR
138.7TH, NGF, VEGFA, CREB1
148.6CREB1, VEGFA, NGF, IGF1
15
Show member pathways
8.2POMC, CCKBR, DRD3, OPRM1, NPFF
16
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.1IGF1, NGF, VEGFA, CREB1, OPRM1
17
Show member pathways
6.3NPFF, IGF1, NGF, VEGFA, POMC, CCKBR

Compounds for genes affiliated with Opiate Dependence

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1quinpirole45 2910.8DRD3, CREB1, TH
2gamma-butyrolactone459.8TH, DRD3
3heroin45 51 1111.7DRD3, POMC, OPRM1
4yohimbine45 3 29 1112.6OPRM1, DRD3, CCKBR
5methadone51 45 1111.5OPRM1, NGF, POMC
6naltrexone45 29 51 1112.5POMC, IGF1, OPRM1
7desipramine45 51 1111.5CREB1, NGF, TH
8bromocriptine45 29 1111.5CREB1, IGF1, POMC, DRD3
9mptp459.5TH, DRD3, NGF
10naloxone45 29 51 1112.4POMC, CREB1, OPRM1
11valproate459.4CREB1, IGF1, TH
12amphetamine45 51 1111.4CCKBR, OPRM1, POMC, TH
13methamphetamine45 51 1111.4TH, CREB1, DRD3, OPRM1
14chelerythrine459.4IGF1, CREB1, OPRM1
15deltorphin i459.3NPFF, OPRM1
165-hydroxytryptamine459.3OPRM1, CREB1, POMC, TH
17acth459.2IGF1, CCKBR, CREB1, POMC
18octreotide45 61 29 1112.2POMC, CCKBR, VEGFA, IGF1
19progestin459.1POMC, VEGFA, IGF1, TH
20gaba459.1POMC, TH, ME2, CREB1, OPRM1
21nicotine45 29 51 1112.0DRD3, CCKBR, NGF, TH, OPRM1
226-hydroxydopamine459.0NGF, CREB1, TH, DRD3, OPRM1
23epinephrine45 24 1110.9TH, NGF, POMC, CREB1, OPRM1
24clonidine45 51 29 1111.9IGF1, OPRM1, POMC
25gf 109203x45 619.9VEGFA, OPRM1, NGF, CREB1
26histamine45 29 2410.9CCKBR, TH, CREB1, OPRM1, NGF
27tetrapeptide458.8OPRM1, NPFF, CCKBR
28haloperidol45 51 29 3 1112.8POMC, OPRM1, DRD3, TH, CREB1, CCKBR
29norepinephrine45 24 1110.7CREB1, DRD3, OPRM1, POMC, NGF, TH
30nmda45 299.7OPRM1, DRD3, TH, CREB1, CCKBR, NGF
31actinomycin d458.6IGF1, NGF, VEGFA, CREB1, TH
32sb 20358045 619.6IGF1, NGF, VEGFA, CCKBR, CREB1
33acetylcholine45 51 29 24 1112.6CCKBR, OPRM1, CREB1, POMC, NGF, TH
34adenylate458.6TH, OPRM1, POMC, NGF, CCKBR, CREB1
35levodopa45 119.6DRD3, NGF, IGF1, TH, CREB1, OPRM1
36glutamate458.5OPRM1, TH, NGF, CCKBR, CREB1, DRD3
37gnrh458.5TH, IGF1, NGF, POMC, CREB1, OPRM1
38cycloheximide458.5IGF1, POMC, NGF, VEGFA, CREB1
39testosterone45 61 24 1111.5NGF, CREB1, OPRM1, POMC, IGF1, TH
40cocaine45 119.4NGF, OPRM1, DRD3, CREB1, CCKBR, POMC
41vegf458.3VEGFA, TH, CREB1, IGF1, NGF, POMC
42opiate458.3CREB1, TH, POMC, NPFF, OPRM1, DRD3
43ly294002458.2OPRM1, TH, CREB1, IGF1, NGF, VEGFA
44glutamine458.2TH, IGF1, NGF, POMC, CCKBR, OPRM1
45cyclic amp45 249.1TH, NPFF, OPRM1, DRD3, CREB1, NGF
46morphine45 51 29 1111.1CREB1, CCKBR, NPFF, NGF, TH, OPRM1
47serine458.1POMC, CREB1, CCKBR, IGF1, NGF, DRD3
48dopamine45 29 24 1110.9IGF1, NGF, POMC, CCKBR, CREB1, DRD3
49dexamethasone45 51 29 1110.9VEGFA, TH, OPRM1, CREB1, POMC, IGF1
50tyrosine457.9DRD3, CREB1, VEGFA, NGF, IGF1, TH

GO Terms for genes affiliated with Opiate Dependence

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16Gene Ontology
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Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9NGF, VEGFA, POMC, NPFF, IGF1
2extracellular spaceGO:0056157.6NPFF, POMC, VEGFA, NGF, IGF1

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:00196310.2TH, DRD3
2response to amphetamineGO:00197510.0TH, DRD3
3response to electrical stimulusGO:05160210.0NGF, TH
4adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.0OPRM1, DRD3
5Type I pneumocyte differentiationGO:06050910.0IGF1, CREB1
6regulation of multicellular organism growthGO:04001410.0DRD3, IGF1
7sensory perceptionGO:00760010.0OPRM1, CCKBR
8positive regulation of mitosisGO:0458409.9IGF1, DRD3
9social behaviorGO:0351769.9TH, DRD3
10negative regulation of adenylate cyclase activityGO:0071949.9DRD3, OPRM1
11eye photoreceptor cell developmentGO:0424629.8VEGFA, TH
12positive regulation of protein autophosphorylationGO:0319549.8VEGFA, NGF
13response to peptide hormoneGO:0434349.7NGF, TH
14extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7NGF, IGF1
15locomotory behaviorGO:0076269.7OPRM1, DRD3, TH
16heart morphogenesisGO:0030079.7VEGFA, TH
17response to morphineGO:0432789.6NPFF, DRD3
18branching morphogenesis of an epithelial tubeGO:0487549.6IGF1, VEGFA
19phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.6CCKBR, OPRM1
20learningGO:0076129.6DRD3, TH
21phosphatidylinositol-mediated signalingGO:0480159.5IGF1, NGF, CREB1
22lactationGO:0075959.4CREB1, VEGFA
23neuropeptide signaling pathwayGO:0072189.2POMC, OPRM1, NPFF
24positive regulation of cytosolic calcium ion concentrationGO:0072049.1NPFF, OPRM1, CCKBR
25positive regulation of cell proliferationGO:0082849.1DRD3, CCKBR, VEGFA, IGF1
26response to drugGO:0424939.0NPFF, NGF, CREB1, DRD3
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IGF1, VEGFA, POMC, CREB1, DRD3

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8DRD3, TH
2G-protein coupled receptor bindingGO:0016649.4NPFF, POMC
3growth factor activityGO:0080838.7VEGFA, NGF, IGF1

Products for genes affiliated with Opiate Dependence

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Sources for Opiate Dependence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet