MCID: OPT003
MIFTS: 44

Opiate Dependence malady

Summaries for Opiate Dependence

About this section


Disease Ontology:9 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards based summary: Opiate Dependence, also known as opioid type dependence, is related to hyperglycemia and alcohol dependence. An important gene associated with Opiate Dependence is DRD3 (dopamine receptor D3), and among its related pathways are Melanocyte Development and Pigmentation and p38 signaling mediated by MAPKAP kinases. The compounds gamma-butyrolactone and quinpirole have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Opiate Dependence

About this section

Opiate Dependence, Aliases & Descriptions:

Name: Opiate Dependence 9 11
Opioid Type Dependence 9
 
Opiate Addiction 60


External Ids:

Disease Ontology9 DOID:2559
MeSH33 D009293
ICD9CM27 304.0, 304.00

Related Diseases for Opiate Dependence

About this section

Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1hyperglycemia30.1IGF1, POMC, CREB1
2alcohol dependence30.0NGF, POMC, CCKBR, DRD3, OPRM1
3schizophrenia29.5TH, NGF, CCKBR, CREB1, DRD3, OPRM1
4opioid abuse10.5NPFF
5cerebral hypoxia10.4CREB1
6diabetic autonomic neuropathy10.4NGF
7macular degeneration, age-related, 110.3VEGFA
8neuronitis10.3
9hyperaldosteronism10.3TH, POMC
10movement disease10.3TH, DRD3
11neurotic disorder10.3TH, CREB1
12panic disorder10.3POMC, CCKBR
13craniopharyngioma10.3IGF1, POMC
14hepatitis10.2
15hepatitis c10.2
16blindness10.2
17sheehan syndrome10.2POMC, IGF1
18addison's disease10.2POMC, TH
19gonadal disease10.2IGF1, POMC
20leydig cell tumor10.2CREB1, POMC
21hypothryoidism, congenital, nongoitrous 410.2POMC, IGF1
22pituitary gland disease10.2POMC, IGF1
23rett syndrome10.2TH, NGF
24pituitary hormone deficiency, combined, 210.2IGF1, POMC
25amenorrhea10.2POMC, IGF1
26growth hormone deficiency10.2IGF1, POMC
27precocious puberty10.2IGF1, POMC
28hypopituitarism10.2IGF1, POMC
29withdrawal disorder10.2NPFF, OPRM1
30opioid dependence10.2OPRM1, DRD3
31adrenocortical carcinoma10.2CREB1, POMC
32bipolar disorder10.2TH, CREB1, DRD3
33substance dependence10.2DRD3, OPRM1
34drug dependence10.1DRD3, OPRM1
35medullary thyroid carcinoma, familial10.1POMC, CCKBR, CREB1
36exudative vitreoretinopathy 110.1IGF1, VEGFA
37ganglioneuroma10.1TH, NGF, POMC
38parkinson disease, late-onset10.1DRD3, NGF, TH
39substance abuse10.1DRD3, OPRM1
40adrenal cortical adenoma10.1CREB1, POMC
41factor vii deficiency10.1VEGFA, NGF
42hyperandrogenism10.1POMC, IGF1
43hepatitis c virus10.1
44sudden infant death syndrome10.1
45morphine dependence10.1
46borderline personality disorder10.1
47heroin dependence10.1
48premature ejaculation10.1
49cerebritis10.1
50anxiety disorder10.1

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Symptoms for Opiate Dependence

About this section

Drugs & Therapeutics for Opiate Dependence

About this section

Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Genetic Tests for Opiate Dependence

About this section

Anatomical Context for Opiate Dependence

About this section

MalaCards organs/tissues related to Opiate Dependence:

31
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

About this section

MGI Mouse Phenotypes related to Opiate Dependence:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8IGF1, POMC, DRD3, OPRM1
2MP:00020068.8POMC, VEGFA, IGF1, TH
3MP:00053678.5IGF1, VEGFA, POMC, CCKBR, DRD3
4MP:00030128.3OPRM1, POMC, VEGFA, NGF, TH
5MP:00028737.9TH, IGF1, NGF, VEGFA, CREB1, OPRM1
6MP:00053797.8TH, IGF1, VEGFA, POMC, CCKBR, CREB1
7MP:00107717.7TH, IGF1, NGF, VEGFA, POMC, CCKBR
8MP:00053857.6TH, IGF1, NGF, VEGFA, POMC, CCKBR
9MP:00053847.6TH, IGF1, VEGFA, POMC, CREB1, OPRM1
10MP:00053867.5TH, NGF, VEGFA, POMC, CCKBR, CREB1
11MP:00107687.3TH, IGF1, NGF, VEGFA, POMC, CREB1
12MP:00036317.1OPRM1, TH, IGF1, NGF, VEGFA, POMC
13MP:00053787.1TH, IGF1, NGF, VEGFA, POMC, CCKBR
14MP:00053767.1TH, IGF1, NGF, VEGFA, POMC, CCKBR

Publications for Opiate Dependence

About this section

Articles related to Opiate Dependence:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. (24205275)
2013
2
Effects of opiate dependence through different administration routes on pulmonary inflammation and its severity. (24693370)
2013
3
Relative and age-dependent stimulation of soluble and cellular immunity in opiate dependence. (21918466)
2012
4
Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. (21920671)
2012
5
Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence. (19327850)
2011
6
The effect of pain on stroop performance in patients with opiate dependence in sustained remission. (21769047)
2011
7
Factors associated with the prescribing of buprenorphine or methadone for treatment of opiate dependence. (19004598)
2009
8
Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. (19608356)
2009
9
Economic evaluation of interventions to treat opiate dependence : a review of the evidence. (18429655)
2008
10
The neuropsychology of amphetamine and opiate dependence: implications for treatment. (17690986)
2007
11
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
12
Suicidal ideation in veterans receiving treatment for opiate dependence. (16903454)
2006
13
Profile of executive and memory function associated with amphetamine and opiate dependence. (16160707)
2006
14
Maternal deprivation specifically enhances vulnerability to opiate dependence. (17110797)
2006
15
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
16
Public policy statement on buprenorphine for opiate dependence and withdrawal. (15534969)
2004
17
Diamorphine treatment for opiate dependence: putative markers of concomitant heroin misuse. (11900600)
2001
18
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. (11122350)
2000
19
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (9702742)
1998
20
An open trial of naltrexone for opiate dependence. (16203482)
1998
21
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
22
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. (9315909)
1997
23
Decreased nociceptive sensitivity: a biological risk marker for opiate dependence? (9158227)
1997
24
Management of opiate dependence. (8745858)
1996
25
Use of morphine mixture to stabilize opiate dependence. (16203402)
1996
26
Opiate dependence, comorbidity and seasonality of birth. (8555277)
1995
27
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
28
A Markov model for NIDA data on treatment of opiate dependence. (1436013)
1992
29
Nasal administration of naloxone for detection of opiate dependence. (1560408)
1992
30
Analysis of clinical trials for treatment of opiate dependence: what are the possibilities? (1436010)
1992
31
Neurobiological mechanisms in cocaine and opiate dependence. (1311123)
1992
32
Statistical Issues in Clinical Trials for Treatment of Opiate Dependence. Technical review. Bethesda, Maryland, December 2-3, 1991. (1436009)
1992
33
New trends in infant pain management: potential for opiate dependence. (1876111)
1990
34
Discrimination of opiate dependence from opiate abstinence and methadone maintenance by use of the Derogatis scale. (3406052)
1988
35
The opiate dependence syndrome: replication study using the SODQ in a New York clinic. (3207935)
1988
36
Naltrexone in the treatment of opiate dependence. (3580701)
1987
37
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (2874232)
1986
38
The effect of tolerance on opiate dependence as measured by the adenylate cyclase rebound response to naloxone in the NG108-15 model system. (6099517)
1984
39
Physiological basis of opiate dependence. (6851851)
1983
40
Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence. (6126814)
1982
41
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
42
Recent trends in opiate dependence. (435878)
1979
43
Recent trends in opiate dependence. (455022)
1979
44
Agonist--antagonist properties of phenoxybenzamine in antinociception and opiate dependence tests. (572775)
1979
45
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
46
Naltrexone in the treatment of opiate dependence. (218108)
1978
47
Trends in methadone use in the treatment of opiate dependence in Canada. (872016)
1977
48
Prostaglandins, cyclic AMP and the mechanism of opiate dependence. (167256)
1975
49
Naloxone treatment of opiate dependence. A progress report. (5108223)
1971
50
Narcotic antagonists in opiate dependence. (4914724)
1970

Variations for Opiate Dependence

About this section

Expression for genes affiliated with Opiate Dependence

About this section
Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

About this section

Pathways related to Opiate Dependence according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CREB1, POMC
29.8CREB1, TH
39.7CREB1, NGF
4
Show member pathways
9.6VEGFA, POMC
5
Show member pathways
Signaling Pathways in Glioblastoma36
9.0IGF1, VEGFA, CREB1
69.0CREB1, VEGFA, IGF1
7
Show member pathways
9.0VEGFA, NGF, IGF1
89.0IGF1, NGF, VEGFA
9
Show member pathways
9.0TH, CREB1, DRD3, OPRM1
10
Show member pathways
8.9NPFF, CREB1, CCKBR
11
Show member pathways
8.9NGF, POMC, CREB1, OPRM1
128.9OPRM1, CREB1, NGF, TH
138.7TH, NGF, VEGFA, CREB1
148.6CREB1, VEGFA, NGF, IGF1
15
Show member pathways
8.2NPFF, OPRM1, DRD3, CCKBR, POMC
16
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.1IGF1, NGF, VEGFA, CREB1, OPRM1
17
Show member pathways
6.3NPFF, IGF1, NGF, VEGFA, POMC, CCKBR

Compounds for genes affiliated with Opiate Dependence

About this section

Compounds related to Opiate Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1gamma-butyrolactone439.9DRD3, TH
2quinpirole43 2810.8DRD3, CREB1, TH
3heroin43 49 1211.7POMC, OPRM1, DRD3
4yohimbine43 2 28 1212.6OPRM1, DRD3, CCKBR
5desipramine43 49 1211.5TH, NGF, CREB1
6methadone49 43 1211.5NGF, POMC, OPRM1
7naltrexone43 28 49 1212.5OPRM1, IGF1, POMC
8bromocriptine43 28 1211.5DRD3, CREB1, POMC, IGF1
9mptp439.5TH, DRD3, NGF
10naloxone43 28 49 1212.4POMC, OPRM1, CREB1
11valproate439.4IGF1, TH, CREB1
12amphetamine43 49 1211.4CCKBR, TH, OPRM1, POMC
13methamphetamine43 49 1211.4DRD3, OPRM1, TH, CREB1
14chelerythrine439.4IGF1, CREB1, OPRM1
15deltorphin i439.3OPRM1, NPFF
165-hydroxytryptamine439.3OPRM1, TH, POMC, CREB1
17acth439.2POMC, IGF1, CCKBR, CREB1
18gaba439.2TH, CREB1, OPRM1, POMC
19progestin439.1IGF1, TH, POMC, VEGFA
20octreotide43 59 28 1212.1IGF1, CCKBR, VEGFA, POMC
21clonidine43 49 28 1212.1POMC, OPRM1, IGF1
22nicotine43 28 49 1212.0CCKBR, OPRM1, NGF, TH, DRD3
236-hydroxydopamine439.0NGF, CREB1, TH, DRD3, OPRM1
24epinephrine43 24 1210.9TH, NGF, POMC, CREB1, OPRM1
25gf 109203x43 599.9VEGFA, NGF, OPRM1, CREB1
26histamine43 28 2410.9NGF, CCKBR, OPRM1, TH, CREB1
27haloperidol43 49 28 2 1212.8POMC, OPRM1, DRD3, TH, CREB1, CCKBR
28norepinephrine43 24 1210.7TH, CREB1, NGF, POMC, OPRM1, DRD3
29nmda43 289.7DRD3, CREB1, CCKBR, NGF, TH, OPRM1
30actinomycin d438.6CREB1, TH, IGF1, NGF, VEGFA
31sb 20358043 599.6VEGFA, CREB1, IGF1, CCKBR, NGF
32acetylcholine43 49 28 24 1212.6OPRM1, CREB1, POMC, NGF, TH, CCKBR
33adenylate438.6CREB1, CCKBR, POMC, NGF, TH, OPRM1
34glutamate438.6CREB1, OPRM1, DRD3, CCKBR, NGF, TH
35levodopa43 129.6DRD3, NGF, IGF1, TH, CREB1, OPRM1
36cycloheximide438.6POMC, VEGFA, NGF, IGF1, CREB1
37gnrh438.5NGF, POMC, TH, OPRM1, CREB1, IGF1
38tetrapeptide438.5OPRM1, CCKBR, NPFF
39testosterone43 59 24 1211.5CREB1, POMC, NGF, IGF1, TH, OPRM1
40cocaine43 129.4NGF, OPRM1, DRD3, CREB1, CCKBR, POMC
41vegf438.4IGF1, POMC, NGF, VEGFA, TH, CREB1
42opiate438.3CREB1, TH, POMC, NPFF, OPRM1, DRD3
43ly294002438.2TH, IGF1, NGF, CREB1, VEGFA, OPRM1
44glutamine438.2TH, IGF1, NGF, POMC, CCKBR, OPRM1
45cyclic amp43 249.1DRD3, TH, CREB1, NGF, NPFF, OPRM1
46morphine43 49 28 1211.1CREB1, CCKBR, NPFF, NGF, TH, OPRM1
47serine438.1POMC, DRD3, IGF1, NGF, OPRM1, CCKBR
48tyrosine437.9CREB1, TH, IGF1, CCKBR, NGF, DRD3
49dopamine43 28 24 1210.9IGF1, NGF, POMC, CCKBR, CREB1, DRD3
50dexamethasone43 49 28 1210.9NGF, TH, OPRM1, CREB1, POMC, VEGFA

GO Terms for genes affiliated with Opiate Dependence

About this section

Cellular components related to Opiate Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:00432049.3NPFF, TH
2platelet alpha granule lumenGO:00310939.1VEGFA, IGF1
3extracellular spaceGO:00056157.9NPFF, POMC, VEGFA, NGF, IGF1
4extracellular regionGO:00055767.8IGF1, NGF, VEGFA, POMC, NPFF

Biological processes related to Opiate Dependence according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:000196310.2DRD3, TH
2response to amphetamineGO:000197510.1DRD3, TH
3response to electrical stimulusGO:005160210.1NGF, TH
4Type I pneumocyte differentiationGO:006050910.0CREB1, IGF1
5adenylate cyclase-activating dopamine receptor signaling pathwayGO:000719110.0DRD3, OPRM1
6regulation of multicellular organism growthGO:004001410.0IGF1, DRD3
7social behaviorGO:003517610.0DRD3, TH
8positive regulation of mitosisGO:004584010.0DRD3, IGF1
9sensory perceptionGO:000760010.0CCKBR, OPRM1
10negative regulation of adenylate cyclase activityGO:000719410.0OPRM1, DRD3
11learningGO:00076129.9DRD3, TH
12eye photoreceptor cell developmentGO:00424629.8VEGFA, TH
13extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.8NGF, IGF1
14positive regulation of protein autophosphorylationGO:00319549.8NGF, VEGFA
15phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8OPRM1, CCKBR
16heart morphogenesisGO:00030079.7TH, VEGFA
17locomotory behaviorGO:00076269.7TH, DRD3, OPRM1
18response to morphineGO:00432789.7DRD3, NPFF
19response to peptide hormoneGO:00434349.6NGF, TH
20branching morphogenesis of an epithelial tubeGO:00487549.6VEGFA, IGF1
21phosphatidylinositol-mediated signalingGO:00480159.6CREB1, NGF, IGF1
22lactationGO:00075959.5VEGFA, CREB1
23sensory perception of painGO:00192339.5OPRM1, NGF
24memoryGO:00076139.4NGF, TH
25neuropeptide signaling pathwayGO:00072189.2NPFF, OPRM1, POMC
26positive regulation of cytosolic calcium ion concentrationGO:00072049.1CCKBR, OPRM1, NPFF
27positive regulation of cell proliferationGO:00082849.1DRD3, CCKBR, VEGFA, IGF1
28response to drugGO:00424939.0NGF, CREB1, DRD3, NPFF
29positive regulation of transcription from RNA polymerase II promoterGO:00459448.8DRD3, CREB1, POMC, VEGFA, IGF1

Molecular functions related to Opiate Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.9DRD3, TH
2G-protein coupled receptor bindingGO:00016649.4NPFF, POMC
3growth factor activityGO:00080838.9VEGFA, NGF, IGF1
4protein bindingGO:00055156.7TH, IGF1, VEGFA, KPNA3, CCKBR, CREB1

Products for genes affiliated with Opiate Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Opiate Dependence

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet