MCID: OPT003
MIFTS: 51

Opiate Dependence malady

Summaries for Opiate Dependence

About this section


Disease Ontology:10 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards based summary: Opiate Dependence, also known as opioid type dependence, is related to alcohol dependence and schizophrenia. An important gene associated with Opiate Dependence is DRD3 (dopamine receptor D3), and among its related pathways are Melanocyte Development and Pigmentation and p38 signaling mediated by MAPKAP kinases. The compounds gamma-butyrolactone and quinpirole have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Opiate Dependence

About this section

Opiate Dependence, Aliases & Descriptions:

Name: Opiate Dependence 10 12 62
Opioid Type Dependence 10 62
 
Opioid Dependence 62


External Ids:

Disease Ontology10 DOID:2559
MeSH35 D009293
ICD9CM29 304.0, 304.00

Related Diseases for Opiate Dependence

About this section

Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.4NGF, POMC, CCKBR, DRD3, OPRM1
2schizophrenia30.3TH, NGF, CCKBR, CREB1, DRD3, OPRM1
3hyperglycemia30.1IGF1, POMC, CREB1
4neuronitis10.3
5hepatitis10.3
6hepatitis c10.3
7blindness10.3
8hepatitis c virus10.1
9sudden infant death syndrome10.1
10morphine dependence10.1
11borderline personality disorder10.1
12heroin dependence10.1
13premature ejaculation10.1
14cerebritis10.1
15anxiety disorder10.1
16personality disorder10.1
17pertussis10.1
18endotheliitis10.1
19opioid abuse10.1NPFF
20cerebral hypoxia10.1CREB1
21diabetic autonomic neuropathy10.0NGF
22macular degeneration, age-related, 110.0VEGFA
23hyperaldosteronism10.0TH, POMC
24movement disease10.0TH, DRD3
25bipolar disorder10.0TH, CREB1
26panic disorder10.0POMC, CCKBR
27craniopharyngioma10.0IGF1, POMC
28sheehan syndrome10.0POMC, IGF1
29addison's disease10.0POMC, TH
30gonadal disease10.0IGF1, POMC
31leydig cell tumor10.0CREB1, POMC
32hypothryoidism, congenital, nongoitrous 410.0POMC, IGF1
33pituitary gland disease10.0POMC, IGF1
34rett syndrome10.0TH, NGF
35pituitary hormone deficiency, combined, 210.0IGF1, POMC
36amenorrhea10.0POMC, IGF1
37growth hormone deficiency10.0IGF1, POMC
38precocious puberty10.0IGF1, POMC
39hypopituitarism10.0IGF1, POMC
40withdrawal disorder10.0NPFF, OPRM1
41opioid dependence10.0OPRM1, DRD3
42adrenocortical carcinoma10.0CREB1, POMC
43substance dependence10.0DRD3, OPRM1
44drug dependence10.0DRD3, OPRM1
45medullary thyroid carcinoma, familial10.0POMC, CCKBR, CREB1
46exudative vitreoretinopathy 110.0IGF1, VEGFA
47ganglioneuroma10.0TH, NGF, POMC
48parkinson disease, late-onset10.0DRD3, NGF, TH
49substance abuse10.0DRD3, OPRM1
50adrenal cortical adenoma10.0CREB1, POMC

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Symptoms for Opiate Dependence

About this section

Drugs & Therapeutics for Opiate Dependence

About this section

Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Genetic Tests for Opiate Dependence

About this section

Anatomical Context for Opiate Dependence

About this section

MalaCards organs/tissues related to Opiate Dependence:

33
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

About this section

MGI Mouse Phenotypes related to Opiate Dependence:

37 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8IGF1, POMC, DRD3, OPRM1
2MP:00020068.8POMC, VEGFA, IGF1, TH
3MP:00053678.5IGF1, VEGFA, POMC, CCKBR, DRD3
4MP:00030128.3OPRM1, POMC, VEGFA, NGF, TH
5MP:00028737.9TH, IGF1, NGF, VEGFA, CREB1, OPRM1
6MP:00053797.8TH, IGF1, VEGFA, POMC, CCKBR, CREB1
7MP:00107717.7TH, IGF1, NGF, VEGFA, POMC, CCKBR
8MP:00053857.6TH, IGF1, NGF, VEGFA, POMC, CCKBR
9MP:00053847.6TH, IGF1, VEGFA, POMC, CREB1, OPRM1
10MP:00053867.5TH, NGF, VEGFA, POMC, CCKBR, CREB1
11MP:00107687.3TH, IGF1, NGF, VEGFA, POMC, CREB1
12MP:00036317.1OPRM1, TH, IGF1, NGF, VEGFA, POMC
13MP:00053787.1TH, IGF1, NGF, VEGFA, POMC, CCKBR
14MP:00053767.1TH, IGF1, NGF, VEGFA, POMC, CCKBR

Publications for Opiate Dependence

About this section

Articles related to Opiate Dependence:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. (24205275)
2013
2
Effects of opiate dependence through different administration routes on pulmonary inflammation and its severity. (24693370)
2013
3
Relative and age-dependent stimulation of soluble and cellular immunity in opiate dependence. (21918466)
2012
4
Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. (21920671)
2012
5
Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence. (19327850)
2011
6
The effect of pain on stroop performance in patients with opiate dependence in sustained remission. (21769047)
2011
7
Factors associated with the prescribing of buprenorphine or methadone for treatment of opiate dependence. (19004598)
2009
8
Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. (19608356)
2009
9
Economic evaluation of interventions to treat opiate dependence : a review of the evidence. (18429655)
2008
10
The neuropsychology of amphetamine and opiate dependence: implications for treatment. (17690986)
2007
11
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
12
Suicidal ideation in veterans receiving treatment for opiate dependence. (16903454)
2006
13
Profile of executive and memory function associated with amphetamine and opiate dependence. (16160707)
2006
14
Maternal deprivation specifically enhances vulnerability to opiate dependence. (17110797)
2006
15
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
16
Public policy statement on buprenorphine for opiate dependence and withdrawal. (15534969)
2004
17
Diamorphine treatment for opiate dependence: putative markers of concomitant heroin misuse. (11900600)
2001
18
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. (11122350)
2000
19
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (9702742)
1998
20
An open trial of naltrexone for opiate dependence. (16203482)
1998
21
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
22
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. (9315909)
1997
23
Decreased nociceptive sensitivity: a biological risk marker for opiate dependence? (9158227)
1997
24
Management of opiate dependence. (8745858)
1996
25
Use of morphine mixture to stabilize opiate dependence. (16203402)
1996
26
Opiate dependence, comorbidity and seasonality of birth. (8555277)
1995
27
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
28
A Markov model for NIDA data on treatment of opiate dependence. (1436013)
1992
29
Nasal administration of naloxone for detection of opiate dependence. (1560408)
1992
30
Analysis of clinical trials for treatment of opiate dependence: what are the possibilities? (1436010)
1992
31
Neurobiological mechanisms in cocaine and opiate dependence. (1311123)
1992
32
Statistical Issues in Clinical Trials for Treatment of Opiate Dependence. Technical review. Bethesda, Maryland, December 2-3, 1991. (1436009)
1992
33
New trends in infant pain management: potential for opiate dependence. (1876111)
1990
34
Discrimination of opiate dependence from opiate abstinence and methadone maintenance by use of the Derogatis scale. (3406052)
1988
35
The opiate dependence syndrome: replication study using the SODQ in a New York clinic. (3207935)
1988
36
Naltrexone in the treatment of opiate dependence. (3580701)
1987
37
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (2874232)
1986
38
The effect of tolerance on opiate dependence as measured by the adenylate cyclase rebound response to naloxone in the NG108-15 model system. (6099517)
1984
39
Physiological basis of opiate dependence. (6851851)
1983
40
Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence. (6126814)
1982
41
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
42
Recent trends in opiate dependence. (435878)
1979
43
Recent trends in opiate dependence. (455022)
1979
44
Agonist--antagonist properties of phenoxybenzamine in antinociception and opiate dependence tests. (572775)
1979
45
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
46
Naltrexone in the treatment of opiate dependence. (218108)
1978
47
Trends in methadone use in the treatment of opiate dependence in Canada. (872016)
1977
48
Prostaglandins, cyclic AMP and the mechanism of opiate dependence. (167256)
1975
49
Naloxone treatment of opiate dependence. A progress report. (5108223)
1971
50
Narcotic antagonists in opiate dependence. (4914724)
1970

Variations for Opiate Dependence

About this section

Expression for genes affiliated with Opiate Dependence

About this section

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

About this section

Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CREB1, POMC
29.8CREB1, TH
39.7CREB1, NGF
4
Show member pathways
9.6VEGFA, POMC
5
Show member pathways
Signaling Pathways in Glioblastoma38
9.0IGF1, VEGFA, CREB1
69.0CREB1, VEGFA, IGF1
7
Show member pathways
9.0VEGFA, NGF, IGF1
89.0IGF1, NGF, VEGFA
9
Show member pathways
9.0TH, CREB1, DRD3, OPRM1
10
Show member pathways
8.9NPFF, CREB1, CCKBR
11
Show member pathways
8.9NGF, POMC, CREB1, OPRM1
128.9OPRM1, CREB1, NGF, TH
13
Show member pathways
Peptide GPCRs38
8.8NPFF, OPRM1, CCKBR
148.7TH, NGF, VEGFA, CREB1
158.6CREB1, VEGFA, NGF, IGF1
16
Show member pathways
8.2NPFF, OPRM1, DRD3, CCKBR, POMC
17
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.1IGF1, NGF, VEGFA, CREB1, OPRM1
18
Show member pathways
6.3NPFF, IGF1, NGF, VEGFA, POMC, CCKBR

Compounds for genes affiliated with Opiate Dependence

About this section

Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1gamma-butyrolactone459.9DRD3, TH
2quinpirole45 3010.8DRD3, CREB1, TH
3heroin45 51 1311.7POMC, OPRM1, DRD3
4yohimbine45 3 30 1312.6OPRM1, DRD3, CCKBR
5desipramine45 51 1311.5TH, NGF, CREB1
6methadone51 45 1311.5NGF, POMC, OPRM1
7naltrexone45 30 51 1312.5OPRM1, IGF1, POMC
8bromocriptine45 30 1311.5DRD3, CREB1, POMC, IGF1
9mptp459.5TH, DRD3, NGF
10naloxone45 30 51 1312.4POMC, OPRM1, CREB1
11valproate459.4IGF1, TH, CREB1
12amphetamine45 51 1311.4CCKBR, TH, OPRM1, POMC
13methamphetamine45 51 1311.4DRD3, OPRM1, TH, CREB1
14chelerythrine459.4IGF1, CREB1, OPRM1
15deltorphin i459.3OPRM1, NPFF
165-hydroxytryptamine459.3OPRM1, TH, POMC, CREB1
17acth459.2POMC, IGF1, CCKBR, CREB1
18gaba459.2TH, CREB1, OPRM1, POMC
19progestin459.1IGF1, TH, POMC, VEGFA
20octreotide45 61 30 1312.1IGF1, CCKBR, VEGFA, POMC
21clonidine45 51 30 1312.1POMC, OPRM1, IGF1
22nicotine45 30 51 1312.0CCKBR, OPRM1, NGF, TH, DRD3
236-hydroxydopamine459.0NGF, CREB1, TH, DRD3, OPRM1
24epinephrine45 26 1310.9TH, NGF, POMC, CREB1, OPRM1
25gf 109203x45 619.9VEGFA, NGF, OPRM1, CREB1
26histamine45 30 2610.9NGF, CCKBR, OPRM1, TH, CREB1
27haloperidol45 51 30 3 1312.8POMC, OPRM1, DRD3, TH, CREB1, CCKBR
28norepinephrine45 26 1310.7TH, CREB1, NGF, POMC, OPRM1, DRD3
29nmda45 309.7DRD3, CREB1, CCKBR, NGF, TH, OPRM1
30actinomycin d458.6CREB1, TH, IGF1, NGF, VEGFA
31sb 20358045 619.6VEGFA, CREB1, IGF1, CCKBR, NGF
32acetylcholine45 51 30 26 1312.6OPRM1, CREB1, POMC, NGF, TH, CCKBR
33adenylate458.6CREB1, CCKBR, POMC, NGF, TH, OPRM1
34glutamate458.6CREB1, OPRM1, DRD3, CCKBR, NGF, TH
35levodopa45 139.6DRD3, NGF, IGF1, TH, CREB1, OPRM1
36cycloheximide458.6POMC, VEGFA, NGF, IGF1, CREB1
37gnrh458.5NGF, POMC, TH, OPRM1, CREB1, IGF1
38tetrapeptide458.5OPRM1, CCKBR, NPFF
39testosterone45 61 26 1311.5CREB1, POMC, NGF, IGF1, TH, OPRM1
40cocaine45 139.4NGF, OPRM1, DRD3, CREB1, CCKBR, POMC
41vegf458.4IGF1, POMC, NGF, VEGFA, TH, CREB1
42opiate458.3CREB1, TH, POMC, NPFF, OPRM1, DRD3
43ly294002458.2TH, IGF1, NGF, CREB1, VEGFA, OPRM1
44glutamine458.2TH, IGF1, NGF, POMC, CCKBR, OPRM1
45cyclic amp45 269.1DRD3, TH, CREB1, NGF, NPFF, OPRM1
46morphine45 51 30 1311.1CREB1, CCKBR, NPFF, NGF, TH, OPRM1
47serine458.1POMC, DRD3, IGF1, NGF, OPRM1, CCKBR
48tyrosine457.9CREB1, TH, IGF1, CCKBR, NGF, DRD3
49dopamine45 30 26 1310.9IGF1, NGF, POMC, CCKBR, CREB1, DRD3
50dexamethasone45 51 30 1310.9NGF, TH, OPRM1, CREB1, POMC, VEGFA

GO Terms for genes affiliated with Opiate Dependence

About this section

Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:00432049.3NPFF, TH
2platelet alpha granule lumenGO:00310939.1VEGFA, IGF1
3extracellular spaceGO:00056157.9VEGFA, IGF1, NGF, POMC, NPFF
4extracellular regionGO:00055767.8NPFF, IGF1, NGF, VEGFA, POMC

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:000196310.2DRD3, TH
2response to amphetamineGO:000197510.1DRD3, TH
3response to electrical stimulusGO:005160210.1NGF, TH
4Type I pneumocyte differentiationGO:006050910.0CREB1, IGF1
5adenylate cyclase-activating dopamine receptor signaling pathwayGO:000719110.0DRD3, OPRM1
6regulation of multicellular organism growthGO:004001410.0IGF1, DRD3
7social behaviorGO:003517610.0DRD3, TH
8positive regulation of mitosisGO:004584010.0DRD3, IGF1
9sensory perceptionGO:000760010.0CCKBR, OPRM1
10negative regulation of adenylate cyclase activityGO:000719410.0OPRM1, DRD3
11learningGO:00076129.9DRD3, TH
12eye photoreceptor cell developmentGO:00424629.8VEGFA, TH
13extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.8NGF, IGF1
14positive regulation of protein autophosphorylationGO:00319549.8NGF, VEGFA
15phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8OPRM1, CCKBR
16heart morphogenesisGO:00030079.7TH, VEGFA
17locomotory behaviorGO:00076269.7TH, DRD3, OPRM1
18response to morphineGO:00432789.7DRD3, NPFF
19response to peptide hormoneGO:00434349.6NGF, TH
20branching morphogenesis of an epithelial tubeGO:00487549.6VEGFA, IGF1
21phosphatidylinositol-mediated signalingGO:00480159.6CREB1, NGF, IGF1
22lactationGO:00075959.5VEGFA, CREB1
23sensory perception of painGO:00192339.5OPRM1, NGF
24memoryGO:00076139.4NGF, TH
25neuropeptide signaling pathwayGO:00072189.2NPFF, OPRM1, POMC
26positive regulation of cytosolic calcium ion concentrationGO:00072049.1CCKBR, OPRM1, NPFF
27positive regulation of cell proliferationGO:00082849.1DRD3, CCKBR, VEGFA, IGF1
28response to drugGO:00424939.0NGF, CREB1, DRD3, NPFF
29positive regulation of transcription from RNA polymerase II promoterGO:00459448.8DRD3, CREB1, POMC, VEGFA, IGF1

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.9TH, DRD3
2G-protein coupled receptor bindingGO:00016649.4POMC, NPFF
3growth factor activityGO:00080838.9IGF1, NGF, VEGFA
4protein bindingGO:00055156.7TH, IGF1, VEGFA, KPNA3, CCKBR, CREB1

Products for genes affiliated with Opiate Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Opiate Dependence

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet