MCID: OPT003
MIFTS: 56

Opiate Dependence malady

Summaries for Opiate Dependence

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards: Opiate Dependence, also known as opioid dependence, is related to alcohol dependence and heroin dependence. An important gene associated with Opiate Dependence is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Dopamine receptors and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds carbachol and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:63 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Description from OMIM:46 610064

Aliases & Classifications for Opiate Dependence

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8Disease Ontology, 10DISEASES, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

opiate dependence 8 10
opioid dependence 46 44
opioid type dependence 8


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Disease Ontology8 DOID:2559
ICD9CM27 304.0, 304.00
MeSH34 D009293

Related Diseases for Opiate Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.7DRD2, OPRM1
2heroin dependence30.7DRD2
3drug dependence30.6DRD2, DRD3, OPRM1
4cocaine dependence30.5DRD2, DRD3, OPRM1, POMC
5substance dependence30.4OPRM1, DRD3, DRD2, COMT
6opioid abuse30.3NPFF
7conduct disorder30.3DRD2, COMT
8attention deficit hyperactivity disorder30.3DRD2, BDNF, COMT
9hepatitis30.3COMT
10substance abuse30.2DRD2, DRD3, OPRM1
11sudden infant death syndrome30.0TH
12personality disorder30.0DRD2, DRD3
13schizophrenia30.0COMT, DRD3
14anxiety disorder30.0BDNF
15hyperglycemia30.0BDNF, CREB1, IGF1, POMC
16nicotine dependence30.0DRD2
17cocaine abuse30.0DRD2
18leukemia30.0CCKBR, CREB1, NGF, ADCY10
19panic disorder30.0CCKBR, POMC
20morphine dependence10.5
21neuronitis10.3
22cannabis dependence10.2
23hepatitis c10.2
24neonatal abstinence syndrome10.2
25opioid dependence 110.2
26cerebritis10.0
27dependent personality disorder10.0
28borderline personality disorder10.0
29premature ejaculation10.0
30pertussis10.0
31alcoholic hepatitis10.0
32hepatitis a10.0
33tuberculosis10.0
34viral hepatitis10.0
35restless legs syndrome10.0DRD2
36delusional disorder10.0DRD2
37fibromyalgia10.0COMT
38myocardial infarction10.0COMT
39myoclonus-dystonia10.0DRD2
40thyroid cancer10.0CCKBR
41atopic dermatitis10.0NGF
42paranoid schizophrenia10.0COMT
43gastrinoma10.0CCKBR
44leiomyoma10.0COMT
45dysautonomia10.0SNCA
46hyperparathyroidism10.0ADCY10
47neuropathy10.0NGF
48encephalomyelitis10.0NGF
49blindness10.0VEGFA
50pure autonomic failure10.0SNCA

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Clinical Features for Opiate Dependence

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46OMIM
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Clinical features from OMIM:

610064

Drugs & Therapeutics for Opiate Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opiate Dependence

Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Search CenterWatch for Opiate Dependence

Genetic Tests for Opiate Dependence

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Anatomical Context for Opiate Dependence

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32MalaCards
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MalaCards organs/tissues related to Opiate Dependence:

32
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

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36MGI
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Publications for Opiate Dependence

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50PubMed
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Articles related to Opiate Dependence:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Duration of opiate exposure as a determinant of arterial stiffness and vascular age in male opiate dependence: a longitudinal study. (24329809)
2013
2
KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. (22960338)
2012
3
Pharmacological treatments of opiate dependence. (21524267)
2011
4
Alcohol-related brief intervention in patients treated for opiate or cocaine dependence: a randomized controlled study. (21849027)
2011
5
Differences between men and women in the course of opiate dependence: is there a telescoping effect? (19838765)
2010
6
Lapse and relapse following inpatient treatment of opiate dependence. (20669601)
2010
7
Factors associated with the prescribing of buprenorphine or methadone for treatment of opiate dependence. (19004598)
2009
8
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
9
Dihydrocodeine as effective as methadone for maintenance of treatment for opiate dependence? (17652570)
2007
10
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
11
What are America's opportunities for harm reduction strategies in opiate dependence? (16188710)
2005
12
Buprenorphine in the treatment of opiate dependence: its pharmacology and social context of use in the U.S. (15279124)
2004
13
Safety and health policy considerations related to the use of buprenorphine/naloxone as an office-based treatment for opiate dependence. (12738352)
2003
14
Behavioral naltrexone therapy: an integrated treatment for opiate dependence. (12495797)
2002
15
Salivary cortisol during opiate dependence and withdrawal. (11341855)
2001
16
Concurrent substance use and outcome in combined behavioral and naltrexone therapy for opiate dependence. (11506261)
2001
17
Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats. (10943688)
2000
18
An open trial of naltrexone for opiate dependence. (16203482)
1998
19
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
20
Relevance of deficient CYP2D6 in opiate dependence. (9918141)
1998
21
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. (9315909)
1997
22
Assessing the helping alliance and its impact in the treatment of opiate dependence. (9330921)
1997
23
Management of opiate dependence. (8745858)
1996
24
Management of opiate dependence. (8745871)
1995
25
Methadone maintenance treatment in opiate dependence: a review. (7950725)
1994
26
Nasal administration of naloxone for detection of opiate dependence. (1560408)
1992
27
Intraspinal release of substance P and calcitonin gene-related peptide during opiate dependence and withdrawal. (1717887)
1991
28
New trends in infant pain management: potential for opiate dependence. (1876111)
1990
29
FMRF-NH2-like mammalian octapeptide: possible role in opiate dependence and abstinence. (2284204)
1990
30
Pertussis toxin inhibits morphine analgesia and prevents opiate dependence. (2315351)
1990
31
Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. (2682399)
1989
32
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria. (2763981)
1989
33
Use predicts treatment outcome, not opiate dependence or withdrawal. (2641030)
1989
34
Quantitative experimental analysis of the emergence of opiate dependence. (2780577)
1989
35
A theory on the nature of physiologic opiate dependence: a formal statement. (3018569)
1986
36
Methadone treatment of opiate dependence in Canada. (3864480)
1985
37
Treatment of behavioral and psychiatric problems associated with opiate dependence. (6427622)
1984
38
Assessment and extinction of conditioned withdrawal-like responses in an integrated treatment for opiate dependence. (6443380)
1984
39
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
40
Naltrexone: a short-term treatment for opiate dependence. (7340503)
1981
41
The naloxone test for opiate dependence. (7357808)
1980
42
Recent trends in opiate dependence. (455022)
1979
43
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
44
A seven year study of opiate dependence in Malaysia. (683053)
1978
45
Trends in methadone use in the treatment of opiate dependence in Canada. (872016)
1977
46
Neuronal aspects of opiate dependence and tolerance in comparison to central depressants. (22993)
1977
47
Criminality as a prognostic factor in opiate dependence. (1139087)
1975
48
Levomethadyl in maintenance treatment of opiate dependence. (5067346)
1972
49
Alcohol dependence and opiate dependence: lack of relationship in mice. (5102945)
1971
50
Opiate dependence and the use of narcotics for the relief of pain. (5728219)
1968

Genetic Variations for Opiate Dependence

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Expression for genes affiliated with Opiate Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opiate Dependence

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DRD2, DRD3
2
Hide members
9.8DRD2, DRD3, TH
3
Hide members
9.2BDNF, DRD2, CREB1, TH
49.2BDNF, DRD2, CREB1, TH
59.1NGF, IGF1, VEGFA
6
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9.0OPRM1, CREB1, POMC, NGF
79.0TH, NGF, SNCA, CREB1, OPRM1
8
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8.9NGF, VEGFA, CREB1, BDNF
98.7BDNF, CREB1, VEGFA, NGF, TH
108.6IGF1, VEGFA, CREB1, BDNF
11
Hide members
8.5ADCY10, COMT, DRD2, DRD3, OPRM1, CREB1
12
Hide members
8.1CCKBR, NPFF, DRD2, DRD3, OPRM1, POMC
13
Hide members
6.5CCKBR, NPFF, DRD2, DRD3, OPRM1, CREB1

Compounds for genes affiliated with Opiate Dependence

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1carbachol44 28 1112.1SNCA, ADCY10
2cycloheximide449.8ADCY10
3gnrh449.8TH, CREB1, BDNF
42,3-dideoxyadenosine449.6ADCY10, CREB1, TH
5apomorphine44 28 1111.6TH, SNCA, DRD2, DRD3, COMT
6quinpirole44 2810.5ADCY10, TH, CREB1, DRD3, DRD2
7dopac449.5COMT, BDNF, DRD3, TH
8atropine44 28 1111.5CREB1, ADCY10, NGF, SNCA
9octreotide44 59 28 1112.4ADCY10, CCKBR, DRD2, IGF1
10yohimbine44 28 2 1112.4CCKBR, DRD3, OPRM1, ADCY10, DRD2
11pramipexole44 49 28 1112.4DRD3, DRD2, BDNF, COMT, TH
12cabergoline28 44 1111.3COMT, DRD2, DRD3, IGF1
13heroin44 49 1111.3OPRM1, DRD3, POMC, DRD2, COMT
14amphetamine44 1110.3CCKBR, DRD2, SNCA, POMC, TH
15bromocriptine28 44 1111.3DRD3, CREB1, ADCY10, POMC, COMT
16ly294002449.3OPRM1, CREB1, VEGFA, NGF
17glutamate449.3DRD2, DRD3, CCKBR, SNCA, OPRM1, COMT
18risperidone28 44 49 59 11 2414.2COMT, CREB1, BDNF, DRD3, DRD2
19selegiline44 1110.2BDNF, TH, NGF, COMT, SNCA
20maoa449.2COMT, BDNF, TH, DRD2, POMC
21quetiapine44 49 28 11 2413.2DRD3, TH, BDNF, DRD2
22chelerythrine448.9OPRM1, CREB1, IGF1, ADCY10
23methadone44 49 1110.9DRD2, POMC, NGF, OPRM1, BDNF
24nicotine44 49 28 1111.9TH, NGF, OPRM1, DRD2, CCKBR, COMT
25nmda44 289.9COMT, CCKBR, OPRM1, NGF, TH, BDNF
26clozapine44 28 49 1111.9POMC, TH, COMT, BDNF, DRD2, DRD3
27catecholamine448.8COMT, BDNF, DRD3, SNCA, POMC, TH
28mptp448.8COMT, TH, BDNF, DRD2, DRD3, SNCA
29gf 109203x44 599.7ADCY10, VEGFA, NGF, OPRM1, CREB1
305-hydroxytryptamine448.7COMT, DRD2, OPRM1, CREB1, POMC, TH
31dexamethasone44 49 28 1111.5ADCY10, CREB1, VEGFA, POMC, OPRM1, TH
32methamphetamine44 49 1110.5COMT, BDNF, DRD2, DRD3, OPRM1, CREB1
33gaba448.5BDNF, CREB1, ME2, POMC, TH, OPRM1
34histamine44 28 2410.4CCKBR, CREB1, BDNF, OPRM1, NGF, TH
35sb 20358044 599.4SNCA, CCKBR, CREB1, IGF1, NGF, VEGFA
36haloperidol44 28 2 49 1112.3BDNF, CCKBR, TH, DRD2, CREB1, DRD3
376-hydroxydopamine448.2CREB1, TH, NGF, SNCA, OPRM1, DRD3
38norepinephrine44 11 2410.0OPRM1, DRD3, DRD2, BDNF, CREB1, SNCA
39glutamine447.9CCKBR, OPRM1, CREB1, SNCA, IGF1, POMC
40opiate447.9TH, ADCY10, POMC, OPRM1, DRD3, DRD2
41epinephrine44 11 249.8ADCY10, CREB1, OPRM1, DRD2, BDNF, COMT
42morphine44 49 28 1110.8COMT, CCKBR, NPFF, DRD2, OPRM1, CREB1
43cyclic amp44 248.6TH, ADCY10, OPRM1, BDNF, CREB1, NPFF
44dopamine44 28 11 2410.6DRD2, BDNF, TH, IGF1, SNCA, OPRM1
45acetylcholine44 49 28 11 2411.6POMC, NGF, CREB1, ADCY10, OPRM1, SNCA
46adenylate447.6ADCY10, TH, NGF, POMC, SNCA, CREB1
47levodopa44 118.5COMT, BDNF, DRD2, DRD3, TH, IGF1
48vegf447.5BDNF, DRD2, CREB1, VEGFA, IGF1, POMC
49cocaine44 118.4TH, NGF, POMC, SNCA, CREB1, OPRM1
50testosterone44 59 11 2410.4SNCA, TH, POMC, IGF1, CREB1, OPRM1

GO Terms for genes affiliated with Opiate Dependence

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16Gene Ontology
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Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.2TH, DRD2, NPFF
2synaptic vesicleGO:0080219.1BDNF, SNCA, TH
3dendriteGO:0304258.7ADCY10, TH, DRD2, NPFF
4extracellular regionGO:0055767.0NGF, POMC, IGF1, VEGFA, SNCA, NPFF

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD2, DRD3
2response to histamineGO:03477610.4DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.4DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.4DRD2, DRD3
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.4DRD2, DRD3
6negative regulation of dopamine metabolic processGO:04596310.3SNCA, COMT
7dopamine metabolic processGO:04241710.3DRD2, DRD3
8regulation of locomotionGO:04001210.3SNCA, DRD3
9negative regulation of protein secretionGO:05070910.3DRD2, DRD3
10G-protein coupled receptor internalizationGO:00203110.2DRD2, DRD3
11dopamine biosynthetic processGO:04241610.2TH, SNCA
12response to light stimulusGO:00941610.2TH, DRD2
13synaptic transmission, dopaminergicGO:00196310.2DRD2, DRD3, TH
14reduction of cytosolic calcium ion concentrationGO:05148110.2OPRM1, DRD2
15response to amphetamineGO:00197510.2DRD2, DRD3, TH
16behavioral response to ethanolGO:04814910.2DRD2, OPRM1
17regulation of dopamine secretionGO:01405910.2SNCA, DRD3, DRD2
18behavioral response to cocaineGO:04814810.2DRD2, DRD3, SNCA
19adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.1DRD3, OPRM1
20learningGO:00761210.1TH, DRD3, COMT
21sensory perceptionGO:00760010.1CCKBR, OPRM1
22prepulse inhibitionGO:06013410.1DRD3, DRD2
23negative regulation of adenylate cyclase activityGO:00719410.1OPRM1, DRD3, DRD2
24arachidonic acid secretionGO:05048210.0DRD2, DRD3
25neurotransmitter biosynthetic processGO:04213610.0TH, COMT
26positive regulation of renal sodium excretionGO:0358159.9DRD2, DRD3
27Type I pneumocyte differentiationGO:0605099.9CREB1, IGF1
28positive regulation of protein autophosphorylationGO:0319549.9NGF, VEGFA
29feeding behaviorGO:0076319.9BDNF, CCKBR, DRD2
30locomotory behaviorGO:0076269.8TH, OPRM1, DRD3, DRD2
31response to lipopolysaccharideGO:0324969.8TH, NGF, SNCA, COMT
32circadian regulation of gene expressionGO:0329229.7DRD2, DRD3
33response to morphineGO:0432789.6NPFF, DRD2, DRD3
34negative regulation of neuron apoptotic processGO:0435249.5BDNF, SNCA, NGF
35response to hypoxiaGO:0016669.4BDNF, DRD2, VEGFA, TH
36regulation of excitatory postsynaptic membrane potentialGO:0600799.2BDNF, NPFF, SNCA
37elevation of cytosolic calcium ion concentrationGO:0072049.1OPRM1, NPFF, CCKBR
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.6DRD2, DRD3, CREB1, VEGFA, IGF1, POMC
39response to drugGO:0424938.5NGF, COMT, NPFF, DRD2, DRD3, CREB1

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.0TH, SNCA
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD3, DRD2
3dopamine bindingGO:0352409.8TH, DRD3, DRD2
4growth factor activityGO:0080838.3BDNF, VEGFA, IGF1, NGF

Products for genes affiliated with Opiate Dependence

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Sources for Opiate Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet