MCID: OPT003
MIFTS: 56

Opiate Dependence malady

Summaries for Opiate Dependence

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards: Opiate Dependence, also known as opioid dependence, is related to alcohol dependence and heroin dependence. An important gene associated with Opiate Dependence is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Dopamine receptors and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds carbachol and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:63 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Description from OMIM:46 610064

Aliases & Classifications for Opiate Dependence

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8Disease Ontology, 10DISEASES, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

opiate dependence 8 10
opioid dependence 46 44
opioid type dependence 8


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Disease Ontology8 DOID:2559
ICD9CM27 304.0, 304.00
MeSH34 D009293

Related Diseases for Opiate Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.7DRD2, OPRM1
2heroin dependence30.7DRD2
3drug dependence30.6DRD2, DRD3, OPRM1
4cocaine dependence30.5DRD2, DRD3, OPRM1, POMC
5substance dependence30.4OPRM1, DRD3, DRD2, COMT
6opioid abuse30.3NPFF
7conduct disorder30.3DRD2, COMT
8attention deficit hyperactivity disorder30.3DRD2, BDNF, COMT
9hepatitis30.3COMT
10substance abuse30.2DRD2, DRD3, OPRM1
11sudden infant death syndrome30.0TH
12personality disorder30.0DRD2, DRD3
13schizophrenia30.0COMT, DRD3
14anxiety disorder30.0BDNF
15hyperglycemia30.0BDNF, CREB1, IGF1, POMC
16nicotine dependence30.0DRD2
17cocaine abuse30.0DRD2
18leukemia30.0CCKBR, CREB1, NGF, ADCY10
19panic disorder30.0CCKBR, POMC
20morphine dependence10.5
21neuronitis10.3
22cannabis dependence10.2
23hepatitis c10.2
24neonatal abstinence syndrome10.2
25opioid dependence 110.2
26cerebritis10.0
27dependent personality disorder10.0
28borderline personality disorder10.0
29premature ejaculation10.0
30pertussis10.0
31alcoholic hepatitis10.0
32hepatitis a10.0
33tuberculosis10.0
34viral hepatitis10.0
35restless legs syndrome10.0DRD2
36delusional disorder10.0DRD2
37fibromyalgia10.0COMT
38myocardial infarction10.0COMT
39myoclonus-dystonia10.0DRD2
40thyroid cancer10.0CCKBR
41atopic dermatitis10.0NGF
42paranoid schizophrenia10.0COMT
43gastrinoma10.0CCKBR
44leiomyoma10.0COMT
45dysautonomia10.0SNCA
46hyperparathyroidism10.0ADCY10
47neuropathy10.0NGF
48encephalomyelitis10.0NGF
49blindness10.0VEGFA
50pure autonomic failure10.0SNCA

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Clinical Features for Opiate Dependence

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46OMIM
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Clinical features from OMIM:

610064

Drugs & Therapeutics for Opiate Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opiate Dependence

Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Search CenterWatch for Opiate Dependence

Genetic Tests for Opiate Dependence

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Anatomical Context for Opiate Dependence

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32MalaCards
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MalaCards organs/tissues related to Opiate Dependence:

32
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

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36MGI
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Publications for Opiate Dependence

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50PubMed
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Articles related to Opiate Dependence:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. (24205275)
2013
2
Manifold implications of forgotten hyperglycemia in clinical opiate dependence. (22313373)
2013
3
Alpha-synuclein and heroin craving in opiate-dependent patients on injectable heroin maintenance. (21309955)
2012
4
Ecological momentary assessment in alcohol, tobacco, cannabis and opiate dependence: a comparison of feasibility and validity. (22647899)
2012
5
Association of nerve growth factor and vascular endothelial growth factor A with psychometric measurements of opiate dependence: results of a pilot study in patients participating in a structured diamorphine maintenance program. (22517242)
2012
6
Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence. (19327850)
2011
7
The effect of pain on stroop performance in patients with opiate dependence in sustained remission. (21769047)
2011
8
Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. (20728009)
2010
9
How to find non-dependent opiate users: a comparison of sampling methods in a field study of opium and heroin users. (19747812)
2010
10
An investigation of cigarette smoking behavior and nicotine dependence among Chinese opiate addicts. (19559539)
2009
11
Economic evaluation of interventions to treat opiate dependence : a review of the evidence. (18429655)
2008
12
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. (18355989)
2008
13
Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males. (18077142)
2008
14
Profile of executive and memory function associated with amphetamine and opiate dependence. (16160707)
2006
15
A telemetric examination of cardiovascular function during the development of, and recovery from, opiate dependence in rats. (16624345)
2006
16
The effectiveness of community maintenance with methadone or buprenorphine for treating opiate dependence. (15720937)
2005
17
Treatment of depression in patients with opiate dependence. (15556125)
2004
18
White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. (15313520)
2004
19
Craving by imagery cue reactivity in opiate dependence following detoxification. (21206851)
2003
20
A pilot double blind placebo controlled trial of sertraline with naltrexone in the treatment of opiate dependence. (12202015)
2002
21
An abstinence-oriented program for substance use disorders: poorer outcome associated with opiate dependence. (11190363)
2000
22
Physical health problems in depressed and nondepressed children and adolescents of parents with opiate dependence. (10207660)
1999
23
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (9702742)
1998
24
Comorbidity of opiate dependence and mental disorders. (9801715)
1998
25
Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence. (9352573)
1997
26
Management of opiate dependence. (8731632)
1996
27
Fluoxetine is ineffective for treatment of cocaine dependence or concurrent opiate and cocaine dependence: two placebo-controlled double-blind trials. (7635993)
1995
28
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
29
Formalin-induced pain antagonizes the development of opiate dependence in the rat. (8272266)
1993
30
Statistical Issues in Clinical Trials for Treatment of Opiate Dependence. Technical review. Bethesda, Maryland, December 2-3, 1991. (1436009)
1992
31
Rationale for maintenance pharmacotherapy of opiate dependence. (1346939)
1992
32
Buprenorphine for cocaine and opiate dependence. (1609037)
1992
33
Severity of opiate dependence in an Australian sample: further validation of the SODQ. (2611427)
1989
34
Discrimination of opiate dependence from opiate abstinence and methadone maintenance by use of the Derogatis scale. (3406052)
1988
35
An approach to the paradoxes of experimental opiate dependence. (3136355)
1988
36
Opiate dependence and withdrawal--a new synthesis? (3001782)
1985
37
Brokerage model rehabilitation system for opiate dependence: a behavioral analysis. (6427620)
1984
38
Classical conditioning in opiate dependence. (6434985)
1984
39
Physiological basis of opiate dependence. (6851851)
1983
40
Recent trends in opiate dependence. (435878)
1979
41
Alcohol and opiate dependence; a review. (895146)
1977
42
Prostaglandins, cyclic AMP and the mechanism of opiate dependence. (167256)
1975
43
Propranolol in the treatment of opiate dependence -- a controlled study. (1091940)
1975
44
High-dose cyclazocine therapy of opiate dependence. (4594561)
1974
45
Opiate dependence. (4424463)
1974
46
The psychodynamics of opiate dependence: a new look. (4467731)
1974
47
Opiate dependence produced by ad libitum drinking of morphine in water, saline, and sucrose vehicles. (4737307)
1973
48
Narcotic antagonists in the treatment of opiate dependence. (5566728)
1971
49
Psychological approaches to opiate dependence and self-administration by laboratory animals. (4983813)
1970
50
A cyclazocine typology in opiate dependence. (5413202)
1970

Genetic Variations for Opiate Dependence

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Expression for genes affiliated with Opiate Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opiate Dependence

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DRD2, DRD3
2
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9.8DRD2, DRD3, TH
3
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9.2BDNF, DRD2, CREB1, TH
49.2BDNF, DRD2, CREB1, TH
59.1NGF, IGF1, VEGFA
6
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9.0OPRM1, CREB1, POMC, NGF
79.0TH, NGF, SNCA, CREB1, OPRM1
8
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8.9NGF, VEGFA, CREB1, BDNF
98.7BDNF, CREB1, VEGFA, NGF, TH
108.6IGF1, VEGFA, CREB1, BDNF
11
Hide members
8.5ADCY10, COMT, DRD2, DRD3, OPRM1, CREB1
12
Hide members
8.1CCKBR, NPFF, DRD2, DRD3, OPRM1, POMC
13
Hide members
6.5CCKBR, NPFF, DRD2, DRD3, OPRM1, CREB1

Compounds for genes affiliated with Opiate Dependence

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1carbachol44 28 1112.1SNCA, ADCY10
2cycloheximide449.8ADCY10
3gnrh449.8TH, CREB1, BDNF
42,3-dideoxyadenosine449.6ADCY10, CREB1, TH
5apomorphine44 28 1111.6TH, SNCA, DRD2, DRD3, COMT
6quinpirole44 2810.5ADCY10, TH, CREB1, DRD3, DRD2
7dopac449.5COMT, BDNF, DRD3, TH
8atropine44 28 1111.5CREB1, ADCY10, NGF, SNCA
9octreotide44 59 28 1112.4ADCY10, CCKBR, DRD2, IGF1
10yohimbine44 28 2 1112.4CCKBR, DRD3, OPRM1, ADCY10, DRD2
11pramipexole44 49 28 1112.4DRD3, DRD2, BDNF, COMT, TH
12cabergoline28 44 1111.3COMT, DRD2, DRD3, IGF1
13heroin44 49 1111.3OPRM1, DRD3, POMC, DRD2, COMT
14amphetamine44 1110.3CCKBR, DRD2, SNCA, POMC, TH
15bromocriptine28 44 1111.3DRD3, CREB1, ADCY10, POMC, COMT
16ly294002449.3OPRM1, CREB1, VEGFA, NGF
17glutamate449.3DRD2, DRD3, CCKBR, SNCA, OPRM1, COMT
18risperidone28 44 49 59 11 2414.2COMT, CREB1, BDNF, DRD3, DRD2
19selegiline44 1110.2BDNF, TH, NGF, COMT, SNCA
20maoa449.2COMT, BDNF, TH, DRD2, POMC
21quetiapine44 49 28 11 2413.2DRD3, TH, BDNF, DRD2
22chelerythrine448.9OPRM1, CREB1, IGF1, ADCY10
23methadone44 49 1110.9DRD2, POMC, NGF, OPRM1, BDNF
24nicotine44 49 28 1111.9TH, NGF, OPRM1, DRD2, CCKBR, COMT
25nmda44 289.9COMT, CCKBR, OPRM1, NGF, TH, BDNF
26clozapine44 28 49 1111.9POMC, TH, COMT, BDNF, DRD2, DRD3
27catecholamine448.8COMT, BDNF, DRD3, SNCA, POMC, TH
28mptp448.8COMT, TH, BDNF, DRD2, DRD3, SNCA
29gf 109203x44 599.7ADCY10, VEGFA, NGF, OPRM1, CREB1
305-hydroxytryptamine448.7COMT, DRD2, OPRM1, CREB1, POMC, TH
31dexamethasone44 49 28 1111.5ADCY10, CREB1, VEGFA, POMC, OPRM1, TH
32methamphetamine44 49 1110.5COMT, BDNF, DRD2, DRD3, OPRM1, CREB1
33gaba448.5BDNF, CREB1, ME2, POMC, TH, OPRM1
34histamine44 28 2410.4CCKBR, CREB1, BDNF, OPRM1, NGF, TH
35sb 20358044 599.4SNCA, CCKBR, CREB1, IGF1, NGF, VEGFA
36haloperidol44 28 2 49 1112.3BDNF, CCKBR, TH, DRD2, CREB1, DRD3
376-hydroxydopamine448.2CREB1, TH, NGF, SNCA, OPRM1, DRD3
38norepinephrine44 11 2410.0OPRM1, DRD3, DRD2, BDNF, CREB1, SNCA
39glutamine447.9CCKBR, OPRM1, CREB1, SNCA, IGF1, POMC
40opiate447.9TH, ADCY10, POMC, OPRM1, DRD3, DRD2
41epinephrine44 11 249.8ADCY10, CREB1, OPRM1, DRD2, BDNF, COMT
42morphine44 49 28 1110.8COMT, CCKBR, NPFF, DRD2, OPRM1, CREB1
43cyclic amp44 248.6TH, ADCY10, OPRM1, BDNF, CREB1, NPFF
44dopamine44 28 11 2410.6DRD2, BDNF, TH, IGF1, SNCA, OPRM1
45acetylcholine44 49 28 11 2411.6POMC, NGF, CREB1, ADCY10, OPRM1, SNCA
46adenylate447.6ADCY10, TH, NGF, POMC, SNCA, CREB1
47levodopa44 118.5COMT, BDNF, DRD2, DRD3, TH, IGF1
48vegf447.5BDNF, DRD2, CREB1, VEGFA, IGF1, POMC
49cocaine44 118.4TH, NGF, POMC, SNCA, CREB1, OPRM1
50testosterone44 59 11 2410.4SNCA, TH, POMC, IGF1, CREB1, OPRM1

GO Terms for genes affiliated with Opiate Dependence

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16Gene Ontology
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Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.2TH, DRD2, NPFF
2synaptic vesicleGO:0080219.1BDNF, SNCA, TH
3dendriteGO:0304258.7ADCY10, TH, DRD2, NPFF
4extracellular regionGO:0055767.0NGF, POMC, IGF1, VEGFA, SNCA, NPFF

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD2, DRD3
2response to histamineGO:03477610.4DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.4DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.4DRD2, DRD3
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.4DRD2, DRD3
6negative regulation of dopamine metabolic processGO:04596310.3SNCA, COMT
7dopamine metabolic processGO:04241710.3DRD2, DRD3
8regulation of locomotionGO:04001210.3SNCA, DRD3
9negative regulation of protein secretionGO:05070910.3DRD2, DRD3
10G-protein coupled receptor internalizationGO:00203110.2DRD2, DRD3
11dopamine biosynthetic processGO:04241610.2TH, SNCA
12response to light stimulusGO:00941610.2TH, DRD2
13synaptic transmission, dopaminergicGO:00196310.2DRD2, DRD3, TH
14reduction of cytosolic calcium ion concentrationGO:05148110.2OPRM1, DRD2
15response to amphetamineGO:00197510.2DRD2, DRD3, TH
16behavioral response to ethanolGO:04814910.2DRD2, OPRM1
17regulation of dopamine secretionGO:01405910.2SNCA, DRD3, DRD2
18behavioral response to cocaineGO:04814810.2DRD2, DRD3, SNCA
19adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.1DRD3, OPRM1
20learningGO:00761210.1TH, DRD3, COMT
21sensory perceptionGO:00760010.1CCKBR, OPRM1
22prepulse inhibitionGO:06013410.1DRD3, DRD2
23negative regulation of adenylate cyclase activityGO:00719410.1OPRM1, DRD3, DRD2
24arachidonic acid secretionGO:05048210.0DRD2, DRD3
25neurotransmitter biosynthetic processGO:04213610.0TH, COMT
26positive regulation of renal sodium excretionGO:0358159.9DRD2, DRD3
27Type I pneumocyte differentiationGO:0605099.9CREB1, IGF1
28positive regulation of protein autophosphorylationGO:0319549.9NGF, VEGFA
29feeding behaviorGO:0076319.9BDNF, CCKBR, DRD2
30locomotory behaviorGO:0076269.8TH, OPRM1, DRD3, DRD2
31response to lipopolysaccharideGO:0324969.8TH, NGF, SNCA, COMT
32circadian regulation of gene expressionGO:0329229.7DRD2, DRD3
33response to morphineGO:0432789.6NPFF, DRD2, DRD3
34negative regulation of neuron apoptotic processGO:0435249.5BDNF, SNCA, NGF
35response to hypoxiaGO:0016669.4BDNF, DRD2, VEGFA, TH
36regulation of excitatory postsynaptic membrane potentialGO:0600799.2BDNF, NPFF, SNCA
37elevation of cytosolic calcium ion concentrationGO:0072049.1OPRM1, NPFF, CCKBR
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.6DRD2, DRD3, CREB1, VEGFA, IGF1, POMC
39response to drugGO:0424938.5NGF, COMT, NPFF, DRD2, DRD3, CREB1

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.0TH, SNCA
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD3, DRD2
3dopamine bindingGO:0352409.8TH, DRD3, DRD2
4growth factor activityGO:0080838.3BDNF, VEGFA, IGF1, NGF

Products for genes affiliated with Opiate Dependence

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Sources for Opiate Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet