MCID: OPT003
MIFTS: 54

Opiate Dependence malady

Mental diseases category

Summaries for Opiate Dependence

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Disease Ontology:9 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards based summary: Opiate Dependence, also known as opioid dependence, is related to drug dependence and substance abuse. An important gene associated with Opiate Dependence is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Melanocyte Development and Pigmentation and p38 signaling mediated by MAPKAP kinases. The compounds quinpirole and gamma-butyrolactone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:64 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Description from OMIM:46 610064

Aliases & Classifications for Opiate Dependence

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Sources:
9Disease Ontology, 46OMIM, 11DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 28ICD9CM, 34MeSH
See all sources

Opiate Dependence, Aliases & Descriptions:

Name: Opiate Dependence 9 11 61
Opioid Dependence 46 44 61
 
Opioid Type Dependence 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:2559
ICD9CM28 304.0, 304.00
MeSH34 D009293

Related Diseases for Opiate Dependence

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Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1drug dependence30.7DRD3, OPRM1
2substance abuse30.7OPRM1, DRD3
3panic disorder30.5POMC, CCKBR
4hyperglycemia30.3CREB1, IGF1, POMC
5schizophrenia29.9NGF, DRD3, CREB1, CCKBR, TH, OPRM1
6opioid abuse10.6NPFF
7cerebral hypoxia10.5CREB1
8diabetic autonomic neuropathy10.5NGF
9hyperaldosteronism10.4TH, POMC
10craniopharyngioma10.3IGF1, POMC
11sheehan syndrome10.3IGF1, POMC
12gonadal disease10.3POMC, IGF1
13bipolar disorder10.3TH, CREB1
14alcohol dependence10.3
15neuronitis10.3
16thyrotropin deficiency, isolated10.3POMC, IGF1
17withdrawal disorder10.3OPRM1, NPFF
18pituitary gland disease10.3POMC, IGF1
19movement disease10.3TH, DRD3
20panhypopituitarism10.3IGF1, POMC
21substance dependence10.3DRD3, OPRM1
22amenorrhea10.3POMC, IGF1
23rett syndrome10.3NGF, TH
24age related macular degeneration10.3VEGFA
25growth hormone deficiency10.3POMC, IGF1
26attention deficit hyperactivity disorder10.3
27conduct disorder10.3
28neonatal abstinence syndrome10.3
29precocious puberty10.3POMC, IGF1
30leydig cell tumor10.3CREB1, POMC
31hypopituitarism10.3POMC, IGF1
32hepatitis10.2
33hepatitis c10.2
34blindness10.2
35addison's disease10.2TH, POMC
36idiopathic generalized epilepsy10.2ME2
37thyroid medullary carcinoma10.2CREB1, CCKBR, POMC
38ganglioneuroma10.2NGF, POMC, TH
39parkinson's disease10.2DRD3, TH, NGF
40memory impairment10.2NGF, CREB1
41hyperprolactinemia10.2IGF1, TH, POMC
42cocaine dependence10.2OPRM1, POMC, DRD3
43chronic pain10.2
44opioid dependence 110.2
45psychotic disorder10.2DRD3, TH, OPRM1
46toxic encephalopathy10.2TH, CREB1, NGF
47prion disease10.2TH, NGF, CREB1
48huntington's disease10.2CREB1, TH, NGF
49retinopathy of prematurity10.2VEGFA, IGF1
50adrenocortical carcinoma10.2CREB1, POMC

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Symptoms for Opiate Dependence

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Clinical features from OMIM:

610064

Drugs & Therapeutics for Opiate Dependence

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Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Genetic Tests for Opiate Dependence

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Anatomical Context for Opiate Dependence

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MalaCards organs/tissues related to Opiate Dependence:

32
Testes, Brain, Endothelial

Animal Models for Opiate Dependence or affiliated genes

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MGI Mouse Phenotypes related to Opiate Dependence:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9OPRM1, DRD3, POMC, IGF1
2MP:00053678.4POMC, CCKBR, IGF1, VEGFA, DRD3
3MP:00030128.0NGF, VEGFA, POMC, OPRM1, TH
4MP:00028737.8TH, OPRM1, CREB1, VEGFA, NGF, IGF1
5MP:00053797.7OPRM1, CREB1, TH, IGF1, VEGFA, POMC
6MP:00107717.6TH, NGF, VEGFA, POMC, CCKBR, OPRM1
7MP:00053857.6DRD3, CCKBR, POMC, VEGFA, NGF, IGF1
8MP:00053867.4CCKBR, CREB1, DRD3, OPRM1, NGF, VEGFA
9MP:00107687.2TH, IGF1, NGF, VEGFA, POMC, CREB1
10MP:00036317.1POMC, OPRM1, CCKBR, DRD3, CREB1, TH
11MP:00053787.1CCKBR, POMC, VEGFA, NGF, IGF1, TH
12MP:00053767.0CREB1, DRD3, OPRM1, VEGFA, NGF, IGF1

Publications for Opiate Dependence

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Articles related to Opiate Dependence:

(show top 50)    (show all 224)
idTitleAuthorsYear
1
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. (24205275)
2013
2
Relative and age-dependent stimulation of soluble and cellular immunity in opiate dependence. (21918466)
2012
3
Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. (21920671)
2012
4
Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence. (19327850)
2011
5
The effect of pain on stroop performance in patients with opiate dependence in sustained remission. (21769047)
2011
6
Pharmacological treatments of opiate dependence. (21524267)
2011
7
Factors associated with the prescribing of buprenorphine or methadone for treatment of opiate dependence. (19004598)
2009
8
Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. (19608356)
2009
9
Economic evaluation of interventions to treat opiate dependence : a review of the evidence. (18429655)
2008
10
The neuropsychology of amphetamine and opiate dependence: implications for treatment. (17690986)
2007
11
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
12
Suicidal ideation in veterans receiving treatment for opiate dependence. (16903454)
2006
13
Profile of executive and memory function associated with amphetamine and opiate dependence. (16160707)
2006
14
Maternal deprivation specifically enhances vulnerability to opiate dependence. (17110797)
2006
15
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
16
Public policy statement on buprenorphine for opiate dependence and withdrawal. (15534969)
2004
17
Diamorphine treatment for opiate dependence: putative markers of concomitant heroin misuse. (11900600)
2001
18
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. (11122350)
2000
19
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (9702742)
1998
20
An open trial of naltrexone for opiate dependence. (16203482)
1998
21
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
22
Decreased nociceptive sensitivity: a biological risk marker for opiate dependence? (9158227)
1997
23
Management of opiate dependence. (8745858)
1996
24
Use of morphine mixture to stabilize opiate dependence. (16203402)
1996
25
Opiate dependence, comorbidity and seasonality of birth. (8555277)
1995
26
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
27
A Markov model for NIDA data on treatment of opiate dependence. (1436013)
1992
28
Nasal administration of naloxone for detection of opiate dependence. (1560408)
1992
29
Analysis of clinical trials for treatment of opiate dependence: what are the possibilities? (1436010)
1992
30
Neurobiological mechanisms in cocaine and opiate dependence. (1311123)
1992
31
Statistical Issues in Clinical Trials for Treatment of Opiate Dependence. Technical review. Bethesda, Maryland, December 2-3, 1991. (1436009)
1992
32
New trends in infant pain management: potential for opiate dependence. (1876111)
1990
33
Discrimination of opiate dependence from opiate abstinence and methadone maintenance by use of the Derogatis scale. (3406052)
1988
34
The opiate dependence syndrome: replication study using the SODQ in a New York clinic. (3207935)
1988
35
Naltrexone in the treatment of opiate dependence. (3580701)
1987
36
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (2874232)
1986
37
The effect of tolerance on opiate dependence as measured by the adenylate cyclase rebound response to naloxone in the NG108-15 model system. (6099517)
1984
38
Physiological basis of opiate dependence. (6851851)
1983
39
Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence. (6126814)
1982
40
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
41
Propoxyphene napsylate compared to methadone for opiate dependence. (6122232)
1981
42
Recent trends in opiate dependence. (435878)
1979
43
Recent trends in opiate dependence. (455022)
1979
44
Agonist--antagonist properties of phenoxybenzamine in antinociception and opiate dependence tests. (572775)
1979
45
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
46
Naltrexone in the treatment of opiate dependence. (218108)
1978
47
Trends in methadone use in the treatment of opiate dependence in Canada. (872016)
1977
48
Prostaglandins, cyclic AMP and the mechanism of opiate dependence. (167256)
1975
49
Naloxone treatment of opiate dependence. A progress report. (5108223)
1971
50
Narcotic antagonists in opiate dependence. (4914724)
1970

Variations for Opiate Dependence

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Expression for genes affiliated with Opiate Dependence

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Expression patterns in normal tissues for genes affiliated with Opiate Dependence

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

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Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8POMC, CREB1
29.8TH, CREB1
39.7CREB1, NGF
4
Show member pathways
9.6POMC, VEGFA
59.0CREB1, IGF1, VEGFA
6
Show member pathways
Signaling Pathways in Glioblastoma37
9.0VEGFA, IGF1, CREB1
79.0IGF1, VEGFA, NGF
8
Show member pathways
9.0OPRM1, DRD3, CREB1, TH
9
Show member pathways
8.9CCKBR, NPFF, CREB1
10
Show member pathways
8.9OPRM1, NGF, POMC, CREB1
118.9OPRM1, CREB1, TH, NGF
12
Show member pathways
Peptide GPCRs37
8.8OPRM1, NPFF, CCKBR
138.7VEGFA, NGF, TH, CREB1
148.6IGF1, CREB1, NGF, VEGFA
15
Show member pathways
8.2OPRM1, CCKBR, NPFF, DRD3, POMC
16
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.1NGF, VEGFA, CREB1, OPRM1, IGF1
17
Show member pathways
6.3NGF, DRD3, OPRM1, NPFF, VEGFA, CCKBR

Compounds for genes affiliated with Opiate Dependence

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Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1quinpirole44 2910.8DRD3, CREB1, TH
2gamma-butyrolactone449.8TH, DRD3
3heroin44 50 1211.7POMC, DRD3, OPRM1
4yohimbine44 3 29 1212.6OPRM1, DRD3, CCKBR
5methadone50 44 1211.5NGF, POMC, OPRM1
6naltrexone44 29 50 1212.5IGF1, POMC, OPRM1
7desipramine44 50 1211.5CREB1, NGF, TH
8bromocriptine44 29 1211.5IGF1, POMC, CREB1, DRD3
9mptp449.5DRD3, NGF, TH
10naloxone44 29 50 1212.4POMC, CREB1, OPRM1
11valproate449.4CREB1, IGF1, TH
12amphetamine44 50 1211.4TH, POMC, CCKBR, OPRM1
13methamphetamine44 50 1211.4OPRM1, DRD3, CREB1, TH
14chelerythrine449.4IGF1, CREB1, OPRM1
15deltorphin i449.3NPFF, OPRM1
165-hydroxytryptamine449.3OPRM1, CREB1, POMC, TH
17acth449.2CREB1, CCKBR, POMC, IGF1
18octreotide44 60 29 1212.2CCKBR, POMC, VEGFA, IGF1
19progestin449.1POMC, VEGFA, IGF1, TH
20gaba449.1TH, POMC, ME2, CREB1, OPRM1
21nicotine44 29 50 1212.0TH, NGF, CCKBR, DRD3, OPRM1
226-hydroxydopamine449.0TH, NGF, CREB1, DRD3, OPRM1
23epinephrine44 25 1210.9TH, NGF, POMC, CREB1, OPRM1
24clonidine44 50 29 1211.9OPRM1, POMC, IGF1
25gf 109203x44 609.9NGF, VEGFA, CREB1, OPRM1
26histamine44 29 2510.9TH, NGF, CCKBR, CREB1, OPRM1
27tetrapeptide448.8NPFF, OPRM1, CCKBR
28haloperidol44 50 29 3 1212.8TH, POMC, CCKBR, CREB1, DRD3, OPRM1
29norepinephrine44 25 1210.7TH, NGF, POMC, CREB1, DRD3, OPRM1
30nmda44 299.7TH, NGF, CCKBR, CREB1, DRD3, OPRM1
31actinomycin d448.6TH, IGF1, NGF, VEGFA, CREB1
32sb 20358044 609.6IGF1, NGF, VEGFA, CCKBR, CREB1
33acetylcholine44 50 29 25 1212.6TH, NGF, POMC, CCKBR, CREB1, OPRM1
34adenylate448.6TH, NGF, POMC, CCKBR, CREB1, OPRM1
35levodopa44 129.6TH, IGF1, NGF, CREB1, DRD3, OPRM1
36glutamate448.5OPRM1, DRD3, CREB1, CCKBR, NGF, TH
37gnrh448.5TH, IGF1, NGF, POMC, CREB1, OPRM1
38cycloheximide448.5IGF1, NGF, VEGFA, POMC, CREB1
39testosterone44 60 25 1211.5TH, IGF1, NGF, POMC, CREB1, OPRM1
40cocaine44 129.4OPRM1, TH, NGF, POMC, CCKBR, CREB1
41vegf448.3TH, IGF1, NGF, VEGFA, POMC, CREB1
42opiate448.3TH, POMC, CREB1, DRD3, OPRM1, NPFF
43ly294002448.2TH, IGF1, NGF, VEGFA, CREB1, OPRM1
44glutamine448.2TH, IGF1, NGF, POMC, CCKBR, CREB1
45cyclic amp44 259.1TH, NGF, CREB1, DRD3, OPRM1, NPFF
46morphine44 50 29 1211.1TH, NGF, CCKBR, CREB1, OPRM1, NPFF
47serine448.1IGF1, NGF, POMC, CCKBR, CREB1, DRD3
48dopamine44 29 25 1210.9TH, IGF1, NGF, POMC, CCKBR, CREB1
49dexamethasone44 50 29 1210.9TH, IGF1, NGF, VEGFA, POMC, CREB1
50tyrosine447.9TH, IGF1, NGF, VEGFA, CCKBR, CREB1

GO Terms for genes affiliated with Opiate Dependence

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Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9NGF, VEGFA, POMC, NPFF, IGF1
2extracellular spaceGO:0056157.6NPFF, POMC, VEGFA, NGF, IGF1

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:00196310.2TH, DRD3
2response to amphetamineGO:00197510.0TH, DRD3
3response to electrical stimulusGO:05160210.0NGF, TH
4adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.0OPRM1, DRD3
5Type I pneumocyte differentiationGO:06050910.0IGF1, CREB1
6regulation of multicellular organism growthGO:04001410.0DRD3, IGF1
7sensory perceptionGO:00760010.0OPRM1, CCKBR
8positive regulation of mitosisGO:0458409.9IGF1, DRD3
9social behaviorGO:0351769.9TH, DRD3
10negative regulation of adenylate cyclase activityGO:0071949.9DRD3, OPRM1
11eye photoreceptor cell developmentGO:0424629.8VEGFA, TH
12positive regulation of protein autophosphorylationGO:0319549.8VEGFA, NGF
13response to peptide hormoneGO:0434349.7NGF, TH
14extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7NGF, IGF1
15locomotory behaviorGO:0076269.7OPRM1, DRD3, TH
16heart morphogenesisGO:0030079.7VEGFA, TH
17response to morphineGO:0432789.6NPFF, DRD3
18branching morphogenesis of an epithelial tubeGO:0487549.6IGF1, VEGFA
19phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.6CCKBR, OPRM1
20learningGO:0076129.6DRD3, TH
21phosphatidylinositol-mediated signalingGO:0480159.5IGF1, NGF, CREB1
22lactationGO:0075959.4CREB1, VEGFA
23neuropeptide signaling pathwayGO:0072189.2POMC, OPRM1, NPFF
24positive regulation of cytosolic calcium ion concentrationGO:0072049.1NPFF, OPRM1, CCKBR
25positive regulation of cell proliferationGO:0082849.1DRD3, CCKBR, VEGFA, IGF1
26response to drugGO:0424939.0NPFF, NGF, CREB1, DRD3
27positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IGF1, VEGFA, POMC, CREB1, DRD3

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8DRD3, TH
2G-protein coupled receptor bindingGO:0016649.4NPFF, POMC
3growth factor activityGO:0080838.7VEGFA, NGF, IGF1

Products for genes affiliated with Opiate Dependence

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Sources for Opiate Dependence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet