MCID: OPT003
MIFTS: 51

Opiate Dependence malady

Summaries for Opiate Dependence

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.

MalaCards: Opiate Dependence, also known as opioid dependence, is related to alcohol dependence and heroin dependence. An important gene associated with Opiate Dependence is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Dopamine receptors and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds carbachol and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:64 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Description from OMIM:47 610064

Aliases & Classifications for Opiate Dependence

Sources:
8Disease Ontology, 10DISEASES, 47OMIM, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

opiate dependence 8 10
opioid dependence 47 45
opioid type dependence 8


External Ids:

Disease Ontology8 DOID:2559
ICD9CM27 304.0, 304.00
MeSH35 D009293

Related Diseases for Opiate Dependence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Opiate Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.7DRD2, OPRM1
2heroin dependence30.7DRD2
3cocaine dependence30.6POMC, OPRM1, DRD3, DRD2
4substance dependence30.4OPRM1, DRD3, COMT, DRD2
5opioid abuse30.4NPFF
6conduct disorder30.4COMT, DRD2
7attention deficit hyperactivity disorder30.4BDNF, COMT, DRD2
8substance abuse30.2OPRM1, DRD3, DRD2
9sudden infant death syndrome30.1TH
10anxiety disorder30.1BDNF
11nicotine dependence30.0DRD2
12cocaine abuse30.0DRD2
13panic disorder30.0POMC, CCKBR
14morphine dependence10.5
15opioid dependence 110.3
16cannabis dependence10.2
17hepatitis d10.2
18hepatitis e10.2
19neonatal abstinence syndrome10.2
20n syndrome10.2
21hepatitis c10.1
22dependent personality disorder10.1
23borderline personality disorder10.1
24hepatitis b10.1
25premature ejaculation10.1
26hepatitis a10.1
27brainstem auditory evoked responses10.1
28chronic pain10.1
29hepatitis c virus10.1
30t-cell leukemia10.0
31tuberculosis10.0
32viral hepatitis10.0
33myoclonus10.0
34restless legs syndrome10.0DRD2
35delusional disorder10.0DRD2
36fibromyalgia10.0COMT
37myocardial infarction10.0COMT
38myoclonus-dystonia10.0DRD2
39thyroid cancer10.0CCKBR
40atopic dermatitis10.0NGF
41hepatitis10.0COMT
42paranoid schizophrenia10.0COMT
43gastrinoma10.0CCKBR
44leiomyoma10.0COMT
45dysautonomia10.0SNCA
46hyperparathyroidism10.0ADCY10
47neuropathy10.0NGF
48encephalomyelitis10.0NGF
49blindness10.0VEGFA
50pure autonomic failure10.0SNCA

Graphical network of the top 20 diseases related to Opiate Dependence:



Diseases related to opiate dependence

Clinical Features for Opiate Dependence

Sources:
47OMIM
See all sources

Clinical features from OMIM:

610064

Drugs & Therapeutics for Opiate Dependence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Opiate Dependence

Drug clinical trials:

Search ClinicalTrials for Opiate Dependence

Search NIH Clinical Center for Opiate Dependence

Search CenterWatch for Opiate Dependence

Genetic Tests for Opiate Dependence

Anatomical Context for Opiate Dependence

Animal Models for Opiate Dependence or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Opiate Dependence

Sources:
51PubMed
See all sources

Articles related to Opiate Dependence:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
Estimation of BDNF gene polymorphism and predisposition to dependence development for selected psychoactive compounds: genetic aspects of addiction with the selected drugs, amphetamine, tetrahydrocannabinol and opiates. (23111884)
2013
2
Manifold implications of forgotten hyperglycemia in clinical opiate dependence. (22313373)
2013
3
Relative and age-dependent stimulation of soluble and cellular immunity in opiate dependence. (21918466)
2012
4
Pharmacological treatments of opiate dependence. (21524267)
2011
5
A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study. (22208661)
2011
6
Differences between men and women in the course of opiate dependence: is there a telescoping effect? (19838765)
2010
7
Estimation of cutoff for the Severity of Dependence Scale (SDS) for opiate dependence by ROC analysis. (21117001)
2010
8
Rhesus macaque model of chronic opiate dependence and neuro-AIDS: longitudinal assessment of auditory brainstem responses and visual evoked potentials. (19283490)
2009
9
Executive functions and risky decision-making in patients with opiate dependence. (18485620)
2008
10
The neuropsychology of amphetamine and opiate dependence: implications for treatment. (17690986)
2007
11
Suicide attempts among individuals with opiate dependence: the critical role of belonging. (17097813)
2007
12
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence. (16639097)
2005
13
What are America's opportunities for harm reduction strategies in opiate dependence? (16188710)
2005
14
Opiate dependence treatment with buprenorphine: one year's experience in a family practice residency setting. (15784521)
2005
15
The effectiveness of community maintenance with methadone or buprenorphine for treating opiate dependence. (15720937)
2005
16
Test-retest reliability of the Temperament and Character Inventory in patients with opiate dependence. (12759164)
2003
17
Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study. (11826132)
2002
18
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice. (11276224)
2001
19
Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats. (10943688)
2000
20
An abstinence-oriented program for substance use disorders: poorer outcome associated with opiate dependence. (11190363)
2000
21
Effect of nitric oxide synthase inhibitor on signal transduction pathway of opiate tolerance and dependence in NG108-15 cells expressing iNOS gene]. (11715524)
1999
22
Psychiatric disorders in first-degree relatives of patients with opiate dependence. (10466316)
1999
23
An open trial of naltrexone for opiate dependence. (16203482)
1998
24
Psychopathology in children of parents with opiate dependence and/or major depression. (9808925)
1998
25
Management of opiate dependence. (8745858)
1996
26
Management of opiate dependence. (8731632)
1996
27
Opiate dependence, comorbidity and seasonality of birth. (8555277)
1995
28
Management of opiate dependence. (8745871)
1995
29
Formalin-induced pain antagonizes the development of opiate dependence in the rat. (8272266)
1993
30
A Markov model for NIDA data on treatment of opiate dependence. (1436013)
1992
31
Design of clinical trials for treatment of opiate dependence: what is missing? (1436014)
1992
32
Use of naloxone in the assessment of opiate dependence. (1943484)
1991
33
Opiate dependence--the role of benzodiazepines. (1968829)
1990
34
A multicentre study to introduce naltrexone for opiate dependence in Spain. (2702921)
1989
35
Severity of opiate dependence in an Australian sample: further validation of the SODQ. (2611427)
1989
36
An approach to the paradoxes of experimental opiate dependence. (3136355)
1988
37
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (2874232)
1986
38
Methadone treatment of opiate dependence in Canada. (3864480)
1985
39
Opiate dependence and withdrawal--a new synthesis? (3001782)
1985
40
Multiple family therapy and naltrexone in the treatment of opiate dependence. (7318681)
1981
41
Propoxyphene napsylate compared to methadone for opiate dependence. (6122232)
1981
42
Preliminary communication: cessation of opiate dependence: processes involved in achieving abstinence. (281960)
1978
43
Neuronal aspects of opiate dependence and tolerance in comparison to central depressants. (22993)
1977
44
Biochemical and physiological approaches to opiate dependence. (15951)
1976
45
Propranolol in the treatment of opiate dependence -- a controlled study. (1091940)
1975
46
Rating the presence and severity of opiate dependence. (4422361)
1974
47
The psychodynamics of opiate dependence: a new look. (4467731)
1974
48
Pharmacological adjuncts in the treatment of opiate dependence. (4447422)
1974
49
Naloxone-methadone combination for the treatment of opiate dependence. (4612373)
1973
50
Methadone maintenance for opiate dependence. (5486539)
1970

Genetic Variations for Opiate Dependence

Expression for genes affiliated with Opiate Dependence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Opiate Dependence

Search GEO for disease gene expression data for Opiate Dependence.

Pathways for genes affiliated with Opiate Dependence

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DRD3, DRD2
2
Hide members
9.8DRD2, DRD3, TH
3
Hide members
9.2BDNF, DRD2, TH, CREB1
49.2CREB1, BDNF, DRD2, TH
59.1IGF1, VEGFA, NGF
6
Hide members
9.0CREB1, NGF, POMC, OPRM1
79.0OPRM1, CREB1, TH, NGF, SNCA
8
Hide members
8.9BDNF, CREB1, NGF, VEGFA
98.7TH, VEGFA, CREB1, BDNF, NGF
108.6VEGFA, IGF1, CREB1, BDNF
11
Hide members
8.5DRD3, ADCY10, TH, OPRM1, CREB1, COMT
12
Hide members
8.1DRD3, OPRM1, POMC, NPFF, CCKBR, DRD2
13
Hide members
6.5NGF, VEGFA, CREB1, OPRM1, DRD2, NPFF

Compounds for genes affiliated with Opiate Dependence

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Opiate Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1carbachol45 29 1112.1SNCA, ADCY10
2cycloheximide459.8ADCY10
3gnrh459.8TH, CREB1, BDNF
42,3-dideoxyadenosine459.6ADCY10, CREB1, TH
5apomorphine45 29 1111.6TH, SNCA, DRD2, DRD3, COMT
6quinpirole45 2910.5ADCY10, TH, CREB1, DRD3, DRD2
7dopac459.5COMT, BDNF, DRD3, TH
8atropine45 29 1111.5CREB1, ADCY10, NGF, SNCA
9octreotide45 60 29 1112.4ADCY10, CCKBR, DRD2, IGF1
10yohimbine45 29 2 1112.4CCKBR, DRD3, OPRM1, ADCY10, DRD2
11pramipexole45 50 29 1112.4DRD3, DRD2, BDNF, COMT, TH
12cabergoline29 45 1111.3COMT, DRD2, DRD3, IGF1
13heroin45 50 1111.3OPRM1, DRD3, POMC, DRD2, COMT
14amphetamine45 1110.3CCKBR, DRD2, SNCA, POMC, TH
15bromocriptine29 45 1111.3DRD3, CREB1, ADCY10, POMC, COMT
16ly294002459.3OPRM1, CREB1, VEGFA, NGF
17glutamate459.3DRD2, DRD3, CCKBR, SNCA, OPRM1, COMT
18risperidone29 45 50 60 11 2414.2COMT, CREB1, BDNF, DRD3, DRD2
19selegiline45 1110.2BDNF, TH, NGF, COMT, SNCA
20maoa459.2COMT, BDNF, TH, DRD2, POMC
21quetiapine45 50 29 11 2413.2DRD3, TH, BDNF, DRD2
22chelerythrine458.9OPRM1, CREB1, IGF1, ADCY10
23methadone45 50 1110.9DRD2, POMC, NGF, OPRM1, BDNF
24nicotine45 50 29 1111.9TH, NGF, OPRM1, DRD2, CCKBR, COMT
25nmda45 299.9COMT, CCKBR, OPRM1, NGF, TH, BDNF
26clozapine45 29 50 1111.9POMC, TH, COMT, BDNF, DRD2, DRD3
27catecholamine458.8COMT, BDNF, DRD3, SNCA, POMC, TH
28mptp458.8COMT, TH, BDNF, DRD2, DRD3, SNCA
29gf 109203x45 609.7ADCY10, VEGFA, NGF, OPRM1, CREB1
305-hydroxytryptamine458.7COMT, DRD2, OPRM1, CREB1, POMC, TH
31dexamethasone45 50 29 1111.5ADCY10, CREB1, VEGFA, POMC, OPRM1, TH
32methamphetamine45 50 1110.5COMT, BDNF, DRD2, DRD3, OPRM1, CREB1
33gaba458.5BDNF, CREB1, ME2, POMC, TH, OPRM1
34histamine45 29 2410.4CCKBR, CREB1, BDNF, OPRM1, NGF, TH
35sb 20358045 609.4SNCA, CCKBR, CREB1, IGF1, NGF, VEGFA
36haloperidol45 29 2 50 1112.3BDNF, CCKBR, TH, DRD2, CREB1, DRD3
376-hydroxydopamine458.2CREB1, TH, NGF, SNCA, OPRM1, DRD3
38norepinephrine45 11 2410.0OPRM1, DRD3, DRD2, BDNF, CREB1, SNCA
39glutamine457.9CCKBR, OPRM1, CREB1, SNCA, IGF1, POMC
40opiate457.9TH, ADCY10, POMC, OPRM1, DRD3, DRD2
41epinephrine45 11 249.8ADCY10, CREB1, OPRM1, DRD2, BDNF, COMT
42morphine45 50 29 1110.8COMT, CCKBR, NPFF, DRD2, OPRM1, CREB1
43cyclic amp45 248.6TH, ADCY10, OPRM1, BDNF, CREB1, NPFF
44dopamine45 29 11 2410.6DRD2, BDNF, TH, IGF1, SNCA, OPRM1
45acetylcholine45 50 29 11 2411.6POMC, NGF, CREB1, ADCY10, OPRM1, SNCA
46adenylate457.6ADCY10, TH, NGF, POMC, SNCA, CREB1
47levodopa45 118.5COMT, BDNF, DRD2, DRD3, TH, IGF1
48vegf457.5BDNF, DRD2, CREB1, VEGFA, IGF1, POMC
49cocaine45 118.4TH, NGF, POMC, SNCA, CREB1, OPRM1
50testosterone45 60 11 2410.4SNCA, TH, POMC, IGF1, CREB1, OPRM1

GO Terms for genes affiliated with Opiate Dependence

Sources:
16Gene Ontology
See all sources

Cellular components related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.2NPFF, DRD2, TH
2synaptic vesicleGO:0080219.1BDNF, SNCA, TH
3dendriteGO:0304258.7NPFF, DRD2, TH, ADCY10
4extracellular regionGO:0055767.0BDNF, NPFF, SNCA, VEGFA, IGF1, POMC

Biological processes related to Opiate Dependence according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.4DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD3, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.4DRD3, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.4DRD2, DRD3
5regulation of cAMP metabolic processGO:03081410.4DRD3, DRD2
6negative regulation of dopamine metabolic processGO:04596310.3COMT, SNCA
7dopamine metabolic processGO:04241710.3DRD3, DRD2
8regulation of locomotionGO:04001210.3SNCA, DRD3
9G-protein coupled receptor internalizationGO:00203110.3DRD2, DRD3
10negative regulation of protein secretionGO:05070910.2DRD3, DRD2
11dopamine biosynthetic processGO:04241610.2TH, SNCA
12synaptic transmission, dopaminergicGO:00196310.2TH, DRD2, DRD3
13reduction of cytosolic calcium ion concentrationGO:05148110.2OPRM1, DRD2
14response to light stimulusGO:00941610.2DRD2, TH
15response to amphetamineGO:00197510.2TH, DRD2, DRD3
16behavioral response to ethanolGO:04814910.2DRD2, OPRM1
17adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.2DRD3, OPRM1
18regulation of dopamine secretionGO:01405910.2SNCA, DRD3, DRD2
19behavioral response to cocaineGO:04814810.2DRD3, SNCA, DRD2
20learningGO:00761210.1COMT, DRD3, TH
21sensory perceptionGO:00760010.1CCKBR, OPRM1
22prepulse inhibitionGO:06013410.1DRD3, DRD2
23negative regulation of adenylate cyclase activityGO:00719410.1DRD3, DRD2, OPRM1
24positive regulation of renal sodium excretionGO:03581510.0DRD2, DRD3
25neurotransmitter biosynthetic processGO:04213610.0TH, COMT
26positive regulation of protein autophosphorylationGO:0319549.9VEGFA, NGF
27circadian regulation of gene expressionGO:0329229.9DRD2, DRD3
28Type I pneumocyte differentiationGO:0605099.9IGF1, CREB1
29feeding behaviorGO:0076319.9CCKBR, BDNF, DRD2
30locomotory behaviorGO:0076269.8TH, OPRM1, DRD2, DRD3
31response to lipopolysaccharideGO:0324969.8NGF, TH, SNCA, COMT
32arachidonic acid secretionGO:0504829.7DRD3, DRD2
33response to morphineGO:0432789.6DRD2, DRD3, NPFF
34negative regulation of neuron apoptotic processGO:0435249.5BDNF, SNCA, NGF
35response to hypoxiaGO:0016669.4TH, VEGFA, DRD2, BDNF
36regulation of excitatory postsynaptic membrane potentialGO:0600799.2SNCA, NPFF, BDNF
37elevation of cytosolic calcium ion concentrationGO:0072049.1OPRM1, CCKBR, NPFF
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.6POMC, DRD3, IGF1, DRD2, VEGFA, CREB1
39response to drugGO:0424938.5SNCA, DRD2, NGF, COMT, CREB1, NPFF

Molecular functions related to Opiate Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.0TH, SNCA
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD3, DRD2
3dopamine bindingGO:0352409.8DRD2, DRD3, TH
4growth factor activityGO:0080838.3VEGFA, IGF1, NGF, BDNF

Products for genes affiliated with Opiate Dependence

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Sources for Opiate Dependence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet