Summaries for Opioid Abuse

About this section


Disease Ontology:10 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards based summary: Opioid Abuse is related to hiv-1 and chronic pain. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Pathway and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related mouse phenotypes are no phenotypic analysis and nervous system.

Aliases & Classifications for Opioid Abuse

About this section

Opioid Abuse, Aliases & Descriptions:

Name: Opioid Abuse 10 12 45 62


External Ids:

Disease Ontology10 DOID:11206
SNOMED-CT57 5602001
ICD9CM29 305.5

Related Diseases for Opioid Abuse

About this section

Graphical network of the top 20 diseases related to Opioid Abuse:



Diseases related to opioid abuse

Symptoms for Opioid Abuse

About this section

Drugs & Therapeutics for Opioid Abuse

About this section

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Genetic Tests for Opioid Abuse

About this section

Anatomical Context for Opioid Abuse

About this section

MalaCards organs/tissues related to Opioid Abuse:

33
Brain, Heart

Animal Models for Opioid Abuse or affiliated genes

About this section

MGI Mouse Phenotypes related to Opioid Abuse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1OPRM1, MAPK10, CCK
2MP:00036317.4OPRM1, GRIN3B, MAPK10, CCK, FRS2

Publications for Opioid Abuse

About this section

Articles related to Opioid Abuse:

(show top 50)    (show all 148)
idTitleAuthorsYear
1
The Fentanyl Patch Boil-Up - A Novel Method of Opioid Abuse. (25892448)
2015
2
Preventing prescription opioid abuse--reply. (25756451)
2015
3
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
2014
4
Opioid Abuse and Dependence during Pregnancy: Temporal Trends and Obstetrical Outcomes. (25405293)
2014
5
The opioid abuse and misuse epidemic: implications for pharmacists in hospitals and health systems. (25174015)
2014
6
New labels to curb opioid abuse. (25157060)
2014
7
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
8
Prescription Opioid Abuse and Tampering in the United States: Results of a Self-Report Survey. (24931057)
2014
9
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
10
Estimating the costs of opioid abuse and dependence from an employer perspective: a retrospective analysis using administrative claims data. (24919646)
2014
11
The prescription opioid abuse epidemic in rural America: A look at how it begins. (25162602)
2014
12
The ecology of prescription opioid abuse in the USA: geographic variation in patients' use of multiple prescribers ("doctor shopping"). (25111716)
2014
13
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
14
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
15
Perioperative pain therapy in opioid abuse. (23241915)
2013
16
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
17
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
18
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
19
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
20
Medications development for opioid abuse. (23125072)
2013
21
Tackling prescription opioid abuse. (23437581)
2013
22
Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. (22747546)
2012
23
Opioid abuse and pain management. (23062086)
2012
24
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
25
Opioid abuse among nurse anesthetists and anesthesiologists. (22586881)
2012
26
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
27
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
28
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
29
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
30
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
31
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
32
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
33
Reducing opioid abuse and diversion. (21791685)
2011
34
Reducing opioid abuse and diversion. (21791684)
2011
35
The anesthetic implications of illicit opioid abuse. (21239906)
2011
36
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
37
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
38
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
39
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
40
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
41
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
42
Prescription opioid abuse among enrollees into methadone maintenance treatment. (17386981)
2007
43
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
44
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
45
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
46
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
47
Opioid abuse and cognitive performance. (15845327)
2005
48
Opioid abuse and brain gene expression. (15464044)
2004
49
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
50
Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. (16902682)
2001

Variations for Opioid Abuse

About this section

Expression for genes affiliated with Opioid Abuse

About this section

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

About this section

Pathways related to Opioid Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MAPK10, CCK
2
Show member pathways
9.4NPFF, CCK
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4MAPK10, FRS2
4
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.4MAPK10, FRS2
5
Show member pathways
Development Flt3 signaling60
9.4FRS2, MAPK10
69.4FRS2, MAPK10
7
Show member pathways
Peptide GPCRs38
9.4NPFF, OPRM1
8
Show member pathways
8.7MAPK10, GRIN3B, OPRM1
9
Show member pathways
8.5NPFF, OPRM1, CCK, FRS2
10
Show member pathways
8.2NPFF, OPRM1, GRIN3B, CCK

Compounds for genes affiliated with Opioid Abuse

About this section

Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dermorphin4510.0OPRM1, CCK
2loperamide45 26 1312.0OPRM1, CCK
3ondansetron51 45 26 1313.0OPRM1, CCK
4naloxone45 30 51 1312.9OPRM1, CCK
5amphetamine45 51 1311.9CCK, OPRM1
6etorphine45 30 1311.9OPRM1, MAPK10
7amide459.9OPRM1, CCK
8chelerythrine459.8OPRM1, MAPK10
9npff459.8CCK, NPFF
10pertussis459.8MAPK10, OPRM1
11cocaine45 1310.8OPRM1, CCK
12deltorphin i459.8NPFF, OPRM1
13naltrindole45 3010.8NPFF, OPRM1
14anisomycin45 1310.8OPRM1, MAPK10
15levodopa45 1310.7MAPK10, OPRM1
165-hydroxytryptamine459.7CCK, OPRM1
17ibmx45 61 3011.7CCK, MAPK10
18gf 109203x45 6110.7OPRM1, MAPK10
19carbachol45 30 1311.7MAPK10, CCK
20carbon459.7OPRM1, CCK
21phenylalanine459.5CCK, FRS2
22halothane45 51 30 1312.5GRIN3B, OPRM1
23nicotine45 30 51 1312.5OPRM1, MAPK10
24norepinephrine45 26 1311.5CCK, MAPK10, OPRM1
25histamine45 30 2611.5OPRM1, MAPK10, CCK
26thapsigargin45 6110.4CCK, MAPK10
27acetylcholine45 51 30 26 1313.4CCK, MAPK10, OPRM1
28glutamine459.4CCK, MAPK10, OPRM1
29pge2459.4OPRM1, MAPK10, CCK
30tetrapeptide459.4CCK, OPRM1, NPFF
31opiate459.4CCK, OPRM1, NPFF
32adenylate459.4OPRM1, MAPK10, CCK
335fluorouracil459.2MAPK10, CCK
34cyclic amp45 2610.2MAPK10, OPRM1, NPFF
35nmda45 3010.1MAPK10, GRIN3B, OPRM1
36morphine45 51 30 1311.9NPFF, OPRM1, MAPK10, CCK
37calcium45 51 26 1311.0CCK, MAPK10, GRIN3B, OPRM1, NPFF

GO Terms for genes affiliated with Opioid Abuse

About this section

Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:00432049.4NPFF, CCK
2dendriteGO:00304258.3NPFF, GRIN3B, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:00320999.6NPFF, CCK
2regulation of sensory perception of painGO:00519309.5NPFF, CCK
3activation of MAPK activityGO:00001879.4MAPK10, FRS2
4Fc-epsilon receptor signaling pathwayGO:00380959.4MAPK10, FRS2
5neuropeptide signaling pathwayGO:00072189.3OPRM1, NPFF
6positive regulation of cytosolic calcium ion concentrationGO:00072049.1NPFF, OPRM1

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Opioid Abuse

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet