MCID: OPD001
MIFTS: 33

Opioid Abuse malady

Summaries for Opioid Abuse

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Sources:
8Disease Ontology, 32MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards: Opioid Abuse is related to cocaine abuse and alcohol abuse. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Family Ligands and Receptor Interactions and Development FGF-family signaling. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype nervous system.

Aliases & Classifications for Opioid Abuse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

opioid abuse 8 10 44 60


External Ids:

Disease Ontology8 DOID:11206
SNOMED-CT56 5602001
ICD9CM27 305.5

Related Diseases for Opioid Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Opioid Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1cocaine abuse10.2
2alcohol abuse10.1
3cerebritis10.1
4pain disorder10.1
5cannabis abuse10.1
6substance abuse10.1
7morphine dependence10.0CCK
8neuroblastoma10.0OPRM1
9colon cancer10.0MAPK10
10ileus10.0OPRM1
11neuroepithelioma10.0CCK, MAPK10
12withdrawal disorder10.0OPRM1, NPFF
13opiate dependence10.0OPRM1, NPFF
14galactosemia10.0OPRM1, CCK
15psychotic disorder10.0CCK, OPRM1
16insulin resistance10.0MAPK10, OPRM1
17pain agnosia10.0OPRM1, NPFF, CCK
18constipation10.0OPRM1, CCK

Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Clinical Features for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opioid Abuse

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Search CenterWatch for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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Sources:
32MalaCards
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MalaCards organs/tissues related to Opioid Abuse:

32
Brain

Animal Models for Opioid Abuse or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Opioid Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7FRS2, MAPK10, GRIN3B, OPRM1, CCK

Publications for Opioid Abuse

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Sources:
50PubMed
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Articles related to Opioid Abuse:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
2
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
3
"I'm not abusing or anything": patient-physician communication about opioid treatment in chronic pain. (23916677)
2013
4
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
5
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
6
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
7
Medications development for opioid abuse. (23125072)
2013
8
The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals with Chronic Non-cancer Pain: The Role of Opioid Prescription. (24281273)
2013
9
Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone. (23707283)
2013
10
Comparison of the Risks of Shopping Behavior and Opioid Abuse Between Tapentadol and Oxycodone and Association of Shopping Behavior and Opioid Abuse. (24370606)
2013
11
Micromorphological changes in cardiac tissue of drug-related deaths with emphasis on chronic illicit opioid abuse. (23297783)
2013
12
Prevalence of Diagnosed Opioid Abuse and its Economic Burden in the Veterans Health Administration. (23809020)
2013
13
Comparison of the risks of opioid abuse or dependence between tapentadol and oxycodone: results from a cohort study. (23850177)
2013
14
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
15
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
16
Clinical strategies for the primary health care professional to minimize prescription opioid abuse. (22691907)
2012
17
Prevention of opioid abuse in chronic non-cancer pain: an algorithmic, evidence based approach. (22786456)
2012
18
Clinical differences between opioid abuse classes ameliorated after 1 year of buprenorphine-medication assisted treatment. (22540432)
2012
19
A model to identify patients at risk for prescription opioid abuse, dependence, and misuse. (22845054)
2012
20
Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse. (22778118)
2012
21
Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome. (22517450)
2012
22
Reducing opioid abuse and diversion. (21791685)
2011
23
Reducing opioid abuse and diversion. (21791684)
2011
24
Typologies of prescription opioid use in a large sample of adults assessed for substance abuse treatment. (22087270)
2011
25
Can prescription drug monitoring programs help limit opioid abuse? (22110107)
2011
26
Reducing opioid abuse and diversion. (21791683)
2011
27
Herbal medicines: perfect garb for opioid abuse? A case series from India. (21314761)
2011
28
The locus coeruleus: A key nucleus where stress and opioids intersect to mediate vulnerability to opiate abuse. (19765557)
2010
29
Variation among state-level approaches to addressing alcohol abuse in opioid treatment programs. (20418050)
2010
30
Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies. (20665209)
2010
31
Geographic information systems and pharmacoepidemiology: using spatial cluster detection to monitor local patterns of prescription opioid abuse. (20535759)
2010
32
The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. (20352414)
2010
33
Approaches to improve pain relief while minimizing opioid abuse liability. (20444651)
2010
34
Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. (20634006)
2010
35
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
36
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
37
Psychological comorbidities predicting prescription opioid abuse among patients in chronic pain presenting to the emergency department. (18266809)
2008
38
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
39
Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. (17449178)
2007
40
Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age. (18057194)
2007
41
Physicians advised on how to offer pain relief while preventing opioid abuse. (15353519)
2004
42
Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. (15542732)
2004
43
Prescription opioid abuse in patients presenting for methadone maintenance treatment. (14725960)
2004
44
Probable relationship between opioid abuse and heroin use. (12643356)
2003
45
Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. (12116270)
2002
46
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
47
A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. (11840318)
2002
48
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. (11591513)
2001
49
Opioid reward mechanisms: a key role in drug abuse? (9673788)
1998
50
Use of in vivo apparent pA2 analysis in assessment of opioid abuse liability. (1509522)
1992

Genetic Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Sources:
51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Opioid Abuse

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1dermorphin4410.0OPRM1, CCK
2loperamide44 11 2411.9OPRM1, CCK
3ondansetron44 49 11 2412.9OPRM1, CCK
4etorphine44 28 1111.8MAPK10, OPRM1
5naloxone44 49 28 1112.8OPRM1, CCK
6npff449.8CCK, NPFF
7deltorphin i449.8OPRM1, NPFF
8chelerythrine449.8MAPK10, OPRM1
9naltrindole44 2810.8OPRM1, NPFF
10pertussis449.7OPRM1, MAPK10
11amide449.6CCK, OPRM1
12gf 109203x44 5910.5MAPK10, OPRM1
13anisomycin44 1110.4MAPK10, OPRM1
14norepinephrine44 11 2411.4CCK, OPRM1, MAPK10
15histamine44 28 2411.4MAPK10, OPRM1, CCK
16acetylcholine44 49 28 11 2413.4CCK, OPRM1, MAPK10
17tetrapeptide449.4CCK, NPFF, OPRM1
18opiate449.3OPRM1, NPFF, CCK
19halothane44 28 1111.3OPRM1, GRIN3B
20glutamine449.3MAPK10, OPRM1, CCK
21pge2449.3CCK, OPRM1, MAPK10
22adenylate449.2MAPK10, OPRM1, CCK
23levodopa44 1110.2MAPK10, OPRM1
24nmda44 2810.0MAPK10, GRIN3B, OPRM1
25cyclic amp44 249.9MAPK10, OPRM1, NPFF
26morphine44 49 28 1111.8MAPK10, OPRM1, NPFF, CCK
27calcium44 49 11 2411.0CCK, NPFF, OPRM1, GRIN3B, MAPK10

GO Terms for genes affiliated with Opioid Abuse

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Sources:
16Gene Ontology
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Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.4NPFF, CCK
2elevation of cytosolic calcium ion concentrationGO:0072049.4OPRM1, NPFF
3regulation of sensory perception of painGO:0519309.3NPFF, CCK
4activation of MAPK activityGO:0001879.1FRS2, MAPK10

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opioid Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet