MCID: OPD001
MIFTS: 37

Opioid Abuse malady

Mental diseases category
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Summaries for Opioid Abuse

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Disease Ontology:8 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards based summary: Opioid Abuse is related to chronic pain and morphine dependence. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Pathway and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are no phenotypic analysis and nervous system.

Aliases & Classifications for Opioid Abuse

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Opioid Abuse, Aliases & Descriptions:

Name: Opioid Abuse 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:11206
SNOMED-CT57 5602001
ICD9CM27 305.5

Related Diseases for Opioid Abuse

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Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Symptoms for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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MalaCards organs/tissues related to Opioid Abuse:

32
Brain

Animal Models for Opioid Abuse or affiliated genes

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MGI Mouse Phenotypes related to Opioid Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1OPRM1, MAPK10, CCK
2MP:00036317.4OPRM1, GRIN3B, MAPK10, CCK, FRS2

Publications for Opioid Abuse

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Articles related to Opioid Abuse:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
2014
2
Opioid Abuse and Dependence during Pregnancy: Temporal Trends and Obstetrical Outcomes. (25405293)
2014
3
The opioid abuse and misuse epidemic: implications for pharmacists in hospitals and health systems. (25174015)
2014
4
New labels to curb opioid abuse. (25157060)
2014
5
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
6
Prescription Opioid Abuse and Tampering in the United States: Results of a Self-Report Survey. (24931057)
2014
7
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
8
Estimating the costs of opioid abuse and dependence from an employer perspective: a retrospective analysis using administrative claims data. (24919646)
2014
9
The prescription opioid abuse epidemic in rural America: A look at how it begins. (25162602)
2014
10
The ecology of prescription opioid abuse in the USA: geographic variation in patients' use of multiple prescribers ("doctor shopping"). (25111716)
2014
11
The economic burden of diagnosed opioid abuse among commercially insured individuals. (25141243)
2014
12
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
13
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
14
Perioperative pain therapy in opioid abuse. (23241915)
2013
15
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
16
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
17
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
18
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
19
Medications development for opioid abuse. (23125072)
2013
20
Tackling prescription opioid abuse. (23437581)
2013
21
Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. (22747546)
2012
22
Opioid abuse and pain management. (23062086)
2012
23
Prescription drug monitoring programs and other interventions to combat prescription opioid abuse. (23357954)
2012
24
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
25
Opioid abuse among nurse anesthetists and anesthesiologists. (22586881)
2012
26
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
27
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
28
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
29
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
30
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
31
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
32
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
33
Reducing opioid abuse and diversion. (21791685)
2011
34
Reducing opioid abuse and diversion. (21791684)
2011
35
The anesthetic implications of illicit opioid abuse. (21239906)
2011
36
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
37
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
38
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
39
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
40
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
41
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
42
Prescription opioid abuse among enrollees into methadone maintenance treatment. (17386981)
2007
43
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
44
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
45
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
46
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
47
Opioid abuse and cognitive performance. (15845327)
2005
48
Opioid abuse and brain gene expression. (15464044)
2004
49
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
50
Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. (16902682)
2001

Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Pathways related to Opioid Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MAPK10, CCK
2
Show member pathways
9.4NPFF, CCK
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4MAPK10, FRS2
4
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.4MAPK10, FRS2
5
Show member pathways
Development Flt3 signaling60
9.4FRS2, MAPK10
69.4FRS2, MAPK10
7
Show member pathways
Peptide GPCRs37
9.4NPFF, OPRM1
8
Show member pathways
8.7MAPK10, GRIN3B, OPRM1
9
Show member pathways
8.5NPFF, OPRM1, CCK, FRS2
10
Show member pathways
8.2NPFF, OPRM1, GRIN3B, CCK

Compounds for genes affiliated with Opioid Abuse

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Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dermorphin4410.0OPRM1, CCK
2loperamide44 24 1112.0OPRM1, CCK
3ondansetron50 44 24 1113.0OPRM1, CCK
4naloxone44 28 50 1112.9OPRM1, CCK
5amphetamine44 50 1111.9CCK, OPRM1
6etorphine44 28 1111.9OPRM1, MAPK10
7amide449.9OPRM1, CCK
8chelerythrine449.8OPRM1, MAPK10
9npff449.8CCK, NPFF
10pertussis449.8MAPK10, OPRM1
11cocaine44 1110.8OPRM1, CCK
12deltorphin i449.8NPFF, OPRM1
13naltrindole44 2810.8NPFF, OPRM1
14anisomycin44 1110.8OPRM1, MAPK10
15levodopa44 1110.7MAPK10, OPRM1
165-hydroxytryptamine449.7CCK, OPRM1
17ibmx44 61 2811.7CCK, MAPK10
18gf 109203x44 6110.7OPRM1, MAPK10
19carbachol44 28 1111.7MAPK10, CCK
20carbon449.7OPRM1, CCK
21phenylalanine449.5CCK, FRS2
22halothane44 50 28 1112.5GRIN3B, OPRM1
23nicotine44 28 50 1112.5OPRM1, MAPK10
24norepinephrine44 24 1111.5CCK, MAPK10, OPRM1
25histamine44 28 2411.5OPRM1, MAPK10, CCK
26thapsigargin44 6110.4CCK, MAPK10
27acetylcholine44 50 28 24 1113.4CCK, MAPK10, OPRM1
28glutamine449.4CCK, MAPK10, OPRM1
29pge2449.4OPRM1, MAPK10, CCK
30tetrapeptide449.4CCK, OPRM1, NPFF
31opiate449.4CCK, OPRM1, NPFF
32adenylate449.4OPRM1, MAPK10, CCK
335fluorouracil449.2MAPK10, CCK
34cyclic amp44 2410.2MAPK10, OPRM1, NPFF
35nmda44 2810.1MAPK10, GRIN3B, OPRM1
36morphine44 50 28 1111.9NPFF, OPRM1, MAPK10, CCK
37calcium44 50 24 1111.0CCK, MAPK10, GRIN3B, OPRM1, NPFF

GO Terms for genes affiliated with Opioid Abuse

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Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK
2dendriteGO:0304258.3NPFF, GRIN3B, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.6NPFF, CCK
2regulation of sensory perception of painGO:0519309.5NPFF, CCK
3activation of MAPK activityGO:0001879.4MAPK10, FRS2
4Fc-epsilon receptor signaling pathwayGO:0380959.4MAPK10, FRS2
5neuropeptide signaling pathwayGO:0072189.3OPRM1, NPFF
6positive regulation of cytosolic calcium ion concentrationGO:0072049.1NPFF, OPRM1

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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Sources for Opioid Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet