MCID: OPD001
MIFTS: 32

Opioid Abuse malady

Summaries for Opioid Abuse

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards: Opioid Abuse is related to chronic pain and cocaine abuse. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Family Ligands and Receptor Interactions and Development FGF-family signaling. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype nervous system.

Aliases & Classifications for Opioid Abuse

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

opioid abuse 8 10 45 61


External Ids:

Disease Ontology8 DOID:11206
SNOMED-CT57 5602001
ICD9CM27 305.5

Related Diseases for Opioid Abuse

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Opioid Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1chronic pain10.6
2cocaine abuse10.2
3alcohol abuse10.1
4pain disorder10.1
5cannabis abuse10.1
6substance abuse10.1
7oral cancer10.1
8morphine dependence10.0CCK
9neuroblastoma10.0OPRM1
10colon cancer10.0MAPK10
11ileus10.0OPRM1
12neuroepithelioma10.0CCK, MAPK10
13withdrawal disorder10.0OPRM1, NPFF
14opiate dependence10.0OPRM1, NPFF
15galactosemia10.0OPRM1, CCK
16psychotic disorder10.0CCK, OPRM1
17insulin resistance10.0MAPK10, OPRM1
18pain agnosia10.0OPRM1, NPFF, CCK
19constipation10.0OPRM1, CCK

Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Clinical Features for Opioid Abuse

Drugs & Therapeutics for Opioid Abuse

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Opioid Abuse

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Search CenterWatch for Opioid Abuse

Genetic Tests for Opioid Abuse

Anatomical Context for Opioid Abuse

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Opioid Abuse:

33
Brain

Animal Models for Opioid Abuse or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Opioid Abuse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7FRS2, MAPK10, GRIN3B, OPRM1, CCK

Publications for Opioid Abuse

Sources:
51PubMed
See all sources

Articles related to Opioid Abuse:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
2
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
3
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
4
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
5
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
6
Medications development for opioid abuse. (23125072)
2013
7
The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals with Chronic Non-cancer Pain: The Role of Opioid Prescription. (24281273)
2013
8
Prescription opioid abuse in the UK. (23594290)
2013
9
The Prevalence of Diagnosed Opioid Abuse in Commercial and Medicare Managed Care Populations. (24289539)
2013
10
Understanding the etiology of prescription opioid abuse: implications for prevention and treatment. (23656723)
2013
11
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
12
Adolescent opioid abuse. (22945324)
2012
13
Prescription opioid abuse update for the clinical nurse specialist. (22146269)
2012
14
Clinical strategies for the primary health care professional to minimize prescription opioid abuse. (22691907)
2012
15
Prevention of opioid abuse in chronic non-cancer pain: an algorithmic, evidence based approach. (22786456)
2012
16
Clinical differences between opioid abuse classes ameliorated after 1 year of buprenorphine-medication assisted treatment. (22540432)
2012
17
Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse. (22778118)
2012
18
Characterization of prescription opioid abuse in the United States: focus on route of administration. (23675595)
2012
19
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
20
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
21
Reducing opioid abuse and diversion. (21791685)
2011
22
Typologies of prescription opioid use in a large sample of adults assessed for substance abuse treatment. (22087270)
2011
23
Age differences in heroin and prescription opioid abuse among enrolees into opioid treatment programs. (21635762)
2011
24
Comparison of early maladaptive schemas and parenting origins in patients with opioid abuse and non-abusers. (22952522)
2011
25
Illustration of a statistical process control approach to regional prescription opioid abuse surveillance. (21769055)
2011
26
Can prescription drug monitoring programs help limit opioid abuse? (22110107)
2011
27
Prevention of prescription opioid abuse: the role of the dentist. (21719802)
2011
28
Reducing opioid abuse and diversion. (21791683)
2011
29
Herbal medicines: perfect garb for opioid abuse? A case series from India. (21314761)
2011
30
The locus coeruleus: A key nucleus where stress and opioids intersect to mediate vulnerability to opiate abuse. (19765557)
2010
31
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
32
Variation among state-level approaches to addressing alcohol abuse in opioid treatment programs. (20418050)
2010
33
Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies. (20665209)
2010
34
Commentary on Boscarino et al. (2010): Understanding the spectrum of opioid abuse, misuse and harms among chronic opioid therapy patients. (20860077)
2010
35
The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. (20352414)
2010
36
Approaches to improve pain relief while minimizing opioid abuse liability. (20444651)
2010
37
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
38
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
39
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
40
Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. (17449178)
2007
41
Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age. (18057194)
2007
42
Opioid abuse and brain gene expression. (15464044)
2004
43
Physicians advised on how to offer pain relief while preventing opioid abuse. (15353519)
2004
44
Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. (15542732)
2004
45
Prescription opioid abuse in patients presenting for methadone maintenance treatment. (14725960)
2004
46
A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. (11840318)
2002
47
Opioid reward mechanisms: a key role in drug abuse? (9673788)
1998
48
Pharmacotherapy for opioid and cocaine abuse. (9222260)
1997
49
Cocaine effects on dopamine and opioid peptide neural systems: implications for human cocaine abuse. (8809855)
1996
50
Use of in vivo apparent pA2 analysis in assessment of opioid abuse liability. (1509522)
1992

Genetic Variations for Opioid Abuse

Expression for genes affiliated with Opioid Abuse

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

Sources:
52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Opioid Abuse

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1dermorphin4510.0OPRM1, CCK
2loperamide45 11 2411.9OPRM1, CCK
3ondansetron45 50 11 2412.9OPRM1, CCK
4etorphine45 29 1111.8MAPK10, OPRM1
5naloxone45 50 29 1112.8OPRM1, CCK
6npff459.8CCK, NPFF
7deltorphin i459.8OPRM1, NPFF
8chelerythrine459.8MAPK10, OPRM1
9naltrindole45 2910.8OPRM1, NPFF
10pertussis459.7OPRM1, MAPK10
11amide459.6CCK, OPRM1
12gf 109203x45 6010.5MAPK10, OPRM1
13anisomycin45 1110.4MAPK10, OPRM1
14norepinephrine45 11 2411.4CCK, OPRM1, MAPK10
15histamine45 29 2411.4MAPK10, OPRM1, CCK
16acetylcholine45 50 29 11 2413.4CCK, OPRM1, MAPK10
17tetrapeptide459.4CCK, NPFF, OPRM1
18opiate459.3OPRM1, NPFF, CCK
19halothane45 29 1111.3OPRM1, GRIN3B
20glutamine459.3MAPK10, OPRM1, CCK
21pge2459.3CCK, OPRM1, MAPK10
22adenylate459.2MAPK10, OPRM1, CCK
23levodopa45 1110.2MAPK10, OPRM1
24nmda45 2910.0MAPK10, GRIN3B, OPRM1
25cyclic amp45 249.9MAPK10, OPRM1, NPFF
26morphine45 50 29 1111.8MAPK10, OPRM1, NPFF, CCK
27calcium45 50 11 2411.0CCK, NPFF, OPRM1, GRIN3B, MAPK10

GO Terms for genes affiliated with Opioid Abuse

Sources:
16Gene Ontology
See all sources

Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.4NPFF, CCK
2elevation of cytosolic calcium ion concentrationGO:0072049.4OPRM1, NPFF
3regulation of sensory perception of painGO:0519309.3NPFF, CCK
4activation of MAPK activityGO:0001879.1FRS2, MAPK10

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opioid Abuse

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet