Aliases & Classifications for Opioid Abuse

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Opioid Abuse, Aliases & Descriptions:

Name: Opioid Abuse 9 11 43 60


External Ids:

Disease Ontology9 DOID:11206
SNOMED-CT55 5602001
ICD9CM27 305.5

Summaries for Opioid Abuse

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Disease Ontology:9 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards based summary: Opioid Abuse is related to hiv-1 and chronic pain. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Pathway and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related mouse phenotypes are no phenotypic analysis and nervous system.

Related Diseases for Opioid Abuse

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Graphical network of the top 20 diseases related to Opioid Abuse:



Diseases related to opioid abuse

Symptoms for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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MalaCards organs/tissues related to Opioid Abuse:

31
Brain, Heart

Animal Models for Opioid Abuse or affiliated genes

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MGI Mouse Phenotypes related to Opioid Abuse:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1OPRM1, MAPK10, CCK
2MP:00036317.4OPRM1, GRIN3B, MAPK10, CCK, FRS2

Publications for Opioid Abuse

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Articles related to Opioid Abuse:

(show top 50)    (show all 148)
idTitleAuthorsYear
1
The Fentanyl Patch Boil-Up - A Novel Method of Opioid Abuse. (25892448)
2015
2
Preventing prescription opioid abuse--reply. (25756451)
2015
3
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
2014
4
Opioid Abuse and Dependence during Pregnancy: Temporal Trends and Obstetrical Outcomes. (25405293)
2014
5
The opioid abuse and misuse epidemic: implications for pharmacists in hospitals and health systems. (25174015)
2014
6
New labels to curb opioid abuse. (25157060)
2014
7
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
8
Prescription Opioid Abuse and Tampering in the United States: Results of a Self-Report Survey. (24931057)
2014
9
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
10
Estimating the costs of opioid abuse and dependence from an employer perspective: a retrospective analysis using administrative claims data. (24919646)
2014
11
The prescription opioid abuse epidemic in rural America: A look at how it begins. (25162602)
2014
12
The ecology of prescription opioid abuse in the USA: geographic variation in patients' use of multiple prescribers ("doctor shopping"). (25111716)
2014
13
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
14
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
15
Perioperative pain therapy in opioid abuse. (23241915)
2013
16
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
17
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
18
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
19
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
20
Medications development for opioid abuse. (23125072)
2013
21
Tackling prescription opioid abuse. (23437581)
2013
22
Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. (22747546)
2012
23
Opioid abuse and pain management. (23062086)
2012
24
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
25
Opioid abuse among nurse anesthetists and anesthesiologists. (22586881)
2012
26
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
27
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
28
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
29
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
30
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
31
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
32
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
33
Reducing opioid abuse and diversion. (21791685)
2011
34
Reducing opioid abuse and diversion. (21791684)
2011
35
The anesthetic implications of illicit opioid abuse. (21239906)
2011
36
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
37
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
38
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
39
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
40
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
41
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
42
Prescription opioid abuse among enrollees into methadone maintenance treatment. (17386981)
2007
43
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
44
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
45
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
46
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
47
Opioid abuse and cognitive performance. (15845327)
2005
48
Opioid abuse and brain gene expression. (15464044)
2004
49
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
50
Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. (16902682)
2001

Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Pathways related to Opioid Abuse according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CCK, MAPK10
2
Show member pathways
9.4CCK, NPFF
3
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.4MAPK10, FRS2
4
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.4FRS2, MAPK10
5
Show member pathways
Development Flt3 signaling58
9.4FRS2, MAPK10
69.4MAPK10, FRS2
7
Show member pathways
8.7GRIN3B, MAPK10, OPRM1
8
Show member pathways
8.5OPRM1, CCK, FRS2, NPFF
9
Show member pathways
8.2NPFF, GRIN3B, CCK, OPRM1

Compounds for genes affiliated with Opioid Abuse

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Compounds related to Opioid Abuse according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dermorphin4310.0OPRM1, CCK
2loperamide43 24 1212.0OPRM1, CCK
3ondansetron49 43 24 1213.0OPRM1, CCK
4naloxone43 28 49 1212.9OPRM1, CCK
5amphetamine43 49 1211.9CCK, OPRM1
6etorphine43 28 1211.9OPRM1, MAPK10
7amide439.9OPRM1, CCK
8chelerythrine439.8OPRM1, MAPK10
9npff439.8CCK, NPFF
10pertussis439.8MAPK10, OPRM1
11cocaine43 1210.8OPRM1, CCK
12deltorphin i439.8NPFF, OPRM1
13naltrindole43 2810.8NPFF, OPRM1
14anisomycin43 1210.8OPRM1, MAPK10
15levodopa43 1210.7MAPK10, OPRM1
165-hydroxytryptamine439.7CCK, OPRM1
17ibmx43 59 2811.7CCK, MAPK10
18gf 109203x43 5910.7OPRM1, MAPK10
19carbachol43 28 1211.7MAPK10, CCK
20carbon439.7OPRM1, CCK
21phenylalanine439.5CCK, FRS2
22halothane43 49 28 1212.5GRIN3B, OPRM1
23nicotine43 28 49 1212.5OPRM1, MAPK10
24norepinephrine43 24 1211.5CCK, MAPK10, OPRM1
25histamine43 28 2411.5OPRM1, MAPK10, CCK
26thapsigargin43 5910.4CCK, MAPK10
27acetylcholine43 49 28 24 1213.4CCK, MAPK10, OPRM1
28glutamine439.4CCK, MAPK10, OPRM1
29pge2439.4OPRM1, MAPK10, CCK
30tetrapeptide439.4CCK, OPRM1, NPFF
31opiate439.4CCK, OPRM1, NPFF
32adenylate439.4OPRM1, MAPK10, CCK
335fluorouracil439.2MAPK10, CCK
34cyclic amp43 2410.2MAPK10, OPRM1, NPFF
35nmda43 2810.1MAPK10, GRIN3B, OPRM1
36morphine43 49 28 1211.9NPFF, OPRM1, MAPK10, CCK
37calcium43 49 24 1211.0CCK, MAPK10, GRIN3B, OPRM1, NPFF

GO Terms for genes affiliated with Opioid Abuse

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Cellular components related to Opioid Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:00432049.4NPFF, CCK
2dendriteGO:00304258.3NPFF, GRIN3B, CCK

Biological processes related to Opioid Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:00320999.6NPFF, CCK
2regulation of sensory perception of painGO:00519309.5NPFF, CCK
3activation of MAPK activityGO:00001879.4MAPK10, FRS2
4Fc-epsilon receptor signaling pathwayGO:00380959.4MAPK10, FRS2
5neuropeptide signaling pathwayGO:00072189.3OPRM1, NPFF
6positive regulation of cytosolic calcium ion concentrationGO:00072049.1NPFF, OPRM1

Molecular functions related to Opioid Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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Sources for Opioid Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet