MCID: OPD001
MIFTS: 33

Opioid Abuse malady

Summaries for Opioid Abuse

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Sources:
8Disease Ontology, 32MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards: Opioid Abuse is related to cocaine abuse and alcohol abuse. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Family Ligands and Receptor Interactions and Development FGF-family signaling. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype nervous system.

Aliases & Classifications for Opioid Abuse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

opioid abuse 8 10 44 60


External Ids:

Disease Ontology8 DOID:11206
SNOMED-CT56 5602001
ICD9CM27 305.5

Related Diseases for Opioid Abuse

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Opioid Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1cocaine abuse10.2
2alcohol abuse10.1
3cerebritis10.1
4pain disorder10.1
5cannabis abuse10.1
6substance abuse10.1
7morphine dependence10.0CCK
8neuroblastoma10.0OPRM1
9colon cancer10.0MAPK10
10ileus10.0OPRM1
11neuroepithelioma10.0CCK, MAPK10
12withdrawal disorder10.0OPRM1, NPFF
13opiate dependence10.0OPRM1, NPFF
14galactosemia10.0OPRM1, CCK
15psychotic disorder10.0CCK, OPRM1
16insulin resistance10.0MAPK10, OPRM1
17pain agnosia10.0OPRM1, NPFF, CCK
18constipation10.0OPRM1, CCK

Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Clinical Features for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opioid Abuse

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Search CenterWatch for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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Sources:
32MalaCards
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MalaCards organs/tissues related to Opioid Abuse:

32
Brain

Animal Models for Opioid Abuse or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Opioid Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7FRS2, MAPK10, GRIN3B, OPRM1, CCK

Publications for Opioid Abuse

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Sources:
50PubMed
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Articles related to Opioid Abuse:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
2
Overdose prevention in injecting opioid users: The role of substance abuse treatment and training programs. (24418018)
2014
3
Concurrent substance abuse is associated with sexual risk behavior among adults seeking treatment for prescription opioid dependence. (24313238)
2014
4
Perioperative pain therapy in opioid abuse. (23241915)
2013
5
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
6
Tackling prescription opioid abuse. (23437581)
2013
7
Changes in Prevalence of Prescription Opioid Abuse after Introduction of an Abuse-Deterrent Opioid Formulation. (24330279)
2013
8
Opioid abuse. (23509225)
2013
9
Opioid abuse and pain management. (23062086)
2012
10
Prescription drug monitoring programs and other interventions to combat prescription opioid abuse. (23357954)
2012
11
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
12
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
13
The social production of substance abuse and HIV/HCV risk: an exploratory study of opioid-using immigrants from the former Soviet Union living in New York City. (22239997)
2012
14
Do prescription monitoring programs impact state trends in opioid abuse/misuse? (22299725)
2012
15
Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. (22459870)
2012
16
Patterns of prescription opioid abuse and comorbidity in an aging treatment population. (21831562)
2012
17
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
18
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
19
The anesthetic implications of illicit opioid abuse. (21239906)
2011
20
Parental prescription opioid abuse and the impact on children. (21851201)
2011
21
Dexmedetomidine infusion to facilitate opioid detoxification and withdrawal in a patient with chronic opioid abuse. (22346054)
2011
22
Incomplete financial disclosures in a letter on reducing opioid abuse and diversion. (21934037)
2011
23
Incomplete financial disclosures in a letter on reducing opioid abuse and diversion. (21934038)
2011
24
Prescription opioid abuse: what is the real problem and how do we fix it? (22084451)
2011
25
Prescription opioid abuse, pain and addiction: clinical issues and implications. (21545561)
2011
26
Costs of opioid abuse and misuse determined from a Medicaid database. (20345194)
2010
27
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
28
Endogenous opioids and addiction to alcohol and other drugs of abuse. (19747123)
2009
29
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
30
Analytic models to identify patients at risk for prescription opioid abuse. (20001171)
2009
31
Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression. (18184800)
2008
32
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
33
Trends in nonheroin opioid abuse admissions: 1992-2004. (17957981)
2007
34
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
35
Prescription opioid abuse among drug-involved street-based sex workers. (17319260)
2006
36
Wanted: a public health approach to prescription opioid abuse and diversion. (16862603)
2006
37
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. (16682632)
2006
38
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
39
JAMA patient page. Opioid abuse. (15367561)
2004
40
Patterns of illicit drug use and opioid abuse in patients with chronic pain at initial evaluation: a prospective, observational study. (16858484)
2004
41
Clinical implications and methodological challenges in the study of the neuropsychological correlates of cannabis, stimulant, and opioid abuse. (15260137)
2004
42
Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse. (12570846)
2003
43
No data to show link between opioid abuse and heroin use. (14677660)
2003
44
College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement. (12633908)
2003
45
Changes in mu opioid receptors and rheological properties of erythrocytes among opioid abusers. (12006216)
2002
46
Opioid abuse in interventional pain medicine. (16896363)
2002
47
Opioid receptor polymorphisms and opioid abuse. (11972443)
2002
48
Recurrent femoral pseudoaneurysm following intravenous opioid abuse: a case report. (11294329)
2000
49
Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse. (10812979)
2000
50
Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures. (8726752)
1996

Genetic Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Sources:
51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Opioid Abuse

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1dermorphin4410.0OPRM1, CCK
2loperamide44 11 2411.9OPRM1, CCK
3ondansetron44 49 11 2412.9OPRM1, CCK
4etorphine44 28 1111.8MAPK10, OPRM1
5naloxone44 49 28 1112.8OPRM1, CCK
6npff449.8CCK, NPFF
7deltorphin i449.8OPRM1, NPFF
8chelerythrine449.8MAPK10, OPRM1
9naltrindole44 2810.8OPRM1, NPFF
10pertussis449.7OPRM1, MAPK10
11amide449.6CCK, OPRM1
12gf 109203x44 5910.5MAPK10, OPRM1
13anisomycin44 1110.4MAPK10, OPRM1
14norepinephrine44 11 2411.4CCK, OPRM1, MAPK10
15histamine44 28 2411.4MAPK10, OPRM1, CCK
16acetylcholine44 49 28 11 2413.4CCK, OPRM1, MAPK10
17tetrapeptide449.4CCK, NPFF, OPRM1
18opiate449.3OPRM1, NPFF, CCK
19halothane44 28 1111.3OPRM1, GRIN3B
20glutamine449.3MAPK10, OPRM1, CCK
21pge2449.3CCK, OPRM1, MAPK10
22adenylate449.2MAPK10, OPRM1, CCK
23levodopa44 1110.2MAPK10, OPRM1
24nmda44 2810.0MAPK10, GRIN3B, OPRM1
25cyclic amp44 249.9MAPK10, OPRM1, NPFF
26morphine44 49 28 1111.8MAPK10, OPRM1, NPFF, CCK
27calcium44 49 11 2411.0CCK, NPFF, OPRM1, GRIN3B, MAPK10

GO Terms for genes affiliated with Opioid Abuse

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Sources:
16Gene Ontology
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Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.4NPFF, CCK
2elevation of cytosolic calcium ion concentrationGO:0072049.4OPRM1, NPFF
3regulation of sensory perception of painGO:0519309.3NPFF, CCK
4activation of MAPK activityGO:0001879.1FRS2, MAPK10

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opioid Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet