MCID: OPD001
MIFTS: 37

Opioid Abuse malady

Mental diseases category

Summaries for Opioid Abuse

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Sources:
9Disease Ontology, 34MalaCards
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Disease Ontology:9 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards: Opioid Abuse is related to chronic pain and cerebritis. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Pathway and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are no phenotypic analysis and nervous system.

Aliases & Classifications for Opioid Abuse

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

opioid abuse 9 11 46 63


External Ids:

Disease Ontology9 DOID:11206
SNOMED-CT59 5602001
ICD9CM28 305.5

Related Diseases for Opioid Abuse

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Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Symptoms for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Opioid Abuse

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Search CenterWatch for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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Sources:
34MalaCards
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MalaCards organs/tissues related to Opioid Abuse:

34
Brain

Animal Models for Opioid Abuse or affiliated genes

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Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Opioid Abuse:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1OPRM1, MAPK10, CCK
2MP:00036317.4OPRM1, GRIN3B, MAPK10, CCK, FRS2

Publications for Opioid Abuse

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Sources:
53PubMed
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Articles related to Opioid Abuse:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
2
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
3
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
4
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
5
Perioperative pain therapy in opioid abuse. (23241915)
2013
6
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
7
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
8
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
9
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
10
Medications development for opioid abuse. (23125072)
2013
11
Tackling prescription opioid abuse. (23437581)
2013
12
Prevalence and cost of diagnosed opioid abuse in a privately insured population in the United States. (23771567)
2013
13
Estimates of charges associated with emergency department and hospital inpatient care for opioid abuse-related events. (23879214)
2013
14
The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals with Chronic Non-cancer Pain: The Role of Opioid Prescription. (24281273)
2013
15
Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. (22747546)
2012
16
Opioid abuse and pain management. (23062086)
2012
17
Prescription drug monitoring programs and other interventions to combat prescription opioid abuse. (23357954)
2012
18
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
19
Opioid abuse among nurse anesthetists and anesthesiologists. (22586881)
2012
20
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
21
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
22
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
23
Adolescent opioid abuse. (22945324)
2012
24
Prescription opioid abuse update for the clinical nurse specialist. (22146269)
2012
25
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
26
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
27
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
28
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
29
Reducing opioid abuse and diversion. (21791685)
2011
30
Reducing opioid abuse and diversion. (21791684)
2011
31
The anesthetic implications of illicit opioid abuse. (21239906)
2011
32
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
33
Costs of opioid abuse and misuse determined from a Medicaid database. (20345194)
2010
34
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
35
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
36
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
37
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
38
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
39
Prescription opioid abuse among enrollees into methadone maintenance treatment. (17386981)
2007
40
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
41
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
42
Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. (17449178)
2007
43
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
44
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
45
Opioid abuse and cognitive performance. (15845327)
2005
46
Opioid abuse and brain gene expression. (15464044)
2004
47
Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse. (12570846)
2003
48
Probable relationship between opioid abuse and heroin use. (12643356)
2003
49
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
50
Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. (16902682)
2001

Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Sources:
51PathCards, 62Tocris Bioscience, 54QIAGEN, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 13EMD Millipore
See all sources

Pathways related to Opioid Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MAPK10, CCK
2
Show member pathways
9.4NPFF, CCK
3
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.4MAPK10, FRS2
4
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.4MAPK10, FRS2
5
Show member pathways
Development Flt3 signaling61
9.4FRS2, MAPK10
69.4FRS2, MAPK10
7
Show member pathways
Peptide GPCRs39
9.4NPFF, OPRM1
8
Show member pathways
8.7MAPK10, GRIN3B, OPRM1
9
Show member pathways
8.5NPFF, OPRM1, CCK, FRS2
10
Show member pathways
8.2NPFF, OPRM1, GRIN3B, CCK

Compounds for genes affiliated with Opioid Abuse

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dermorphin4610.0OPRM1, CCK
2loperamide46 25 1212.0OPRM1, CCK
3ondansetron52 46 25 1213.0OPRM1, CCK
4naloxone46 30 52 1212.9OPRM1, CCK
5amphetamine46 52 1211.9CCK, OPRM1
6etorphine46 30 1211.9OPRM1, MAPK10
7amide469.9OPRM1, CCK
8chelerythrine469.8OPRM1, MAPK10
9npff469.8CCK, NPFF
10pertussis469.8MAPK10, OPRM1
11cocaine46 1210.8OPRM1, CCK
12deltorphin i469.8NPFF, OPRM1
13naltrindole46 3010.8NPFF, OPRM1
14anisomycin46 1210.8OPRM1, MAPK10
15levodopa46 1210.7MAPK10, OPRM1
165-hydroxytryptamine469.7CCK, OPRM1
17ibmx46 62 3011.7CCK, MAPK10
18gf 109203x46 6210.7OPRM1, MAPK10
19carbachol46 30 1211.7MAPK10, CCK
20carbon469.7OPRM1, CCK
21phenylalanine469.5CCK, FRS2
22halothane46 52 30 1212.5GRIN3B, OPRM1
23nicotine46 30 52 1212.5OPRM1, MAPK10
24norepinephrine46 25 1211.5CCK, MAPK10, OPRM1
25histamine46 30 2511.5OPRM1, MAPK10, CCK
26thapsigargin46 6210.4CCK, MAPK10
27acetylcholine46 52 30 25 1213.4CCK, MAPK10, OPRM1
28glutamine469.4CCK, MAPK10, OPRM1
29pge2469.4OPRM1, MAPK10, CCK
30tetrapeptide469.4CCK, OPRM1, NPFF
31opiate469.4CCK, OPRM1, NPFF
32adenylate469.4OPRM1, MAPK10, CCK
335fluorouracil469.2MAPK10, CCK
34cyclic amp46 2510.2MAPK10, OPRM1, NPFF
35nmda46 3010.1MAPK10, GRIN3B, OPRM1
36morphine46 52 30 1211.9NPFF, OPRM1, MAPK10, CCK
37calcium46 52 25 1211.0CCK, MAPK10, GRIN3B, OPRM1, NPFF

GO Terms for genes affiliated with Opioid Abuse

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Sources:
17Gene Ontology
See all sources

Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK
2dendriteGO:0304258.3NPFF, GRIN3B, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.6NPFF, CCK
2regulation of sensory perception of painGO:0519309.5NPFF, CCK
3activation of MAPK activityGO:0001879.4MAPK10, FRS2
4Fc-epsilon receptor signaling pathwayGO:0380959.4MAPK10, FRS2
5neuropeptide signaling pathwayGO:0072189.3OPRM1, NPFF
6positive regulation of cytosolic calcium ion concentrationGO:0072049.1NPFF, OPRM1

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opioid Abuse

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet