MCID: OPD001
MIFTS: 37

Opioid Abuse malady

Mental diseases category
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Summaries for Opioid Abuse

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Sources:
8Disease Ontology, 33MalaCards
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Fully expand this MalaCard
Disease Ontology:8 A substance abuse that involves the recurring use of opioid drugs despite negative consequences.

MalaCards: Opioid Abuse is related to chronic pain and cerebritis. An important gene associated with Opioid Abuse is CCK (cholecystokinin), and among its related pathways are VEGF Pathway and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds dermorphin and loperamide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are no phenotypic analysis and nervous system.

Aliases & Classifications for Opioid Abuse

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

opioid abuse 8 10 45 62


External Ids:

Disease Ontology8 DOID:11206
SNOMED-CT58 5602001
ICD9CM27 305.5

Related Diseases for Opioid Abuse

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Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Opioid Abuse:



Diseases related to opioid abuse

Symptoms for Opioid Abuse

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Drugs & Therapeutics for Opioid Abuse

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Opioid Abuse

Search NIH Clinical Center for Opioid Abuse

Genetic Tests for Opioid Abuse

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Anatomical Context for Opioid Abuse

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Sources:
33MalaCards
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MalaCards organs/tissues related to Opioid Abuse:

33
Brain

Animal Models for Opioid Abuse or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Opioid Abuse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1OPRM1, MAPK10, CCK
2MP:00036317.4OPRM1, GRIN3B, MAPK10, CCK, FRS2

Publications for Opioid Abuse

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Sources:
52PubMed
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Articles related to Opioid Abuse:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pharmacists' role in addressing opioid abuse, addiction, and diversion. (24257743)
2014
2
Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits. (24130046)
2014
3
Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum. (24353438)
2013
4
Opioid abuse puts physicians between a rock and a hard place but resources can help them lead the debate on how to rein it in. (24354119)
2013
5
Perioperative pain therapy in opioid abuse. (23241915)
2013
6
Cost Drivers of Prescription Opioid Abuse in Commercial and Medicare Populations. (24268019)
2013
7
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
8
Prescription opioid abuse: challenges and opportunities for payers. (23725361)
2013
9
Doctor shopping reveals geographical variations in opioid abuse. (23340537)
2013
10
Medications development for opioid abuse. (23125072)
2013
11
Tackling prescription opioid abuse. (23437581)
2013
12
Prevalence and cost of diagnosed opioid abuse in a privately insured population in the United States. (23771567)
2013
13
Estimates of charges associated with emergency department and hospital inpatient care for opioid abuse-related events. (23879214)
2013
14
The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals with Chronic Non-cancer Pain: The Role of Opioid Prescription. (24281273)
2013
15
Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. (22747546)
2012
16
Opioid abuse and pain management. (23062086)
2012
17
Prescription drug monitoring programs and other interventions to combat prescription opioid abuse. (23357954)
2012
18
Opium and opioid abuse in orthopedic inpatients: a cross sectional study in Urmia University of Medical Sciences. (22267382)
2012
19
Opioid abuse among nurse anesthetists and anesthesiologists. (22586881)
2012
20
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. (22998781)
2012
21
Temporal and geographic patterns in opioid abuse in Texas. (22540431)
2012
22
Prescription opioid abuse, chronic pain, and primary care: a Co-occurring Disorders Clinic in the chronic disease model. (22980449)
2012
23
Adolescent opioid abuse. (22945324)
2012
24
Prescription opioid abuse update for the clinical nurse specialist. (22146269)
2012
25
Societal costs of prescription opioid abuse, dependence, and misuse in the United States. (21392250)
2011
26
Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain. (22048003)
2011
27
REMS; red tape, or a remedy for opioid abuse? (22442761)
2011
28
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care. (21785486)
2011
29
Reducing opioid abuse and diversion. (21791685)
2011
30
Reducing opioid abuse and diversion. (21791684)
2011
31
The anesthetic implications of illicit opioid abuse. (21239906)
2011
32
Intranasal self-administration of remifentanil as the foray into opioid abuse by an anesthesia resident. (19917624)
2010
33
Costs of opioid abuse and misuse determined from a Medicaid database. (20345194)
2010
34
The underrecognized toll of prescription opioid abuse on young children. (18774623)
2009
35
Opioid abuse amongst anaesthetists: a system to detect personal usage. (19400491)
2009
36
Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment. (19416440)
2009
37
Are some physicians unwitting enablers of prescription opioid abuse? (19507802)
2009
38
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. (18606504)
2008
39
Prescription opioid abuse among enrollees into methadone maintenance treatment. (17386981)
2007
40
Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. (17520988)
2007
41
Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. (17710013)
2007
42
Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. (17449178)
2007
43
Buprenorphine for heroin addicts: the issue of illicit opioid abuse during maintenance. (17062539)
2006
44
Direct costs of opioid abuse in an insured population in the United States. (15998164)
2005
45
Opioid abuse and cognitive performance. (15845327)
2005
46
Opioid abuse and brain gene expression. (15464044)
2004
47
Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse. (12570846)
2003
48
Probable relationship between opioid abuse and heroin use. (12643356)
2003
49
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
50
Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. (16902682)
2001

Variations for Opioid Abuse

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Expression for genes affiliated with Opioid Abuse

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Opioid Abuse

Search GEO for disease gene expression data for Opioid Abuse.

Pathways for genes affiliated with Opioid Abuse

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Sources:
50PathCards, 61Tocris Bioscience, 53QIAGEN, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
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Pathways related to Opioid Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MAPK10, CCK
2
Show member pathways
9.4NPFF, CCK
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4MAPK10, FRS2
4
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.4MAPK10, FRS2
5
Show member pathways
Development Flt3 signaling60
9.4FRS2, MAPK10
69.4FRS2, MAPK10
7
Show member pathways
Peptide GPCRs38
9.4NPFF, OPRM1
8
Show member pathways
8.7MAPK10, GRIN3B, OPRM1
9
Show member pathways
8.5NPFF, OPRM1, CCK, FRS2
10
Show member pathways
8.2NPFF, OPRM1, GRIN3B, CCK

Compounds for genes affiliated with Opioid Abuse

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Opioid Abuse according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dermorphin4510.0OPRM1, CCK
2loperamide45 24 1112.0OPRM1, CCK
3ondansetron51 45 24 1113.0OPRM1, CCK
4naloxone45 29 51 1112.9OPRM1, CCK
5amphetamine45 51 1111.9CCK, OPRM1
6etorphine45 29 1111.9OPRM1, MAPK10
7amide459.9OPRM1, CCK
8chelerythrine459.8OPRM1, MAPK10
9npff459.8CCK, NPFF
10pertussis459.8MAPK10, OPRM1
11cocaine45 1110.8OPRM1, CCK
12deltorphin i459.8NPFF, OPRM1
13naltrindole45 2910.8NPFF, OPRM1
14anisomycin45 1110.8OPRM1, MAPK10
15levodopa45 1110.7MAPK10, OPRM1
165-hydroxytryptamine459.7CCK, OPRM1
17ibmx45 61 2911.7CCK, MAPK10
18gf 109203x45 6110.7OPRM1, MAPK10
19carbachol45 29 1111.7MAPK10, CCK
20carbon459.7OPRM1, CCK
21phenylalanine459.5CCK, FRS2
22halothane45 51 29 1112.5GRIN3B, OPRM1
23nicotine45 29 51 1112.5OPRM1, MAPK10
24norepinephrine45 24 1111.5CCK, MAPK10, OPRM1
25histamine45 29 2411.5OPRM1, MAPK10, CCK
26thapsigargin45 6110.4CCK, MAPK10
27acetylcholine45 51 29 24 1113.4CCK, MAPK10, OPRM1
28glutamine459.4CCK, MAPK10, OPRM1
29pge2459.4OPRM1, MAPK10, CCK
30tetrapeptide459.4CCK, OPRM1, NPFF
31opiate459.4CCK, OPRM1, NPFF
32adenylate459.4OPRM1, MAPK10, CCK
335fluorouracil459.2MAPK10, CCK
34cyclic amp45 2410.2MAPK10, OPRM1, NPFF
35nmda45 2910.1MAPK10, GRIN3B, OPRM1
36morphine45 51 29 1111.9NPFF, OPRM1, MAPK10, CCK
37calcium45 51 24 1111.0CCK, MAPK10, GRIN3B, OPRM1, NPFF

GO Terms for genes affiliated with Opioid Abuse

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Sources:
16Gene Ontology
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Cellular components related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:0432049.4NPFF, CCK
2dendriteGO:0304258.3NPFF, GRIN3B, CCK

Biological processes related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of appetiteGO:0320999.6NPFF, CCK
2regulation of sensory perception of painGO:0519309.5NPFF, CCK
3activation of MAPK activityGO:0001879.4MAPK10, FRS2
4Fc-epsilon receptor signaling pathwayGO:0380959.4MAPK10, FRS2
5neuropeptide signaling pathwayGO:0072189.3OPRM1, NPFF
6positive regulation of cytosolic calcium ion concentrationGO:0072049.1NPFF, OPRM1

Molecular functions related to Opioid Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPFF, CCK

Products for genes affiliated with Opioid Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opioid Abuse

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet