MCID: OPS001
MIFTS: 48

Opisthorchiasis malady

Rare diseases, Infectious diseases, Liver diseases categories

Summaries for Opisthorchiasis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by opisthorchis viverrini or opisthorchis felineus. the symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards: Opisthorchiasis, also known as infection due to cat liver fluke, is related to hepatitis and fascioliasis. An important gene associated with Opisthorchiasis is KRT9 (keratin 9), and among its related pathways are Selected targets of GCR alpha and Legionellosis. The drugs albendazole and praziquantel and the compounds bis(2-chloroethyl)sulfide and survanta have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes.

Wikipedia:66 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Aliases & Classifications for Opisthorchiasis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

opisthorchiasis 9 44 11 46 63
infection due to cat liver fluke 44
infection due to opisthorchis 44
infection by opisthorchis 9


External Ids:

Disease Ontology9 DOID:13768
ICD9CM28 121.0
SNOMED-CT59 1059007, 187124006
MeSH36 D009889
ICD1026 B66.0

Related Diseases for Opisthorchiasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6GGT1, GPT
2fascioliasis30.5GGT1, EPGN
3cholangitis30.1GPT, GGT1
4cholestasis30.0GGT1, GPT
5diabetes mellitus29.9GPT, IL1B, GGT1
6cholangiocarcinoma10.6
7clonorchiasis10.4
8sinusitis10.1IGES
9fatty liver disease10.1GGT1
10obstructive jaundice10.1GPT, GGT1
11choledocholithiasis10.1GPT, GGT1
12pulmonary eosinophilia10.1IL8, GGT1
13muckle-wells syndrome10.1IL1B
14cholelithiasis10.1GGT1, GPT
15portal hypertension10.1GGT1, GPT
16bilirubin metabolic disorder10.1GPT, GGT1
17alcohol abuse10.1GPT, GGT1
18biliary atresia10.1GPT, GGT1
19primary sclerosing cholangitis10.1GGT1, GPT
20vernal keratoconjunctivitis10.1IGES, IL8
21congenital stationary night blindness, type 1f10.1GPT, GGT1
22hyperuricemia10.1GGT1, GPT
23bronchiectasis10.1IL8, IGES
24autoimmune hepatitis10.1GGT1, GPT
25skin disease10.1IL1B
26hepatitis b10.1GPT, GGT1
27galactosemia10.0GGT1, GPT
28rhinitis10.0IL8, IGES
29viral hepatitis10.0GGT1, GPT
30otitis media10.0IL1B, IGES
31alcoholic hepatitis10.0GGT1, IL8, GPT
32alcoholic liver cirrhosis10.0GPT, IL8, GGT1
33bacterial vaginosis10.0IL8, IL1B
34chorioamnionitis10.0IL1B, IL8
35bacterial meningitis10.0IL8, IL1B
36arthritis10.0IL8, IL1B
37mastitis10.0IL8, IL1B
38pancreatitis10.0IGES, IL1B, GGT1
39adult respiratory distress syndrome10.0IL1B, IL8
40newborn respiratory distress syndrome10.0IL8, IL1B
41meningitis10.0IL8, IL1B
42periodontitis10.0IL1B, IL8
43synovitis10.0IL1B, IL8
44paragonimiasis10.0
45fasciolopsiasis10.0
46duodenitis10.0
47primary biliary cirrhosis10.0
48gallbladder disease10.0
49gastritis10.0
50glomerulonephritis10.0

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Symptoms for Opisthorchiasis

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Drugs & Therapeutics for Opisthorchiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Opisthorchiasis

Drug clinical trials:

Search ClinicalTrials for Opisthorchiasis

Search NIH Clinical Center for Opisthorchiasis

Search CenterWatch for Opisthorchiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Opisthorchiasis

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Anatomical Context for Opisthorchiasis

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34MalaCards
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MalaCards organs/tissues related to Opisthorchiasis:

34
Liver, Pancreas, Testes

Animal Models for Opisthorchiasis or affiliated genes

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Publications for Opisthorchiasis

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Sources:
53PubMed
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Articles related to Opisthorchiasis:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. (24122204)
2013
2
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
3
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. (21704727)
2012
4
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. (22186974)
2012
5
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. (22160279)
2012
6
Discovery of human opisthorchiasis: a mysterious history. (21867771)
2012
7
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. (23480766)
2012
8
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. (20446100)
2011
9
Histopathological diagnosis of opisthorchiasis in an immigrant. (20889856)
2010
10
Opisthorchis viverrini: evaluation of 28 kDa glutathione S-transferase as diagnostic tool in human opisthorchiasis. (20096257)
2010
11
Iso-electricfocusing of Bithynia snail antigens for IgG- and IgG(1-4)-ELISA detection of human opisthorchiasis. (21073055)
2010
12
Dynamics of pro-and anti-inflammatory cytokines at patients with combination of chronic opisthorchiasis with Helicobacter pylori-associated gastritis]. (19551959)
2009
13
Turmeric reduces inflammatory cells in hamster opisthorchiasis. (19633869)
2009
14
Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression. (20578454)
2009
15
Local perceptions and practices in regard to opisthorchiasis in two villages in Lao PDR. (18567439)
2008
16
Opisthorchiasis in Thailand: review and current status. (18416453)
2008
17
Apoptosis-related gene expression in hamster opisthorchiasis post praziquantel treatment. (18058134)
2008
18
Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). (15948244)
2005
19
Analysis of a complex of biochemical parameters of hepatic functions in opisthorchiasis]. (16445232)
2005
20
Biliary liver flukes (Opisthorchiasis and Clonorchiasis) in immigrants in the United States: often subtle and diagnosed years after arrival. (15710057)
2004
21
Opisthorchis viverrini and opisthorchiasis: The 21st Century review. Proceedings of the Congress of Opisthorchiasis and Cholangiocarcinoma. May 28-30, 2002. Khon Kaen, Thailand. (14763464)
2003
22
Pathobiology of opisthorchiasis: an update. (14611875)
2003
23
Ultrastructural analysis of liver biopsy specimens in diabetes mellitus associated with chronic opisthorchiasis. (12152884)
2001
24
Epidemiology of opisthorchiasis and national control program in Thailand. (9886122)
1998
25
Place of surgery in opisthorchiasis associated cholangiocarcinoma. (9656356)
1997
26
Evaluation of Bithynia funiculata snail antigens by ELISA-serodiagnosis of human opisthorchiasis. (9561614)
1997
27
Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease]. (9026671)
1996
28
Serum antibody responses in opisthorchiasis. (8550296)
1995
29
Serum antibody response to Opisthorchis viverrini antigen as a marker for opisthorchiasis-associated cholangiocarcinoma. (7570848)
1994
30
Changes in serum antibodies to Opisthorchis viverrini in humans and hamsters following treatment of opisthorchiasis. (7872997)
1994
31
Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma. (1653472)
1991
32
The serum immunoglobulin E level and the endocrine activity of the stomach, duodenum and pancreas after recovery from opisthorchiasis]. (2233534)
1990
33
Fecal egg output in relation to worm burden and clinical features in human opisthorchiasis. (2237595)
1990
34
Biliary bile acids and lipids composition in Opisthorchiasis viverrini. (3241137)
1988
35
A characteristic immunoblotting pattern for Opisthorchiasis sera with metacercarial antigens. (3233789)
1988
36
Detection of antibodies in sera from patients with Opisthorchiasis. (3486979)
1986
37
Studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection. (3906918)
1985
38
Public health aspects of opisthorchiasis in Thailand. (6542380)
1984
39
Computed tomography in opisthorchiasis. (6529907)
1984
40
Clonorchiasis/opisthorchiasis in South Carolina. (6572766)
1983
41
Increased efficacy of liposomes-encapsulated praziquantel in treatment of opisthorchiasis in hamsters. (6673127)
1983
42
Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. (6983303)
1982
43
Alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin in human liver fluke (opisthorchiasis). (6182657)
1982
44
Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel. (7342331)
1981
45
Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. (7020093)
1981
46
Polyacrylamide gel electrophoresis of human serum in subclinical opisthorchiasis. (4432102)
1974
47
Serum vitamin B 12 level in patients with amoebic liver abscess, opisthorchiasis and hookworm infections. (5112336)
1971
48
Opisthorchiasis with pulmonary involvement. (13738024)
1961
49
Fasciolopsiasis and opisthorchiasis as helminthic components of tropical public health. (13435416)
1957
50
Retention cyst of liver caused by opisthorchiasis associated with carcinoma; case report. (14361385)
1955

Variations for Opisthorchiasis

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Expression for genes affiliated with Opisthorchiasis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

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51PathCards, 13EMD Millipore, 31KEGG, 54QIAGEN
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Pathways related to Opisthorchiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL1B, IL8
29.8IL1B, IL8
39.8IL1B, IL8
49.8IL1B, IL8

Compounds for genes affiliated with Opisthorchiasis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Opisthorchiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide4610.2IL1B, IL8
2survanta4610.2IL8, IL1B
3echinacea4610.2IL8, IL1B
4tlck4610.2IL1B, IL8
5lxa44610.2IL1B, IL8
6aminooxyacetic acid46 3011.2GPT, GGT1
7monosodium urate4610.2IL8, IL1B
8muramyl dipeptide46 3011.2IL1B, IL8
9taurine chloramine4610.2IL1B, IL8
10hbd24610.2IL8, IL1B
11toxin-14610.2IL1B, IL8
12aminopyrine4610.2GGT1, GPT
13mip 1alpha4610.1IL1B, IL8
14gold sodium thiomalate4610.1IL8, IL1B
15clarithromycin46 1211.1GPT, IL8
16nash4610.1GGT1, GPT
17flagellin46 3011.1IL8, IL1B
18nevirapine46 52 1212.1GGT1, GPT
19il-124610.1IL8, IL1B
205 aminosalicylic acid4610.1IL1B, IL8
21sevoflurane52 46 1212.1GGT1, GPT
22staurosporin4610.1IL1B, IL8
23hcec4610.1IL8, GGT1
24tpck4610.1IL1B, IL8
25polymyxin b4610.1IL1B, IL8
26groalpha4610.0IL8, IL1B
27isoflurane52 46 1212.0GGT1, GPT
28anaphylatoxin4610.0IL1B, IL8
29gm-csf46 3011.0IL1B, IL8
30triptolide4610.0IL8, IL1B
31budesonide46 52 1212.0IL8, IL1B
32ciglitazone46 3011.0IL1B, IL8
33sulfasalazine30 46 52 1212.9IL8, IL1B
34lipoteichoic acid469.9IL8, IL1B
35neopterin469.9IL8, IL1B, GPT
36fluticasone propionate46 52 62 1212.9IL8, IL1B
37troglitazone46 30 62 1212.8GPT, IL8, IL1B
38s-nitroso-n-acetylpenicillamine469.8IL8, IL1B
39pentoxifylline46 1210.8IL1B, IL8, GGT1
40ns 39846 6210.8IL8, IL1B
41bezafibrate46 30 1211.7GGT1, GPT
42curcumin469.7IL1B, IL8, GGT1
43methotrexate52 46 1211.7IL1B, GPT, GGT1
44polyinosinic-polycytidylic acid469.7IL8, IL1B
45vitamin-e469.7GPT, GGT1, IGES
46hyaluronic acid46 2510.5GGT1, IL1B, IL8, GPT
47n acetylcysteine469.5IL8, GGT1, GPT, IL1B
48phosphorus469.4INTS9, GPT, GGT1
49lactate469.3IGES, GPT, IL8, GGT1
50histamine46 30 2510.9IL8, IGES, IL1B

GO Terms for genes affiliated with Opisthorchiasis

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17Gene Ontology
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Biological processes related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitosisGO:0458409.7IL1B, EPGN
2neutrophil chemotaxisGO:0305939.7IL1B, IL8
3negative regulation of cell proliferationGO:0082859.5SKI, IL1B, IL8
4lipid transportGO:0068699.0OSBP2, OSBPL7

Molecular functions related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.3OSBP2, OSBPL7

Products for genes affiliated with Opisthorchiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opisthorchiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet