MCID: OPS001
MIFTS: 39

Opisthorchiasis malady

Infectious, Liver categories

Summaries for Opisthorchiasis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by opisthorchis viverrini or opisthorchis felineus. the symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards: Opisthorchiasis, also known as infection due to cat liver fluke, is related to clonorchiasis and hepatitis e. An important gene associated with Opisthorchiasis is KRT9 (keratin 9). The drugs albendazole and praziquantel and the compounds bis(2-chloroethyl)sulfide and survanta have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and b cells.

Wikipedia:64 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Aliases & Classifications for Opisthorchiasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Liver


Aliases & Descriptions:

opisthorchiasis 8 43 10 45 61
infection due to cat liver fluke 43
infection due to opisthorchis 43
infection by opisthorchis 8


External Ids:

Disease Ontology8 DOID:13768
MeSH35 D009889
SNOMED-CT57 187124006, 1059007
ICD9CM27 121.0
ICD1025 B66.0

Related Diseases for Opisthorchiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1clonorchiasis30.6CTSF, EPGN, TSPAN2
2hepatitis e29.9GPT
3fascioliasis10.2
4pancreas disease10.0GGT1
5cholangiocarcinoma10.0GGT1
6thrombocytopenia10.0GPT
7hepatitis c10.0
8primary biliary cirrhosis10.0
9paragonimiasis10.0
10hepatitis d10.0
11fasciolopsiasis10.0
12hepatitis a10.0
13bacteremia10.0
14nephrotic syndrome10.0IGES
15schistosomiasis10.0TSPAN2, EPGN
16graves' disease10.0IGES
17hyperuricemia10.0GGT1, GPT
18biliary atresia10.0GGT1, GPT
19acute myocardial infarction10.0IGES
20hypercholesterolemia10.0GPT, GGT1
21myocardial infarction10.0IGES
22obstructive jaundice10.0GPT, GGT1
23liver cirrhosis10.0GGT1, GPT
24choledocholithiasis10.0GGT1, GPT
25cholangitis10.0GPT, GGT1
26coronary heart disease10.0GGT1
27hepatitis b10.0GGT1, GPT
28bilirubin metabolic disorder10.0GPT, GGT1
29portal hypertension10.0GPT, GGT1
30hypertriglyceridemia10.0GPT, GGT1
31muckle-wells syndrome10.0IL1B
32respiratory failure10.0IL1B
33glomerulonephritis10.0IL1B
34acute pancreatitis10.0GPT, IL8
35hypersensitivity reaction type ii disease10.0IL1B
36eosinophilia10.0IGES, IL8
37bronchiectasis10.0IL8, IGES
38cystic fibrosis10.0IGES, IL8
39pulmonary eosinophilia10.0GGT1, IL8
40alcoholic hepatitis10.0GGT1, GPT, IL8
41alcoholic liver cirrhosis10.0GGT1, GPT, IL8
42gingivitis10.0IL1B
43primary sclerosing cholangitis10.0GGT1, GPT
44vernal keratoconjunctivitis10.0IGES, IL8
45otitis media10.0IGES, IL1B
46mastitis10.0IL8, IL1B
47bacterial meningitis10.0IL1B, IL8
48arthritis10.0IL1B, IL8
49cork-handlers' disease10.0IL1B, IL8, IGES
50viral infectious disease10.0IGES, IL8, IL1B, GPT, GGT1

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Clinical Features for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Opisthorchiasis

Drug clinical trials:

Search ClinicalTrials for Opisthorchiasis

Search NIH Clinical Center for Opisthorchiasis

Search CenterWatch for Opisthorchiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Opisthorchiasis:

33
Liver, Pancreas, B cells

Animal Models for Opisthorchiasis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Opisthorchiasis

Sources:
51PubMed
See all sources

Articles related to Opisthorchiasis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
2
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. (23717698)
2013
3
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. (23052766)
2013
4
Development of a community-based approach to opisthorchiasis control. (24377646)
2013
5
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. (24349600)
2013
6
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. (24055716)
2013
7
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. (21704727)
2012
8
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. (22160279)
2012
9
Discovery of human opisthorchiasis: a mysterious history. (21867771)
2012
10
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. (21704728)
2012
11
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. (21763455)
2012
12
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. (20446100)
2011
13
Turmeric reduces inflammatory cells in hamster opisthorchiasis. (19633869)
2009
14
Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression. (20578454)
2009
15
Local perceptions and practices in regard to opisthorchiasis in two villages in Lao PDR. (18567439)
2008
16
Evaluation of PCR based coprodiagnosis of human opisthorchiasis. (16253202)
2006
17
Opisthorchiasis-associated biliary stones: light and scanning electron microscopic study. (15484308)
2004
18
Opisthorchiasis from imported raw fish. (15663848)
2004
19
Cytokine profile and immune status of patients with chronic glomerulonephritis concomitant with chronic opisthorchiasis. (16134818)
2004
20
Opisthorchis viverrini and opisthorchiasis: The 21st Century review. Proceedings of the Congress of Opisthorchiasis and Cholangiocarcinoma. May 28-30, 2002. Khon Kaen, Thailand. (14763464)
2003
21
Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function]. (12886584)
2003
22
Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand. (14611879)
2003
23
Opisthorchiasis and intestinal fluke infections in northern Thailand. (9740284)
1998
24
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini. (8896890)
1996
25
Serum antibody responses in opisthorchiasis. (8550296)
1995
26
Opisthorchiasis control in northeast Thailand: proposal for a new approach. (8087151)
1994
27
Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma. (1653472)
1991
28
A case of opisthorchiasis diagnosed by cholangiography and bile examination. (2053739)
1991
29
Immunodiagnosis of opisthorchiasis. (1822882)
1991
30
The serum immunoglobulin E level and the endocrine activity of the stomach, duodenum and pancreas after recovery from opisthorchiasis]. (2233534)
1990
31
Ultrasonographic study of the biliary system in opisthorchiasis patients after treatment with praziquantel. (2672363)
1989
32
Incidence of bacteremia in patients with opisthorchiasis during recurrent cholangitis. (3227401)
1988
33
Characterization of humoral immune response in the serum and bile of patients with opisthorchiasis and its application in immunodiagnosis. (3354768)
1988
34
High urinary excretion of nitrate and N-nitrosoproline in opisthorchiasis subjects. (3679440)
1987
35
Clinical field trial of praziquantel in opisthorchiasis in Nong Rangya Village, Khon Kaen Province, Thailand. (3738609)
1986
36
Studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection. (3906918)
1985
37
Public health aspects of opisthorchiasis in Thailand. (6542380)
1984
38
Infection and re-infection rates of opisthorchiasis in the water resource development area of Nam Pong project, Khon Kaen Province, northeast Thailand. (6532334)
1984
39
Therapeutic results in opisthorchiasis with praziquantel in a reinfection-free environment in France. (6542388)
1984
40
Clonorchiasis/opisthorchiasis in South Carolina. (6572766)
1983
41
Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. (6983303)
1982
42
Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. (7020093)
1981
43
Field trial of praziquantel in human opisthorchiasis in Thailand. (7344110)
1981
44
Opisthorchiasis: a clinicopathologic study of 154 autopsy cases. (212836)
1978
45
Carcinoma of the cystic duct associated with opisthorchiasis. (1030849)
1976
46
A clinical trial of oral dehydroemetine in opisthorchiasis. (4617315)
1974
47
Pathology of liver and pancreas in opisthorchiasis noverca in dogs and pigs. (5103963)
1971
48
Biliary tract changes in opisthorchiasis. (5093663)
1971
49
Opisthorchiasis in Thailand. (14399806)
1960
50
Fasciolopsiasis and opisthorchiasis as helminthic components of tropical public health. (13435416)
1957

Genetic Variations for Opisthorchiasis

Expression for genes affiliated with Opisthorchiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

Compounds for genes affiliated with Opisthorchiasis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Opisthorchiasis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide4510.3IL1B, IL8
2survanta4510.3IL1B, IL8
3aminooxyacetic acid45 2911.3GPT, GGT1
4echinacea4510.3IL8, IL1B
5tlck4510.2IL1B, IL8
6muramyl dipeptide45 2911.2IL8, IL1B
7lxa44510.2IL8, IL1B
8monosodium urate4510.2IL8, IL1B
9aminopyrine4510.2GGT1, GPT
10taurine chloramine4510.2IL1B, IL8
11toxin-14510.2IL8, IL1B
12hbd24510.2IL8, IL1B
13mip 1alpha4510.1IL1B, IL8
14gold sodium thiomalate4510.1IL8, IL1B
15hcec4510.1IL8, GGT1
16nash4510.1GPT, GGT1
17nevirapine45 50 1112.0GGT1, GPT
18neopterin4510.0GPT, IL1B, IL8
19sevoflurane45 1111.0GPT, GGT1
20pentoxifylline45 1110.9GGT1, IL1B, IL8
215 aminosalicylic acid459.9IL1B, IL8
22flagellin45 2910.9IL1B, IL8
23troglitazone45 29 60 1112.9GPT, IL1B, IL8
24clarithromycin45 1110.8GPT, IL8
25phosphorus459.8INTS9, GPT, GGT1
26vitamin-e459.7IGES, GPT, GGT1
27hyaluronic acid45 2410.7GGT1, GPT, IL1B, IL8
28n acetylcysteine459.7IL8, IL1B, GPT, GGT1
29il-12459.6IL1B, IL8
30lactate459.3GGT1, GPT, IL8, IGES

GO Terms for genes affiliated with Opisthorchiasis

Sources:
16Gene Ontology
See all sources

Biological processes related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid transportGO:0068698.7OSBP2, OSBPL8, OSBPL7

Molecular functions related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154858.7OSBP2, OSBPL8, OSBPL7

Products for genes affiliated with Opisthorchiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opisthorchiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet