MCID: OPS001
MIFTS: 36

Opisthorchiasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Opisthorchiasis

About this section

Aliases & Descriptions for Opisthorchiasis:

Name: Opisthorchiasis 11 48 50 39 13 68
Infection Due to Cat Liver Fluke 48
 
Infection Due to Opisthorchis 48
Infection by Opisthorchis 11

Classifications:



External Ids:

Disease Ontology11 DOID:13768
ICD1030 B66.0
SNOMED-CT62 1059007, 187124006
ICD9CM32 121.0
MeSH39 D009889

Summaries for Opisthorchiasis

About this section
Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary: Opisthorchiasis, also known as infection due to cat liver fluke, is related to conidiobolomycosis and psychotic disorder. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs albendazole and praziquantel have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes.

Wikipedia:71 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

About this section

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1conidiobolomycosis10.1CXCL8, IL4
2psychotic disorder10.1CXCL8, IL4
3retinal vascular disease10.1CXCL8, IL4
4breast intracanalicular fibroadenoma10.1CXCL8, IL4
5breast papillary carcinoma10.1CXCL8, IL6R
6rosacea10.1GPT, IL1B
7vitreoretinopathy, neovascular inflammatory10.1CXCL8, IL6R
8ileocolitis10.1IL1B, IL4
9clonorchiasis10.1
10oculomotor nerve paralysis10.1CXCL8, IL1B
11megaloblastic anemia10.1GPT, IL1B
12common peroneal nerve lesion10.1CXCL8, IL1B
13histoplasmosis retinitis10.1IL1B, IL4
14childhood electroclinical syndrome10.1CXCL8, IL1B
15lacrimal apparatus disease10.0CXCL8, IL1B
16hepatitis10.0
17amyotrophic lateral sclerosis type 1410.0CXCL8, IL1B
18parkinson disease 1110.0CXCL8, IL1B
19bullous retinoschisis10.0CXCL8, IL1B
20mikulicz disease10.0IL1B, IL4
21carbuncle10.0CXCL8, IL1B
22larynx leiomyoma10.0CXCL8, IL1B
23plantar wart10.0CTSF, CXCL8
24senile reticular retinal degeneration10.0CXCL8, IL1B
25coenurosis10.0IL1B, IL4
26hidradenitis9.9CXCL8, IL1B
27autosomal recessive type iv ehlers-danlos syndrome9.9CXCL8, IL1B, IL4
28nasopharyngitis9.9CXCL8, IL1B, IL4
29balkan nephropathy9.9CXCL8, IL1B, IL4
30colon adenocarcinoma9.9CXCL8, IL1B, IL4
31blue toe syndrome9.9CXCL8, IL1B, IL4
32parasitic protozoa infectious disease9.9CXCL8, IL1B, IL4
33keratomalacia9.9CXCL8, IL1B, IL4
34gonococcal endophthalmia9.9IL1B, IL4
35spontaneous ocular nystagmus9.9CXCL8, IL1B, IL4
36pigmentation disease9.9CXCL8, IL1B, IL4
37bare lymphocyte syndrome, type i9.9CXCL8, IL1B, IL4
38acquired thrombocytopenia9.9CXCL8, IL1B
39bone angioendothelial sarcoma9.9CXCL8, IL1B, IL4
40acute chest syndrome9.9CXCL8, IL1B, IL4
41nervous system cancer9.9CXCL8, IL1B, IL4
42blepharochalasis9.9AFP, CXCL8, IL1B
43spinal multifocal clear cell meningioma9.9AFP, CXCL8, IL1B
44collagenous colitis9.9CXCL8, IL1B, IL4
45thymus adenosquamous carcinoma9.9CXCL8, IL1B, IL4
46subcorneal pustular dermatosis9.9CXCL8, IL1B, IL4
47fascioliasis9.9
48childhood malignant hemangiopericytoma9.9AFP, CXCL8, IL1B
49glycogen storage disease ix9.9CXCL8, IL1B, IL4
50ectodermal dysplasia bartalos type9.8IL1B, IL4

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

About this section

Drugs & Therapeutics for Opisthorchiasis

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

About this section

Anatomical Context for Opisthorchiasis

About this section

MalaCards organs/tissues related to Opisthorchiasis:

36
Liver, Pancreas, Testes

Publications for Opisthorchiasis

About this section

Articles related to Opisthorchiasis:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. (26817235)
2016
2
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. (27482325)
2016
3
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. (27576001)
2016
4
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. (27507639)
2016
5
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. (27890720)
2016
6
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. (27140305)
2016
7
Ultrasonographic features of hepatobiliary in opisthorchiasis. (27956092)
2016
8
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? (27919744)
2016
9
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. (27939972)
2016
10
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. (25836376)
2015
11
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. (26312563)
2015
12
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. (26602874)
2015
13
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. (26344868)
2015
14
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. (26108023)
2015
15
Opisthorchiasis: an overlooked danger. (25836334)
2015
16
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. (25877389)
2015
17
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. (26625799)
2015
18
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. (26485024)
2015
19
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. (25041016)
2014
20
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. (25102053)
2014
21
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. (25188119)
2014
22
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. (23052766)
2013
23
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. (24516289)
2013
24
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. (24349600)
2013
25
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
26
Development of a community-based approach to opisthorchiasis control. (24377646)
2013
27
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. (24055716)
2013
28
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. (24122204)
2013
29
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. (23717698)
2013
30
Does a combination of opisthorchiasis and ethyl alcohol consumption enhance early cholangiofibrosis, the risk of cholangiocarcinoma? (23807659)
2013
31
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. (23188705)
2013
32
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. (21704728)
2012
33
Discovery of human opisthorchiasis: a mysterious history. (21867771)
2012
34
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. (22186974)
2012
35
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. (21893213)
2012
36
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. (21704727)
2012
37
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. (22160279)
2012
38
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. (21843654)
2012
39
Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. (21704729)
2012
40
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. (23480766)
2012
41
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. (21763455)
2012
42
A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. (21938537)
2012
43
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis. (22327320)
2012
44
Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. (20655862)
2011
45
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. (20446100)
2011
46
Histopathological diagnosis of opisthorchiasis in an immigrant. (20889856)
2010
47
Iso-electricfocusing of Bithynia snail antigens for IgG- and IgG(1-4)-ELISA detection of human opisthorchiasis. (21073055)
2010
48
Opisthorchis viverrini: evaluation of 28 kDa glutathione S-transferase as diagnostic tool in human opisthorchiasis. (20096257)
2010
49
Opisthorchiasis mimicking primary biliary cirrhosis as an indication for liver transplantation. (19329217)
2009
50
Dynamics of pro-and anti-inflammatory cytokines at patients with combination of chronic opisthorchiasis with Helicobacter pylori-associated gastritis]. (19551959)
2009

Variations for Opisthorchiasis

About this section

Expression for genes affiliated with Opisthorchiasis

About this section
Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

About this section

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.4IL1B, IL4
29.4IL1B, IL4
39.4IL1B, IL4
4
Show member pathways
9.1IL1B, IL4, IL6R
59.1IL1B, IL4, IL6R
69.1AFP, CXCL8, IL4
79.0CXCL8, IL1B, IL6R
89.0CXCL8, IL1B, IL6R
98.9CXCL8, IL1B, IL4
108.9CXCL8, IL1B, IL4
11
Show member pathways
8.9CXCL8, IL1B, IL4
128.9CXCL8, IL1B, IL4
138.9CXCL8, IL1B, IL4
14
Show member pathways
8.9CXCL8, IL1B, IL4
158.6CXCL8, IL1B, IL4, IL6R
16
Show member pathways
8.6CXCL8, IL1B, IL4, IL6R

GO Terms for genes affiliated with Opisthorchiasis

About this section

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5AFP, CXCL8, IL1B, IL4, IL6R, MFGE8
2extracellular spaceGO:00056156.6AFP, CTSF, CXCL8, GPT, IL1B, IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.0IL1B, IL4
2positive regulation of chemokine biosynthetic processGO:00450809.9IL1B, IL4
3positive regulation of interleukin-6 productionGO:00327559.9IL1B, IL6R
4positive regulation of phagocytosisGO:00507669.6IL1B, MFGE8

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9CXCL8, IL1B, IL4

Sources for Opisthorchiasis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet