MCID: OPS001
MIFTS: 44

Opisthorchiasis malady

Infectious diseases, Liver diseases categories

Summaries for Opisthorchiasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by opisthorchis viverrini or opisthorchis felineus. the symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards: Opisthorchiasis, also known as infection due to cat liver fluke, is related to cholangiocarcinoma and clonorchiasis. An important gene associated with Opisthorchiasis is KRT9 (keratin 9). The drugs albendazole and praziquantel and the compounds bis(2-chloroethyl)sulfide and survanta have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes.

Wikipedia:63 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Aliases & Classifications for Opisthorchiasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

opisthorchiasis 8 42 10 44 60
infection due to cat liver fluke 42
infection due to opisthorchis 42
infection by opisthorchis 8


External Ids:

Disease Ontology8 DOID:13768
MeSH34 D009889
SNOMED-CT56 187124006, 1059007
ICD9CM27 121.0
ICD1025 B66.0

Related Diseases for Opisthorchiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.8GGT1
2clonorchiasis30.5TSPAN2, EPGN, CTSF
3liver cirrhosis29.9GPT, GGT1
4cholangitis29.9GPT, GGT1
5hepatitis b29.9GPT, GGT1
6glomerulonephritis29.9IL1B
7hepatitis10.3
8fascioliasis10.2
9hepatitis a10.1
10pancreas disease10.0GGT1
11hepatitis e10.0GPT
12thrombocytopenia10.0GPT
13nephrotic syndrome10.0IGES
14schistosomiasis10.0TSPAN2, EPGN
15graves' disease10.0IGES
16hyperuricemia10.0GGT1, GPT
17biliary atresia10.0GPT, GGT1
18acute myocardial infarction10.0IGES
19hypercholesterolemia10.0GGT1, GPT
20myocardial infarction10.0IGES
21obstructive jaundice10.0GGT1, GPT
22choledocholithiasis10.0GGT1, GPT
23coronary heart disease10.0GGT1
24portal hypertension10.0GGT1, GPT
25bilirubin metabolic disorder10.0GPT, GGT1
26hypertriglyceridemia10.0GPT, GGT1
27muckle-wells syndrome10.0IL1B
28respiratory failure10.0IL1B
29acute pancreatitis10.0GPT, IL8
30hypersensitivity reaction type ii disease10.0IL1B
31eosinophilia10.0IGES, IL8
32bronchiectasis10.0IL8, IGES
33cystic fibrosis10.0IGES, IL8
34pulmonary eosinophilia10.0GGT1, IL8
35alcoholic hepatitis10.0GGT1, GPT, IL8
36alcoholic liver cirrhosis10.0GGT1, IL8, GPT
37gingivitis10.0IL1B
38primary sclerosing cholangitis10.0GPT, GGT1
39vernal keratoconjunctivitis10.0IL8, IGES
40otitis media10.0IL1B, IGES
41mastitis10.0IL8, IL1B
42bacterial meningitis10.0IL1B, IL8
43arthritis10.0IL1B, IL8
44cork-handlers' disease10.0IL1B, IL8, IGES
45viral infectious disease10.0IGES, IL1B, GGT1, GPT, IL8
46primary biliary cirrhosis9.9
47paragonimiasis9.9
48fasciolopsiasis9.9
49duodenitis9.9
50cholestasis9.9

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Clinical Features for Opisthorchiasis

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Drugs & Therapeutics for Opisthorchiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opisthorchiasis

Drug clinical trials:

Search ClinicalTrials for Opisthorchiasis

Search NIH Clinical Center for Opisthorchiasis

Search CenterWatch for Opisthorchiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Opisthorchiasis

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Anatomical Context for Opisthorchiasis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Opisthorchiasis:

32
Liver, Pancreas, Testes

Animal Models for Opisthorchiasis or affiliated genes

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Publications for Opisthorchiasis

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Sources:
50PubMed
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Articles related to Opisthorchiasis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. (24122204)
2013
2
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
3
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. (23052766)
2013
4
Development of a community-based approach to opisthorchiasis control. (24377646)
2013
5
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. (24349600)
2013
6
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. (23188705)
2013
7
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. (24055716)
2013
8
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. (22160279)
2012
9
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. (21843654)
2012
10
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. (20446100)
2011
11
Histopathological diagnosis of opisthorchiasis in an immigrant. (20889856)
2010
12
Dynamics of pro-and anti-inflammatory cytokines at patients with combination of chronic opisthorchiasis with Helicobacter pylori-associated gastritis]. (19551959)
2009
13
Turmeric reduces inflammatory cells in hamster opisthorchiasis. (19633869)
2009
14
Local perceptions and practices in regard to opisthorchiasis in two villages in Lao PDR. (18567439)
2008
15
Opisthorchiasis in Thailand: review and current status. (18416453)
2008
16
Apoptosis-related gene expression in hamster opisthorchiasis post praziquantel treatment. (18058134)
2008
17
Biliary parasitic diseases including clonorchiasis, opisthorchiasis and fascioliasis. (17934771)
2008
18
Field testing of the WHO dose pole for administration of praziquantel in the treatment of opisthorchiasis in Lao PDR. (17764711)
2007
19
Evaluation of PCR based coprodiagnosis of human opisthorchiasis. (16253202)
2006
20
Opisthorchiasis from imported raw fish. (15663848)
2004
21
Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function]. (12886584)
2003
22
Clinical manifestation of opisthorchiasis and treatment. (14611876)
2003
23
Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand. (14611879)
2003
24
Allergic dermatoses associated with chronic opisthorchiasis during antihelminthic therapy. (12802461)
2002
25
Epidemiology of opisthorchiasis and national control program in Thailand. (9886122)
1998
26
Clinical and immune peculiarities of pseudotuberculous polyarthritis against a background of chronic opisthorchiasis. (9566679)
1998
27
Opisthorchiasis and intestinal fluke infections in northern Thailand. (9740284)
1998
28
The impact of a decade long opisthorchiasis control program in northeastern Thailand. (9561607)
1997
29
Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease]. (9026671)
1996
30
Cholangiocarcinoma in patients with opisthorchiasis. (8869303)
1996
31
Egg-negative residents of an Opisthorchiasis-endemic area possess high levels of anti-Opisthorchis antibodies. (7502941)
1995
32
Serum antibody response to Opisthorchis viverrini antigen as a marker for opisthorchiasis-associated cholangiocarcinoma. (7570848)
1994
33
The serum immunoglobulin E level and the endocrine activity of the stomach, duodenum and pancreas after recovery from opisthorchiasis]. (2233534)
1990
34
Incidence of bacteremia in patients with opisthorchiasis during recurrent cholangitis. (3227401)
1988
35
Characterization of humoral immune response in the serum and bile of patients with opisthorchiasis and its application in immunodiagnosis. (3354768)
1988
36
Lipid composition of serum lipoprotein in opisthorchiasis. (3250339)
1988
37
Detection of antibodies in sera from patients with Opisthorchiasis. (3486979)
1986
38
Studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection. (3906918)
1985
39
Opisthorchiasis and its associated diseases. (2993467)
1985
40
Public health aspects of opisthorchiasis in Thailand. (6542380)
1984
41
Infection and re-infection rates of opisthorchiasis in the water resource development area of Nam Pong project, Khon Kaen Province, northeast Thailand. (6532334)
1984
42
Treatment of Opisthorchiasis viverrini in hamsters with albendazole. (6523174)
1984
43
Mass treatment of opisthorchiasis in Northeast Thailand. (7170644)
1982
44
Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel. (7342331)
1981
45
Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. (7020093)
1981
46
The immunological diagnosis of human opisthorchiasis and the humoral immune response to opisthorchis infection in the hamster. (7430854)
1980
47
Ultrastructure of cholangiocarcinoma associated with opisthorchiasis. (220737)
1978
48
Polyacrylamide gel electrophoresis of human serum in subclinical opisthorchiasis. (4432102)
1974
49
Biliary tract changes in opisthorchiasis. (5093663)
1971
50
Fasciolopsiasis and opisthorchiasis as helminthic components of tropical public health. (13435416)
1957

Genetic Variations for Opisthorchiasis

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Expression for genes affiliated with Opisthorchiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

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Compounds for genes affiliated with Opisthorchiasis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Opisthorchiasis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide4410.3IL1B, IL8
2survanta4410.3IL1B, IL8
3aminooxyacetic acid44 2811.3GPT, GGT1
4echinacea4410.3IL8, IL1B
5tlck4410.2IL1B, IL8
6muramyl dipeptide44 2811.2IL8, IL1B
7lxa44410.2IL8, IL1B
8monosodium urate4410.2IL8, IL1B
9aminopyrine4410.2GGT1, GPT
10taurine chloramine4410.2IL1B, IL8
11toxin-14410.2IL8, IL1B
12hbd24410.2IL8, IL1B
13mip 1alpha4410.1IL1B, IL8
14gold sodium thiomalate4410.1IL8, IL1B
15hcec4410.1IL8, GGT1
16nash4410.1GPT, GGT1
17nevirapine44 49 1112.0GGT1, GPT
18neopterin4410.0GPT, IL1B, IL8
19sevoflurane44 1111.0GPT, GGT1
20pentoxifylline44 1110.9GGT1, IL1B, IL8
215 aminosalicylic acid449.9IL1B, IL8
22flagellin44 2810.9IL1B, IL8
23troglitazone44 28 59 1112.9GPT, IL1B, IL8
24clarithromycin44 1110.8GPT, IL8
25phosphorus449.8INTS9, GPT, GGT1
26vitamin-e449.7IGES, GPT, GGT1
27hyaluronic acid44 2410.7GGT1, GPT, IL1B, IL8
28n acetylcysteine449.7IL8, IL1B, GPT, GGT1
29il-12449.6IL1B, IL8
30lactate449.3GGT1, GPT, IL8, IGES

GO Terms for genes affiliated with Opisthorchiasis

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16Gene Ontology
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Biological processes related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid transportGO:0068698.7OSBP2, OSBPL8, OSBPL7

Molecular functions related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154858.7OSBP2, OSBPL8, OSBPL7

Products for genes affiliated with Opisthorchiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opisthorchiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet