MCID: OPS001
MIFTS: 38

Opisthorchiasis malady

Rare diseases, Infectious diseases, Liver diseases categories

Aliases & Classifications for Opisthorchiasis

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Aliases & Descriptions for Opisthorchiasis:

Name: Opisthorchiasis 10 45 47 12 65 36
Infection Due to Cat Liver Fluke 45 65
 
Infection Due to Opisthorchis 45
Infection by Opisthorchis 10


Classifications:



External Ids:

Disease Ontology10 DOID:13768
MeSH36 D009889
SNOMED-CT59 1059007, 187124006
ICD9CM29 121.0
ICD1027 B66.0

Summaries for Opisthorchiasis

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Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by opisthorchis viverrini or opisthorchis felineus. the symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary: Opisthorchiasis, also known as infection due to cat liver fluke, is related to fasciolopsiasis and cholangiocarcinoma. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs praziquantel and albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes, and related mouse phenotype tumorigenesis.

Wikipedia:68 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

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Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1fasciolopsiasis30.4GPT, IL1B
2cholangiocarcinoma10.7
3clonorchiasis10.5
4hepatitis10.4
5fascioliasis10.3
6triple-receptor negative breast cancer10.2GPT, IL1B
7tyrosinemia10.2GPT, IL1B
8chemical colitis10.2IL1B, IL4
9morgagni cataract10.2IL1B, IL4
10early-onset, autosomal dominant alzheimer disease10.2IL1B, IL4
11thymus basaloid carcinoma10.2IL1B, IL4
12eye accommodation disease10.2IL1B, IL4
13sost-related sclerosing bone dysplasia10.2IL1B, IL4
14acute allergic serous otitis media10.2IL1B, IL4
15opioid abuse10.2AFP, GPT
16neuroendocrine tumor10.1IL1B, IL4
17kartagener syndrome10.1IL1B, IL6R
18balanitis xerotica obliterans10.1IL1B, IL4
19basidiobolomycosis10.0CXCL8, IL4
20papilledema10.0CXCL8, IL4
21cicatricial entropion10.0CXCL8, IL4
22sebaceous adenoma10.0CXCL8, IL4
23bacteremia10.0
24glomerulonephritis10.0
25liver disease10.0
26primary biliary cirrhosis10.0
27paragonimiasis10.0
28strongyloidiasis10.0
29duodenitis10.0
30cholangitis10.0
31cholestasis10.0
32gallbladder disease10.0
33gastritis10.0
34psoriasis10.0
35diabetic ketoacidosis10.0CXCL8, IL1B
36plantar nerve lesion10.0CXCL8, IL1B
37chorioamnionitis10.0CXCL8, IL1B
38dermatitis10.0CXCL8, IL1B
39uterine cervix leukoplakia10.0CXCL8, IL1B
40pneumonic tularemia10.0CXCL8, IL1B
41nosophobia10.0CXCL8, IL4
42vaginal glandular tumor10.0CXCL8, IL1B
43vascular cancer10.0CXCL8, IL1B
44vulvovaginal candidiasis10.0CXCL8, IL1B
45henoch-schoenlein purpura10.0CXCL8, IL1B
46childhood disintegrative disease10.0CXCL8, IL1B
47acute female pelvic peritonitis10.0CXCL8, IL1B
48allergic contact dermatitis10.0CXCL8, IL4
49primary systemic mycosis10.0IL1B, IL4
50uremia10.0CXCL8, IL4

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Symptoms for Opisthorchiasis

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Drugs & Therapeutics for Opisthorchiasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Opisthorchiasis

Genetic Tests for Opisthorchiasis

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Anatomical Context for Opisthorchiasis

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MalaCards organs/tissues related to Opisthorchiasis:

33
Liver, Pancreas, Testes

Animal Models for Opisthorchiasis or affiliated genes

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MGI Mouse Phenotypes related to Opisthorchiasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1AFP, IL1B, IL6R, KRT9, MFGE8

Publications for Opisthorchiasis

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Articles related to Opisthorchiasis:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. (26312563)
2015
2
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. (26108023)
2015
3
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. (24122204)
2013
4
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. (24018821)
2013
5
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. (21704727)
2012
6
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. (22186974)
2012
7
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. (22160279)
2012
8
Discovery of human opisthorchiasis: a mysterious history. (21867771)
2012
9
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. (23480766)
2012
10
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. (20446100)
2011
11
Histopathological diagnosis of opisthorchiasis in an immigrant. (20889856)
2010
12
Opisthorchis viverrini: evaluation of 28 kDa glutathione S-transferase as diagnostic tool in human opisthorchiasis. (20096257)
2010
13
Iso-electricfocusing of Bithynia snail antigens for IgG- and IgG(1-4)-ELISA detection of human opisthorchiasis. (21073055)
2010
14
Dynamics of pro-and anti-inflammatory cytokines at patients with combination of chronic opisthorchiasis with Helicobacter pylori-associated gastritis]. (19551959)
2009
15
Turmeric reduces inflammatory cells in hamster opisthorchiasis. (19633869)
2009
16
Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression. (20578454)
2009
17
Local perceptions and practices in regard to opisthorchiasis in two villages in Lao PDR. (18567439)
2008
18
Opisthorchiasis in Thailand: review and current status. (18416453)
2008
19
Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). (15948244)
2005
20
Analysis of a complex of biochemical parameters of hepatic functions in opisthorchiasis]. (16445232)
2005
21
Biliary liver flukes (Opisthorchiasis and Clonorchiasis) in immigrants in the United States: often subtle and diagnosed years after arrival. (15710057)
2004
22
Opisthorchis viverrini and opisthorchiasis: The 21st Century review. Proceedings of the Congress of Opisthorchiasis and Cholangiocarcinoma. May 28-30, 2002. Khon Kaen, Thailand. (14763464)
2003
23
Pathobiology of opisthorchiasis: an update. (14611875)
2003
24
Ultrastructural analysis of liver biopsy specimens in diabetes mellitus associated with chronic opisthorchiasis. (12152884)
2001
25
Epidemiology of opisthorchiasis and national control program in Thailand. (9886122)
1998
26
Place of surgery in opisthorchiasis associated cholangiocarcinoma. (9656356)
1997
27
Evaluation of Bithynia funiculata snail antigens by ELISA-serodiagnosis of human opisthorchiasis. (9561614)
1997
28
Serum antibody responses in opisthorchiasis. (8550296)
1995
29
Opisthorchiasis control in northeast Thailand: proposal for a new approach. (8087151)
1994
30
Serum antibody response to Opisthorchis viverrini antigen as a marker for opisthorchiasis-associated cholangiocarcinoma. (7570848)
1994
31
Changes in serum antibodies to Opisthorchis viverrini in humans and hamsters following treatment of opisthorchiasis. (7872997)
1994
32
Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma. (1653472)
1991
33
The serum immunoglobulin E level and the endocrine activity of the stomach, duodenum and pancreas after recovery from opisthorchiasis]. (2233534)
1990
34
Fecal egg output in relation to worm burden and clinical features in human opisthorchiasis. (2237595)
1990
35
Biliary bile acids and lipids composition in Opisthorchiasis viverrini. (3241137)
1988
36
A characteristic immunoblotting pattern for Opisthorchiasis sera with metacercarial antigens. (3233789)
1988
37
Detection of antibodies in sera from patients with Opisthorchiasis. (3486979)
1986
38
Public health aspects of opisthorchiasis in Thailand. (6542380)
1984
39
Computed tomography in opisthorchiasis. (6529907)
1984
40
Clonorchiasis/opisthorchiasis in South Carolina. (6572766)
1983
41
Increased efficacy of liposomes-encapsulated praziquantel in treatment of opisthorchiasis in hamsters. (6673127)
1983
42
Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. (6983303)
1982
43
Alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin in human liver fluke (opisthorchiasis). (6182657)
1982
44
Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel. (7342331)
1981
45
Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. (7020093)
1981
46
Polyacrylamide gel electrophoresis of human serum in subclinical opisthorchiasis. (4432102)
1974
47
Serum vitamin B 12 level in patients with amoebic liver abscess, opisthorchiasis and hookworm infections. (5112336)
1971
48
Opisthorchiasis with pulmonary involvement. (13738024)
1961
49
Fasciolopsiasis and opisthorchiasis as helminthic components of tropical public health. (13435416)
1957
50
Retention cyst of liver caused by opisthorchiasis associated with carcinoma; case report. (14361385)
1955

Variations for Opisthorchiasis

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Expression for genes affiliated with Opisthorchiasis

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Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

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GO Terms for genes affiliated with Opisthorchiasis

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Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicleGO:19035619.9CTSF, MFGE8
2extracellular regionGO:00055767.6CXCL8, IL1B, IL4, IL6R, MFGE8
3extracellular spaceGO:00056156.5AFP, CTSF, CXCL8, IL1B, IL4, IL6R

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine biosynthetic processGO:004508010.1IL1B, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.0IL1B, IL4
3response to gamma radiationGO:00103329.7IL1B, IL6R
4positive regulation of phagocytosisGO:00507669.6IL1B, MFGE8
5positive regulation of interleukin-6 productionGO:00327559.4IL1B, IL6R
6positive regulation of neutrophil chemotaxisGO:00900239.3CXCL8, IL1B
7response to ethanolGO:00454719.1IL1B, IL4, IL6R

Sources for Opisthorchiasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet