MCID: OPS001
MIFTS: 39

Opisthorchiasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Opisthorchiasis

MalaCards integrated aliases for Opisthorchiasis:

Name: Opisthorchiasis 12 49 51 41 14 69
Infection Due to Cat Liver Fluke 49
Infection Due to Opisthorchis 49
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD10 32 B66.0
ICD9CM 34 121.0
MeSH 41 D009889
SNOMED-CT 64 1059007 187124006
UMLS 69 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to fascioliasis and clonorchiasis. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 72 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 fascioliasis 30.5 GPT IL1B
2 clonorchiasis 30.2 CTSF CXCL8
3 cholangiocarcinoma 10.4
4 diversion colitis 10.3 IL1B IL4
5 scrub typhus 10.3 GPT IL1B
6 cercarial dermatitis 10.3 IL1B IL4
7 primary amebic meningoencephalitis 10.3 IL1B IL4
8 eales disease 10.3 IL1B IL4
9 tungiasis 10.3 CXCL8 IL4
10 papillary conjunctivitis 10.3 CXCL8 IL4
11 giant papillary conjunctivitis 10.3 CXCL8 IL4
12 aphthous stomatitis 10.2 IL1B IL4
13 hepatitis a 10.2 AFP GPT
14 extrinsic cardiomyopathy 10.2 IL1B IL4
15 keratoconjunctivitis sicca 10.2 IL1B IL4
16 recurrent corneal erosion 10.2 CXCL8 IL1B
17 bagassosis 10.2 CXCL8 IL1B
18 somatoform disorder 10.2 IL1B IL4
19 peptic esophagitis 10.2 CXCL8 IL1B
20 funisitis 10.2 CXCL8 IL1B
21 haemophilus influenzae 10.2 CXCL8 IL1B
22 allergic conjunctivitis 10.2 CXCL8 IL4
23 crohn's colitis 10.2 CXCL8 IL1B
24 dental pulp disease 10.2 CXCL8 IL1B
25 vaginal disease 10.2 CXCL8 IL1B
26 vaginitis 10.2 CXCL8 IL1B
27 nasal cavity disease 10.2 CXCL8 IL4
28 endometrial disease 10.2 CXCL8 IL1B
29 aseptic meningitis 10.2 CXCL8 IL1B
30 pulpitis 10.2 CXCL8 IL1B
31 pharyngitis 10.1 CXCL8 IL1B
32 wells syndrome 10.1 CXCL8 IL1B
33 newborn respiratory distress syndrome 10.1 CXCL8 IL1B
34 middle ear disease 10.1 CXCL8 IL1B
35 viral encephalitis 10.1 CXCL8 IL1B
36 hepatitis 10.1
37 perinatal necrotizing enterocolitis 10.1 CXCL8 IL1B
38 nose disease 10.1 CXCL8 IL4
39 acute respiratory distress syndrome 10.1 CXCL8 IL1B
40 interstitial cystitis 10.1 CXCL8 IL4
41 bacterial vaginosis 10.1 CXCL8 IL1B
42 prostatitis 10.1 CXCL8 IL1B
43 brucellosis 10.1 CXCL8 IL4
44 joint disorders 10.1 IL1B IL6R
45 gastric ulcer 10.1 CXCL8 IL1B
46 preterm premature rupture of the membranes 10.1 CXCL8 IL6R
47 leptospirosis 10.0 CXCL8 IL1B
48 lung giant cell carcinoma 10.0 CXCL8 IL6R
49 skin disease 10.0 CXCL8 IL4 KRT9
50 pyelonephritis 10.0 CXCL8 IL1B

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

38
Liver, Pancreas, Testes

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 173)
# Title Authors Year
1
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis. ( 28429227 )
2017
2
Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem. ( 28848361 )
2017
3
Opisthorchiasis, hypercholesterolemia, and cholangiocarcinoma: A reappraisal. ( 28413795 )
2017
4
Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus). ( 29088234 )
2017
5
Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. ( 28198451 )
2017
6
Social network analysis of food sharing among households in opisthorchiasis endemic villages of Lawa Lake, Thailand. ( 28188767 )
2017
7
Present Situation of Opisthorchiasis in Vientiane Capital, Lao Peoples' Democratic Republic. ( 28552889 )
2017
8
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. ( 27890720 )
2016
9
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. ( 27140305 )
2016
10
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? ( 27919744 )
2016
11
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. ( 27482325 )
2016
12
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. ( 27939972 )
2016
13
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. ( 27507639 )
2016
14
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. ( 26817235 )
2016
15
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. ( 27576001 )
2016
16
Ultrasonographic features of hepatobiliary in opisthorchiasis. ( 27956092 )
2016
17
Opisthorchiasis: an overlooked danger. ( 25836334 )
2015
18
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. ( 25877389 )
2015
19
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. ( 26312563 )
2015
20
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. ( 26485024 )
2015
21
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. ( 26602874 )
2015
22
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. ( 26344868 )
2015
23
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. ( 25836376 )
2015
24
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. ( 26108023 )
2015
25
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. ( 26625799 )
2015
26
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. ( 25188119 )
2014
27
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. ( 25041016 )
2014
28
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. ( 25102053 )
2014
29
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. ( 23188705 )
2013
30
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. ( 23052766 )
2013
31
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. ( 24018821 )
2013
32
Does a combination of opisthorchiasis and ethyl alcohol consumption enhance early cholangiofibrosis, the risk of cholangiocarcinoma? ( 23807659 )
2013
33
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. ( 24349600 )
2013
34
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. ( 24055716 )
2013
35
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. ( 23717698 )
2013
36
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. ( 24122204 )
2013
37
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. ( 24516289 )
2013
38
Development of a community-based approach to opisthorchiasis control. ( 24377646 )
2013
39
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. ( 21763455 )
2012
40
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. ( 22160279 )
2012
41
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. ( 21704727 )
2012
42
Discovery of human opisthorchiasis: a mysterious history. ( 21867771 )
2012
43
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. ( 23480766 )
2012
44
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis. ( 22327320 )
2012
45
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
46
Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. ( 21704729 )
2012
47
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. ( 21704728 )
2012
48
A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. ( 21938537 )
2012
49
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. ( 22186974 )
2012
50
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. ( 21843654 )
2012

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CXCL8 IL1B IL4
2 11.9 CXCL8 IL1B IL6R
3
Show member pathways
11.88 CXCL8 IL1B IL4
4
Show member pathways
11.79 CXCL8 IL1B IL4 IL6R
5 11.73 CXCL8 IL1B IL4
6 11.63 CXCL8 IL1B IL6R
7 11.57 IL1B IL4 IL6R
8
Show member pathways
11.5 IL1B IL4 IL6R
9 11.41 AFP CXCL8 IL4
10 11.23 CXCL8 IL1B IL4
11 11.06 IL1B IL4
12 11.02 IL1B IL4
13 10.98 CXCL8 IL1B IL4 IL6R
14 10.94 CXCL8 IL1B IL4
15 10.82 CXCL8 IL1B IL4
16 10.54 IL1B IL4

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AFP CXCL8 IL1B IL4 IL6R MFGE8
2 extracellular space GO:0005615 9.23 AFP CTSF CXCL8 GPT IL1B IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 8.96 IL1B IL6R
2 positive regulation of phagocytosis GO:0050766 8.62 IL1B MFGE8

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL4

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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