MCID: OPS001
MIFTS: 36

Opisthorchiasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Opisthorchiasis

MalaCards integrated aliases for Opisthorchiasis:

Name: Opisthorchiasis 12 50 52 42 14 69
Infection Due to Cat Liver Fluke 50
Infection Due to Opisthorchis 50
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD10 33 B66.0
ICD9CM 35 121.0
MeSH 42 D009889
SNOMED-CT 64 1059007 187124006
UMLS 69 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to basidiobolomycosis and psychotic disorder. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 72 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
id Related Disease Score Top Affiliating Genes
1 basidiobolomycosis 10.6 CXCL8 IL4
2 psychotic disorder 10.6 CXCL8 IL4
3 retinal vascular disease 10.6 CXCL8 IL4
4 osteogenesis imperfecta, type x 10.5 CXCL8 IL6R
5 oculomotor nerve paralysis 10.5 CXCL8 IL1B
6 common peroneal nerve lesion 10.5 CXCL8 IL1B
7 tonsil cancer 10.5 GPT IL1B
8 lung papillary adenocarcinoma 10.5 CXCL8 IL6R
9 lacrimal apparatus disease 10.5 CXCL8 IL1B
10 infancy electroclinical syndrome 10.5 CXCL8 IL1B
11 amyotrophic lateral sclerosis type 10 10.5 CXCL8 IL1B
12 epulis 10.5 CXCL8 IL1B
13 ileitis 10.5 IL1B IL4
14 subglottis neoplasm 10.5 CXCL8 IL1B
15 megaloblastic anemia 10.5 GPT IL1B
16 bullous retinoschisis 10.5 CXCL8 IL1B
17 carbuncle 10.5 CXCL8 IL1B
18 histoplasmosis retinitis 10.5 IL1B IL4
19 eyelid neoplasm 10.5 CXCL8 IL4
20 senile reticular retinal degeneration 10.5 CXCL8 IL1B
21 acute contagious conjunctivitis 10.4 CXCL8 IL4
22 acquired thrombocytopenia 10.4 CXCL8 IL1B
23 hidradenitis 10.4 CXCL8 IL1B
24 philophthalmiasis 10.4 IL1B IL4
25 whistling face syndrome, recessive form 10.4 CXCL8 IL1B
26 early-onset zonular cataract 10.4 IL1B IL4
27 testicular infarct 10.4 CXCL8 IL1B
28 ovarian mucinous adenofibroma 10.4 CXCL8 IL1B
29 myeloid sarcoma 10.4 CXCL8 IL1B
30 noma 10.4 IL1B IL4
31 ostertagiasis 10.4 IL1B IL4
32 keloids 10.4 IL1B IL6R
33 dehydration polycythemia 10.3 CXCL8 IL4
34 palmoplantar keratosis 10.3 CXCL8 IL1B
35 vacterl association 10.3 CXCL8 IL1B
36 mikulicz disease 10.3 IL1B IL4
37 tibialis tendinitis 10.3 CXCL8 IL1B
38 placenta accreta 10.3 IL1B IL4
39 atrophy of prostate 10.3 CXCL8 IL1B
40 esophagus melanoma 10.3 CXCL8 IL4
41 anal fistula 10.2 AFP CXCL8
42 fibrosarcomatous osteosarcoma 10.2 CXCL8 IL1B
43 legionellosis 10.2 CXCL8 IL1B IL4
44 autosomal recessive type iv ehlers-danlos syndrome 10.2 CXCL8 IL1B IL4
45 churg-strauss syndrome 10.2 CXCL8 IL1B IL4
46 colon adenocarcinoma 10.2 CXCL8 IL1B IL4
47 germ cell and embryonal cancer 10.2 CXCL8 IL1B IL4
48 spontaneous ocular nystagmus 10.2 CXCL8 IL1B IL4
49 ragweed sensitivity 10.2 CXCL8 IL1B IL4
50 blue toe syndrome 10.2 CXCL8 IL1B IL4

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

39
Liver, Pancreas, Testes

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 172)
id Title Authors Year
1
Present Situation of Opisthorchiasis in Vientiane Capital, Lao Peoples' Democratic Republic. ( 28552889 )
2017
2
Opisthorchiasis, hypercholesterolemia, and cholangiocarcinoma: A reappraisal. ( 28413795 )
2017
3
Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem. ( 28848361 )
2017
4
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis. ( 28429227 )
2017
5
Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. ( 28198451 )
2017
6
Social network analysis of food sharing among households in opisthorchiasis endemic villages of Lawa Lake, Thailand. ( 28188767 )
2017
7
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? ( 27919744 )
2016
8
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. ( 27507639 )
2016
9
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. ( 26817235 )
2016
10
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. ( 27140305 )
2016
11
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. ( 27576001 )
2016
12
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. ( 27482325 )
2016
13
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. ( 27890720 )
2016
14
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. ( 27939972 )
2016
15
Ultrasonographic features of hepatobiliary in opisthorchiasis. ( 27956092 )
2016
16
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. ( 26625799 )
2015
17
Opisthorchiasis: an overlooked danger. ( 25836334 )
2015
18
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. ( 26312563 )
2015
19
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. ( 25877389 )
2015
20
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. ( 26602874 )
2015
21
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. ( 26108023 )
2015
22
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. ( 26485024 )
2015
23
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. ( 26344868 )
2015
24
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. ( 25836376 )
2015
25
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. ( 25188119 )
2014
26
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. ( 25041016 )
2014
27
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. ( 25102053 )
2014
28
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. ( 24018821 )
2013
29
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. ( 24122204 )
2013
30
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. ( 23052766 )
2013
31
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. ( 23188705 )
2013
32
Development of a community-based approach to opisthorchiasis control. ( 24377646 )
2013
33
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. ( 24516289 )
2013
34
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. ( 24349600 )
2013
35
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. ( 23717698 )
2013
36
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. ( 24055716 )
2013
37
Does a combination of opisthorchiasis and ethyl alcohol consumption enhance early cholangiofibrosis, the risk of cholangiocarcinoma? ( 23807659 )
2013
38
Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. ( 21704729 )
2012
39
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. ( 21843654 )
2012
40
Discovery of human opisthorchiasis: a mysterious history. ( 21867771 )
2012
41
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. ( 21763455 )
2012
42
A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. ( 21938537 )
2012
43
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. ( 22160279 )
2012
44
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. ( 22186974 )
2012
45
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
46
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis. ( 22327320 )
2012
47
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. ( 23480766 )
2012
48
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. ( 21704727 )
2012
49
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. ( 21704728 )
2012
50
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. ( 20446100 )
2011

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CXCL8 IL1B IL4
2 11.9 CXCL8 IL1B IL6R
3
Show member pathways
11.88 CXCL8 IL1B IL4
4
Show member pathways
11.79 CXCL8 IL1B IL4 IL6R
5 11.73 CXCL8 IL1B IL4
6 11.63 CXCL8 IL1B IL6R
7 11.57 IL1B IL4 IL6R
8
Show member pathways
11.55 IL1B IL4 IL6R
9 11.41 AFP CXCL8 IL4
10 11.23 CXCL8 IL1B IL4
11 11.06 IL1B IL4
12 11.02 IL1B IL4
13 10.98 CXCL8 IL1B IL4 IL6R
14 10.94 CXCL8 IL1B IL4
15 10.82 CXCL8 IL1B IL4
16 10.63 IL1B IL4

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AFP CXCL8 IL1B IL4 IL6R MFGE8
2 extracellular space GO:0005615 9.23 AFP CTSF CXCL8 GPT IL1B IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 9.26 IL1B IL6R
2 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.16 IL1B IL4
3 positive regulation of phagocytosis GO:0050766 8.96 IL1B MFGE8
4 positive regulation of chemokine biosynthetic process GO:0045080 8.62 IL1B IL4

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL4

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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