MCID: OPS001
MIFTS: 44

Opisthorchiasis malady

Infectious diseases, Liver diseases categories

Summaries for Opisthorchiasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by opisthorchis viverrini or opisthorchis felineus. the symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards: Opisthorchiasis, also known as infection due to cat liver fluke, is related to cholangiocarcinoma and clonorchiasis. An important gene associated with Opisthorchiasis is KRT9 (keratin 9). The drugs albendazole and praziquantel and the compounds bis(2-chloroethyl)sulfide and survanta have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes.

Wikipedia:63 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Aliases & Classifications for Opisthorchiasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

opisthorchiasis 8 42 10 44 60
infection due to cat liver fluke 42
infection due to opisthorchis 42
infection by opisthorchis 8


External Ids:

Disease Ontology8 DOID:13768
MeSH34 D009889
SNOMED-CT56 187124006, 1059007
ICD9CM27 121.0
ICD1025 B66.0

Related Diseases for Opisthorchiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.8GGT1
2clonorchiasis30.5TSPAN2, EPGN, CTSF
3liver cirrhosis29.9GPT, GGT1
4cholangitis29.9GPT, GGT1
5hepatitis b29.9GPT, GGT1
6glomerulonephritis29.9IL1B
7hepatitis10.3
8fascioliasis10.2
9hepatitis a10.1
10pancreas disease10.0GGT1
11hepatitis e10.0GPT
12thrombocytopenia10.0GPT
13nephrotic syndrome10.0IGES
14schistosomiasis10.0TSPAN2, EPGN
15graves' disease10.0IGES
16hyperuricemia10.0GGT1, GPT
17biliary atresia10.0GPT, GGT1
18acute myocardial infarction10.0IGES
19hypercholesterolemia10.0GGT1, GPT
20myocardial infarction10.0IGES
21obstructive jaundice10.0GGT1, GPT
22choledocholithiasis10.0GGT1, GPT
23coronary heart disease10.0GGT1
24portal hypertension10.0GGT1, GPT
25bilirubin metabolic disorder10.0GPT, GGT1
26hypertriglyceridemia10.0GPT, GGT1
27muckle-wells syndrome10.0IL1B
28respiratory failure10.0IL1B
29acute pancreatitis10.0GPT, IL8
30hypersensitivity reaction type ii disease10.0IL1B
31eosinophilia10.0IGES, IL8
32bronchiectasis10.0IL8, IGES
33cystic fibrosis10.0IGES, IL8
34pulmonary eosinophilia10.0GGT1, IL8
35alcoholic hepatitis10.0GGT1, GPT, IL8
36alcoholic liver cirrhosis10.0GGT1, IL8, GPT
37gingivitis10.0IL1B
38primary sclerosing cholangitis10.0GPT, GGT1
39vernal keratoconjunctivitis10.0IL8, IGES
40otitis media10.0IL1B, IGES
41mastitis10.0IL8, IL1B
42bacterial meningitis10.0IL1B, IL8
43arthritis10.0IL1B, IL8
44cork-handlers' disease10.0IL1B, IL8, IGES
45viral infectious disease10.0IGES, IL1B, GGT1, GPT, IL8
46primary biliary cirrhosis9.9
47paragonimiasis9.9
48fasciolopsiasis9.9
49duodenitis9.9
50cholestasis9.9

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to opisthorchiasis

Clinical Features for Opisthorchiasis

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Drugs & Therapeutics for Opisthorchiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Opisthorchiasis

Drug clinical trials:

Search ClinicalTrials for Opisthorchiasis

Search NIH Clinical Center for Opisthorchiasis

Search CenterWatch for Opisthorchiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Opisthorchiasis

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Anatomical Context for Opisthorchiasis

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32MalaCards
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MalaCards organs/tissues related to Opisthorchiasis:

32
Liver, Pancreas, Testes

Animal Models for Opisthorchiasis or affiliated genes

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Publications for Opisthorchiasis

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Sources:
50PubMed
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Articles related to Opisthorchiasis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. (23717698)
2013
2
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. (21704727)
2012
3
Discovery of human opisthorchiasis: a mysterious history. (21867771)
2012
4
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. (21704728)
2012
5
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. (21893213)
2012
6
Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression. (20578454)
2009
7
Complete Sequencing of the Mitochondrial Genome of Opisthorchis felineus, Causative Agent of Opisthorchiasis. (22649593)
2009
8
Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. (18725803)
2008
9
Opisthorchis viverrini: identification of a glycine-tyrosine rich eggshell protein and its potential as a diagnostic tool for human opisthorchiasis. (16876169)
2006
10
Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). (15948244)
2005
11
Analysis of a complex of biochemical parameters of hepatic functions in opisthorchiasis]. (16445232)
2005
12
Psoriasis associated with opisthorchiasis under conditions of anthelmintic therapy. (15452616)
2004
13
Opisthorchis viverrini and opisthorchiasis: The 21st Century review. Proceedings of the Congress of Opisthorchiasis and Cholangiocarcinoma. May 28-30, 2002. Khon Kaen, Thailand. (14763464)
2003
14
Pathobiology of opisthorchiasis: an update. (14611875)
2003
15
Opisthorchiasis control in Thailand. (14611877)
2003
16
Opisthorchis viverrini and opisthorchiasis: a historical review and future perspective. (14611871)
2003
17
Affinity purified oval antigen for diagnosis of Opisthorchiasis viverrini. (12009074)
2001
18
Evaluation of Bithynia funiculata snail antigens by ELISA-serodiagnosis of human opisthorchiasis. (9561614)
1997
19
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini. (8896890)
1996
20
Serum antibody responses in opisthorchiasis. (8550296)
1995
21
Clonorchiasis/opisthorchiasis in Malaysians case reports and review. (7565193)
1995
22
Opisthorchiasis control in northeast Thailand: proposal for a new approach. (8087151)
1994
23
Changes in serum antibodies to Opisthorchis viverrini in humans and hamsters following treatment of opisthorchiasis. (7872997)
1994
24
Possible protective immunity in human opisthorchiasis. (7526321)
1994
25
Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma. (1653472)
1991
26
Immunodiagnosis of opisthorchiasis. (1822882)
1991
27
Ultrasonographic study of the biliary system in opisthorchiasis patients after treatment with praziquantel. (2672363)
1989
28
Biliary bile acids and lipids composition in Opisthorchiasis viverrini. (3241137)
1988
29
Control of opisthorchiasis through community participation. (15462869)
1987
30
High urinary excretion of nitrate and N-nitrosoproline in opisthorchiasis subjects. (3679440)
1987
31
Clinical field trial of praziquantel in opisthorchiasis in Nong Rangya Village, Khon Kaen Province, Thailand. (3738609)
1986
32
Computed tomography in opisthorchiasis. (6529907)
1984
33
Roentgenographically controlled healing of gallbladder lesions in opisthorchiasis after praziquantel treatment. (6542387)
1984
34
Therapeutic results in opisthorchiasis with praziquantel in a reinfection-free environment in France. (6542388)
1984
35
Some immunological aspects of opisthorchiasis. (6542385)
1984
36
Clonorchiasis/opisthorchiasis in South Carolina. (6572766)
1983
37
Study on serum bile acids in opisthorchiasis in Thailand. (6644209)
1983
38
Clinical and laboratory evaluation of praziquantel in opisthorchiasis. (6658504)
1983
39
Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. (6983303)
1982
40
Field trial of praziquantel in human opisthorchiasis in Thailand. (7344110)
1981
41
Praziquantel in clonorchiasis and opisthorchiasis. (7345688)
1981
42
Studies on the chemotherapy of human opisthorchiasis in Thailand: I. Clinical trial of praziquantel. (7013095)
1980
43
Opisthorchiasis: a clinicopathologic study of 154 autopsy cases. (212836)
1978
44
Carcinoma of the cystic duct associated with opisthorchiasis. (1030849)
1976
45
A clinical trial of oral dehydroemetine in opisthorchiasis. (4617315)
1974
46
Serum vitamin B 12 level in patients with amoebic liver abscess, opisthorchiasis and hookworm infections. (5112336)
1971
47
Pathology of liver and pancreas in opisthorchiasis noverca in dogs and pigs. (5103963)
1971
48
Opisthorchiasis in Thailand. (14399806)
1960
49
Retention cyst of liver caused by opisthorchiasis associated with carcinoma; case report. (14361385)
1955
50
Observations on two cases of opisthorchiasis in Thailand. (13105258)
1953

Genetic Variations for Opisthorchiasis

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Expression for genes affiliated with Opisthorchiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for genes affiliated with Opisthorchiasis

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Compounds for genes affiliated with Opisthorchiasis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Opisthorchiasis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide4410.3IL1B, IL8
2survanta4410.3IL1B, IL8
3aminooxyacetic acid44 2811.3GPT, GGT1
4echinacea4410.3IL8, IL1B
5tlck4410.2IL1B, IL8
6muramyl dipeptide44 2811.2IL8, IL1B
7lxa44410.2IL8, IL1B
8monosodium urate4410.2IL8, IL1B
9aminopyrine4410.2GGT1, GPT
10taurine chloramine4410.2IL1B, IL8
11toxin-14410.2IL8, IL1B
12hbd24410.2IL8, IL1B
13mip 1alpha4410.1IL1B, IL8
14gold sodium thiomalate4410.1IL8, IL1B
15hcec4410.1IL8, GGT1
16nash4410.1GPT, GGT1
17nevirapine44 49 1112.0GGT1, GPT
18neopterin4410.0GPT, IL1B, IL8
19sevoflurane44 1111.0GPT, GGT1
20pentoxifylline44 1110.9GGT1, IL1B, IL8
215 aminosalicylic acid449.9IL1B, IL8
22flagellin44 2810.9IL1B, IL8
23troglitazone44 28 59 1112.9GPT, IL1B, IL8
24clarithromycin44 1110.8GPT, IL8
25phosphorus449.8INTS9, GPT, GGT1
26vitamin-e449.7IGES, GPT, GGT1
27hyaluronic acid44 2410.7GGT1, GPT, IL1B, IL8
28n acetylcysteine449.7IL8, IL1B, GPT, GGT1
29il-12449.6IL1B, IL8
30lactate449.3GGT1, GPT, IL8, IGES

GO Terms for genes affiliated with Opisthorchiasis

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16Gene Ontology
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Biological processes related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid transportGO:0068698.7OSBP2, OSBPL8, OSBPL7

Molecular functions related to Opisthorchiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154858.7OSBP2, OSBPL8, OSBPL7

Products for genes affiliated with Opisthorchiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Opisthorchiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet