MCID: OPS001
MIFTS: 36

Opisthorchiasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Opisthorchiasis

Aliases & Descriptions for Opisthorchiasis:

Name: Opisthorchiasis 12 50 52 42 14 69
Infection Due to Cat Liver Fluke 50
Infection Due to Opisthorchis 50
Infection by Opisthorchis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13768
ICD10 33 B66.0
ICD9CM 35 121.0
MeSH 42 D009889
SNOMED-CT 64 1059007 187124006
UMLS 69 C0029106

Summaries for Opisthorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.

MalaCards based summary : Opisthorchiasis, also known as infection due to cat liver fluke, is related to conidiobolomycosis and psychotic disorder. An important gene associated with Opisthorchiasis is MFGE8 (Milk Fat Globule-EGF Factor 8 Protein), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 71 Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically,... more...

Related Diseases for Opisthorchiasis

Diseases related to Opisthorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 conidiobolomycosis 10.1 CXCL8 IL4
2 psychotic disorder 10.1 CXCL8 IL4
3 retinal vascular disease 10.1 CXCL8 IL4
4 breast intracanalicular fibroadenoma 10.1 CXCL8 IL4
5 breast papillary carcinoma 10.1 CXCL8 IL6R
6 rosacea 10.1 GPT IL1B
7 vitreoretinopathy, neovascular inflammatory 10.1 CXCL8 IL6R
8 ileocolitis 10.1 IL1B IL4
9 clonorchiasis 10.1
10 oculomotor nerve paralysis 10.1 CXCL8 IL1B
11 megaloblastic anemia 10.1 GPT IL1B
12 common peroneal nerve lesion 10.1 CXCL8 IL1B
13 histoplasmosis retinitis 10.1 IL1B IL4
14 childhood electroclinical syndrome 10.1 CXCL8 IL1B
15 lacrimal apparatus disease 10.0 CXCL8 IL1B
16 hepatitis 10.0
17 amyotrophic lateral sclerosis type 14 10.0 CXCL8 IL1B
18 parkinson disease 11 10.0 CXCL8 IL1B
19 bullous retinoschisis 10.0 CXCL8 IL1B
20 mikulicz disease 10.0 IL1B IL4
21 carbuncle 10.0 CXCL8 IL1B
22 larynx leiomyoma 10.0 CXCL8 IL1B
23 plantar wart 10.0 CTSF CXCL8
24 senile reticular retinal degeneration 10.0 CXCL8 IL1B
25 coenurosis 10.0 IL1B IL4
26 hidradenitis 9.9 CXCL8 IL1B
27 autosomal recessive type iv ehlers-danlos syndrome 9.9 CXCL8 IL1B IL4
28 nasopharyngitis 9.9 CXCL8 IL1B IL4
29 balkan nephropathy 9.9 CXCL8 IL1B IL4
30 colon adenocarcinoma 9.9 CXCL8 IL1B IL4
31 blue toe syndrome 9.9 CXCL8 IL1B IL4
32 parasitic protozoa infectious disease 9.9 CXCL8 IL1B IL4
33 keratomalacia 9.9 CXCL8 IL1B IL4
34 gonococcal endophthalmia 9.9 IL1B IL4
35 spontaneous ocular nystagmus 9.9 CXCL8 IL1B IL4
36 pigmentation disease 9.9 CXCL8 IL1B IL4
37 bare lymphocyte syndrome, type i 9.9 CXCL8 IL1B IL4
38 acquired thrombocytopenia 9.9 CXCL8 IL1B
39 bone angioendothelial sarcoma 9.9 CXCL8 IL1B IL4
40 acute chest syndrome 9.9 CXCL8 IL1B IL4
41 nervous system cancer 9.9 CXCL8 IL1B IL4
42 blepharochalasis 9.9 AFP CXCL8 IL1B
43 spinal multifocal clear cell meningioma 9.9 AFP CXCL8 IL1B
44 collagenous colitis 9.9 CXCL8 IL1B IL4
45 thymus adenosquamous carcinoma 9.9 CXCL8 IL1B IL4
46 subcorneal pustular dermatosis 9.9 CXCL8 IL1B IL4
47 fascioliasis 9.9
48 childhood malignant hemangiopericytoma 9.9 AFP CXCL8 IL1B
49 glycogen storage disease ix 9.9 CXCL8 IL1B IL4
50 ectodermal dysplasia bartalos type 9.8 IL1B IL4

Graphical network of the top 20 diseases related to Opisthorchiasis:



Diseases related to Opisthorchiasis

Symptoms & Phenotypes for Opisthorchiasis

Drugs & Therapeutics for Opisthorchiasis

Search Clinical Trials , NIH Clinical Center for Opisthorchiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: opisthorchiasis

Genetic Tests for Opisthorchiasis

Anatomical Context for Opisthorchiasis

MalaCards organs/tissues related to Opisthorchiasis:

39
Liver, Pancreas, Testes

Publications for Opisthorchiasis

Articles related to Opisthorchiasis:

(show top 50) (show all 166)
id Title Authors Year
1
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. ( 26817235 )
2016
2
Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area. ( 27482325 )
2016
3
Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. ( 27576001 )
2016
4
Development of an ELISA using anti-idiotypic antibody for diagnosis of opisthorchiasis. ( 27507639 )
2016
5
The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. ( 27890720 )
2016
6
Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. ( 27140305 )
2016
7
Ultrasonographic features of hepatobiliary in opisthorchiasis. ( 27956092 )
2016
8
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? ( 27919744 )
2016
9
Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations. ( 27939972 )
2016
10
Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. ( 25836376 )
2015
11
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. ( 26312563 )
2015
12
Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD. ( 26602874 )
2015
13
Immunodiagnosis of opisthorchiasis using parasite cathepsin F. ( 26344868 )
2015
14
Cholangiocarcinoma and opisthorchiasis in Northeast Thailand: raw fish intake may not be the sole cause. ( 26108023 )
2015
15
Opisthorchiasis: an overlooked danger. ( 25836334 )
2015
16
Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis. ( 25877389 )
2015
17
Community-Based Health Education and Communication Model Development for Opisthorchiasis Prevention in a High Risk Area, Khon Kaen Province, Thailand. ( 26625799 )
2015
18
Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. ( 26485024 )
2015
19
An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand. ( 25041016 )
2014
20
Toward integrated opisthorchiasis control in Northeast Thailand: The Lawa project. ( 25102053 )
2014
21
Infectious Diseases and Tropical Disease Pathology: SY16-3 OPISTHORCHIASIS: FROM PATHOGENESIS TO CONTROL. ( 25188119 )
2014
22
Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. ( 23052766 )
2013
23
High prevalence of haplorchiasis in Nan and Lampang provinces, Thailand, proven by adult worm recovery from suspected opisthorchiasis cases. ( 24516289 )
2013
24
Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. ( 24349600 )
2013
25
Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. ( 24018821 )
2013
26
Development of a community-based approach to opisthorchiasis control. ( 24377646 )
2013
27
Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. ( 24055716 )
2013
28
Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma. ( 24122204 )
2013
29
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. ( 23717698 )
2013
30
Does a combination of opisthorchiasis and ethyl alcohol consumption enhance early cholangiofibrosis, the risk of cholangiocarcinoma? ( 23807659 )
2013
31
Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. ( 23188705 )
2013
32
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. ( 21704728 )
2012
33
Discovery of human opisthorchiasis: a mysterious history. ( 21867771 )
2012
34
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. ( 22186974 )
2012
35
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
36
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. ( 21704727 )
2012
37
Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. ( 22160279 )
2012
38
High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. ( 21843654 )
2012
39
Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. ( 21704729 )
2012
40
Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. ( 23480766 )
2012
41
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. ( 21763455 )
2012
42
A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. ( 21938537 )
2012
43
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis. ( 22327320 )
2012
44
Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. ( 20655862 )
2011
45
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. ( 20446100 )
2011
46
Histopathological diagnosis of opisthorchiasis in an immigrant. ( 20889856 )
2010
47
Iso-electricfocusing of Bithynia snail antigens for IgG- and IgG(1-4)-ELISA detection of human opisthorchiasis. ( 21073055 )
2010
48
Opisthorchis viverrini: evaluation of 28 kDa glutathione S-transferase as diagnostic tool in human opisthorchiasis. ( 20096257 )
2010
49
Opisthorchiasis mimicking primary biliary cirrhosis as an indication for liver transplantation. ( 19329217 )
2009
50
[Dynamics of pro-and anti-inflammatory cytokines at patients with combination of chronic opisthorchiasis with Helicobacter pylori-associated gastritis]. ( 19551959 )
2009

Variations for Opisthorchiasis

Expression for Opisthorchiasis

Search GEO for disease gene expression data for Opisthorchiasis.

Pathways for Opisthorchiasis

Pathways related to Opisthorchiasis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CXCL8 IL1B IL4
2 11.9 CXCL8 IL1B IL6R
3
Show member pathways
11.88 CXCL8 IL1B IL4
4
Show member pathways
11.79 CXCL8 IL1B IL4 IL6R
5 11.71 CXCL8 IL1B IL4
6 11.63 CXCL8 IL1B IL6R
7
Show member pathways
11.59 IL1B IL4 IL6R
8 11.53 IL1B IL4 IL6R
9 11.41 AFP CXCL8 IL4
10 11.23 CXCL8 IL1B IL4
11 11.06 IL1B IL4
12 11.02 IL1B IL4
13 10.98 CXCL8 IL1B IL4 IL6R
14 10.94 CXCL8 IL1B IL4
15 10.82 CXCL8 IL1B IL4
16 10.65 IL1B IL4

GO Terms for Opisthorchiasis

Cellular components related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AFP CXCL8 IL1B IL4 IL6R MFGE8
2 extracellular space GO:0005615 9.23 AFP CTSF CXCL8 GPT IL1B IL4

Biological processes related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 9.26 IL1B IL6R
2 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.16 IL1B IL4
3 positive regulation of phagocytosis GO:0050766 8.96 IL1B MFGE8
4 positive regulation of chemokine biosynthetic process GO:0045080 8.62 IL1B IL4

Molecular functions related to Opisthorchiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL4

Sources for Opisthorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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