MCID: OPP004
MIFTS: 47

Oppositional Defiant Disorder

Categories: Mental diseases

Aliases & Classifications for Oppositional Defiant Disorder

MalaCards integrated aliases for Oppositional Defiant Disorder:

Name: Oppositional Defiant Disorder 12 72 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050856
ICD10 32 F91.3
UMLS 69 C0029121

Summaries for Oppositional Defiant Disorder

MalaCards based summary : Oppositional Defiant Disorder is related to separation anxiety disorder and traumatic brain injury, and has symptoms including pseudobulbar behavioral symptoms, restlessness and personality changes. An important gene associated with Oppositional Defiant Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Transmission across Chemical Synapses and Circadian entrainment. The drugs Dopamine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Oppositional defiant disorder (ODD) is defined by the DSM-5 as \"a pattern of angry/irritable mood,... more...

Related Diseases for Oppositional Defiant Disorder

Diseases related to Oppositional Defiant Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 separation anxiety disorder 30.3 DRD4 SLC6A3
2 traumatic brain injury 29.8 COMT DRD2
3 brain injury 29.6 COMT DRD2
4 tic disorder 29.4 DRD2 DRD4 SLC6A3 TPH2
5 stuttering 29.4 DBH DRD2 SLC6A3
6 generalized anxiety disorder 29.4 DRD2 MAOA SLC6A2 SLC6A4
7 borderline personality disorder 29.1 COMT MAOA SLC6A4 TPH2
8 anxiety 29.1 COMT MAOA SLC6A2 SLC6A3 SLC6A4 TPH2
9 conduct disorder 28.8 COMT DBH DRD2 DRD4 MAOA SLC6A3
10 autism 28.5 COMT DRD2 DRD4 MAOA SLC6A4 TPH2
11 gilles de la tourette syndrome 28.4 COMT DBH DRD2 DRD4 SLC6A3
12 autism spectrum disorder 28.0 COMT DRD2 DRD4 MAOA SLC6A3 SLC6A4
13 personality disorder 27.8 COMT DRD2 DRD4 MAOA SLC6A3 SLC6A4
14 attention deficit-hyperactivity disorder 27.7 COMT DBH DRD2 DRD4 MAOA SLC6A2
15 alcohol dependence 26.9 COMT DBH DRD2 DRD4 MAOA SLC6A3
16 bipolar disorder 26.5 COMT DBH DRD2 DRD4 MAOA SLC6A2
17 dependent personality disorder 10.3 DRD4 MAOA
18 amphetamine abuse 10.3 SLC6A2 SLC6A3
19 atypical depressive disorder 10.3 MAOA SLC6A4
20 dysthymic disorder 10.2 MAOA SLC6A4
21 delusional disorder 10.2 DRD2 DRD4
22 striatonigral degeneration 10.2 DRD2 SLC6A3
23 kleptomania 10.2 MAOA SLC6A4
24 impulse control disorder 10.2 DRD2 DRD4
25 aging 10.2
26 alcohol use disorder 10.2 DRD2 SLC6A4
27 phobia, specific 10.1 COMT MAOA
28 periodic limb movement disorder 10.1 DRD2 SLC6A4
29 bruxism 10.1 DRD2 SLC6A4
30 dystonia 1, torsion, autosomal dominant 10.0 COMT MAOA
31 heroin dependence 10.0 DRD2 DRD4 SLC6A3
32 schizophreniform disorder 10.0 COMT DRD2
33 kleine-levin hibernation syndrome 10.0 COMT SLC6A3
34 polysubstance abuse 10.0 COMT DRD2
35 tardive dyskinesia 10.0 COMT DRD2
36 orofacial cleft 10.0 DRD2 DRD4 SLC6A3
37 central nervous system disease 10.0 SLC6A2 SLC6A3 SLC6A4
38 agoraphobia 10.0 MAOA SLC6A2 SLC6A4
39 serotonin syndrome 10.0 MAOA SLC6A4
40 alcohol-induced mental disorder 10.0 DRD2 SLC6A3 SLC6A4
41 alcoholic psychosis 10.0 DRD2 SLC6A3 SLC6A4
42 blood group, i system 9.9
43 reading disorder 9.9
44 hematohidrosis 9.9
45 opioid addiction 9.9 COMT DRD2
46 autonomic nervous system disease 9.9 DBH DRD4
47 opiate dependence 9.9 DRD2 SLC6A4
48 migraine without aura 9.9 DRD2 DRD4 SLC6A4
49 social phobia 9.9 DRD2 MAOA SLC6A4
50 alcohol abuse 9.9 DRD2 DRD4 SLC6A4

Graphical network of the top 20 diseases related to Oppositional Defiant Disorder:



Diseases related to Oppositional Defiant Disorder

Symptoms & Phenotypes for Oppositional Defiant Disorder

UMLS symptoms related to Oppositional Defiant Disorder:


pseudobulbar behavioral symptoms, restlessness, personality changes, photophobia, sleep disturbances

MGI Mouse Phenotypes related to Oppositional Defiant Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 SLC6A3 COMT SLC6A4 DBH TPH2 DRD2
2 homeostasis/metabolism MP:0005376 9.91 SLC6A3 COMT SLC6A4 DBH TPH2 DRD2
3 cardiovascular system MP:0005385 9.87 SLC6A2 COMT SLC6A4 DBH TPH2 DRD2
4 integument MP:0010771 9.63 SLC6A2 SLC6A3 SLC6A4 DBH TPH2 DRD2
5 nervous system MP:0003631 9.61 SLC6A3 COMT SLC6A4 DBH TPH2 DRD2
6 taste/olfaction MP:0005394 8.8 SLC6A3 TPH2 DRD2

Drugs & Therapeutics for Oppositional Defiant Disorder

Drugs for Oppositional Defiant Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
4
Methylphenidate Approved, Investigational Phase 4,Phase 2,Phase 3 20748-11-2, 113-45-1 4158
5
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
6
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
7
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
8
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 3007 5826
9
Ziprasidone Approved Phase 4,Phase 2 146939-27-7 60854
10
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
11
Serotonin Phase 4,Phase 3,Phase 2,Phase 1 50-67-9 5202
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
13 Central Nervous System Stimulants Phase 4,Phase 2,Phase 3
14 Serotonin Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Serotonin Antagonists Phase 4,Phase 3,Phase 2
16 GABA Agents Phase 4
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Tranquilizing Agents Phase 4,Phase 3,Phase 2
19 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
20 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Dopamine Antagonists Phase 4,Phase 3,Phase 2
22 Dopamine Uptake Inhibitors Phase 4,Phase 2,Phase 3
23 Anticonvulsants Phase 4
24 Antimanic Agents Phase 4
25 Psychotropic Drugs Phase 4,Phase 3,Phase 2
26 Antipsychotic Agents Phase 4,Phase 3,Phase 2
27 insulin Phase 4
28 Adrenergic Agents Phase 4,Phase 3
29 Adrenergic Agonists Phase 4
30 Adrenergic alpha-2 Receptor Agonists Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Serotonin Uptake Inhibitors Phase 4
33 Gastrointestinal Agents Phase 4
34 Peripheral Nervous System Agents Phase 4
35 Antiemetics Phase 4
36 Antihypertensive Agents Phase 4
37 Insulin, Globin Zinc Phase 4
38 Atomoxetine Hydrochloride Phase 4,Phase 3
39 Autonomic Agents Phase 4
40
Ethanol Approved Phase 2, Phase 3 64-17-5 702
41
2-Phenylethanol Experimental Phase 2, Phase 3 60-12-8 6054
42 Disinfectants Phase 2, Phase 3
43 Pharmaceutical Solutions Phase 3,Phase 2
44 Anti-Infective Agents Phase 2, Phase 3
45 Anti-Infective Agents, Local Phase 2, Phase 3
46
Oxytocin Approved, Vet_approved Phase 2 50-56-6 53477758 439302
47 Quetiapine Fumarate Phase 2 111974-72-2
48 Oxytocics Phase 2
49 Brexpiprazole Approved, Investigational Phase 1 913611-97-9 11978813
50 Dopamine agonists Phase 1

Interventional clinical trials:

(show top 50) (show all 57)

# Name Status NCT ID Phase Drugs
1 Methylphenidate vs. Risperidone for the Treatment of Children and Adolescents With ADHD and Disruptive Disorders Unknown status NCT02063945 Phase 4 Methylphenidate;Risperidone
2 Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study) Unknown status NCT00794625 Phase 4 Valproate;Risperidone;Placebo;Stimulant medication
3 Comparison of Atomoxetine Versus Placebo in Children and Adolescents With ADHD and Comorbid ODD in Germany Completed NCT00406354 Phase 4 Atomoxetine;Placebo
4 Medication Strategies for Treating Aggressive Behavior in Youth With Attention Deficit Hyperactivity Disorder Completed NCT00228046 Phase 4 Divalproex Sodium;Methylphenidate;Dextroamphetamine;Mixed Amphetamine Salts
5 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
6 Metabolic Effects of Antipsychotics in Children Completed NCT00205699 Phase 4 risperidone;olanzapine;aripiprazole
7 A Randomized, Double-Blind Comparison of Placebo and Atomoxetine Hydrochloride Given Once a Day in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD) Completed NCT00190775 Phase 4 Atomoxetine Hydrochloride;Placebo
8 Effects of Evening Dose of Immediate Release Methylphenidate on Sleep in Children With ADHD Recruiting NCT02638168 Phase 4 Immediate Release Methylphenidate;Placebo
9 Methylphenidate in Adults With Attention Deficit/Hyperactivity Disorder Recruiting NCT02951754 Phase 4 Immediate-release Methylphenidate
10 An Italian Study of the Efficacy of Atomoxetine in the Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) and Comorbid Oppositional Defiant Disorder (ODD). Completed NCT00192023 Phase 3 atomoxetine 0.5 mg/kg/day;placebo;atomoxetine 1.2 mg/kg/day;atomoxetine 1.2-1.4 mg/kg/day
11 Comparison of Atomoxetine and Placebo in Children and Adolescents With ADHD and ODD Completed NCT00191698 Phase 3 atomoxetine hydrochloride;placebo
12 Treatment of Children With Peer Related Aggressive Behavior Completed NCT01406067 Phase 3
13 Strongest Families Ontario (Formerly the Family Help Program) Completed NCT01473511 Phase 3
14 A Study of the Safety and Effectiveness of Risperidone Versus Placebo for the Treatment of Conduct Disorder in Children With Mild, Moderate, or Borderline Mental Retardation Completed NCT00266552 Phase 3 risperidone
15 A Study of the Safety and Effectiveness of Risperidone for the Treatment of Conduct Disorder and Other Disruptive Behavior Disorders in Children Ages 5 to 12 With Mild, Moderate, or Borderline Mental Retardation Completed NCT00250354 Phase 3 Risperidone oral solution
16 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
17 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Completed NCT00922636 Phase 2, Phase 3 LY2216684;Methylphenidate;Placebo (tablet);Placebo (capsule)
18 Parent Training to Promote Early Identification and Treatment of Childhood Behavioral Disorders Completed NCT00402857 Phase 3
19 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Terminated NCT00965419 Phase 2, Phase 3 LY2216684
20 Ziprasidone for Severe Conduct and Other Disruptive Behavior Disorders Completed NCT00676429 Phase 2 Ziprasidone Hydrochloride;Placebo
21 Home Based Treatment for Drug Use in Early Adolescents Completed NCT00280228 Phase 2
22 Quetiapine and Concerta in the Treatment for ADHD and Aggressive Behavior. Completed NCT00550147 Phase 2 Oros Methylphenidate;quetiapine
23 Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders Recruiting NCT02824627 Phase 2 Oxytocin;Placebo
24 Treatment of Conduct Problems and Depression Unknown status NCT01267773 Phase 1
25 Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorders Recruiting NCT03292848 Phase 1 Brexpiprazole
26 Prevention of Oppositional Defiant and Conduct Disorders in Preschool Children Unknown status NCT00189189
27 Guided Self-Help for Parents of Children With Externalizing Problem Behavior Unknown status NCT01350986
28 Epidemiological Study for Psychiatric Disorder Among Children and Adolescents Unknown status NCT02707848
29 Explore the Association Between Neuropsychological Functions and ADHD Diagnosis and Comorbid Using Longitudinal Study in Preschool Children Unknown status NCT02433145
30 Toolkit for School Behavior Modification in Children With Attention-Deficit/Hyperactivity Disorder (ADHD) Unknown status NCT01330849
31 Better Understand Children and Adolescents' Intrafamilial Oppositional Defiant Disorder Completed NCT03447535
32 Comparison of Two Psychosocial Therapies for Treating Children With Oppositional-Defiant Disorder Completed NCT00510120
33 Multi-Family Group Therapy for Reducing Behavioral Difficulties in Youth Completed NCT00404911
34 On-line Treatment for Conduct Problems Completed NCT01822392
35 Behavioral Treatment for Children With Conduct Problems and Callous-Unemotional Traits Completed NCT01362946
36 Supplements and Social Skills Intervention Study Completed NCT00819429
37 Evaluating the Feasibility of Internet-delivered PCIT Completed NCT03260725
38 Resources to Enhance the Adjustment of Children (REACH) Completed NCT00820001
39 The Effectiveness of Parent-Child Interaction Therapy (PCIT) Completed NCT01085305
40 School-Based Mental Health Services for Urban Children Completed NCT00612690
41 Correlating Real and Virtual World Behavioral Fluctuations in Adolescence Completed NCT02281825
42 Brain Changes in Children and Adolescents With Behavioral Problems Completed NCT00104039
43 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551
44 Manville Moves: an Exercise Intervention for Behavioral Regulation Among Children With Behavioral Health Challenges Completed NCT02766101
45 Randomized Feasibility Trial of Mind My Mind Completed NCT03448809
46 Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) Completed NCT00579267
47 Parent Training and Emotion Coaching for Children With Limited Prosocial Emotions Recruiting NCT02409992
48 Treatment of Children With Peer Related Aggressive Behavior (ScouT) Recruiting NCT02143427
49 Study of Cognition and Control in Youths Recruiting NCT03393390
50 Arousal-Biofeedback for the Treatment of Aggressive Behavior in Children and Adolescents Recruiting NCT02485587

Search NIH Clinical Center for Oppositional Defiant Disorder

Genetic Tests for Oppositional Defiant Disorder

Anatomical Context for Oppositional Defiant Disorder

MalaCards organs/tissues related to Oppositional Defiant Disorder:

38
Brain, Testes, Cortex, Eye

Publications for Oppositional Defiant Disorder

Articles related to Oppositional Defiant Disorder:

(show top 50) (show all 140)
# Title Authors Year
1
Social skills training and play group intervention for children with oppositional-defiant disorders/conduct disorder: Mediating mechanisms in a head-to-head comparison. ( 29347904 )
2018
2
Predictors of Partial Hospital Readmission for Young Children with Oppositional Defiant Disorder. ( 29164350 )
2017
3
Executive Function Features in Drug-naive Children with Oppositional Defiant Disorder. ( 28955142 )
2017
4
Children with ADHD and symptoms of oppositional defiant disorder improved in behavior when treated with methylphenidate and adjuvant risperidone, though weight gain was also observed - Results from a randomized, double-blind, placebo-controlled clinical trial. ( 28213188 )
2017
5
Boys with Oppositional Defiant Disorder/Conduct Disorder Show Impaired Adaptation During Stress: An Executive Functioning Study. ( 28755013 )
2017
6
Structural Brain Abnormalities of Attention-Deficit/Hyperactivity Disorder With Oppositional Defiant Disorder. ( 28911901 )
2017
7
Age 4 Predictors of Oppositional Defiant Disorder in Early Grammar School. ( 28278601 )
2017
8
Oppositional defiant disorder: current insight. ( 29238235 )
2017
9
Testing Multiple Conceptualizations of Oppositional Defiant Disorder in Youth. ( 28287828 )
2017
10
The Mutual Effect of Marital Quality and Parenting Stress on Child and Parent Depressive Symptoms in Families of Children with Oppositional Defiant Disorder. ( 29104548 )
2017
11
Parental involvement as an etiological moderator of middle childhood oppositional defiant disorder. ( 28263622 )
2017
12
Comparing the characteristics and outcomes of parent- and teacher-reported oppositional defiant disorder: findings from a national sample. ( 29230806 )
2017
13
Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology. ( 28059443 )
2017
14
A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth With Attention-Deficit/Hyperactivity Disorder Comorbid With Oppositional Defiant Disorder and Aggression. ( 28806385 )
2017
15
The Possible Effect of Methylphenidate Treatment on Empathy in Children Diagnosed with Attention-Deficit/Hyperactivity Disorder, Both With and Without Comorbid Oppositional Defiant Disorder. ( 28398816 )
2017
16
Effect of Methylphenidate on Emotional Dysregulation in Children With Attention-Deficit/Hyperactivity Disorder + Oppositional Defiant Disorder/Conduct Disorder. ( 28225747 )
2017
17
Family and Individual Risk and Protective Factors of Depression among Chinese Migrant Children with Oppositional Defiant Disorder Symptoms. ( 28421024 )
2017
18
Multi-Level Family Factors and Affective and Behavioral Symptoms of Oppositional Defiant Disorder in Chinese Children. ( 28713321 )
2017
19
Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms. ( 28573761 )
2017
20
Risk factors for comorbid oppositional defiant disorder in attention-deficit/hyperactivity disorder. ( 28283834 )
2017
21
Neurobiological stress responses predict aggression in boys with oppositional defiant disorder/conduct disorder: a 1-year follow-up intervention study. ( 28181041 )
2017
22
Is emotional dysregulation a risk indicator for auto-aggression behaviors in adolescents with oppositional defiant disorder? ( 27764737 )
2017
23
The Characteristics and Age Effects of Emotional Lability in ADHD Children With and Without Oppositional Defiant Disorder. ( 29224418 )
2017
24
Memory consolidation of socially relevant stimuli during sleep in healthy children and children with attention-deficit/hyperactivity disorder and oppositional defiant disorder: What you can see in their eyes. ( 28049026 )
2016
25
A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account. ( 26846227 )
2016
26
Emotion Regulation Difficulties in Boys with Oppositional Defiant Disorder/Conduct Disorder and the Relation with Comorbid Autism Traits and Attention Deficit Traits. ( 27420110 )
2016
27
Factors related to the comorbidity between oppositional defiant disorder and anxiety disorders in preschool children. ( 27575516 )
2016
28
Callous unemotional traits, autism spectrum disorder symptoms and empathy in boys with oppositional defiant disorder or conduct disorder. ( 27575651 )
2016
29
The Reciprocal Influence of Callous-Unemotional Traits, Oppositional Defiant Disorder and Parenting Practices in Preschoolers. ( 27013514 )
2016
30
Preschool Oppositional Defiant Disorder: A Disorder of Negative Affect, Surgency, and Disagreeableness. ( 27768388 )
2016
31
Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population. ( 27871272 )
2016
32
The Longitudinal Effects of Oppositional Defiant Disorder Symptoms on Academic and Occupational Functioning in the Transition to Young Adulthood. ( 27469319 )
2016
33
Common Questions About Oppositional Defiant Disorder. ( 27035043 )
2016
34
Early development of comorbidity between symptoms of attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). ( 26854502 )
2016
35
Predicting Depression and Anxiety from Oppositional Defiant Disorder Symptoms in Elementary School-Age Girls and Boys with Conduct Problems. ( 27209374 )
2016
36
Emotional Abilities in Children with Oppositional Defiant Disorder (ODD): Impairments in Perspective-Taking and Understanding Mixed Emotions are Associated with High Callous-Unemotional Traits. ( 27100725 )
2016
37
Child Personality Accounts for Oppositional Defiant Disorder Comorbidity Patterns. ( 27233508 )
2016
38
Is Emotional Lability Distinct From "Angry/Irritable Mood," "Negative Affect," or Other Subdimensions of Oppositional Defiant Disorder in Children With ADHD? ( 26842831 )
2016
39
Trait and State Variance in Oppositional Defiant Disorder Symptoms: A Multi-Source Investigation With Spanish Children. ( 27148784 )
2016
40
The role of anxiety in cortisol stress response and cortisol recovery in boys with oppositional defiant disorder/conduct disorder. ( 27521740 )
2016
41
Emotion Socialization in the Context of Risk and Psychopathology: Maternal Emotion Coaching Predicts Better Treatment Outcomes for Emotionally Labile Children with Oppositional Defiant Disorder. ( 26848211 )
2016
42
Multiple Levels of Family Factors and Oppositional Defiant Disorder Symptoms Among Chinese Children. ( 27900762 )
2016
43
Oral health status, dental anxiety, and behavior-management problems in children with oppositional defiant disorder. ( 26707341 )
2016
44
Sarcosine treatment for oppositional defiant disorder symptoms of attention deficit hyperactivity disorder children. ( 27443598 )
2016
45
Perceived Parent-Child Relations, Conduct Problems, and Clinical Improvement Following the Treatment of Oppositional Defiant Disorder. ( 27284234 )
2016
46
Emotional Regulation and Executive Function Deficits in Unmedicated Chinese Children with Oppositional Defiant Disorder. ( 27247593 )
2016
47
Sex Differences in the Prevalence of Oppositional Defiant Disorder During Middle Childhood: a Meta-Analysis. ( 27282758 )
2016
48
Innocent or Intentional?: Interpreting Oppositional Defiant Disorder in a Preschool Mental Health Clinic. ( 27761690 )
2016
49
Maltreatment and Emotional and Behavioral Problems in Chinese Children With and Without Oppositional Defiant Disorder: The Mediating Role of the Parent-Child Relationship. ( 26811315 )
2016
50
DISC Predictive Scales (DPS): Factor Structure and Uniform Differential Item Functioning Across Gender and Three Racial/Ethnic Groups for ADHD, Conduct Disorder, and Oppositional Defiant Disorder Symptoms. ( 25774639 )
2015

Variations for Oppositional Defiant Disorder

Expression for Oppositional Defiant Disorder

Search GEO for disease gene expression data for Oppositional Defiant Disorder.

Pathways for Oppositional Defiant Disorder

Pathways related to Oppositional Defiant Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 COMT MAOA SLC6A3 SLC6A4
2
Show member pathways
12.39 COMT DRD2 DRD4 MAOA SLC6A3
4 11.92 MAOA SLC6A4 TPH2
5 11.86 SLC6A2 SLC6A3 SLC6A4
6
Show member pathways
11.72 DRD2 MAOA SLC6A3
7 11.69 MAOA SLC6A4 TPH2
8
Show member pathways
11.51 COMT SLC6A2 SLC6A4
9
Show member pathways
11.46 COMT DBH MAOA
10
Show member pathways
11.17 DBH TPH2
11 10.91 DBH SLC6A2
12 10.88 MAOA SLC6A4 TPH2
13
Show member pathways
10.73 DBH MAOA SLC6A2 SLC6A3 SLC6A4 TPH2
14
Show member pathways
10.69 COMT MAOA
15
Show member pathways
10.67 COMT DBH MAOA
16
Show member pathways
10.67 COMT MAOA SLC6A3 SLC6A4
17 10.64 COMT MAOA

GO Terms for Oppositional Defiant Disorder

Cellular components related to Oppositional Defiant Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.76 COMT DBH DRD2 DRD4 MAOA SLC6A2
2 integral component of plasma membrane GO:0005887 9.65 DRD2 DRD4 SLC6A2 SLC6A3 SLC6A4
3 axon GO:0030424 9.5 COMT DRD2 SLC6A3
4 membrane raft GO:0045121 9.13 SLC6A2 SLC6A3 SLC6A4
5 neuron projection GO:0043005 8.92 SLC6A2 SLC6A3 SLC6A4 TPH2

Biological processes related to Oppositional Defiant Disorder according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.8 COMT DRD2 SLC6A2 SLC6A3 SLC6A4
2 locomotory behavior GO:0007626 9.7 DBH DRD2 SLC6A3
3 neurotransmitter transport GO:0006836 9.69 SLC6A2 SLC6A3 SLC6A4
4 social behavior GO:0035176 9.66 DRD4 SLC6A4
5 visual learning GO:0008542 9.66 DBH DRD2
6 response to nicotine GO:0035094 9.65 DRD2 SLC6A3
7 response to cocaine GO:0042220 9.65 DRD2 SLC6A3
8 positive regulation of multicellular organism growth GO:0040018 9.65 DRD2 SLC6A3
9 negative regulation of adenylate cyclase activity GO:0007194 9.64 DRD2 DRD4
10 associative learning GO:0008306 9.64 DBH DRD2
11 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD4
12 behavioral response to cocaine GO:0048148 9.63 DRD2 DRD4
13 dopamine receptor signaling pathway GO:0007212 9.62 DRD2 DRD4
14 response to iron ion GO:0010039 9.62 DRD2 SLC6A3
15 negative regulation of protein secretion GO:0050709 9.61 DRD2 DRD4
16 neurotransmitter biosynthetic process GO:0042136 9.61 SLC6A3 SLC6A4
17 response to amphetamine GO:0001975 9.61 DBH DRD2 DRD4
18 negative regulation of voltage-gated calcium channel activity GO:1901386 9.6 DRD2 DRD4
19 ammonium transmembrane transport GO:0072488 9.59 SLC6A3 SLC6A4
20 prepulse inhibition GO:0060134 9.58 DRD2 SLC6A3
21 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.58 DRD2 DRD4
22 neurotransmitter catabolic process GO:0042135 9.57 COMT MAOA
23 catecholamine metabolic process GO:0006584 9.56 COMT MAOA
24 regulation of dopamine metabolic process GO:0042053 9.55 DRD4 SLC6A3
25 adenohypophysis development GO:0021984 9.54 DRD2 SLC6A3
26 response to pain GO:0048265 9.54 COMT DBH SLC6A2
27 behavioral response to ethanol GO:0048149 9.5 DBH DRD2 DRD4
28 fear response GO:0042596 9.49 DBH DRD4
29 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.48 DRD2 DRD4
30 response to histamine GO:0034776 9.46 DRD2 DRD4
31 dopamine metabolic process GO:0042417 9.43 COMT DRD2 DRD4
32 monoamine transport GO:0015844 9.33 SLC6A2 SLC6A3 SLC6A4
33 dopamine uptake involved in synaptic transmission GO:0051583 9.13 SLC6A2 SLC6A3 SLC6A4
34 dopamine catabolic process GO:0042420 8.92 COMT DBH MAOA SLC6A3

Molecular functions related to Oppositional Defiant Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 symporter activity GO:0015293 9.58 SLC6A2 SLC6A3 SLC6A4
2 drug binding GO:0008144 9.5 DRD2 DRD4 SLC6A3
3 neurotransmitter:sodium symporter activity GO:0005328 9.43 SLC6A3 SLC6A4
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.37 DRD2 DRD4
5 dopamine binding GO:0035240 9.33 DRD2 DRD4 SLC6A3
6 dopamine neurotransmitter receptor activity GO:0004952 9.26 DRD2 DRD4
7 monoamine transmembrane transporter activity GO:0008504 9.13 SLC6A2 SLC6A3 SLC6A4
8 dopamine:sodium symporter activity GO:0005330 8.8 SLC6A2 SLC6A3 SLC6A4

Sources for Oppositional Defiant Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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