MCID: OPT007
MIFTS: 37

Optic Nerve Glioma malady

Eye diseases, Neuronal diseases categories

Summaries for Optic Nerve Glioma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of... more...

MalaCards: Optic Nerve Glioma, also known as optic glioma, is related to neurofibromatosis and malignant glioma. An important gene associated with Optic Nerve Glioma is FABP7 (fatty acid binding protein 7, brain). The compounds ganglioside and kainate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and colon, and related mouse phenotypes are hearing/vestibular/ear and behavior/neurological.

Aliases & Classifications for Optic Nerve Glioma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Neuronal diseases


Aliases & Descriptions:

optic nerve glioma 8 10 60
optic glioma 8 44
glioma of the optic nerve 8


External Ids:

Disease Ontology8 DOID:4992
NCIt39 C4537
MeSH34 D020339

Related Diseases for Optic Nerve Glioma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Optic Nerve Glioma:



Diseases related to optic nerve glioma

Clinical Features for Optic Nerve Glioma

About this section

Drugs & Therapeutics for Optic Nerve Glioma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Optic Nerve Glioma

Drug clinical trials:

Search ClinicalTrials for Optic Nerve Glioma

Search NIH Clinical Center for Optic Nerve Glioma

Search CenterWatch for Optic Nerve Glioma

Genetic Tests for Optic Nerve Glioma

About this section

Anatomical Context for Optic Nerve Glioma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Optic Nerve Glioma:

32
Eye, Brain, Colon

Animal Models for Optic Nerve Glioma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Optic Nerve Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.2NF1, TNFRSF11B, MBP
2MP:00053868.2NF1, NES, FABP7, MBP

Publications for Optic Nerve Glioma

About this section
Sources:
50PubMed
See all sources

Articles related to Optic Nerve Glioma:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery. (23715516)
2013
2
Optic nerve glioma treatment with fractionated stereotactic radiotherapy. (23495806)
2013
3
Concomitant Meningioma and Glioma Within the Same Optic Nerve in Neurofibromatosis Type 1. (23420652)
2013
4
Fractionated stereotactic radiotherapy using Novalis for confined intra-orbital optic nerve glioma in pediatric patient. (23338672)
2013
5
Surgical management of an optic nerve glioma with perineural arachnoidal gliomatosis growth pattern. (23149617)
2013
6
BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. (22892521)
2012
7
Bilateral optic nerve drusen and gliomas in Klippel-Trenaunay syndrome. (21315629)
2011
8
Diagnostic pitfall: optic neuritis mimicking optic nerve glioma. (18721230)
2009
9
Multiple wedge-shaped retinal nerve fiber layer defects in a patient with optic nerve glioma in the contralateral eye: case report. (19820802)
2009
10
Electrophysiological monitoring in a patient with an optic nerve glioma. (18301934)
2008
11
Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm. (19033845)
2008
12
Assessment of chemotherapeutic response in children with proptosis due to optic nerve glioma. (18157537)
2008
13
Retrobulbar cysticercosis masquerading as optic nerve glioma. (17510876)
2007
14
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
15
Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report. (16575300)
2006
16
Optic pathway glioma associated with orbital rhabdomyosarcoma and bilateral optic nerve sheath dural ectasia in a child with neurofibromatosis-1. (16941184)
2006
17
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. (15622533)
2005
18
Optic nerve glioma and optic neuritis mimicking one another: case report. (15987555)
2005
19
Unilateral adult malignant optic nerve glioma. (15085353)
2004
20
Optic nerve glioma in a patient with von Hippel-Lindau syndrome. (12580276)
2003
21
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. (14695164)
2003
22
Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma. (14635617)
2003
23
Malignant optic nerve glioma: metastases to the spinal neuraxis. Case illustration. (12546402)
2003
24
Optic nerve glioma. (11374634)
2001
25
Choroidal neovascular membrane as a feature of optic nerve glioma. (9279953)
1997
26
Large optic nerve glioma. (9715321)
1996
27
Optic nerve glioma mimicking an optic nerve meningioma. (8884101)
1996
28
Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. (8607065)
1996
29
Optic nerve glioma in Japanese patients with neurofibromatosis 1. Case reports and literature review. (1464971)
1992
30
Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin. (1714430)
1991
31
Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis. (2117971)
1990
32
Delayed diagnosis of optic nerve glioma: a preventable cause of visual loss. (2803378)
1989
33
Pulsating orbital plexiform neurofibroma and optic nerve glioma. (2791937)
1989
34
Optic-nerve glioma and pregnancy. (2716632)
1989
35
Hematoma of optic nerve glioma--a cause for sudden proptosis. Magnetic resonance imaging findings. (2522939)
1989
36
Occlusion therapy for optic nerve glioma. (3985819)
1985
37
Atypical visual prognosis with an optic nerve glioma. (2947922)
1985
38
Chiasmatic and hypothalamic extension of optic nerve glioma. (6615308)
1983
39
Optic nerve glioma and neovascular glaucoma: report of a case. (6174146)
1982
40
Long-term survival with optic nerve glioma. (7444747)
1980
41
Arachnoid hyperplasia in optic nerve glioma. (7426583)
1980
42
Large optic nerve glioma with normal vision. (1180757)
1975
43
Optic nerve glioma and cerebellar astrocytoma in a patient with von Recklinghausen's neurofibromatosis. (804254)
1975
44
Malignant optic nerve glioma. Report of a case with electron microscope study. (4707622)
1973
45
The diencephalic syndrome in infants. A review in relation to optic nerve glioma. (4659145)
1972
46
Optic nerve glioma. (6054905)
1967
47
Hemorrhagic glaucoma with optic nerve glioma. (5936809)
1966
48
An electron microscopic study of normal optic nerve and of an optic-nerve glioma. (13764421)
1961
49
Bilateral optic nerve glioma with misleading encephalogram. (13494593)
1957
50
Bilateral Primary Optic Atrophy from Glioma of the Nerves. (19991121)
1937

Genetic Variations for Optic Nerve Glioma

About this section

Expression for genes affiliated with Optic Nerve Glioma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Optic Nerve Glioma

Search GEO for disease gene expression data for Optic Nerve Glioma.

Pathways for genes affiliated with Optic Nerve Glioma

About this section

Compounds for genes affiliated with Optic Nerve Glioma

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Optic Nerve Glioma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1ganglioside449.5NES, MBP
2kainate44 2810.4NES, MBP
3choline44 11 2411.4NES, MBP
4oleic acid44 28 11 2412.3FABP7, NF1
5gaba449.2MBP, FABP7, NES
6prednisolone44 28 1111.2TNFRSF11B, MBP
7paraffin448.8MBP, NES, NF1
8arachidonic acid44 28 11 2411.8TNFRSF11B, FABP7, NF1
9forskolin44 49 1110.7NF1, TNFRSF11B, MBP
10glutamate448.7MBP, FABP7, NES
11progesterone44 59 28 11 2412.7TNFRSF11B, NES, NF1
12estrogen448.2NF1, NES, TNFRSF11B, MBP
13tyrosine448.2NF1, NES, TNFRSF11B, MBP
14retinoic acid44 248.8NF1, NES, FABP7, TNFRSF11B, MBP
15lipid447.8MBP, TNFRSF11B, FABP7, NES, NF1

GO Terms for genes affiliated with Optic Nerve Glioma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Optic Nerve Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.4NES, MBP

Products for genes affiliated with Optic Nerve Glioma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Optic Nerve Glioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet