MCID: OPT007
MIFTS: 37

Optic Nerve Glioma malady

Eye diseases, Neuronal diseases categories

Summaries for Optic Nerve Glioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of... more...

MalaCards: Optic Nerve Glioma, also known as optic glioma, is related to neurofibromatosis and malignant glioma. An important gene associated with Optic Nerve Glioma is FABP7 (fatty acid binding protein 7, brain). The compounds ganglioside and kainate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and colon, and related mouse phenotypes are hearing/vestibular/ear and behavior/neurological.

Aliases & Classifications for Optic Nerve Glioma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Neuronal diseases


Aliases & Descriptions:

optic nerve glioma 8 10 60
optic glioma 8 44
glioma of the optic nerve 8


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Disease Ontology8 DOID:4992
NCIt39 C4537
MeSH34 D020339

Related Diseases for Optic Nerve Glioma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Optic Nerve Glioma:



Diseases related to optic nerve glioma

Clinical Features for Optic Nerve Glioma

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Drugs & Therapeutics for Optic Nerve Glioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Optic Nerve Glioma

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Anatomical Context for Optic Nerve Glioma

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32MalaCards
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MalaCards organs/tissues related to Optic Nerve Glioma:

32
Brain, Eye, Colon

Animal Models for Optic Nerve Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Optic Nerve Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.2NF1, TNFRSF11B, MBP
2MP:00053868.2NF1, NES, FABP7, MBP

Publications for Optic Nerve Glioma

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50PubMed
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Articles related to Optic Nerve Glioma:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Optic nerve glioma treatment with fractionated stereotactic radiotherapy. (23495806)
2013
2
Concomitant Meningioma and Glioma Within the Same Optic Nerve in Neurofibromatosis Type 1. (23420652)
2013
3
Fractionated stereotactic radiotherapy using Novalis for confined intra-orbital optic nerve glioma in pediatric patient. (23338672)
2013
4
Surgical management of an optic nerve glioma with perineural arachnoidal gliomatosis growth pattern. (23149617)
2013
5
Myopia associated with optic nerve gliomas in neurofibromatosis type 1. (22370674)
2012
6
Morning glory disc anomaly in association with ipsilateral optic nerve glioma. (22893090)
2012
7
From the bench to the bedside: Everolimus for subependymal giant cell astrocytomas in Tuberous sclerosis complex, optic nerve regeneration, targeted cytotoxins for gliomas. (21297924)
2011
8
Diagnosis and management of optic nerve glioma. (22071462)
2011
9
Neovascular glaucoma following stereotactic radiosurgery for an optic nerve glioma: a case report. (20714392)
2010
10
Optic nerve sheath fenestration for an isolated optic nerve glioma. (18930671)
2009
11
Electrophysiological monitoring in a patient with an optic nerve glioma. (18301934)
2008
12
Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm. (19033845)
2008
13
Assessment of chemotherapeutic response in children with proptosis due to optic nerve glioma. (18157537)
2008
14
Optic pathway glioma associated with orbital rhabdomyosarcoma and bilateral optic nerve sheath dural ectasia in a child with neurofibromatosis-1. (16941184)
2006
15
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. (15622533)
2005
16
Optic nerve glioma in neurofibromatosis-I. (15695867)
2005
17
Unilateral adult malignant optic nerve glioma. (15085353)
2004
18
Optic nerve glioma and colonic polyposis: report of a new association. (15384896)
2004
19
Optic nerve glioma. (12956473)
2003
20
Optic nerve glioma manifesting as intratumoral hemorrhage in a pregnant woman--case report. (14705324)
2003
21
Malignant optic nerve glioma: metastases to the spinal neuraxis. Case illustration. (12546402)
2003
22
Recent advances in optic nerve glioma with a focus on the young patient. (14624073)
2003
23
Optic nerve glioma in infancy: a case report of the youngest patient in Thailand. (11529326)
2001
24
Growth hormone hypersecretion in a girl with neurofibromatosis type 1 and an optic nerve glioma: resolution following chemotherapy. (11146372)
2000
25
Bilateral optic nerve glioma. (10708361)
1999
26
Choroidal neovascular membrane as a feature of optic nerve glioma. (9279953)
1997
27
Large optic nerve glioma. (9715321)
1996
28
Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient. (8738366)
1996
29
Optic nerve glioma presenting as a huge intrasellar mass. Case report. (7891196)
1994
30
Long-standing follow-up electroretinographic studies after surgical resection of optic nerve glioma. (8272331)
1993
31
Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis. (2117971)
1990
32
Optic nerve glioma and the management of optic nerve tumours in the young. (2611193)
1989
33
Orbital optic nerve glioma in adult life. (2751454)
1989
34
Acute visual loss due to a calcified optic nerve glioma. (2624916)
1989
35
Optic-nerve glioma and pregnancy. (2716632)
1989
36
Hematoma of optic nerve glioma--a cause for sudden proptosis. Magnetic resonance imaging findings. (2522939)
1989
37
Optic nerve glioma. (3411425)
1988
38
Controversy in the management of optic nerve glioma. (2434201)
1987
39
Papilloedema caused by spinal tumour in a case of optic nerve glioma--a clinical report. (6519733)
1984
40
Optic nerve glioma. (7418349)
1980
41
Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma. (486377)
1979
42
Optic nerve glioma: the role of radiation therapy. (922656)
1977
43
Optic nerve glioma and phaeochromocytoma associated with von Recklinghausen's disease: A case report. (403930)
1977
44
Large optic nerve glioma with normal vision. (1180757)
1975
45
Optic nerve glioma in an 18-month-old child. (1119518)
1975
46
The diencephalic syndrome in infants. A review in relation to optic nerve glioma. (4659145)
1972
47
Optic nerve glioma. (6054905)
1967
48
Hemorrhagic glaucoma with optic nerve glioma. (5936809)
1966
49
COLLATERAL HYPERPLASIA AND CYST FORMATION OF ORBITAL LEPTOMENINX: SECONDARY TO OPTIC-NERVE GLIOMA. (14167207)
1964
50
Bilateral Primary Optic Atrophy from Glioma of the Nerves. (19991121)
1937

Genetic Variations for Optic Nerve Glioma

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Expression for genes affiliated with Optic Nerve Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Optic Nerve Glioma

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Pathways for genes affiliated with Optic Nerve Glioma

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Compounds for genes affiliated with Optic Nerve Glioma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Optic Nerve Glioma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1ganglioside449.5NES, MBP
2kainate44 2810.4NES, MBP
3choline44 11 2411.4NES, MBP
4oleic acid44 28 11 2412.3FABP7, NF1
5gaba449.2MBP, FABP7, NES
6prednisolone44 28 1111.2TNFRSF11B, MBP
7paraffin448.8MBP, NES, NF1
8arachidonic acid44 28 11 2411.8TNFRSF11B, FABP7, NF1
9forskolin44 49 1110.7NF1, TNFRSF11B, MBP
10glutamate448.7MBP, FABP7, NES
11progesterone44 59 28 11 2412.7TNFRSF11B, NES, NF1
12estrogen448.2NF1, NES, TNFRSF11B, MBP
13tyrosine448.2NF1, NES, TNFRSF11B, MBP
14retinoic acid44 248.8NF1, NES, FABP7, TNFRSF11B, MBP
15lipid447.8MBP, TNFRSF11B, FABP7, NES, NF1

GO Terms for genes affiliated with Optic Nerve Glioma

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16Gene Ontology
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Biological processes related to Optic Nerve Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.4NES, MBP

Products for genes affiliated with Optic Nerve Glioma

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Sources for Optic Nerve Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet