MCID: OPT007
MIFTS: 41

Optic Nerve Glioma malady

Neuronal diseases, Eye diseases, Cancer diseases categories

Summaries for Optic Nerve Glioma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of... more...

MalaCards: Optic Nerve Glioma, also known as optic glioma, is related to neurofibroma and astrocytoma. An important gene associated with Optic Nerve Glioma is FABP7 (fatty acid binding protein 7, brain). The compounds ganglioside and kainate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and colon, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Aliases & Classifications for Optic Nerve Glioma

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9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 41NCIt, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Eye diseases


Aliases & Descriptions:

optic nerve glioma 9 11 63
optic glioma 9 46
glioma of the optic nerve 9


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Disease Ontology9 DOID:4992
NCIt41 C4537
MeSH36 D020339

Related Diseases for Optic Nerve Glioma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Optic Nerve Glioma:



Diseases related to optic nerve glioma

Symptoms for Optic Nerve Glioma

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Drugs & Therapeutics for Optic Nerve Glioma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Optic Nerve Glioma

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Anatomical Context for Optic Nerve Glioma

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34MalaCards
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MalaCards organs/tissues related to Optic Nerve Glioma:

34
Eye, Brain, Colon

Animal Models for Optic Nerve Glioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Optic Nerve Glioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.5MBP, NF1, TNFRSF11B
2MP:00036318.2MBP, NF1, FABP7, NES
3MP:00053868.1MBP, NF1, FABP7, NES
4MP:00053847.7TNFRSF11B, NES, NF1, MBP

Publications for Optic Nerve Glioma

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53PubMed
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Articles related to Optic Nerve Glioma:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery. (23715516)
2013
2
Optic nerve glioma treatment with fractionated stereotactic radiotherapy. (23495806)
2013
3
Fractionated stereotactic radiotherapy using Novalis for confined intra-orbital optic nerve glioma in pediatric patient. (23338672)
2013
4
Neovascular glaucoma following stereotactic radiosurgery for an optic nerve glioma: a case report. (20714392)
2010
5
Diagnostic pitfall: optic neuritis mimicking optic nerve glioma. (18721230)
2009
6
Multiple wedge-shaped retinal nerve fiber layer defects in a patient with optic nerve glioma in the contralateral eye: case report. (19820802)
2009
7
Optic nerve sheath fenestration for an isolated optic nerve glioma. (18930671)
2009
8
Electrophysiological monitoring in a patient with an optic nerve glioma. (18301934)
2008
9
Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm. (19033845)
2008
10
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
11
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. (15622533)
2005
12
Optic nerve glioma and optic neuritis mimicking one another: case report. (15987555)
2005
13
Unilateral adult malignant optic nerve glioma. (15085353)
2004
14
Optic nerve glioma in a patient with von Hippel-Lindau syndrome. (12580276)
2003
15
Optic nerve glioma. (12956473)
2003
16
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. (14695164)
2003
17
Optic nerve glioma manifesting as intratumoral hemorrhage in a pregnant woman--case report. (14705324)
2003
18
Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma. (14635617)
2003
19
Optic nerve glioma. (11374634)
2001
20
Optic nerve glioma in infancy: a case report of the youngest patient in Thailand. (11529326)
2001
21
Bilateral optic nerve glioma. (10708361)
1999
22
Choroidal neovascular membrane as a feature of optic nerve glioma. (9279953)
1997
23
Large optic nerve glioma. (9715321)
1996
24
Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient. (8738366)
1996
25
Optic nerve glioma mimicking an optic nerve meningioma. (8884101)
1996
26
Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. (8607065)
1996
27
Optic nerve glioma presenting as a huge intrasellar mass. Case report. (7891196)
1994
28
Optic nerve glioma in Japanese patients with neurofibromatosis 1. Case reports and literature review. (1464971)
1992
29
Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin. (1714430)
1991
30
Delayed diagnosis of optic nerve glioma: a preventable cause of visual loss. (2803378)
1989
31
Pulsating orbital plexiform neurofibroma and optic nerve glioma. (2791937)
1989
32
Optic nerve glioma and the management of optic nerve tumours in the young. (2611193)
1989
33
Orbital optic nerve glioma in adult life. (2751454)
1989
34
Acute visual loss due to a calcified optic nerve glioma. (2624916)
1989
35
Optic-nerve glioma and pregnancy. (2716632)
1989
36
Optic nerve glioma. (3411425)
1988
37
Occlusion therapy for optic nerve glioma. (3985819)
1985
38
Papilloedema caused by spinal tumour in a case of optic nerve glioma--a clinical report. (6519733)
1984
39
Chiasmatic and hypothalamic extension of optic nerve glioma. (6615308)
1983
40
Optic nerve glioma and neovascular glaucoma: report of a case. (6174146)
1982
41
Long-term survival with optic nerve glioma. (7444747)
1980
42
Optic nerve glioma. (7418349)
1980
43
Optic nerve glioma: the role of radiation therapy. (922656)
1977
44
Large optic nerve glioma with normal vision. (1180757)
1975
45
Optic nerve glioma in an 18-month-old child. (1119518)
1975
46
The diencephalic syndrome in infants. A review in relation to optic nerve glioma. (4659145)
1972
47
Optic nerve glioma. (6054905)
1967
48
Hemorrhagic glaucoma with optic nerve glioma. (5936809)
1966
49
An electron microscopic study of normal optic nerve and of an optic-nerve glioma. (13764421)
1961
50
Bilateral optic nerve glioma with misleading encephalogram. (13494593)
1957

Variations for Optic Nerve Glioma

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Expression for genes affiliated with Optic Nerve Glioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Optic Nerve Glioma

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Pathways for genes affiliated with Optic Nerve Glioma

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Compounds for genes affiliated with Optic Nerve Glioma

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46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Optic Nerve Glioma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1ganglioside469.6NES, MBP
2kainate46 3010.6MBP, NES
3prednisolone46 30 1211.4MBP, TNFRSF11B
4oleic acid46 30 25 1212.4NF1, FABP7
5choline46 25 1211.3NES, MBP
6indomethacin46 30 62 1212.3MBP, TNFRSF11B
7gaba469.3NES, FABP7, MBP
8glutamate469.1NES, FABP7, MBP
9methotrexate52 46 1211.0MBP, TNFRSF11B
10paraffin468.9MBP, NF1, NES
11arachidonic acid46 30 25 1211.8NF1, FABP7, TNFRSF11B
12forskolin46 52 1210.8TNFRSF11B, NF1, MBP
13progesterone46 30 62 25 1212.7NF1, NES, TNFRSF11B
14cysteine468.5MBP, NF1, TNFRSF11B
15estrogen468.3MBP, NF1, NES, TNFRSF11B
16tyrosine468.2TNFRSF11B, NES, NF1, MBP
17retinoic acid46 258.9MBP, NF1, FABP7, NES, TNFRSF11B
18lipid467.8TNFRSF11B, NES, FABP7, NF1, MBP

GO Terms for genes affiliated with Optic Nerve Glioma

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17Gene Ontology
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Cellular components related to Optic Nerve Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5MBP, FABP7

Biological processes related to Optic Nerve Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1brain developmentGO:0074209.1NF1, NES
2central nervous system developmentGO:0074179.1MBP, NES

Products for genes affiliated with Optic Nerve Glioma

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Sources for Optic Nerve Glioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet