MCID: OPT007
MIFTS: 45

Optic Nerve Glioma

Categories: Neuronal diseases, Eye diseases, Cancer diseases

Aliases & Classifications for Optic Nerve Glioma

MalaCards integrated aliases for Optic Nerve Glioma:

Name: Optic Nerve Glioma 12 41 14 69
Glioma of the Optic Nerve 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4992
MeSH 41 D020339
NCIt 46 C4537
SNOMED-CT 64 254976006 404662003
UMLS 69 C0346326

Summaries for Optic Nerve Glioma

MalaCards based summary : Optic Nerve Glioma, also known as glioma of the optic nerve, is related to neurofibroma and meningioma, familial. An important gene associated with Optic Nerve Glioma is NES (Nestin), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and spinal cord, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of... more...

Related Diseases for Optic Nerve Glioma

Diseases related to Optic Nerve Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 neurofibroma 29.6 MUC1 NF1 S100B SYP
2 meningioma, familial 28.6 GFAP MUC1 NF1 S100B SYP TP53
3 astrocytoma 28.2 GFAP NES NF1 S100B SYP TP53
4 childhood optic nerve glioma 12.3
5 glioma 10.7
6 central nervous system teratoma 10.6 GFAP NES
7 anaplastic ganglioglioma 10.6 GFAP NES
8 pilomatrix carcinoma 10.6 ENO2 MUC1
9 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.6 MBP NES
10 melanotic medulloblastoma 10.6 ENO2 GFAP
11 localized hypertrophic neuropathy 10.6 MUC1 S100B
12 sclerosing perineurioma 10.6 MUC1 S100B
13 finger agnosia 10.6 ENO2 MBP
14 central nervous system germ cell tumor 10.6 GFAP NES
15 cutaneous leiomyosarcoma 10.5 GFAP VIM
16 reticular perineurioma 10.5 MUC1 S100B
17 hydromyelia 10.5 S100B VIM
18 neonatal hypoxic and ischemic brain injury 10.5 ENO2 MBP
19 malignant peritoneal mesothelioma 10.5 MUC1 VIM
20 cerebellar medulloblastoma 10.5 ENO2 GFAP
21 microcystic adenoma 10.5 ENO2 MUC1
22 non-functioning pituitary adenoma 10.5 MUC1 S100B
23 gemistocytic astrocytoma 10.5 GFAP S100B
24 epulis 10.5 ENO2 VIM
25 spindle cell rhabdomyosarcoma 10.5 GFAP MUC1
26 middle cerebral artery infarction 10.5 ENO2 S100B
27 multicentric reticulohistiocytosis 10.5 TNFRSF11B VIM
28 epithelioid leiomyosarcoma 10.5 ENO2 VIM
29 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 GFAP VIM
30 malignant triton tumor 10.5 NF1 S100B
31 duodenal somatostatinoma 10.5 ENO2 NF1
32 biphasic synovial sarcoma 10.5 MUC1 VIM
33 parachordoma 10.4 GFAP MUC1 VIM
34 clear cell meningioma 10.4 GFAP MUC1 VIM
35 malignant mixed mullerian tumor 10.4 MUC1 VIM
36 meningeal melanocytoma 10.4 ENO2 MUC1 S100B
37 bednar tumor 10.4 ENO2 S100B VIM
38 pericardial mesothelioma 10.4 ENO2 MUC1 VIM
39 plexiform schwannoma 10.4 ENO2 GFAP NF1
40 pilomatrixoma 10.4 ENO2 MUC1 S100B
41 myxofibrosarcoma 10.4 MUC1 S100B
42 neuroma 10.4 ENO2 GFAP S100B
43 fibrous meningioma 10.4 MUC1 S100B VIM
44 osteochondroma 10.4 NES S100B VIM
45 nodular hidradenoma 10.4 MUC1 VIM
46 eccrine porocarcinoma 10.4 MUC1 S100B VIM
47 monophasic synovial sarcoma 10.4 MUC1 S100B VIM
48 pleomorphic liposarcoma 10.4 MUC1 S100B VIM
49 spindle cell sarcoma 10.4 MUC1 S100B VIM
50 secondary progressive multiple sclerosis 10.4 ENO2 MBP S100B

Graphical network of the top 20 diseases related to Optic Nerve Glioma:



Diseases related to Optic Nerve Glioma

Symptoms & Phenotypes for Optic Nerve Glioma

MGI Mouse Phenotypes related to Optic Nerve Glioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 VIM ENO2 FABP7 MTO1 GFAP NF1
2 cardiovascular system MP:0005385 9.97 VIM TP53 MIB1 MTO1 GFAP NF1
3 cellular MP:0005384 9.96 VIM TP53 MBP ENO2 MIB1 MTO1
4 homeostasis/metabolism MP:0005376 9.93 VIM TP53 MIB1 FABP7 MTO1 GFAP
5 mortality/aging MP:0010768 9.73 VIM TP53 MIB1 MTO1 GFAP NF1
6 nervous system MP:0003631 9.32 VIM TP53 MBP ENO2 MIB1 FABP7

Drugs & Therapeutics for Optic Nerve Glioma

Drugs for Optic Nerve Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 85622-93-1 5394
3
Carboplatin Approved Phase 3,Phase 1,Phase 2 41575-94-4 10339178 38904 498142
4 Alkylating Agents Phase 3,Phase 1,Phase 2,Early Phase 1
5
Oxaliplatin Approved, Investigational Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
6
Irinotecan Approved, Investigational Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
7
Lenalidomide Approved Phase 2,Phase 1 191732-72-6 216326
8
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
9
Mebendazole Approved, Vet_approved Phase 1, Phase 2 31431-39-7 4030
10
Piperazine Approved, Vet_approved Phase 1, Phase 2 110-85-0 4837
11
Vincristine Approved, Investigational Phase 1, Phase 2 2068-78-2, 57-22-7 5978
12
Peginterferon alfa-2b Approved Phase 2 215647-85-1, 99210-65-8
13
Trioxsalen Approved Phase 2,Phase 1 3902-71-4 5585
14
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
18
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
19
tipifarnib Investigational Phase 2 192185-72-1 159324
20
Camptothecin Experimental Phase 2,Phase 1 7689-03-4
21 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
22 topoisomerase I inhibitors Phase 2,Phase 1
23 Topoisomerase Inhibitors Phase 2,Phase 1
24 Angiogenesis Inhibitors Phase 1, Phase 2
25 Angiogenesis Modulating Agents Phase 1, Phase 2
26 Anti-Infective Agents Phase 1, Phase 2
27 Anti-Bacterial Agents Phase 2,Phase 1
28 Immunosuppressive Agents Phase 2,Phase 1
29 Protein Kinase Inhibitors Phase 2,Phase 1
30 Anthelmintics Phase 1, Phase 2
31 Anticonvulsants Phase 1, Phase 2
32 Antimitotic Agents Phase 1, Phase 2
33 Antiparasitic Agents Phase 1, Phase 2
34 Piperazine citrate Phase 1, Phase 2
35 Antiviral Agents Phase 2
36 Interferon-alpha Phase 2
37 interferons Phase 2
38 Dermatologic Agents Phase 2,Phase 1
39 Dihematoporphyrin Ether Phase 2,Phase 1
40 Ether Phase 2,Phase 1
41 Hematoporphyrin Derivative Phase 2,Phase 1
42 Hematoporphyrins Phase 2,Phase 1
43 Photosensitizing Agents Phase 2,Phase 1
44 Pharmaceutical Solutions Phase 2
45 Micronutrients Phase 2
46 Nicotinic Acids Phase 2
47 Trace Elements Phase 2
48 Vitamin B Complex Phase 2
49 Vitamins Phase 2
50 Citrate Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Phase 3 Study of ANP Therapy vs. TMZ for Optic Pathway Glioma Withdrawn NCT01260103 Phase 3 Temozolomide;ANP Therapy
2 Antineoplaston Therapy in Treating Children With Visual Pathway Glioma Completed NCT00003477 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
3 Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy Completed NCT00679354 Phase 2 cilengitide
4 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
5 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma Completed NCT00070525 Phase 2 tipifarnib
6 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
7 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
8 Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Recruiting NCT02839720 Phase 2 Selumetinib
9 Phase II Pegylated Interferon Recruiting NCT02343224 Phase 2 Pegylated interferon alpha-2b
10 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
11 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
12 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
13 Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours Not yet recruiting NCT03326388 Phase 1, Phase 2 Selumetinib
14 Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas Terminated NCT01338857 Phase 2 Sorafenib (Nexavar)
15 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
16 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
17 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
18 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
19 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
20 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
21 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin
22 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
23 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
24 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia Completed NCT00053963 Phase 1 romidepsin
25 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
26 Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas Completed NCT00012181 Phase 1 alvocidib
27 Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors Recruiting NCT02372409 Phase 1 Doxorubicin;Etoposide
28 Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors Recruiting NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.
29 Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors Recruiting NCT02780804 Phase 1 Entinostat
30 Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Active, not recruiting NCT02415153 Phase 1 Pomalidomide
31 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
32 Ophthalmological Screening and Follow-up of Optic Pathway Gliomas in Children With Neurofibromatosis Type 1. Unknown status NCT02078401
33 Natural History Study of Patients With Neurofibromatosis Type I Recruiting NCT00924196
34 PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1) Active, not recruiting NCT01800032
35 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Active, not recruiting NCT00919750
36 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 busulfan;melphalan;topotecan hydrochloride
37 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
38 Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas Withdrawn NCT02976441 Early Phase 1 Temozolomide
39 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Optic Nerve Glioma

Cochrane evidence based reviews: optic nerve glioma

Genetic Tests for Optic Nerve Glioma

Anatomical Context for Optic Nerve Glioma

MalaCards organs/tissues related to Optic Nerve Glioma:

38
Brain, T Cells, Spinal Cord, Eye, Colon

Publications for Optic Nerve Glioma

Articles related to Optic Nerve Glioma:

(show top 50) (show all 86)
# Title Authors Year
1
Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1. ( 29294511 )
2018
2
Progressive optic nerve glioma: orbital biopsy technique using a surgical navigation system. ( 29426453 )
2018
3
Childhood Optic Nerve Glioma: Vision Loss Due to Biopsy. ( 27046034 )
2016
4
Optic nerve glioma with complete intraocular extension. ( 27830210 )
2016
5
Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome. ( 27230830 )
2016
6
Teaching NeuroImages: Optic nerve glioma with perineural arachnoid gliomatosis in a patient with neurofibromatosis-1. ( 25825471 )
2015
7
Anisometropia in children with neurofibromatosis type 1 and unilateral optic nerve glioma. ( 24924279 )
2014
8
Aggressive Low-Grade Optic Nerve Glioma in Adults. ( 27928317 )
2014
9
Optic nerve glioma: case series with review of clinical, radiologic, molecular, and histopathologic characteristics. ( 24762952 )
2014
10
An 80-year experience with optic nerve glioma cases at the Armed Forces Institute of Pathology: evolution from museum to molecular evaluation suggests possibe interventions in the cellular senescence and microglial pathways (an American Ophthalmological Society thesis). ( 25411512 )
2014
11
Optic nerve glioma: A great mimicker. ( 24575324 )
2014
12
Optic nerve glioma: an update. ( 24736941 )
2014
13
Fractionated stereotactic radiotherapy using Novalis for confined intra-orbital optic nerve glioma in pediatric patient. ( 23338672 )
2013
14
Surgical management of an optic nerve glioma with perineural arachnoidal gliomatosis growth pattern. ( 23149617 )
2013
15
Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery. ( 23715516 )
2013
16
Optic nerve glioma treatment with fractionated stereotactic radiotherapy. ( 23495806 )
2013
17
Myopia associated with optic nerve gliomas in neurofibromatosis type 1. ( 22370674 )
2012
18
Morning glory disc anomaly in association with ipsilateral optic nerve glioma. ( 22893090 )
2012
19
Diagnosis and management of optic nerve glioma. ( 22071462 )
2011
20
Neovascular glaucoma following stereotactic radiosurgery for an optic nerve glioma: a case report. ( 20714392 )
2010
21
Diagnostic pitfall: optic neuritis mimicking optic nerve glioma. ( 18721230 )
2009
22
Optic nerve sheath fenestration for an isolated optic nerve glioma. ( 18930671 )
2009
23
Multiple wedge-shaped retinal nerve fiber layer defects in a patient with optic nerve glioma in the contralateral eye: case report. ( 19820802 )
2009
24
Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm. ( 19033845 )
2008
25
Assessment of chemotherapeutic response in children with proptosis due to optic nerve glioma. ( 18157537 )
2008
26
Electrophysiological monitoring in a patient with an optic nerve glioma. ( 18301934 )
2008
27
Adult optic nerve glioma presenting as central retinal vein occlusion. ( 25390231 )
2007
28
Retrobulbar cysticercosis masquerading as optic nerve glioma. ( 17510876 )
2007
29
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. ( 17111679 )
2006
30
Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report. ( 16575300 )
2006
31
Optic nerve glioma in neurofibromatosis-I. ( 15695867 )
2005
32
Optic nerve glioma and optic neuritis mimicking one another: case report. ( 15987555 )
2005
33
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. ( 15622533 )
2005
34
Optic nerve glioma and colonic polyposis: report of a new association. ( 15384896 )
2004
35
Unilateral adult malignant optic nerve glioma. ( 15085353 )
2004
36
Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma. ( 14635617 )
2003
37
Recent advances in optic nerve glioma with a focus on the young patient. ( 14624073 )
2003
38
Optic nerve glioma in a patient with von Hippel-Lindau syndrome. ( 12580276 )
2003
39
Optic nerve glioma. ( 12956473 )
2003
40
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. ( 14695164 )
2003
41
Malignant optic nerve glioma: metastases to the spinal neuraxis. Case illustration. ( 12546402 )
2003
42
Optic nerve glioma manifesting as intratumoral hemorrhage in a pregnant woman--case report. ( 14705324 )
2003
43
Optic nerve glioma. ( 11374634 )
2001
44
Optic nerve glioma in infancy: a case report of the youngest patient in Thailand. ( 11529326 )
2001
45
Growth hormone hypersecretion in a girl with neurofibromatosis type 1 and an optic nerve glioma: resolution following chemotherapy. ( 11146372 )
2000
46
Bilateral optic nerve glioma. ( 10708361 )
1999
47
Choroidal neovascular membrane as a feature of optic nerve glioma. ( 9279953 )
1997
48
Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. ( 8607065 )
1996
49
Large optic nerve glioma. ( 9715321 )
1996
50
Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient. ( 8738366 )
1996

Variations for Optic Nerve Glioma

Cosmic variations for Optic Nerve Glioma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM476 BRAF central nervous system,optic nerve,glioma,NS c.1799T>A p.V600E 9

Expression for Optic Nerve Glioma

Search GEO for disease gene expression data for Optic Nerve Glioma.

Pathways for Optic Nerve Glioma

Pathways related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.14 ENO2 FABP7 GFAP MAP2 MBP NF1
2 11.54 GFAP MBP TP53 VIM
3
Show member pathways
11.47 GFAP NES VIM
4 11.06 FABP7 GFAP MAP2 NES S100B SYP

GO Terms for Optic Nerve Glioma

Cellular components related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.13 FABP7 GFAP MAP2
2 neuronal cell body GO:0043025 9.02 ENO2 FABP7 MAP2 MBP S100B

Biological processes related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.43 LOX NF1 TP53
2 intermediate filament organization GO:0045109 9.4 GFAP VIM
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 MUC1 TP53
4 response to inorganic substance GO:0010035 9.32 TNFRSF11B TP53
5 extracellular matrix organization GO:0030198 9.26 GFAP LOX NF1 TNFRSF11B
6 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
7 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Optic Nerve Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 GFAP OPTN S100B SYP TP53 VIM
2 structural molecule activity GO:0005198 8.92 GFAP MAP2 NES VIM

Sources for Optic Nerve Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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