MCID: OPT002
MIFTS: 31

Optic Nerve Sheath Meningioma malady

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

Aliases & Descriptions for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 14
Meningioma of Optic Nerve Sheath 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 47 C4538
SNOMED-CT 64 254978007
UMLS 69 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to chondroblastoma and diphtheria, and has symptoms including headache and seizures. An important gene associated with Optic Nerve Sheath Meningioma is MTO1 (Mitochondrial TRNA Translation Optimization 1). The drugs Menthol and Histone Deacetylase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and breast, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 71 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60–70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 chondroblastoma 10.2 KRT5 NF2
2 diphtheria 10.1 NF2 SAMHD1
3 melanotic neurilemmoma 10.1 NF2 SAMHD1
4 epidural abscess 10.1 NF2 SAMHD1
5 neuritis 10.1
6 cervical alveolar soft part sarcoma 10.1 NF2 SCRT1
7 chylocele of tunica vaginalis 10.1 ACE SAMHD1
8 opiate dependence 10.1 ACE SAMHD1
9 immunodeficiency due to a classical component pathway complement deficiency 10.0 CDKN2A NF2
10 monckeberg arteriosclerosis 10.0 CDKN2A NF2
11 suppurative otitis media 10.0 ACE SAMHD1
12 suppurative lymphadenitis 10.0 CDKN2A KRT5
13 tumor of exocrine pancreas 10.0 CDKN2A NF2
14 intermediate malignant teratoma 10.0 CDKN2A KRT5
15 red-green color blindness 10.0 ACE SAMHD1
16 vulvar alveolar soft part sarcoma 10.0 CDKN2A KRT5
17 adenoid squamous cell carcinoma 10.0 CDKN2A KRT5
18 familial lipoprotein lipase deficiency 10.0 CDKN2A KRT5
19 optic neuritis 10.0
20 neuropathy 10.0
21 vascular myelopathy 10.0 CDKN2A NF2
22 spinal cord oligodendroglioma 10.0 CDKN2A KRT5
23 plasmodium ovale malaria 10.0 CDKN2A KRT5
24 estrogen-receptor positive breast cancer 9.9 CDKN2A KRT5
25 pathologic nystagmus 9.9 CDKN2A NF2
26 nodular cutaneous amyloidosis 9.9 CDKN2A KRT5
27 immunodeficiency 37 9.9 CDKN2A NF2
28 vaginal endometrial stromal sarcoma 9.9 CDKN2A KRT5 NF2
29 pyomyositis 9.9 CDKN2A KRT5
30 neurofibromatosis, type 2 9.9
31 choroiditis 9.9
32 melanoma 9.9
33 adenocarcinoma 9.9
34 neurofibromatosis 9.9
35 igg4-related disease 9.9
36 aneurysm 9.9
37 progesterone-receptor positive breast cancer 9.8 CDKN2A KRT5
38 occlusion precerebral artery 9.8 CDKN2A NF2
39 granulomatous myositis 9.3 ACE CDKN2A KRT5 MTO1 NF2 SCRT1
40 diffuse pulmonary fibrosis 8.9 ACE CDKN2A KRT5 MTO1 NF2 PTGDS

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


headache, seizures

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 ACE CDKN2A KRT5 MTO1 NF2 PTGDS
2 mortality/aging MP:0010768 9.5 NF2 PTGDS SAMHD1 ACE CDKN2A KRT5
3 neoplasm MP:0002006 8.92 ACE CDKN2A NF2 PTGDS

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Drugs for Optic Nerve Sheath Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Early Phase 1 2216-51-5 16666
2 Histone Deacetylase Inhibitors Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2
2 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1
3 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
4 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

39
Eye, Lung, Breast, Brain

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 83)
id Title Authors Year
1
Total recovery of optic nerve sheath meningioma. ( 27769976 )
2016
2
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. ( 27103315 )
2016
3
An unusual radiological presentation of optic nerve sheath meningioma. ( 27330394 )
2016
4
Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma. ( 27672598 )
2016
5
Cystic change in primary paediatric optic nerve sheath meningioma. ( 27310300 )
2016
6
Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. ( 26904329 )
2016
7
IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma. ( 26037238 )
2015
8
Pediatric primary optic nerve sheath meningioma. ( 26345328 )
2015
9
Pediatric optic nerve sheath meningioma. ( 24743793 )
2014
10
Primary atypical optic nerve sheath meningioma in a child with restricted diffusion on magnetic resonance imaging. ( 24705258 )
2014
11
Optic nerve sheath meningioma: a case report with 15-year follow-up. ( 23952009 )
2014
12
A rare case of bilateral optic nerve sheath meningioma. ( 25005205 )
2014
13
Unexplained loss of vision in a child: consider bilateral primary optic nerve sheath meningioma. ( 24700154 )
2014
14
Radiation therapy for optic nerve sheath meningioma. ( 24674368 )
2013
15
Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention? ( 23489873 )
2013
16
Radiation optic neuropathy after proton beam therapy for optic nerve sheath meningioma. ( 23429064 )
2013
17
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. ( 24128652 )
2013
18
Optic nerve sheath meningioma in the first decade of life: case report and review of the literature. ( 23071466 )
2012
19
Fusiform appearance of optic nerve sheath meningioma: Correlating clinical and imaging findings. ( 22557880 )
2012
20
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. ( 21640493 )
2012
21
Fractionated stereotactic radiotherapy in patients with optic nerve sheath meningioma. ( 21300458 )
2012
22
Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature. ( 21293073 )
2011
23
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma. ( 19965820 )
2010
24
Long-term results of Gamma Knife surgery for optic nerve sheath meningioma. ( 21121784 )
2010
25
Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. ( 19406585 )
2009
26
Optic nerve sheath meningioma in a patient with choroidal malignant melanoma: a case report of a complex neurocristopathy. ( 19929680 )
2009
27
Optic nerve sheath meningioma with perioptic cyst. ( 19803105 )
2009
28
Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. ( 19324384 )
2009
29
Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis. ( 18347461 )
2008
30
Successful use of mitomycin C to prevent recurrence of the cystic component of an optic nerve sheath meningioma. ( 18520847 )
2008
31
Primary optic nerve sheath meningioma in children. ( 19026318 )
2008
32
Optic nerve sheath meningioma: a case report. ( 19114016 )
2008
33
Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. ( 19085302 )
2008
34
Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. ( 21369471 )
2008
35
Optic nerve sheath meningioma: current diagnosis and treatment. ( 18004966 )
2007
36
Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. ( 17582618 )
2007
37
Radiation retinopathy after fractionated stereotactic conformal radiotherapy for primary intraorbital optic nerve sheath meningioma. ( 17549002 )
2007
38
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. ( 17548993 )
2007
39
New concepts in the diagnosis and management of optic nerve sheath meningioma. ( 16966942 )
2006
40
Cystic optic nerve sheath meningioma. ( 16845313 )
2006
41
Role for surgery as adjuvant therapy in optic nerve sheath meningioma. ( 16855500 )
2006
42
Stereotactic radiation therapy for optic nerve sheath meningioma; an experience at Ramathibodi Hospital. ( 17128842 )
2006
43
Optic nerve sheath meningioma: visual improvement during radiation treatment. ( 16876528 )
2006
44
Carcinoma of the breast metastatic to the optic nerve mimicking an optic nerve sheath meningioma: case report and review of the literature. ( 16648891 )
2005
45
3D ultrasound coronal C-scan imaging for optic nerve sheath meningioma. ( 15665365 )
2005
46
Detection and treatment of optic nerve sheath meningioma. ( 16131419 )
2005
47
Management of sight-threatening optic nerve sheath meningioma with fractionated stereotactic radiotherapy. ( 15807820 )
2005
48
Presumed optic nerve sheath meningioma diagnosed after complicated retrobulbar anesthesia. ( 15510723 )
2004
49
Early improvements in vision after fractionated stereotactic radiotherapy for primary optic nerve sheath meningioma. ( 15297135 )
2004
50
Primary radiotherapy for optic nerve sheath meningioma. ( 15590556 )
2004

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 8.96 CDKN2A NF2
2 negative regulation of cell-matrix adhesion GO:0001953 8.62 CDKN2A NF2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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