MCID: OPT002
MIFTS: 29

Optic Nerve Sheath Meningioma

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 14
Meningioma of Optic Nerve Sheath 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 47 C4538
SNOMED-CT 64 254978007
UMLS 69 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to diphtheria and macrocystic neurilemmoma, and has symptoms including headache and seizures. An important gene associated with Optic Nerve Sheath Meningioma is MTO1 (Mitochondrial TRNA Translation Optimization 1). Affiliated tissues include eye, breast and brain, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 72 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60–70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 diphtheria 10.4 NF2 SAMHD1
2 macrocystic neurilemmoma 10.4 NF2 SAMHD1
3 epidural abscess 10.4 NF2 SAMHD1
4 chondroblastoma 10.3 KRT5 NF2
5 seminoma 10.2 NF2 SCRT1
6 voyeurism 10.1 ACE SAMHD1
7 neuritis 10.1
8 suppurative otitis media 10.1 ACE SAMHD1
9 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.0 CDKN2A NF2
10 opiate dependence 10.0 ACE SAMHD1
11 benign pleural mesothelioma 10.0 CDKN2A NF2
12 cervical adenitis 10.0 CDKN2A KRT5
13 optic neuritis 10.0
14 neuropathy 10.0
15 anal squamous cell carcinoma 10.0 CDKN2A KRT5
16 benign dermal neurilemmoma 10.0 CDKN2A KRT5
17 colon squamous cell carcinoma 10.0 CDKN2A KRT5
18 tumor of exocrine pancreas 10.0 CDKN2A NF2
19 plasmodium ovale malaria 10.0 CDKN2A KRT5
20 c-p angle neurinoma 9.9 CDKN2A NF2
21 familial lipoprotein lipase deficiency 9.9 CDKN2A KRT5
22 childhood oligodendroglioma 9.9 CDKN2A KRT5
23 neurofibromatosis, type 2 9.9
24 choroiditis 9.9
25 melanoma 9.9
26 adenocarcinoma 9.9
27 igg4-related disease 9.9
28 aneurysm 9.9
29 ductal carcinoma in situ 9.8 CDKN2A KRT5
30 rare endometriosis 9.8 CDKN2A KRT5
31 anaerobic pneumonia 9.8 CDKN2A KRT5
32 kidney hypertrophy 9.8 CDKN2A NF2
33 estrogen-receptor negative breast cancer 9.7 CDKN2A KRT5
34 mesothelioma, somatic 9.7 CDKN2A NF2
35 bladder urachal squamous cell carcinoma 9.7 CDKN2A NF2
36 arteriolosclerosis 9.6 CDKN2A KRT5 NF2
37 small cell sarcoma 9.6 CDKN2A NF2
38 brown-vialetto-van laere syndrome 9.3 CDKN2A KRT5
39 vestibular disease 8.1 ACE CDKN2A KRT5 MTO1 NF2 SCRT1
40 cervical adenosquamous carcinoma 7.1 ACE CDKN2A KRT5 MTO1 NF2 PTGDS

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


headache, seizures

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 ACE CDKN2A KRT5 MTO1 NF2 PTGDS
2 mortality/aging MP:0010768 9.5 ACE CDKN2A KRT5 MTO1 NF2 PTGDS
3 neoplasm MP:0002006 8.92 ACE CDKN2A NF2 PTGDS

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

39
Eye, Breast, Brain, Lung

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 87)
id Title Authors Year
1
Diagnosis of optic nerve sheath meningioma during optic nerve sheath decompression. ( 28156180 )
2017
2
Somatostatin Receptor SPECT/CT using (99m)Tc Labeled HYNIC-TOC Aids in Diagnosis of Primary Optic Nerve Sheath Meningioma. ( 28242992 )
2017
3
Visual Outcomes and Local Control After Fractionated Stereotactic Radiotherapy for Optic Nerve Sheath Meningioma. ( 28422769 )
2017
4
Surgical Resection of an Optic Nerve Sheath Meningioma: Relevance of Endoscopic Endonasal Approaches to the Optic Canal. ( 28413768 )
2017
5
An unusual radiological presentation of optic nerve sheath meningioma. ( 27330394 )
2016
6
Cystic change in primary paediatric optic nerve sheath meningioma. ( 27310300 )
2016
7
Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. ( 26904329 )
2016
8
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. ( 27103315 )
2016
9
Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma. ( 27672598 )
2016
10
Total recovery of optic nerve sheath meningioma. ( 27769976 )
2016
11
Pediatric primary optic nerve sheath meningioma. ( 26345328 )
2015
12
IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma. ( 26037238 )
2015
13
Pediatric optic nerve sheath meningioma. ( 24743793 )
2014
14
Optic nerve sheath meningioma: a case report with 15-year follow-up. ( 23952009 )
2014
15
Primary atypical optic nerve sheath meningioma in a child with restricted diffusion on magnetic resonance imaging. ( 24705258 )
2014
16
A rare case of bilateral optic nerve sheath meningioma. ( 25005205 )
2014
17
Unexplained loss of vision in a child: consider bilateral primary optic nerve sheath meningioma. ( 24700154 )
2014
18
Radiation therapy for optic nerve sheath meningioma. ( 24674368 )
2013
19
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. ( 24128652 )
2013
20
Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention? ( 23489873 )
2013
21
Radiation optic neuropathy after proton beam therapy for optic nerve sheath meningioma. ( 23429064 )
2013
22
Fractionated stereotactic radiotherapy in patients with optic nerve sheath meningioma. ( 21300458 )
2012
23
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. ( 21640493 )
2012
24
Optic nerve sheath meningioma in the first decade of life: case report and review of the literature. ( 23071466 )
2012
25
Fusiform appearance of optic nerve sheath meningioma: Correlating clinical and imaging findings. ( 22557880 )
2012
26
Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature. ( 21293073 )
2011
27
Long-term results of Gamma Knife surgery for optic nerve sheath meningioma. ( 21121784 )
2010
28
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma. ( 19965820 )
2010
29
Optic nerve sheath meningioma with perioptic cyst. ( 19803105 )
2009
30
Optic nerve sheath meningioma in a patient with choroidal malignant melanoma: a case report of a complex neurocristopathy. ( 19929680 )
2009
31
Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. ( 19406585 )
2009
32
Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. ( 19324384 )
2009
33
Successful use of mitomycin C to prevent recurrence of the cystic component of an optic nerve sheath meningioma. ( 18520847 )
2008
34
Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. ( 21369471 )
2008
35
Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis. ( 18347461 )
2008
36
Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. ( 19085302 )
2008
37
Primary optic nerve sheath meningioma in children. ( 19026318 )
2008
38
Optic nerve sheath meningioma: a case report. ( 19114016 )
2008
39
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. ( 17548993 )
2007
40
Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. ( 17582618 )
2007
41
Optic nerve sheath meningioma: current diagnosis and treatment. ( 18004966 )
2007
42
Radiation retinopathy after fractionated stereotactic conformal radiotherapy for primary intraorbital optic nerve sheath meningioma. ( 17549002 )
2007
43
Stereotactic radiation therapy for optic nerve sheath meningioma; an experience at Ramathibodi Hospital. ( 17128842 )
2006
44
New concepts in the diagnosis and management of optic nerve sheath meningioma. ( 16966942 )
2006
45
Cystic optic nerve sheath meningioma. ( 16845313 )
2006
46
Optic nerve sheath meningioma: visual improvement during radiation treatment. ( 16876528 )
2006
47
Role for surgery as adjuvant therapy in optic nerve sheath meningioma. ( 16855500 )
2006
48
Management of sight-threatening optic nerve sheath meningioma with fractionated stereotactic radiotherapy. ( 15807820 )
2005
49
Carcinoma of the breast metastatic to the optic nerve mimicking an optic nerve sheath meningioma: case report and review of the literature. ( 16648891 )
2005
50
3D ultrasound coronal C-scan imaging for optic nerve sheath meningioma. ( 15665365 )
2005

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 8.96 CDKN2A NF2
2 negative regulation of cell-matrix adhesion GO:0001953 8.62 CDKN2A NF2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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