MCID: OPT002
MIFTS: 31

Optic Nerve Sheath Meningioma

Categories: Neuronal diseases, Eye diseases, Cancer diseases

Aliases & Classifications for Optic Nerve Sheath Meningioma

MalaCards integrated aliases for Optic Nerve Sheath Meningioma:

Name: Optic Nerve Sheath Meningioma 12 14
Meningioma of Optic Nerve Sheath 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5632
NCIt 46 C4538
SNOMED-CT 64 254978007
UMLS 69 C0346328

Summaries for Optic Nerve Sheath Meningioma

MalaCards based summary : Optic Nerve Sheath Meningioma, also known as meningioma of optic nerve sheath, is related to meningioma, familial and spinal canal and spinal cord meningioma, and has symptoms including seizures and headache. An important gene associated with Optic Nerve Sheath Meningioma is MTO1 (Mitochondrial TRNA Translation Optimization 1). Affiliated tissues include eye, breast and brain, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 72 Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60–70% of cases occur... more...

Related Diseases for Optic Nerve Sheath Meningioma

Diseases related to Optic Nerve Sheath Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 10.9
2 spinal canal and spinal cord meningioma 10.2 NF2 SAMHD1
3 spinal meningioma 10.2 NF2 SAMHD1
4 neuritis 10.2
5 cerebellopontine angle tumor 10.2 NF2 SAMHD1
6 benign mesothelioma 10.2 KRT5 NF2
7 malignant essential hypertension 10.1 ACE SAMHD1
8 optic neuritis 10.1
9 neuropathy 10.1
10 mitral valve insufficiency 10.0 ACE SAMHD1
11 malignant peritoneal mesothelioma 10.0 CDKN2A NF2
12 atypical neurofibroma 10.0 CDKN2A NF2
13 inverted transitional papilloma 10.0 CDKN2A KRT5
14 keratinizing squamous cell carcinoma 9.9 CDKN2A KRT5
15 neurofibromatosis, type iv, of riccardi 9.9
16 choroiditis 9.9
17 melanoma 9.9
18 adenocarcinoma 9.9
19 igg4-related disease 9.9
20 aneurysm 9.9
21 small cell sarcoma 9.9 CDKN2A NF2
22 anal canal squamous cell carcinoma 9.9 CDKN2A KRT5
23 cervical clear cell adenocarcinoma 9.9 CDKN2A KRT5
24 nasal cavity squamous cell carcinoma 9.9 CDKN2A KRT5
25 peritoneal mesothelioma 9.9 CDKN2A NF2
26 necrotizing sialometaplasia 9.9 CDKN2A KRT5
27 anus cancer 9.9 CDKN2A KRT5
28 cellular schwannoma 9.9 CDKN2A NF2
29 pre-malignant neoplasm 9.8 CDKN2A KRT5
30 neurofibroma 9.8 CDKN2A NF2
31 in situ carcinoma 9.8 CDKN2A KRT5
32 nervous system cancer 9.8 CDKN2A NF2
33 malignant pleural mesothelioma 9.7 CDKN2A NF2
34 mesothelioma, malignant 9.7 CDKN2A NF2
35 pleural cancer 9.7 CDKN2A KRT5 NF2
36 cell type cancer 9.6 CDKN2A KRT5
37 malignant peripheral nerve sheath tumor 9.5 CDKN2A NF2
38 optic nerve neoplasm 8.6 ACE CDKN2A KRT5 MTO1 NF2 SCRT1

Graphical network of the top 20 diseases related to Optic Nerve Sheath Meningioma:



Diseases related to Optic Nerve Sheath Meningioma

Symptoms & Phenotypes for Optic Nerve Sheath Meningioma

UMLS symptoms related to Optic Nerve Sheath Meningioma:


seizures, headache

MGI Mouse Phenotypes related to Optic Nerve Sheath Meningioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 PTGDS ACE CDKN2A KRT5 MTO1 NF2
2 mortality/aging MP:0010768 9.5 PTGDS SAMHD1 ACE CDKN2A KRT5 MTO1
3 neoplasm MP:0002006 8.92 PTGDS ACE CDKN2A NF2

Drugs & Therapeutics for Optic Nerve Sheath Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2

Search NIH Clinical Center for Optic Nerve Sheath Meningioma

Genetic Tests for Optic Nerve Sheath Meningioma

Anatomical Context for Optic Nerve Sheath Meningioma

MalaCards organs/tissues related to Optic Nerve Sheath Meningioma:

38
Eye, Breast, Brain, Lung

Publications for Optic Nerve Sheath Meningioma

Articles related to Optic Nerve Sheath Meningioma:

(show top 50) (show all 89)
# Title Authors Year
1
Rapid recovery of vision following early intervention with fractionated stereotactic radiotherapy for optic nerve sheath meningioma. ( 29430199 )
2018
2
Somatostatin Receptor SPECT/CT using (99m)Tc Labeled HYNIC-TOC Aids in Diagnosis of Primary Optic Nerve Sheath Meningioma. ( 28242992 )
2017
3
Diagnosis of optic nerve sheath meningioma during optic nerve sheath decompression. ( 28156180 )
2017
4
Visual Outcomes and Local Control After Fractionated Stereotactic Radiotherapy for Optic Nerve Sheath Meningioma. ( 28422769 )
2017
5
Natural history of primary paediatric optic nerve sheath meningioma: case series and review. ( 29146762 )
2017
6
Surgical Resection of an Optic Nerve Sheath Meningioma: Relevance of Endoscopic Endonasal Approaches to the Optic Canal. ( 28413768 )
2017
7
An unusual radiological presentation of optic nerve sheath meningioma. ( 27330394 )
2016
8
Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report. ( 27103315 )
2016
9
Cystic change in primary paediatric optic nerve sheath meningioma. ( 27310300 )
2016
10
Total recovery of optic nerve sheath meningioma. ( 27769976 )
2016
11
Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma. ( 27672598 )
2016
12
Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. ( 26904329 )
2016
13
Pediatric primary optic nerve sheath meningioma. ( 26345328 )
2015
14
IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma. ( 26037238 )
2015
15
Pediatric optic nerve sheath meningioma. ( 24743793 )
2014
16
Primary atypical optic nerve sheath meningioma in a child with restricted diffusion on magnetic resonance imaging. ( 24705258 )
2014
17
A rare case of bilateral optic nerve sheath meningioma. ( 25005205 )
2014
18
Unexplained loss of vision in a child: consider bilateral primary optic nerve sheath meningioma. ( 24700154 )
2014
19
Optic nerve sheath meningioma: a case report with 15-year follow-up. ( 23952009 )
2014
20
Radiation therapy for optic nerve sheath meningioma. ( 24674368 )
2013
21
Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention? ( 23489873 )
2013
22
Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. ( 24128652 )
2013
23
Radiation optic neuropathy after proton beam therapy for optic nerve sheath meningioma. ( 23429064 )
2013
24
Fusiform appearance of optic nerve sheath meningioma: Correlating clinical and imaging findings. ( 22557880 )
2012
25
Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. ( 21640493 )
2012
26
Optic nerve sheath meningioma in the first decade of life: case report and review of the literature. ( 23071466 )
2012
27
Fractionated stereotactic radiotherapy in patients with optic nerve sheath meningioma. ( 21300458 )
2012
28
Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature. ( 21293073 )
2011
29
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma. ( 19965820 )
2010
30
Long-term results of Gamma Knife surgery for optic nerve sheath meningioma. ( 21121784 )
2010
31
Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. ( 19406585 )
2009
32
Optic nerve sheath meningioma with perioptic cyst. ( 19803105 )
2009
33
Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. ( 19324384 )
2009
34
Optic nerve sheath meningioma in a patient with choroidal malignant melanoma: a case report of a complex neurocristopathy. ( 19929680 )
2009
35
Successful use of mitomycin C to prevent recurrence of the cystic component of an optic nerve sheath meningioma. ( 18520847 )
2008
36
Optic nerve sheath meningioma: a case report. ( 19114016 )
2008
37
Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. ( 21369471 )
2008
38
Primary optic nerve sheath meningioma in children. ( 19026318 )
2008
39
Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis. ( 18347461 )
2008
40
Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. ( 19085302 )
2008
41
Optic nerve sheath meningioma: current diagnosis and treatment. ( 18004966 )
2007
42
Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. ( 17582618 )
2007
43
Radiation retinopathy after fractionated stereotactic conformal radiotherapy for primary intraorbital optic nerve sheath meningioma. ( 17549002 )
2007
44
Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. ( 17548993 )
2007
45
Stereotactic radiation therapy for optic nerve sheath meningioma; an experience at Ramathibodi Hospital. ( 17128842 )
2006
46
Cystic optic nerve sheath meningioma. ( 16845313 )
2006
47
Role for surgery as adjuvant therapy in optic nerve sheath meningioma. ( 16855500 )
2006
48
Optic nerve sheath meningioma: visual improvement during radiation treatment. ( 16876528 )
2006
49
New concepts in the diagnosis and management of optic nerve sheath meningioma. ( 16966942 )
2006
50
Management of sight-threatening optic nerve sheath meningioma with fractionated stereotactic radiotherapy. ( 15807820 )
2005

Variations for Optic Nerve Sheath Meningioma

Expression for Optic Nerve Sheath Meningioma

Search GEO for disease gene expression data for Optic Nerve Sheath Meningioma.

Pathways for Optic Nerve Sheath Meningioma

GO Terms for Optic Nerve Sheath Meningioma

Biological processes related to Optic Nerve Sheath Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 8.96 CDKN2A NF2
2 negative regulation of cell-matrix adhesion GO:0001953 8.62 CDKN2A NF2

Sources for Optic Nerve Sheath Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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