MCID: OPT009
MIFTS: 46

Optic Neuritis malady

Eye category

Summaries for Optic Neuritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. the condition may cause sudden, reduced vision in the affected eye(s). while the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin b-12. vision often returns to normal within 2-3 weeks without treatment. in some cases, corticosteroids are given to speed recovery. if known, the underlying cause should be treated. last updated: 1/11/2011

MalaCards: Optic Neuritis is related to neuromyelitis optica and myelitis. An important gene associated with Optic Neuritis is AQP4 (aquaporin 4), and among its related pathways are Spinal Cord Injury and Glial Cell Differentiation. The compounds cerebrosides and plp (139-151) have been mentioned in the context of this disorder. Affiliated tissues include optic nerve which may cause a complete or partial loss of vision, and related mouse phenotypes are immune system and vision/eye.

Disease Ontology:8 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia:64 Optic neuritis is a multi-etiological condition consisting in the inflammation of the optic nerve that... more...

Aliases & Classifications for Optic Neuritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

optic neuritis 8 43 10 45 61


External Ids:

Disease Ontology8 DOID:1210
ICD9CM27 377.3, 377.30
MeSH35 D009902
NCIt40 C84950
ICD1025 H46

Related Diseases for Optic Neuritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Optic Neuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1neuromyelitis optica31.2MOG, MBP, AQP4
2myelitis30.9AQP4, MBP
3transverse myelitis30.7MBP, AQP4
4acute disseminated encephalomyelitis30.7MBP, HCRT
5uveitis30.6LTA, RCVRN, CXCL11
6tuberculosis30.4MBP
7relapsing-remitting multiple sclerosis30.4MBP, MOG
8leber hereditary optic neuropathy30.2MT-ND4, MT-ND1, MT-ND5, MT-ND6, MT-CO3, MT-ND2
9n syndrome10.7
10ischemic neuropathy10.6
11ischemic optic neuropathy10.6
12systemic lupus erythematosus10.5
13optic neuropathy, anterior ischemic10.5
14measles10.4
15herpes zoster10.3
16chickenpox10.3
17pediatric multiple sclerosis10.3
18nonarteritic anterior ischemic optic neuropathy10.3
19hepatitis a10.3
20herpes zoster ophthalmicus10.3
21neurosyphilis10.3
22branch retinal artery occlusion10.2
23rubella10.2
24antiphospholipid syndrome10.2
25subacute sclerosing panencephalitis10.2
26hepatitis c10.2
27choroiditis10.2
28angiostrongyliasis10.2
29miller fisher syndrome10.2
30aseptic meningitis10.2
31pituitary apoplexy10.2
32meningoencephalitis10.2
33lyme disease10.2
34hepatitis d10.2
35acute retrobulbar neuritis10.2
36chikungunya10.2
37adenoma10.2
38arthritis10.2
39allergic encephalomyelitis10.2
40cytomegalovirus retinitis10.2
41guillain-barr� syndrome10.2
42pediatric systemic lupus erythematosus10.2
43jaccoud's syndrome10.0
44crohn's disease10.0
45acute sphenoidal sinusitis10.0
46pulmonary tuberculosis10.0
47pseudopapilledema10.0
48facial hemiatrophy10.0
49multidrug-resistant tuberculosis10.0
50ankylosing spondylitis10.0

Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to optic neuritis

Clinical Features for Optic Neuritis

Drugs & Therapeutics for Optic Neuritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Optic Neuritis

Drug clinical trials:

Search ClinicalTrials for Optic Neuritis

Search NIH Clinical Center for Optic Neuritis

Search CenterWatch for Optic Neuritis

Genetic Tests for Optic Neuritis

Anatomical Context for Optic Neuritis

Sources:
14FMA
See all sources

FMA organs/tissues related to Optic Neuritis:

14
Optic nerve which may cause a complete or partial loss of vision

Animal Models for Optic Neuritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Optic Neuritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.6AQP4, CCR3, MOG, SOD3, MBP, MPZ
2MP:00053919.6PLP1, RCVRN, LTA, MT-ND6, MBP, AQP4
3MP:00053769.5MBP, AQP4, PLP1, HCRT, LTA, MT-ND6
4MP:00036319.5MOG, MBP, MPZ, GHRH, MT-ND6, MAG

Publications for Optic Neuritis

Sources:
51PubMed
See all sources

Articles related to Optic Neuritis:

(show top 50)    (show all 606)
idTitleAuthorsYear
1
Differential diagnoses to MS: experiences from an optic neuritis clinic. (24158275)
2014
2
Relapsing optic neuritis: a multicentre study of 62 patients. (24177207)
2013
3
Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process. (24083391)
2013
4
Accuracy of routine fat-suppressed FLAIR and diffusion-weighted images in detecting clinically evident optic neuritis. (23386735)
2013
5
Initiation of anti-TNF therapy and the risk of optic neuritis: from the Safety Assessment of Biologic ThERapy (SABER) Study. (23870360)
2013
6
Relationship between serum bilirubin levels and optic neuritis. (24033954)
2013
7
Optic neuritis: from magnocellular to cognitive residual dysfunction. (23619084)
2013
8
The role of optical coherence tomography (OCT) in optic neuritis (ON). (23837230)
2013
9
Subclinical optic neuritis in neuromyelitis optica. (23535569)
2013
10
Optic neuritis combined with hepatitis B and neurosyphilis. (24034115)
2013
11
Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential. (23269599)
2013
12
Optic neuritis: a blurry issue. (23135019)
2012
13
Sphenoid sinus carcinoma mimicking retrobulbar optic neuritis. (22352827)
2012
14
Clinical profile and aetiology of optic neuritis in Hospital Universiti Sains Malaysia--5 years review. (22822635)
2012
15
Words: Perception, "-Omics" Another Epidemic? Vaccine Optic Neuritis; An Amblyopia Symposium; Strasbismus surgery anesthesia. (22989338)
2012
16
Notes on the use of HBO2 with optic neuritis. (22292262)
2011
17
Herpes zoster optic neuritis. (21626168)
2011
18
Adverse neurologic reactions after both doses of pandemic H1N1 influenza vaccine with optic neuritis and demyelination. (20686434)
2011
19
Independent patterns of damage to retinocortical pathways in multiple sclerosis without a previous episode of optic neuritis. (21451995)
2011
20
The limited demyelinating diseases: the voyage of optic neuritis and transverse myelitis to multiple sclerosis and neuromyelitis. (21375450)
2011
21
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis. (21215462)
2011
22
Bilateral optic neuritis associated with the use of infliximab. (22611506)
2011
23
A case of secondary syphilis presenting as optic neuritis. (20182899)
2010
24
Myeloradiculitis with meningoencephalopathy and optic neuritis in a case of previous Chlamydia psittaci infection. (22802266)
2010
25
Cavernous malformation of the optic nerve mimicking optic neuritis. (20351573)
2010
26
Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis. (19465415)
2009
27
Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis. (19273821)
2009
28
Bilateral retrobulbar optic neuritis, Guillain-BarrAc syndrome and asymptomatic central white matter lesions following adult measles infection. (19252366)
2009
29
Reversible bilateral optic neuritis after Infliximab discontinuation in a patient with Crohn's disease. (21172274)
2009
30
Optic neuritis and the risk of multiple sclerosis--what can we learn from a brain MRI scan? (18779851)
2008
31
Fractal analysis of fluoroangiographic patterns in anterior ischaemic optic neuropathy and optic neuritis: a pilot study. (18700918)
2008
32
Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. (18541792)
2008
33
Cognitive dysfunction 24-31 years after isolated optic neuritis. (18573827)
2008
34
Optic neuritis in dogs and cats. (18299014)
2008
35
Neuromyelitis optica and the Optic Neuritis Treatment Trial. (19001178)
2008
36
Optical coherence tomography in optic neuritis. (17198866)
2007
37
Optic neuritis in evolution. (17719374)
2007
38
Optic neuritis. (17577863)
2007
39
Optic neuritis. (17540123)
2007
40
Infliximab-induced retrobulbar optic neuritis. (17601769)
2007
41
Ophthalmic diagnoses in the ED: optic neuritis. (17870491)
2007
42
Presumed infective meningoencephalitis complicated by bilateral optic neuritis. (17932871)
2007
43
A case of branch retinal artery occlusion associated with presumed optic neuritis. (16897231)
2006
44
Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study. (15613143)
2005
45
Optic nerve head circulation in nonarteritic anterior ischemic optic neuropathy and optic neuritis. (15350320)
2004
46
Increased mRNA expression of IL-10 in mononuclear cells in multiple sclerosis and optic neuritis. (7532318)
1995
47
Bilateral optic neuritis and transverse myelitis associated with anticardiolipin antibodies]. (8183007)
1994
48
Optic neuritis and multiple sclerosis: anti-MBP and anti-MBP peptide antibody-secreting cells are accumulated in CSF. (7513391)
1993
49
Cellular immunoreaction to S-antigen in patients with uveitis and optic neuritis]. (8223035)
1993
50
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. (4369864)
1974

Genetic Variations for Optic Neuritis

Expression for genes affiliated with Optic Neuritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Pathways for genes affiliated with Optic Neuritis

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Optic Neuritis

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Optic Neuritis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cerebrosides4510.6MPZ, MBP
2plp (139-151)6010.6MOG, MBP
3mog (35-55)6010.5MBP, MOG
4glatiramer acetate45 1111.5MBP, MOG, PLP1, MPZ
5nogo-66 (1-40)6010.5MBP, MOG
6c3bot (154-182)6010.5MOG, MBP
7ono 25066010.5MOG, MBP
8sulfatide4510.5MPZ, MBP, PLP1, MAG
9ivig4510.4LTA, MAG, MBP
102,3-cyclic nucleotide4510.4MAG, MBP, MPZ, MOG, PLP1
11valine4510.4MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
12nad29 2411.4MT-ND2, MT-ND5, MT-ND4, MT-ND1, MT-ND6
13opiate4510.4CCR3, GHRH, HCRT
14iron45 2411.4SOD3, MT-ND6, MT-ND1, MT-ND4, MT-ND2
15nadh45 11 2412.3MT-ND6, MT-ND2, MT-CO3, MT-ND5, MT-ND4, MT-ND1
16oligonucleotide4510.3AQP4, PLP1, CXCL11, HCRT, LTA, MT-ND5
17cholesterol45 29 11 2413.3MPZ, GHRH, PLP1, SOD3, HCRT, LTA
18methionine4510.3MT-ND6, MT-ND1, SOD3, PLP1, MT-ND2, MPZ
19ganglioside4510.3MPZ, MBP, MAG
20dexamethasone45 50 29 1113.2AQP4, LTA, GHRH, HCRT, CXCL11, CCR3
21arginine4510.2SOD3, MBP, CXCL11, GHRH, MPZ, PLP1
22glutamate4510.2MPZ, HCRT, PLP1, AQP4, MBP, LTA
23silver4510.2MBP, PLP1, MOG
24acetylcholine45 50 29 11 2414.2SOD3, MBP, MAG, LTA, HCRT, PLP1
25urea45 11 2412.2AQP4, GHRH, SOD3
26glucose4510.2MOG, MT-ND4, GHRH, MT-ND1, HCRT, MT-CO3
27threonine4510.2MAG, MT-ND2, MT-ND5, MT-ND4, MT-ND1, MBP
28cyclic amp45 2411.1MAG, GHRH, HCRT, LTA, PLP1
29adenylate4510.1HCRT, CCR3, SOD3, MBP, GHRH
30cysteine4510.1SOD3, MAG, RCVRN, PLP1, AQP4, MBP
31oxygen45 2411.0SOD3, MOG, MT-ND6, MT-ND2, LTA, CCR3
32alanine4510.0MT-ND6, MT-ND2, MT-ND5, MT-ND1, CCR3, MAG
33tyrosine459.9CCR3, LTA, HCRT, MBP, TPPP3, MT-ND6
34serine459.9MAG, MT-ND5, SOD3, MT-ND1, MT-ND6, GHRH
35calcium45 50 11 2412.9HCRT, CXCL11, MAG, LTA, RCVRN, PLP1
36retinoic acid45 2410.8CCR3, MBP, LTA, RCVRN, PLP1, AQP4
37phospholipid459.8MBP, GHRH, RCVRN, PLP1
38lipid459.7MOG, CCR3, MBP, MPZ, SOD3, RCVRN

GO Terms for genes affiliated with Optic Neuritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.3PLP1, MPZ

Biological processes related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077110.2MAG, MBP
2axon ensheathmentGO:00836610.0PLP1, MBP

Molecular functions related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP

Products for genes affiliated with Optic Neuritis

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  • Proteins
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Sources for Optic Neuritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet