MCID: OPT009
MIFTS: 49

Optic Neuritis malady

Rare diseases, Eye diseases categories

Summaries for Optic Neuritis

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NIH Rare Diseases:43 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. the condition may cause sudden, reduced vision in the affected eye(s). while the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin b-12. vision often returns to normal within 2-3 weeks without treatment. in some cases, corticosteroids are given to speed recovery. if known, the underlying cause should be treated. last updated: 1/11/2011

MalaCards based summary: Optic Neuritis is related to neuritis and neuromyelitis optica. An important gene associated with Optic Neuritis is AQP4 (aquaporin 4), and among its related pathways is Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds sulfatide and silver have been mentioned in the context of this disorder. Affiliated tissues include optic nerve which may cause a complete or partial loss of vision, eye and brain, and related mouse phenotypes are vision/eye and nervous system.

Disease Ontology:10 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia:65 Optic neuritis is inflammation of the optic nerve. It is also called papillitis (when the head of the... more...

Aliases & Classifications for Optic Neuritis

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Optic Neuritis, Aliases & Descriptions:

Name: Optic Neuritis 10 43 12 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology10 DOID:1210
NCIt40 C84950
ICD9CM29 377.3, 377.30
MeSH35 D009902
ICD1027 H46

Related Diseases for Optic Neuritis

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Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to optic neuritis

Symptoms for Optic Neuritis

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Drugs & Therapeutics for Optic Neuritis

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Drug clinical trials:

Search ClinicalTrials for Optic Neuritis

Search NIH Clinical Center for Optic Neuritis

Genetic Tests for Optic Neuritis

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Anatomical Context for Optic Neuritis

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MalaCards organs/tissues related to Optic Neuritis:

33
Eye, Brain, T cells, Testes, Pituitary, Breast, Myeloid, Heart, Liver, Lung, Thyroid, B cells, Endothelial

FMA organs/tissues related to Optic Neuritis:

16
Optic nerve which may cause a complete or partial loss of vision

Animal Models for Optic Neuritis or affiliated genes

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MGI Mouse Phenotypes related to Optic Neuritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5AQP4, MOG, PLP1, LTA
2MP:00036318.4LTA, PLP1, MOG, AQP4, MPZ
3MP:00053868.3MPZ, AQP4, MOG, PLP1, LTA
4MP:00053877.8LTA, PLP1, MT-ND2, MOG, AQP4, MPZ

Publications for Optic Neuritis

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Articles related to Optic Neuritis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis. (25736951)
2015
2
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study. (25749692)
2015
3
Mycobacterium w administration for steroid resistant optic neuritis with long-term follow-up. (25231916)
2014
4
Atypical optic neuritis. (25405666)
2014
5
Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis. (23807832)
2013
6
A case of optic neuritis incidentally detected by somatostatin receptor scintigraphy. (24094374)
2013
7
Clinical features of retinal diseases masquerading as retrobulbar optic neuritis. (24033953)
2013
8
Clinical and pathological features of acute optic neuritis in Chinese patients. (23652052)
2013
9
Initiation of anti-TNF therapy and the risk of optic neuritis: from the safety assessment of biologic ThERapy (SABER) Study. (22967869)
2013
10
Historical Issues of Optic neuritis and Sensory Disorder in Persian Traditional Medicine. (23967435)
2013
11
Clinical profile of Malay children with optic neuritis. (22520350)
2012
12
Optic neuritis: experience from a south Indian demyelinating disease registry. (23135022)
2012
13
Orbital Doppler evaluation of blood flow velocities in optic neuritis. (22511838)
2012
14
Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. (22157536)
2012
15
Erythropoietin for acute multiple sclerosis in patients with optic neuritis as a first demyelination event. (22465890)
2012
16
Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. (23024849)
2012
17
Optic neuritis probably induced by isotretinoin. (22748299)
2012
18
Visual outcome following optic neuritis: a 5-year review. (22960967)
2012
19
Notes on the use of HBO2 with optic neuritis. (22292262)
2011
20
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
21
Assessment of outcome predictors after first attack of optic neuritis. (22030428)
2011
22
Diagnostic validity of optic disc and retinal nerve fiber layer evaluations in detecting structural changes after optic neuritis. (20381872)
2010
23
Retinitis and optic neuritis in a child with chickenpox: case report and review of literature. (20622712)
2010
24
Ethambutol-induced optic neuritis and multiple sclerosis: is there an association? (20843609)
2010
25
A case of secondary syphilis presenting as optic neuritis. (20182899)
2010
26
Early observations on optic neuritis and Uhthoff's sign. (20375511)
2010
27
Myeloradiculitis with meningoencephalopathy and optic neuritis in a case of previous Chlamydia psittaci infection. (22802266)
2010
28
Study on the association between IL-2R and IL-7R gene polymorphism and idiopathic demyelinating optic neuritis]. (21211217)
2010
29
Demyelinating optic neuritis in children. (18936195)
2009
30
The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. (18625952)
2008
31
Clinical course of optic neuritis in patients with relapsing neuromyelitis optica. (18195212)
2008
32
Relapsing inflammatory optic neuritis: is it neuromyelitis optica? (18505981)
2008
33
Optic neuritis and the risk of multiple sclerosis--what can we learn from a brain MRI scan? (18779851)
2008
34
A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis. (18204943)
2008
35
Axonal loss and myelin in early ON loss in postacute optic neuritis. (18825673)
2008
36
Electrophysiological evidence for heterogeneity of lesions in optic neuritis. (17898277)
2007
37
Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. (17719649)
2007
38
Historical perspective and future prospective for retinal nerve fiber loss in optic neuritis and multiple sclerosis. (18049278)
2007
39
Optical coherence tomography in optic neuritis. (17198866)
2007
40
A longitudinal conventional and magnetization transfer magnetic resonance imaging study of optic neuritis. (17439896)
2007
41
Cerebrospinal fluid levels of brain specific proteins in optic neuritis. (15222688)
2004
42
Chronic inflammatory demyelinating polyradiculoneuropathy with histologically proven optic neuritis. (11484826)
2001
43
Comparative studies on pattern VECP between patients with ischemic optic neuropathy and optic neuritis. (10990041)
2000
44
Malignant otitis externa with optic neuritis. (9624378)
1998
45
Peptide specificity of anti-myelin basic protein antibodies in patients with acute optic neuritis and the HLA system. (7516573)
1994
46
Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis. (1969423)
1990
47
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
48
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. (4369864)
1974
49
The elimination of non-surgical lesions in brain tumor suspects; pseudo-tumor cerebri, and papilledema without increased intracranial pressure (optic neuritis). (18903109)
1948
50
The Association of Optic Neuritis, Facial Paralysis, and Facial Hemiatrophy. (16693016)
1934

Variations for Optic Neuritis

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Expression for genes affiliated with Optic Neuritis

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Search GEO for disease gene expression data for Optic Neuritis.

Pathways for genes affiliated with Optic Neuritis

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Compounds for genes affiliated with Optic Neuritis

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Sources:
45Novoseek, 26HMDB, 13DrugBank, 51PharmGKB, 30IUPHAR
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Compounds related to Optic Neuritis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1sulfatide459.9MPZ, PLP1
2silver459.6PLP1, MOG
3Ubiquinol 8269.6MT-ND2, MT-ND4
42,3-cyclic nucleotide459.6PLP1, MOG, MPZ
5glatiramer acetate45 1310.5PLP1, MOG, MPZ
6Sulfide269.5MT-ND4, MT-ND2
7QH2269.5MT-ND2, MT-ND4
8Ubiquinone Q2269.4MT-ND2, MT-ND4
9Ubiquinone Q1269.4MT-ND4, MT-ND2
10methionine459.3MPZ, MT-ND2, PLP1
11acetylcholine45 51 30 26 1313.3LTA, PLP1, MOG
12glutamate459.0LTA, PLP1, AQP4, MPZ
13cholesterol45 30 26 1312.0LTA, PLP1, MPZ
14oligonucleotide458.9AQP4, PLP1, LTA
15threonine458.8LTA, MT-ND2, MT-ND4
16nadh45 26 1310.7MT-ND2, MT-CO3, MT-ND4
17lipid458.5MPZ, MOG, MT-ND2, PLP1, LTA
18glucose458.4MOG, MT-ND4, MT-CO3, LTA

GO Terms for genes affiliated with Optic Neuritis

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Cellular components related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432099.6PLP1, MPZ

Products for genes affiliated with Optic Neuritis

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Sources for Optic Neuritis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet