MCID: OPT009
MIFTS: 53

Optic Neuritis malady

Eye diseases category

Summaries for Optic Neuritis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. the condition may cause sudden, reduced vision in the affected eye(s). while the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin b-12. vision often returns to normal within 2-3 weeks without treatment. in some cases, corticosteroids are given to speed recovery. if known, the underlying cause should be treated. last updated: 1/11/2011

MalaCards: Optic Neuritis is related to neuritis and multiple sclerosis. An important gene associated with Optic Neuritis is AQP4 (aquaporin 4), and among its related pathways are Spinal Cord Injury and Glial Cell Differentiation. The compounds cerebrosides and c3bot (154-182) have been mentioned in the context of this disorder. Affiliated tissues include optic nerve which may cause a complete or partial loss of vision, eye and brain, and related mouse phenotypes are immune system and vision/eye.

Disease Ontology:8 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia:63 Optic neuritis is a multi-etiological condition consisting in the inflammation of the optic nerve that... more...

Aliases & Classifications for Optic Neuritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

optic neuritis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:1210
ICD9CM27 377.3, 377.30
MeSH34 D009902
NCIt39 C84950
ICD1025 H46

Related Diseases for Optic Neuritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Optic Neuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1neuritis32.1MPZ, MBP
2multiple sclerosis31.5MBP, MOG, CCR3, MPZ, MAG, LTA
3neuromyelitis optica31.1MOG, MBP, AQP4
4neuropathy30.9MAG, MPZ, MBP
5myelitis30.8AQP4, MBP
6encephalomyelitis30.8MOG, MBP, MPZ, LTA, PLP1, AQP4
7acute disseminated encephalomyelitis30.6HCRT, MBP
8encephalitis30.6TPPP3, AQP4, MBP, MOG
9uveitis30.6CXCL11, RCVRN, LTA
10tuberculosis30.3MBP
11relapsing-remitting multiple sclerosis30.3MBP, MOG
12glaucoma30.0AQP4, MBP
13diabetes mellitus30.0MT-ND1
14transverse myelitis30.0AQP4, MBP
15polyneuropathy30.0MAG, MPZ, MBP
16charcot-marie-tooth disease30.0PLP1, MAG, MPZ, MBP
17myasthenia gravis30.0MOG, MBP, MAG, LTA, PLP1
18malignant glioma30.0CCR3, MBP, MAG, PLP1, AQP4
19retinitis10.9
20ischemic neuropathy10.6
21ischemic optic neuropathy10.6
22systemic lupus erythematosus10.5
23lupus erythematosus10.5
24hepatitis10.4
25optic atrophy10.4
26measles10.4
27meningitis10.4
28papilledema10.4
29choroiditis10.3
30herpes zoster10.3
31chickenpox10.3
32influenza10.3
33optic papillitis10.3
34crohn's disease10.2
35hepatitis a10.2
36chorioretinitis10.2
37branch retinal artery occlusion10.2
38rubella10.2
39antiphospholipid syndrome10.2
40subacute sclerosing panencephalitis10.2
41hepatitis c10.2
42angiostrongyliasis10.2
43miller fisher syndrome10.2
44cat-scratch disease10.2
45q fever10.2
46cerebritis10.2
47aseptic meningitis10.2
48wegener's granulomatosis10.2
49pituitary apoplexy10.2
50meningoencephalitis10.2

Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to optic neuritis

Clinical Features for Optic Neuritis

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Drugs & Therapeutics for Optic Neuritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Optic Neuritis

Drug clinical trials:

Search ClinicalTrials for Optic Neuritis

Search NIH Clinical Center for Optic Neuritis

Search CenterWatch for Optic Neuritis

Genetic Tests for Optic Neuritis

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Anatomical Context for Optic Neuritis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Optic Neuritis:

32
Eye, Brain, T cells, Testes, Pituitary, Breast, Myeloid, Lung, Heart, Liver

FMA organs/tissues related to Optic Neuritis:

14
Optic nerve which may cause a complete or partial loss of vision

Animal Models for Optic Neuritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Optic Neuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.6AQP4, CCR3, MOG, SOD3, MBP, MPZ
2MP:00053919.6MOG, MBP, MT-ND6, LTA, RCVRN, PLP1
3MP:00053769.5SOD3, MBP, MPZ, GHRH, MT-ND6, LTA
4MP:00036319.5MOG, MBP, MPZ, GHRH, MT-ND6, MAG

Publications for Optic Neuritis

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50PubMed
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Articles related to Optic Neuritis:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Clinical and pathological features of acute optic neuritis in Chinese patients. (23652052)
2013
2
Historical Issues of Optic neuritis and Sensory Disorder in Persian Traditional Medicine. (23967435)
2013
3
Relationship between cerebrospinal fluid biomarkers for inflammation, demyelination and neurodegeneration in acute optic neuritis. (24116216)
2013
4
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. (23609767)
2013
5
Atypical cat scratch disease with vitritis, serous macular detachment, neuroretinitis, and retrobulbar optic neuritis. (22366917)
2013
6
Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients. (23128668)
2013
7
Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis. (23857611)
2013
8
Optic neuritis in neuromyelitis optica. (23545439)
2013
9
Inner nuclear layer thickening is inversley proportional to retinal ganglion cell loss in optic neuritis. (24098599)
2013
10
Three-dimensional geometries representing the retinal nerve fiber layer in multiple sclerosis, optic neuritis, and healthy eyes. (23774269)
2013
11
Clinical profile of Malay children with optic neuritis. (22520350)
2012
12
Orbital Doppler evaluation of blood flow velocities in optic neuritis. (22511838)
2012
13
Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. (23024849)
2012
14
Effector and regulatory T cells in patients with acute optic neuritis. (22248727)
2012
15
Severe optic neuritis in a patient with combined neuromyelitis optica spectrum disease and primary SjAPgren's syndrome: a case report. (23176203)
2012
16
Clinical characteristics of optic neuritis in Taiwanese children. (21852809)
2011
17
Sustained motion perception deficit following optic neuritis: Behavioral and cortical evidence. (21670440)
2011
18
Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis. (21813786)
2011
19
Oligoclonal bands predict multiple sclerosis after optic neuritis: a literature survey. (21159718)
2011
20
Bilateral and recurrent optic neuritis in multiple sclerosis. (20569226)
2011
21
Neuroplasticity predicts outcome of optic neuritis independent of tissue damage. (20186956)
2010
22
Bilateral Choroidal Osteoma Associated with Optic Neuritis in BehAset's Disease. (20337295)
2010
23
Lyme optic neuritis. (20621802)
2010
24
Brain MRI lesions characteristic of neuromyelitis optica and positive anti-aquaporin 4-antibody may predict longitudinal extensive myelitis and optic neuritis in SjAPgren's syndrome. (20558506)
2010
25
Bilateral cytomegalovirus retinitis with unilateral optic neuritis in Good syndrome. (20577863)
2010
26
Optic neuritis associated with Q fever: case report and literature review. (20605503)
2010
27
Encephalitis during interferon beta-1a treatment in a child with optic neuritis. (20124209)
2010
28
Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis. (19296047)
2009
29
Stereoacuity testing discloses abnormalities in multiple sclerosis without optic neuritis. (19726941)
2009
30
Management of optic neuritis and impact of clinical trials: an international survey. (18926549)
2009
31
Bilateral optic neuritis as initial manifestation of neurosyphilis in a HIV-positive patient. (18949905)
2008
32
Visual field defects in acute optic neuritis--distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution. (18239928)
2008
33
Optic neuritis due to solvent abuse. (18392432)
2008
34
Management of optic neuritis in Canada: survey of ophthalmologists and neurologists. (18574931)
2008
35
Unilateral optic neuritis as the presenting symptom of human immunodeficiency virus toxoplasmosis infection. (17986296)
2008
36
MRI of optic neuritis in a rat model. (18394926)
2008
37
Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial. (18625951)
2008
38
Optic neuritis as the first manifestation of rheumatoid arthritis. (18769294)
2008
39
Retrobulbar optic neuritis: a complication of Lyme disease? (18024698)
2007
40
Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. (17852796)
2007
41
Improvement in conduction velocity after optic neuritis measured with the multifocal VEP. (17251467)
2007
42
Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. (17086896)
2006
43
Immunogenetics of optic neuritis in children with multiple sclerosis]. (12506649)
2002
44
Anti-myelin basic protein and anti-proteolipid protein antibody-secreting cells in the cerebrospinal fluid of patients with acute optic neuritis. (7524468)
1994
45
Autoimmune T cell repertoire in optic neuritis and multiple sclerosis: T cells recognising multiple myelin proteins are accumulated in cerebrospinal fluid. (7515411)
1994
46
Optic neuritis and ischemic neuropathy. What we thought we already knew. (1841571)
1991
47
The germline repertoire of T-cell receptor beta chain genes in patients with relapsing/remitting multiple sclerosis or optic neuritis. (2139432)
1990
48
Bilateral chorioretinitis, centripetal optic neuritis, and encephalitis in a llama. (2722665)
1989
49
The elimination of non-surgical lesions in brain tumor suspects; pseudo-tumor cerebri, and papilledema without increased intracranial pressure (optic neuritis). (18903109)
1948
50
THREE CASES OF CHRONIC TUBERCULOUS CHOROIDITIS, WITH A COMMENT ON THE COMPLICATION, OPTIC NEURITIS. (18168366)
1924

Genetic Variations for Optic Neuritis

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Expression for genes affiliated with Optic Neuritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Pathways for genes affiliated with Optic Neuritis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Optic Neuritis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Optic Neuritis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cerebrosides4410.6MPZ, MBP
2c3bot (154-182)5910.6MOG, MBP
3ono 25065910.5MOG, MBP
4glatiramer acetate44 1111.5MOG, MBP, MPZ, PLP1
5nogo-66 (1-40)5910.5MOG, MBP
6mog (35-55)5910.5MOG, MBP
7plp (139-151)5910.5MOG, MBP
8sulfatide4410.5MBP, MPZ, MAG, PLP1
9ivig4410.4MBP, MAG, LTA
102,3-cyclic nucleotide4410.4PLP1, MAG, MPZ, MBP, MOG
11valine4410.4MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
12nad28 2411.4MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
13opiate4410.4CCR3, GHRH, HCRT
14iron44 2411.4SOD3, MT-ND6, MT-ND1, MT-ND4, MT-ND2
15nadh44 11 2412.3MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-CO3, MT-ND2
16oligonucleotide4410.3MT-ND5, LTA, HCRT, CXCL11, PLP1, AQP4
17cholesterol44 28 11 2413.3SOD3, MPZ, GHRH, LTA, HCRT, PLP1
18methionine4410.3SOD3, MPZ, MT-ND6, MT-ND1, MT-ND5, MT-ND2
19ganglioside4410.3MBP, MPZ, MAG
20dexamethasone44 49 28 1113.2CCR3, GHRH, LTA, HCRT, CXCL11, AQP4
21arginine4410.2SOD3, MBP, MPZ, GHRH, CXCL11, PLP1
22glutamate4410.2MBP, MPZ, GHRH, LTA, HCRT, PLP1
23silver4410.2PLP1, MBP, MOG
24acetylcholine44 49 28 11 2414.2MOG, SOD3, MBP, MAG, LTA, HCRT
25urea44 11 2412.2AQP4, GHRH, SOD3
26glucose4410.2MOG, GHRH, MT-ND1, MT-ND4, MT-CO3, LTA
27threonine4410.2MBP, MT-ND1, MT-ND4, MT-ND5, MT-ND2, MAG
28cyclic amp44 2411.1GHRH, MAG, LTA, HCRT, PLP1
29adenylate4410.1HCRT, GHRH, MBP, SOD3, CCR3
30cysteine4410.1CCR3, SOD3, MBP, MPZ, MAG, RCVRN
31oxygen44 2411.0CCR3, MOG, SOD3, MT-ND6, MT-ND2, LTA
32alanine4410.0CCR3, SOD3, MBP, MT-ND6, MT-ND1, MT-ND5
33tyrosine449.9CCR3, MBP, MPZ, MT-ND6, MAG, LTA
34serine449.9MOG, SOD3, MBP, MPZ, GHRH, MT-ND6
35calcium44 49 11 2412.9CCR3, MOG, GHRH, MAG, LTA, HCRT
36retinoic acid44 2410.8CCR3, MBP, LTA, RCVRN, PLP1, AQP4
37phospholipid449.8MBP, GHRH, RCVRN, PLP1
38lipid449.7MPZ, MBP, SOD3, MOG, CCR3, GHRH

GO Terms for genes affiliated with Optic Neuritis

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16Gene Ontology
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Cellular components related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.3PLP1, MPZ

Biological processes related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077110.2MAG, MBP
2axon ensheathmentGO:00836610.0PLP1, MBP

Molecular functions related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP

Products for genes affiliated with Optic Neuritis

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Sources for Optic Neuritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet