MCID: OPT009
MIFTS: 49

Optic Neuritis malady

Rare diseases, Eye diseases, Neuronal diseases categories
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Summaries for Optic Neuritis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. the condition may cause sudden, reduced vision in the affected eye(s). while the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin b-12. vision often returns to normal within 2-3 weeks without treatment. in some cases, corticosteroids are given to speed recovery. if known, the underlying cause should be treated. last updated: 1/11/2011

MalaCards: Optic Neuritis is related to neuritis and multiple sclerosis. An important gene associated with Optic Neuritis is AQP4 (aquaporin 4), and among its related pathways is Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds sulfatide and silver have been mentioned in the context of this disorder. Affiliated tissues include optic nerve which may cause a complete or partial loss of vision, eye and brain, and related mouse phenotypes are vision/eye and nervous system.

Disease Ontology:8 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia:65 Optic neuritis is a multi-etiological condition consisting in the inflammation of the optic nerve that... more...

Aliases & Classifications for Optic Neuritis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Neuronal diseases


Aliases & Descriptions:

optic neuritis 8 43 10 45 62


External Ids:

Disease Ontology8 DOID:1210
NCIt40 C84950
ICD9CM27 377.3, 377.30
MeSH35 D009902
ICD1025 H46

Related Diseases for Optic Neuritis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to optic neuritis

Symptoms for Optic Neuritis

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Drugs & Therapeutics for Optic Neuritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Optic Neuritis

Search NIH Clinical Center for Optic Neuritis

Genetic Tests for Optic Neuritis

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Anatomical Context for Optic Neuritis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Optic Neuritis:

33
Eye, Brain, T cells, Testes, Pituitary, Myeloid, Breast, Lung, Liver, Heart

FMA organs/tissues related to Optic Neuritis:

14
Optic nerve which may cause a complete or partial loss of vision

Animal Models for Optic Neuritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Optic Neuritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5LTA, AQP4, MOG, PLP1
2MP:00036318.4LTA, PLP1, MOG, AQP4, MPZ
3MP:00053868.3LTA, MOG, AQP4, MPZ, PLP1
4MP:00053877.8PLP1, LTA, MT-ND2, MOG, AQP4, MPZ

Publications for Optic Neuritis

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52PubMed
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Articles related to Optic Neuritis:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis. (23807832)
2013
2
A case of optic neuritis incidentally detected by somatostatin receptor scintigraphy. (24094374)
2013
3
Clinical features of retinal diseases masquerading as retrobulbar optic neuritis. (24033953)
2013
4
Clinical and pathological features of acute optic neuritis in Chinese patients. (23652052)
2013
5
Initiation of anti-TNF therapy and the risk of optic neuritis: from the safety assessment of biologic ThERapy (SABER) Study. (22967869)
2013
6
Historical Issues of Optic neuritis and Sensory Disorder in Persian Traditional Medicine. (23967435)
2013
7
Clinical profile of Malay children with optic neuritis. (22520350)
2012
8
Optic neuritis: experience from a south Indian demyelinating disease registry. (23135022)
2012
9
Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. (22157536)
2012
10
Erythropoietin for acute multiple sclerosis in patients with optic neuritis as a first demyelination event. (22465890)
2012
11
Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. (23024849)
2012
12
Optic neuritis probably induced by isotretinoin. (22748299)
2012
13
Visual outcome following optic neuritis: a 5-year review. (22960967)
2012
14
Bilateral atypical optic neuritis associated with tuberculosis in an immunocompromised patient. (23569976)
2012
15
Notes on the use of HBO2 with optic neuritis. (22292262)
2011
16
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
17
Assessment of outcome predictors after first attack of optic neuritis. (22030428)
2011
18
Diagnostic validity of optic disc and retinal nerve fiber layer evaluations in detecting structural changes after optic neuritis. (20381872)
2010
19
Retinitis and optic neuritis in a child with chickenpox: case report and review of literature. (20622712)
2010
20
Ethambutol-induced optic neuritis and multiple sclerosis: is there an association? (20843609)
2010
21
A case of secondary syphilis presenting as optic neuritis. (20182899)
2010
22
Myeloradiculitis with meningoencephalopathy and optic neuritis in a case of previous Chlamydia psittaci infection. (22802266)
2010
23
Study on the association between IL-2R and IL-7R gene polymorphism and idiopathic demyelinating optic neuritis]. (21211217)
2010
24
Demyelinating optic neuritis in children. (18936195)
2009
25
Radiation-induced optic neuritis after pituitary adenoma radiosurgery in a patient with multiple sclerosis: case report. (19099198)
2009
26
The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. (18625952)
2008
27
Clinical course of optic neuritis in patients with relapsing neuromyelitis optica. (18195212)
2008
28
Relapsing inflammatory optic neuritis: is it neuromyelitis optica? (18505981)
2008
29
Optic neuritis and the risk of multiple sclerosis--what can we learn from a brain MRI scan? (18779851)
2008
30
A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis. (18204943)
2008
31
Axonal loss and myelin in early ON loss in postacute optic neuritis. (18825673)
2008
32
Electrophysiological evidence for heterogeneity of lesions in optic neuritis. (17898277)
2007
33
Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. (17719649)
2007
34
Historical perspective and future prospective for retinal nerve fiber loss in optic neuritis and multiple sclerosis. (18049278)
2007
35
Optical coherence tomography in optic neuritis. (17198866)
2007
36
A longitudinal conventional and magnetization transfer magnetic resonance imaging study of optic neuritis. (17439896)
2007
37
Optic neuritis in evolution. (17719374)
2007
38
Cerebrospinal fluid levels of brain specific proteins in optic neuritis. (15222688)
2004
39
Overlap of optic neuritis and anterior ischemic optic neuropathy. (12601716)
2003
40
Chronic inflammatory demyelinating polyradiculoneuropathy with histologically proven optic neuritis. (11484826)
2001
41
Comparative studies on pattern VECP between patients with ischemic optic neuropathy and optic neuritis. (10990041)
2000
42
Malignant otitis externa with optic neuritis. (9624378)
1998
43
Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. (8624683)
1996
44
Increased mRNA expression of IL-10 in mononuclear cells in multiple sclerosis and optic neuritis. (7532318)
1995
45
Peptide specificity of anti-myelin basic protein antibodies in patients with acute optic neuritis and the HLA system. (7516573)
1994
46
Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis. (1969423)
1990
47
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
48
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. (4369864)
1974
49
The elimination of non-surgical lesions in brain tumor suspects; pseudo-tumor cerebri, and papilledema without increased intracranial pressure (optic neuritis). (18903109)
1948
50
The Association of Optic Neuritis, Facial Paralysis, and Facial Hemiatrophy. (16693016)
1934

Variations for Optic Neuritis

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Expression for genes affiliated with Optic Neuritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Pathways for genes affiliated with Optic Neuritis

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database
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Compounds for genes affiliated with Optic Neuritis

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Optic Neuritis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1sulfatide459.9MPZ, PLP1
2silver459.6PLP1, MOG
3Ubiquinol 8249.6MT-ND2, MT-ND4
42,3-cyclic nucleotide459.6PLP1, MOG, MPZ
5glatiramer acetate45 1110.5PLP1, MOG, MPZ
6Sulfide249.5MT-ND4, MT-ND2
7QH2249.5MT-ND2, MT-ND4
8Ubiquinone Q2249.4MT-ND2, MT-ND4
9Ubiquinone Q1249.4MT-ND4, MT-ND2
10methionine459.3MPZ, MT-ND2, PLP1
11acetylcholine45 51 29 24 1113.3LTA, PLP1, MOG
12glutamate459.0LTA, PLP1, AQP4, MPZ
13cholesterol45 29 24 1112.0LTA, PLP1, MPZ
14oligonucleotide458.9AQP4, PLP1, LTA
15threonine458.8LTA, MT-ND2, MT-ND4
16nadh45 24 1110.7MT-ND2, MT-CO3, MT-ND4
17lipid458.5MPZ, MOG, MT-ND2, PLP1, LTA
18glucose458.4MOG, MT-ND4, MT-CO3, LTA

GO Terms for genes affiliated with Optic Neuritis

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16Gene Ontology
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Cellular components related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:0432099.6PLP1, MPZ

Products for genes affiliated with Optic Neuritis

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Sources for Optic Neuritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet