MCID: OPT009
MIFTS: 53

Optic Neuritis malady

Eye diseases category

Summaries for Optic Neuritis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain. the condition may cause sudden, reduced vision in the affected eye(s). while the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin b-12. vision often returns to normal within 2-3 weeks without treatment. in some cases, corticosteroids are given to speed recovery. if known, the underlying cause should be treated. last updated: 1/11/2011

MalaCards: Optic Neuritis is related to neuritis and multiple sclerosis. An important gene associated with Optic Neuritis is AQP4 (aquaporin 4), and among its related pathways are Spinal Cord Injury and Glial Cell Differentiation. The compounds cerebrosides and c3bot (154-182) have been mentioned in the context of this disorder. Affiliated tissues include optic nerve which may cause a complete or partial loss of vision, eye and brain, and related mouse phenotypes are immune system and vision/eye.

Disease Ontology:8 An optic nerve disease that results in inflammation located in optic nerve which may cause a complete or partial loss of vision.

Wikipedia:63 Optic neuritis is a multi-etiological condition consisting in the inflammation of the optic nerve that... more...

Aliases & Classifications for Optic Neuritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

optic neuritis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:1210
ICD9CM27 377.3, 377.30
MeSH34 D009902
NCIt39 C84950
ICD1025 H46

Related Diseases for Optic Neuritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Optic Neuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1neuritis32.1MPZ, MBP
2multiple sclerosis31.5MBP, MOG, CCR3, MPZ, MAG, LTA
3neuromyelitis optica31.1MOG, MBP, AQP4
4neuropathy30.9MAG, MPZ, MBP
5myelitis30.8AQP4, MBP
6encephalomyelitis30.8MOG, MBP, MPZ, LTA, PLP1, AQP4
7acute disseminated encephalomyelitis30.6HCRT, MBP
8encephalitis30.6TPPP3, AQP4, MBP, MOG
9uveitis30.6CXCL11, RCVRN, LTA
10tuberculosis30.3MBP
11relapsing-remitting multiple sclerosis30.3MBP, MOG
12glaucoma30.0AQP4, MBP
13diabetes mellitus30.0MT-ND1
14transverse myelitis30.0AQP4, MBP
15polyneuropathy30.0MAG, MPZ, MBP
16charcot-marie-tooth disease30.0PLP1, MAG, MPZ, MBP
17myasthenia gravis30.0MOG, MBP, MAG, LTA, PLP1
18malignant glioma30.0CCR3, MBP, MAG, PLP1, AQP4
19retinitis10.9
20ischemic neuropathy10.6
21ischemic optic neuropathy10.6
22systemic lupus erythematosus10.5
23lupus erythematosus10.5
24hepatitis10.4
25optic atrophy10.4
26measles10.4
27meningitis10.4
28papilledema10.4
29choroiditis10.3
30herpes zoster10.3
31chickenpox10.3
32influenza10.3
33optic papillitis10.3
34crohn's disease10.2
35hepatitis a10.2
36chorioretinitis10.2
37branch retinal artery occlusion10.2
38rubella10.2
39antiphospholipid syndrome10.2
40subacute sclerosing panencephalitis10.2
41hepatitis c10.2
42angiostrongyliasis10.2
43miller fisher syndrome10.2
44cat-scratch disease10.2
45q fever10.2
46cerebritis10.2
47aseptic meningitis10.2
48wegener's granulomatosis10.2
49pituitary apoplexy10.2
50meningoencephalitis10.2

Graphical network of the top 20 diseases related to Optic Neuritis:



Diseases related to optic neuritis

Clinical Features for Optic Neuritis

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Drugs & Therapeutics for Optic Neuritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Optic Neuritis

Drug clinical trials:

Search ClinicalTrials for Optic Neuritis

Search NIH Clinical Center for Optic Neuritis

Search CenterWatch for Optic Neuritis

Genetic Tests for Optic Neuritis

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Anatomical Context for Optic Neuritis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Optic Neuritis:

32
Eye, Brain, T cells, Testes, Pituitary, Myeloid, Breast, Lung, Liver, Heart

FMA organs/tissues related to Optic Neuritis:

14
Optic nerve which may cause a complete or partial loss of vision

Animal Models for Optic Neuritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Optic Neuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.6AQP4, CCR3, MOG, SOD3, MBP, MPZ
2MP:00053919.6MOG, MBP, MT-ND6, LTA, RCVRN, PLP1
3MP:00053769.5SOD3, MBP, MPZ, GHRH, MT-ND6, LTA
4MP:00036319.5MOG, MBP, MPZ, GHRH, MT-ND6, MAG

Publications for Optic Neuritis

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50PubMed
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Articles related to Optic Neuritis:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Clinical features of retinal diseases masquerading as retrobulbar optic neuritis. (24033953)
2013
2
Do patients with non-arteritic ischemic optic neuritis have increased risk for cardiovascular and cerebrovascular events? (23364133)
2013
3
Plasma exchange is effective in a 13-year-old girl with steroid-resistant bilateral optic neuritis. (23468279)
2013
4
Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system. (23609766)
2013
5
Neuromyelitis optica and aquaporin-4 (AQP4) autoantibodies in consecutive optic neuritis patients in Southern Finland. (23773223)
2013
6
Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy. (24088641)
2013
7
Erythropoietin for acute multiple sclerosis in patients with optic neuritis as a first demyelination event. (22465890)
2012
8
Role of NMO-IgG in distinguishing the type of optic neuritis. (22105332)
2012
9
Disc swelling and mild initial visual acuity loss predict a better short-term visual acuity outcome in bilateral acute optic neuritis. (22819060)
2012
10
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. (22167100)
2012
11
Vaccination-induced bilateral optic neuritis: rare but existing. (23240376)
2012
12
Words: Perception, "-Omics" Another Epidemic? Vaccine Optic Neuritis; An Amblyopia Symposium; Strasbismus surgery anesthesia. (22989338)
2012
13
Clinical approach to optic neuritis: pitfalls, red flags and differential diagnosis. (21694809)
2011
14
Effect of optic neuritis on progressive axonal damage in multiple sclerosis patients. (21300734)
2011
15
Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography. (21917458)
2011
16
Comparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis. (21131852)
2011
17
Relapsing uveitis and optic neuritis due to chronic Q fever. (20733024)
2011
18
Human herpesvirus 6-associated uveitis with optic neuritis diagnosed by multiplex PCR. (21814813)
2011
19
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. (21641403)
2011
20
Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis. (21791585)
2011
21
Bilateral optic neuritis associated with the use of infliximab. (22611506)
2011
22
Concurrent macular oedema and optic neuritis in Crohn's disease with varied response to steroids. (22479295)
2010
23
Juxtapapillary choroidal neovascular membrane following optic neuritis. (19889151)
2010
24
Bilateral optic neuritis in leprosy. (19491968)
2009
25
The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. (18625952)
2008
26
Relapsing inflammatory optic neuritis: is it neuromyelitis optica? (18505981)
2008
27
Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis. (18505777)
2008
28
Effects of high-dose prednisolone on optic nerve head blood flow in patients with acute optic neuritis. (18575879)
2008
29
Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: intravitreal triamcinolone acetonide therapy of four eyes. (17721501)
2008
30
Correlation between full-field and multifocal VEPs in optic neuritis. (17680288)
2008
31
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. (18335521)
2008
32
Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis. (18347461)
2008
33
Predictive role of evoked potential examinations in patients with clinically isolated optic neuritis in light of the revised McDonald criteria. (18208873)
2008
34
Historical perspective and future prospective for retinal nerve fiber loss in optic neuritis and multiple sclerosis. (18049278)
2007
35
A comparative study of visual evoked potentials in optic neuritis and optic neuritis with multiple sclerosis. (17375637)
2007
36
An unusual presentation of optic neuritis and the Pulfrich phenomenon. (17635984)
2007
37
Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis. (17987252)
2007
38
Recovery from optic neuritis: an ROI-based analysis of LGN and visual cortical areas. (17472983)
2007
39
Adalimumab-associated optic neuritis. (16527311)
2006
40
Data vs conclusions in the optic neuritis vaccination investigation. (17172627)
2006
41
Overlap of optic neuritis and anterior ischemic optic neuropathy. (12601716)
2003
42
Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis. (11966770)
2002
43
Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. (11953471)
2002
44
Optic neuritis and retinal vasculitis as primary manifestations of systemic lupus erythematosus. (12733176)
2002
45
Lymphocytic infundibulo-neurohypophysitis associated with recurrent optic neuritis. (11360389)
2001
46
Characterization of the mitochondrial genome in childhood multiple sclerosis. II. Multiple sclerosis without optic neuritis and LHON-associated genes. (10029350)
1998
47
Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. (8624683)
1996
48
Bilateral optic neuritis with branch retinal artery occlusion associated with vaccination. (7835178)
1994
49
Optic neuritis following chickenpox in adults. (3723155)
1986
50
Bilateral optic neuritis simulating papilledema. (13016732)
1953

Genetic Variations for Optic Neuritis

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Expression for genes affiliated with Optic Neuritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Optic Neuritis

Search GEO for disease gene expression data for Optic Neuritis.

Pathways for genes affiliated with Optic Neuritis

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37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Optic Neuritis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Optic Neuritis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cerebrosides4410.6MPZ, MBP
2c3bot (154-182)5910.6MOG, MBP
3ono 25065910.5MOG, MBP
4glatiramer acetate44 1111.5MOG, MBP, MPZ, PLP1
5nogo-66 (1-40)5910.5MOG, MBP
6mog (35-55)5910.5MOG, MBP
7plp (139-151)5910.5MOG, MBP
8sulfatide4410.5MBP, MPZ, MAG, PLP1
9ivig4410.4MBP, MAG, LTA
102,3-cyclic nucleotide4410.4PLP1, MAG, MPZ, MBP, MOG
11valine4410.4MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
12nad28 2411.4MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
13opiate4410.4CCR3, GHRH, HCRT
14iron44 2411.4SOD3, MT-ND6, MT-ND1, MT-ND4, MT-ND2
15nadh44 11 2412.3MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-CO3, MT-ND2
16oligonucleotide4410.3MT-ND5, LTA, HCRT, CXCL11, PLP1, AQP4
17cholesterol44 28 11 2413.3SOD3, MPZ, GHRH, LTA, HCRT, PLP1
18methionine4410.3SOD3, MPZ, MT-ND6, MT-ND1, MT-ND5, MT-ND2
19ganglioside4410.3MBP, MPZ, MAG
20dexamethasone44 49 28 1113.2CCR3, GHRH, LTA, HCRT, CXCL11, AQP4
21arginine4410.2SOD3, MBP, MPZ, GHRH, CXCL11, PLP1
22glutamate4410.2MBP, MPZ, GHRH, LTA, HCRT, PLP1
23silver4410.2PLP1, MBP, MOG
24acetylcholine44 49 28 11 2414.2MOG, SOD3, MBP, MAG, LTA, HCRT
25urea44 11 2412.2AQP4, GHRH, SOD3
26glucose4410.2MOG, GHRH, MT-ND1, MT-ND4, MT-CO3, LTA
27threonine4410.2MBP, MT-ND1, MT-ND4, MT-ND5, MT-ND2, MAG
28cyclic amp44 2411.1GHRH, MAG, LTA, HCRT, PLP1
29adenylate4410.1HCRT, GHRH, MBP, SOD3, CCR3
30cysteine4410.1CCR3, SOD3, MBP, MPZ, MAG, RCVRN
31oxygen44 2411.0CCR3, MOG, SOD3, MT-ND6, MT-ND2, LTA
32alanine4410.0CCR3, SOD3, MBP, MT-ND6, MT-ND1, MT-ND5
33tyrosine449.9CCR3, MBP, MPZ, MT-ND6, MAG, LTA
34serine449.9MOG, SOD3, MBP, MPZ, GHRH, MT-ND6
35calcium44 49 11 2412.9CCR3, MOG, GHRH, MAG, LTA, HCRT
36retinoic acid44 2410.8CCR3, MBP, LTA, RCVRN, PLP1, AQP4
37phospholipid449.8MBP, GHRH, RCVRN, PLP1
38lipid449.7MPZ, MBP, SOD3, MOG, CCR3, GHRH

GO Terms for genes affiliated with Optic Neuritis

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16Gene Ontology
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Cellular components related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.3PLP1, MPZ

Biological processes related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077110.2MAG, MBP
2axon ensheathmentGO:00836610.0PLP1, MBP

Molecular functions related to Optic Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP

Products for genes affiliated with Optic Neuritis

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Sources for Optic Neuritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet