MCID: ORL011
MIFTS: 53

Oral Cancer malady

Rare diseases, Oral diseases, Cancer diseases categories

Summaries for Oral Cancer

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44NIH Rare Diseases, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Oral cancer can form in any part of the mouth or throat. most oral cancers begin in the tongue and in the floor of the mouth. anyone can get oral cancer, but the risk is higher if you are male, over age 40, use tobacco or alcohol or have a history of head or neck cancer. frequent sun exposure is also a risk for lip cancer. symptoms of oral cancer include white or red patches in your mouth a mouth sore that won't heal bleeding in your mouth loose teeth problems or pain with swallowing a lump in your neck an earache oral cancer treatments may include surgery, radiation therapy or chemotherapy. some patients have a combination of treatments. nih: national cancer institute

MalaCards: Oral Cancer, also known as lip and oral cavity carcinoma, is related to leukoplakia and cervical cancer. An important gene associated with Oral Cancer is GSTM3 (glutathione S-transferase mu 3 (brain)), and among its related pathways are Estrogen metabolism and 2 Naphthylamine and 2 Nitronaphtalene metabolism. The compounds trans,trans-muconic acid and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and endothelial, and related mouse phenotypes are tumorigenesis and integument.

NIH Rare Diseases:44 Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth). most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. about 35,000 individuals in the united stated are diagnosed with oral cancer each year. the use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy. last updated: 3/9/2010

Wikipedia:66 Oral cancer or mouth cancer, a type of head and neck cancer, is any cancerous tissue growth located in... more...

Aliases & Classifications for Oral Cancer

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Sources:
44NIH Rare Diseases, 46Novoseek, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cancer 44 46 35
lip and oral cavity carcinoma 63


Related Diseases for Oral Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Oral Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia30.9TERC, CYP1A1, KRT13, GSTT1, GSTM1
2cervical cancer29.8TERC, SERPINB3, GSTM1, GSTT1
3prostate cancer29.7TERC, CYP2E1, GSTP1, GSTM1, GSTT1, S100A2
4lung cancer29.5TERC, CTSL, GADD45A, GSTP1, CYP1A1, CYP2E1
5leukemia29.4TERC, CYP2E1, CYP1A1, GADD45A, GSTT1, CTSL
6oral submucous fibrosis10.3
7oral leukoplakia10.3
8oral lichen planus10.3
9lichen planus10.3
10cervicitis10.3
11oral squamous cell carcinoma10.2
12hypoxia10.2
13endotheliitis10.2
14erythroplakia10.1
15paraneoplastic syndromes10.1
16asbestosis10.1GSTM1, GSTT1
17senile cataract10.1GSTT1, GSTM1
18brain cancer10.1CYP1A1, GSTT1, GSTM1
19papilloma10.1
20open-angle glaucoma10.1GSTM1, GSTT1
21acute myeloid leukemia, adult10.1CYP1A1, GSTM1, GSTT1
22aplastic anemia10.1TERC, GSTT1, GSTM1
23gastritis10.1TERC, GSTT1
24pregnancy loss10.1CYP1A1, GSTT1
25endometriosis10.1CYP1A1, GSTM1, GSTT1
26esophageal squamous cell carcinoma10.1CCND1, GSTM1
27gastric adenocarcinoma10.1TERC, GSTT1, GSTM1
28alcoholic pancreatitis10.1ADH1C, CYP2E1
29myelodysplastic syndromes10.1GSTT1, GSTM1, TERC
30alcoholic liver cirrhosis10.0GSTM1, ADH1C, CYP2E1
31pancreatitis, chronic10.0ADH1C, CYP2E1, GSTT1
32infertility10.0CYP1A1, GSTT1, TERC
33basal cell carcinoma10.0S100A2, GSTM1, CYP1A1, GSTT1, GSTM3
34thyroid cancer10.0CCND1, GSTM1, GSTT1
35acute lymphocytic leukemia10.0GSTM1, GSTT1, CYP1A1, GSTP1
36transitional cell carcinoma10.0GSTT1, GSTP1, TERC, GSTM1
37alcohol abuse10.0CYP2E1, ADH1C
38acute leukemia10.0TERC, GSTM1, GSTP1, GSTT1
39liver cirrhosis10.0ADH1C, CYP2E1, TERC
40xeroderma pigmentosum10.0GSTT1, GADD45A, CYP1A1
41psoriasis10.0SERPINB3, CTSL, KRT13, S100A2
42nasopharynx carcinoma10.0CYP2E1, CYP1A1, KRT13, GSTT1, GSTM1
43pancreatitis10.0CYP2E1, ADH1C, GSTP1
44esophageal cancer10.0GSTP1, CCND1, CYP1A1
45lung benign neoplasm10.0TERC, CYP1A1, GSTP1, CTSL
46mucoepidermoid carcinoma10.0
47intellectual disability10.0
48tongue cancer10.0
49mutagen sensitivity10.0
50acute lymphoblastic leukemia, childhood10.0GSTP1, GSTT1, GSTM1, CYP1A1, CYP2E1

Graphical network of the top 20 diseases related to Oral Cancer:



Diseases related to oral cancer

Symptoms for Oral Cancer

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Drugs & Therapeutics for Oral Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Oral Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cancer

Search NIH Clinical Center for Oral Cancer

Search CenterWatch for Oral Cancer

Genetic Tests for Oral Cancer

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Anatomical Context for Oral Cancer

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Sources:
34MalaCards
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MalaCards organs/tissues related to Oral Cancer:

34
Tongue, Lymph node, Endothelial, Lung, Bone, T cells, Salivary gland, Colon, Placenta, Prostate, Testes, Smooth muscle, Skin

Animal Models for Oral Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Oral Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TERC, CYP2E1, CCND1, GSTP1, GADD45A
2MP:00107717.8ANO1, CCND1, GSTP1, GADD45A, CTSL, TERC
3MP:00053767.1CTSL, TERC, CYP1A1, CYP2E1, ADH1C, ANO1
4MP:00053787.0TERC, CYP1A1, ADH1C, ANO1, CCND1, GSTP1
5MP:00107686.9TERC, CYP1A1, CYP2E1, ADH1C, ANO1, CCND1

Publications for Oral Cancer

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Sources:
53PubMed
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Articles related to Oral Cancer:

(show top 50)    (show all 950)
idTitleAuthorsYear
1
Support needs and quality of life in oral cancer: a systematic review. (24034791)
2014
2
Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India. (23444898)
2014
3
Mitochondrial DNA mutations may not be frequent in patients with oral cancer. (24047158)
2013
4
The application of vizilite in oral cancer. (23450083)
2013
5
Oral cancer: from bench to bedside, the continuous effort towards better diagnostic, treatment and prognostic tools. (24212982)
2013
6
Assessing dental students' knowledge of oral cancer in the United Arab Emirates. (23550520)
2013
7
Inflammation in the context of oral cancer. (23910564)
2013
8
The dentist's role within the multi-disciplinary team maintaining quality of life for oral cancer patients in light of recent advances in radiotherapy. (23858630)
2013
9
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
10
Multiple drug resistant, tumorigenic stem-like cells in oral cancer. (23791883)
2013
11
Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. (23378643)
2013
12
Oral cancer screenings. (24357559)
2013
13
Tumour classification for early oral cancer - is the current TNM classification adequate? (24375610)
2013
14
Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy. (23695424)
2013
15
Alterations in serum lipid profile patterns in oral cancer. (24082735)
2013
16
Epidemiology of oral cancer in Asia in the past decade--an update (2000-2012). (24289546)
2013
17
Evaluation of p53 protein as a prognostic factor for oral cancer surgery. (23791033)
2013
18
Barriers to oral cancer screening: a focus group study of rural Black American adults. (22926896)
2013
19
Oral cancer screening. (22529545)
2012
20
Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer. (22341307)
2012
21
Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols. (22817766)
2012
22
Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer. (21472888)
2012
23
Patients' perceptions of oral cancer screening in dental practice: a cross-sectional study. (23249393)
2012
24
Promoting oral cancer awareness and early detection using a mass media approach. (22799308)
2012
25
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 17. Osteonecrosis. (22852516)
2012
26
Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. (22126492)
2011
27
Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. (21840245)
2011
28
Oral cancer-associated paraneoplastic syndromes. (21180290)
2010
29
Alteration in the expression of cdk4 and cdk6 proteins in oral cancer and premalignant lesions. (20618617)
2010
30
CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. (20695076)
2009
31
Association of polymorphisms in Tumor Necrosis Factor Alpha and Beta genes with increased risk for oral cancer. (19528505)
2009
32
A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients. (17933579)
2008
33
Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma. (19048118)
2008
34
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer. (18243718)
2008
35
Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan. (18487076)
2008
36
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. (17325662)
2007
37
Over-expression of 14-3-3zeta is an early event in oral cancer. (17764575)
2007
38
The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. (16886618)
2006
39
Genetic and epigenetic alterations of BRG1 promote oral cancer development. (15586241)
2005
40
Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. (15863273)
2005
41
Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. (14719121)
2004
42
Chemoprevention of oral cancer]. (12822012)
2003
43
No mutations of the Bub1 gene in human gastric and oral cancer cell lines. (12375025)
2002
44
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. (11960911)
2002
45
Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report. (12162763)
2002
46
Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. (11140899)
2001
47
Localization of a novel tumor suppressor gene loci on chromosome 9p21-22 in oral cancer. (10226521)
1999
48
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. (9367063)
1997
49
Lipoxygenase products in human saliva: patients with oral cancer compared to controls. (7744301)
1995
50
Cytokeratin expression in oral cancer and its relationship to tumor differentiation. (7680377)
1993

Variations for Oral Cancer

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Expression for genes affiliated with Oral Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cancer

Search GEO for disease gene expression data for Oral Cancer.

Pathways for genes affiliated with Oral Cancer

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 61Thomson Reuters, 56Reactome, 31KEGG
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Pathways related to Oral Cancer according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1CYP1A1, GSTM1
210.0CYP2E1, CYP1A1
310.0GSTT1, GSTP1
4
Show member pathways
9.9GSTP1, ADH1C
59.8GSTT1, GSTP1, GSTM1
6
Show member pathways
9.8CYP1A1, CYP2E1, ADH1C
79.7CYP1A1, CYP2E1, GSTP1
8
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.6GSTM3, GSTM1, GSTP1, GSTT1
99.4CYP2E1, GSTT1, GSTP1, GSTM1, CYP1A1
10
Show member pathways
8.9GSTT1, CYP1A1, GSTP1, CYP2E1, ADH1C, GSTM3
11
Show member pathways
8.9CYP1A1, CYP2E1, ADH1C, GSTM3, GSTM1, GSTP1
12
Show member pathways
8.7GSTM1, GSTP1, GSTM3, TCN1, GSTT1, CYP2E1

Compounds for genes affiliated with Oral Cancer

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46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Oral Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1trans,trans-muconic acid4610.2CYP2E1, GSTT1, GSTM1
2methylchloride4610.2GSTP1, GSTM1, GSTT1
3butadiene monoxide4610.2CYP2E1, GSTM1, GSTT1
4cumene hydroperoxide4610.1GSTM1, GSTT1, GSTP1
5vinylchloride4610.1GSTM1, CYP2E1, GSTT1
6toluene4610.1GSTT1, GSTM1, CYP2E1
7debrisoquine46 5211.1CYP2E1, CYP1A1, GSTM1
8Estrone-2,3-quinone2510.1GSTP1, GSTT1, GSTM1, GSTM3
94-Hydroxyestrone-2-S-glutathione2510.1GSTM3, GSTM1, GSTP1, GSTT1
102-Hydroxyestrone-4-S-glutathione2510.1GSTM3, GSTP1, GSTT1, GSTM1
11S-(PGJ2)-glutathione2510.0GSTM3, GSTM1, GSTP1, GSTT1
12Estrone-3,4-quinone2510.0GSTM3, GSTM1, GSTP1, GSTT1
132-Hydroxyestrone-1-S-glutathione2510.0GSTM3, GSTM1, GSTP1, GSTT1
141-chloro-24-dinitrobenzene4610.0GSTP1, GSTT1, GSTM1
15noradrenochrome46 2511.0GSTM3, GSTM1, GSTP1, GSTT1
16hydrochloric acid46 2511.0GSTM3, GSTM1, GSTP1, GSTT1
17bpde4610.0GSTM1, CYP1A1, GSTP1, GSTT1
18adrenochrome46 2511.0GSTP1, GSTM3, GSTT1, GSTM1
19mspi4610.0CYP1A1, GSTM1, GSTT1, CYP2E1
20s-phenylmercapturic acid4610.0GSTT1, CYP2E1, GSTP1, GSTM1
211,3-butadiene4610.0GSTP1, CYP2E1, GSTM1, GSTT1
22styrene4610.0CYP2E1, GSTM1, GSTP1, GSTT1
23trichloroethylene4610.0GSTM1, GSTP1, GSTT1, CYP2E1
24hydrocarbons4610.0GSTT1, CYP1A1, GSTM1, GSTP1
25rsai4610.0CYP2E1, ADH1C, GSTT1, GSTM1
26Glutathione25 1211.0GSTM3, GSTM1, GSTP1, GSTT1
27dichloromethane469.9GSTP1, GSTT1, CYP2E1
28benzo(a)pyrene469.9CYP1A1, GSTT1, GSTP1, GSTM1
29sulforaphane469.9CYP1A1, CCND1, GSTM1, GSTP1
30isoniazid46 52 1211.8GSTT1, GSTM1, CYP2E1
311-hydroxypyrene469.8CYP1A1, GSTT1, GSTM1, GSTP1, CYP2E1
32oxaliplatin46 52 1211.8CYP1A1, GSTM1, GSTP1, CYP2E1, GSTT1
33thalidomide46 52 62 1212.7GSTT1, CCND1, CYP2E1, CYP1A1
34phenethyl isothiocyanate3 4610.7CCND1, CYP1A1, GSTP1
35gsts469.6GSTP1, CYP1A1, GSTM3, GSTM1, CYP2E1, GSTT1
36epoxide469.6GSTT1, GSTP1, GSTM1, GSTM3, CYP2E1, CYP1A1
37formaldehyde46 2510.6CYP1A1, ADH1C, GSTT1, CCND1, CYP2E1
38ascorbic acid46 2510.5GSTM1, CYP2E1, GSTP1, GSTT1, CYP1A1
39acetone469.5GSTM1, CYP2E1, GSTT1, GSTP1, CCND1, CYP1A1
40cyclophosphamide46 52 1211.3GSTP1, GSTM1, GSTM3, ADH1C, CYP1A1, GSTT1
41chlorambucil46 1210.3GSTP1, GSTM1, GADD45A
42Water259.2GSTM1, CYP1A1, GSTT1, GSTP1, GSTM3, ADH1C
43curcumin468.9GADD45A, TERC, CYP1A1, CCND1, GSTP1
44doxorubicin46 52 1210.8TERC, GSTP1, GADD45A, GSTT1, GSTM1, CCND1
45thymidylate468.6GSTP1, GSTM1, CCND1, GADD45A
46etoposide46 52 62 1211.5S100A2, TERC, CYP2E1, GSTP1, GSTT1, GADD45A
47estrogen468.5CYP1A1, CCND1, GSTM1, GSTT1, GSTP1, TERC
48h2o2468.1GSTP1, CYP1A1, CYP2E1, S100A2, GADD45A, GSTM1
49retinoic acid46 258.9CTSL, GADD45A, KRT13, GSTP1, CCND1, CYP2E1
50cisplatin46 52 62 1210.4GSTM1, TERC, GADD45A, CYP2E1, CYP1A1, CTSL

GO Terms for genes affiliated with Oral Cancer

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17Gene Ontology
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Biological processes related to Oral Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular detoxification of nitrogen compoundGO:07045810.3GSTM3, GSTM1
2nitrobenzene metabolic processGO:01891610.2GSTM3, GSTM1
3xenobiotic catabolic processGO:04217810.2GSTM1, GSTM3
4drug metabolic processGO:01714410.0CYP2E1, CYP1A1
5glutathione derivative biosynthetic processGO:19016879.9GSTM3, GSTM1, GSTP1, GSTT1
6glutathione metabolic processGO:0067499.8GSTM3, GSTM1, GSTP1, GSTT1
7response to organonitrogen compoundGO:0102439.8CCND1, CYP2E1
8oxidation-reduction processGO:0551149.5GSTT1, CYP2E1, CYP1A1
9response to drugGO:0424939.5CYP1A1, CYP2E1, CCND1, GSTT1
10xenobiotic metabolic processGO:0068059.1GSTT1, GSTP1, GSTM1, GSTM3, ADH1C, CYP2E1
11small molecule metabolic processGO:0442818.9CYP1A1, CYP2E1, ADH1C, TCN1, GSTM3, GSTM1

Molecular functions related to Oral Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:04329510.1GSTM1, GSTM3
2glutathione transferase activityGO:0043649.5GSTT1, GSTP1, GSTM1, GSTM3
3enzyme bindingGO:0198999.1CYP1A1, CYP2E1, CCND1, GSTM3, GSTM1

Products for genes affiliated with Oral Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cancer

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet