Oral Cancer malady

MedlinePlus: Oral cancer can form in any part of the mouth or throat. most oral cancers begin in the tongue and in the floor of the mouth. anyone can get oral cancer, but the risk is higher if you are male, over age 40, use tobacco or alcohol or have a history of head or neck cancer. frequent sun exposure is also a risk for lip cancer. symptoms of oral cancer include white or red patches in your mouth a mouth sore that won't heal bleeding in your mouth loose teeth problems or pain with swallowing a lump in your neck an earache oral cancer treatments may include surgery, radiation therapy or chemotherapy. some patients have a combination of treatments. nih: national cancer institute²³

MalaCards: Oral Cancer, also known as lip and oral cavity carcinoma, is related to carcinoma and leukoplakia. An important gene associated with Oral Cancer is CDK2AP1 (cyclin-dependent kinase 2 associated protein 1), and among its related pathways are Cell Cycle / Checkpoint Control and Small cell lung cancer. The compounds progesterone and lipid have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and tongue, and related mouse phenotypes are hematopoietic system and nervous system.

NIH Rare Diseases: Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth). Most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. About 35,000 individuals in the United Stated are diagnosed with oral cancer each year. The use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. Treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy.³⁰

Wikipedia: Oral cancer is a subtype of head and neck cancer, is any cancerous tissue growth located in the oral...⁴⁴ more...

oral cancer 30 8 32 23 lip and oral cavity carcinoma 43

Diseases related to oral cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 872)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	39.3	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP4
2	leukoplakia	35.5	PCNA, NAT2, BRCA1, RARA, RARB, BCL2
3	prostatitis	34.6	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP4
4	cervicitis	34.4	RECK, SFN, SFRP1, SFRP2, PCNA, RB1
5	oral squamous cell carcinoma	34.3	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP5
6	squamous cell carcinoma	33.3	SERPINB3, CDH1, MMP10, MMP12, MMP7, MKI67
7	tongue cancer	32.5	PCNA, SERPINB5, VIM, VHL, VEGFA, MYC
8	cervical cancer	31.3	SFN, SFRP1, SFRP2, PCNA, RB1, SERPINB3
9	hypoxia	30.6	PIM1, KLF2, RECK, SFRP1, PCNA, RB1
10	verrucous carcinoma	30.5	PCNA, RB1, CDKN1A, CDKN2A, CDH1, MDM2
11	neuronitis	30.1	PIM1, RECK, SFN, SFRP1, SFRP4, PCNA
12	oral submucous fibrosis	29.8	PCNA, BIRC5, MMP1, MMP2, MMP3, GSTM1
13	fibrosis	29.5	RECK, SFRP4, PCNA, SERPINB3, SETD2, SERPINE1
14	oral lichen planus	29.4	BAX, MMP1, IL1A, ICAM1, HSPA4, HSPA8
15	colorectal cancer	29.2	NAT2, MYCL1, MTHFR, XRCC5, MLH1, GSTM1
16	ataxia	28.6	PCBP2, PCNA, BTG3, SETD2, SERPINE1, VIM
17	paraneoplastic syndromes	28.4	SFRP4, CD79A, GSR, MEPE, IL6, ALB
18	fanconi's anemia	28.2	PCNA, RB1, BRCA1, BRCA2, RAD51, PARP1
19	ataxia telangiectasia	27.9	PCNA, VIM, BRCA1, BRCA2, MYC, RAD51
20	anemia	26.3	PIM1, KLF2, PCNA, RB1, SETD2, BRCA1
21	thrombosis	25.5	RECK, PCNA, SETD2, SERPINE1, VHL, VEGFA
22	homocysteine	25.2	PCNA, SETD2, SERPINE1, NAT2, VHL, VEGFA
23	lung carcinoma	18.8	RECK, PCNA, BUB1, RB1, SERPINB3, SETD2
24	adenocarcinoma	16.6	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP4
25	pancreatitis	16.6	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP4
26	laryngeal squamous cell carcinoma	16.2	PIM1, SFN, PCNA, RB1, NAT2, VEGFA
27	boomerang dysplasia	16.1	PCNA, RB1, SERPINB5, BRCA1, VHL, MYC
28	bartter disease	16.0	PCNA, RB1, SERPINB3, SETD2, SERPINB5, BRCA1
29	esophagitis	15.9	PIM1, RECK, SFN, SFRP1, SFRP2, SFRP4
30	esophageal squamous cell carcinoma	15.8	PIM1, RECK, SFN, PCNA, RB1, SERPINB3
31	gastric cancer	15.8	PIM1, RECK, SFRP1, SFRP2, SFRP5, PCBP2
32	rectal cloacogenic carcinoma	15.8	RECK, PCNA, RB1, NAT2, VEGFC, BIRC5
33	leukemia	15.6	PIM1, KLF2, RECK, SFN, SFRP1, SFRP2
34	lung benign neoplasm	15.6	RB1, RARA, RARB, KDR, LGALS3BP, XRCC1
35	b-cell lymphomas	15.5	PIM1, RB1, MYC, BIRC5, PARP1, BCL2
36	keratosis	15.5	PCNA, RB1, MYC, BCL2, MTAP, S100A2
37	lung adenocarcinoma	15.4	RB1, SETD2, VEGFA, VEGFC, RARB, BIRC5
38	xeroderma pigmentosum	15.3	PCNA, BRCA1, PARP1, BCL2, BAX, XRCC1
39	acute lymphoblastic leukemia, childhood	15.3	RARB, PARP1, LEPR, BAX, MTAP, MTHFR
40	ovarian cancer	15.3	RB1, BRCA1, BRCA2, CDK6, CDKN1A, CDK2
41	medulloblastoma	15.2	SFRP1, SFRP2, PCNA, RB1, VIM, NANOG
42	basal cell carcinoma	15.2	RARA, BCL2, BAK1, BAX, LAMC2, XRCC1
43	squamous cell carcinoma of the head and neck	15.2	RB1, SETD2, VEGFA, VEGFC, MYC, RARA
44	male germ cell tumor	15.1	CDKN1A, CDK2, CDKN2A, CDK1, MGMT, FGF4
45	laryngitis	15.1	PIM1, SFN, PCNA, RB1, SERPINB3, SETD2
46	intrahepatic cholangiocarcinoma	15.1	SFN, RB1, SERPINB5, VEGFC, RARA, BIRC5
47	breast cancer	15.1	RECK, SFRP2, SERPINB5, BRCA1, BRCA2, MYC
48	laryngeal cancer	15.0	PCNA, RB1, SERPINB3, NAT2, BRCA1, VEGFA
49	pancreatic endocrine tumors	15.0	VHL, VEGFC, RARB, BCL2, CDKN1B, CDKN2A
50	skin cancer	15.0	PCNA, VIM, BRCA1, BRCA2, BIRC5, BCL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to oral cancer:

²²

MGI Mouse Phenotypes related to oral cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	13.7	PIM1, KLF13, KLF2, SFN, SFRP1, PCNA
2	nervous system phenotype	MP:0003631	13.5	RECK, SFRP1, SFRP2, SFRP5, RB1, BRCA1
3	mortality/aging	MP:0010768	13.2	KLF2, RECK, SFN, SFRP1, SFRP2, SFRP4
4	growth/size phenotype	MP:0005378	12.8	PIM1, KLF2, RECK, SFN, SFRP1, SFRP2
5	renal/urinary system phenotype	MP:0005367	12.3	SFRP4, BRCA1, VHL, RARA, RARB, BCL2
6	immune system phenotype	MP:0005387	12.0	KLF13, KLF2, SFN, SFRP1, BUB1, VIM
7	embryogenesis phenotype	MP:0005380	12.0	KLF2, RECK, SFN, SFRP1, SFRP2, SFRP5
8	craniofacial phenotype	MP:0005382	11.7	KLF2, XRCC2, XRCC4, XPA, APAF1, IGF1R
9	skeleton phenotype	MP:0005390	11.7	KLF2, RECK, SFN, SFRP1, RB1, BRCA1
10	integument phenotype	MP:0010771	11.3	RECK, SFN, RB1, BRCA1, BRCA2, VHL
11	cellular phenotype	MP:0005384	11.2	PIM1, KLF13, KLF2, SFN, SFRP2, PCNA
12	hearing/vestibular/ear phenotype	MP:0005377	11.2	SFN, RB1, MYC, RARA, RARB, PARP1
13	endocrine/exocrine gland phenotype	MP:0005379	11.0	SFN, SFRP2, SFRP5, BUB1, BRCA1, BRCA2
14	respiratory system phenotype	MP:0005388	11.0	KLF2, SFRP4, BRCA1, LEPR, ITGB3, CCR2
15	behavior/neurological phenotype	MP:0005386	10.9	RB1, VIM, BRCA2, RARB, USF2, USF1
16	other phenotype	MP:0005395	10.9	RECK, BUB1, RARA, RARB, KDR, LEPR
17	homeostasis/metabolism phenotype	MP:0005376	10.9	KLF2, SFRP1, SFRP2, SFRP4, BUB1, RB1
18	liver/biliary system phenotype	MP:0005370	10.8	KLF2, RECK, SFN, BUB1, VHL, VEGFA
19	tumorigenesis	MP:0002006	10.8	SFN, BUB1, BTG3, RB1, SERPINE1, BRCA1
20	digestive/alimentary phenotype	MP:0005381	10.6	SFN, SFRP4, RB1, BRCA1, BRCA2, VHL
21	normal phenotype	MP:0002873	10.6	KLF2, SFRP2, SFRP5, BUB1, BRCA1, BRCA2
22	pigmentation phenotype	MP:0001186	10.5	RB1, BRCA1, MYC, USF2, BCL2, LEP
23	limbs/digits/tail phenotype	MP:0005371	10.4	RECK, SFN, SFRP1, SFRP2, SFRP5, RB1
24	no phenotypic analysis	MP:0003012	10.3	SFRP1, SFRP2, PCNA, BUB1, RB1, NANOG
25	reproductive system phenotype	MP:0005389	10.2	SFN, SFRP2, SFRP4, SFRP5, BUB1, BRCA1
26	vision/eye phenotype	MP:0005391	10.0	SFN, RB1, VIM, VEGFA, RARA, RARB
27	cardiovascular system phenotype	MP:0005385	9.2	KLF2, RECK, SFRP1, SFRP2, SFRP4, RB1
28	adipose tissue phenotype	MP:0005375	9.2	SFRP1, RB1, SERPINE1, BRCA1, MYC, BCL2
29	muscle phenotype	MP:0005369	8.1	KLF2, SFRP2, RB1, VIM, BRCA1, VHL

Articles related to oral cancer:

(show top 50)    (show all 384)

id	Title	Authors	Year	Affiliating Genes
1	Impact of uPA system gene polymorphisms on the suscep tibility of environmental factors to carcinogenesis and the development of clin icopathology of oral cancer. (21125336)	Weng C.J.... Yang S.F.	2011	SERPINE1
2	Alteration in the expression of cdk4 and cdk6 protein s in oral cancer and premalignant lesions. (20618617)	Poomsawat S.... Punyasingh J.	2010	CDK4, CDK6
3	Clinical significance of phosphatidyl inositol syntha se overexpression in oral cancer. (20426864)	Kaur J.... Ralhan R.	2010	CDIPT
4	Diagnostic clinical aids in oral cancer. (20371204)	Seoane LestA^n J.... Diz Dios P.	2010	ANXA1
5	Overexpression of KLF13 and FGFR3 in oral cancer cell s. (20539070)	Henson B.J.... Gollin S.M.	2010	FGFR3, KLF13
6	The genomics of oral cancer and wound healing. (19414966)	Aswini Y.B.	2009	CYP1A1
7	Human oral cancers have altered expression of Bcl-2 family members and increased expression of the anti-apoptotic splice variant of Mcl-1. (19009587)	Mallick S.... Teni T.R.	2009	MCL1
8	ORAOV1-A correlates with poor differentiation in oral cancer. (19493886)	Jiang L.... Chen Q.M.	2009	ORAOV1
9	Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. (19681038)	Joseph M.J.... Munshi H.G.	2009	TGFB1, MMP9, SNAI2
10	Transforming growth factor-beta 1 promotes matrix metalloproteinase-9-mediated oral cancer invasion through snail expression. (18234959)	Sun L.... Munshi H.G.	2008	MMP9, ETS1, SNAI1
11	Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. (18381414)	Kozaki K.... Inazawa J.	2008	E2F6
12	A DNA polymorphism of stromal-derived factor-1 is associated with advanced stages of oral cancer. (18383856)	Vairaktaris E.... Patsouris E.	2008	CXCL12
13	Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. (17487405)	Murakami J.... Matsubara N.	2007	MGMT
14	Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. (17461521)	Cha I.H.... Park K.K.	2007	CYP1A1, GSTM1
15	Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. (17630775)	Tsuji T.... Hu G.F.	2007	RPS27A, OAZ1
16	Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines. (17786320)	Brady G.... Kapas S.	2007	IGF1R, IGF2
17	Butyrate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2. (17595767)	Miki Y.... Komiyama K.	2007	PTGS2
18	HnRNP E2 is downregulated in human oral cancer cells and the overexpression of hnRNP E2 induces apoptosis. (17219427)	Roychoudhury P.... Chaudhuri K.	2007	PCBP2
19	Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer. (16324877)	Ramachandran S.... Radhakrishna Pillai M.	2006	ERCC2, XRCC1
20	Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. (17060937)	Siriwardena B.S.... Takata T.	2006	POSTN
21	CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study. (17160265)	Leichsenring A.... Ribeiro E.M.	2006	GSTP1, CYP1A1
22	High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis. (16967447)	Chien C.Y.... Huang C.C.	2006	VEGFA, ENG
23	Strong association of interleukin-6 -174 G>C promoter polymorphism with increased risk of oral cancer. (17177164)	Vairaktaris E.... Patsouris E.	2006	IL6
24	Expression and significance of fragile histidine triad in oral cancer and precancerous lesions (15897145)	Yin C.... Yao X.	2005	FHIT
25	Interleukin-4 gene, but not the interleukin-1 beta gene polymorphism, is associated with oral cancer. (15900573)	Tsai M.H.... Tsai F.J.	2005	IL1B, IL4
26	Risk assessment of p53 genotypes and haplotypes in tobacco-associated leukoplakia and oral cancer patients from eastern Idia. (15981211)	Mitra S.... Roychoudhury S.	2005	TP53
27	The role of COX-2 in oral cancer development, and chemoprevention/ treatment of oral cancer by selective COX-2 inhibitors. (15892674)	Wang Z.	2005	PTGS2
28	Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (15791567)	Odajima T.... Sawada N.	2005	EGFR, CCND1, CTNNB1
29	Oral cancer prevention and the evolution of molecular-targeted drug development. (15637397)	Lippman S.M.... Hong W.K.	2005	TP53, CCND1, RARB
30	Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. (14719121)	Han S.E.... Min B.M.	2004	CAV1
31	Novel management of oral cancer: a paradigm of predictive oncology. (15931363)	SudbA... J.	2004	CCND1
32	2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity. (15551755)	Takata H.... Matsui H.	2004	TP53
33	Effect of 5-fluorouracil on G1 phase cell cycle regul ation in oral cancer cell lines. (14662417)	Li M.H.... Nagumo M.	2004	CDKN1A
34	Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. (15509494)	Curino A.... Bugge T.H.	2004	PLAU, SERPINE1
35	Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival. (15312688)	Farhadieh R.D.... Jacobson I.V.	2004	CD82
36	RT-PCR amplification of RNA extracted from formalin-fixed, paraffin-embedded oral cancer sections: analysis of p53 pathway. (12926130)	Tachibana M.... Fujimori T.	2003	TP53, GAPDH, ING1
37	The p53 codon 72 polymorphism and risk of oral cancer in Southern Thailand. (14507241)	Kietthubthew S.... Ishida T.	2003	TP53
38	Combined preoperative therapy for oral cancer with n edaplatin and radiation (11915741)	Adachi M.... Suzuki M.	2002	CSF3
39	Expression of telomerase RNA in oesophageal and oral cancer. (11722706)	Downey M.G.... Keith W.N.	2001	TERC
40	Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. (11140899)	Sumitani K.... Nagumo M.	2001	PTGS2
41	Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus. (11259088)	Yamamoto N.... Tanzawa H.	2001	BTG3
42	Expression of heparanase in oral cancer cell lines and oral cancer tissues. (11167146)	Ikuta M.... Yanagishita M.	2001	HPSE
43	Proliferative and apoptotic responses in cancers with special reference to oral cancer. (10759427)	Kamer A.R.... Liebow C.	1999	CDKN3
44	Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines. (10389982)	Sartor M.... Tavassoli M.	1999	RB1, CCND1
45	Focal adhesion kinase expression in oral cancers. (9744465)	Kornberg L.J.	1998	PTK2
46	Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer. (9413357)	Sewell D.A.... O'malley B.W.	1997	TKT
47	p53 immunostaining as a marker for oral cancer in diagnostic cytopathology--preliminary report. (8173031)	Ogden G.R.... Lane D.P.	1994	TP53
48	Loss of heterozygosity of p53 in oral cancers demonstrated by the polymerase chain reaction. (8443743)	Largey J.S.... Archibald D.W.	1993	TP53
49	Cellular sources of transforming growth factor-alpha in human oral cancer. (2022775)	Todd R.... Wong D.T.	1991	TGFA
50	Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c- myc. (2654810)	Tadokoro K.... Tsuchida N.	1989	HRAS

Genes related to oral cancer according to GeneCards:

(show top 50)    (show all 350)

id	Symbol	Description	Score	GeneCards Section Context
1	CDK2AP1	cyclin-dependent kinase 2 associated protein 1	11.1	Orthologs, Publications, Aliases & Descriptions
2	ORAOV1	oral cancer overexpressed 1	11.1	Aliases & Descriptions, Proteins, UniProt Related, Publications (show all 6 sections) Transcripts, Orthologs
3	CDK2AP2	cyclin-dependent kinase 2 associated protein 2	11.1	Orthologs, Aliases & Descriptions
4	ORAOV1P1	oral cancer overexpressed 1 pseudogene 1	11.0	Aliases & Descriptions
5	ANO1	anoctamin 1, calcium activated chloride channel	11.0	Publications, Aliases & Descriptions
6	PIM1	pim-1 oncogene	11.0	Summaries
7	GSTM3	glutathione S-transferase mu 3 (brain)	11.0	Publications
8	KRT13	keratin 13	11.0	Publications
9	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
10	S100A2	S100 calcium binding protein A2	11.0	Publications
11	TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	11.0	Publications
12	CTSL1	cathepsin L1	11.0	Publications
13	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	11.0	Publications
14	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
15	GSTM1	glutathione S-transferase mu 1	11.0	Publications
16	TERC	telomerase RNA component	11.0	Publications
17	ANXA1	annexin A1	11.0	Publications
18	CCNA2	cyclin A2	11.0	Publications
19	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0
20	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
21	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0
22	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
23	CD82	CD82 molecule	11.0	Publications
24	GSTT1	glutathione S-transferase theta 1	11.0	Publications
25	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications
26	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
27	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
28	RARB	retinoic acid receptor, beta	11.0	Publications
29	CDK4	cyclin-dependent kinase 4	11.0	Publications
30	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
31	GSTP1	glutathione S-transferase pi 1	11.0	Publications
32	PLAU	plasminogen activator, urokinase	11.0	Publications
33	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
34	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
35	ENG	endoglin	11.0	Publications
36	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
37	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0	Publications
38	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
39	KRT5	keratin 5	11.0
40	KRT14	keratin 14	11.0
41	CTSB	cathepsin B	11.0	Publications
42	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.0	Publications
43	IVL	involucrin	11.0
44	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
45	VEGFC	vascular endothelial growth factor C	11.0	Publications
46	CCND1	cyclin D1	11.0	Publications
47	CAT	catalase	11.0	Publications
48	TNC	tenascin C	11.0	Publications
49	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	11.0	Publications
50	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.0	Publications

Pathways related to oral cancer according to GeneDecks:

(show top 50)    (show all 254)

id	Pathway	Score	Top Affiliating Genes
1	Cell Cycle / Checkpoint Control3	11.9	PCNA, RB1, BRCA1, BRCA2, RAD51, CHEK1
2	Small cell lung cancer20	11.7	RB1, MYC, RARB, BCL2, LAMC2, CDK6
3	p53 signaling pathway20	11.7	SFN, SERPINB5, SERPINE1, CHEK1, BAX, ATM
4	Apoptosis and Autophagy3	11.6	PIM1, SERPINB5, BNIP3L, MYC, BIRC5, PARP1
5	Cell cycle20	11.5	SFN, PCNA, BUB1, RB1, MYC, CHEK1
6	Glioma Invasiveness36	11.2	VEGFC, ITGAV, ITGB1, ITGB6, FGF4, PTK2
7	Glioblastoma Multiforme36	11.1	RB1, CDK6, CDKN1A, CDK2, CDKN1B, CDK4
8	Apoptosis Signaling Pathways37	11.1	SFN, BIRC5, BCL2, YWHAZ, BAK1, BAX
9	PTEN Pathway36	11.1	VEGFC, KDR, LAMC2, ITGA2, ITGB6, FN1
10	Cell adhesion ECM remodeling10	11.1	SERPINE1, LAMC2, ITGB1, MMP1, MMP10, MMP12
11	p53 Signaling36	11.1	SFN, BRCA1, BCL2, CHEK1, BAX, ATM
12	Cell adhesion_ECM remodeling41	11.1	SERPINE1, LAMC2, ITGB1, MMP1, MMP10, MMP12
13	G1-S Phase Transition36	11.0	RB1, ATM, CDK6, CDKN1A, CDK2, CDKN2B
14	Signal transduction_PTEN pathway41	11.0	PCNA, ITGB1, IGF1R, CASP9
15	Angiogenesis3	11.0	RECK, SERPINB5, VHL, VEGFC, KDR, ITGAV
16	Melanoma20	11.0	RB1, CDK6, CDKN1A, CDKN2A, CDK4, CDH1
17	Apoptosis20	10.8	BCL2, BAX, ATM, IL1A, IL1B, APAF1
18	Ceramide Pathway36	10.8	JUN, JUNB, JUND, FOS, FOSB, FOSL1
19	Molecular Mechanisms of Cancer36	10.8	RB1, BRCA1, VEGFC, MYC, RARA, RARB
20	Pancreatic cancer20	10.8	BRCA2, CDK6
21	Measles20	10.7	FYN, CDK6, CDK2, CDKN1B, CDK4, IL1A
22	Glioma20	10.4	RB1, CDK6, CDKN1A, CDKN2A, CDK4, MDM2
23	Akt Signaling36	10.4	VEGFC, CHEK1, ITGA2, ITGB6, FGF4, FGFR3
24	Pancreatic Adenocarcinoma36	10.4	RB1, BRCA2, VEGFC, BIRC5, KDR, BCL2
25	Bladder cancer20	10.2	RB1, VEGFA, VEGFC, MYC, CDKN1A, CDKN2A
26	Colorectal Cancer Metastasis36	10.2	MYC, BIRC5, BAX, CDKN1A, CDH1, MMP1
27	Immune response_Oncostatin M signaling via MAPK in human cells41	10.2	LDLR, JUN, JUNB, JUND, MMP1, MMP13
28	Non-small cell lung cancer20	10.2	RB1, CDK6, CDKN2A, CDK4, FHIT, MAPK1
29	Prostate cancer20	10.1	RB1, BCL2, CDKN1A, CDK2, CDKN1B, GSTP1
30	Mitochondrial Apoptosis36	10.1	VEGFC, KDR, BCL2, BAK1, BAX, ATM
31	DHA Signaling36	10.1	VEGFC, KDR, BCL2, YWHAZ, BAX, FGF4
32	Immune response Oncostatin M signaling via MAPK in human cells10	10.0	JUN, JUNB, JUND, MMP1, MMP13, MMP3
33	Immune response IL-1 signaling pathway10	9.9	SERPINE1, JUN, JUNB, JUND, FOS, FOSB
34	PPAR Pathway36	9.9	VEGFC, ITGA2, ITGAV, ITGB1, ITGB3, ITGB6
35	Cellular Apoptosis Pathway36	9.9	VEGFC, KDR, BCL2, BAK1, BAX, ATM
36	Immune response_IL-1 signaling pathway41	9.9	SERPINE1, JUN, JUNB, JUND, FOS, FOSB
37	14-3-3 Induced Apoptosis36	9.8	BCL2, YWHAZ, JUN, FOS, IL1A, IL1B
38	Development_VEGF signaling via VEGFR2 - generic cascades41	9.8	VEGFA, FYN, JUN, ITGAV, ITGB3, FOS
39	Focal adhesion20	9.5	VEGFC, KDR, BCL2, LAMC2, FYN, JUN
40	STAT3 Pathway36	9.3	PIM1, MYC, BCL2, BAX, CDKN1A, IL10
41	PAK Pathway36	9.2	VEGFC, KDR, BCL2, BAX, FGF4, FGFR3
42	Phospholipase-C Pathway36	9.1	VEGFC, KDR, LAMC2, FYN, CD79A, ITGA2
43	MIF Regulation of Innate Immune Cells36	9.1	BCL2, BAX, JUN, FOS, IL10, IL18
44	Glucocorticoid Receptor Signaling36	8.9	BCL2, BAX, JUN, CDKN1A, FOS, IL10
45	TGF-Beta Pathway36	8.9	VEGFC, KDR, BCL2, BAX, JUN, CDH1
46	Rho Family GTPases36	8.8	VIM, VEGFC, KDR, BCL2, BAX, LAMC2
47	p38 Signaling36	8.8	VEGFC, KDR, BCL2, BAX, JUNB, JUND
48	14-3-3 Induced Intracellular Signaling36	8.7	VEGFC, YWHAZ, JUN, FGF4, FGFR3, MAPK3
49	Tec Kinases Signaling36	8.4	VEGFC, BCL2, BAX, ITGA2, ITGAV, ITGB1
50	JAK-STAT Pathway36	7.6	BRCA1, VEGFC, MYC, KDR, BCL2, BAX

Compounds related to oral cancer according to GeneDecks:

(show top 50)    (show all 505)

id	Compound	Score	Top Affiliating Genes
1	progesterone32 42 9 18 9	17.3	SFRP4, PCNA, RB1, SETD2, SERPINB5, BRCA1
2	lipid32	12.8	RECK, RB1, SETD2, SERPINB5, SERPINE1, VIM
3	estrogen32	12.1	PCNA, SETD2, SERPINB5, SERPINE1, NAT2, BRCA1
4	doxorubicin32 34 9 9	14.7	RECK, SETD2, VIM, BRCA1, PARP1, KDR
5	vegf32	11.7	RECK, PCNA, SETD2, SERPINB5, SERPINE1, BRCA1
6	threonine32	11.7	MT-ND2, XRCC5, AURKB, CDK6, CDKN2B, CDKN1B
7	quercetin32 42 9 18 9	15.5	PIM1, BIRC5, PARP1, BCL2, BAK1, BAX
8	pge232	11.4	SETD2, LDLR, JUNB, CDH1, IVL, MMP1
9	agarose32	11.2	BRCA1, MYC, PARP1, BCL2, BAX, CDKN1A
10	flavopiridol32 9 9	13.2	RB1, VEGFA, BIRC5, PARP1, BCL2, BAK1
11	methylmethanesulfonate32	11.1	PCNA, BRCA1, BRCA2, RAD51, PARP1, CHEK1
12	paclitaxel32 34 9 9	14.0	PCNA, BUB1, RB1, SETD2, VIM, BRCA1
13	silymarin32	11.0	PCNA, VEGFA, BIRC5, PARP1, JUN, CDK6
14	olomoucine32 42 9 9	14.0	PCNA, RB1, BCL2, BAX, CDKN1A, CDK2
15	formaldehyde32 18	11.9	PCNA, RB1, VIM, B2M, CD79A, CDKN1B
16	glycerol32 9 18 9	13.9	PCNA, NAGA, BRCA1, LEP, CD79A, CDK2
17	aphidicolin32	10.9	PCNA, RB1, BRCA1, MYC, RAD51, CHEK1
18	mannitol32 9 9	12.8	SERPINE1, B2M, CDIPT, CDKN3, CDH1, IVL
19	aprotinin32 9 9	12.8	MMP13, MMP2, MMP9, FN1, IL1A, GP1BA
20	sb 20358032 42	11.8	RB1, SETD2, VIM, VEGFA, BNIP3, BIRC5
21	butyrate32	10.8	PCNA, RB1, SETD2, VIM, MYC, RARA
22	parthenolide32	10.8	MMP9, IL6, FASLG, MAPK10, IFNG, ICAM1
23	p00332	10.7	RB1, SERPINE1, BRCA1, BRCA2, LEP, XRCC3
24	4-hydroxynonenal32 18	11.7	MYC, PARP1, BAX, JUN, CDK2, MMP1
25	carbon32	10.6	PCNA, NAGA, LDLR, MTHFR, CEACAM3, FUCA1
26	thapsigargin32 42	11.6	PCNA, SERPINE1, BCL2, BAK1, CDKN3, IVL
27	z-vad-fmk32 42	11.5	PARP1, BCL2, BAX, ANXA5, CASP3, CASP4
28	phosphatidylserine32 9 9	12.4	RECK, VIM, PARP1, BCL2, BAK1, CD79A
29	genistein32 9 18 9	13.4	PCNA, RB1, SETD2, SERPINE1, VIM, BRCA1
30	adenine32 9 18 9	13.4	SETD2, NAT2, BRCA1, RAD51, LEP, LDLR
31	zoledronic acid32	10.4	PARP1, MMP9, ANXA5, IBSP, ALPP, CASP6
32	forskolin32 42 9 9	13.4	VIM, RARB, JUN, JUNB, CDKN1B, IVL
33	cyclosporin a32 42	11.3	RECK, MYC, LEP, LDLR, MTHFR, B2M
34	citrate32	10.1	MT-CO3, CD79A, CDKN3, MKI67, HSPB1, HSP90AA1
35	gf 109203x32 42	11.1	VEGFA, JUN, CDKN1A, CDKN3, IVL, MMP1
36	phenethyl isothiocyanate32	10.1	MYC, PARP1, BCL2, BAX, JUN, GSTP1
37	chloroquine32 34 9 9	13.0	BRCA1, LDLR, B2M, CD79A, CDH1, GSR
38	gefitinib32 34 9 9	12.9	VIM, VEGFA, RAD51, BIRC5, KDR, CDK6
39	wortmannin32 42	10.9	SETD2, VIM, RAD51, BIRC5, KDR, BCL2
40	heparin32 9 18 9	12.9	RECK, SFRP1, SERPINE1, VIM, BRCA1, VEGFC
41	docetaxel32 34 9 9	12.9	SETD2, BRCA1, BRCA2, VEGFA, MYC, BIRC5
42	atorvastatin32 34 9 18 9	13.8	VEGFA, LDLR, MMP1, MMP2, MMP9, IL10
43	thalidomide32 42 9 9	12.7	VEGFA, BIRC5, KDR, B2M, FGFR3, IL10
44	methotrexate32 34 42 9 9	13.4	PCNA, RB1, SERPINE1, VIM, NAT2, BRCA1
45	simvastatin32 34 42 9 18 9	14.4	SERPINE1, VEGFA, KDR, LDLR, MMP3, MMP9
46	suramin32 9 9	11.3	RECK, PCNA, VEGFA, KDR, LDLR, CD79A
47	erlotinib32 34 9 9	12.2	VEGFA, BIRC5, KDR, CDKN1B, CDKN3, CDH1
48	dexamethasone32 42 34 9 9	13.2	PCNA, RB1, SERPINE1, VIM, NAT2, VEGFA
49	infliximab32 9 9	10.8	VEGFA, BAK1, MMP1, MMP3, IL10, IL18
50	triptolide32	8.6	VEGFA, PARP1, BCL2, BAX, JUN, MMP3

Cellular components related to oral cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	13.1	GADD45A, GAPDH, EP300, HSPA4, TP53, TP63
2	cytoplasm	GO:005737	12.4	RRM2B, SLC7A8, NPM1, POU5F1, WIBG, ECT2
3	nucleoplasm	GO:005654	11.8	YWHAZ, XRCC1, XRCC4, XRCC5, XRCC6, XPA
4	cytosol	GO:005829	11.6	CCR2, CAV1, CASP9, GMPS, HRAS, AKR1A1
5	proteinaceous extracellular matrix	GO:005578	10.8	MMP7, MMP3, MMP13, MMP12, MMP11, MMP10
6	cell surface	GO:009986	10.0	CAV1, HSPA8, HSPB1, ALPP, ENG, IL1A
7	external side of plasma membrane	GO:009897	9.4	FASLG, FAS, ENG, ANXA5, IFNG, IL4
8	extracellular region	GO:005576	9.1	IGF2, MMP9, MMP7, MMP3, MMP2, MMP13
9	platelet alpha granule lumen	GO:031093	9.0	KNG1, VEGFC, TGFB1, EGF, ALB, VEGFA
10	extracellular space	GO:005615	8.5	SFRP1, IL1B, IL4, IL6, FASLG, ENG

Biological processes related to oral cancer according to GeneDecks:

(show top 50)    (show all 65)

id	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:006508	11.6	VHL, LGMN, LCN1, MMP1, MMP10, MMP11
2	extracellular matrix disassembly	GO:022617	11.6	MMP1, MMP10, MMP11, MMP13, MMP2, MMP3
3	DNA repair	GO:006281	11.5	PCNA, BRCA1, BRCA2, RAD51, PARP1, CHEK1
4	extracellular matrix organization	GO:030198	11.5	RECK, SERPINB5, MMP1, MMP10, MMP11, MMP13
5	G1/S transition of mitotic cell cycle	GO:000082	11.5	PCNA, RB1, BCL2, CDK6, CDKN1A, CDK2
6	glutathione metabolic process	GO:006749	11.2	GSR, GSTA1, GSTA2, GSTA3, GSTA4, GSTM3
7	response to hyperoxia	GO:055093	11.1	SERPINE1, BNIP3, CDKN1A, MMP9, IL18, ALOX5
8	fibrinolysis	GO:042730	11.1	SERPINE1, GP1BA, F2, F12, PLAU, PLAUR
9	cell cycle checkpoint	GO:000075	11.0	RB1, CHEK1, ATM, CDKN1A, CDK2, CDKN1B
10	response to toxin	GO:009636	11.0	BCL2, BAX, XPA, CDKN1A, CDK1, CDH1
11	induction of apoptosis by intracellular signals	GO:008629	11.0	BNIP3, MYC, BCL2, BAK1, BAX, CDKN1A
12	response to organic cyclic compound	GO:014070	10.9	SFRP1, BAK1, JUN, JUNB, CDKN1A, CDK1
13	positive regulation of apoptotic process	GO:043065	10.8	SFRP1, SFRP2, SFRP4, RARB, BAK1, BAX
14	release of cytochrome c from mitochondria	GO:001836	10.8	SFN, MYC, BCL2, BAK1, BAX, JUN
15	neuron apoptotic process	GO:051402	10.8	RB1, BNIP3, BCL2, BAX, ATM, FAS
16	response to gamma radiation	GO:010332	10.8	BRCA2, MYC, BCL2, BAK1, BAX, XRCC2
17	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.7	MYC, BAX, CDKN1B, CDKN2A, APAF1, FASLG
18	signal transduction	GO:007165	10.6	SFN, SFRP5, VEGFC, RARA, RARB, LGALS3BP
19	cellular response to hypoxia	GO:071456	10.6	SFRP1, VHL, VEGFA, BNIP3, MDM2, ICAM1
20	induction of apoptosis	GO:006917	10.6	BNIP3, BNIP3L, BAX, CDKN1B, CDKN2A, FASLG
21	apoptotic process	GO:006915	10.6	PIM1, SFN, SFRP5, BUB1, VIM, BRCA1
22	virus-host interaction	GO:019048	10.6	BUB1, RB1, VIM, BNIP3, BNIP3L, KDR
23	cellular response to mechanical stimulus	GO:071260	10.6	BNIP3, CHEK1, BAK1, ITGB1, IL18, IL1B
24	activation of pro-apoptotic gene products	GO:008633	10.6	MYC, BCL2, BAK1, BAX, FASLG, FAS
25	response to cytokine stimulus	GO:034097	10.5	SERPINE1, BCL2, JUN, JUNB, FOSL1, IL4
26	response to drug	GO:042493	10.5	SFRP1, SFRP2, VEGFC, MYC, BCL2, YWHAZ
27	cellular response to hydrogen peroxide	GO:070301	10.4	KLF2, BNIP3, CDK1, IL18, IL6, ANXA1
28	response to ethanol	GO:045471	10.4	BCL2, BAK1, FYN, CDK1, MMP9, MGMT
29	negative regulation of neuron apoptotic process	GO:043524	10.4	BCL2, LGMN, BAX, XRCC2, XRCC4, JUN
30	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.4	VHL, MYC, RARB, PARP1, LEP, AURKB
31	response to estradiol stimulus	GO:032355	10.4	SFRP4, BRCA2, RARA, MMP9, IL1B, ANXA1
32	negative regulation of apoptotic process	GO:043066	10.4	PIM1, SFRP1, SERPINE1, VEGFA, BNIP3L, MYC
33	response to mechanical stimulus	GO:009612	10.4	JUN, JUNB, MMP9, FOSL1, IGFBP2, CAV1
34	Ras protein signal transduction	GO:007265	10.3	RB1, CDKN1A, CDK2, CDKN2A, CDK1, MAPK3
35	anti-apoptosis	GO:006916	10.2	VHL, BNIP3, BIRC5, BCL2, YWHAZ, CDK1
36	response to hypoxia	GO:001666	10.0	VEGFA, BNIP3, USF1, BCL2, LEP, XRCC1
37	positive regulation of cell division	GO:051781	9.9	VEGFA, VEGFC, FGF3, FGF4, IL1A, IL1B
38	MAPK cascade	GO:000165	9.9	MYC, CDK1, FGFR3, IL18, IL1B, MAPK3
39	response to glucocorticoid stimulus	GO:051384	9.9	SFRP4, SERPINE1, IL10, IL1B, IL6, FAS
40	positive regulation of cell proliferation	GO:008284	9.8	SFRP1, SFRP2, VEGFA, VEGFC, MYC, RARA
41	angiogenesis	GO:001525	9.8	SETD2, SERPINE1, VEGFA, VEGFC, KDR, JUN
42	negative regulation of cell proliferation	GO:008285	9.7	KLF13, SFN, SFRP1, SFRP2, SFRP4, SFRP5
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.7	KLF13, KLF2, SFRP2, RB1, RBMX, SERPINE1
44	epidermal growth factor receptor signaling pathway	GO:007173	9.7	CDKN1B, CDK1, MDM2, MAPK3, MAPK1, CASP9
45	aging	GO:007568	9.6	BAK1, JUN, IL1B, FAS, IGFBP2, ALDH3A1
46	positive regulation of transcription, DNA-dependent	GO:045893	9.4	KLF2, SFRP1, RB1, BRCA1, BRCA2, VHL
47	platelet degranulation	GO:002576	9.2	SERPINE1, VEGFA, VEGFC, ITGB3, FN1, IGF1
48	blood coagulation	GO:007596	9.2	SERPINE1, VEGFA, VEGFC, YWHAZ, ATP2B1, FYN
49	positive regulation of protein phosphorylation	GO:001934	8.6	VEGFA, ITGB3, IL1B, ENG, MAPK3, CCND1
50	platelet activation	GO:030168	7.8	SERPINE1, VEGFA, VEGFC, YWHAZ, FYN, ITGB3

Molecular functions related to oral cancer according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	11.1	HDAC2, HMOX1, CAV1, CAT, CCND1, MDM2
2	glutathione transferase activity	GO:004364	11.1	GSTT1, GSTP1, GSTM3, GSTM1, GSTA4, GSTA2
3	transcription factor binding	GO:008134	10.8	NFKBIA, CREBBP, CTNNB1, TNFRSF10A, TP73, HIF1A
4	protein binding	GO:005515	10.4	KRT19, CREBBP, SMARCA4, SNAI1, CTSL1, CTSB
5	protein homodimerization activity	GO:042803	10.2	XPA, JUN, GSTA4, GSTM3, ENG, BAX
6	identical protein binding	GO:042802	9.9	BAK1, BCL2, BIRC5, RAD51, BNIP3L, CASP8
7	growth factor activity	GO:008083	8.3	IL6, IL4, IL1B, IL10, FGF4, FGF3