MCID: ORL011
MIFTS: 47

Oral Cancer malady

Rare diseases, Oral diseases, Cancer diseases categories

Summaries for Oral Cancer

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MedlinePlus:32 Oral cancer can form in any part of the mouth or throat. most oral cancers begin in the tongue and in the floor of the mouth. anyone can get oral cancer, but the risk is higher if you are male, over age 40, use tobacco or alcohol or have a history of head or neck cancer. frequent sun exposure is also a risk for lip cancer. symptoms of oral cancer include white or red patches in your mouth a mouth sore that won't heal bleeding in your mouth loose teeth problems or pain with swallowing a lump in your neck an earache oral cancer treatments may include surgery, radiation therapy or chemotherapy. some patients have a combination of treatments. nih: national cancer institute

MalaCards based summary: Oral Cancer, also known as lip and oral cavity carcinoma, is related to leukoplakia and lung cancer. An important gene associated with Oral Cancer is GSTM3 (glutathione S-transferase mu 3 (brain)), and among its related pathways are Estrogen metabolism and 2 Naphthylamine and 2 Nitronaphtalene metabolism. The compounds trans,trans-muconic acid and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and endothelial, and related mouse phenotypes are tumorigenesis and integument.

NIH Rare Diseases:41 Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth). most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. about 35,000 individuals in the united stated are diagnosed with oral cancer each year. the use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy. last updated: 3/9/2010

Wikipedia:63 Oral cancer or mouth cancer, a type of head and neck cancer, is any cancerous tissue growth located in... more...

Aliases & Classifications for Oral Cancer

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Oral Cancer, Aliases & Descriptions:

Name: Oral Cancer 41 43 32 3
Lip and Oral Cavity Carcinoma 60
 
Malignant Neoplasm of Mouth 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


Related Diseases for Oral Cancer

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Diseases related to Oral Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia31.0TERC, CYP1A1, GSTM1, GSTT1, KRT13
2lung cancer29.6GSTP1, GSTM1, CCND1, CYP2E1
3prostate cancer29.5TERC, CYP2E1, GSTM1, GSTP1, GSTT1, S100A2
4leukemia28.3TERC, CYP1A1, CYP2E1, CCND1, GSTM1, GSTP1
5asbestosis10.4GSTT1, GSTM1
6senile cataract10.4GSTT1, GSTM1
7oral lichen planus10.4
8mismatch repair cancer syndrome10.3GSTT1, GSTM1
9brain cancer10.3CYP1A1, GSTM1, GSTT1
10lichen planus10.3
11oral submucous fibrosis10.3
12cervicitis10.3
13acute myeloid leukemia, adult10.3CYP1A1, GSTM1, GSTT1
14open-angle glaucoma10.3GSTT1, GSTM1
15oral leukoplakia10.3
16aplastic anemia10.3TERC, GSTM1, GSTT1
17oral squamous cell carcinoma10.3
18hypoxia10.3
19endotheliitis10.3
20gastritis10.2TERC, GSTT1
21esophageal cancer10.2GSTM1, CCND1
22gastric adenocarcinoma10.2TERC, GSTM1, GSTT1
23endometriosis10.2CYP1A1, GSTM1, GSTT1
24alcoholic pancreatitis10.2ADH1C, CYP2E1
25myelodysplastic syndrome10.2GSTT1, GSTM1, TERC
26erythroplakia10.2
27paraneoplastic syndromes10.2
28alcoholic liver cirrhosis10.2GSTM1, ADH1C, CYP2E1
29cervical cancer, somatic10.2TERC, SERPINB3, GSTM1, GSTT1
30pancreatitis, hereditary10.1CYP2E1, ADH1C, GSTT1
31basal cell carcinoma10.1CYP1A1, GSTM3, GSTM1, GSTT1, S100A2
32papilloma10.1
33thyroid cancer10.1CCND1, GSTM1, GSTT1
34infertility10.1GSTT1, CYP1A1, TERC
35leukemia, acute lymphoblastic10.1GSTT1, GSTP1, GSTM1, CYP1A1
36transitional cell carcinoma10.1GSTT1, GSTP1, GSTM1, TERC
37acute leukemia10.0GSTT1, GSTP1, GSTM1, TERC
38xeroderma pigmentosum, variant type10.0CYP1A1, GSTT1, GADD45A
39mucoepidermoid carcinoma10.0
40tongue cancer10.0
41mutagen sensitivity10.0
42liver cirrhosis10.0ADH1C, CYP2E1, TERC
43psoriasis10.0CTSL, KRT13, S100A2, SERPINB3
44nasopharyngeal carcinoma10.0CYP1A1, CYP2E1, GSTM1, GSTT1, KRT13
45pancreatitis10.0CYP2E1, ADH1C, GSTP1
46lung benign neoplasm10.0CTSL, GSTP1, CYP1A1, TERC
47alcohol abuse10.0CYP2E1, ADH1C
48nicotine dependence, protection against10.0CYP1A1, CYP2E1, GSTM1, GSTP1, GSTT1
49acute lymphoblastic leukemia, childhood10.0CYP1A1, CYP2E1, GSTM1, GSTP1, GSTT1
50pulmonary disease, chronic obstructive9.9GSTT1, GSTP1, GSTM1, CYP2E1, CYP1A1

Graphical network of the top 20 diseases related to Oral Cancer:



Diseases related to oral cancer

Symptoms for Oral Cancer

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Drugs & Therapeutics for Oral Cancer

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Drug clinical trials:

Search ClinicalTrials for Oral Cancer

Search NIH Clinical Center for Oral Cancer

Genetic Tests for Oral Cancer

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Anatomical Context for Oral Cancer

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MalaCards organs/tissues related to Oral Cancer:

31
Tongue, Lymph node, Endothelial, Lung, Bone, Smooth muscle, Colon, Salivary gland, Skin, Placenta, Prostate, Testes, T cells, Neutrophil

Animal Models for Oral Cancer or affiliated genes

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MGI Mouse Phenotypes related to Oral Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TERC, CYP2E1, CCND1, GSTP1, GADD45A
2MP:00107717.8ANO1, CCND1, GSTP1, GADD45A, CTSL, TERC
3MP:00053767.1CTSL, TERC, CYP1A1, CYP2E1, ADH1C, ANO1
4MP:00053787.0TERC, CYP1A1, ADH1C, ANO1, CCND1, GSTP1
5MP:00107686.9TERC, CYP1A1, CYP2E1, ADH1C, ANO1, CCND1

Publications for Oral Cancer

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Articles related to Oral Cancer:

(show top 50)    (show all 992)
idTitleAuthorsYear
1
Support needs and quality of life in oral cancer: a systematic review. (24034791)
2014
2
Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India. (23444898)
2014
3
Tobacco (kretek) smoking, betel quid chewing and risk of oral cancer in a selected jakarta population. (25374188)
2014
4
Mitochondrial DNA mutations may not be frequent in patients with oral cancer. (24047158)
2013
5
Oral cancer: from bench to bedside, the continuous effort towards better diagnostic, treatment and prognostic tools. (24212982)
2013
6
Assessing dental students' knowledge of oral cancer in the United Arab Emirates. (23550520)
2013
7
Inflammation in the context of oral cancer. (23910564)
2013
8
The dentist's role within the multi-disciplinary team maintaining quality of life for oral cancer patients in light of recent advances in radiotherapy. (23858630)
2013
9
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
10
Multiple drug resistant, tumorigenic stem-like cells in oral cancer. (23791883)
2013
11
Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. (23378643)
2013
12
Oral cancer screenings. (24357559)
2013
13
Tumour classification for early oral cancer - is the current TNM classification adequate? (24375610)
2013
14
Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy. (23695424)
2013
15
Alterations in serum lipid profile patterns in oral cancer. (24082735)
2013
16
Epidemiology of oral cancer in Asia in the past decade--an update (2000-2012). (24289546)
2013
17
Evaluation of p53 protein as a prognostic factor for oral cancer surgery. (23791033)
2013
18
Oral cancer screening. (22529545)
2012
19
Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer. (22341307)
2012
20
Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols. (22817766)
2012
21
Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer. (21472888)
2012
22
Patients' perceptions of oral cancer screening in dental practice: a cross-sectional study. (23249393)
2012
23
Promoting oral cancer awareness and early detection using a mass media approach. (22799308)
2012
24
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 17. Osteonecrosis. (22852516)
2012
25
Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. (22126492)
2011
26
Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. (21840245)
2011
27
Oral cancer-associated paraneoplastic syndromes. (21180290)
2010
28
Alteration in the expression of cdk4 and cdk6 proteins in oral cancer and premalignant lesions. (20618617)
2010
29
PGE2 production in oral cancer cell lines is COX-2-dependent. (19278989)
2009
30
CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. (20695076)
2009
31
Association of polymorphisms in Tumor Necrosis Factor Alpha and Beta genes with increased risk for oral cancer. (19528505)
2009
32
A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients. (17933579)
2008
33
Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma. (19048118)
2008
34
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer. (18243718)
2008
35
Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan. (18487076)
2008
36
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. (17325662)
2007
37
Over-expression of 14-3-3zeta is an early event in oral cancer. (17764575)
2007
38
The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. (16886618)
2006
39
Genetic and epigenetic alterations of BRG1 promote oral cancer development. (15586241)
2005
40
Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. (15863273)
2005
41
Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. (14719121)
2004
42
Chemoprevention of oral cancer]. (12822012)
2003
43
No mutations of the Bub1 gene in human gastric and oral cancer cell lines. (12375025)
2002
44
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. (11960911)
2002
45
Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report. (12162763)
2002
46
Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. (11140899)
2001
47
Localization of a novel tumor suppressor gene loci on chromosome 9p21-22 in oral cancer. (10226521)
1999
48
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. (9367063)
1997
49
Lipoxygenase products in human saliva: patients with oral cancer compared to controls. (7744301)
1995
50
Cytokeratin expression in oral cancer and its relationship to tumor differentiation. (7680377)
1993

Variations for Oral Cancer

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Cosmic variations for Oral Cancer:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
128675CDKN2Aupper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma1

Expression for genes affiliated with Oral Cancer

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Search GEO for disease gene expression data for Oral Cancer.

Pathways for genes affiliated with Oral Cancer

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Pathways related to Oral Cancer according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1GSTM1, CYP1A1
210.0CYP2E1, CYP1A1
310.0GSTP1, GSTT1
4
Show member pathways
9.9GSTP1, ADH1C
59.8GSTM1, GSTP1, GSTT1
6
Show member pathways
9.8ADH1C, CYP2E1, CYP1A1
79.7GSTP1, CYP2E1, CYP1A1
8
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.6GSTT1, GSTP1, GSTM1, GSTM3
99.4CYP1A1, CYP2E1, GSTM1, GSTP1, GSTT1
10
Show member pathways
8.9CYP1A1, CYP2E1, ADH1C, GSTM3, GSTM1, GSTP1
11
Show member pathways
8.9GSTT1, GSTP1, GSTM1, GSTM3, ADH1C, CYP2E1
12
Show member pathways
8.7CYP1A1, CYP2E1, ADH1C, TCN1, GSTM3, GSTM1

Compounds for genes affiliated with Oral Cancer

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Compounds related to Oral Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1trans,trans-muconic acid4310.2CYP2E1, GSTT1, GSTM1
2methylchloride4310.2GSTP1, GSTM1, GSTT1
3butadiene monoxide4310.2CYP2E1, GSTM1, GSTT1
4cumene hydroperoxide4310.1GSTM1, GSTT1, GSTP1
5vinylchloride4310.1GSTM1, CYP2E1, GSTT1
6toluene4310.1GSTT1, GSTM1, CYP2E1
7debrisoquine43 4911.1CYP2E1, CYP1A1, GSTM1
8Estrone-2,3-quinone2410.1GSTP1, GSTT1, GSTM1, GSTM3
94-Hydroxyestrone-2-S-glutathione2410.1GSTM3, GSTM1, GSTP1, GSTT1
102-Hydroxyestrone-4-S-glutathione2410.1GSTM3, GSTP1, GSTT1, GSTM1
11S-(PGJ2)-glutathione2410.0GSTM3, GSTM1, GSTP1, GSTT1
12Estrone-3,4-quinone2410.0GSTM3, GSTM1, GSTP1, GSTT1
132-Hydroxyestrone-1-S-glutathione2410.0GSTM3, GSTM1, GSTP1, GSTT1
141-chloro-24-dinitrobenzene4310.0GSTP1, GSTT1, GSTM1
15noradrenochrome43 2411.0GSTM3, GSTM1, GSTP1, GSTT1
16hydrochloric acid43 2411.0GSTM3, GSTM1, GSTP1, GSTT1
17bpde4310.0GSTM1, CYP1A1, GSTP1, GSTT1
18adrenochrome43 2411.0GSTP1, GSTM3, GSTT1, GSTM1
19mspi4310.0CYP1A1, GSTM1, GSTT1, CYP2E1
20s-phenylmercapturic acid4310.0GSTT1, CYP2E1, GSTP1, GSTM1
211,3-butadiene4310.0GSTP1, CYP2E1, GSTM1, GSTT1
22styrene4310.0CYP2E1, GSTM1, GSTP1, GSTT1
23trichloroethylene4310.0GSTM1, GSTP1, GSTT1, CYP2E1
24hydrocarbons4310.0GSTT1, CYP1A1, GSTM1, GSTP1
25rsai4310.0CYP2E1, ADH1C, GSTT1, GSTM1
26Glutathione24 1211.0GSTM3, GSTM1, GSTP1, GSTT1
27dichloromethane439.9GSTP1, GSTT1, CYP2E1
28benzo(a)pyrene439.9CYP1A1, GSTT1, GSTP1, GSTM1
29sulforaphane439.9CYP1A1, CCND1, GSTM1, GSTP1
30isoniazid43 49 1211.8GSTT1, GSTM1, CYP2E1
311-hydroxypyrene439.8CYP1A1, GSTT1, GSTM1, GSTP1, CYP2E1
32oxaliplatin43 49 1211.8CYP1A1, GSTM1, GSTP1, CYP2E1, GSTT1
33thalidomide43 49 59 1212.7GSTT1, CCND1, CYP2E1, CYP1A1
34phenethyl isothiocyanate2 4310.7CCND1, CYP1A1, GSTP1
35gsts439.6GSTP1, CYP1A1, GSTM3, GSTM1, CYP2E1, GSTT1
36epoxide439.6GSTT1, GSTP1, GSTM1, GSTM3, CYP2E1, CYP1A1
37formaldehyde43 2410.6CYP1A1, ADH1C, GSTT1, CCND1, CYP2E1
38ascorbic acid43 2410.5GSTM1, CYP2E1, GSTP1, GSTT1, CYP1A1
39acetone439.5GSTM1, CYP2E1, GSTT1, GSTP1, CCND1, CYP1A1
40cyclophosphamide43 49 1211.3GSTP1, GSTM1, GSTM3, ADH1C, CYP1A1, GSTT1
41chlorambucil43 1210.3GSTP1, GSTM1, GADD45A
42Water249.2GSTM1, CYP1A1, GSTT1, GSTP1, GSTM3, ADH1C
43curcumin438.9GADD45A, TERC, CYP1A1, CCND1, GSTP1
44doxorubicin43 49 1210.8TERC, GSTP1, GADD45A, GSTT1, GSTM1, CCND1
45thymidylate438.6GSTP1, GSTM1, CCND1, GADD45A
46etoposide43 49 59 1211.5S100A2, TERC, CYP2E1, GSTP1, GSTT1, GADD45A
47estrogen438.5CYP1A1, CCND1, GSTM1, GSTT1, GSTP1, TERC
48h2o2438.1GSTP1, CYP1A1, CYP2E1, S100A2, GADD45A, GSTM1
49retinoic acid43 248.9CTSL, GADD45A, KRT13, GSTP1, CCND1, CYP2E1
50cisplatin43 49 59 1210.4GSTM1, TERC, GADD45A, CYP2E1, CYP1A1, CTSL

GO Terms for genes affiliated with Oral Cancer

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Biological processes related to Oral Cancer according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular detoxification of nitrogen compoundGO:007045810.3GSTM3, GSTM1
2nitrobenzene metabolic processGO:001891610.2GSTM3, GSTM1
3xenobiotic catabolic processGO:004217810.2GSTM1, GSTM3
4drug metabolic processGO:001714410.0CYP2E1, CYP1A1
5glutathione derivative biosynthetic processGO:019016879.9GSTM3, GSTM1, GSTP1, GSTT1
6glutathione metabolic processGO:00067499.8GSTM3, GSTM1, GSTP1, GSTT1
7response to organonitrogen compoundGO:00102439.8CCND1, CYP2E1
8oxidation-reduction processGO:00551149.5GSTT1, CYP2E1, CYP1A1
9response to drugGO:00424939.5CYP1A1, CYP2E1, CCND1, GSTT1
10xenobiotic metabolic processGO:00068059.1GSTT1, GSTP1, GSTM1, GSTM3, ADH1C, CYP2E1
11small molecule metabolic processGO:00442818.9CYP1A1, CYP2E1, ADH1C, TCN1, GSTM3, GSTM1

Molecular functions related to Oral Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:004329510.1GSTM1, GSTM3
2glutathione transferase activityGO:00043649.5GSTT1, GSTP1, GSTM1, GSTM3
3enzyme bindingGO:00198999.1CYP1A1, CYP2E1, CCND1, GSTM3, GSTM1

Products for genes affiliated with Oral Cancer

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  • Antibodies
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Sources for Oral Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet