MCID: ORL011
MIFTS: 38

Oral Cancer malady

Oral diseases, Cancer diseases categories

Summaries for Oral Cancer

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Oral cancer can form in any part of the mouth or throat. most oral cancers begin in the tongue and in the floor of the mouth. anyone can get oral cancer, but the risk is higher if you are male, over age 40, use tobacco or alcohol or have a history of head or neck cancer. frequent sun exposure is also a risk for lip cancer. symptoms of oral cancer include white or red patches in your mouth a mouth sore that won't heal bleeding in your mouth loose teeth problems or pain with swallowing a lump in your neck an earache oral cancer treatments may include surgery, radiation therapy or chemotherapy. some patients have a combination of treatments. nih: national cancer institute

MalaCards: Oral Cancer, also known as lip and oral cavity carcinoma, is related to squamous cell carcinoma and cervical cancer. An important gene associated with Oral Cancer is GSTM3 (glutathione S-transferase mu 3 (brain)), and among its related pathways are Drug metabolism - cytochrome P450 and Biological oxidations. The compounds cisplatin and acetone have been mentioned in the context of this disorder. Affiliated tissues include tongue and salivary gland.

NIH Rare Diseases:42 Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth). most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. about 35,000 individuals in the united stated are diagnosed with oral cancer each year. the use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy. last updated: 3/9/2010

Wikipedia:63 Oral cancer or mouth cancer, a subtype of head and neck cancer, is any cancerous tissue growth located... more...

Aliases & Classifications for Oral Cancer

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Sources:
42NIH Rare Diseases, 44Novoseek, 33MedlinePlus, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cancer 42 44 33
lip and oral cavity carcinoma 60


Related Diseases for Oral Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Oral Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.5GSTP1, CYP2E1, CCND1, SERPINB3
2cervical cancer30.4SERPINB3, GSTM1, TERC, SKP2, GSTT1
3lung cancer30.3GSTP1, GSTM1, TERC, CYP2E1, CYP1A1
4prostate cancer29.8CCND1, S100A2, CYP1A1, CYP2E1, SKP2, TERC
5leukemia29.8CYP2E1, CCND1, CYP1A1, TERC, GSTM1, GSTT1
6colon cancer29.8GSTP1, CCND1, CYP1A1, TERC, GSTM1, GSTT1
7acute leukemia29.8GSTP1, GSTT1, GSTM1, TERC
8lymph node cancer10.4
9tongue cancer10.3
10oral submucous fibrosis10.3
11lichen planus10.3
12cervicitis10.3
13vascular cancer10.2
14oral cavity cancer10.1
15papilloma10.1
16adenocarcinoma10.0TERC, KRT13, GSTP1, GSTT1, GSTM1, ADH1C
17hepatocellular carcinoma10.0TERC, CYP1A1, SERPINB3, TCN1, KRT13, CCND1
18adenoma10.0ADH1C, GSTT1, GSTM1, TERC, KRT13, SKP2
19lung adenocarcinoma10.0SKP2, GSTM1, CYP2E1, GSTT1, GSTP1, S100A2
20mucoepidermoid carcinoma10.0
21cell type cancer10.0
22intellectual disability10.0
23laryngeal squamous cell carcinoma10.0CCND1, CYP1A1, CYP2E1, SKP2, GSTM3, GSTM1
24squamous cell carcinoma of the head and neck10.0CCND1, GSTP1, GSTT1, GSTM1, ADH1C, KRT13
25non-hodgkin lymphoma10.0GSTM1, CCND1, CYP1A1, CYP2E1, SKP2, GSTT1
26breast cancer10.0SKP2, GSTP1, CYP1A1, TERC, CCND1, GSTT1
27leukoplakia10.0TERC, CYP1A1, KRT13, GSTM1, GSTT1
28malignant glioma10.0GSTM3, CYP1A1, GSTP1, GSTT1, SLC7A5, TERC
29acute lymphoblastic leukemia, childhood10.0CYP1A1, GSTM1, CYP2E1, GSTT1, GSTP1
30basal cell carcinoma10.0GSTM1, GSTT1, S100A2, CYP1A1, GSTM3
31nasopharynx carcinoma10.0KRT13, CYP2E1, GSTM1, CYP1A1, GSTT1
32asthma10.0GSTM1, SERPINB3, GSTT1, GSTP1, CYP2E1
33melanoma10.0CYP1A1, S100A2, CCND1, SKP2, TERC, GSTT1
34pulmonary disease, chronic obstructive10.0GSTT1, GSTP1, CYP1A1, GSTM1, CYP2E1
35non-small cell lung carcinoma10.0CCND1, CYP2E1, SKP2, GSTM1, GSTP1
36lung small cell carcinoma10.0CYP1A1, GSTP1, TERC, GSTM1, GSTT1
37kidney cancer10.0GSTP1, CYP2E1, GSTT1, CYP1A1, KRT13
38ovarian cancer10.0CYP1A1, SKP2, TERC, CCND1, GSTP1
39barrett's esophagus10.0CCND1, CYP1A1, TERC, GSTP1
40bladder carcinoma in situ10.0SERPINB3, GSTP1, GSTM1, CCND1
41thyroid cancer10.0CCND1, SKP2, GSTM1, GSTT1
42transitional cell carcinoma10.0GSTM1, GSTT1, TERC, GSTP1
43pancreatitis10.0GSTP1, ADH1C, CYP2E1
44brain cancer10.0GSTM1, CYP1A1, GSTT1
45astrocytoma10.0TERC, GSTT1, GSTM3
46pancreatic cancer10.0S100A2, CCND1, TERC
47liver cirrhosis10.0ADH1C, SERPINB3, CYP1A1, CYP2E1
48endometriosis10.0GSTM1, CYP1A1, GSTT1
49bladder carcinoma10.0GSTP1, SLC7A5, TERC
50deficiency anemia10.0GSTM1, TERC, TCN1

Graphical network of the top 20 diseases related to Oral Cancer:



Diseases related to oral cancer

Clinical Features for Oral Cancer

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Drugs & Therapeutics for Oral Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oral Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cancer

Search NIH Clinical Center for Oral Cancer

Search CenterWatch for Oral Cancer

Genetic Tests for Oral Cancer

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Anatomical Context for Oral Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Oral Cancer:

32
Tongue, Salivary gland

Animal Models for Oral Cancer or affiliated genes

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Publications for Oral Cancer

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Genetic Variations for Oral Cancer

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Expression for genes affiliated with Oral Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cancer

Search GEO for disease gene expression data for Oral Cancer.

Pathways for genes affiliated with Oral Cancer

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Oral Cancer

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Oral Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cisplatin44 49 59 1114.7GSTM1, GSTM3, CCND1, CYP1A1, TERC, GSTT1
2acetone4411.6GSTT1, CYP1A1, CYP2E1, GSTM1, CCND1, GSTP1
3gsts4411.6GSTM3, GSTM1, GSTT1, CYP2E1, CYP1A1, GSTP1
4epoxide4411.6CYP1A1, GSTM1, GSTT1, GSTP1, CYP2E1, GSTM3
5cyclophosphamide44 49 1113.6GSTP1, GSTT1, GSTM3, CYP2E1, CYP1A1, GSTM1
61-hydroxypyrene4411.5GSTT1, GSTM1, CYP2E1, CYP1A1, GSTP1
7oxaliplatin44 49 1113.5GSTM1, CYP2E1, GSTP1, GSTT1, CYP1A1
8retinoic acid44 2412.5CYP2E1, KRT13, TERC, CYP1A1, SKP2, CCND1
9formaldehyde44 2412.4GSTT1, ADH1C, CYP2E1, CYP1A1, CCND1
10s-phenylmercapturic acid4411.4GSTP1, GSTM1, CYP2E1, GSTT1
111,3-butadiene4411.4GSTT1, GSTP1, GSTM1, CYP2E1
12styrene4411.4CYP2E1, GSTM1, GSTT1, GSTP1
13trichloroethylene4411.4GSTM1, GSTT1, CYP2E1, GSTP1
14bpde4411.4GSTP1, CYP1A1, GSTM1, GSTT1
15noradrenochrome44 2412.4GSTP1, GSTT1, GSTM1, GSTM3
16hydrochloric acid44 2412.4GSTM3, GSTT1, GSTP1, GSTM1
17ascorbic acid44 2412.3GSTT1, GSTP1, GSTM1, CYP2E1, CYP1A1
18adrenochrome44 2412.3GSTM1, GSTT1, GSTM3, GSTP1
19rsai4411.3CYP2E1, ADH1C, GSTT1, GSTM1
20hydrocarbons4411.3GSTM1, CYP1A1, GSTP1, GSTT1
21mspi4411.3GSTM1, GSTT1, CYP1A1, CYP2E1
22sulforaphane4411.3GSTM1, CYP1A1, GSTP1, CCND1
23Glutathione11 2412.3GSTP1, GSTT1, GSTM1, GSTM3
24benzo(a)pyrene4411.3GSTT1, GSTP1, GSTM1, CYP1A1
25methylchloride4411.2GSTM1, GSTT1, GSTP1
26trans,trans-muconic acid4411.2CYP2E1, GSTM1, GSTT1
27butadiene monoxide4411.2GSTT1, GSTM1, CYP2E1
28cumene hydroperoxide4411.2GSTM1, GSTT1, GSTP1
29vinylchloride4411.2GSTM1, CYP2E1, GSTT1
30p0024411.2SKP2, ADH1C, GSTM1, GSTT1
31toluene4411.2GSTT1, GSTM1, CYP2E1
32sulfate44 2412.2GSTM1, GSTM3, GSTP1, GSTT1
33debrisoquine4411.2GSTM1, CYP2E1, CYP1A1
341-chloro-24-dinitrobenzene4411.2GSTT1, GSTP1, GSTM1
35dichloromethane4411.2CYP2E1, GSTP1, GSTT1
36troglitazone44 28 59 1114.2CYP1A1, CCND1, SKP2, KRT13
37phenethyl isothiocyanate44 212.1CYP1A1, CCND1, GSTP1
38etoposide44 49 59 1114.1S100A2, CYP2E1, GSTP1
39isoniazid49 44 1113.1CYP2E1, GSTM1, GSTT1
40benzene4411.1GSTT1, GSTM1, CYP2E1
41doxorubicin44 49 1113.0CCND1, TERC, GSTP1, GSTT1, GSTM1
42(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1111.0GSTP1, GSTM1
43dcnb4411.0GSTP1, GSTM1
44n-nitrosomethylbenzylamine4410.9CCND1, CYP2E1
45drugs for treatment of tuberculosis4910.9GSTT1, GSTM1
46n-(2-hydroxyethyl)valine4410.8GSTT1, GSTM1
47ifosfamide44 1111.7GSTM1, GSTP1, GSTT1
482,4,6-trinitrotoluene4410.7GSTM1, GSTP1
49egcg4410.7CYP2E1
50glycidamide4410.4CYP2E1, GSTP1

GO Terms for genes affiliated with Oral Cancer

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Sources:
16Gene Ontology
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Biological processes related to Oral Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.5CYP1A1, CYP2E1, TCN1, ADH1C, GSTM3, GSTM1
2xenobiotic metabolic processGO:00680511.5GSTP1, GSTT1, GSTM1, GSTM3, ADH1C, CYP2E1
3glutathione derivative biosynthetic processGO:190168711.1GSTM3, GSTM1, GSTT1, GSTP1
4glutathione metabolic processGO:00674911.1GSTM3, GSTM1, GSTT1, GSTP1
5nitrobenzene metabolic processGO:01891610.8GSTM1, GSTM3
6cellular detoxification of nitrogen compoundGO:07045810.7GSTM1, GSTM3
7response to organonitrogen compoundGO:01024310.7CYP2E1, CCND1
8response to drugGO:04249310.6GSTT1, CYP2E1, CYP1A1, CCND1
9xenobiotic catabolic processGO:04217810.6GSTM3, GSTM1

Molecular functions related to Oral Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.8GSTP1, GSTT1, GSTM1, GSTM3
2enzyme bindingGO:01989910.7CCND1, CYP1A1, CYP2E1, GSTM3, GSTM1
3glutathione bindingGO:04329510.7GSTM1, GSTM3

Products for genes affiliated with Oral Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet