MCID: ORL011
MIFTS: 50

Oral Cancer malady

Oral, Cancer categories

Summaries for Oral Cancer

Sources:
43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Oral cancer can form in any part of the mouth or throat. most oral cancers begin in the tongue and in the floor of the mouth. anyone can get oral cancer, but the risk is higher if you are male, over age 40, use tobacco or alcohol or have a history of head or neck cancer. frequent sun exposure is also a risk for lip cancer. symptoms of oral cancer include white or red patches in your mouth a mouth sore that won't heal bleeding in your mouth loose teeth problems or pain with swallowing a lump in your neck an earache oral cancer treatments may include surgery, radiation therapy or chemotherapy. some patients have a combination of treatments. nih: national cancer institute

MalaCards: Oral Cancer, also known as lip and oral cavity carcinoma, is related to leukoplakia and squamous cell carcinoma. An important gene associated with Oral Cancer is GSTM3 (glutathione S-transferase mu 3 (brain)), and among its related pathways are Drug metabolism - cytochrome P450 and Biological oxidations. The compounds cisplatin and acetone have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and heart.

NIH Rare Diseases:43 Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth). most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. about 35,000 individuals in the united stated are diagnosed with oral cancer each year. the use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy. last updated: 3/9/2010

Wikipedia:64 Oral cancer or mouth cancer, a subtype of head and neck cancer, is any cancerous tissue growth located... more...

Aliases & Classifications for Oral Cancer

Sources:
43NIH Rare Diseases, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Oral


Aliases & Descriptions:

oral cancer 43 45 34
lip and oral cavity carcinoma 61


Related Diseases for Oral Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia30.9TERC, CYP1A1, KRT13, GSTM1, GSTT1
2squamous cell carcinoma30.6GSTP1, CYP2E1, CCND1, SERPINB3
3acute leukemia29.8GSTP1, GSTT1, GSTM1, TERC
4oral leukoplakia10.6
5tongue cancer10.4
6oral squamous cell carcinoma10.4
7oral submucous fibrosis10.4
8oral lichen planus10.3
9lichen planus10.3
10hypoxia10.3
11vascular cancer10.2
12erythroplakia10.2
13paraneoplastic syndromes10.2
14mucoepidermoid carcinoma10.0
15mutagen sensitivity10.0
16radiation induced cancer10.0
17adenocarcinoma10.0TERC, KRT13, GSTP1, GSTT1, GSTM1, ADH1C
18hepatocellular carcinoma10.0TERC, CYP1A1, SERPINB3, TCN1, KRT13, CCND1
19adenoma10.0ADH1C, GSTT1, GSTM1, TERC, KRT13, SKP2
20prostate cancer10.0CCND1, S100A2, CYP1A1, CYP2E1, SKP2, TERC
21lung adenocarcinoma10.0SKP2, GSTM1, CYP2E1, GSTT1, GSTP1, S100A2
22laryngeal squamous cell carcinoma10.0CCND1, CYP1A1, CYP2E1, SKP2, GSTM3, GSTM1
23squamous cell carcinoma of the head and neck10.0CCND1, GSTP1, GSTT1, GSTM1, ADH1C, KRT13
24leukemia10.0CYP2E1, CCND1, CYP1A1, TERC, GSTM1, GSTT1
25non-hodgkin lymphoma10.0GSTM1, CCND1, CYP1A1, CYP2E1, SKP2, GSTT1
26breast cancer10.0SKP2, GSTP1, CYP1A1, TERC, CCND1, GSTT1
27malignant glioma10.0GSTM3, CYP1A1, GSTP1, GSTT1, SLC7A5, TERC
28colon cancer10.0GSTP1, CCND1, CYP1A1, TERC, GSTM1, GSTT1
29acute lymphoblastic leukemia, childhood10.0CYP1A1, GSTM1, CYP2E1, GSTT1, GSTP1
30basal cell carcinoma10.0GSTM1, GSTT1, S100A2, CYP1A1, GSTM3
31nasopharynx carcinoma10.0KRT13, CYP2E1, GSTM1, CYP1A1, GSTT1
32asthma10.0GSTM1, SERPINB3, GSTT1, GSTP1, CYP2E1
33melanoma10.0CYP1A1, S100A2, CCND1, SKP2, TERC, GSTT1
34pulmonary disease, chronic obstructive10.0GSTT1, GSTP1, CYP1A1, GSTM1, CYP2E1
35non-small cell lung carcinoma10.0CCND1, CYP2E1, SKP2, GSTM1, GSTP1
36cervical cancer10.0SERPINB3, GSTM1, TERC, SKP2, GSTT1
37lung small cell carcinoma10.0CYP1A1, GSTP1, TERC, GSTM1, GSTT1
38lung cancer10.0GSTP1, GSTM1, TERC, CYP2E1, CYP1A1
39kidney cancer10.0GSTP1, CYP2E1, GSTT1, CYP1A1, KRT13
40ovarian cancer10.0CYP1A1, SKP2, TERC, CCND1, GSTP1
41barrett's esophagus10.0CCND1, CYP1A1, TERC, GSTP1
42bladder carcinoma in situ10.0SERPINB3, GSTP1, GSTM1, CCND1
43thyroid cancer10.0CCND1, SKP2, GSTM1, GSTT1
44transitional cell carcinoma10.0GSTM1, GSTT1, TERC, GSTP1
45pancreatitis10.0GSTP1, ADH1C, CYP2E1
46brain cancer10.0GSTM1, CYP1A1, GSTT1
47astrocytoma10.0TERC, GSTT1, GSTM3
48pancreatic cancer10.0S100A2, CCND1, TERC
49liver cirrhosis10.0ADH1C, SERPINB3, CYP1A1, CYP2E1
50endometriosis10.0GSTM1, CYP1A1, GSTT1

Graphical network of the top 20 diseases related to Oral Cancer:



Diseases related to oral cancer

Clinical Features for Oral Cancer

Drugs & Therapeutics for Oral Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cancer

Search NIH Clinical Center for Oral Cancer

Search CenterWatch for Oral Cancer

Genetic Tests for Oral Cancer

Anatomical Context for Oral Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Oral Cancer:

33
Whole blood, Lymph node, Heart, Smooth muscle, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Breast, Skin, Placenta, Prostate, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Tongue

Animal Models for Oral Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Oral Cancer

Sources:
51PubMed
See all sources

Articles related to Oral Cancer:

(show top 50)    (show all 1632)
idTitleAuthorsYear
1
Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease. (24399081)
2014
2
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. (23733351)
2013
3
Aetiology of Oral Cancer in the Sudan. (24422031)
2013
4
Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer. (23748454)
2013
5
Decreased functional response to Toll like receptor ligands in patients with oral cancer. (23628388)
2013
6
Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer. (23876628)
2013
7
Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway. (24375483)
2013
8
Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. (22775506)
2013
9
Saliva collection methods for DNA biomarker analysis in oral cancer patients. (23068125)
2013
10
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-I_B and matrix metalloproteinase-2/-9 signaling pathways. (23645742)
2013
11
Promoting oral cancer awareness and early detection using a mass media approach. (22799308)
2012
12
Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation. (22820424)
2012
13
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 18. Dental management. (22928458)
2012
14
Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer. (22752215)
2012
15
Prognostic impact of the level of neck metastasis in oral cancer patients. (23306562)
2012
16
Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. (22554995)
2012
17
Visualization of the sentinel node in early-stage oral cancer: limited value of late static lymphoscintigraphy. (22828452)
2012
18
Applications of nanomedicine in oral cancer. (22692272)
2012
19
AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells. (22922805)
2012
20
Survivin SNP-carcinogen interactions in oral cancer. (22318371)
2012
21
Identification of a high-risk subgroup of patients with resected pT3 oral cavity cancer in need of postoperative adjuvant therapy. (21360248)
2011
22
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer. (21868508)
2011
23
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
24
HuR knockdown changes the oncogenic potential of oral cancer cells. (20332213)
2010
25
Compliance with quality assurance measures in patients treated for early oral tongue cancer. (20564059)
2010
26
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. (19259098)
2009
27
ORAOV1-A correlates with poor differentiation in oral cancer. (19493886)
2009
28
Distress and care needs in newly diagnosed oral cavity cancer patients receiving surgery. (19250858)
2009
29
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer. (18251940)
2008
30
Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan. (18630527)
2008
31
Genetic variation in interleukin-10 gene and risk of oral cancer. (17980158)
2008
32
Oral cancer cell lines can use multiple ligands, including Fas-L, TRAIL and TNF-alpha, to induce apoptosis in Jurkat T cells: possible mechanisms for immune escape by head and neck cancers. (17996489)
2008
33
HnRNP E2 is downregulated in human oral cancer cells and the overexpression of hnRNP E2 induces apoptosis. (17219427)
2007
34
The platelet glycoprotein Ibalpha VNTR polymorphism is associated with risk for oral cancer. (18225582)
2007
35
Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy. (16425285)
2006
36
Cyclin A activity predicts clinical outcome in oral precancer and cancer. (16962288)
2006
37
DNA identification of the pathogen of candidal aspiration pneumonia induced in the course of oral cancer therapy. (15824430)
2005
38
Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer. (16007067)
2005
39
Signal transducers and activators of transcription: insights into the molecular basis of oral cancer. (15470267)
2004
40
Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet. (12912968)
2003
41
p53 expression in oral cancer: observations of a South Indian study. (14582705)
2003
42
Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity. (11745290)
2001
43
Expression of heparanase in oral cancer cell lines and oral cancer tissues. (11167146)
2001
44
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients. (11139311)
2001
45
Comparison of GSTM polymorphisms and risk for oral cancer between African-Americans and Caucasians. (10762000)
2000
46
Recent development of oral anti-cancer drugs for breast cancer]. (10065092)
1999
47
Selenium and oral cancer. Review of the literature]. (8984328)
1996
48
Mutagen sensitivity as a predisposing factor in familial oral cancer. (8797865)
1996
49
Treatment of stage I and II oral tongue cancer. (8360052)
1993
50
Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer. (1544110)
1992

Genetic Variations for Oral Cancer

Expression for genes affiliated with Oral Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Cancer

Search GEO for disease gene expression data for Oral Cancer.

Pathways for genes affiliated with Oral Cancer

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Compounds for genes affiliated with Oral Cancer

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Oral Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cisplatin45 50 60 1114.7GSTM1, GSTM3, CCND1, CYP1A1, TERC, GSTT1
2acetone4511.6GSTT1, CYP1A1, CYP2E1, GSTM1, CCND1, GSTP1
3gsts4511.6GSTM3, GSTM1, GSTT1, CYP2E1, CYP1A1, GSTP1
4epoxide4511.6CYP1A1, GSTM1, GSTT1, GSTP1, CYP2E1, GSTM3
5cyclophosphamide45 50 1113.6GSTP1, GSTT1, GSTM3, CYP2E1, CYP1A1, GSTM1
61-hydroxypyrene4511.5GSTT1, GSTM1, CYP2E1, CYP1A1, GSTP1
7oxaliplatin45 50 1113.5GSTM1, CYP2E1, GSTP1, GSTT1, CYP1A1
8retinoic acid45 2412.5CYP2E1, KRT13, TERC, CYP1A1, SKP2, CCND1
9formaldehyde45 2412.4GSTT1, ADH1C, CYP2E1, CYP1A1, CCND1
10s-phenylmercapturic acid4511.4GSTP1, GSTM1, CYP2E1, GSTT1
111,3-butadiene4511.4GSTT1, GSTP1, GSTM1, CYP2E1
12styrene4511.4CYP2E1, GSTM1, GSTT1, GSTP1
13trichloroethylene4511.4GSTM1, GSTT1, CYP2E1, GSTP1
14bpde4511.4GSTP1, CYP1A1, GSTM1, GSTT1
15noradrenochrome45 2412.4GSTP1, GSTT1, GSTM1, GSTM3
16hydrochloric acid45 2412.4GSTM3, GSTT1, GSTP1, GSTM1
17ascorbic acid45 2412.3GSTT1, GSTP1, GSTM1, CYP2E1, CYP1A1
18adrenochrome45 2412.3GSTM1, GSTT1, GSTM3, GSTP1
19rsai4511.3CYP2E1, ADH1C, GSTT1, GSTM1
20hydrocarbons4511.3GSTM1, CYP1A1, GSTP1, GSTT1
21mspi4511.3GSTM1, GSTT1, CYP1A1, CYP2E1
22sulforaphane4511.3GSTM1, CYP1A1, GSTP1, CCND1
23Glutathione11 2412.3GSTP1, GSTT1, GSTM1, GSTM3
24benzo(a)pyrene4511.3GSTT1, GSTP1, GSTM1, CYP1A1
25methylchloride4511.2GSTM1, GSTT1, GSTP1
26trans,trans-muconic acid4511.2CYP2E1, GSTM1, GSTT1
27butadiene monoxide4511.2GSTT1, GSTM1, CYP2E1
28cumene hydroperoxide4511.2GSTM1, GSTT1, GSTP1
29vinylchloride4511.2GSTM1, CYP2E1, GSTT1
30p0024511.2SKP2, ADH1C, GSTM1, GSTT1
31toluene4511.2GSTT1, GSTM1, CYP2E1
32sulfate45 2412.2GSTM1, GSTM3, GSTP1, GSTT1
33debrisoquine4511.2GSTM1, CYP2E1, CYP1A1
341-chloro-24-dinitrobenzene4511.2GSTT1, GSTP1, GSTM1
35dichloromethane4511.2CYP2E1, GSTP1, GSTT1
36troglitazone45 29 60 1114.2CYP1A1, CCND1, SKP2, KRT13
37phenethyl isothiocyanate45 212.1CYP1A1, CCND1, GSTP1
38etoposide45 50 60 1114.1S100A2, CYP2E1, GSTP1
39isoniazid50 45 1113.1CYP2E1, GSTM1, GSTT1
40benzene4511.1GSTT1, GSTM1, CYP2E1
41doxorubicin45 50 1113.0CCND1, TERC, GSTP1, GSTT1, GSTM1
42(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1111.0GSTP1, GSTM1
43dcnb4511.0GSTP1, GSTM1
44n-nitrosomethylbenzylamine4510.9CCND1, CYP2E1
45drugs for treatment of tuberculosis5010.9GSTT1, GSTM1
46n-(2-hydroxyethyl)valine4510.8GSTT1, GSTM1
47ifosfamide45 1111.7GSTM1, GSTP1, GSTT1
482,4,6-trinitrotoluene4510.7GSTM1, GSTP1
49egcg4510.7CYP2E1
50glycidamide4510.4CYP2E1, GSTP1

GO Terms for genes affiliated with Oral Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Oral Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.5GSTM1, CYP2E1, TCN1, ADH1C, GSTM3, GSTT1
2xenobiotic metabolic processGO:00680511.5GSTM1, CYP1A1, CYP2E1, ADH1C, GSTP1, GSTT1
3glutathione derivative biosynthetic processGO:190168711.1GSTM3, GSTP1, GSTT1, GSTM1
4glutathione metabolic processGO:00674911.1GSTP1, GSTT1, GSTM1, GSTM3
5cellular detoxification of nitrogen compoundGO:07045810.8GSTM1, GSTM3
6nitrobenzene metabolic processGO:01891610.7GSTM3, GSTM1
7response to organonitrogen compoundGO:01024310.7CYP2E1, CCND1
8response to drugGO:04249310.6GSTT1, CCND1, CYP1A1, CYP2E1
9xenobiotic catabolic processGO:04217810.6GSTM3, GSTM1

Molecular functions related to Oral Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.8GSTP1, GSTT1, GSTM1, GSTM3
2enzyme bindingGO:01989910.7CCND1, CYP1A1, CYP2E1, GSTM3, GSTM1
3glutathione bindingGO:04329510.7GSTM1, GSTM3

Products for genes affiliated with Oral Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet