MCID: ORL005
MIFTS: 55

Oral Candidiasis malady

Oral diseases category

Summaries for Oral Candidiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards: Oral Candidiasis, also known as candidiasis of mouth, is related to candidiasis and bacterial vaginosis. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Beta defensins and Packaging Of Telomere Ends. The drugs flucytosine and chlorhexidine and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:63 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

oral candidiasis 8 44 60
candidiasis of mouth 8
oral moniliasis 8
thrush, oral 8
candidiasis 60
thrush 8


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Disease Ontology8 DOID:14262
MeSH34 D002180
NCIt39 C28137
ICD9CM27 112.0

Related Diseases for Oral Candidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.8SKAP2, HTN3, APCS, ST5, DEFB4A, SH2D1A
2bacterial vaginosis30.6SLPI, LTF
3leukemia30.4B2M, MPO, SH2D1A, CD9, SLPI, TMPO
4herpes simplex30.2TMPO, SLPI
5pneumonia30.2MPO, MT-CYB, DEFB1, DEFB4A, CD9, SLPI
6hepatitis30.1TMPO
7tuberculosis30.0CD9, DEFB4A
8peritonitis30.0B2M, MPO, SLPI
9crohn's disease30.0LTF
10multiple myeloma30.0B2M
11meningitis30.0ST5
12psoriasis29.9SLPI, LTF, DEFB4A
13asthma29.9DEFB4A, DEFB1, MPO
14vasculitis29.9LTF, SH2D1A, MPO
15acne29.6PSTPIP1
16neutropenia29.6MPO
17deficiency anemia29.6B2M, TMPO
18influenza29.6LTF, CD9, TMPO
19pancreatitis29.6LTF, MPO
20arthritis29.6PSTPIP1, B2M, MPO, LTF
21cystic fibrosis29.6MPO, DEFB1, DEFB103B, DEFB4A, LTF, SLPI
22chronic mucocutaneous candidiasis11.0
23acquired immunodeficiency syndrome10.4
24vulvovaginitis10.3
25vulvovaginal candidiasis10.3
26aspergillosis10.3
27candidiasis, familial, 2, autosomal recessive10.3
28vaginitis10.3
29acute leukemia10.3
30diabetes mellitus10.3
31idiopathic cutaneous and mucosal candidiasis10.3
32autoimmune polyendocrine syndrome type 110.3
33invasive aspergillosis10.2
34candidal paronychia10.2
35esophageal cancer10.2
36pharyngitis10.1
37denture stomatitis10.1
38dermatitis10.1
39stomatitis10.1
40alopecia10.1
41laryngitis10.1
42familial candidiasis 610.1
43autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1
44hypoparathyroidism10.1
45dermatophytosis10.1
46hypothyroidism10.1
47keratitis10.1
48t cell deficiency10.1
49candidiasis familial chronic mucocutaneous, autosomal recessive10.1
50familial candidiasis 510.1

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Clinical Features for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oral Candidiasis

Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Search CenterWatch for Oral Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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32MalaCards
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MalaCards organs/tissues related to Oral Candidiasis:

32
Tongue, Colon, Liver, T cells, Kidney, Testes, Myeloid

Animal Models for Oral Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oral Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.8B2M, MPO, SH2D1A, LTF, CD9, SKAP2
2MP:00053876.2SLPI, APCS, PSTPIP1, B2M, MPO, DEFB1

Publications for Oral Candidiasis

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50PubMed
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Articles related to Oral Candidiasis:

(show top 50)    (show all 412)
idTitleAuthorsYear
1
Efficacy of Fungiflora Y staining for the diagnosis of oral erythematous candidiasis. (22582792)
2013
2
An oral vaccine against candidiasis generated by a yeast molecular display system. (23873745)
2013
3
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
4
Oral chronic hyperplastic candidiasis associated with juvenile dermatomyositis. (22930057)
2012
5
Diagnosing hyperplastic oral candidiasis. (22753677)
2012
6
Preparation of mucoadhesive oral patches containing tetracycline hydrochloride and carvacrol for treatment of local mouth bacterial infections and candidiasis. (21617783)
2011
7
Azole susceptibility and resistance in Candida isolates from oral candidiasis and oral colonization in HIV positive patients. (23781644)
2011
8
Cytological analysis of the epithelial cells in patients with oral candidiasis. (20202111)
2011
9
Disseminated histoplasmosis with concurrent oral candidiasis in an Eclectus parrot (Eclectus roratus). (21500041)
2011
10
Oral medicine case book 24. Chronic hyperplastic candidiasis. (20527582)
2010
11
Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children. (19615660)
2009
12
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
13
Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. (18240892)
2007
14
Interventions for preventing oral candidiasis for patients with cancer receiving treatment. (17253497)
2007
15
Association of asymptomatic oral candidal carriage, oral candidiasis and CD4 lymphocyte count in HIV-positive patients in China. (16390467)
2006
16
Predictive value of oral candidiasis as a marker of progression to AIDS. (15627906)
2005
17
Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study. (14970779)
2004
18
New sensitive method for the measurement of lysozyme and lactoferrin to explore mucosal innate immunity. Part II: time-resolved immunofluorometric assay used in HIV patients with oral candidiasis. (12666997)
2003
19
Oral candidiasis. (14519029)
2003
20
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: cochrane systematic review. (12214838)
2002
21
Oral candidiasis. (12185216)
2002
22
Oral versus intra-vaginal imidazole and triazole anti-fungal agents for the treatment of uncomplicated vulvovaginal candidiasis (thrush): a systematic review. (11843377)
2002
23
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
24
Antifungal efficacy of GM237354, a sordarin derivative, in experimental oral candidiasis in immunosuppressed rats. (11257009)
2001
25
Serum and salivary antibodies to a mycobacterial 65-kDa stress protein are elevated in HIV-positive patients and modified by oral candidiasis. (11154418)
2000
26
Myeloperoxidase deficiency associated with atypical oral candidiasis: A clinical report. (10479248)
1999
27
Effects of amphetamine on development of oral candidiasis in rats. (10391856)
1999
28
Oral candidiasis: a morbid sequela of anticancer therapy. (9667209)
1998
29
Inhaled steroids and oral candidiasis. Help your patient avoid this troubling symptom. (9616586)
1998
30
A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis. (9207371)
1997
31
Candidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapy. (9269016)
1997
32
Immunocompetent cells in oral candidiasis of HIV-infected patients: an immunohistochemical and electron microscopical study. (9467350)
1997
33
Anterior uveitis in a patient with AIDS who was treated with terbinafine for oral candidiasis: a potential drug-induced reaction. (9314484)
1997
34
Locally invasive oral candidiasis mimicking zygomycosis in a patient with diabetic ketoacidosis. (8850487)
1996
35
Use of terbinafine in HIV-positive subjects: pilot studies in onychomycosis and oral candidiasis. (8763464)
1996
36
The impact of oral contraception on vulvovaginal candidiasis. (7628203)
1995
37
Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance. (7942935)
1994
38
Oral candidiasis. History, classification, and clinical presentation. (7936588)
1994
39
Progression to AIDS in HIV-infected homosexual and bisexual men with hairy leukoplakia and oral candidiasis. (1543572)
1992
40
Candida albicans biotypes in human immunodeficiency virus type 1-infected patients with oral candidiasis before and after antifungal therapy. (1679764)
1991
41
Dermatitis of the face, yellow toe nail changes, hairy leukoplakia and oral candidiasis are clinical indicators of progression to AIDS/opportunistic infection in patients with HIV infection. (2587953)
1989
42
The use of Calcofluor white in the histopathologic diagnosis of oral candidiasis. (2438625)
1987
43
Oral candidiasis. (3315343)
1987
44
Immunodeficiency manifested by oral candidiasis and bacterial septicemia in foals. (4008299)
1985
45
Natamycin and nystatin for treatment of oral candidiasis during and after radiotherapy. (6607989)
1984
46
Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. (6738653)
1984
47
Oral candidiasis and AIDS. (6493294)
1984
48
Severe chronic mucocutaneous candidiasis. Favourable response to oral therapy with ketoconazole. (6298584)
1983
49
Effects of triamcinolone acetonide on experimental oral candidiasis in monkeys. (1056095)
1975
50
Ultrastructural features of host-parasite relationship in oral candidiasis. (5686004)
1968

Genetic Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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53Reactome
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Pathways related to Oral Candidiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4DEFB4A, DEFB103B, DEFB1
2
Hide members
9.2LTF, B2M, APCS

Compounds for genes affiliated with Oral Candidiasis

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4410.4B2M, LTF
2iohexol4410.3B2M, LTF
3fenton4410.3MT-CYB
4naphthol as-d chloroacetate4410.3MPO, LTF
5hypothiocyanite44 2411.3LTF, MPO
6pmma4410.2LTF, B2M, HTN3
7fluconazole44 1111.2HTN3, SH2D1A, LTF
8thiocyanate44 2411.2MPO, LTF
9iopentol4410.1SLPI, B2M
10ampicillin44 1111.1LTF, MPO
11sodium azide4410.1HTN3, MPO
12hypoxanthine44 11 2412.1B2M, MPO, LTF
13cytochalasin b4410.0LTF, MT-CYB, MPO
14vitamin b124410.0LTF, MPO, B2M
15chloramine t449.9SLPI, MPO
16neopterin449.9B2M, LTF, CD9
17hbd2449.8DEFB4A, DEFB103B, DEFB1
18methacholine44 1110.8SLPI, LTF, MPO
19dextran sulfate449.8MPO, LTF, CD9
20pentoxifylline44 1110.8CD9, LTF, MPO
21whey449.7SLPI, LTF
22zidovudine44 1110.7TMPO, CD9, B2M
23indomethacin44 59 28 1112.7B2M, MPO, LTF, TMPO
24nacl449.7DEFB1, DEFB4A, LTF, SLPI
25sulfamethoxazole44 49 1111.7MUC7, CD9
26succinate449.7B2M, MT-CYB, LTF, SLPI
27leukotriene b444 59 2411.6MPO, LTF, SLPI
28rantes449.6SLPI, CD9, DEFB4A
29uric acid44 2410.5SLPI, CD9, B2M
30histamine44 28 2411.4SLPI, LTF, DEFB4A, MPO
31paraffin449.4B2M, MPO, DEFB4A, LTF, CD9
32creatinine449.3B2M, MPO, MT-CYB, LTF, SLPI
33iron44 2410.1B2M, MT-CYB, LTF, CD9, SLPI
34serine449.1PSTPIP1, B2M, MPO, MT-CYB, LTF, MUC7
35indinavir44 49 1111.1SLPI, SKAP2, APCS
36genistein44 28 59 2 11 2414.1SLPI, CD9, DEFB4A, B2M
37heparin44 28 11 2412.0MPO, DEFB4A, LTF, CD9, SLPI
38ascorbic acid44 2410.0MPO, MT-CYB, LTF, CD9, SLPI
39aspartate448.9B2M, MT-CYB, LTF, SKAP2, SLPI, TMPO
40cyclosporin a44 28 5910.9B2M, LTF, SLPI, TMPO
41dexamethasone44 49 28 1111.8SLPI, LTF, DEFB4A, DEFB103B, DEFB1
42glucose448.7B2M, MT-CYB, DEFB1, CD9, SLPI, TMPO
43saquinavir44 119.6APCS, CD9, SKAP2, SLPI
44nitric oxide44 11 2410.4TMPO, SLPI, CD9, MT-CYB, MPO
45retinoic acid44 249.3B2M, MPO, DEFB1, DEFB4A, LTF, MUC7
46tyrosine448.1PSTPIP1, DEFB4A, SH2D1A, CD9, SKAP2, SLPI
47cysteine448.1HTN3, B2M, DEFB103B, DEFB4A, LTF, MUC7
48anti-fungal447.6SLPI, HTN3, APCS, DEFB103B, DEFB4A, LTF
49calcium44 49 11 249.6HTN3, APCS, B2M, MPO, MT-CYB, DEFB103B

GO Terms for genes affiliated with Oral Candidiasis

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16Gene Ontology
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Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7MUC7, DEFB4A, DEFB1
2extracellular regionGO:0055767.4SLPI, HTN3, APCS, B2M, DEFB1, DEFB4A

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to fungusGO:0508329.9MPO, HTN3
2defense response to bacteriumGO:0427429.3LTF, DEFB4A, DEFB1, HTN3

Products for genes affiliated with Oral Candidiasis

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Sources for Oral Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet