MCID: ORL005
MIFTS: 58

Oral Candidiasis malady

Infectious diseases, Oral diseases categories
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Summaries for Oral Candidiasis

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CDC:3 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards based summary: Oral Candidiasis, also known as candidiasis of mouth, is related to candidiasis and acquired immunodeficiency syndrome. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Lymphocyte Signaling and Defensins. The drugs flucytosine and itraconazole and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:65 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
See all sources

Oral Candidiasis, Aliases & Descriptions:

Name: Oral Candidiasis 8 44 62
Candidiasis of Mouth 8 62
Oral Moniliasis 8
 
Thrush, Oral 8
Candidiasis 62
Thrush 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:14262
NCIt39 C28137
MeSH34 D002180
ICD9CM27 112.0

Related Diseases for Oral Candidiasis

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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.8LTF, SKAP2, HTN3, APCS, SH2D1A, DEFB4A
2acquired immunodeficiency syndrome31.1B2M
3asthma30.2DEFB1, DEFB4A, MPO
4pneumonia29.9DEFB1, MPO, CD9, SLPI, DEFB4A
5psoriasis29.8DEFB4A, SLPI, LTF
6leukemia29.5CD9, SLPI, B2M, SH2D1A, TMPO, MPO
7leukoplakia10.6
8hiv/aids10.4
9tonsillitis10.3DEFB4A, DEFB1
10diabetes mellitus10.3
11duodenal ulcer10.3DEFB4A, DEFB1
12periodontal disease10.3MPO, LTF
13otitis media10.3DEFB1, LTF
14amyloid tumor10.3LTF, B2M
15churg-strauss syndrome10.3MPO, LTF
16acute leukemia10.3
17hiv-110.3
18cholesteatoma10.3DEFB1, DEFB4A
19polyarteritis nodosa10.3LTF, MPO
20gastritis10.2DEFB4A, DEFB1, LTF
21bacterial vaginosis10.2SLPI, LTF
22pharyngitis10.2
23dermatitis10.2
24stomatitis10.2
25chediak-higashi syndrome10.2MPO, SH2D1A
26secondary hyperparathyroidism of renal origin10.2SLPI, B2M
27hypersensitivity reaction type ii disease10.1B2M, MPO, LTF
28herpes zoster10.1TMPO, CD9
29bronchiectasis10.1SLPI, MPO
30vasculitis10.1LTF, MPO, SH2D1A
31chronic kidney failure10.0SLPI, LTF, B2M
32acute myeloid leukemia10.0
33crohn's disease10.0
34multiple myeloma10.0
35myasthenia gravis10.0
36systemic lupus erythematosus10.0
37median rhomboid glossitis10.0
38diabetic ketoacidosis10.0
39esophageal candidiasis10.0
40oral squamous cell carcinoma10.0
41chikungunya10.0
42tinea pedis10.0
43cryptococcosis10.0
44cheilitis10.0
45diarrhea10.0
46esophagitis10.0
47histoplasmosis10.0
48lupus erythematosus10.0
49lymphadenitis10.0
50meningitis10.0

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Symptoms for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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MalaCards organs/tissues related to Oral Candidiasis:

32
Tongue, Colon, Kidney, Liver, Myeloid, T cells, Neutrophil

Animal Models for Oral Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Oral Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.8DEFB1, B2M, SH2D1A, APCS, MPO, SKAP2
2MP:00053976.4B2M, SH2D1A, APCS, MPO, TMPO, SKAP2

Publications for Oral Candidiasis

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Articles related to Oral Candidiasis:

(show top 50)    (show all 362)
idTitleAuthorsYear
1
Prevalence of oral candidiasis in HIV/AIDS children in highly active antiretroviral therapy-era. A literature analysis. (25156369)
2014
2
Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasis. (24752272)
2014
3
Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults. (23123068)
2013
4
Clinical and microbiological diagnosis of oral candidiasis. (24455095)
2013
5
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
6
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. (21859389)
2012
7
Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis. (21788726)
2011
8
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (20614427)
2010
9
Oral candidiasis of HIV-infected children undergoing sequential HIV therapies. (18651304)
2009
10
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
11
Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. (19089255)
2008
12
Microbiological and immunological features of oral candidiasis. (17704633)
2007
13
Oral candidiasis infections with limited clinical findings. (16884077)
2006
14
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
15
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
16
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. (15599347)
2005
17
Interventions for preventing oral candidiasis for patients with cancer receiving treatment. (15495065)
2004
18
Self-care intervention to reduce oral candidiasis recurrences in HIV-seropositive persons: a pilot study. (15151689)
2004
19
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. (14731170)
2004
20
Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. (12839324)
2003
21
Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. (12506950)
2002
22
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)
2002
23
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. (11805777)
2002
24
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (11869615)
2002
25
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: cochrane systematic review. (12214838)
2002
26
Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. (12058869)
2002
27
CD4 lymphocyte percentage vs CD4 lymphocyte count as an immunological marker of oral candidiasis in HIV-infected patients. (11495199)
2001
28
Increased serum and salivary immunoglobulins against Candida albicans in HIV-infected patients with oral candidiasis. (11506465)
2001
29
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
30
The influence of different risk behaviors in the appearance of oral candidiasis in aids patients. (11507541)
2000
31
Oral candidiasis, switching and antifungal resistance. (12608245)
2000
32
Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis. (10992484)
2000
33
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
34
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
35
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. (9143608)
1997
36
Ketoconazole resistant oral candidiasis in HIV-infected patients. (9247940)
1997
37
Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient. (8735114)
1996
38
Omeprazole as a cause of oral candidiasis. (7632080)
1995
39
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
40
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. (8027327)
1994
41
Host factors associated with HIV-related oral candidiasis. A review. (1532236)
1992
42
Acute oral candidiasis during febrile episodes in immunocompromised patients with haematologic malignancies. (2196672)
1990
43
Oral candidiasis in terminal illness. (3679809)
1987
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
46
Clinical diagnosis and treatment of oral candidiasis. (3858462)
1985
47
Natamycin and nystatin for treatment of oral candidiasis during and after radiotherapy. (6607989)
1984
48
Prophylaxis of oral candidiasis with clotrimazole troches. (6365008)
1984
49
A new approach to the use of antifungal agents in infants with persistent oral candidiasis. (7452393)
1981
50
Oral candidiasis. (701536)
1978

Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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Compounds for genes affiliated with Oral Candidiasis

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Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4410.3LTF, B2M
2iohexol4410.2B2M, LTF
3naphthol as-d chloroacetate4410.2LTF, MPO
4hypothiocyanite44 2411.1LTF, MPO
5pmma4410.1LTF, HTN3, B2M
6iopentol4410.1B2M, SLPI
7fluconazole44 1111.1HTN3, LTF, SH2D1A
8thiocyanate44 2411.1MPO, LTF
9ampicillin44 1111.0LTF, MPO
10sodium azide4410.0HTN3, MPO
11hypoxanthine44 24 1111.9LTF, MPO, B2M
12vitamin b12449.9B2M, MPO, LTF
13chloramine t449.8SLPI, MPO
14neopterin449.8B2M, LTF, CD9
15succinate449.8B2M, LTF, SLPI
16whey449.7SLPI, LTF
17methacholine44 50 1111.7MPO, SLPI, LTF
18dextran sulfate449.7LTF, MPO, CD9
19pentoxifylline44 1110.7CD9, LTF, MPO
20zidovudine44 50 1111.6TMPO, CD9, B2M
21leukotriene b444 61 2411.6LTF, MPO, SLPI
22nacl449.6LTF, SLPI, DEFB1, DEFB4A
23hbd2449.6DEFB4A, DEFB1, DEFB103B
24heparan sulfate44 2410.5B2M, DEFB1, LTF
25indomethacin44 28 61 1112.5B2M, MPO, LTF, TMPO
26cyclophosphamide44 50 1111.5B2M, MPO, LTF
27hyaluronic acid44 2410.5LTF, B2M, SLPI
28mannose449.5LTF, DEFB4A, CD9
29uric acid44 2410.5B2M, SLPI, CD9
30histamine44 28 2411.4LTF, MPO, SLPI, DEFB4A
31cyclosporin a44 28 6111.3TMPO, B2M, LTF, SLPI
32indinavir44 50 1111.3SLPI, SKAP2, APCS
33rantes449.3SLPI, CD9, DEFB1, DEFB4A
34genistein44 28 61 2 24 1114.2B2M, SLPI, CD9, DEFB4A
35paraffin449.2DEFB4A, B2M, MPO, CD9, LTF
36endotoxin449.1DEFB4A, SLPI, LTF
37ascorbic acid44 2410.1LTF, CD9, MPO, SLPI
38creatinine449.1B2M, MPO, SLPI, LTF
39pge2449.0MPO, LTF, B2M, SLPI, TMPO
40aspartate449.0LTF, SKAP2, TMPO, B2M, SLPI
41heparin44 28 24 1111.9LTF, DEFB4A, MPO, CD9, SLPI
42iron44 249.9SLPI, CD9, B2M, MPO, LTF
43saquinavir44 119.8APCS, SKAP2, CD9, SLPI
44glucose448.7SLPI, DEFB1, B2M, TMPO, CD9
45dexamethasone44 50 28 1111.7DEFB103B, DEFB1, LTF, SLPI, DEFB4A
46tyrosine448.3SH2D1A, TMPO, SKAP2, CD9, DEFB4A, SLPI
47retinoic acid44 249.0B2M, MUC7, DEFB1, SLPI, LTF, DEFB4A
48cysteine447.7CD9, HTN3, MUC7, B2M, DEFB103B, DEFB4A
49anti-fungal447.4MUC7, SKAP2, HTN3, DEFB4A, APCS, LTF
50calcium44 50 24 119.6DEFB4A, SLPI, CD9, HTN3, TMPO, MPO

GO Terms for genes affiliated with Oral Candidiasis

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Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3DEFB4A, DEFB1, MUC7
2extracellular regionGO:0055768.5DEFB4A, DEFB1, B2M, APCS, HTN3, LTF
3extracellular vesicular exosomeGO:0700627.4B2M, APCS, MPO, MUC7, CD9, SLPI

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retina homeostasisGO:0018959.9LTF, B2M
2defense response to bacteriumGO:0427429.6HTN3, DEFB1, DEFB4A
3defense response to fungusGO:0508329.5HTN3, MPO

Products for genes affiliated with Oral Candidiasis

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Sources for Oral Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet