MCID: ORL005
MIFTS: 55

Oral Candidiasis malady

Oral diseases category

Summaries for Oral Candidiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards: Oral Candidiasis, also known as candidiasis of mouth, is related to candidiasis and bacterial vaginosis. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Beta defensins and Packaging Of Telomere Ends. The drugs flucytosine and chlorhexidine and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:63 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

oral candidiasis 8 44 60
candidiasis of mouth 8
oral moniliasis 8
thrush, oral 8
candidiasis 60
thrush 8


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Disease Ontology8 DOID:14262
MeSH34 D002180
NCIt39 C28137
ICD9CM27 112.0

Related Diseases for Oral Candidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.8SKAP2, HTN3, APCS, ST5, DEFB4A, SH2D1A
2bacterial vaginosis30.6SLPI, LTF
3leukemia30.4B2M, MPO, SH2D1A, CD9, SLPI, TMPO
4herpes simplex30.2TMPO, SLPI
5pneumonia30.2MPO, MT-CYB, DEFB1, DEFB4A, CD9, SLPI
6hepatitis30.1TMPO
7tuberculosis30.0CD9, DEFB4A
8peritonitis30.0B2M, MPO, SLPI
9crohn's disease30.0LTF
10multiple myeloma30.0B2M
11meningitis30.0ST5
12psoriasis29.9SLPI, LTF, DEFB4A
13asthma29.9DEFB4A, DEFB1, MPO
14vasculitis29.9LTF, SH2D1A, MPO
15acne29.6PSTPIP1
16neutropenia29.6MPO
17deficiency anemia29.6B2M, TMPO
18influenza29.6LTF, CD9, TMPO
19pancreatitis29.6LTF, MPO
20arthritis29.6PSTPIP1, B2M, MPO, LTF
21cystic fibrosis29.6MPO, DEFB1, DEFB103B, DEFB4A, LTF, SLPI
22chronic mucocutaneous candidiasis11.0
23acquired immunodeficiency syndrome10.4
24vulvovaginitis10.3
25vulvovaginal candidiasis10.3
26aspergillosis10.3
27candidiasis, familial, 2, autosomal recessive10.3
28vaginitis10.3
29acute leukemia10.3
30diabetes mellitus10.3
31idiopathic cutaneous and mucosal candidiasis10.3
32autoimmune polyendocrine syndrome type 110.3
33invasive aspergillosis10.2
34candidal paronychia10.2
35esophageal cancer10.2
36pharyngitis10.1
37denture stomatitis10.1
38dermatitis10.1
39stomatitis10.1
40alopecia10.1
41laryngitis10.1
42familial candidiasis 610.1
43autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1
44hypoparathyroidism10.1
45dermatophytosis10.1
46hypothyroidism10.1
47keratitis10.1
48t cell deficiency10.1
49candidiasis familial chronic mucocutaneous, autosomal recessive10.1
50familial candidiasis 510.1

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Clinical Features for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oral Candidiasis

Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Search CenterWatch for Oral Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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32MalaCards
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MalaCards organs/tissues related to Oral Candidiasis:

32
Tongue, Colon, Liver, T cells, Testes, Kidney, Myeloid

Animal Models for Oral Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oral Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.8B2M, MPO, SH2D1A, LTF, CD9, SKAP2
2MP:00053876.2SLPI, APCS, PSTPIP1, B2M, MPO, DEFB1

Publications for Oral Candidiasis

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Sources:
50PubMed
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Articles related to Oral Candidiasis:

(show top 50)    (show all 412)
idTitleAuthorsYear
1
Attitudes, subjective norms, and intention to perform routine oral examination for oropharyngeal candidiasis as perceived by primary health-care providers in Nairobi Province. (22762414)
2013
2
Managing patients with oral candidiasis. (24309041)
2013
3
Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients. (22730912)
2012
4
New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. (21346738)
2011
5
Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. (21788462)
2011
6
Disseminated cryptococcosis and fluconazole resistant oral candidiasis in a patient with acquired immunodeficiency syndrome (AIDS). (21045363)
2010
7
Conventional and alternative antifungal therapies to oral candidiasis. (24031562)
2010
8
Protective effects of farnesol against oral candidiasis in mice. (18667031)
2008
9
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
10
Oral and maxillofacial pathology case of the month. Oral candidiasis associated with inhaled corticosteroid use. (16903436)
2006
11
RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients. (16519012)
2006
12
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis. (16792733)
2006
13
Oral candidiasis in HIV-infected patients and its relation to CD4 + counts: an adjunct clinical marker of HIV disease progression. (16611459)
2006
14
Efficacy of garlic paste in oral candidiasis. (15970035)
2005
15
Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model. (15150327)
2004
16
Protective effects of human saliva on experimental murine oral candidiasis. (15365870)
2004
17
Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. (12839324)
2003
18
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. (11805777)
2002
19
Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis. an immunohistochemical study. (12389997)
2002
20
Levamisole aids in treatment of refractory oral candidiasis in two patients with thymoma associated with myasthenia gravis: report of two cases. (12479622)
2002
21
Carriage frequency, intensity of carriage, and strains of oral yeast species vary in the progression to oral candidiasis in human immunodeficiency virus-positive individuals. (11825940)
2002
22
Fluconazole mouthrinses for oral candidiasis in postirradiation, transplant, and other patients. (12142873)
2002
23
Antifungal activities of two new azasordarins, GW471552 and GW471558, in experimental models of oral and vulvovaginal candidiasis in immunosuppressed rats. (11709301)
2001
24
Pseudotumoral hyperplastic form of oral candidiasis. (11507568)
2000
25
The treatment of oral candidiasis in a cohort of South African HIV/AIDS patients. (16892568)
1999
26
Picture this. Oral candidiasis. (10690047)
1999
27
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. (9143608)
1997
28
Pharmacokinetics of itraconazole (oral solution) in two groups of human immunodeficiency virus-infected adults with oral candidiasis. (9371367)
1997
29
Simultaneous carriage of Candida albicans strains from HIV-infected patients with oral candidiasis: multilocus enzyme electrophoresis analysis. (8998997)
1996
30
Initial management of recurrent vulvovaginal candidiasis with oral ketoconazole and topical clotrimazole. (7966041)
1994
31
Prevalence of diabetes mellitus in odontogenic infections and oral candidiasis: an analysis of neutrophil suppression. (8391079)
1993
32
The prevalence of oral candidiasis in HIV-infected individuals and dental attenders in Edinburgh. (8301607)
1993
33
Molecular epidemiology of recurrent oral candidiasis in human immunodeficiency virus-positive patients: evidence for two patterns of recurrence. (8335986)
1993
34
Oral candidiasis and HIV infection. (1633087)
1992
35
Once-weekly oral doses of fluconazole 150 mg in the treatment of tinea corporis/cruris and cutaneous candidiasis. (1486705)
1992
36
Immunodiagnosis in oral candidiasis. A review. (1408018)
1992
37
Salivary secretion rate, yeast cells, and oral candidiasis in patients with acute leukemia. (2062522)
1991
38
Factors associated with increased frequency of HIV-related oral candidiasis. (1680189)
1991
39
Phase II study of D.651, an oral vaccine designed to prevent recurrences of vulvovaginal candidiasis. (2683457)
1989
40
Oral candidiasis in terminal illness. (3679809)
1987
41
Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate. (3475563)
1987
42
Oral topical steroids and secondary oral candidiasis. (3465924)
1986
43
Familial chronic mucocutaneous candidiasis successfully treated with oral ketoconazole. (6256921)
1981
44
Oral candidiasis: effects of antifungal therapy upon clinical signs and symptoms, salivary antibody, and mucosal adherence of Candida albicans. (7007953)
1981
45
Oral candidiasis. (701536)
1978
46
Hibitane in the treatment of oral candidiasis. (350905)
1977
47
Clotrimazole troches: a new therapeutic approach to oral candidiasis. (797539)
1976
48
Trials of the use of clotrimazole in the treatment of oral candidiasis in newborn babies. (4619453)
1974
49
Chlorhexidine treatment of oral candidiasis in seriously diseased children. (4530603)
1974
50
Chronic oral candidiasis (autosomal recessive inheritance) (three cases). (5477064)
1970

Genetic Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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53Reactome
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Pathways related to Oral Candidiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4DEFB4A, DEFB103B, DEFB1
2
Hide members
9.2LTF, B2M, APCS

Compounds for genes affiliated with Oral Candidiasis

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4410.4B2M, LTF
2iohexol4410.3B2M, LTF
3fenton4410.3MT-CYB
4naphthol as-d chloroacetate4410.3MPO, LTF
5hypothiocyanite44 2411.3LTF, MPO
6pmma4410.2LTF, B2M, HTN3
7fluconazole44 1111.2HTN3, SH2D1A, LTF
8thiocyanate44 2411.2MPO, LTF
9iopentol4410.1SLPI, B2M
10ampicillin44 1111.1LTF, MPO
11sodium azide4410.1HTN3, MPO
12hypoxanthine44 11 2412.1B2M, MPO, LTF
13cytochalasin b4410.0LTF, MT-CYB, MPO
14vitamin b124410.0LTF, MPO, B2M
15chloramine t449.9SLPI, MPO
16neopterin449.9B2M, LTF, CD9
17hbd2449.8DEFB4A, DEFB103B, DEFB1
18methacholine44 1110.8SLPI, LTF, MPO
19dextran sulfate449.8MPO, LTF, CD9
20pentoxifylline44 1110.8CD9, LTF, MPO
21whey449.7SLPI, LTF
22zidovudine44 1110.7TMPO, CD9, B2M
23indomethacin44 59 28 1112.7B2M, MPO, LTF, TMPO
24nacl449.7DEFB1, DEFB4A, LTF, SLPI
25sulfamethoxazole44 49 1111.7MUC7, CD9
26succinate449.7B2M, MT-CYB, LTF, SLPI
27leukotriene b444 59 2411.6MPO, LTF, SLPI
28rantes449.6SLPI, CD9, DEFB4A
29uric acid44 2410.5SLPI, CD9, B2M
30histamine44 28 2411.4SLPI, LTF, DEFB4A, MPO
31paraffin449.4B2M, MPO, DEFB4A, LTF, CD9
32creatinine449.3B2M, MPO, MT-CYB, LTF, SLPI
33iron44 2410.1B2M, MT-CYB, LTF, CD9, SLPI
34serine449.1PSTPIP1, B2M, MPO, MT-CYB, LTF, MUC7
35indinavir44 49 1111.1SLPI, SKAP2, APCS
36genistein44 28 59 2 11 2414.1SLPI, CD9, DEFB4A, B2M
37heparin44 28 11 2412.0MPO, DEFB4A, LTF, CD9, SLPI
38ascorbic acid44 2410.0MPO, MT-CYB, LTF, CD9, SLPI
39aspartate448.9B2M, MT-CYB, LTF, SKAP2, SLPI, TMPO
40cyclosporin a44 28 5910.9B2M, LTF, SLPI, TMPO
41dexamethasone44 49 28 1111.8SLPI, LTF, DEFB4A, DEFB103B, DEFB1
42glucose448.7B2M, MT-CYB, DEFB1, CD9, SLPI, TMPO
43saquinavir44 119.6APCS, CD9, SKAP2, SLPI
44nitric oxide44 11 2410.4TMPO, SLPI, CD9, MT-CYB, MPO
45retinoic acid44 249.3B2M, MPO, DEFB1, DEFB4A, LTF, MUC7
46tyrosine448.1PSTPIP1, DEFB4A, SH2D1A, CD9, SKAP2, SLPI
47cysteine448.1HTN3, B2M, DEFB103B, DEFB4A, LTF, MUC7
48anti-fungal447.6SLPI, HTN3, APCS, DEFB103B, DEFB4A, LTF
49calcium44 49 11 249.6HTN3, APCS, B2M, MPO, MT-CYB, DEFB103B

GO Terms for genes affiliated with Oral Candidiasis

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16Gene Ontology
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Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7MUC7, DEFB4A, DEFB1
2extracellular regionGO:0055767.4SLPI, HTN3, APCS, B2M, DEFB1, DEFB4A

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to fungusGO:0508329.9MPO, HTN3
2defense response to bacteriumGO:0427429.3LTF, DEFB4A, DEFB1, HTN3

Products for genes affiliated with Oral Candidiasis

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Sources for Oral Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet