MCID: ORL005
MIFTS: 53

Oral Candidiasis malady

Oral category

Summaries for Oral Candidiasis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

MalaCards: Oral Candidiasis, also known as candidiasis of mouth, is related to leukoplakia and bacterial vaginosis. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Beta defensins and Packaging Of Telomere Ends. The drugs flucytosine and chlorhexidine and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and liver, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:64 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral


Aliases & Descriptions:

oral candidiasis 8 45 61
candidiasis of mouth 8
oral moniliasis 8
thrush, oral 8
candidiasis 61
thrush 8


External Ids:

Disease Ontology8 DOID:14262
MeSH35 D002180
NCIt40 C28137
ICD9CM27 112.0

Related Diseases for Oral Candidiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia30.9DEFB4A
2bacterial vaginosis30.7SLPI, LTF
3asthma30.2MPO, DEFB1, DEFB4A
4tuberculosis30.1CD9, DEFB4A
5vasculitis29.9SH2D1A, LTF, MPO
6acne29.7PSTPIP1
7deficiency anemia29.7B2M, TMPO
8arthritis29.7PSTPIP1, B2M, LTF, MPO
9cystic fibrosis29.7MPO, DEFB1, DEFB103B, LTF, DEFB4A, SLPI
10sepsis29.7CD9, DEFB4A, LTF, DEFB1, TMPO, MPO
11chronic mucocutaneous candidiasis11.0
12oral cancer10.6
13oral leukoplakia10.6
14acquired immunodeficiency syndrome10.4
15candida glabrata10.4
16aspergillosis10.4
17vulvovaginal candidiasis10.3
18acute leukemia10.3
19candidiasis, familial, 2, autosomal recessive10.3
20autoimmune polyendocrine syndrome type 110.3
21invasive aspergillosis10.2
22vaginitis10.2
23denture stomatitis10.2
24stomatitis10.2
25alopecia10.2
26familial candidiasis 610.2
27autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2
28vulvovaginitis10.1
29candidal paronychia10.1
30hypoparathyroidism10.1
31candidiasis familial chronic mucocutaneous, autosomal recessive10.1
32familial candidiasis 510.1
33familial candidiasis 210.1
34candidiasis, familial, 810.1
35hepatitis c10.1
36systemic lupus erythematosus10.1
37alopecia areata10.1
38autoimmune polyendocrine syndrome10.1
39vaginal discharge10.1
40esophageal candidiasis10.0
41diabetic ketoacidosis10.0
42acute myeloid leukemia10.0
43pharyngitis10.0
44neonatal candidiasis10.0
45tongue cancer10.0
46tinea pedis10.0
47median rhomboid glossitis10.0
48cryptococcosis10.0
49chikungunya10.0
50squamous cell carcinoma10.0

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Clinical Features for Oral Candidiasis

Drugs & Therapeutics for Oral Candidiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Candidiasis

Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Search CenterWatch for Oral Candidiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Oral Candidiasis

Anatomical Context for Oral Candidiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Oral Candidiasis:

33
Colon, Kidney, Liver, Myeloid, T cells, B cells, Tongue

Animal Models for Oral Candidiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Oral Candidiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.8B2M, MPO, SH2D1A, LTF, CD9, SKAP2
2MP:00053876.2SLPI, APCS, PSTPIP1, B2M, MPO, DEFB1

Publications for Oral Candidiasis

Sources:
51PubMed
See all sources

Articles related to Oral Candidiasis:

(show top 50)    (show all 412)
idTitleAuthorsYear
1
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
2
Oral candidiasis in patients with psoriasis: correlation of oral examination and cytopathological evaluation with psoriasis disease severity and treatment. (23384796)
2013
3
Hospital-based emergency department visits with oral candidiasis in the USA. (22769417)
2012
4
The essential oil of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol protect mice from experimental oral candidiasis. (22687476)
2012
5
Oral candidiasis in European hedgehogs. (23223477)
2012
6
Protective effect of an oral natural phytonutrient in recurrent vulvovaginal candidiasis: a 12-month study. (22217987)
2011
7
Oral Candidiasis: Aiding in the Diagnosis of HIV-A Case Report. (22567448)
2011
8
Microbiological screening of Irish patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy reveals persistence of Candida albicans strains, gradual reduction in susceptibility to azoles, and incidences of clinical signs of oral candidiasis without culture evidence. (21367996)
2011
9
Oral fluconazole 150 mg single dose versus intra-vaginal clotrimazole treatment of acute vulvovaginal candidiasis. (22000847)
2011
10
Oral mucous squamous cell carcinoma-an anticipated consequence of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (20304522)
2010
11
A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. (19404692)
2010
12
A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection. (18627504)
2008
13
Prevalence of oral candidiasis in chronic renal failure and renal transplant pediatric patients. (18767464)
2008
14
Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis. (17259500)
2007
15
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (17443513)
2007
16
Review: inhaled corticosteroids increase risk of oral candidiasis, dysphonia, and pharyngitis in persistent asthma. (17905761)
2007
17
Characterization of the immune status of CD8+ T cells in oral lesions of human immunodeficiency virus-infected persons with oropharyngeal Candidiasis. (16760327)
2006
18
Oral candidiasis in pediatric HIV patients. (15887466)
2005
19
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. (14731170)
2004
20
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (14973977)
2004
21
Antifungal treatment with carvacrol and eugenol of oral candidiasis in immunosuppressed rats. (15476054)
2004
22
Review: antifungals absorbed or partially absorbed from the GI tract prevent oral candidiasis in cancer patients receiving treatment. (12614131)
2003
23
Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis. (14632933)
2003
24
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)
2002
25
Review: oral and intravaginal agents are equally effective for treatment of uncomplicated vulvovaginal candidiasis. (12093214)
2002
26
A systematic review of the management of oral candidiasis associated with HIV/AIDS. (12674866)
2002
27
Oral candidiasis most prevalent HIV oral manifestation. (11775275)
2001
28
Pathogenesis, microbiological and clinical aspects of oral candidiasis (candidosis). (11791346)
2001
29
The influence of different risk behaviors in the appearance of oral candidiasis in aids patients. (11507541)
2000
30
Complete response of severe, refractory oral candidiasis to mouthwash containing lactoferrin and lysozyme. (11089630)
2000
31
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
32
Salivary histatins in patients with recurrent oral candidiasis. (9890454)
1999
33
Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. (9662200)
1998
34
Oral candidiasis and SjAPgren's syndrome. (9598890)
1998
35
In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. (8874667)
1996
36
The demonstration of candidal pseudohyphae in salivary smears as a method of early diagnosis of oral candidiasis in patients with acute myeloid leukemia. (9556406)
1996
37
Response to fluconazole by 23 patients with human immunodeficiency virus infection and oral candidiasis: pharmacological and mycological factors. (8843316)
1996
38
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
39
Comparison of a lesion-inducing isolate and a non-lesional isolate of Candida albicans in an immunosuppressed rat model of oral candidiasis. (7517452)
1994
40
Oral candidiasis established in the sialoadenectomised rat. (8445543)
1993
41
Single-dose versus 7 days of fluconazole treatment for oral candidiasis in human immunodeficiency virus-infected patients: a prospective, randomized pilot study. (8228378)
1993
42
Diagnosing and managing oral candidiasis. (1740577)
1992
43
Oral candidiasis in HIV infection: pseudomembranous and erythematous candidiasis show similar rates of progression to AIDS. (1768382)
1991
44
Clinical evaluation of a nystatin pastille for treatment of denture-related oral candidiasis. (2657027)
1989
45
Association of oral candidiasis with diabetic control. (2732344)
1989
46
Drugs in dentistry. Oral candidiasis and steroid inhalers. (3163568)
1988
47
Non-inbred Sprague-Dawley germfree rats as a model for oral candidiasis. (3267964)
1987
48
Efficacy of a new nystatin formulation in oral candidiasis. (3092921)
1986
49
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
50
Sensitivity of Candida albicans from patients with chronic oral candidiasis. (392486)
1979

Genetic Variations for Oral Candidiasis

Expression for genes affiliated with Oral Candidiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

Sources:
54Reactome
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Pathways related to Oral Candidiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4DEFB4A, DEFB103B, DEFB1
2
Hide members
9.2LTF, B2M, APCS

Compounds for genes affiliated with Oral Candidiasis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4510.4B2M, LTF
2iohexol4510.3B2M, LTF
3fenton4510.3MT-CYB
4naphthol as-d chloroacetate4510.3MPO, LTF
5hypothiocyanite45 2411.3LTF, MPO
6pmma4510.2LTF, B2M, HTN3
7fluconazole45 1111.2HTN3, SH2D1A, LTF
8thiocyanate45 2411.2MPO, LTF
9iopentol4510.1SLPI, B2M
10ampicillin45 1111.1LTF, MPO
11sodium azide4510.1HTN3, MPO
12hypoxanthine45 11 2412.1B2M, MPO, LTF
13cytochalasin b4510.0LTF, MT-CYB, MPO
14vitamin b124510.0LTF, MPO, B2M
15chloramine t459.9SLPI, MPO
16neopterin459.9B2M, LTF, CD9
17hbd2459.8DEFB4A, DEFB103B, DEFB1
18methacholine45 1110.8SLPI, LTF, MPO
19dextran sulfate459.8MPO, LTF, CD9
20pentoxifylline45 1110.8CD9, LTF, MPO
21whey459.7SLPI, LTF
22zidovudine45 1110.7TMPO, CD9, B2M
23indomethacin45 60 29 1112.7B2M, MPO, LTF, TMPO
24nacl459.7DEFB1, DEFB4A, LTF, SLPI
25sulfamethoxazole45 50 1111.7MUC7, CD9
26succinate459.7B2M, MT-CYB, LTF, SLPI
27leukotriene b445 60 2411.6MPO, LTF, SLPI
28rantes459.6SLPI, CD9, DEFB4A
29uric acid45 2410.5SLPI, CD9, B2M
30histamine45 29 2411.4SLPI, LTF, DEFB4A, MPO
31paraffin459.4B2M, MPO, DEFB4A, LTF, CD9
32creatinine459.3B2M, MPO, MT-CYB, LTF, SLPI
33iron45 2410.1B2M, MT-CYB, LTF, CD9, SLPI
34serine459.1PSTPIP1, B2M, MPO, MT-CYB, LTF, MUC7
35indinavir45 50 1111.1SLPI, SKAP2, APCS
36genistein45 29 60 2 11 2414.1SLPI, CD9, DEFB4A, B2M
37heparin45 29 11 2412.0MPO, DEFB4A, LTF, CD9, SLPI
38ascorbic acid45 2410.0MPO, MT-CYB, LTF, CD9, SLPI
39aspartate458.9B2M, MT-CYB, LTF, SKAP2, SLPI, TMPO
40cyclosporin a45 29 6010.9B2M, LTF, SLPI, TMPO
41dexamethasone45 50 29 1111.8SLPI, LTF, DEFB4A, DEFB103B, DEFB1
42glucose458.7B2M, MT-CYB, DEFB1, CD9, SLPI, TMPO
43saquinavir45 119.6APCS, CD9, SKAP2, SLPI
44nitric oxide45 11 2410.4TMPO, SLPI, CD9, MT-CYB, MPO
45retinoic acid45 249.3B2M, MPO, DEFB1, DEFB4A, LTF, MUC7
46tyrosine458.1PSTPIP1, DEFB4A, SH2D1A, CD9, SKAP2, SLPI
47cysteine458.1HTN3, B2M, DEFB103B, DEFB4A, LTF, MUC7
48anti-fungal457.6SLPI, HTN3, APCS, DEFB103B, DEFB4A, LTF
49calcium45 50 11 249.6HTN3, APCS, B2M, MPO, MT-CYB, DEFB103B

GO Terms for genes affiliated with Oral Candidiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7MUC7, DEFB4A, DEFB1
2extracellular regionGO:0055767.4SLPI, HTN3, APCS, B2M, DEFB1, DEFB4A

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to fungusGO:0508329.9MPO, HTN3
2defense response to bacteriumGO:0427429.3LTF, DEFB4A, DEFB1, HTN3

Products for genes affiliated with Oral Candidiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Candidiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet