MCID: ORL005
MIFTS: 56

Oral Candidiasis malady

Infectious diseases, Oral diseases categories
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Summaries for Oral Candidiasis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards: Oral Candidiasis, also known as candidiasis of mouth, is related to candidiasis and acquired immunodeficiency syndrome. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Lymphocyte Signaling and Defensins. The drugs ketoconazole and flucytosine and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:65 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral candidiasis 8 45 62
candidiasis of mouth 8
oral moniliasis 8
thrush, oral 8
candidiasis 62
thrush 8


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Disease Ontology8 DOID:14262
ICD9CM27 112.0
NCIt40 C28137
MeSH35 D002180

Related Diseases for Oral Candidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.9LTF, SKAP2, HTN3, APCS, SH2D1A, DEFB4A
2acquired immunodeficiency syndrome30.7B2M
3leukemia30.2CD9, SLPI, B2M, SH2D1A, TMPO, MPO
4pneumonia30.2DEFB1, MPO, CD9, SLPI, DEFB4A
5asthma30.1DEFB1, DEFB4A, MPO
6psoriasis30.0DEFB4A, SLPI, LTF
7leukoplakia10.6
8hiv/aids10.4
9diabetes mellitus10.3
10acute leukemia10.3
11pharyngitis10.2
12dermatitis10.2
13stomatitis10.2
14hiv-110.2
15tonsillitis10.1DEFB4A, DEFB1
16duodenal ulcer10.1DEFB4A, DEFB1
17periodontal disease10.1MPO, LTF
18otitis media10.1DEFB1, LTF
19amyloid tumor10.1LTF, B2M
20churg-strauss syndrome10.1MPO, LTF
21cholesteatoma10.1DEFB1, DEFB4A
22polyarteritis nodosa10.1LTF, MPO
23gastritis10.1DEFB4A, DEFB1, LTF
24bacterial vaginosis10.1SLPI, LTF
25chediak-higashi syndrome10.0MPO, SH2D1A
26secondary hyperparathyroidism of renal origin10.0SLPI, B2M
27hypersensitivity reaction type ii disease10.0B2M, MPO, LTF
28herpes zoster10.0TMPO, CD9
29crohn's disease10.0
30diabetic ketoacidosis10.0
31oral squamous cell carcinoma10.0
32chikungunya10.0
33acute myeloid leukemia10.0
34cryptococcosis10.0
35tinea pedis10.0
36median rhomboid glossitis10.0
37esophageal candidiasis10.0
38cheilitis10.0
39diarrhea10.0
40esophagitis10.0
41histoplasmosis10.0
42lymphadenitis10.0
43meningitis10.0
44multiple myeloma10.0
45myasthenia gravis10.0
46myeloid leukemia10.0
47myeloma10.0
48thymoma10.0
49tongue cancer10.0
50uveitis10.0

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Symptoms for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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33MalaCards
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MalaCards organs/tissues related to Oral Candidiasis:

33
Tongue, Colon, Kidney, Liver, Myeloid, T cells

Animal Models for Oral Candidiasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Oral Candidiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.8B2M, SH2D1A, APCS, MPO, SKAP2, CD9
2MP:00053976.4LTF, B2M, SH2D1A, APCS, MPO, TMPO

Publications for Oral Candidiasis

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52PubMed
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Articles related to Oral Candidiasis:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults. (23123068)
2013
2
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
3
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. (21859389)
2012
4
Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis. (21788726)
2011
5
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (20614427)
2010
6
Oral candidiasis of HIV-infected children undergoing sequential HIV therapies. (18651304)
2009
7
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
8
Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. (19089255)
2008
9
Microbiological and immunological features of oral candidiasis. (17704633)
2007
10
Oral candidiasis infections with limited clinical findings. (16884077)
2006
11
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
12
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
13
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. (15599347)
2005
14
Interventions for preventing oral candidiasis for patients with cancer receiving treatment. (15495065)
2004
15
Self-care intervention to reduce oral candidiasis recurrences in HIV-seropositive persons: a pilot study. (15151689)
2004
16
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. (14731170)
2004
17
Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. (12839324)
2003
18
Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. (12506950)
2002
19
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)
2002
20
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. (11805777)
2002
21
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (11869615)
2002
22
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: cochrane systematic review. (12214838)
2002
23
Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. (12058869)
2002
24
CD4 lymphocyte percentage vs CD4 lymphocyte count as an immunological marker of oral candidiasis in HIV-infected patients. (11495199)
2001
25
Increased serum and salivary immunoglobulins against Candida albicans in HIV-infected patients with oral candidiasis. (11506465)
2001
26
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
27
The influence of different risk behaviors in the appearance of oral candidiasis in aids patients. (11507541)
2000
28
Oral candidiasis, switching and antifungal resistance. (12608245)
2000
29
Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis. (10992484)
2000
30
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
31
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
32
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. (9143608)
1997
33
Ketoconazole resistant oral candidiasis in HIV-infected patients. (9247940)
1997
34
The successful treatment of oral candidiasis (thrush) in a pediatric patient using itraconazole. (9192426)
1997
35
Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient. (8735114)
1996
36
Omeprazole as a cause of oral candidiasis. (7632080)
1995
37
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
38
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. (8027327)
1994
39
Host factors associated with HIV-related oral candidiasis. A review. (1532236)
1992
40
Treatment of refractory oral candidiasis with fluconazole. A case report. (1994321)
1991
41
Acute oral candidiasis during febrile episodes in immunocompromised patients with haematologic malignancies. (2196672)
1990
42
Oral candidiasis: an old disease of growing concern. (2132223)
1990
43
Oral candidiasis in terminal illness. (3679809)
1987
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
46
Clinical diagnosis and treatment of oral candidiasis. (3858462)
1985
47
Natamycin and nystatin for treatment of oral candidiasis during and after radiotherapy. (6607989)
1984
48
Prophylaxis of oral candidiasis with clotrimazole troches. (6365008)
1984
49
A new approach to the use of antifungal agents in infants with persistent oral candidiasis. (7452393)
1981
50
Oral candidiasis. (701536)
1978

Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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50PathCards, 5Cell Signaling Technology, 55Reactome, 30KEGG
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Compounds for genes affiliated with Oral Candidiasis

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4510.3LTF, B2M
2iohexol4510.2B2M, LTF
3naphthol as-d chloroacetate4510.2LTF, MPO
4hypothiocyanite45 2411.1LTF, MPO
5pmma4510.1LTF, HTN3, B2M
6iopentol4510.1B2M, SLPI
7fluconazole45 1111.1HTN3, LTF, SH2D1A
8thiocyanate45 2411.1MPO, LTF
9ampicillin45 1111.0LTF, MPO
10sodium azide4510.0HTN3, MPO
11hypoxanthine45 24 1111.9LTF, MPO, B2M
12vitamin b12459.9B2M, MPO, LTF
13chloramine t459.8SLPI, MPO
14neopterin459.8B2M, LTF, CD9
15succinate459.8B2M, LTF, SLPI
16whey459.7SLPI, LTF
17methacholine45 51 1111.7MPO, SLPI, LTF
18dextran sulfate459.7LTF, MPO, CD9
19pentoxifylline45 1110.7CD9, LTF, MPO
20zidovudine45 51 1111.6TMPO, CD9, B2M
21leukotriene b445 61 2411.6LTF, MPO, SLPI
22nacl459.6LTF, SLPI, DEFB1, DEFB4A
23hbd2459.6DEFB4A, DEFB1, DEFB103B
24heparan sulfate45 2410.5B2M, DEFB1, LTF
25indomethacin45 29 61 1112.5B2M, MPO, LTF, TMPO
26cyclophosphamide45 51 1111.5B2M, MPO, LTF
27hyaluronic acid45 2410.5LTF, B2M, SLPI
28mannose459.5LTF, DEFB4A, CD9
29uric acid45 2410.5B2M, SLPI, CD9
30histamine45 29 2411.4LTF, MPO, SLPI, DEFB4A
31cyclosporin a45 29 6111.3TMPO, B2M, LTF, SLPI
32indinavir45 51 1111.3SLPI, SKAP2, APCS
33rantes459.3SLPI, CD9, DEFB1, DEFB4A
34genistein45 29 61 3 24 1114.2B2M, SLPI, CD9, DEFB4A
35paraffin459.2DEFB4A, B2M, MPO, CD9, LTF
36endotoxin459.1DEFB4A, SLPI, LTF
37ascorbic acid45 2410.1LTF, CD9, MPO, SLPI
38creatinine459.1B2M, MPO, SLPI, LTF
39pge2459.0MPO, LTF, B2M, SLPI, TMPO
40aspartate459.0LTF, SKAP2, TMPO, B2M, SLPI
41heparin45 29 24 1111.9LTF, DEFB4A, MPO, CD9, SLPI
42iron45 249.9SLPI, CD9, B2M, MPO, LTF
43saquinavir45 119.8APCS, SKAP2, CD9, SLPI
44glucose458.7SLPI, DEFB1, B2M, TMPO, CD9
45dexamethasone45 51 29 1111.7DEFB103B, DEFB1, LTF, SLPI, DEFB4A
46tyrosine458.3SH2D1A, TMPO, SKAP2, CD9, DEFB4A, SLPI
47retinoic acid45 249.0B2M, MUC7, DEFB1, SLPI, LTF, DEFB4A
48cysteine457.7CD9, HTN3, MUC7, B2M, DEFB103B, DEFB4A
49anti-fungal457.4MUC7, SKAP2, HTN3, DEFB4A, APCS, LTF
50calcium45 51 24 119.6DEFB4A, SLPI, CD9, HTN3, TMPO, MPO

GO Terms for genes affiliated with Oral Candidiasis

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16Gene Ontology
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Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3DEFB4A, DEFB1, MUC7
2extracellular regionGO:0055768.5LTF, HTN3, APCS, B2M, DEFB1, DEFB4A
3extracellular vesicular exosomeGO:0700627.4LTF, SLPI, CD9, MUC7, MPO, APCS

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retina homeostasisGO:0018959.9LTF, B2M
2defense response to bacteriumGO:0427429.6HTN3, DEFB1, DEFB4A
3defense response to fungusGO:0508329.5HTN3, MPO

Products for genes affiliated with Oral Candidiasis

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  • Antibodies
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  • Lysates
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Sources for Oral Candidiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet