MCID: ORL005
MIFTS: 56

Oral Candidiasis malady

Infectious diseases, Oral diseases categories

Summaries for Oral Candidiasis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards: Oral Candidiasis, also known as candidiasis of mouth, is related to candidiasis and acquired immunodeficiency syndrome. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Lymphocyte Signaling and Defensins. The drugs ketoconazole and flucytosine and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:66 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral candidiasis 9 46 63
candidiasis of mouth 9
oral moniliasis 9
thrush, oral 9
candidiasis 63
thrush 9


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Disease Ontology9 DOID:14262
ICD9CM28 112.0
NCIt41 C28137
MeSH36 D002180

Related Diseases for Oral Candidiasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.9LTF, SKAP2, HTN3, APCS, SH2D1A, DEFB4A
2acquired immunodeficiency syndrome30.7B2M
3leukemia30.2CD9, SLPI, B2M, SH2D1A, TMPO, MPO
4pneumonia30.2DEFB1, MPO, CD9, SLPI, DEFB4A
5asthma30.1DEFB1, DEFB4A, MPO
6psoriasis30.0DEFB4A, SLPI, LTF
7leukoplakia10.6
8hiv/aids10.4
9diabetes mellitus10.3
10acute leukemia10.3
11pharyngitis10.2
12dermatitis10.2
13stomatitis10.2
14hiv-110.2
15tonsillitis10.1DEFB4A, DEFB1
16duodenal ulcer10.1DEFB4A, DEFB1
17periodontal disease10.1MPO, LTF
18otitis media10.1DEFB1, LTF
19amyloid tumor10.1LTF, B2M
20churg-strauss syndrome10.1MPO, LTF
21cholesteatoma10.1DEFB1, DEFB4A
22polyarteritis nodosa10.1LTF, MPO
23gastritis10.1DEFB4A, DEFB1, LTF
24bacterial vaginosis10.1SLPI, LTF
25chediak-higashi syndrome10.0MPO, SH2D1A
26secondary hyperparathyroidism of renal origin10.0SLPI, B2M
27hypersensitivity reaction type ii disease10.0B2M, MPO, LTF
28herpes zoster10.0TMPO, CD9
29crohn's disease10.0
30diabetic ketoacidosis10.0
31oral squamous cell carcinoma10.0
32chikungunya10.0
33acute myeloid leukemia10.0
34cryptococcosis10.0
35tinea pedis10.0
36median rhomboid glossitis10.0
37esophageal candidiasis10.0
38cheilitis10.0
39diarrhea10.0
40esophagitis10.0
41histoplasmosis10.0
42lymphadenitis10.0
43meningitis10.0
44multiple myeloma10.0
45myasthenia gravis10.0
46myeloid leukemia10.0
47myeloma10.0
48thymoma10.0
49tongue cancer10.0
50uveitis10.0

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Symptoms for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Oral Candidiasis

Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Search CenterWatch for Oral Candidiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Oral Candidiasis:

34
Tongue, Colon, Kidney, Liver, Myeloid, T cells

Animal Models for Oral Candidiasis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Oral Candidiasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.8B2M, SH2D1A, APCS, MPO, SKAP2, CD9
2MP:00053976.4LTF, B2M, SH2D1A, APCS, MPO, TMPO

Publications for Oral Candidiasis

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53PubMed
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Articles related to Oral Candidiasis:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults. (23123068)
2013
2
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
3
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. (21859389)
2012
4
Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis. (21788726)
2011
5
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (20614427)
2010
6
Oral candidiasis of HIV-infected children undergoing sequential HIV therapies. (18651304)
2009
7
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
8
Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. (19089255)
2008
9
Microbiological and immunological features of oral candidiasis. (17704633)
2007
10
Oral candidiasis infections with limited clinical findings. (16884077)
2006
11
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
12
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
13
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. (15599347)
2005
14
Interventions for preventing oral candidiasis for patients with cancer receiving treatment. (15495065)
2004
15
Self-care intervention to reduce oral candidiasis recurrences in HIV-seropositive persons: a pilot study. (15151689)
2004
16
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. (14731170)
2004
17
Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. (12839324)
2003
18
Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. (12506950)
2002
19
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)
2002
20
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. (11805777)
2002
21
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (11869615)
2002
22
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: cochrane systematic review. (12214838)
2002
23
Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. (12058869)
2002
24
CD4 lymphocyte percentage vs CD4 lymphocyte count as an immunological marker of oral candidiasis in HIV-infected patients. (11495199)
2001
25
Increased serum and salivary immunoglobulins against Candida albicans in HIV-infected patients with oral candidiasis. (11506465)
2001
26
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
27
The influence of different risk behaviors in the appearance of oral candidiasis in aids patients. (11507541)
2000
28
Oral candidiasis, switching and antifungal resistance. (12608245)
2000
29
Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis. (10992484)
2000
30
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
31
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
32
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. (9143608)
1997
33
Ketoconazole resistant oral candidiasis in HIV-infected patients. (9247940)
1997
34
The successful treatment of oral candidiasis (thrush) in a pediatric patient using itraconazole. (9192426)
1997
35
Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient. (8735114)
1996
36
Omeprazole as a cause of oral candidiasis. (7632080)
1995
37
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
38
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. (8027327)
1994
39
Host factors associated with HIV-related oral candidiasis. A review. (1532236)
1992
40
Treatment of refractory oral candidiasis with fluconazole. A case report. (1994321)
1991
41
Acute oral candidiasis during febrile episodes in immunocompromised patients with haematologic malignancies. (2196672)
1990
42
Oral candidiasis: an old disease of growing concern. (2132223)
1990
43
Oral candidiasis in terminal illness. (3679809)
1987
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
46
Clinical diagnosis and treatment of oral candidiasis. (3858462)
1985
47
Natamycin and nystatin for treatment of oral candidiasis during and after radiotherapy. (6607989)
1984
48
Prophylaxis of oral candidiasis with clotrimazole troches. (6365008)
1984
49
A new approach to the use of antifungal agents in infants with persistent oral candidiasis. (7452393)
1981
50
Oral candidiasis. (701536)
1978

Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Candidiasis

Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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Sources:
51PathCards, 5Cell Signaling Technology, 56Reactome, 31KEGG
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Compounds for genes affiliated with Oral Candidiasis

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Oral Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4610.3LTF, B2M
2iohexol4610.2B2M, LTF
3naphthol as-d chloroacetate4610.2LTF, MPO
4hypothiocyanite46 2511.1LTF, MPO
5pmma4610.1LTF, HTN3, B2M
6iopentol4610.1B2M, SLPI
7fluconazole46 1211.1HTN3, LTF, SH2D1A
8thiocyanate46 2511.1MPO, LTF
9ampicillin46 1211.0LTF, MPO
10sodium azide4610.0HTN3, MPO
11hypoxanthine46 25 1211.9LTF, MPO, B2M
12vitamin b12469.9B2M, MPO, LTF
13chloramine t469.8SLPI, MPO
14neopterin469.8B2M, LTF, CD9
15succinate469.8B2M, LTF, SLPI
16whey469.7SLPI, LTF
17methacholine46 52 1211.7MPO, SLPI, LTF
18dextran sulfate469.7LTF, MPO, CD9
19pentoxifylline46 1210.7CD9, LTF, MPO
20zidovudine46 52 1211.6TMPO, CD9, B2M
21leukotriene b446 62 2511.6LTF, MPO, SLPI
22nacl469.6LTF, SLPI, DEFB1, DEFB4A
23hbd2469.6DEFB4A, DEFB1, DEFB103B
24heparan sulfate46 2510.5B2M, DEFB1, LTF
25indomethacin46 30 62 1212.5B2M, MPO, LTF, TMPO
26cyclophosphamide46 52 1211.5B2M, MPO, LTF
27hyaluronic acid46 2510.5LTF, B2M, SLPI
28mannose469.5LTF, DEFB4A, CD9
29uric acid46 2510.5B2M, SLPI, CD9
30histamine46 30 2511.4LTF, MPO, SLPI, DEFB4A
31cyclosporin a46 30 6211.3TMPO, B2M, LTF, SLPI
32indinavir46 52 1211.3SLPI, SKAP2, APCS
33rantes469.3SLPI, CD9, DEFB1, DEFB4A
34genistein46 30 62 3 25 1214.2B2M, SLPI, CD9, DEFB4A
35paraffin469.2DEFB4A, B2M, MPO, CD9, LTF
36endotoxin469.1DEFB4A, SLPI, LTF
37ascorbic acid46 2510.1LTF, CD9, MPO, SLPI
38creatinine469.1B2M, MPO, SLPI, LTF
39pge2469.0MPO, LTF, B2M, SLPI, TMPO
40aspartate469.0LTF, SKAP2, TMPO, B2M, SLPI
41heparin46 30 25 1211.9LTF, DEFB4A, MPO, CD9, SLPI
42iron46 259.9SLPI, CD9, B2M, MPO, LTF
43saquinavir46 129.8APCS, SKAP2, CD9, SLPI
44glucose468.7SLPI, DEFB1, B2M, TMPO, CD9
45dexamethasone46 52 30 1211.7DEFB103B, DEFB1, LTF, SLPI, DEFB4A
46tyrosine468.3SH2D1A, TMPO, SKAP2, CD9, DEFB4A, SLPI
47retinoic acid46 259.0B2M, MUC7, DEFB1, SLPI, LTF, DEFB4A
48cysteine467.7CD9, HTN3, MUC7, B2M, DEFB103B, DEFB4A
49anti-fungal467.4MUC7, SKAP2, HTN3, DEFB4A, APCS, LTF
50calcium46 52 25 129.6DEFB4A, SLPI, CD9, HTN3, TMPO, MPO

GO Terms for genes affiliated with Oral Candidiasis

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17Gene Ontology
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Cellular components related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3DEFB4A, DEFB1, MUC7
2extracellular regionGO:0055768.5LTF, HTN3, APCS, B2M, DEFB1, DEFB4A
3extracellular vesicular exosomeGO:0700627.4LTF, SLPI, CD9, MUC7, MPO, APCS

Biological processes related to Oral Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retina homeostasisGO:0018959.9LTF, B2M
2defense response to bacteriumGO:0427429.6HTN3, DEFB1, DEFB4A
3defense response to fungusGO:0508329.5HTN3, MPO

Products for genes affiliated with Oral Candidiasis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Oral Candidiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet