MCID: ORL005
MIFTS: 49

Oral Candidiasis malady

Oral diseases category

Summaries for Oral Candidiasis

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CDC:3 Candidiasis that develops in the mouth or throat is called "thrush" or oropharyngeal candidiasis. The most common symptom of oral thrush is white patches or plaques on the tongue and other oral mucous membranes. This infection is uncommon among healthy adults.

MalaCards based summary: Oral Candidiasis, also known as thrush, is related to candidiasis and acquired immunodeficiency syndrome. An important gene associated with Oral Candidiasis is DEFB4A (defensin, beta 4A), and among its related pathways are Lymphocyte Signaling and Defensins. The drugs flucytosine and itraconazole and the compounds cellulose triacetate and iohexol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A candidiasis that involves fungal infection of the mucous membrane of the mouth by candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

Wikipedia:63 Oral candidiasis (also known as oral candidosis, oral thrush,oropharyngeal candidiasis,... more...

Aliases & Classifications for Oral Candidiasis

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 3CDC, 38NCIt, 55SNOMED-CT, 33MeSH, 27ICD9CM
See all sources

Oral Candidiasis, Aliases & Descriptions:

Name: Oral Candidiasis 9 43 60
Thrush 9 3
Candidiasis of Mouth 9
Oral Moniliasis 9
 
Equine Thrush 60
Thrush, Oral 9
Candidiasis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology9 DOID:14262
NCIt38 C28137
MeSH33 D002180
ICD9CM27 112.0

Related Diseases for Oral Candidiasis

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Diseases related to Oral Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.8DEFB4A, SH2D1A, APCS, HTN3, SKAP2, LTF
2acquired immunodeficiency syndrome31.1B2M
3asthma30.2DEFB4A, DEFB1, MPO
4pneumonia29.9SLPI, CD9, MPO, DEFB1, DEFB4A
5psoriasis29.8LTF, SLPI, DEFB4A
6hiv-129.6B2M, APCS, TMPO, HTN3, CD9, SLPI
7leukemia29.5SLPI, CD9, TMPO, MPO, SH2D1A, B2M
8leukoplakia10.6
9oral hairy leukoplakia10.5
10tonsillitis10.3DEFB4A, DEFB1
11acne10.3DEFB1, DEFB4A
12duodenal ulcer10.3DEFB4A, DEFB1
13periodontal disease10.3MPO, LTF
14acute leukemia10.3
15otitis media10.3DEFB1, LTF
16churg-strauss syndrome10.3LTF, MPO
17polyarteritis nodosa10.3LTF, MPO
18cholesteatoma10.3DEFB1, DEFB4A
19gastritis10.2DEFB4A, DEFB1, LTF
20bacterial vaginosis10.2SLPI, LTF
21pharyngitis10.2
22dermatitis10.2
23stomatitis10.2
24chediak-higashi syndrome10.2MPO, SH2D1A
25secondary hyperparathyroidism of renal origin10.2B2M, SLPI
26hypersensitivity reaction type ii disease10.1LTF, MPO, B2M
27herpes zoster10.1TMPO, CD9
28bronchiectasis10.1SLPI, MPO
29vasculitis10.1LTF, MPO, SH2D1A
30systemic lupus erythematosus10.0
31myeloperoxidase deficiency10.0
32severe combined immunodeficiency, x-linked10.0
33candidiasis, familial, 2, autosomal recessive10.0
34multiple myeloma10.0
35immunodeficiency 32b, monocyte and dendritic cell deficiency, autosomal recessive10.0
36crohn's disease10.0
37myasthenia gravis10.0
38diabetic ketoacidosis10.0
39oral squamous cell carcinoma10.0
40chikungunya10.0
41angular cheilitis10.0
42tinea pedis10.0
43cryptococcosis10.0
44median rhomboid glossitis10.0
45esophageal candidiasis10.0
46cheilitis10.0
47diarrhea10.0
48esophagitis10.0
49histoplasmosis10.0
50lupus erythematosus10.0

Graphical network of the top 20 diseases related to Oral Candidiasis:



Diseases related to oral candidiasis

Symptoms for Oral Candidiasis

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Drugs & Therapeutics for Oral Candidiasis

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Drug clinical trials:

Search ClinicalTrials for Oral Candidiasis

Search NIH Clinical Center for Oral Candidiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Oral Candidiasis

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Anatomical Context for Oral Candidiasis

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MalaCards organs/tissues related to Oral Candidiasis:

31
Tongue, Colon, Kidney, Liver, Myeloid, T cells, Neutrophil

Animal Models for Oral Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Oral Candidiasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.8DEFB1, B2M, SH2D1A, APCS, MPO, SKAP2
2MP:00053976.4B2M, SH2D1A, APCS, MPO, TMPO, SKAP2

Publications for Oral Candidiasis

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Articles related to Oral Candidiasis:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels. (25682023)
2015
2
Prevalence of oral candidiasis in HIV/AIDS children in highly active antiretroviral therapy-era. A literature analysis. (25156369)
2014
3
Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasis. (24752272)
2014
4
Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults. (23123068)
2013
5
Clinical and microbiological diagnosis of oral candidiasis. (24455095)
2013
6
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
7
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. (21859389)
2012
8
Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis. (21788726)
2011
9
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (20614427)
2010
10
Oral candidiasis of HIV-infected children undergoing sequential HIV therapies. (18651304)
2009
11
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
12
Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. (19089255)
2008
13
Microbiological and immunological features of oral candidiasis. (17704633)
2007
14
Oral candidiasis infections with limited clinical findings. (16884077)
2006
15
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
16
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
17
Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. (15599347)
2005
18
Interventions for preventing oral candidiasis for patients with cancer receiving treatment. (15495065)
2004
19
Self-care intervention to reduce oral candidiasis recurrences in HIV-seropositive persons: a pilot study. (15151689)
2004
20
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. (14731170)
2004
21
Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. (12839324)
2003
22
Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. (12506950)
2002
23
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)
2002
24
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. (11805777)
2002
25
Interventions for treating oral candidiasis for patients with cancer receiving treatment. (11869615)
2002
26
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: cochrane systematic review. (12214838)
2002
27
CD4 lymphocyte percentage vs CD4 lymphocyte count as an immunological marker of oral candidiasis in HIV-infected patients. (11495199)
2001
28
Increased serum and salivary immunoglobulins against Candida albicans in HIV-infected patients with oral candidiasis. (11506465)
2001
29
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
30
The influence of different risk behaviors in the appearance of oral candidiasis in aids patients. (11507541)
2000
31
Oral candidiasis, switching and antifungal resistance. (12608245)
2000
32
Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis. (10992484)
2000
33
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
34
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
35
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. (9143608)
1997
36
Ketoconazole resistant oral candidiasis in HIV-infected patients. (9247940)
1997
37
Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient. (8735114)
1996
38
Omeprazole as a cause of oral candidiasis. (7632080)
1995
39
Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. (8011239)
1994
40
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. (8027327)
1994
41
Host factors associated with HIV-related oral candidiasis. A review. (1532236)
1992
42
Acute oral candidiasis during febrile episodes in immunocompromised patients with haematologic malignancies. (2196672)
1990
43
Oral candidiasis in terminal illness. (3679809)
1987
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
46
Clinical diagnosis and treatment of oral candidiasis. (3858462)
1985
47
Natamycin and nystatin for treatment of oral candidiasis during and after radiotherapy. (6607989)
1984
48
Prophylaxis of oral candidiasis with clotrimazole troches. (6365008)
1984
49
A new approach to the use of antifungal agents in infants with persistent oral candidiasis. (7452393)
1981
50
Oral candidiasis. (701536)
1978

Variations for Oral Candidiasis

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Expression for genes affiliated with Oral Candidiasis

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Search GEO for disease gene expression data for Oral Candidiasis.

Pathways for genes affiliated with Oral Candidiasis

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Compounds for genes affiliated with Oral Candidiasis

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Compounds related to Oral Candidiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cellulose triacetate4310.3LTF, B2M
2iohexol4310.2B2M, LTF
3naphthol as-d chloroacetate4310.2LTF, MPO
4hypothiocyanite43 2411.1LTF, MPO
5pmma4310.1LTF, HTN3, B2M
6iopentol4310.1B2M, SLPI
7fluconazole43 1211.1HTN3, LTF, SH2D1A
8thiocyanate43 2411.1MPO, LTF
9ampicillin43 1211.0LTF, MPO
10sodium azide4310.0HTN3, MPO
11hypoxanthine43 24 1211.9LTF, MPO, B2M
12vitamin b12439.9B2M, MPO, LTF
13chloramine t439.8SLPI, MPO
14neopterin439.8B2M, LTF, CD9
15succinate439.8B2M, LTF, SLPI
16whey439.7SLPI, LTF
17methacholine43 49 1211.7MPO, SLPI, LTF
18dextran sulfate439.7LTF, MPO, CD9
19pentoxifylline43 1210.7CD9, LTF, MPO
20zidovudine43 49 1211.6TMPO, CD9, B2M
21leukotriene b443 59 2411.6LTF, MPO, SLPI
22nacl439.6LTF, SLPI, DEFB1, DEFB4A
23hbd2439.6DEFB4A, DEFB1, DEFB103B
24heparan sulfate43 2410.5B2M, DEFB1, LTF
25indomethacin43 28 59 1212.5B2M, MPO, LTF, TMPO
26cyclophosphamide43 49 1211.5B2M, MPO, LTF
27hyaluronic acid43 2410.5LTF, B2M, SLPI
28mannose439.5LTF, DEFB4A, CD9
29uric acid43 2410.5B2M, SLPI, CD9
30histamine43 28 2411.4LTF, MPO, SLPI, DEFB4A
31cyclosporin a43 28 5911.3TMPO, B2M, LTF, SLPI
32indinavir43 49 1211.3SLPI, SKAP2, APCS
33rantes439.3SLPI, CD9, DEFB1, DEFB4A
34genistein43 28 59 2 24 1214.2B2M, SLPI, CD9, DEFB4A
35paraffin439.2DEFB4A, B2M, MPO, CD9, LTF
36endotoxin439.1DEFB4A, SLPI, LTF
37ascorbic acid43 2410.1LTF, CD9, MPO, SLPI
38creatinine439.1B2M, MPO, SLPI, LTF
39pge2439.0MPO, LTF, B2M, SLPI, TMPO
40aspartate439.0LTF, SKAP2, TMPO, B2M, SLPI
41heparin43 28 24 1211.9LTF, DEFB4A, MPO, CD9, SLPI
42iron43 249.9SLPI, CD9, B2M, MPO, LTF
43saquinavir43 129.8APCS, SKAP2, CD9, SLPI
44glucose438.7SLPI, DEFB1, B2M, TMPO, CD9
45dexamethasone43 49 28 1211.7DEFB103B, DEFB1, LTF, SLPI, DEFB4A
46tyrosine438.3SH2D1A, TMPO, SKAP2, CD9, DEFB4A, SLPI
47retinoic acid43 249.0B2M, MUC7, DEFB1, SLPI, LTF, DEFB4A
48cysteine437.7CD9, HTN3, MUC7, B2M, DEFB103B, DEFB4A
49anti-fungal437.4MUC7, SKAP2, HTN3, DEFB4A, APCS, LTF
50calcium43 49 24 129.6DEFB4A, SLPI, CD9, HTN3, TMPO, MPO

GO Terms for genes affiliated with Oral Candidiasis

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Cellular components related to Oral Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.3DEFB4A, DEFB1, MUC7
2extracellular regionGO:00055768.5LTF, HTN3, APCS, B2M, DEFB1, DEFB4A
3extracellular vesicular exosomeGO:00700627.4LTF, SLPI, CD9, MUC7, MPO, APCS

Biological processes related to Oral Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retina homeostasisGO:00018959.9LTF, B2M
2defense response to bacteriumGO:00427429.6HTN3, DEFB1, DEFB4A
3defense response to fungusGO:00508329.5HTN3, MPO

Products for genes affiliated with Oral Candidiasis

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Sources for Oral Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet