MCID: ORL007
MIFTS: 49

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories

Summaries for Oral Cavity Cancer

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Disease Ontology:10 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards based summary: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lip and oral cavity cancer and hepatitis. An important gene associated with Oral Cavity Cancer is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are Apoptosis and survival Caspase cascade and Lymphocyte Signaling. The compounds sulindac sulfide and sulindac have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Oral Cavity Cancer

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Oral Cavity Cancer, Aliases & Descriptions:

Name: Oral Cavity Cancer 10 12
Malignant Neoplasm of Anterior Portion of Floor of Mouth 10 62
Malignant Neoplasm of Lateral Portion of Floor of Mouth 10 62
Malignant Neoplasm of Lateral Floor of Mouth 10 62
Malignant Tumor of Anterior Floor of Mouth 10 62
 
Malignant Tumor of the Floor of the Mouth 10 62
Malignant Tumor of Lateral Floor of Mouth 10 62
Malignant Neoplasm of Floor of Mouth 10 62
Malignant Neoplasm of Mouth 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology10 DOID:8618
ICD9CM29 144, 144.9
NCIt40 C9318
ICD1027 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Symptoms for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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MalaCards organs/tissues related to Oral Cavity Cancer:

33
Lymph node, Neutrophil, Lung, Testes, Bone, Salivary gland, Monocytes, Nk cells, B cells

FMA organs/tissues related to Oral Cavity Cancer:

16
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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MGI Mouse Phenotypes related to Oral Cavity Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1FADD, TNFRSF10B, GPX1, TLR6
2MP:00053977.2FADD, TNFRSF10B, GPX1, TLR6, GDF15

Publications for Oral Cavity Cancer

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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Use of customized intraoral mold high-dose-rate brachytherapy in the treatment of oral cavity cancer in an elderly patient. (25413412)
2015
2
Time-Dependent Pretreatment with Bevacuzimab Increases Tumor Specific Uptake of Cetuximab in Preclinical Oral Cavity Cancer Studies. (25719497)
2015
3
Changes and predictors of radiation-induced oral mucositis in patients with oral cavity cancer during active treatment. (25586214)
2015
4
Sentinel node biopsy for early-stage oral cavity cancer: the VU University Medical Center experience. (24677355)
2014
5
Prognostic factors in advanced pharyngeal and oral cavity cancer; significance of multimodality imaging in terms of 7th edition of TNM. (25608735)
2014
6
Lymph node ratio as a valuable additional predictor of outcome in selected patients with oral cavity cancer. (24842444)
2014
7
Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. (24706327)
2014
8
Trends in the incidence of and survival rates for oral cavity cancer in the Korean population. (24735459)
2014
9
Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases. (25257901)
2014
10
Clinical outcome of high-dose-rate interstitial brachytherapy in patients with oral cavity cancer. (25568852)
2014
11
Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. (24064974)
2013
12
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer? (23346903)
2013
13
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. (23733351)
2013
14
Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy. (22730021)
2013
15
Accuracy of 3 Month Posttherapy FDG PET/CT in Resected Oral Cavity Cancer Patients Who Received Adjuvant Radiation. (24674525)
2013
16
Body mass index, body mass change, and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23677332)
2013
17
Assessment of quality of life of patients with oral cavity cancer who have had defects reconstructed with free anterolateral thigh perforator flaps. (23107622)
2013
18
Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients? (23893514)
2013
19
Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction. (22565542)
2012
20
Association of HPV infections with second primary tumors in early-staged oral cavity cancer. (22747969)
2012
21
The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. (21500194)
2012
22
Identification of a high-risk subgroup of patients with resected pT3 oral cavity cancer in need of postoperative adjuvant therapy. (21360248)
2011
23
The roles of hope and optimism on posttraumatic growth in oral cavity cancer patients. (21183398)
2011
24
Mortality of oral cavity cancer in Iran. (22320989)
2011
25
Oral cavity cancer risk in relation to tobacco chewing and bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. (21129124)
2011
26
Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. (21804026)
2011
27
Comparison between free flap and pectoralis major pedicled flap for reconstruction in oral cavity cancer patients--a quality of life analysis. (21498107)
2011
28
Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. (20308004)
2010
29
Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. (19585476)
2010
30
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. (20336792)
2010
31
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. (19259098)
2009
32
Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. (18805047)
2009
33
Analysis of risk factors of predictive local tumor control in oral cavity cancer. (18165878)
2008
34
Oral cavity cancer. (17893592)
2007
35
Using stereolithographic models to plan mandibular reconstruction for advanced oral cavity cancer. (17415150)
2007
36
Long-term survival in locally advanced oral cavity cancer: an analysis of patients treated with neoadjuvant cisplatin-based chemotherapy followed by surgery. (15880411)
2005
37
Postoperative radiotherapy after titanium plate mandibular reconstruction for oral cavity cancer. (16199984)
2005
38
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. (15598591)
2005
39
Salivary epidermal growth factor in oral cavity cancer. (15598585)
2005
40
Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. (16118155)
2005
41
Oral cavity cancer. (16361136)
2005
42
Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. (15792610)
2005
43
Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. (15342664)
2004
44
Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. (12915878)
2003
45
Distant metastases from lip and oral cavity cancer. (11408816)
2001
46
Soluble IL-6 receptor release by PMNs and PBMC in patients with oral cavity cancer. (9581469)
1997
47
Oral cavity cancer: 234 patients treated with radiotherapy alone with curative intent. (3076686)
1988
48
Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. (3829319)
1987
49
Functional analysis of treatment of oral cavity cancer. (3741662)
1986
50
New test series for the functional evaluation of oral cavity cancer. (4066369)
1985

Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.6FADD, TNFRSF6B
29.4GPX1, GDF15
39.4TLR6, FADD
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.2FADD, TNFRSF10B
5
Show member pathways
9.2FADD, TNFRSF10B
69.2TNFRSF10B, FADD
7
Show member pathways
TRAIL signaling pathway38
9.2FADD, TNFRSF10B
8
Show member pathways
9.2TNFRSF10B, FADD
99.0TLR6, TNFRSF10B
10
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.8FADD, TNFRSF10B, TNFRSF6B
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.8TNFRSF10B, FADD, TNFRSF6B
12
Show member pathways
8.8FADD, TNFRSF6B, TNFRSF10B
138.6GDF15, TNFRSF10B, GPX1
14
Show member pathways
8.6FADD, TLR6, TNFRSF10B
15
Show member pathways
8.6FADD, TLR6, TNFRSF10B
168.3TNFRSF10B, GDF15, TNFRSF6B, FADD
17
Show member pathways
8.2TNFRSF10B, TNFRSF6B, FADD, TLR6

Compounds for genes affiliated with Oral Cavity Cancer

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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulindac sulfide459.3TNFRSF10B, GDF15
2sulindac45 1310.1TNFRSF10B, GDF15
3sp 60012545 6110.1FADD, TNFRSF10B
4ceramide458.9FADD, TNFRSF10B, GPX1
5phosphatidylinositol458.8GDF15, TNFRSF6B, FADD
6doxorubicin45 51 1310.8GPX1, TNFRSF10B, FADD
7oxygen45 269.7FADD, TNFRSF10B, GPX1
8lipid458.1TLR6, GPX1, TNFRSF10B, FADD

GO Terms for genes affiliated with Oral Cavity Cancer

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Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.4TNFRSF10B, FADD
2extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.3TNFRSF10B, FADD
3cellular response to mechanical stimulusGO:00712609.3TNFRSF10B, FADD
4toll-like receptor 4 signaling pathwayGO:00341429.3TLR6, FADD
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.3TNFRSF10B, FADD
6activation of NF-kappaB-inducing kinase activityGO:00072509.2TLR6, TNFRSF10B
7apoptotic signaling pathwayGO:00971909.2FADD, TNFRSF10B
8toll-like receptor signaling pathwayGO:00022249.1TLR6, FADD
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.8TLR6, TNFRSF10B, FADD
10apoptotic processGO:00069158.8TNFRSF6B, FADD, TNFRSF10B

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00048728.6TNFRSF6B, TNFRSF10B, TLR6

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
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  • Kits and Assays

Sources for Oral Cavity Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet