MCID: ORL007
MIFTS: 61

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories

Summaries for Oral Cavity Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lung cancer and hepatitis c. An important gene associated with Oral Cavity Cancer is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are ethanol degradation II and Caffeine Pathway, Pharmacokinetics. The compounds estrogen and nadph have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and lung, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Oral Cavity Cancer

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cavity cancer 8 10
malignant neoplasm of anterior portion of floor of mouth 8
malignant neoplasm of lateral portion of floor of mouth 8
malignant neoplasm of other sites of floor of mouth 8
malignant neoplasm of lateral floor of mouth 8
malignant tumor of anterior floor of mouth 8
malignant tumor of the floor of the mouth 8
malignant neoplasm of floor of mouth, nos 8
malignant tumor of lateral floor of mouth 8
malignant neoplasm of floor of mouth nos 8
malignant neoplasm of floor of mouth 8
malignant tumor of floor of mouth 8
malignant neoplasm of mouth 60


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Disease Ontology8 DOID:8618
ICD9CM27 144, 144.9
NCIt39 C9318
ICD1025 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Oral Cavity Cancer family:

Oral Cavity Carcinoma in Situ

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.4CASP8, SOD2, CYP1A1, CYP2E1, GDF15, GSTM1
2hepatitis c30.1SOD2, CYP1A1, CYP2E1, IL18, GSTM1
3hepatitis30.1CASP8, SOD2, CYP2E1, NAT2, IL18, CP
4lymph node cancer10.5
5mandibular cancer10.3
6oropharynx cancer10.3
7lip and oral cavity cancer10.3
8lip cancer10.2
9hepatitis a10.1
10hypopharynx cancer10.1
11salivary gland cancer10.1
12age related macular degeneration10.0HEPH
13prostatitis10.0GDF15
14esophagitis10.0SOD2
15dermatitis10.0IL18
16pneumoconiosis10.0CP
17acute myocardial infarction10.0GSTM1
18fatty liver disease10.0CYP2E1
19graves' disease10.0MPO
20iron deficiency anemia10.0HEPH
21cholestasis10.0CP
22neuropathy10.0SOD2
23esophageal cancer10.0ALDH2, CYP2E1
24meningioma10.0GSTT1
25myocardial infarction10.0ALDH2, GSTT1
26primary open angle glaucoma10.0GSTM1
27schistosomiasis10.0GSTM1
28schizophrenia10.0GPX1, CP
29lupus erythematosus10.0NAT2, IL18
30psoriasis10.0IL18, NAT2
31aceruloplasminemia10.0CP, HEPH
32osteoarthritis10.0IL18, TNFRSF10B
33thyroid cancer10.0GSTT1, GSTM1
34motor neuron disease10.0SOD2, GSTT1
35medulloblastoma10.0TNFRSF10B, CASP8
36hemochromatosis10.0CP, HEPH
37asbestosis10.0GSTT1, GSTM1
38periodontal disease10.0MPO
39toxic encephalopathy10.0GPX1, SOD2
40familial adenomatous polyposis10.0NAT2, TNFRSF10B
41malignant mesothelioma10.0SOD2, TNFRSF10B, NAT2
42hyperglycemia10.0GPX1, SOD2
43insulin resistance10.0IL18, CYP2E1
44myeloma10.0TNFRSF10B, CASP8, HSP90B1
45hypercholesterolemia10.0SOD2
46colon adenocarcinoma10.0TNFRSF6B, CASP8
47coronary heart disease10.0GDF15, IL18, GSTT1
48molluscum contagiosum10.0CASP8, IL18
49cataract10.0NAT2, GPX1, GSTT1
50down syndrome10.0SOD2, GDF15, GPX1

Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Clinical Features for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Oral Cavity Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Search CenterWatch for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Oral Cavity Cancer:

32
Lymph node, Lung, Testes, Salivary gland, B cells, Monocytes, Nk cells, Tongue, Bone

FMA organs/tissues related to Oral Cavity Cancer:

14
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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Sources:
36MGI
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Publications for Oral Cavity Cancer

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Sources:
50PubMed
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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. (24064974)
2013
2
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer? (23346903)
2013
3
Tea and coffee consumption and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23453554)
2013
4
Survival of patients with oral cavity cancer in Germany. (23349710)
2013
5
Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer. (22907805)
2013
6
Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case-control study, the ICARE study. (22976386)
2013
7
The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. (21500194)
2012
8
Podoplanin in the development and progression of oral cavity cancer: a preliminary study. (23285404)
2012
9
High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer. (22160650)
2012
10
The association between surgical site infection and previous operation in oral cavity cancer patients. (21779839)
2012
11
The roles of hope and optimism on posttraumatic growth in oral cavity cancer patients. (21183398)
2011
12
Oral cavity cancer risk in relation to tobacco chewing and bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. (21129124)
2011
13
Computed tomography perfusion examination is helpful in evaluating the extent of oropharyngeal and oral cavity cancer. (22802811)
2011
14
Psychometric testing of the Chinese-version cancer needs questionnaire short form head and neck cancer-specific version in oral cavity cancer patients. (20422230)
2011
15
GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapy. (21992474)
2011
16
Promoter hypermethylation and expression profile of MGMT and CDH1 genes in oral cavity cancer. (20674887)
2010
17
Oral cavity cancer in developed and in developing countries: population-based incidence. (19644932)
2010
18
Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins. (20005769)
2010
19
Functional p53 status as a biomarker for chemotherapy response in oral-cavity cancer. (20048171)
2010
20
Outcome analysis of patients with pN2 oral cavity cancer. (20135357)
2010
21
The development of quality of care measures for oral cavity cancer. (18559740)
2008
22
Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer. (18797097)
2008
23
Intra-arterial chemoradiation for T3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. (18194553)
2008
24
Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in 134 cases. (18283309)
2008
25
T4b oral cavity cancer below the mandibular notch is resectable with a favorable outcome. (16996777)
2007
26
STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy. (17559122)
2007
27
Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer. (17443722)
2007
28
Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity? (17236926)
2007
29
Assessment of the quality of life in patients with oral cavity and jaw cancer in three regions of Bulgaria. (17918295)
2007
30
Tracheal incision for elective tracheotomy in oral cavity cancer. (17079186)
2007
31
Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. (16118155)
2005
32
Oral cavity cancer. (16361136)
2005
33
Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. (15878520)
2005
34
Epidemiology of oral cavity cancer in taiwan with emphasis on the role of betel nut chewing. (16254455)
2005
35
Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. (15342664)
2004
36
Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity. (11745290)
2001
37
Effects of chemotherapy on invasion and metastasis of oral cavity cancer in mice. (11505487)
2001
38
Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. (10753201)
2000
39
Cost-identification analysis in oral cavity cancer management. (9482555)
1998
40
Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. (9390539)
1997
41
Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. (11173639)
1997
42
Aesthetic and functional reconstruction with the trapezius osseomyocutaneous flap and dental implants in oral cavity cancer patients. (9032599)
1996
43
Neo-adjuvant organ-preserving chemotherapy in the management of locally advanced oral cavity and oropharynx cancer. (21541554)
1996
44
Prognostic significance of p53 protein accumulation in early stage T1 oral cavity cancer. (7950844)
1994
45
Management of early oral cavity cancer. Experience of Centre Oscar Lambret. (7920170)
1994
46
Re: Oral cavity cancer in non-users of tobacco. (8360936)
1993
47
Mouthcare in oral cavity cancer. (2107430)
1990
48
Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. (3829319)
1987
49
New test series for the functional evaluation of oral cavity cancer. (4066369)
1985
50
Acute vitamin B1 deficiency (wernicke's encephalopathy) in connection with radiotherapy for oral cavity cancer. (7309677)
1981

Genetic Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP2E1, ALDH2
2
Hide members
10.2NAT2, CYP2E1
310.1GSTT1, GSTM1
4
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10.1CYP1A1, CYP2E1, GPX1
5
Hide members
10.0FADD, TNFRSF10B, CASP8
6
Hide members
10.0FADD, TNFRSF10B, CASP8
7
Hide members
10.0FADD, TNFRSF10B, CASP8
810.0CASP8, TNFRSF10B, FADD
9
Apoptosis and survival Apoptotic TNF-family pathways
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10.0FADD, TNFRSF10B, CASP8
10
Hide members
10.0CYP1A1, CYP2E1, ALDH2
11
Retinol metabolism
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10.0CYP1A1, CYP2E1, ALDH2
12
Hide members
10.0ALDH2, CYP2E1, CYP1A1
13
Acetaminophen metabolism
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10.0NAT2, CYP2E1, CYP1A1
14
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10.0NAT2, CYP2E1, CYP1A1
1510.0SOD2, CYP1A1, GPX1
16
Glutathione metabolism
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10.0GPX1, GSTM1, GSTT1
1710.0TAX1BP1, TNFRSF10B, TLR6
18
Hide members
10.0TLR6, CASP8, HSP90B1
1910.0SOD2, MPO, GPX1
20
Apoptosis and survival Caspase cascade
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9.9FADD, TNFRSF6B, CASP8
21
Hide members
9.9IL18, CASP8, HSP90B1
22
Hide members
9.9FADD, TNFRSF10B, TLR6, CASP8
239.9MPO, GSTM1, GSTT1
24
Hide members
9.9TLR6, TNFRSF6B, TNFRSF10B, FADD
259.9CASP8, TLR6, FADD, IL18
26
Hide members
9.8HSP90B1, CASP8, TLR6, FADD
27
Hide members
9.8CASP8, TNFRSF6B, TNFRSF10B, FADD
28
Hide members
9.8FADD, TNFRSF10B, TNFRSF6B, CASP8
29
Naphthalene metabolism
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9.8CYP1A1, CYP2E1, GSTM1, GSTT1
30
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9.7CASP8, SOD2, FADD, CYP2E1, GPX1
31
Hide members
9.7CYP1A1, CYP2E1, NAT2, GSTM1, GSTT1
32
Hide members
9.5CYP1A1, CYP2E1, NAT2, ALDH2, GSTM1, GSTT1
339.4TAX1BP1, GDF15, FADD, TNFRSF10B, TNFRSF6B, CASP8
34
Hide members
9.4HSP90B1, CASP8, TLR6, FADD, IL18, TAX1BP1

Compounds for genes affiliated with Oral Cavity Cancer

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GDF15
2nadph44 2411.4SOD2, GPX1
3indomethacin44 59 28 1113.3GDF15
4drugs for treatment of tuberculosis4910.3NAT2, GSTT1, GSTM1
5trans,trans-muconic acid4410.3CYP2E1, GSTT1, GSTM1
6vinylchloride4410.2GSTT1, GSTM1, CYP2E1, ALDH2
7toluene4410.2CYP2E1, ALDH2, GSTM1, GSTT1
8styrene4410.2CYP2E1, NAT2, GSTT1, GSTM1
9s-phenylmercapturic acid4410.2GSTT1, GSTM1, CYP2E1
10debrisoquine4410.2CYP1A1, CYP2E1, NAT2, GSTM1
11trichloroethylene4410.2NAT2, GSTM1, GSTT1, CYP2E1
12buthionine sulfoximine4410.1SOD2, CYP2E1, GPX1, CASP8
13isoniazid49 44 1112.1CYP2E1, NAT2, GSTM1, GSTT1
148-oxo-dg4410.1GSTT1, GPX1, GSTM1, SOD2
15benzene4410.1GSTM1, GSTT1, CYP2E1, NAT2
161-hydroxypyrene4410.1GSTT1, GSTM1, NAT2, CYP2E1, CYP1A1
17acetone4410.1CYP1A1, CYP2E1, GSTM1, GSTT1
18rsai4410.1CYP2E1, NAT2, GSTT1, ALDH2, GSTM1
19mspi4410.1GSTM1, NAT2, CYP1A1, CYP2E1, GSTT1
20cyclophosphamide44 49 1112.1CYP2E1, CYP1A1, SOD2, GSTT1, GSTM1
21butadiene monoxide4410.0GSTT1, GSTM1, CYP2E1
22hydrocarbons4410.0GSTM1, GSTT1, NAT2, CYP1A1
23epoxide4410.0GSTT1, CYP2E1, GSTM1, NAT2, CYP1A1
24creatinine4410.0GSTM1, CP, ALDH2, CYP2E1, GSTT1
25butyrate4410.0SOD2
26vitamin a44 11 2412.0NAT2, CYP2E1, CYP1A1, CP, ALDH2, SOD2
27alpha tocopherol449.9ALDH2, SOD2, CYP1A1, GPX1, CP, GSTM1
284-hydroxynonenal44 2410.9GPX1, SOD2, GSTM1, ALDH2, CYP2E1, MPO
29valproic acid44 49 11 2412.9CYP2E1, CYP1A1, TNFRSF10B, CP, CASP8
30sulindac44 1110.9GDF15, CYP1A1, TNFRSF10B, CASP8
31malondialdehyde449.9MPO, GSTT1, GSTM1, CP, GPX1, SOD2
32gsts449.8ALDH2, CYP1A1, CYP2E1, NAT2, GPX1, GSTT1
33ethanol44 49 11 2412.7IL18, CYP2E1, CYP1A1, HSP90B1, ALDH2, GSTT1
34oxaliplatin44 49 1111.7GSTM1, MPO, TNFRSF10B, CASP8, GSTT1, CYP2E1
35folate449.7SOD2, NAT2, IL18, ALDH2, GSTM1, GSTT1
36n acetylcysteine449.7IL18, MPO, CASP8, TNFRSF10B, SOD2, GPX1
375fluorouracil449.7MPO, CASP8, SOD2, TNFRSF10B, FADD, IL18
38ascorbic acid44 2410.6CYP1A1, GSTT1, SOD2, GSTM1, MPO, CP
39doxorubicin44 49 1111.6CASP8, GSTT1, SOD2, GSTM1, GPX1, IL18
40oxygen44 2410.6HSP90B1, CASP8, TNFRSF10B, FADD, MPO, ALDH2
41betacarotene449.6ALDH2, CYP1A1, CP, GSTM1, CASP8, SOD2
42iron44 2410.5SOD2, GPX1, CP, HEPH, IL18, GDF15
43superoxide44 2410.4MPO, SOD2, CASP8, GPX1, ALDH2, CP
44lactate449.4IL18, SOD2, MPO, CYP1A1, CYP2E1, GSTM1
45cisplatin44 49 59 1112.4IL18, CASP8, GSTT1, CYP1A1, MPO, FADD
46retinoic acid44 2410.3IL18, ALDH2, CYP2E1, CP, CYP1A1, MPO
47cysteine449.3SOD2, FADD, CYP2E1, NAT2, IL18, CP
48h2o2449.2CASP8, MPO, SOD2, GPX1, CYP2E1, CYP1A1
49lipid449.2ALDH2, GSTT1, CP, FADD, TNFRSF10B, SOD2
50arginine449.0ALDH2, IL18, CP, GSTM1, CYP1A1, SOD2

GO Terms for genes affiliated with Oral Cavity Cancer

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16Gene Ontology
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Cellular components related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:03126510.1FADD, CASP8
2death-inducing signaling complexGO:0312649.9FADD, CASP8
3cytosolGO:0058298.9CASP8, FADD, NAT2, IL18, TAX1BP1, GPX1

Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:01026910.4SOD2, GPX1
2hydrogen peroxide biosynthetic processGO:05066510.4SOD2, CYP1A1
3activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FADD, TNFRSF10B, CASP8
5response to hyperoxiaGO:05509310.3SOD2, CYP1A1, IL18
6removal of superoxide radicalsGO:01943010.2MPO, SOD2
7positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.2CASP8, TLR6, TNFRSF10B, FADD
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.2CASP8, TNFRSF10B, FADD
9cellular response to mechanical stimulusGO:07126010.2CASP8, TNFRSF10B, FADD, IL18
10toll-like receptor signaling pathwayGO:00222410.1FADD, TLR6, CASP8, HSP90B1
11glutathione metabolic processGO:00674910.1SOD2, GPX1, GSTM1, GSTT1
12T-helper 1 type immune responseGO:04208810.1IL18, TLR6
13response to hypoxiaGO:00166610.1IL18, CYP1A1, SOD2, HSP90B1
14toll-like receptor 4 signaling pathwayGO:03414210.0CASP8, TLR6, FADD
15response to drugGO:0424939.9GSTT1, CYP2E1, CYP1A1, SOD2
16xenobiotic metabolic processGO:0068059.9GSTT1, GSTM1, ALDH2, NAT2, CYP2E1, CYP1A1
17copper ion transportGO:0068259.8CP, HEPH
18negative regulation of apoptotic processGO:0430669.7GPX1, TAX1BP1, MPO, TNFRSF6B, HSP90B1
19innate immune responseGO:0450879.6CASP8, TLR6, FADD, TAX1BP1, HSP90B1
20small molecule metabolic processGO:0442819.6GSTT1, GSTM1, ALDH2, GPX1, NAT2, CYP2E1

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.9CYP2E1, CYP1A1, HEPH
2oxygen bindingGO:0198259.7CYP2E1, CYP1A1, SOD2

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cavity Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet