MCID: ORL007
MIFTS: 61

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories

Summaries for Oral Cavity Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lung cancer and hepatitis c. An important gene associated with Oral Cavity Cancer is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are ethanol degradation II and Caffeine Pathway, Pharmacokinetics. The compounds estrogen and nadph have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and lung, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Oral Cavity Cancer

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cavity cancer 8 10
malignant neoplasm of anterior portion of floor of mouth 8
malignant neoplasm of lateral portion of floor of mouth 8
malignant neoplasm of other sites of floor of mouth 8
malignant neoplasm of lateral floor of mouth 8
malignant tumor of anterior floor of mouth 8
malignant tumor of the floor of the mouth 8
malignant neoplasm of floor of mouth, nos 8
malignant tumor of lateral floor of mouth 8
malignant neoplasm of floor of mouth nos 8
malignant neoplasm of floor of mouth 8
malignant tumor of floor of mouth 8
malignant neoplasm of mouth 60


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Disease Ontology8 DOID:8618
ICD9CM27 144, 144.9
NCIt39 C9318
ICD1025 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Oral Cavity Cancer family:

Oral Cavity Carcinoma in Situ

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.4CASP8, SOD2, CYP1A1, CYP2E1, GDF15, GSTM1
2hepatitis c30.1SOD2, CYP1A1, CYP2E1, IL18, GSTM1
3hepatitis30.1CASP8, SOD2, CYP2E1, NAT2, IL18, CP
4lymph node cancer10.5
5mandibular cancer10.3
6oropharynx cancer10.3
7lip and oral cavity cancer10.3
8lip cancer10.2
9hepatitis a10.1
10hypopharynx cancer10.1
11salivary gland cancer10.1
12age related macular degeneration10.0HEPH
13prostatitis10.0GDF15
14esophagitis10.0SOD2
15dermatitis10.0IL18
16pneumoconiosis10.0CP
17acute myocardial infarction10.0GSTM1
18fatty liver disease10.0CYP2E1
19graves' disease10.0MPO
20iron deficiency anemia10.0HEPH
21cholestasis10.0CP
22neuropathy10.0SOD2
23esophageal cancer10.0ALDH2, CYP2E1
24meningioma10.0GSTT1
25myocardial infarction10.0ALDH2, GSTT1
26primary open angle glaucoma10.0GSTM1
27schistosomiasis10.0GSTM1
28schizophrenia10.0GPX1, CP
29lupus erythematosus10.0NAT2, IL18
30psoriasis10.0IL18, NAT2
31aceruloplasminemia10.0CP, HEPH
32osteoarthritis10.0IL18, TNFRSF10B
33thyroid cancer10.0GSTT1, GSTM1
34motor neuron disease10.0SOD2, GSTT1
35medulloblastoma10.0TNFRSF10B, CASP8
36hemochromatosis10.0CP, HEPH
37asbestosis10.0GSTT1, GSTM1
38periodontal disease10.0MPO
39toxic encephalopathy10.0GPX1, SOD2
40familial adenomatous polyposis10.0NAT2, TNFRSF10B
41malignant mesothelioma10.0SOD2, TNFRSF10B, NAT2
42hyperglycemia10.0GPX1, SOD2
43insulin resistance10.0IL18, CYP2E1
44myeloma10.0TNFRSF10B, CASP8, HSP90B1
45hypercholesterolemia10.0SOD2
46colon adenocarcinoma10.0TNFRSF6B, CASP8
47coronary heart disease10.0GDF15, IL18, GSTT1
48molluscum contagiosum10.0CASP8, IL18
49cataract10.0NAT2, GPX1, GSTT1
50down syndrome10.0SOD2, GDF15, GPX1

Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Clinical Features for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oral Cavity Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Search CenterWatch for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Oral Cavity Cancer:

32
Lymph node, Lung, Testes, Salivary gland, B cells, Nk cells, Monocytes, Tongue, Bone

FMA organs/tissues related to Oral Cavity Cancer:

14
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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Sources:
36MGI
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Publications for Oral Cavity Cancer

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Sources:
50PubMed
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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy. (22730021)
2013
2
Body mass index, body mass change, and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23677332)
2013
3
Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients? (23893514)
2013
4
Multiple 'skip' lesions in oropharynx and contralateral synchronous primary in hypopharynx detected on FDG PET/CT in case of oral cavity cancer. (24379543)
2013
5
Association and prognostic value of serum inflammation markers in patients with leukoplakia and oral cavity cancer. (23154424)
2013
6
Lymph node ratio predicts the benefit of post-operative radiotherapy in oral cavity cancer. (23157979)
2013
7
Association of HPV infections with second primary tumors in early-staged oral cavity cancer. (22747969)
2012
8
Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation. (23202301)
2012
9
The diagnosis and treatment of oral cavity cancer. (23248713)
2012
10
Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. (22808258)
2012
11
Impact of a second FDG PET scan before adjuvant therapy for the early detection of residual/relapsing tumours in high-risk patients with oral cavity cancer and pathological extracapsular spread. (22434050)
2012
12
Mortality of oral cavity cancer in Iran. (22320989)
2011
13
Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. (21804026)
2011
14
Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes. (20934267)
2011
15
Impact of treatment sequence of multimodal therapy for advanced oral cavity cancer with mandible invasion. (21810773)
2011
16
Visual screening of oral cavity cancer in a male population: experience from a medical center. (22196472)
2011
17
Serum decoy receptor 3 level: a predictive marker for nodal metastasis and survival among oral cavity cancer patients. (20645287)
2011
18
Concurrent chemotherapy and intensity-modulated radiotherapy for organ preservation of locoregionally advanced oral cavity cancer. (21633289)
2011
19
Green tea (-)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met. (21292466)
2011
20
Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. (20308004)
2010
21
Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. (20798208)
2010
22
Unmet information needs and preferences in newly diagnosed and surgically treated oral cavity cancer patients. (19631574)
2009
23
Is dental care utilization associated with oral cavity cancer in a large sample of community-based United States residents? (19046335)
2009
24
Does the negative node count affect disease-free survival in early-stage oral cavity cancer? (19837320)
2009
25
Income and the incidence of oral cavity cancer: cross-national study. (19442370)
2009
26
The expressions of intrinsic and extrinsic apoptotic pathway proteins in neutrophils of oral cavity cancer patients: a preliminary study. (19479204)
2009
27
The association of smoking, alcoholic consumption, betel quid chewing and oral cavity cancer: a cohort study. (18389268)
2008
28
The impact of superficial injections of radiocolloids and dynamic lymphoscintigraphy on sentinel node identification in oral cavity cancer: a same-day protocol. (18317294)
2008
29
Using stereolithographic models to plan mandibular reconstruction for advanced oral cavity cancer. (17415150)
2007
30
Pain and its implication as a presenting symptom in oral cavity cancer. (17967398)
2007
31
Comparison of approaches for oral cavity cancer resection: lip-split versus visor flap. (17765770)
2007
32
Visual screening of oral cavity cancer: The role of otolaryngologists. (17202936)
2007
33
Fluorimetric detection of aldehyde dehydrogenase activity in human saliva in diagnostic of cancers of oral cavity. (17357596)
2006
34
Measures of health-related quality of life and functional status in survivors of oral cavity cancer who have had defects reconstructed with radial forearm free flaps. (16095776)
2006
35
Postoperative radiotherapy after titanium plate mandibular reconstruction for oral cavity cancer. (16199984)
2005
36
Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. (15792610)
2005
37
Sentinel node biopsy in oral cavity cancer: correlation with PET scan and immunohistochemistry. (12478537)
2003
38
VEGF in the culture of PMN and the serum in oral cavity cancer patients. (12167439)
2002
39
Technetium 99m single positron emission computed tomography scanning for assessing mandible invasion in oral cavity cancer. (11224764)
2001
40
A review of scales for assessment of the quality of life (QOL) in patients with oral cavity cancer. (15354494)
2001
41
High incidence of synchronous cancer of the oral cavity and the upper gastrointestinal tract. (10529014)
1999
42
Clinical-severity staging system for oral cavity cancer: five-year survival rates. (9914547)
1999
43
Re: Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. (9637146)
1998
44
Society of Surgical Oncology Practice Guidelines. Oropharyngeal and oral cavity cancer surgical practice guidelines. (9268981)
1997
45
A peculiar form of anemia in patients operated on for cancer of the oral cavity]. (9567616)
1997
46
Medilas Nd:YAG laser in oral cavity cancer. (10149801)
1991
47
Radiation therapy for oral cavity cancer. (2186932)
1990
48
Composite resection and reconstruction for oral cavity and oropharynx cancer. A functional approach. (7352901)
1980
49
The care of patients with oral cavity and lip cancer. Surgical principles. (5107504)
1971
50
The current status of block dissection of the neck in the treatment of oral cavity cancer. (5266960)
1970

Genetic Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP2E1, ALDH2
2
Hide members
10.2NAT2, CYP2E1
310.1GSTT1, GSTM1
4
Hide members
10.1CYP1A1, CYP2E1, GPX1
5
Hide members
10.0FADD, TNFRSF10B, CASP8
6
Hide members
10.0FADD, TNFRSF10B, CASP8
7
Hide members
10.0FADD, TNFRSF10B, CASP8
810.0CASP8, TNFRSF10B, FADD
9
Apoptosis and survival Apoptotic TNF-family pathways
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10.0FADD, TNFRSF10B, CASP8
10
Hide members
10.0CYP1A1, CYP2E1, ALDH2
11
Retinol metabolism
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10.0CYP1A1, CYP2E1, ALDH2
12
Hide members
10.0ALDH2, CYP2E1, CYP1A1
13
Acetaminophen metabolism
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10.0NAT2, CYP2E1, CYP1A1
14
Hide members
10.0NAT2, CYP2E1, CYP1A1
1510.0SOD2, CYP1A1, GPX1
16
Glutathione metabolism
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10.0GPX1, GSTM1, GSTT1
1710.0TAX1BP1, TNFRSF10B, TLR6
18
Hide members
10.0TLR6, CASP8, HSP90B1
1910.0SOD2, MPO, GPX1
20
Apoptosis and survival Caspase cascade
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9.9FADD, TNFRSF6B, CASP8
21
Hide members
9.9IL18, CASP8, HSP90B1
22
Hide members
9.9FADD, TNFRSF10B, TLR6, CASP8
239.9MPO, GSTM1, GSTT1
24
Hide members
9.9TLR6, TNFRSF6B, TNFRSF10B, FADD
259.9CASP8, TLR6, FADD, IL18
26
Hide members
9.8HSP90B1, CASP8, TLR6, FADD
27
Hide members
9.8CASP8, TNFRSF6B, TNFRSF10B, FADD
28
Hide members
9.8FADD, TNFRSF10B, TNFRSF6B, CASP8
29
Naphthalene metabolism
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9.8CYP1A1, CYP2E1, GSTM1, GSTT1
30
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9.7CASP8, SOD2, FADD, CYP2E1, GPX1
31
Hide members
9.7CYP1A1, CYP2E1, NAT2, GSTM1, GSTT1
32
Hide members
9.5CYP1A1, CYP2E1, NAT2, ALDH2, GSTM1, GSTT1
339.4TAX1BP1, GDF15, FADD, TNFRSF10B, TNFRSF6B, CASP8
34
Hide members
9.4HSP90B1, CASP8, TLR6, FADD, IL18, TAX1BP1

Compounds for genes affiliated with Oral Cavity Cancer

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GDF15
2nadph44 2411.4GPX1, SOD2
3indomethacin44 59 28 1113.3GDF15
4drugs for treatment of tuberculosis4910.3GSTM1, GSTT1, NAT2
5trans,trans-muconic acid4410.3CYP2E1, GSTT1, GSTM1
6vinylchloride4410.2CYP2E1, ALDH2, GSTM1, GSTT1
7toluene4410.2CYP2E1, ALDH2, GSTM1, GSTT1
8styrene4410.2CYP2E1, NAT2, GSTT1, GSTM1
9s-phenylmercapturic acid4410.2GSTT1, CYP2E1, GSTM1
10debrisoquine4410.2CYP2E1, NAT2, GSTM1, CYP1A1
11trichloroethylene4410.2GSTT1, CYP2E1, NAT2, GSTM1
12buthionine sulfoximine4410.1SOD2, CYP2E1, CASP8, GPX1
13isoniazid49 44 1112.1CYP2E1, GSTM1, GSTT1, NAT2
148-oxo-dg4410.1GPX1, GSTM1, GSTT1, SOD2
15benzene4410.1NAT2, GSTM1, CYP2E1, GSTT1
161-hydroxypyrene4410.1GSTT1, NAT2, CYP1A1, CYP2E1, GSTM1
17acetone4410.1GSTT1, CYP1A1, CYP2E1, GSTM1
18rsai4410.1CYP2E1, ALDH2, GSTT1, GSTM1, NAT2
19mspi4410.1CYP2E1, GSTT1, NAT2, CYP1A1, GSTM1
20cyclophosphamide44 49 1112.1GSTM1, GSTT1, CYP1A1, CYP2E1, SOD2
21butadiene monoxide4410.0GSTT1, GSTM1, CYP2E1
22hydrocarbons4410.0GSTM1, NAT2, CYP1A1, GSTT1
23epoxide4410.0GSTT1, GSTM1, NAT2, CYP1A1, CYP2E1
24creatinine4410.0GSTM1, ALDH2, CYP2E1, GSTT1, CP
25butyrate4410.0SOD2
26vitamin a44 11 2412.0SOD2, CYP1A1, CYP2E1, NAT2, ALDH2, CP
27alpha tocopherol449.9CP, GSTM1, ALDH2, GPX1, SOD2, CYP1A1
284-hydroxynonenal44 2410.9GPX1, SOD2, ALDH2, GSTM1, CYP2E1, MPO
29valproic acid44 49 11 2412.9CYP1A1, CASP8, TNFRSF10B, CYP2E1, CP
30malondialdehyde449.9GSTM1, SOD2, GSTT1, GPX1, CP, MPO
31gsts449.8GSTT1, GSTM1, ALDH2, GPX1, CYP1A1, CYP2E1
32methimazole44 2 1111.8CP, IL18, MPO, CYP2E1
33ethanol44 49 11 2412.7ALDH2, HSP90B1, FADD, CYP1A1, GSTT1, IL18
34oxaliplatin44 49 1111.7GSTT1, CASP8, TNFRSF10B, MPO, CYP1A1, CYP2E1
35folate449.7ALDH2, GSTM1, CP, IL18, NAT2, SOD2
36n acetylcysteine449.7MPO, CASP8, SOD2, IL18, CYP1A1, TNFRSF10B
375fluorouracil449.7MPO, IL18, SOD2, CASP8, GSTM1, FADD
38ascorbic acid44 2410.6SOD2, CYP2E1, MPO, CYP1A1, CP, GSTM1
39doxorubicin44 49 1111.6GSTT1, CASP8, GSTM1, GPX1, IL18, FADD
40oxygen44 2410.6FADD, TNFRSF10B, HSP90B1, MPO, CYP1A1, ALDH2
41betacarotene449.6SOD2, CYP1A1, GSTM1, CYP2E1, NAT2, ALDH2
42iron44 2410.5SOD2, GDF15, CP, GPX1, IL18, HEPH
43superoxide44 2410.4CASP8, CP, ALDH2, SOD2, GPX1, MPO
44lactate449.4SOD2, MPO, CYP2E1, GSTM1, CP, IL18
45cisplatin44 49 59 1112.4CASP8, SOD2, TNFRSF10B, FADD, MPO, CYP1A1
46retinoic acid44 2410.3TNFRSF10B, MPO, CASP8, CYP2E1, CYP1A1, IL18
47cysteine449.3GPX1, NAT2, IL18, CASP8, SOD2, FADD
48h2o2449.2CYP1A1, CYP2E1, GSTM1, CP, GPX1, IL18
49lipid449.2IL18, HSP90B1, CYP2E1, TNFRSF10B, FADD, TLR6
50arginine449.0GSTT1, ALDH2, CP, GSTM1, CASP8, SOD2

GO Terms for genes affiliated with Oral Cavity Cancer

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Sources:
16Gene Ontology
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Cellular components related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:03126510.1FADD, CASP8
2death-inducing signaling complexGO:0312649.9FADD, CASP8
3cytosolGO:0058298.9CASP8, FADD, NAT2, IL18, TAX1BP1, GPX1

Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:01026910.4SOD2, GPX1
2hydrogen peroxide biosynthetic processGO:05066510.4SOD2, CYP1A1
3activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FADD, TNFRSF10B, CASP8
5response to hyperoxiaGO:05509310.3SOD2, CYP1A1, IL18
6removal of superoxide radicalsGO:01943010.2MPO, SOD2
7positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.2CASP8, TLR6, TNFRSF10B, FADD
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.2CASP8, TNFRSF10B, FADD
9cellular response to mechanical stimulusGO:07126010.2CASP8, TNFRSF10B, FADD, IL18
10toll-like receptor signaling pathwayGO:00222410.1FADD, TLR6, CASP8, HSP90B1
11glutathione metabolic processGO:00674910.1SOD2, GPX1, GSTM1, GSTT1
12T-helper 1 type immune responseGO:04208810.1IL18, TLR6
13response to hypoxiaGO:00166610.1IL18, CYP1A1, SOD2, HSP90B1
14toll-like receptor 4 signaling pathwayGO:03414210.0CASP8, TLR6, FADD
15response to drugGO:0424939.9GSTT1, CYP2E1, CYP1A1, SOD2
16xenobiotic metabolic processGO:0068059.9GSTT1, GSTM1, ALDH2, NAT2, CYP2E1, CYP1A1
17copper ion transportGO:0068259.8CP, HEPH
18negative regulation of apoptotic processGO:0430669.7GPX1, TAX1BP1, MPO, TNFRSF6B, HSP90B1
19innate immune responseGO:0450879.6CASP8, TLR6, FADD, TAX1BP1, HSP90B1
20small molecule metabolic processGO:0442819.6GSTT1, GSTM1, ALDH2, GPX1, NAT2, CYP2E1

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.9CYP2E1, CYP1A1, HEPH
2oxygen bindingGO:0198259.7CYP2E1, CYP1A1, SOD2

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cavity Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet