MCID: ORL007
MIFTS: 61

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories

Summaries for Oral Cavity Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lung cancer and hepatitis c. An important gene associated with Oral Cavity Cancer is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are ethanol degradation II and Caffeine Pathway, Pharmacokinetics. The compounds estrogen and nadph have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and lung, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Oral Cavity Cancer

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cavity cancer 8 10
malignant neoplasm of anterior portion of floor of mouth 8
malignant neoplasm of lateral portion of floor of mouth 8
malignant neoplasm of other sites of floor of mouth 8
malignant neoplasm of lateral floor of mouth 8
malignant tumor of anterior floor of mouth 8
malignant tumor of the floor of the mouth 8
malignant neoplasm of floor of mouth, nos 8
malignant tumor of lateral floor of mouth 8
malignant neoplasm of floor of mouth nos 8
malignant neoplasm of floor of mouth 8
malignant tumor of floor of mouth 8
malignant neoplasm of mouth 60


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Disease Ontology8 DOID:8618
ICD9CM27 144, 144.9
NCIt39 C9318
ICD1025 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Oral Cavity Cancer family:

Oral Cavity Carcinoma in Situ

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.4CASP8, SOD2, CYP1A1, CYP2E1, GDF15, GSTM1
2hepatitis c30.1SOD2, CYP1A1, CYP2E1, IL18, GSTM1
3hepatitis30.1CASP8, SOD2, CYP2E1, NAT2, IL18, CP
4lymph node cancer10.5
5mandibular cancer10.3
6oropharynx cancer10.3
7lip and oral cavity cancer10.3
8lip cancer10.2
9hepatitis a10.1
10hypopharynx cancer10.1
11salivary gland cancer10.1
12age related macular degeneration10.0HEPH
13prostatitis10.0GDF15
14esophagitis10.0SOD2
15dermatitis10.0IL18
16pneumoconiosis10.0CP
17acute myocardial infarction10.0GSTM1
18fatty liver disease10.0CYP2E1
19graves' disease10.0MPO
20iron deficiency anemia10.0HEPH
21cholestasis10.0CP
22neuropathy10.0SOD2
23esophageal cancer10.0ALDH2, CYP2E1
24meningioma10.0GSTT1
25myocardial infarction10.0ALDH2, GSTT1
26primary open angle glaucoma10.0GSTM1
27schistosomiasis10.0GSTM1
28schizophrenia10.0GPX1, CP
29lupus erythematosus10.0NAT2, IL18
30psoriasis10.0IL18, NAT2
31aceruloplasminemia10.0CP, HEPH
32osteoarthritis10.0IL18, TNFRSF10B
33thyroid cancer10.0GSTT1, GSTM1
34motor neuron disease10.0SOD2, GSTT1
35medulloblastoma10.0TNFRSF10B, CASP8
36hemochromatosis10.0CP, HEPH
37asbestosis10.0GSTT1, GSTM1
38periodontal disease10.0MPO
39toxic encephalopathy10.0GPX1, SOD2
40familial adenomatous polyposis10.0NAT2, TNFRSF10B
41malignant mesothelioma10.0SOD2, TNFRSF10B, NAT2
42hyperglycemia10.0GPX1, SOD2
43insulin resistance10.0IL18, CYP2E1
44myeloma10.0TNFRSF10B, CASP8, HSP90B1
45hypercholesterolemia10.0SOD2
46colon adenocarcinoma10.0TNFRSF6B, CASP8
47coronary heart disease10.0GDF15, IL18, GSTT1
48molluscum contagiosum10.0CASP8, IL18
49cataract10.0NAT2, GPX1, GSTT1
50down syndrome10.0SOD2, GDF15, GPX1

Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Clinical Features for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Oral Cavity Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Search CenterWatch for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Oral Cavity Cancer:

32
Lymph node, Lung, Testes, Salivary gland, B cells, Nk cells, Monocytes, Tongue, Bone

FMA organs/tissues related to Oral Cavity Cancer:

14
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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Sources:
36MGI
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Publications for Oral Cavity Cancer

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50PubMed
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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Selective use of postoperative neck radiotherapy in oral cavity and oropharynx cancer: a prospective clinical study. (23621873)
2013
2
Comparative outcomes in oral cavity cancer with resected pT4a and pT4b. (23063612)
2013
3
Apoptosis inhibitor showed a significant prognostic marker of relapsed oral cavity cancer after the curative resection surgery. (23991597)
2013
4
Change and predictors of social support in caregivers of newly diagnosed oral cavity cancer patients during the first 3 months after discharge. (23047794)
2013
5
Pitfalls in the staging of cancer of oral cavity cancer. (23199660)
2013
6
Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. (24258195)
2013
7
An extremely rare, remote intracerebral metastasis of oral cavity cancer: a case report. (24222770)
2013
8
Association of HPV infections with second primary tumors in early-staged oral cavity cancer. (22747969)
2012
9
Follow up after IMRT in oral cavity cancer: update. (22686297)
2012
10
Impact of smoking status on clinical outcome in oral cavity cancer patients. (21996543)
2012
11
Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan. (23133554)
2012
12
Low body mass index at 3 months following adjuvant chemoradiation affects survival of postoperative locally advanced oral cavity cancer patients. (22886710)
2012
13
Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy. (22104249)
2012
14
Identification of a high-risk subgroup of patients with resected pT3 oral cavity cancer in need of postoperative adjuvant therapy. (21360248)
2011
15
Comparison between free flap and pectoralis major pedicled flap for reconstruction in oral cavity cancer patients--a quality of life analysis. (21498107)
2011
16
Comparison of antioxidant enzymes activity and the concentration of uric acid in the saliva of patients with oral cavity cancer, odontogenic cysts and healthy subjects. (21501233)
2011
17
Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. (21269518)
2011
18
Epidermal growth factor receptor mutations in patients with oral cavity cancer in a betel nut chewing-prevalent area. (21284055)
2011
19
Overexpression of B cell-activating factor (BAFF) in neutrophils of oral cavity cancer patients - preliminary study. (21391737)
2011
20
Chemoradiation for patients with advanced oral cavity cancer. (19856305)
2010
21
High-risk HPV DNA status and p16 (INK4a) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx. (21225495)
2010
22
Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. (18805047)
2009
23
Alcohol intake and oral cavity cancer risk among men in a prospective study in Kerala, India. (19486349)
2009
24
Analysis of risk factors of predictive local tumor control in oral cavity cancer. (18165878)
2008
25
Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? (18474310)
2008
26
Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion. (18841160)
2008
27
The release of soluble forms of TRAIL and DR5 by neutrophils of oral cavity cancer patients. (18519235)
2008
28
Tumor volume assessment by 18F-FDG PET/CT in patients with oral cavity cancer with dental artifacts on CT or MR images. (18703597)
2008
29
Risk factors for wound infection after surgery in primary oral cavity cancer patients. (17202947)
2007
30
IMRT in oral cavity cancer. (17430599)
2007
31
Alphavbeta6 integrin in wound healing and cancer of the oral cavity. (16393247)
2006
32
15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells. (16472553)
2006
33
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. (15598591)
2005
34
VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer. (15826815)
2005
35
Statherin levels in saliva of patients with precancerous and cancerous lesions of the oral cavity: a preliminary report. (15752082)
2005
36
A preliminary study on sentinel lymph node biopsy: feasibility and predictive ability in oral cavity cancer. (15233288)
2004
37
Evaluation of serum sialic acid, sialyltransferase and sialoproteins in oral cavity cancer. (12945593)
2003
38
Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. (11891947)
2002
39
Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. (12110344)
2002
40
Distant metastases from lip and oral cavity cancer. (11408816)
2001
41
Metabolic polymorphisms as susceptibility markers for lung and oral cavity cancer. (11220667)
2001
42
Tobacco habits and risk of lung, oropharyngeal and oral cavity cancer: a population-based case-control study in Bhopal, India. (10922335)
2000
43
Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. (10470985)
1999
44
Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity. (10705094)
1999
45
Biological markers as indicators of pathological response to primary chemotherapy in oral-cavity cancers. (9842971)
1998
46
Soluble IL-6 receptor release by PMNs and PBMC in patients with oral cavity cancer. (9581469)
1997
47
A simple risk estimates study for oral cavity cancer: practical approach in Indian context. (9212572)
1997
48
Differing views of radiation vs surgery for oral cavity cancer. (3275057)
1988
49
Functional analysis of treatment of oral cavity cancer. (3741662)
1986
50
Studies of metronidazole radiosensitizing effect in radiation treatment of patients with oral cavity cancer. (3982556)
1985

Genetic Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP2E1, ALDH2
2
Hide members
10.2NAT2, CYP2E1
310.1GSTT1, GSTM1
4
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10.1CYP1A1, CYP2E1, GPX1
5
Hide members
10.0FADD, TNFRSF10B, CASP8
6
Hide members
10.0FADD, TNFRSF10B, CASP8
7
Hide members
10.0FADD, TNFRSF10B, CASP8
810.0CASP8, TNFRSF10B, FADD
9
Apoptosis and survival Apoptotic TNF-family pathways
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10.0FADD, TNFRSF10B, CASP8
10
Hide members
10.0CYP1A1, CYP2E1, ALDH2
11
Retinol metabolism
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10.0CYP1A1, CYP2E1, ALDH2
12
Hide members
10.0ALDH2, CYP2E1, CYP1A1
13
Acetaminophen metabolism
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10.0NAT2, CYP2E1, CYP1A1
14
Hide members
10.0NAT2, CYP2E1, CYP1A1
1510.0SOD2, CYP1A1, GPX1
16
Glutathione metabolism
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10.0GPX1, GSTM1, GSTT1
1710.0TAX1BP1, TNFRSF10B, TLR6
18
Hide members
10.0TLR6, CASP8, HSP90B1
1910.0SOD2, MPO, GPX1
20
Apoptosis and survival Caspase cascade
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9.9FADD, TNFRSF6B, CASP8
21
Hide members
9.9IL18, CASP8, HSP90B1
22
Hide members
9.9FADD, TNFRSF10B, TLR6, CASP8
239.9MPO, GSTM1, GSTT1
24
Hide members
9.9TLR6, TNFRSF6B, TNFRSF10B, FADD
259.9CASP8, TLR6, FADD, IL18
26
Hide members
9.8HSP90B1, CASP8, TLR6, FADD
27
Hide members
9.8CASP8, TNFRSF6B, TNFRSF10B, FADD
28
Hide members
9.8FADD, TNFRSF10B, TNFRSF6B, CASP8
29
Naphthalene metabolism
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9.8CYP1A1, CYP2E1, GSTM1, GSTT1
30
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9.7CASP8, SOD2, FADD, CYP2E1, GPX1
31
Hide members
9.7CYP1A1, CYP2E1, NAT2, GSTM1, GSTT1
32
Hide members
9.5CYP1A1, CYP2E1, NAT2, ALDH2, GSTM1, GSTT1
339.4TAX1BP1, GDF15, FADD, TNFRSF10B, TNFRSF6B, CASP8
34
Hide members
9.4HSP90B1, CASP8, TLR6, FADD, IL18, TAX1BP1

Compounds for genes affiliated with Oral Cavity Cancer

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GDF15
2nadph44 2411.4GPX1, SOD2
3indomethacin44 59 28 1113.3GDF15
4drugs for treatment of tuberculosis4910.3GSTM1, GSTT1, NAT2
5trans,trans-muconic acid4410.3CYP2E1, GSTT1, GSTM1
6vinylchloride4410.2CYP2E1, ALDH2, GSTM1, GSTT1
7toluene4410.2CYP2E1, ALDH2, GSTM1, GSTT1
8styrene4410.2CYP2E1, NAT2, GSTT1, GSTM1
9s-phenylmercapturic acid4410.2GSTT1, CYP2E1, GSTM1
10debrisoquine4410.2CYP2E1, NAT2, GSTM1, CYP1A1
11trichloroethylene4410.2GSTT1, CYP2E1, NAT2, GSTM1
12buthionine sulfoximine4410.1SOD2, CYP2E1, CASP8, GPX1
13isoniazid49 44 1112.1CYP2E1, GSTM1, GSTT1, NAT2
148-oxo-dg4410.1GPX1, GSTM1, GSTT1, SOD2
15benzene4410.1NAT2, GSTM1, CYP2E1, GSTT1
161-hydroxypyrene4410.1GSTT1, NAT2, CYP1A1, CYP2E1, GSTM1
17acetone4410.1GSTT1, CYP1A1, CYP2E1, GSTM1
18rsai4410.1CYP2E1, ALDH2, GSTT1, GSTM1, NAT2
19mspi4410.1CYP2E1, GSTT1, NAT2, CYP1A1, GSTM1
20cyclophosphamide44 49 1112.1GSTM1, GSTT1, CYP1A1, CYP2E1, SOD2
21butadiene monoxide4410.0GSTT1, GSTM1, CYP2E1
22hydrocarbons4410.0GSTM1, NAT2, CYP1A1, GSTT1
23epoxide4410.0GSTT1, GSTM1, NAT2, CYP1A1, CYP2E1
24creatinine4410.0GSTM1, ALDH2, CYP2E1, GSTT1, CP
25butyrate4410.0SOD2
26vitamin a44 11 2412.0SOD2, CYP1A1, CYP2E1, NAT2, ALDH2, CP
27alpha tocopherol449.9CP, GSTM1, ALDH2, GPX1, SOD2, CYP1A1
284-hydroxynonenal44 2410.9GPX1, SOD2, ALDH2, GSTM1, CYP2E1, MPO
29valproic acid44 49 11 2412.9CYP1A1, CASP8, TNFRSF10B, CYP2E1, CP
30malondialdehyde449.9GSTM1, SOD2, GSTT1, GPX1, CP, MPO
31gsts449.8GSTT1, GSTM1, ALDH2, GPX1, CYP1A1, CYP2E1
32methimazole44 2 1111.8CP, IL18, MPO, CYP2E1
33ethanol44 49 11 2412.7ALDH2, HSP90B1, FADD, CYP1A1, GSTT1, IL18
34oxaliplatin44 49 1111.7GSTT1, CASP8, TNFRSF10B, MPO, CYP1A1, CYP2E1
35folate449.7ALDH2, GSTM1, CP, IL18, NAT2, SOD2
36n acetylcysteine449.7MPO, CASP8, SOD2, IL18, CYP1A1, TNFRSF10B
375fluorouracil449.7MPO, IL18, SOD2, CASP8, GSTM1, FADD
38ascorbic acid44 2410.6SOD2, CYP2E1, MPO, CYP1A1, CP, GSTM1
39doxorubicin44 49 1111.6GSTT1, CASP8, GSTM1, GPX1, IL18, FADD
40oxygen44 2410.6FADD, TNFRSF10B, HSP90B1, MPO, CYP1A1, ALDH2
41betacarotene449.6SOD2, CYP1A1, GSTM1, CYP2E1, NAT2, ALDH2
42iron44 2410.5SOD2, GDF15, CP, GPX1, IL18, HEPH
43superoxide44 2410.4CASP8, CP, ALDH2, SOD2, GPX1, MPO
44lactate449.4SOD2, MPO, CYP2E1, GSTM1, CP, IL18
45cisplatin44 49 59 1112.4CASP8, SOD2, TNFRSF10B, FADD, MPO, CYP1A1
46retinoic acid44 2410.3TNFRSF10B, MPO, CASP8, CYP2E1, CYP1A1, IL18
47cysteine449.3GPX1, NAT2, IL18, CASP8, SOD2, FADD
48h2o2449.2CYP1A1, CYP2E1, GSTM1, CP, GPX1, IL18
49lipid449.2IL18, HSP90B1, CYP2E1, TNFRSF10B, FADD, TLR6
50arginine449.0GSTT1, ALDH2, CP, GSTM1, CASP8, SOD2

GO Terms for genes affiliated with Oral Cavity Cancer

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Sources:
16Gene Ontology
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Cellular components related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:03126510.1FADD, CASP8
2death-inducing signaling complexGO:0312649.9FADD, CASP8
3cytosolGO:0058298.9CASP8, FADD, NAT2, IL18, TAX1BP1, GPX1

Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:01026910.4SOD2, GPX1
2hydrogen peroxide biosynthetic processGO:05066510.4SOD2, CYP1A1
3activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FADD, TNFRSF10B, CASP8
5response to hyperoxiaGO:05509310.3SOD2, CYP1A1, IL18
6removal of superoxide radicalsGO:01943010.2MPO, SOD2
7positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.2CASP8, TLR6, TNFRSF10B, FADD
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.2CASP8, TNFRSF10B, FADD
9cellular response to mechanical stimulusGO:07126010.2CASP8, TNFRSF10B, FADD, IL18
10toll-like receptor signaling pathwayGO:00222410.1FADD, TLR6, CASP8, HSP90B1
11glutathione metabolic processGO:00674910.1SOD2, GPX1, GSTM1, GSTT1
12T-helper 1 type immune responseGO:04208810.1IL18, TLR6
13response to hypoxiaGO:00166610.1IL18, CYP1A1, SOD2, HSP90B1
14toll-like receptor 4 signaling pathwayGO:03414210.0CASP8, TLR6, FADD
15response to drugGO:0424939.9GSTT1, CYP2E1, CYP1A1, SOD2
16xenobiotic metabolic processGO:0068059.9GSTT1, GSTM1, ALDH2, NAT2, CYP2E1, CYP1A1
17copper ion transportGO:0068259.8CP, HEPH
18negative regulation of apoptotic processGO:0430669.7GPX1, TAX1BP1, MPO, TNFRSF6B, HSP90B1
19innate immune responseGO:0450879.6CASP8, TLR6, FADD, TAX1BP1, HSP90B1
20small molecule metabolic processGO:0442819.6GSTT1, GSTM1, ALDH2, GPX1, NAT2, CYP2E1

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.9CYP2E1, CYP1A1, HEPH
2oxygen bindingGO:0198259.7CYP2E1, CYP1A1, SOD2

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cavity Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet