MCID: ORL007
MIFTS: 50

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories
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Summaries for Oral Cavity Cancer

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Disease Ontology:8 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards based summary: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lip and oral cavity cancer and hepatitis. An important gene associated with Oral Cavity Cancer is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are Apoptosis and survival Caspase cascade and Lymphocyte Signaling. The compounds sulindac sulfide and sulindac have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Oral Cavity Cancer

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Oral Cavity Cancer, Aliases & Descriptions:

Name: Oral Cavity Cancer 8 10
Malignant Neoplasm of Anterior Portion of Floor of Mouth 8 62
Malignant Neoplasm of Lateral Portion of Floor of Mouth 8 62
Malignant Neoplasm of Lateral Floor of Mouth 8 62
Malignant Tumor of Anterior Floor of Mouth 8 62
 
Malignant Tumor of the Floor of the Mouth 8 62
Malignant Tumor of Lateral Floor of Mouth 8 62
Malignant Neoplasm of Floor of Mouth 8 62
Malignant Neoplasm of Mouth 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:8618
NCIt39 C9318
ICD9CM27 144, 144.9
ICD1025 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Symptoms for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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MalaCards organs/tissues related to Oral Cavity Cancer:

32
Lymph node, Neutrophil, Lung, Testes, Bone, Salivary gland, Monocytes, Nk cells, B cells

FMA organs/tissues related to Oral Cavity Cancer:

14
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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MGI Mouse Phenotypes related to Oral Cavity Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1FADD, TNFRSF10B, GPX1, TLR6
2MP:00053977.2FADD, TNFRSF10B, GPX1, TLR6, GDF15

Publications for Oral Cavity Cancer

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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Sentinel node biopsy for early-stage oral cavity cancer: the VU University Medical Center experience. (24677355)
2014
2
Lymph node ratio as a valuable additional predictor of outcome in selected patients with oral cavity cancer. (24842444)
2014
3
Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. (24706327)
2014
4
Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases. (25257901)
2014
5
Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. (24064974)
2013
6
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer? (23346903)
2013
7
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. (23733351)
2013
8
Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy. (22730021)
2013
9
Accuracy of 3 Month Posttherapy FDG PET/CT in Resected Oral Cavity Cancer Patients Who Received Adjuvant Radiation. (24674525)
2013
10
Body mass index, body mass change, and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23677332)
2013
11
Assessment of quality of life of patients with oral cavity cancer who have had defects reconstructed with free anterolateral thigh perforator flaps. (23107622)
2013
12
Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients? (23893514)
2013
13
Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction. (22565542)
2012
14
Association of HPV infections with second primary tumors in early-staged oral cavity cancer. (22747969)
2012
15
The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. (21500194)
2012
16
Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation. (23202301)
2012
17
Effects of multidisciplinary care on the survival of patients with oral cavity cancer in Taiwan. (22534006)
2012
18
Identification of a high-risk subgroup of patients with resected pT3 oral cavity cancer in need of postoperative adjuvant therapy. (21360248)
2011
19
The roles of hope and optimism on posttraumatic growth in oral cavity cancer patients. (21183398)
2011
20
Mortality of oral cavity cancer in Iran. (22320989)
2011
21
Oral cavity cancer risk in relation to tobacco chewing and bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. (21129124)
2011
22
Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. (21804026)
2011
23
Comparison between free flap and pectoralis major pedicled flap for reconstruction in oral cavity cancer patients--a quality of life analysis. (21498107)
2011
24
Comparison of antioxidant enzymes activity and the concentration of uric acid in the saliva of patients with oral cavity cancer, odontogenic cysts and healthy subjects. (21501233)
2011
25
Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. (20308004)
2010
26
Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. (19585476)
2010
27
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. (20336792)
2010
28
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. (19259098)
2009
29
Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. (18805047)
2009
30
Alcohol intake and oral cavity cancer risk among men in a prospective study in Kerala, India. (19486349)
2009
31
Analysis of risk factors of predictive local tumor control in oral cavity cancer. (18165878)
2008
32
Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? (18474310)
2008
33
Oral cavity cancer. (17893592)
2007
34
Using stereolithographic models to plan mandibular reconstruction for advanced oral cavity cancer. (17415150)
2007
35
Long-term survival in locally advanced oral cavity cancer: an analysis of patients treated with neoadjuvant cisplatin-based chemotherapy followed by surgery. (15880411)
2005
36
Postoperative radiotherapy after titanium plate mandibular reconstruction for oral cavity cancer. (16199984)
2005
37
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. (15598591)
2005
38
Salivary epidermal growth factor in oral cavity cancer. (15598585)
2005
39
Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. (16118155)
2005
40
Oral cavity cancer. (16361136)
2005
41
Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. (15792610)
2005
42
Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. (15342664)
2004
43
Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. (12915878)
2003
44
Distant metastases from lip and oral cavity cancer. (11408816)
2001
45
Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. (10470985)
1999
46
Soluble IL-6 receptor release by PMNs and PBMC in patients with oral cavity cancer. (9581469)
1997
47
Oral cavity cancer: 234 patients treated with radiotherapy alone with curative intent. (3076686)
1988
48
Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. (3829319)
1987
49
Functional analysis of treatment of oral cavity cancer. (3741662)
1986
50
New test series for the functional evaluation of oral cavity cancer. (4066369)
1985

Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.6FADD, TNFRSF6B
29.4GPX1, GDF15
39.4TLR6, FADD
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.2FADD, TNFRSF10B
5
Show member pathways
9.2FADD, TNFRSF10B
69.2TNFRSF10B, FADD
7
Show member pathways
TRAIL signaling pathway37
9.2FADD, TNFRSF10B
8
Show member pathways
9.2FADD, TNFRSF10B
99.0TLR6, TNFRSF10B
10
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.8FADD, TNFRSF6B, TNFRSF10B
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.8TNFRSF10B, TNFRSF6B, FADD
12
Show member pathways
8.8FADD, TNFRSF6B, TNFRSF10B
138.6GDF15, GPX1, TNFRSF10B
14
Show member pathways
8.6FADD, TNFRSF10B, TLR6
15
Show member pathways
8.6TLR6, TNFRSF10B, FADD
168.3GDF15, TNFRSF10B, TNFRSF6B, FADD
17
Show member pathways
8.2FADD, TNFRSF6B, TNFRSF10B, TLR6

Compounds for genes affiliated with Oral Cavity Cancer

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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulindac sulfide449.3TNFRSF10B, GDF15
2sulindac44 1110.1TNFRSF10B, GDF15
3sp 60012544 6110.1FADD, TNFRSF10B
4ceramide448.9FADD, TNFRSF10B, GPX1
5phosphatidylinositol448.8GDF15, TNFRSF6B, FADD
6doxorubicin44 50 1110.8GPX1, TNFRSF10B, FADD
7oxygen44 249.7FADD, TNFRSF10B, GPX1
8lipid448.1TLR6, GPX1, TNFRSF10B, FADD

GO Terms for genes affiliated with Oral Cavity Cancer

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Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.4FADD, TNFRSF10B
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3FADD, TNFRSF10B
3cellular response to mechanical stimulusGO:0712609.3FADD, TNFRSF10B
4toll-like receptor 4 signaling pathwayGO:0341429.3TLR6, FADD
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3TNFRSF10B, FADD
6activation of NF-kappaB-inducing kinase activityGO:0072509.2TLR6, TNFRSF10B
7apoptotic signaling pathwayGO:0971909.2FADD, TNFRSF10B
8toll-like receptor signaling pathwayGO:0022249.1FADD, TLR6
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8FADD, TNFRSF10B, TLR6
10apoptotic processGO:0069158.8FADD, TNFRSF6B, TNFRSF10B

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048728.6TNFRSF6B, TNFRSF10B, TLR6

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Oral Cavity Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet