MCID: ORL007
MIFTS: 49

Oral Cavity Cancer malady

Cancer diseases, Oral diseases categories

Summaries for Oral Cavity Cancer

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to lip and oral cavity cancer and hepatitis c. An important gene associated with Oral Cavity Cancer is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are Apoptosis and survival Caspase cascade and Lymphocyte Signaling. The compounds sulindac sulfide and sulindac have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, lymph node and lung, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Oral Cavity Cancer

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral cavity cancer 9 11
malignant neoplasm of anterior portion of floor of mouth 9
malignant neoplasm of lateral portion of floor of mouth 9
malignant neoplasm of other sites of floor of mouth 9
malignant neoplasm of lateral floor of mouth 9
malignant tumor of anterior floor of mouth 9
malignant tumor of the floor of the mouth 9
malignant neoplasm of floor of mouth, nos 9
malignant tumor of lateral floor of mouth 9
malignant neoplasm of floor of mouth nos 9
malignant neoplasm of floor of mouth 9
malignant tumor of floor of mouth 9
malignant neoplasm of mouth 63


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Disease Ontology9 DOID:8618
ICD9CM28 144, 144.9
NCIt41 C9318
ICD1026 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Symptoms for Oral Cavity Cancer

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Drugs & Therapeutics for Oral Cavity Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Oral Cavity Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Search CenterWatch for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

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Anatomical Context for Oral Cavity Cancer

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Oral Cavity Cancer:

34
Lymph node, Lung, Testes, Bone, Salivary gland, Monocytes, Nk cells, B cells

FMA organs/tissues related to Oral Cavity Cancer:

15
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Oral Cavity Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1FADD, TNFRSF10B, GPX1, TLR6
2MP:00053977.2FADD, TNFRSF10B, GPX1, TLR6, GDF15

Publications for Oral Cavity Cancer

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Sources:
53PubMed
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Articles related to Oral Cavity Cancer:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. (24064974)
2013
2
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer? (23346903)
2013
3
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. (23733351)
2013
4
Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy. (22730021)
2013
5
Body mass index, body mass change, and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23677332)
2013
6
Assessment of quality of life of patients with oral cavity cancer who have had defects reconstructed with free anterolateral thigh perforator flaps. (23107622)
2013
7
Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients? (23893514)
2013
8
Tea and coffee consumption and risk of oral cavity cancer: results of a large population-based case-control study, the ICARE study. (23453554)
2013
9
Survival of patients with oral cavity cancer in Germany. (23349710)
2013
10
Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction. (22565542)
2012
11
Association of HPV infections with second primary tumors in early-staged oral cavity cancer. (22747969)
2012
12
The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. (21500194)
2012
13
Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation. (23202301)
2012
14
Effects of multidisciplinary care on the survival of patients with oral cavity cancer in Taiwan. (22534006)
2012
15
Identification of a high-risk subgroup of patients with resected pT3 oral cavity cancer in need of postoperative adjuvant therapy. (21360248)
2011
16
The roles of hope and optimism on posttraumatic growth in oral cavity cancer patients. (21183398)
2011
17
Mortality of oral cavity cancer in Iran. (22320989)
2011
18
Oral cavity cancer risk in relation to tobacco chewing and bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. (21129124)
2011
19
Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. (21804026)
2011
20
Comparison between free flap and pectoralis major pedicled flap for reconstruction in oral cavity cancer patients--a quality of life analysis. (21498107)
2011
21
Comparison of antioxidant enzymes activity and the concentration of uric acid in the saliva of patients with oral cavity cancer, odontogenic cysts and healthy subjects. (21501233)
2011
22
Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. (20308004)
2010
23
Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. (19585476)
2010
24
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. (20336792)
2010
25
Posttraumatic growth: a novel concept in oral cavity cancer care? (20850373)
2010
26
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. (19259098)
2009
27
Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. (18805047)
2009
28
Alcohol intake and oral cavity cancer risk among men in a prospective study in Kerala, India. (19486349)
2009
29
Analysis of risk factors of predictive local tumor control in oral cavity cancer. (18165878)
2008
30
Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? (18474310)
2008
31
Oral cavity cancer. (17893592)
2007
32
Long-term survival in locally advanced oral cavity cancer: an analysis of patients treated with neoadjuvant cisplatin-based chemotherapy followed by surgery. (15880411)
2005
33
Postoperative radiotherapy after titanium plate mandibular reconstruction for oral cavity cancer. (16199984)
2005
34
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. (15598591)
2005
35
Salivary epidermal growth factor in oral cavity cancer. (15598585)
2005
36
Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. (16118155)
2005
37
Oral cavity cancer. (16361136)
2005
38
Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. (15792610)
2005
39
Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. (15342664)
2004
40
Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. (12915878)
2003
41
Distant metastases from lip and oral cavity cancer. (11408816)
2001
42
Tendencies in the oral cavity cancer morbidity in three regions of South Bulgaria for a period of 15 years (1985-1999). (15354492)
2001
43
Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. (10470985)
1999
44
Soluble IL-6 receptor release by PMNs and PBMC in patients with oral cavity cancer. (9581469)
1997
45
Prognostic significance of p53 protein accumulation in early stage T1 oral cavity cancer. (7950844)
1994
46
Re: Oral cavity cancer in non-users of tobacco. (8360936)
1993
47
Oral cavity cancer: 234 patients treated with radiotherapy alone with curative intent. (3076686)
1988
48
Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. (3829319)
1987
49
Functional analysis of treatment of oral cavity cancer. (3741662)
1986
50
New test series for the functional evaluation of oral cavity cancer. (4066369)
1985

Variations for Oral Cavity Cancer

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Expression for genes affiliated with Oral Cavity Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

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Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG, 55R&D Systems, 54QIAGEN, 58SinoBiological
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Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.6FADD, TNFRSF6B
29.4GPX1, GDF15
39.4TLR6, FADD
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.2FADD, TNFRSF10B
5
Show member pathways
9.2FADD, TNFRSF10B
69.2TNFRSF10B, FADD
7
Show member pathways
TRAIL signaling pathway39
9.2FADD, TNFRSF10B
8
Show member pathways
9.2TNFRSF10B, FADD
99.0TLR6, TNFRSF10B
10
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
8.8FADD, TNFRSF10B, TNFRSF6B
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.8TNFRSF10B, FADD, TNFRSF6B
12
Show member pathways
8.8FADD, TNFRSF6B, TNFRSF10B
138.6GDF15, TNFRSF10B, GPX1
14
Show member pathways
8.6FADD, TLR6, TNFRSF10B
15
Show member pathways
8.6FADD, TLR6, TNFRSF10B
168.3TNFRSF10B, GDF15, TNFRSF6B, FADD
17
Show member pathways
8.2TNFRSF10B, TNFRSF6B, FADD, TLR6

Compounds for genes affiliated with Oral Cavity Cancer

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulindac sulfide469.3TNFRSF10B, GDF15
2sulindac46 1210.1TNFRSF10B, GDF15
3sp 60012546 6210.1FADD, TNFRSF10B
4ceramide468.9FADD, TNFRSF10B, GPX1
5phosphatidylinositol468.8GDF15, TNFRSF6B, FADD
6doxorubicin46 52 1210.8GPX1, TNFRSF10B, FADD
7oxygen46 259.7FADD, TNFRSF10B, GPX1
8lipid468.1TLR6, GPX1, TNFRSF10B, FADD

GO Terms for genes affiliated with Oral Cavity Cancer

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17Gene Ontology
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Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.4FADD, TNFRSF10B
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3FADD, TNFRSF10B
3cellular response to mechanical stimulusGO:0712609.3FADD, TNFRSF10B
4toll-like receptor 4 signaling pathwayGO:0341429.3TLR6, FADD
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3TNFRSF10B, FADD
6activation of NF-kappaB-inducing kinase activityGO:0072509.2TLR6, TNFRSF10B
7apoptotic signaling pathwayGO:0971909.2FADD, TNFRSF10B
8toll-like receptor signaling pathwayGO:0022249.1FADD, TLR6
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8FADD, TNFRSF10B, TLR6
10apoptotic processGO:0069158.8FADD, TNFRSF6B, TNFRSF10B

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048728.6TNFRSF6B, TNFRSF10B, TLR6

Products for genes affiliated with Oral Cavity Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cavity Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet