MCID: ORL007
MIFTS: 50

Oral Cavity Cancer malady

Cancer category

Summaries for Oral Cavity Cancer

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A gastrointestinal system cancer that is located in the oral cavity.

MalaCards: Oral Cavity Cancer, also known as malignant neoplasm of anterior portion of floor of mouth, is related to oral cancer and leukoplakia. An important gene associated with Oral Cavity Cancer is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are ethanol degradation II and Caffeine Pathway, Pharmacokinetics. The compounds estrogen and nadph have been mentioned in the context of this disorder. Affiliated tissues include the oral cavity, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Oral Cavity Cancer

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

oral cavity cancer 8 10
malignant neoplasm of anterior portion of floor of mouth 8
malignant neoplasm of lateral portion of floor of mouth 8
malignant neoplasm of other sites of floor of mouth 8
malignant neoplasm of lateral floor of mouth 8
malignant tumor of anterior floor of mouth 8
malignant tumor of the floor of the mouth 8
malignant neoplasm of floor of mouth, nos 8
malignant tumor of lateral floor of mouth 8
malignant neoplasm of floor of mouth nos 8
malignant neoplasm of floor of mouth 8
malignant tumor of floor of mouth 8
malignant neoplasm of mouth 61


External Ids:

Disease Ontology8 DOID:8618
ICD9CM27 144, 144.9
NCIt40 C9318
ICD1025 C04, C04.0, C04.1

Related Diseases for Oral Cavity Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Cavity Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.8SOD2, CYP1A1, CYP2E1, GSTM1, GSTT1
2leukoplakia30.1GSTT1, GSTM1, CYP1A1
3hepatitis c30.1SOD2, CYP1A1, CYP2E1, IL18, GSTM1
4hepatitis b30.1CASP8, HSP90B1, SOD2, FADD, NAT2, GSTT1
5mandibular cancer10.4
6lip and oral cavity cancer10.4
7wernicke encephalopathy10.1
8hepatitis a10.1
9tracheal cancer10.1
10oral leukoplakia10.1
11lung cancer susceptibility10.1
12age related macular degeneration10.0HEPH
13prostatitis10.0GDF15
14esophagitis10.0SOD2
15dermatitis10.0IL18
16pneumoconiosis10.0CP
17skin cancer10.0CYP1A1
18acute myocardial infarction10.0GSTM1
19fatty liver disease10.0CYP2E1
20graves' disease10.0MPO
21iron deficiency anemia10.0HEPH
22cholestasis10.0CP
23neuropathy10.0SOD2
24esophageal cancer10.0ALDH2, CYP2E1
25meningioma10.0GSTT1
26myocardial infarction10.0ALDH2, GSTT1
27primary open angle glaucoma10.0GSTM1
28schistosomiasis10.0GSTM1
29lupus erythematosus10.0NAT2, IL18
30schizophrenia10.0GPX1, CP
31psoriasis10.0IL18, NAT2
32aceruloplasminemia10.0CP, HEPH
33osteoarthritis10.0IL18, TNFRSF10B
34thyroid cancer10.0GSTT1, GSTM1
35motor neuron disease10.0SOD2, GSTT1
36medulloblastoma10.0TNFRSF10B, CASP8
37asbestosis10.0GSTT1, GSTM1
38hemochromatosis10.0CP, HEPH
39periodontal disease10.0MPO
40toxic encephalopathy10.0GPX1, SOD2
41familial adenomatous polyposis10.0NAT2, TNFRSF10B
42malignant mesothelioma10.0SOD2, TNFRSF10B, NAT2
43hyperglycemia10.0GPX1, SOD2
44insulin resistance10.0IL18, CYP2E1
45myeloma10.0TNFRSF10B, CASP8, HSP90B1
46hypercholesterolemia10.0SOD2
47colon adenocarcinoma10.0TNFRSF6B, CASP8
48coronary heart disease10.0GDF15, IL18, GSTT1
49molluscum contagiosum10.0CASP8, IL18
50cataract10.0NAT2, GPX1, GSTT1

Graphical network of the top 20 diseases related to Oral Cavity Cancer:



Diseases related to oral cavity cancer

Clinical Features for Oral Cavity Cancer

Drugs & Therapeutics for Oral Cavity Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oral Cavity Cancer

Drug clinical trials:

Search ClinicalTrials for Oral Cavity Cancer

Search NIH Clinical Center for Oral Cavity Cancer

Search CenterWatch for Oral Cavity Cancer

Genetic Tests for Oral Cavity Cancer

Anatomical Context for Oral Cavity Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Oral Cavity Cancer:

14
The oral cavity

Animal Models for Oral Cavity Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Oral Cavity Cancer

Sources:
51PubMed
See all sources

Articles related to Oral Cavity Cancer:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Selective use of postoperative neck radiotherapy in oral cavity and oropharynx cancer: a prospective clinical study. (23621873)
2013
2
Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. (24064974)
2013
3
Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer. (22907805)
2013
4
A review of risk factors for oral cavity cancer: the importance of a standardized case definition. (22882534)
2013
5
Pitfalls in the staging of cancer of oral cavity cancer. (23199660)
2013
6
Outcome analyses of unusual site neck recurrence in oral cavity cancer. (22872292)
2013
7
Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction. (22565542)
2012
8
Effects of multidisciplinary care on the survival of patients with oral cavity cancer in Taiwan. (22534006)
2012
9
Impact of smoking status on clinical outcome in oral cavity cancer patients. (21996543)
2012
10
Podoplanin in the development and progression of oral cavity cancer: a preliminary study. (23285404)
2012
11
Comparison between free flap and pectoralis major pedicled flap for reconstruction in oral cavity cancer patients--a quality of life analysis. (21498107)
2011
12
Psychometric testing of the Chinese-version cancer needs questionnaire short form head and neck cancer-specific version in oral cavity cancer patients. (20422230)
2011
13
Overexpression of B cell-activating factor (BAFF) in neutrophils of oral cavity cancer patients - preliminary study. (21391737)
2011
14
Prognostic factors in oral cavity cancer with skull base recurrence. (21036497)
2011
15
Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study. (21527208)
2011
16
Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. (19585476)
2010
17
Oral cavity cancer in developed and in developing countries: population-based incidence. (19644932)
2010
18
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. (19259098)
2009
19
TLRs and Bcl-2 family proteins in neutrophils of oral cavity cancer patients. (20430729)
2009
20
Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? (18474310)
2008
21
Fluorimetric detection of aldehyde dehydrogenase activity in human tissues in diagnostic of cancers of oral cavity. (18536178)
2008
22
The release of soluble forms of TRAIL and DR5 by neutrophils of oral cavity cancer patients. (18519235)
2008
23
Intra-arterial chemoradiation for T3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. (18194553)
2008
24
Oral cavity cancer. (17893592)
2007
25
IMRT in oral cavity cancer. (17430599)
2007
26
Oxidative stress in lymphocytes, neutrophils, and serum of oral cavity cancer patients: modulatory array of L-glutamine. (17593404)
2007
27
The role of CD44 adhesion molecule in oral cavity cancer. (16837897)
2006
28
Current radiation therapy management issues in oral cavity cancer. (16580917)
2006
29
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. (15598591)
2005
30
Salivary epidermal growth factor in oral cavity cancer. (15598585)
2005
31
Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. (16118155)
2005
32
Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. (15649637)
2005
33
In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity. (15504155)
2004
34
Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. (12915878)
2003
35
Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer. (12578459)
2003
36
Evaluation of quality of life of patients with oral cavity cancer in three counties of south Bulgaria. (12943053)
2003
37
Tendencies in the oral cavity cancer morbidity in three regions of South Bulgaria for a period of 15 years (1985-1999). (15354492)
2001
38
Tobacco habits and risk of lung, oropharyngeal and oral cavity cancer: a population-based case-control study in Bhopal, India. (10922335)
2000
39
Clinical relevance of tumor ploidy and micronucleus formation for oral cavity cancer. (10587027)
1999
40
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. (10521794)
1999
41
Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. (11173639)
1997
42
A simple risk estimates study for oral cavity cancer: practical approach in Indian context. (9212572)
1997
43
Management of early oral cavity cancer. Experience of Centre Oscar Lambret. (7920170)
1994
44
Re: Oral cavity cancer in non-users of tobacco. (8360936)
1993
45
Black (air-cured) and blond (flue-cured) tobacco and cancer risk. V: Oral cavity cancer. (8343281)
1993
46
Laser resection for early oral cavity cancer. Results and complications. (3674652)
1987
47
New test series for the functional evaluation of oral cavity cancer. (4066369)
1985
48
Studies of metronidazole radiosensitizing effect in radiation treatment of patients with oral cavity cancer. (3982556)
1985
49
The use of acrylic resin oral prosthesis in radiation therapy of oral cavity and paranasal sinus cancer. (6288635)
1982
50
Oral-cutaneous stomas for oral cavity cancer. (5542352)
1971

Genetic Variations for Oral Cavity Cancer

Expression for genes affiliated with Oral Cavity Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Cavity Cancer

Search GEO for disease gene expression data for Oral Cavity Cancer.

Pathways for genes affiliated with Oral Cavity Cancer

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN, 53R&D Systems, 4Cell Signaling Technology, 60Tocris Bioscience, 56SinoBiological
See all sources

Pathways related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP2E1, ALDH2
2
Hide members
10.2NAT2, CYP2E1
310.1GSTT1, GSTM1
4
Hide members
10.1GPX1, CYP2E1, CYP1A1
5
Hide members
10.0TNFRSF10B, FADD, CASP8
6
Hide members
10.0FADD, TNFRSF10B, CASP8
7
Hide members
10.0TNFRSF10B, FADD, CASP8
810.0FADD, CASP8, TNFRSF10B
9
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.0FADD, CASP8, TNFRSF10B
10
Retinol metabolism
Hide members
10.0CYP1A1, ALDH2, CYP2E1
11
Hide members
10.0ALDH2, CYP2E1, CYP1A1
12
Hide members
10.0ALDH2, CYP2E1, CYP1A1
13
Acetaminophen metabolism
Hide members
10.0CYP1A1, NAT2, CYP2E1
14
Hide members
10.0CYP2E1, NAT2, CYP1A1
1510.0GPX1, SOD2, CYP1A1
16
Glutathione metabolism
Hide members
10.0GSTT1, GPX1, GSTM1
1710.0TLR6, TAX1BP1, TNFRSF10B
18
Hide members
10.0HSP90B1, CASP8, TLR6
1910.0GPX1, MPO, SOD2
20
Apoptosis and survival Caspase cascade
Hide members
9.9CASP8, TNFRSF6B, FADD
21
Hide members
9.9CASP8, IL18, HSP90B1
22
Hide members
9.9FADD, CASP8, TNFRSF10B, TLR6
239.9MPO, GSTM1, GSTT1
24
Hide members
9.9TNFRSF6B, FADD, TNFRSF10B, TLR6
259.9IL18, CASP8, TLR6, FADD
26
Hide members
9.8FADD, CASP8, TLR6, HSP90B1
27
Hide members
9.8TNFRSF6B, CASP8, TNFRSF10B, FADD
28
Hide members
9.8FADD, TNFRSF10B, TNFRSF6B, CASP8
29
Naphthalene metabolism
Hide members
9.8CYP1A1, CYP2E1, GSTM1, GSTT1
30
Hide members
9.7CASP8, SOD2, FADD, CYP2E1, GPX1
31
Hide members
9.7NAT2, GSTT1, GSTM1, CYP1A1, CYP2E1
32
Hide members
9.5CYP2E1, NAT2, GSTT1, GSTM1, ALDH2, CYP1A1
339.4TNFRSF10B, TNFRSF6B, CASP8, TAX1BP1, GDF15, FADD
34
Hide members
9.4HSP90B1, CASP8, TLR6, FADD, IL18, TAX1BP1

Compounds for genes affiliated with Oral Cavity Cancer

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6GDF15
2nadph45 2411.4GPX1, SOD2
3indomethacin45 60 29 1113.3GDF15
4drugs for treatment of tuberculosis5010.3NAT2, GSTM1, GSTT1
5trans,trans-muconic acid4510.3GSTT1, CYP2E1, GSTM1
6vinylchloride4510.2GSTM1, CYP2E1, ALDH2, GSTT1
7toluene4510.2ALDH2, CYP2E1, GSTM1, GSTT1
8styrene4510.2NAT2, GSTT1, GSTM1, CYP2E1
9s-phenylmercapturic acid4510.2GSTM1, CYP2E1, GSTT1
10debrisoquine4510.2CYP2E1, NAT2, GSTM1, CYP1A1
11trichloroethylene4510.2NAT2, GSTM1, GSTT1, CYP2E1
12buthionine sulfoximine4510.1SOD2, CYP2E1, CASP8, GPX1
13isoniazid50 45 1112.1GSTT1, NAT2, CYP2E1, GSTM1
148-oxo-dg4510.1GPX1, SOD2, GSTM1, GSTT1
15benzene4510.1GSTM1, NAT2, CYP2E1, GSTT1
161-hydroxypyrene4510.1GSTT1, NAT2, CYP1A1, CYP2E1, GSTM1
17acetone4510.1GSTT1, GSTM1, CYP2E1, CYP1A1
18rsai4510.1NAT2, CYP2E1, GSTM1, GSTT1, ALDH2
19mspi4510.1CYP1A1, CYP2E1, NAT2, GSTM1, GSTT1
20cyclophosphamide45 50 1112.1GSTM1, GSTT1, CYP1A1, CYP2E1, SOD2
21butadiene monoxide4510.0GSTT1, CYP2E1, GSTM1
22hydrocarbons4510.0GSTT1, CYP1A1, NAT2, GSTM1
23epoxide4510.0GSTT1, GSTM1, NAT2, CYP2E1, CYP1A1
24creatinine4510.0ALDH2, CP, GSTM1, GSTT1, CYP2E1
25butyrate4510.0SOD2
26vitamin a45 11 2412.0SOD2, CYP1A1, CYP2E1, NAT2, ALDH2, CP
271,3-butadiene4510.0CYP2E1, GSTM1, GSTT1
28alpha tocopherol459.9CYP1A1, CP, ALDH2, SOD2, GPX1, GSTM1
294-hydroxynonenal45 2410.9GPX1, GSTM1, ALDH2, CYP2E1, MPO, SOD2
30valproic acid45 50 11 2412.9CYP1A1, CP, CYP2E1, TNFRSF10B, CASP8
31malondialdehyde459.9GSTT1, SOD2, MPO, CP, GSTM1, GPX1
32gsts459.8GSTT1, GSTM1, ALDH2, GPX1, NAT2, CYP1A1
33ethanol45 50 11 2412.7IL18, GSTT1, ALDH2, HSP90B1, CYP1A1, CYP2E1
34oxaliplatin45 50 1111.7GSTT1, GSTM1, CASP8, TNFRSF10B, MPO, CYP1A1
35folate459.7ALDH2, IL18, GSTM1, CP, NAT2, SOD2
36n acetylcysteine459.7MPO, SOD2, TNFRSF10B, CASP8, CYP1A1, IL18
375fluorouracil459.7MPO, CASP8, SOD2, TNFRSF10B, FADD, GSTM1
38ascorbic acid45 2410.6GSTM1, CYP2E1, GSTT1, CP, CYP1A1, MPO
39doxorubicin45 50 1111.6CASP8, GSTT1, GSTM1, GPX1, IL18, TNFRSF10B
40oxygen45 2410.6FADD, TNFRSF10B, HSP90B1, MPO, CYP1A1, ALDH2
41betacarotene459.6SOD2, CP, CYP1A1, CYP2E1, NAT2, ALDH2
42iron45 2410.5HEPH, CP, IL18, MPO, SOD2, GPX1
43superoxide45 2410.4SOD2, HSP90B1, CASP8, MPO, CP, GPX1
44lactate459.4CYP1A1, CYP2E1, GSTM1, CP, IL18, SOD2
45cisplatin45 50 60 1112.4CASP8, SOD2, TNFRSF10B, FADD, MPO, CYP1A1
46retinoic acid45 2410.3TNFRSF10B, CYP1A1, CYP2E1, GDF15, CP, ALDH2
47cysteine459.3GSTM1, CP, ALDH2, CASP8, SOD2, IL18
48h2o2459.2CYP1A1, CYP2E1, GSTM1, CP, GPX1, IL18
49lipid459.2IL18, FADD, CYP2E1, GPX1, TNFRSF10B, SOD2
50arginine459.0ALDH2, CP, GSTM1, SOD2, GSTT1, CASP8

GO Terms for genes affiliated with Oral Cavity Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:03126510.1CASP8, FADD
2death-inducing signaling complexGO:0312649.9CASP8, FADD
3cytosolGO:0058298.9HSP90B1, CASP8, FADD, NAT2, IL18, TAX1BP1

Biological processes related to Oral Cavity Cancer according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:01026910.4SOD2, GPX1
2hydrogen peroxide biosynthetic processGO:05066510.4SOD2, CYP1A1
3activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FADD, TNFRSF10B, CASP8
5response to hyperoxiaGO:05509310.3IL18, CYP1A1, SOD2
6removal of superoxide radicalsGO:01943010.2SOD2, MPO
7positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.2CASP8, FADD, TNFRSF10B, TLR6
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.2CASP8, TNFRSF10B, FADD
9cellular response to mechanical stimulusGO:07126010.2FADD, IL18, TNFRSF10B, CASP8
10toll-like receptor signaling pathwayGO:00222410.1HSP90B1, CASP8, FADD, TLR6
11glutathione metabolic processGO:00674910.1GSTT1, SOD2, GPX1, GSTM1
12T-helper 1 type immune responseGO:04208810.1IL18, TLR6
13response to hypoxiaGO:00166610.1CYP1A1, SOD2, HSP90B1, IL18
14toll-like receptor 4 signaling pathwayGO:03414210.0FADD, CASP8, TLR6
15response to drugGO:0424939.9CYP1A1, CYP2E1, GSTT1, SOD2
16xenobiotic metabolic processGO:0068059.9CYP2E1, NAT2, ALDH2, GSTM1, GSTT1, CYP1A1
17copper ion transportGO:0068259.8HEPH, CP
18negative regulation of apoptotic processGO:0430669.7HSP90B1, TNFRSF6B, TAX1BP1, GPX1, MPO
19innate immune responseGO:0450879.6HSP90B1, CASP8, FADD, TAX1BP1, TLR6
20small molecule metabolic processGO:0442819.6NAT2, GPX1, ALDH2, GSTM1, GSTT1, CYP2E1

Molecular functions related to Oral Cavity Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.9CYP2E1, CYP1A1, HEPH
2oxygen bindingGO:0198259.7CYP2E1, CYP1A1, SOD2

Products for genes affiliated with Oral Cavity Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Cavity Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet