MCID: ORL012
MIFTS: 42

Oral Leukoplakia malady

Oral category

Summaries for Oral Leukoplakia

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33MalaCards
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MalaCards: Oral Leukoplakia, also known as leukoplakia, oral, is related to leukoplakia and squamous cell carcinoma. An important gene associated with Oral Leukoplakia is TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1), and among its related pathways are Aflatoxin B1 metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds estrogen and vinylchloride have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and liver, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Oral Leukoplakia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral


Aliases & Descriptions:

oral leukoplakia 43
leukoplakia, oral 61
leukoplakia oral 45


Related Diseases for Oral Leukoplakia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Leukoplakia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia32.0IFI27, TNC, MKI67, GSTM1, GSTT1
2squamous cell carcinoma31.1BMI1, DFFA, MKI67, DNMT3A, ERCC2, GSTM3
3oral cancer31.0IFI27, TNC, CDK2AP1, GSTM3, GSTM1, GSTT1
4basal cell carcinoma30.3S100A7, XRCC1, MKI67, ERCC2, GSTM3, GSTM1
5oral squamous cell carcinoma10.8
6lichen planus10.6
7oral lichen planus10.6
8oral mucosa leukoplakia10.5
9oral submucous fibrosis10.5
10esophageal leukoplakia10.3
11oral candidiasis10.3
12squamous cell papilloma10.3
13anal squamous cell carcinoma10.3
14dyskeratosis congenita10.2
15erythroplakia10.2
16hepatitis e10.0
17anthracosis10.0
18verrucous carcinoma10.0
19oral leukoedema10.0
20verrucous papilloma10.0
21dyskeratosis congenita, autosomal recessive 510.0
22hepatitis10.0GSTT1
23gastritis10.0TGFA
24leiomyoma10.0MKI67
25gallbladder cancer10.0PDPN
26myeloid leukemia10.0BMI1
27primary open angle glaucoma10.0GSTM1
28malignant mesothelioma10.0PDPN
29testicular cancer10.0ERCC2
30myeloma10.0IFI27
31hepatitis c10.0GSTM1
32chondrosarcoma10.0TNC
33hepatitis b10.0GSTT1, ERCC2
34endometriosis10.0GSTT1, GSTM1
35cataract10.0GSTT1, GSTM3
36skin cancer10.0S100A7, XRCC1, ERCC2
37laryngeal carcinoma10.0IFI27, MKI67, GSTT1
38sarcoma10.0GSTM1, B3GAT1, MKI67
39medulloblastoma10.0BMI1
40pituitary tumors10.0TGFA, IFI27
41cervical intraepithelial neoplasia10.0MKI67, XRCC1, IFI27
42ductal carcinoma in situ10.0PDPN, S100A7
43asbestosis10.0GSTM1, GSTT1
44rheumatoid arthritis10.0GSTT1, B3GAT1
45thyroid cancer10.0TNC, GSTM1, GSTT1
46oligodendroglioma10.0GSTT1, ERCC2, MKI67
47psoriasis10.0S100A7, TGFA
48brain cancer10.0GSTT1, GSTM1
49myelodysplastic syndromes10.0BMI1, GSTM1, GSTT1
50pancreatic cancer10.0TGFA, TNC, XRCC1, IFI27

Graphical network of the top 20 diseases related to Oral Leukoplakia:



Diseases related to oral leukoplakia

Clinical Features for Oral Leukoplakia

Drugs & Therapeutics for Oral Leukoplakia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Leukoplakia

Drug clinical trials:

Search ClinicalTrials for Oral Leukoplakia

Search NIH Clinical Center for Oral Leukoplakia

Search CenterWatch for Oral Leukoplakia

Genetic Tests for Oral Leukoplakia

Anatomical Context for Oral Leukoplakia

Sources:
33MalaCards
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MalaCards organs/tissues related to Oral Leukoplakia:

33
Bone marrow, Whole blood, Liver, Breast, Myeloid, T cells, Endothelial, Tongue

Animal Models for Oral Leukoplakia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Oral Leukoplakia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.8GSTM1, ERCC2, B3GAT1, DNMT3A, DFFA, BMI1

Publications for Oral Leukoplakia

Sources:
51PubMed
See all sources

Articles related to Oral Leukoplakia:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Oral hairy leukoplakia diagnosis by Epstein-Barr virus inA situ hybridization in liquid-based cytology. (23445399)
2014
2
Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis? (24403051)
2014
3
Oral hairy leukoplakia. (24428034)
2013
4
Immunohistochemical analysis of syndecan-1 in leukoplakia and oral submucous fibrosis. (24019799)
2013
5
Malignant transformation of oral leukoplakia in a well-defined cohort of 144 patients. (23521625)
2013
6
Individualized diagnosis versus epidemiological assessment of oral leukoplakia. (23265942)
2013
7
Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral precancerous lesion-leukoplakia. (23248463)
2012
8
Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa. (22665749)
2012
9
Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia. (22719913)
2012
10
Leukoplakia and erythroplakia of the oral mucosa--a brief overview. (23957095)
2012
11
Midkine expression in oral squamous cell carcinoma and leukoplakia. (21595751)
2012
12
Prognostic value of DNA ploidy status in patients with oral leukoplakia. (21880540)
2011
13
Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis. (21523324)
2011
14
Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma. (21466259)
2011
15
Oral hairy leukoplakia. (22128498)
2011
16
Cotton-swab cryotherapy for oral leukoplakia. (19283844)
2009
17
Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. (18990760)
2008
18
Matrix metalloproteinase-2 matrix metalloproteinase-9 and inducible nitric oxide synthase in oral leukoplakia: immunohistochemistry and RT-PCR analysis. (18597705)
2008
19
Oral hairy leukoplakia arising in an oral lichen planus lesion in an otherwise immune-competent patient. (17892032)
2007
20
Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. (18240892)
2007
21
Prevalence of oral hairy leukoplakia in 120 pediatric patients infected with HIV-1. (16878201)
2006
22
Interventions for treating oral leukoplakia. (17054142)
2006
23
Discusson of adjunctive diagnostic modalities available for screening of oral leukoplakia. (16776425)
2006
24
Oral lycopene--an efficacious treatment for oral leukoplakia? (15789046)
2005
25
Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy. (16037967)
2005
26
Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia. (15216478)
2004
27
Secondary syphilis simulating oral hairy leukoplakia. (14512934)
2003
28
Tobacco usage in relation to the anatomical site of oral leukoplakia. (11354917)
2001
29
Oral leukoplakia: open trial of topical therapy with calcipotriol compared with tretinoin. (11720042)
2001
30
Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. (10760727)
2000
31
Single-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia. (10667462)
2000
32
Expression of apoptotic signaling proteins in leukoplakia and oral lichen planus: quantitative and topographical studies. (10972347)
2000
33
Oral hairy leukoplakia: an Epstein-Barr virus-associated disease of patients with HIV. (11708168)
2000
34
Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial. (10604407)
1999
35
Oral hairy leukoplakia in HIV-positive patients. (9486697)
1998
36
Flow cytometric analysis of nuclear DNA content in oral leukoplakia. (9597283)
1998
37
Oral hairy leukoplakia with ultrastructural evidence of Merkel-like cells in human tongue epithelium. (9567451)
1998
38
Flow cytometric analysis of cell cycle fractions in oral leukoplakia. (9662018)
1998
39
Loss of p53 gene as a biomarker of high risk oral leukoplakias. (9425746)
1997
40
Candida biotypes in patients with oral leukoplakia and lichen planus. Candida biotypes in leukoplakia and lichen planus. (8981773)
1996
41
Smokeless tobacco and oral leukoplakia. (8967889)
1996
42
Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia. (8827356)
1996
43
A proposal for a classification and staging system for oral leukoplakia: a preliminary study. (8746271)
1995
44
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. (8275193)
1993
45
Oral leukoplakia, with emphasis on malignant transformation. A follow-up study of 46 patients. (2651483)
1989
46
Oral leukoplakia: prevalence of dysplastic and carcinomatous change in verruciform and planar patterns. (6949647)
1981
47
Association between oral leukoplakia and sex, age, and tobacco habits. (4538900)
1972
48
Yttrium 90 in the treatment of oral leukoplakia. (4509979)
1972
49
Exfoliative cytologic changes in oral leukoplakia. (5252094)
1969
50
MYCOTIC INFECTION IN ORAL LEUKOPLAKIA. (14321739)
1965

Genetic Variations for Oral Leukoplakia

Expression for genes affiliated with Oral Leukoplakia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Leukoplakia

Search GEO for disease gene expression data for Oral Leukoplakia.

Pathways for genes affiliated with Oral Leukoplakia

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Oral Leukoplakia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3GSTT1, GSTM1
210.3GSTT1, GSTM1
3
Glutathione metabolism
Hide members
10.3GSTT1, GSTM1, GSTM3
410.3TNC, BMI1, DNMT3A
510.1ERCC2, GSTM3, GSTM1, GSTT1, B3GAT1
610.1WNT3, MIR31, DNMT3A, BMI1, TNC

Compounds for genes affiliated with Oral Leukoplakia

Sources:
45Novoseek, 50PharmGKB, 24HMDB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Oral Leukoplakia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8S100A7
2vinylchloride4510.7GSTM1, GSTT1, XRCC1
3diepoxybutane4510.7XRCC1, GSTM1, GSTT1
4drugs for treatment of tuberculosis5010.7GSTM1, GSTT1
5n-(2-hydroxyethyl)valine4510.7GSTM1, GSTT1
6noradrenochrome45 2411.7GSTT1, GSTM3, GSTM1
7hydrochloric acid45 2411.7GSTM1, GSTM3, GSTT1
8methylchloride4510.7GSTM1, GSTT1
9adrenochrome45 2411.7GSTM3, GSTM1, GSTT1
108-oxoguanine4510.7XRCC1, GSTT1, GSTM1
11benzene4510.7XRCC1, GSTM1, GSTT1
12gsts4510.6GSTT1, GSTM1, GSTM3, XRCC1
13cotinine45 2411.6XRCC1, ERCC2, GSTT1, GSTM1
14trans,trans-muconic acid4510.6GSTM1, GSTT1
15epoxide4510.6XRCC1, GSTM3, GSTT1, GSTM1
16mspi4510.6GSTT1, GSTM1, XRCC1, ERCC2
17hydrocarbons4510.6ERCC2, GSTT1, GSTM1
18platinum45 5011.6GSTT1, ERCC2, XRCC1
19acetone4510.6GSTM1, GSTT1, MKI67
20rsai4510.6GSTT1, TGFA, GSTM1
21chi 24510.6GSTT1, IFI27, GSTM1, MKI67
22s-phenylmercapturic acid4510.6GSTT1, GSTM1
23hema4510.6GSTM1, GSTT1
242-naphthol4510.6GSTM1, GSTT1
25oxaliplatin45 50 1112.6GSTM1, TGFA, XRCC1, ERCC2, GSTT1
26Glutathione11 2411.6GSTM3, GSTM1, GSTT1
27ethylene oxide4510.5GSTM1, GSTT1
28ascorbic acid45 2411.5GSTT1, TGFA, XRCC1, TNC, GSTM1
29thymidylate4510.5GSTM1, ERCC2, MKI67, XRCC1, IFI27
30styrene oxide4510.5GSTT1, GSTM1
31cyclophosphamide45 50 1112.5MKI67, XRCC1, GSTM3, GSTT1, GSTM1, ERCC2
325fluorouracil4510.5TGFA, GSTM1, ERCC2, MKI67, XRCC1
33p0034510.5IFI27, MKI67, GSTM1, GSTT1, XRCC1, TNC
34p0024510.5IFI27, XRCC1, TNC, MKI67, GSTT1, GSTM1
35formaldehyde45 2411.5MKI67, GSTT1, TGFA, TNC
36benzo(a)pyrene4510.4GSTM1, XRCC1, GSTT1
37butadiene monoxide4510.4GSTT1, GSTM1
38folate4510.4GSTT1, MKI67, TGFA, XRCC1, GSTM1, ERCC2
39doxorubicin45 50 1112.4GSTM1, IFI27, TGFA, GSTT1, MKI67
40polyvinyl chloride4510.4GSTT1, XRCC1
41arginine4510.3TGFA, GSTM1, GSTT1, IFI27, XRCC1, MKI67
42cisplatin45 50 60 1113.3MKI67, DFFA, GSTT1, GSTM3, IFI27, ERCC2
43paraffin4510.3IFI27, PDPN, TNC, MKI67, TGFA
44oligonucleotide4510.3GSTT1, TGFA, IFI27, XRCC1, DNMT3A, TNC
45oxygen45 2411.3GSTT1, GSTM1, IFI27, S100A7, DFFA, GSTM3
46vegf4510.3ERCC2, MKI67, DFFA, PDPN, IFI27, TGFA
47methotrexate45 50 1112.3GSTM1, ERCC2, TGFA, MKI67
48cumene hydroperoxide4510.2GSTT1, GSTM1
49creatinine4510.2TGFA, GSTT1, GSTM1, XRCC1
501,3-butadiene4510.0GSTM1, GSTT1

GO Terms for genes affiliated with Oral Leukoplakia

Sources:
16Gene Ontology
See all sources

Biological processes related to Oral Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.4GSTM1, GSTM3
2glutathione derivative biosynthetic processGO:190168710.4GSTT1, GSTM1, GSTM3
3cellular detoxification of nitrogen compoundGO:07045810.3GSTM1, GSTM3
4glutathione metabolic processGO:00674910.2GSTM3, GSTM1, GSTT1
5cell proliferationGO:00828310.1TGFA, ERCC2, MKI67, PDPN
6xenobiotic catabolic processGO:04217810.0GSTM1, GSTM3

Molecular functions related to Oral Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:04329510.3GSTM1, GSTM3
2glutathione transferase activityGO:00436410.0GSTT1, GSTM1, GSTM3

Products for genes affiliated with Oral Leukoplakia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Leukoplakia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet