MCID: ORL012
MIFTS: 31

Oral Leukoplakia malady

Oral diseases category

Summaries for Oral Leukoplakia

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32MalaCards
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MalaCards: Oral Leukoplakia, also known as leukoplakia, oral, is related to squamous cell carcinoma and basal cell carcinoma. An important gene associated with Oral Leukoplakia is TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1), and among its related pathways are Aflatoxin B1 metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds estrogen and vinylchloride have been mentioned in the context of this disorder. Related mouse phenotype behavior/neurological.

Aliases & Classifications for Oral Leukoplakia

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

oral leukoplakia 42
leukoplakia, oral 60
leukoplakia oral 44


Related Diseases for Oral Leukoplakia

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17GeneCards, 18GeneDecks
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Diseases related to Oral Leukoplakia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.1BMI1, DFFA, MKI67, DNMT3A, ERCC2, GSTM3
2basal cell carcinoma30.2S100A7, XRCC1, MKI67, ERCC2, GSTM3, GSTM1
3hepatitis30.0GSTT1
4hepatitis c30.0GSTM1
5breast cancer30.0IFI27, TNC, WNT3, TGFA
6lichen planus10.6
7oral submucous fibrosis10.5
8oral mucosa leukoplakia10.4
9esophageal leukoplakia10.3
10oral candidiasis10.3
11esophagitis10.3
12esophageal cancer10.3
13papilloma10.3
14squamous cell papilloma10.2
15dyskeratosis congenita10.2
16periodontitis10.2
17barrett's esophagus10.0
18anthracosis10.0
19verrucous carcinoma10.0
20oral leukoedema10.0
21verrucous papilloma10.0
22diabetes mellitus10.0
23food allergy10.0
24in situ carcinoma10.0
25laryngitis10.0
26stomatitis10.0
27dyskeratosis congenita, autosomal recessive 510.0
28gastritis10.0TGFA
29leiomyoma10.0MKI67
30gallbladder cancer10.0PDPN
31myeloid leukemia10.0BMI1
32primary open angle glaucoma10.0GSTM1
33malignant mesothelioma10.0PDPN
34testicular cancer10.0ERCC2
35myeloma10.0IFI27
36chondrosarcoma10.0TNC
37hepatitis b10.0GSTT1, ERCC2
38endometriosis10.0GSTT1, GSTM1
39cataract10.0GSTT1, GSTM3
40laryngeal benign neoplasm10.0IFI27, MKI67, GSTT1
41sarcoma10.0GSTM1, B3GAT1, MKI67
42medulloblastoma10.0BMI1
43pituitary tumors10.0TGFA, IFI27
44cervical intraepithelial neoplasia10.0MKI67, XRCC1, IFI27
45ductal carcinoma in situ10.0PDPN, S100A7
46asbestosis10.0GSTM1, GSTT1
47rheumatoid arthritis10.0GSTT1, B3GAT1
48thyroid cancer10.0TNC, GSTM1, GSTT1
49oligodendroglioma10.0GSTT1, ERCC2, MKI67
50psoriasis10.0S100A7, TGFA

Graphical network of the top 20 diseases related to Oral Leukoplakia:



Diseases related to oral leukoplakia

Clinical Features for Oral Leukoplakia

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Drugs & Therapeutics for Oral Leukoplakia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Oral Leukoplakia

Drug clinical trials:

Search ClinicalTrials for Oral Leukoplakia

Search NIH Clinical Center for Oral Leukoplakia

Search CenterWatch for Oral Leukoplakia

Genetic Tests for Oral Leukoplakia

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Anatomical Context for Oral Leukoplakia

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Animal Models for Oral Leukoplakia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Oral Leukoplakia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.8GSTM1, ERCC2, B3GAT1, DNMT3A, DFFA, BMI1

Publications for Oral Leukoplakia

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Genetic Variations for Oral Leukoplakia

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Expression for genes affiliated with Oral Leukoplakia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Leukoplakia

Search GEO for disease gene expression data for Oral Leukoplakia.

Pathways for genes affiliated with Oral Leukoplakia

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Oral Leukoplakia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3GSTT1, GSTM1
210.3GSTT1, GSTM1
3
Glutathione metabolism
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10.3GSTT1, GSTM1, GSTM3
410.3TNC, BMI1, DNMT3A
510.1ERCC2, GSTM3, GSTM1, GSTT1, B3GAT1
610.1WNT3, MIR31, DNMT3A, BMI1, TNC

Compounds for genes affiliated with Oral Leukoplakia

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Sources:
44Novoseek, 49PharmGKB, 24HMDB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Oral Leukoplakia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8S100A7
2vinylchloride4410.7GSTM1, GSTT1, XRCC1
3diepoxybutane4410.7XRCC1, GSTM1, GSTT1
4drugs for treatment of tuberculosis4910.7GSTM1, GSTT1
5n-(2-hydroxyethyl)valine4410.7GSTM1, GSTT1
6noradrenochrome44 2411.7GSTT1, GSTM3, GSTM1
7hydrochloric acid44 2411.7GSTM1, GSTM3, GSTT1
8methylchloride4410.7GSTM1, GSTT1
9adrenochrome44 2411.7GSTM3, GSTM1, GSTT1
108-oxoguanine4410.7XRCC1, GSTT1, GSTM1
11benzene4410.7XRCC1, GSTM1, GSTT1
12gsts4410.6GSTT1, GSTM1, GSTM3, XRCC1
13cotinine44 2411.6XRCC1, ERCC2, GSTT1, GSTM1
14trans,trans-muconic acid4410.6GSTM1, GSTT1
15epoxide4410.6XRCC1, GSTM3, GSTT1, GSTM1
16mspi4410.6GSTT1, GSTM1, XRCC1, ERCC2
17hydrocarbons4410.6ERCC2, GSTT1, GSTM1
18platinum44 4911.6GSTT1, ERCC2, XRCC1
19acetone4410.6GSTM1, GSTT1, MKI67
20rsai4410.6GSTT1, TGFA, GSTM1
21chi 24410.6GSTT1, IFI27, GSTM1, MKI67
22s-phenylmercapturic acid4410.6GSTT1, GSTM1
23hema4410.6GSTM1, GSTT1
242-naphthol4410.6GSTM1, GSTT1
25oxaliplatin44 49 1112.6GSTM1, TGFA, XRCC1, ERCC2, GSTT1
26Glutathione11 2411.6GSTM3, GSTM1, GSTT1
27ethylene oxide4410.5GSTM1, GSTT1
28ascorbic acid44 2411.5GSTT1, TGFA, XRCC1, TNC, GSTM1
29thymidylate4410.5GSTM1, ERCC2, MKI67, XRCC1, IFI27
30styrene oxide4410.5GSTT1, GSTM1
31cyclophosphamide44 49 1112.5MKI67, XRCC1, GSTM3, GSTT1, GSTM1, ERCC2
325fluorouracil4410.5TGFA, GSTM1, ERCC2, MKI67, XRCC1
33p0034410.5IFI27, MKI67, GSTM1, GSTT1, XRCC1, TNC
34p0024410.5IFI27, XRCC1, TNC, MKI67, GSTT1, GSTM1
35formaldehyde44 2411.5MKI67, GSTT1, TGFA, TNC
36benzo(a)pyrene4410.4GSTM1, XRCC1, GSTT1
37butadiene monoxide4410.4GSTT1, GSTM1
38folate4410.4GSTT1, MKI67, TGFA, XRCC1, GSTM1, ERCC2
39doxorubicin44 49 1112.4GSTM1, IFI27, TGFA, GSTT1, MKI67
40polyvinyl chloride4410.4GSTT1, XRCC1
41arginine4410.3TGFA, GSTM1, GSTT1, IFI27, XRCC1, MKI67
42cisplatin44 49 59 1113.3MKI67, DFFA, GSTT1, GSTM3, IFI27, ERCC2
43paraffin4410.3IFI27, PDPN, TNC, MKI67, TGFA
44oligonucleotide4410.3GSTT1, TGFA, IFI27, XRCC1, DNMT3A, TNC
45oxygen44 2411.3GSTT1, GSTM1, IFI27, S100A7, DFFA, GSTM3
46vegf4410.3ERCC2, MKI67, DFFA, PDPN, IFI27, TGFA
47methotrexate44 49 1112.3GSTM1, ERCC2, TGFA, MKI67
48cumene hydroperoxide4410.2GSTT1, GSTM1
49creatinine4410.2TGFA, GSTT1, GSTM1, XRCC1
501,3-butadiene4410.0GSTM1, GSTT1

GO Terms for genes affiliated with Oral Leukoplakia

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16Gene Ontology
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Biological processes related to Oral Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.4GSTM1, GSTM3
2glutathione derivative biosynthetic processGO:190168710.4GSTT1, GSTM1, GSTM3
3cellular detoxification of nitrogen compoundGO:07045810.3GSTM1, GSTM3
4glutathione metabolic processGO:00674910.2GSTM3, GSTM1, GSTT1
5cell proliferationGO:00828310.1TGFA, ERCC2, MKI67, PDPN
6xenobiotic catabolic processGO:04217810.0GSTM1, GSTM3

Molecular functions related to Oral Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:04329510.3GSTM1, GSTM3
2glutathione transferase activityGO:00436410.0GSTT1, GSTM1, GSTM3

Products for genes affiliated with Oral Leukoplakia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Leukoplakia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet