MCID: ORL012
MIFTS: 29

Oral Leukoplakia malady

Rare diseases, Oral diseases categories

Summaries for Oral Leukoplakia

About this section


MalaCards based summary: Oral Leukoplakia, also known as leukoplakia, oral, is related to leukoplakia and oral cancer. An important gene associated with Oral Leukoplakia is TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1), and among its related pathways is Cytoskeleton remodeling Keratin filaments. The compounds gsts and epoxide have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and tongue.

Aliases & Classifications for Oral Leukoplakia

About this section
Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Oral Leukoplakia, Aliases & Descriptions:

Name: Oral Leukoplakia 41
Leukoplakia, Oral 60
 
Leukoplakia Oral 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Related Diseases for Oral Leukoplakia

About this section

Diseases related to Oral Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia32.6KRT13
2oral cancer30.9GSTM3, KRT13
3white sponge nevus 130.4KRT4, KRT13
4basal cell carcinoma30.3XRCC1, GSTM3
5breast cancer29.3BMI1, XRCC1, FADD, GSTM3, TP53AIP1
6oral squamous cell carcinoma10.8
7lichen planus10.6
8oral hairy leukoplakia10.5
9oral submucous fibrosis10.5
10oral lichen planus10.5
11oral candidiasis10.4
12esophagitis10.4
13papilloma10.4
14esophageal cancer10.3
15pachyonychia congenita 110.2
16dyskeratosis congenita10.2
17periodontitis10.2
18erythroplakia10.2
19laryngeal carcinoma10.2GSTM3, XRCC1
20squamous cell carcinoma, head and neck10.1GSTM3, XRCC1
21hepatitis c virus10.1
22dyskeratosis, hereditary benign intraepithelial10.1
23pachyonychia congenita 310.1
24pachyonychia congenita 410.1
25revesz syndrome10.1
26cerebroretinal microangiopathy with calcifications and cysts10.1
27pachyonychia congenita 210.1
28dyskeratosis congenita, x-linked10.1
29keratitis-ichthyosis-deafness syndrome10.1
30dyskeratosis congenita, autosomal dominant 110.1
31dyskeratosis congenita, autosomal dominant 310.1
32dyskeratosis congenita, autosomal recessive 110.1
33dyskeratosis congenita, autosomal recessive 510.1
34hematopoietic stem cell transplantation10.1
35hepatitis10.1
36hepatitis c10.1
37anthracosis10.1
38oral mucosa leukoplakia10.1
39verrucous carcinoma10.1
40food allergy10.1
41laryngitis10.1
42stomatitis10.1
43blindness10.1
44nasopharyngeal carcinoma10.1KRT13, XRCC1
45bladder cancer, somatic9.8FADD, XRCC1, GSTM3
46hematologic cancer9.8BMI1, FADD
47adenoma9.8XRCC1, B3GAT1, KRT13, KRT4
48malignant glioma9.7FADD, GSTM3, XRCC1
49lung cancer9.6FADD, XRCC1, KRT13, GSTM3
50adenocarcinoma9.6KRT13, KRT4, XRCC1, FADD

Graphical network of the top 20 diseases related to Oral Leukoplakia:



Diseases related to oral leukoplakia

Symptoms for Oral Leukoplakia

About this section

Drugs & Therapeutics for Oral Leukoplakia

About this section

Drug clinical trials:

Search ClinicalTrials for Oral Leukoplakia

Search NIH Clinical Center for Oral Leukoplakia

Genetic Tests for Oral Leukoplakia

About this section

Anatomical Context for Oral Leukoplakia

About this section

MalaCards organs/tissues related to Oral Leukoplakia:

31
Liver, Testes, Tongue, Colon, Breast, T cells

Animal Models for Oral Leukoplakia or affiliated genes

About this section

Publications for Oral Leukoplakia

About this section

Articles related to Oral Leukoplakia:

(show top 50)    (show all 435)
idTitleAuthorsYear
1
Oral leukoplakia - an update. (25553134)
2014
2
A study of salivary lactate dehydrogenase isoenzyme levels in patients with oral leukoplakia and squamous cell carcinoma by gel electrophoresis method. (25364177)
2014
3
Oral leukoplakia: what is it, what causes it and does it lead to cancer? (24379335)
2014
4
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia. (23492901)
2013
5
Candidal infection in oral leukoplakia: a clinicopathologic study of 396 patients from eastern China. (22683201)
2013
6
Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia. (22782852)
2013
7
Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma. (22170235)
2013
8
Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: the risk of oral leukoplakia. (23396292)
2013
9
Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia. (22623931)
2012
10
Diagnostic reliability of fine needle aspiration cytology against histopathology for the diagnosis of oral squamous cell carcinoma and oral leukoplakia. (23151707)
2012
11
Stromal myofibroblasts in oral leukoplakia and oral squamous cell carcinoma. (22322518)
2012
12
Prognostic value of DNA ploidy status in patients with oral leukoplakia. (21880540)
2011
13
Treatment of oral leukoplakia with carbon dioxide and potassium-titanyl-phosphate lasers: a comparison. (20171477)
2010
14
Changes in peripheral blood lymphocyte phenotypes distribution in patients with oral cancer/oral leukoplakia in Taiwan. (20605406)
2010
15
Expression of integrin-linked kinase in oral leukoplakia and early invasive carcinoma]. (20450685)
2010
16
Human papillomavirus in oral leukoplakia is no prognostic indicator of malignant transformation. (19679058)
2009
17
Gene expression analysis by oligonucleotide microarray in oral leukoplakia. (19220711)
2009
18
Genomic instability and tumor-specific DNA alterations in oral leukoplakias. (19583749)
2009
19
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer. (18251940)
2008
20
DNA cytometry of oral leukoplakia and oral lichen planus. (16505806)
2006
21
GSTM1 polymorphism and oral leukoplakia. (16519766)
2006
22
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
23
Oral lycopene--an efficacious treatment for oral leukoplakia? (15789046)
2005
24
The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. (15598583)
2005
25
Epidemiological and clinicopathological study of oral leukoplakia. (16394403)
2005
26
Influence of cigarette filters on the risk of developing oral leukoplakia in a Kenyan population. (11355433)
2001
27
Tobacco use and oral leukoplakia. (11336117)
2001
28
Oral leukoplakia status six weeks after cessation of smokeless tobacco use. (10422398)
1999
29
Viadent usage and oral leukoplakia: a spurious association. (10620468)
1999
30
Cytomorphometric analysis of squames obtained from normal oral mucosa and lesions of oral leukoplakia and squamous cell carcinoma. (9526735)
1998
31
Flow cytometric analysis of nuclear DNA content in oral leukoplakia. (9597283)
1998
32
Candida biotypes in patients with oral leukoplakia and lichen planus. Candida biotypes in leukoplakia and lichen planus. (8981773)
1996
33
Smokeless tobacco and oral leukoplakia. (8967889)
1996
34
Use of computer-assisted image analysis for noninvasive evaluation of oral lichenoid reactions and oral leukoplakia. (7614184)
1995
35
A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. (7800378)
1994
36
Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. (8416256)
1993
37
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. (8275193)
1993
38
Oral leukoplakia, with emphasis on malignant transformation. A follow-up study of 46 patients. (2651483)
1989
39
Evaluation of Langerhans cells and T cell subsets in oral lichen planus, in comparison with oral leukoplakia. (3267121)
1988
40
Epidemiologic study of the association between alcohol habits and oral leukoplakia. (6583042)
1984
41
Oral leukoplakia and cryotherapy. (6578814)
1983
42
Scanning electron microscopic study of oral leukoplakia. (6776248)
1980
43
A clinicopathologic study of oral leukoplakia with emphasis on the keratinization pattern. (374098)
1979
44
Esophageal cancer, hyperkeratosis, and oral leukoplakia: follow-up family study. (135097)
1976
45
Comparative cytologic and histologic studies in oral leukoplakia. (1066934)
1976
46
Oral leukoplakia. (940079)
1976
47
Histochemistry of the keratohyalin granules in human oral leukoplakia. (51923)
1975
48
Oral leukoplakia. (4744419)
1973
49
Clinical and histologic study of oral leukoplakia in relation to habits. A five-year follow-up. (5257182)
1969
50
A clinical and histopathologic study of oral leukoplakia. (13750550)
1961

Variations for Oral Leukoplakia

About this section

Expression for genes affiliated with Oral Leukoplakia

About this section
Search GEO for disease gene expression data for Oral Leukoplakia.

Pathways for genes affiliated with Oral Leukoplakia

About this section

Pathways related to Oral Leukoplakia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRT13, KRT4

Compounds for genes affiliated with Oral Leukoplakia

About this section

Compounds related to Oral Leukoplakia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1gsts439.6GSTM3, XRCC1
2epoxide439.5GSTM3, XRCC1
3camptothecin43 59 1211.2XRCC1, FADD
4cisplatin43 49 59 1211.5GSTM3, XRCC1, FADD

GO Terms for genes affiliated with Oral Leukoplakia

About this section

Cellular components related to Oral Leukoplakia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.5KRT13, KRT4

Products for genes affiliated with Oral Leukoplakia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Oral Leukoplakia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet