MCID: ORL012
MIFTS: 33

Oral Leukoplakia malady

Rare diseases, Oral diseases categories

Summaries for Oral Leukoplakia

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34MalaCards
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MalaCards: Oral Leukoplakia, also known as leukoplakia, oral, is related to leukoplakia and oral cancer. An important gene associated with Oral Leukoplakia is TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1), and among its related pathways is Cytoskeleton remodeling Keratin filaments. The compounds gsts and epoxide have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and tongue.

Aliases & Classifications for Oral Leukoplakia

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44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral leukoplakia 44
leukoplakia, oral 63
leukoplakia oral 46


Related Diseases for Oral Leukoplakia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Oral Leukoplakia:



Diseases related to oral leukoplakia

Symptoms for Oral Leukoplakia

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Drugs & Therapeutics for Oral Leukoplakia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Oral Leukoplakia

Drug clinical trials:

Search ClinicalTrials for Oral Leukoplakia

Search NIH Clinical Center for Oral Leukoplakia

Search CenterWatch for Oral Leukoplakia

Genetic Tests for Oral Leukoplakia

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Anatomical Context for Oral Leukoplakia

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34MalaCards
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MalaCards organs/tissues related to Oral Leukoplakia:

34
Liver, Testes, Tongue, Breast, T cells

Animal Models for Oral Leukoplakia or affiliated genes

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Publications for Oral Leukoplakia

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53PubMed
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Articles related to Oral Leukoplakia:

(show top 50)    (show all 402)
idTitleAuthorsYear
1
Oral leukoplakia: what is it, what causes it and does it lead to cancer? (24379335)
2014
2
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia. (23492901)
2013
3
Candidal infection in oral leukoplakia: a clinicopathologic study of 396 patients from eastern China. (22683201)
2013
4
Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia. (22782852)
2013
5
Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma. (22170235)
2013
6
Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: the risk of oral leukoplakia. (23396292)
2013
7
Plasma zinc antioxidant vitamins, glutathione levels and total antioxidant activity in oral leukoplakia. (22623931)
2012
8
Diagnostic reliability of fine needle aspiration cytology against histopathology for the diagnosis of oral squamous cell carcinoma and oral leukoplakia. (23151707)
2012
9
Stromal myofibroblasts in oral leukoplakia and oral squamous cell carcinoma. (22322518)
2012
10
Prognostic value of DNA ploidy status in patients with oral leukoplakia. (21880540)
2011
11
Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia. (22106236)
2011
12
Treatment of oral leukoplakia with carbon dioxide and potassium-titanyl-phosphate lasers: a comparison. (20171477)
2010
13
Changes in peripheral blood lymphocyte phenotypes distribution in patients with oral cancer/oral leukoplakia in Taiwan. (20605406)
2010
14
Expression of integrin-linked kinase in oral leukoplakia and early invasive carcinoma]. (20450685)
2010
15
Human papillomavirus in oral leukoplakia is no prognostic indicator of malignant transformation. (19679058)
2009
16
Gene expression analysis by oligonucleotide microarray in oral leukoplakia. (19220711)
2009
17
Genomic instability and tumor-specific DNA alterations in oral leukoplakias. (19583749)
2009
18
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer. (18251940)
2008
19
A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia. (17936673)
2008
20
DNA cytometry of oral leukoplakia and oral lichen planus. (16505806)
2006
21
GSTM1 polymorphism and oral leukoplakia. (16519766)
2006
22
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
23
Oral lycopene--an efficacious treatment for oral leukoplakia? (15789046)
2005
24
The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. (15598583)
2005
25
Epidemiological and clinicopathological study of oral leukoplakia. (16394403)
2005
26
Influence of cigarette filters on the risk of developing oral leukoplakia in a Kenyan population. (11355433)
2001
27
Tobacco use and oral leukoplakia. (11336117)
2001
28
Oral leukoplakia status six weeks after cessation of smokeless tobacco use. (10422398)
1999
29
Viadent usage and oral leukoplakia: a spurious association. (10620468)
1999
30
Cytomorphometric analysis of squames obtained from normal oral mucosa and lesions of oral leukoplakia and squamous cell carcinoma. (9526735)
1998
31
Flow cytometric analysis of nuclear DNA content in oral leukoplakia. (9597283)
1998
32
Candida biotypes in patients with oral leukoplakia and lichen planus. Candida biotypes in leukoplakia and lichen planus. (8981773)
1996
33
Smokeless tobacco and oral leukoplakia. (8967889)
1996
34
Use of computer-assisted image analysis for noninvasive evaluation of oral lichenoid reactions and oral leukoplakia. (7614184)
1995
35
A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. (7800378)
1994
36
Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. (8416256)
1993
37
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. (8275193)
1993
38
Oral leukoplakia, with emphasis on malignant transformation. A follow-up study of 46 patients. (2651483)
1989
39
Evaluation of Langerhans cells and T cell subsets in oral lichen planus, in comparison with oral leukoplakia. (3267121)
1988
40
Epidemiologic study of the association between alcohol habits and oral leukoplakia. (6583042)
1984
41
Oral leukoplakia and cryotherapy. (6578814)
1983
42
Scanning electron microscopic study of oral leukoplakia. (6776248)
1980
43
A clinicopathologic study of oral leukoplakia with emphasis on the keratinization pattern. (374098)
1979
44
Esophageal cancer, hyperkeratosis, and oral leukoplakia: follow-up family study. (135097)
1976
45
Comparative cytologic and histologic studies in oral leukoplakia. (1066934)
1976
46
Oral leukoplakia. (940079)
1976
47
Histochemistry of the keratohyalin granules in human oral leukoplakia. (51923)
1975
48
Oral leukoplakia. (4744419)
1973
49
Clinical and histologic study of oral leukoplakia in relation to habits. A five-year follow-up. (5257182)
1969
50
A clinical and histopathologic study of oral leukoplakia. (13750550)
1961

Variations for Oral Leukoplakia

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Expression for genes affiliated with Oral Leukoplakia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Leukoplakia

Search GEO for disease gene expression data for Oral Leukoplakia.

Pathways for genes affiliated with Oral Leukoplakia

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51PathCards, 61Thomson Reuters
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Pathways related to Oral Leukoplakia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRT13, KRT4

Compounds for genes affiliated with Oral Leukoplakia

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB
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Compounds related to Oral Leukoplakia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gsts469.6GSTM3, XRCC1
2epoxide469.5GSTM3, XRCC1
3camptothecin46 62 1211.2XRCC1, FADD
4cisplatin46 52 62 1211.5GSTM3, XRCC1, FADD

GO Terms for genes affiliated with Oral Leukoplakia

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17Gene Ontology
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Cellular components related to Oral Leukoplakia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT13, KRT4

Products for genes affiliated with Oral Leukoplakia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Leukoplakia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet