MCID: ORL012
MIFTS: 45

Oral Leukoplakia

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Oral Leukoplakia

MalaCards integrated aliases for Oral Leukoplakia:

Name: Oral Leukoplakia 49 28
Leukoplakia, Oral 69
Leukoplakia Oral 51

Classifications:



External Ids:

UMLS 69 C0023532

Summaries for Oral Leukoplakia

NIH Rare Diseases : 49 Oral leukoplakia describes a white plaque that does not rub off and cannot be characterized as any other condition. Though it may occur in any part of the mouth, it generally affects the tongue, gums, and inner cheek. Physicians will usually biopsy oral leukoplakia lesions as 20-40% of cases are precancerous or cancerous at the time of biopsy and another 8-15% become cancerous over time. The exact cause of oral leukoplakia is not known. Factors that may increase the risk of developing oral leukoplakia include smoking, alcohol use, vitamin deficiencies, malocclusion, and a weakened immune system.Treatment depends on the biopsy results and the size, appearance, and location of the oral leukoplakia. Removal or ablation of the lesion by surgery, laser, or cryotherapy (use of low temperature) may be recommended. Last updated: 6/12/2015

MalaCards based summary : Oral Leukoplakia, also known as leukoplakia, oral, is related to leukoplakia and oral submucous fibrosis. An important gene associated with Oral Leukoplakia is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Celecoxib and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and liver, and related phenotype is no phenotypic analysis.

Related Diseases for Oral Leukoplakia

Diseases related to Oral Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 leukoplakia 30.7 GSTM1 GSTT1 MKI67 PCNA
2 oral submucous fibrosis 30.2 GSTM1 GSTT1
3 papilloma 30.0 CDKN2A PCNA TP53
4 squamous cell carcinoma 29.8 CDKN2A ERBB2 MKI67 TP53 XRCC1
5 oral cancer 29.0 CDKN2A GSTM1 GSTT1 PCNA TP53
6 esophageal cancer 28.4 CDKN2A ERBB2 GSTM1 GSTT1 TP53
7 basal cell carcinoma 27.8 CDKN2A GSTM1 GSTT1 MKI67 TP53 XRCC1
8 proliferative verrucous leukoplakia 11.8
9 oral hairy leukoplakia 11.6
10 dyskeratosis congenita 11.5
11 revesz syndrome 11.1
12 oral mucosa leukoplakia 11.1
13 dyskeratosis congenita, autosomal recessive 6 11.0
14 dyskeratosis congenita, autosomal dominant 6 11.0
15 dyskeratosis congenita, autosomal recessive 5 11.0
16 oral squamous cell carcinoma 10.5
17 brain ependymoma 10.4 MKI67 TP53
18 brain stem astrocytic neoplasm 10.3 CDKN2A TP53
19 lichen planus 10.3
20 squamous cell carcinoma of the oropharynx 10.3 CDKN2A TP53
21 adenosarcoma 10.3 MKI67 TP53
22 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
23 bartholin's gland benign neoplasm 10.3 CDKN2A TP53
24 soft tissue sarcoma 10.3 MKI67 TP53
25 bladder carcinoma in situ 10.3 CDKN2A TP53
26 anal squamous cell carcinoma 10.3 CDKN2A TP53
27 thyroid lymphoma 10.3 CDKN2A TP53
28 vulva squamous cell carcinoma 10.3 CDKN2A TP53
29 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
30 bone squamous cell carcinoma 10.3 CDKN2A TP53
31 megaesophagus 10.3 CDKN2A TP53
32 scrotal carcinoma 10.3 CDKN2A TP53
33 testicular torsion 10.3 PCNA TP53
34 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
35 embryonal sarcoma 10.3 MKI67 TP53
36 mature teratoma 10.3 PCNA TP53
37 anogenital venereal wart 10.3 CDKN2A TP53
38 balanitis xerotica obliterans 10.3 CDKN2A TP53
39 cervix uteri carcinoma in situ 10.3 CDKN2A TP53
40 fibrillary astrocytoma 10.3 PCNA TP53
41 small cell neuroendocrine carcinoma 10.3 CDKN2A TP53
42 meningeal melanomatosis 10.3 CDKN2A TP53
43 dedifferentiated liposarcoma 10.3 CDKN2A TP53
44 gastric lymphoma 10.3 PCNA TP53
45 bladder squamous cell carcinoma 10.3 CDKN2A TP53
46 oropharynx cancer 10.3 CDKN2A TP53
47 fibrosis of extraocular muscles, congenital, 1 10.3
48 endocervical adenocarcinoma 10.3 CDKN2A TP53
49 small cell sarcoma 10.3 CDKN2A TP53
50 cervix small cell carcinoma 10.3 CDKN2A TP53

Graphical network of the top 20 diseases related to Oral Leukoplakia:



Diseases related to Oral Leukoplakia

Symptoms & Phenotypes for Oral Leukoplakia

MGI Mouse Phenotypes related to Oral Leukoplakia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 PCNA TINF2 TP53 CDKN2A MKI67

Drugs & Therapeutics for Oral Leukoplakia

Drugs for Oral Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
2
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
3
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
4
Aminolevulinic acid Approved Phase 1, Phase 2 106-60-5 137
5
Trioxsalen Approved Phase 2 3902-71-4 5585
6
Metformin Approved Phase 2 657-24-9 4091 14219
7
Fenretinide Investigational Phase 2 65646-68-6
8
Maleic acid Experimental Phase 2 110-16-7 444266
9 Analgesics Phase 2,Phase 1
10 Cyclooxygenase 2 Inhibitors Phase 2
11 Cyclooxygenase Inhibitors Phase 2,Phase 1
12 Analgesics, Non-Narcotic Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 2,Phase 1
14 Anti-Inflammatory Agents Phase 2,Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
16 Antirheumatic Agents Phase 2,Phase 1
17 Ether Phase 2
18 Retinamide Phase 2
19 Hematoporphyrin Derivative Phase 2
20 Hematoporphyrins Phase 2
21 Dermatologic Agents Phase 1, Phase 2
22 Dihematoporphyrin Ether Phase 2
23 Hypoglycemic Agents Phase 2
24 Pharmaceutical Solutions Phase 1, Phase 2
25 Photosensitizing Agents Phase 1, Phase 2
26 Tea Nutraceutical Phase 2
27
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
28 Fibrinolytic Agents Phase 1
29 Platelet Aggregation Inhibitors Phase 1
30 Antipyretics Phase 1
31
Heparin Approved, Investigational 9005-49-6 46507594 772
32
Sulindac Approved, Investigational 38194-50-2 1548887 5352
33 calcium heparin
34 Coagulants
35 Tolonium Chloride
36 Hemostatics

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia Completed NCT00155337 Phase 4
2 Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia Unknown status NCT00052611 Phase 2 celecoxib
3 Rosiglitazone Maleate in Treating Patients With Oral Leukoplakia Completed NCT00369174 Phase 2 rosiglitazone maleate
4 Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia Completed NCT00099021 Phase 2 pioglitazone hydrochloride
5 Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia Completed NCT00330382 Phase 2 Bowman-Birk inhibitor concentrate
6 Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia Completed NCT00101335 Phase 2 celecoxib
7 Fenretinide in Treating Patients With Leukoplakia of the Mouth Completed NCT00004161 Phase 2 fenretinide;Placebo
8 Treatment of Oral Premalignant Lesions With 5-ALA PDT Completed NCT00571974 Phase 1, Phase 2 5-Aminolevulinic Acid (Levulan KerastickTM)
9 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract Completed NCT00453336 Phase 2 Porfimer Sodium
10 Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion Active, not recruiting NCT02581137 Phase 2 Metformin Hydrochloride
11 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
12 Pioglitazone for Oral Premalignant Lesions Terminated NCT00951379 Phase 2 Pioglitazone hydrochloride
13 Aspirin Mouthwash in Treating Patients With Oral Leukoplakia Completed NCT01238185 Phase 1 acetylsalicylic acid
14 Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia Terminated NCT00571558 Phase 1 aminolevulinic acid hydrochloride;photodynamic therapy
15 Least Invasive Nonlinear Light Microscopy Unknown status NCT00767442
16 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544
17 Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia Completed NCT03233165
18 Biomarkers for Oral Cancer Completed NCT00341497
19 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
20 Clinical Research Core Dental Screening Protocol Completed NCT00090818
21 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia Completed NCT00835341
22 A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery Recruiting NCT01355926
23 A Randomized Study of Sulindac in Oral Premalignant Lesions Active, not recruiting NCT00299195 sulindac;Placebo

Search NIH Clinical Center for Oral Leukoplakia

Genetic Tests for Oral Leukoplakia

Genetic tests related to Oral Leukoplakia:

# Genetic test Affiliating Genes
1 Oral Leukoplakia 28

Anatomical Context for Oral Leukoplakia

MalaCards organs/tissues related to Oral Leukoplakia:

38
Tongue, Testes, Liver, T Cells, Breast, Colon

Publications for Oral Leukoplakia

Articles related to Oral Leukoplakia:

(show top 50) (show all 535)
# Title Authors Year
1
Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment. ( 29443777 )
2018
2
Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study. ( 29428194 )
2018
3
A clinical diagnosis of oral leukoplakia; A guide for dentists. ( 29274164 )
2018
4
Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. ( 29436667 )
2018
5
T cells are involved in the induction of macrophage phenotypes in oral leukoplakia and squamous cell carcinoma-a preliminary report. ( 29108105 )
2018
6
Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3 in Oral Leukoplakia and Oral Squamous Cell Carcinoma with Deleterious Habits using Polymerase Chain Reaction. ( 28904918 )
2017
7
Interventions for treating oral leukoplakia to prevent oral cancer. ( 28537153 )
2017
8
Oral leukoplakia and oral cavity squamous cell carcinoma. ( 28916027 )
2017
9
Evaluation of Different Laser-Supported Surgical Protocols for the Treatment of Oral Leukoplakia: A Long-Term Follow-Up. ( 28426376 )
2017
10
Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners. ( 29097794 )
2017
11
PTEN allelic loss is an important mechanism in the late stage of development of oral leukoplakia into oral squamous cell carcinoma. ( 28858374 )
2017
12
Quantitative prediction of oral cancer risk in patients with oral leukoplakia. ( 28545021 )
2017
13
Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis. ( 29207828 )
2017
14
Ultrastructural Changes during the Life Cycle of<i>Mycoplasma salivarium</i>in Oral Biopsies from Patients with Oral Leukoplakia. ( 28983467 )
2017
15
Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study. ( 28809365 )
2017
16
Limited evidence for interventions to treat oral leukoplakia. ( 29075031 )
2017
17
Association between oral leukoplakia and risk of upper gastrointestinal cancer death: A follow-up study of the Linxian General Population Trial. ( 28929584 )
2017
18
Plasma HPV DNA is detectable in oral leukoplakia patients. ( 28554767 )
2017
19
In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia. ( 28580171 )
2017
20
New definition proposed for oral leukoplakia. ( 28928786 )
2017
21
The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for<i>Fusobacterium, Leptotrichia, Campylobacter</i>, and<i>Rothia</i>Species. ( 29250055 )
2017
22
Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma. ( 29189260 )
2017
23
Malignant transformation of oral leukoplakia in a patient with dyskeratosis congenita. ( 28923296 )
2017
24
Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers. ( 28797449 )
2017
25
Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. ( 28939076 )
2017
26
Cytological study of DNA content and nuclear morphometric analysis for aid in the diagnosis of high-grade dysplasia within oral leukoplakia. ( 28732697 )
2017
27
Factors affecting Clinical Outcomes after Treatment of Oral Leukoplakia with CO2 and Diode Laser. ( 28874640 )
2017
28
Expression of Human Papillomavirus DNA and p53 Polymorphisms through Polymerase Chain Reaction in Normal Mucosa and Oral Leukoplakia Individuals with Deleterious Oral Habits. ( 28584747 )
2017
29
Serum metabolomics in oral leukoplakia and oral squamous cell carcinoma. ( 28862226 )
2017
30
Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts. ( 29068672 )
2017
31
A comparative evaluation: Oral leukoplakia surgical management using diode laser, CO2 laser, and cryosurgery. ( 28638555 )
2017
32
Evaluation of Total and Lipid Bound Sialic Acid in Serum in Oral Leukoplakia. ( 28511503 )
2017
33
Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia. ( 28256094 )
2017
34
Candida infection in oral leukoplakia: an unperceived public health problem. ( 27538681 )
2016
35
Prevalence of Carcinomatous Foci in Oral Leukoplakia: A Clinicopathologic Study of 546 Indian Samples. ( 27656569 )
2016
36
Changes in the salivary microbiota of oral leukoplakia and oral cancer. ( 27026576 )
2016
37
Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression. ( 27356725 )
2016
38
Interventions for treating oral leukoplakia to prevent oral cancer. ( 27471845 )
2016
39
Oral leukoplakia - To treat or not to treat. ( 26785709 )
2016
40
Computer aided morphometric analysis of oral leukoplakia and oral squamous cell carcinoma. ( 26983454 )
2016
41
A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia. ( 27994417 )
2016
42
p53 and ki67 as biomarkers in determining response to chemoprevention for oral leukoplakia. ( 27605086 )
2016
43
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma. ( 27225603 )
2016
44
Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index. ( 27595730 )
2016
45
GSTM1 null polymorphism prevalence in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study. ( 27723629 )
2016
46
A proteomic approach to compare saliva from individuals with and without oral leukoplakia. ( 27478070 )
2016
47
Semi-quantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia. ( 28036153 )
2016
48
Association between smoking, glycemia, blood lipoproteins, and risk of oral leukoplakia. ( 27219072 )
2016
49
Associations Among Glutathione S-Transferase T1, M1, and P1 Polymorphisms and the Risk of Oral Leukoplakia. ( 27152506 )
2016
50
Role of human papilloma virus in oral leukoplakia. ( 27146781 )
2016

Variations for Oral Leukoplakia

Expression for Oral Leukoplakia

Search GEO for disease gene expression data for Oral Leukoplakia.

Pathways for Oral Leukoplakia

Pathways related to Oral Leukoplakia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 CDKN2A ERBB2 PCNA TP53
2 12.38 CDKN2A ERBB2 GSTM1 GSTT1 TP53
3
Show member pathways
12.22 CDKN2A ERBB2 GSTM1 GSTT1 TP53
4 12.17 CDKN2A PCNA TP53
5 12.11 CDKN2A PCNA TP53
6
Show member pathways
11.84 CDKN2A ERBB2 TP53
7 11.82 CDKN2A MKI67 PCNA TP53 XRCC1
8 11.78 GSTM1 GSTT1 TP53
9 11.73 CDKN2A PCNA TP53
10 11.64 CDKN2A ERBB2 TP53
11 11.57 CDKN2A PCNA TP53
12 11.36 CDKN2A ERBB2 TP53
13 11.24 PCNA TP53
14 11.07 PCNA TP53
15 11.06 CDKN2A TP53
16 11.01 PCNA TP53
17 11 GSTM1 GSTT1
18 10.9 GSTM1 GSTT1
19 10.88 CDKN2A ERBB2 GSTM1 GSTT1 TP53
20 10.85 CDKN2A TP53
21
Show member pathways
10.84 CDKN2A TP53

GO Terms for Oral Leukoplakia

Cellular components related to Oral Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 9.16 PCNA TP53
2 nuclear chromosome, telomeric region GO:0000784 9.13 PCNA TINF2 XRCC1
3 nuclear body GO:0016604 8.92 MKI67 PCNA TINF2 TP53

Biological processes related to Oral Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.46 ERBB2 MKI67 PCNA TP53
2 base-excision repair GO:0006284 9.4 TP53 XRCC1
3 nucleotide-excision repair, DNA gap filling GO:0006297 9.37 PCNA XRCC1
4 glutathione derivative biosynthetic process GO:1901687 9.32 GSTM1 GSTT1
5 replicative senescence GO:0090399 9.26 CDKN2A TP53
6 negative regulation of immature T cell proliferation in thymus GO:0033088 8.96 CDKN2A ERBB2
7 negative regulation of protein ADP-ribosylation GO:0010836 8.62 TINF2 XRCC1

Molecular functions related to Oral Leukoplakia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.37 CDKN2A TP53
2 protein C-terminus binding GO:0008022 9.33 ERBB2 MKI67 TP53
3 glutathione transferase activity GO:0004364 9.32 GSTM1 GSTT1
4 histone acetyltransferase binding GO:0035035 9.26 PCNA TP53
5 enzyme binding GO:0019899 9.26 GSTM1 PCNA TP53 XRCC1
6 damaged DNA binding GO:0003684 8.8 PCNA TP53 XRCC1

Sources for Oral Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....