MCID: ORL013
MIFTS: 45

Oral Lichen Planus malady

Oral category

Summaries for Oral Lichen Planus

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Oral lichen planus is a inflammatory condition that affects the inside of the mouth.  signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. severe lichen planus slightly increases the risk for oral cancer. oral lichen planus may occur alone or in combination with other skin forms of lichen planus. last updated: 7/20/2011

MalaCards: Oral Lichen Planus, also known as oral lichenoid lesions, is related to lichen planus and squamous cell carcinoma. An important gene associated with Oral Lichen Planus is CD207 (CD207 molecule, langerin), and among its related pathways are MicroRNAs in cancer and Cytoskeleton remodeling Keratin filaments. The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and smooth muscle, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Oral Lichen Planus

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral


Aliases & Descriptions:

oral lichen planus 43
oral lichenoid lesions 43
lichen planus, oral 61
lichen planus oral 45


Related Diseases for Oral Lichen Planus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1lichen planus32.4KRT10, KRT16, KRT1, KRT13
2squamous cell carcinoma31.3KRT15, KRT16, KRT1, KRT13, KRT10, CEACAM1
3leukoplakia31.2KRT1, KRT13
4alopecia30.3KRT15
5oral erosive lichen11.0
6oral squamous cell carcinoma10.9
7hepatitis c10.8
8oral leukoplakia10.8
9hepatitis a10.7
10hepatitis e10.7
11oral cancer10.7
12hepatitis c virus10.7
13atrophic lichen planus10.6
14burning mouth syndrome10.5
15pemphigus10.5
16stomatitis10.5
17pemphigus vulgaris10.5
18aphthous stomatitis10.4
19verrucous carcinoma10.4
20anal squamous cell carcinoma10.4
21thymoma10.4
22erythroplakia10.4
23pemphigus foliaceus10.4
24bullous lichen planus10.4
25squamous cell papilloma10.2
26bullous pemphigoid10.2
27systemic lupus erythematosus10.2
28good syndrome10.2
29hepatitis d10.2
30oral candidiasis10.2
31vitiligo10.2
32scurvy10.2
33alopecia areata10.2
34thyroiditis10.2
35viral hepatitis10.2
36cheilitis glandularis10.2
37lichen planus pigmentosus10.2
38lichen sclerosus10.2
39paraneoplastic syndromes10.2
40h. pylori infection10.2
41lichen planus pemphigoides10.2
42mucous membrane pemphigoid10.2
43pemphigus erythematosus10.2
44vulvovaginal gingival syndrome10.2
45oral submucous fibrosis10.2
46psoriasis10.0KRT13, KRT16, KRT1, KRT10, KRT15, CCL5
47melanoma10.0CD27, CD274, CD1A, CEACAM1, CD83, CD68
48hepatocellular carcinoma10.0KRT1, KRT13, CEACAM1, CCL5, CCR1
49asthma10.0CD1A, CCL5, CCR1
50cholesteatoma10.0KRT13, KRT16, KRT10

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to oral lichen planus

Clinical Features for Oral Lichen Planus

Drugs & Therapeutics for Oral Lichen Planus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Lichen Planus

Drug clinical trials:

Search ClinicalTrials for Oral Lichen Planus

Search NIH Clinical Center for Oral Lichen Planus

Search CenterWatch for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Oral Lichen Planus:

33
Whole blood, Lymph node, Smooth muscle, Liver, Thyroid, Skin, Monocytes, T cells, B cells, Endothelial, Tongue

Animal Models for Oral Lichen Planus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Oral Lichen Planus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.6CCR1, CD68, CD274, CD207, CD27, CD83
2MP:000538710.3CEACAM1, CCL5, CCR1, CD68, CD274, CD207

Publications for Oral Lichen Planus

Sources:
51PubMed
See all sources

Articles related to Oral Lichen Planus:

(show top 50)    (show all 643)
idTitleAuthorsYear
1
The malignant transformation of oral lichen planus and oral lichenoid lesions: A systematic review. (24379329)
2014
2
Analysis of the expression of heat-shock protein 27 in patients with oral lichen planus. (22747996)
2013
3
In vitro culture system for keratinocytes obtained from oral lichen planus lesions. (23949019)
2013
4
Erratum to: Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (24173539)
2013
5
Nitric oxide synthase isoenzyme expression in human oral lichen planus. (24382189)
2013
6
Identifying factors associated with diagnostic concordance/discordance in oral lichen planus. (23773425)
2013
7
TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk. (24028589)
2013
8
Oral lichen planus in thai patients has a low prevalence of human papillomavirus. (23762572)
2013
9
A tongue mass in a patient with oral lichen planus. (22673221)
2012
10
Oral lichen planus: REU scoring system correlates with pain. (22727095)
2012
11
Oral lichen planus. (22470165)
2012
12
TLR4 and TLR9 are induced in oral lichen planus. (22672741)
2012
13
Expression of matrix metalloproteinase 9 in patients with oral lichen planus. (22696931)
2012
14
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
15
Oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. (21330164)
2011
16
Squamous cell carcinoma development in previously diagnosed oral lichen planus: de novo or transformation? (21868266)
2011
17
Association between hepatitis C virus and oral lichen planus: HCV and oral Lichen Planus. (22087133)
2011
18
Oral lichen planus. (21093625)
2011
19
Perforin and granzyme B expression in oral and cutaneous lichen planus - a comparative study. (22050094)
2011
20
Oral lichen planus - Review on etiopathogenesis. (22442603)
2011
21
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. (20456611)
2010
22
The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders. (19767711)
2010
23
Caspase cascade pathways in apoptosis of oral lichen planus. (20875757)
2010
24
Expression of caspase-8, receptor interacting protein and nuclear factor-kappaBp65 in oral lichen planus]. (20368033)
2010
25
Oral alitretinoin in lichen planus: two case reports. (20814633)
2010
26
Oral Lichen Planus: a retrospective study of 420 Iranian patients. (19300365)
2009
27
Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis. (19893941)
2009
28
Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus: a clinicopathologic study in atrophic-erosive and reticular form. (19453840)
2009
29
Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma. (19751907)
2009
30
Expression of novel p53 isoforms in oral lichen planus. (17418619)
2008
31
A case of cheilitis glandularis superimposed on oral lichen planus: successful palliative treatment with topical tacrolimus and pimecrolimus. (17659026)
2007
32
Expressions of NF--kappaBp65, TRAF2, cyclinD1 and their association with cell apoptosis in oral lichen planus]. (18024283)
2007
33
The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. (17112770)
2007
34
Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus. (16762012)
2006
35
Image cytometric evaluation of nuclear texture features and DNA content of the reticular form of oral lichen planus. (17067008)
2006
36
Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation. (16914114)
2006
37
Histochemical analysis of pathological alterations in oral lichen planus and oral lichenoid lesions. (17220615)
2006
38
Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus. (16850138)
2006
39
The effectiveness of 1% pimecrolimus cream in the treatment of oral erosive lichen planus. (15857105)
2005
40
Oral erosive lichen planus associated with thymoma. (11903672)
2001
41
Folate and vitamin B12 levels in patients with oral lichen planus, stomatitis or glossitis. (11944731)
2001
42
Recent advances on the pathogenesis of oral lichen planus (OLP). The adhesion molecules. (10431536)
1999
43
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis. (10226943)
1999
44
Reduction of epithelial dendritic cells in keratotic lesion of oral lichen planus. (9951149)
1998
45
Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas. (9115910)
1997
46
Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. (7552878)
1995
47
Squamous cell carcinoma in oral lichen ruber planus. A clinico-pathological and immunohistochemical study of 11 cases]. (7700225)
1994
48
Increased submucosal factor XIIIa-positive dendrocytes in oral lichen planus. (7517451)
1994
49
Induction and upregulation of adhesion receptors in oral and dermal lichen planus. (1981078)
1990
50
Evaluation of Langerhans cells and T cell subsets in oral lichen planus, in comparison with oral leukoplakia. (3267121)
1988

Genetic Variations for Oral Lichen Planus

Expression for genes affiliated with Oral Lichen Planus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for genes affiliated with Oral Lichen Planus

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Oral Lichen Planus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6MIR203, MIR27B, MIR137, MIR146A, MIR21
210.5KRT16, KRT1, KRT13
310.5MIR203, MIR27B, MIR21

Compounds for genes affiliated with Oral Lichen Planus

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Oral Lichen Planus according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2411.9CEACAM1, CCL5, CCR1, KRT16, KRT1, KRT13
2paraffin4510.8CD68, CD83, KRT16, KRT1, KRT13, KRT10
3proline4510.8KRT10, KRT13, KRT1, KRT16, CCL5
4calcipotriol45 60 29 1113.8KRT15, KRT10, KRT16
5isotretinoin45 1111.8KRT16, KRT1, KRT10
6calcitriol45 60 11 2413.7CCL5, CD83, KRT16, KRT10
7dithranol4510.7KRT10, KRT16
8calcium45 50 11 2413.6CCL5, CCR1, CD207, CD27, KRT1, KRT13
9tazarotene45 1111.6KRT10, KRT1
10serine4510.6CCL5, CCR1, KRT16, KRT1
11tyrosine4510.6CEACAM1, KRT15, KRT10, KRT1, FCAR, CCR1
12dexamethasone45 50 29 1113.4CCR1, CCL5
13mdms4510.2CCL5, CCR1

GO Terms for genes affiliated with Oral Lichen Planus

Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6CEACAM1, FCAR, CD83, CD27, CD1A, CCR1
2external side of plasma membraneGO:00989710.5CD83, CD27, CD274, CCR1
3keratin filamentGO:04509510.4KRT10, KRT13, KRT1
4intermediate filamentGO:00588210.2KRT16, KRT10, KRT15

Biological processes related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00854410.6KRT15, KRT13, KRT16
2positive regulation of monocyte chemotaxisGO:09002610.5CCR1, CCL5
3chemokine-mediated signaling pathwayGO:07009810.5CCR1, CCL5
4dendritic cell chemotaxisGO:00240710.4CCL5, CCR1
5immune responseGO:00695510.2FCAR, CD274, CD1A, CCR1

Products for genes affiliated with Oral Lichen Planus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Lichen Planus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet