MCID: ORL013
MIFTS: 41

Oral Lichen Planus malady

Rare diseases, Oral diseases categories

Summaries for Oral Lichen Planus

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Sources:
44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Oral lichen planus is a inflammatory condition that affects the inside of the mouth.  signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. severe lichen planus slightly increases the risk for oral cancer. oral lichen planus may occur alone or in combination with other skin forms of lichen planus. last updated: 7/20/2011

MalaCards: Oral Lichen Planus, also known as oral lichenoid lesions, is related to lichen planus and leukoplakia. An important gene associated with Oral Lichen Planus is CD207 (CD207 molecule, langerin), and among its related pathways are Cytoskeletal Signaling and Staphylococcus aureus infection. The compounds alefacept and dithranol have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and t cells.

Aliases & Classifications for Oral Lichen Planus

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Sources:
44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Aliases & Descriptions:

oral lichen planus 44
oral lichenoid lesions 44
lichen planus, oral 63
lichen planus oral 46


Related Diseases for Oral Lichen Planus

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to oral lichen planus

Symptoms for Oral Lichen Planus

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Drugs & Therapeutics for Oral Lichen Planus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Oral Lichen Planus

Drug clinical trials:

Search ClinicalTrials for Oral Lichen Planus

Search NIH Clinical Center for Oral Lichen Planus

Search CenterWatch for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

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Anatomical Context for Oral Lichen Planus

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Sources:
34MalaCards
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MalaCards organs/tissues related to Oral Lichen Planus:

34
Tongue, Skin, T cells, Thyroid, Endothelial, Testes, Lymph node, Smooth muscle, Monocytes

Animal Models for Oral Lichen Planus or affiliated genes

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Publications for Oral Lichen Planus

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Sources:
53PubMed
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Articles related to Oral Lichen Planus:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. (23537868)
2013
2
CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study. (23489895)
2013
3
Oral lichen planus in Arab countries : a review. (24245546)
2013
4
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. (23892499)
2013
5
Analysis of the expression of heat-shock protein 27 in patients with oral lichen planus. (22747996)
2013
6
The influence of psychological state on oral lichen planus. (24053073)
2013
7
The malignant potential of oral lichen planus--confusion galore. (23312540)
2013
8
Interaction between oral lichen planus and chronic periodontitis with Th17-associated cytokines in serum. (23338155)
2013
9
Reduced immune responses to purified protein derivative and Candida albicans in oral lichen planus. (23607487)
2013
10
Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. (21943223)
2012
11
Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease. (22017396)
2012
12
Salivary and serum interleukin-18 in patients with oral lichen planus: a study in an ethnic Chinese population. (21484426)
2012
13
A tongue mass in a patient with oral lichen planus. (22673221)
2012
14
Treatment of symptomatic oral lichen planus (OLP) with 0.1% tacrolimus powder in Oraguard-B - A pilot prospective study. (23960543)
2012
15
A retrospective study of oral lichen planus in paediatric population. (23248468)
2012
16
The dynamics of oral lichen planus: a retrospective clinicopathological study. (22160614)
2012
17
The roles of matrix metalloproteinases-2, -7, -10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus. (22554030)
2012
18
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
19
Histopathological aspects and local implications of oxidative stress in patients with oral lichen planus. (22203938)
2011
20
Immunohistochemical expression of p16(INK4A) protein in oral lichen planus. (21612953)
2011
21
Oral lichen planus and the p53 family: what do we know? (21138483)
2011
22
The quality of patient-orientated Internet information on oral lichen planus: a pilot study. (20586847)
2010
23
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. (20456611)
2010
24
Clinical features of oral lichen planus. A retrospective study of 65 cases. (20383118)
2010
25
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. (20975919)
2009
26
Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. (18627473)
2009
27
Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. (19884710)
2009
28
Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase. (19614863)
2009
29
Is ethanol consumption beneficial for oral lichen planus? (19232837)
2009
30
Oral Lichen Planus: a retrospective study of 420 Iranian patients. (19300365)
2009
31
Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus]. (18683732)
2008
32
A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus. (18230389)
2008
33
hTR RNA component as a marker of cellular proliferation in oral lichen planus. (18712976)
2008
34
Survival signalling in keratinocytes of erythematous oral lichen planus. (17391299)
2007
35
A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus. (17238974)
2007
36
Clinical and immunopathologic findings in oral lichen planus pemphigoides. (17531940)
2007
37
A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. (17604143)
2007
38
Oral lichen planus: clinical and histological evaluation in an open trial using a low molecular weight heparinoid (sulodexide). (16911394)
2006
39
DNA cytometry of oral leukoplakia and oral lichen planus. (16505806)
2006
40
DNA cytometry of oral leukoplakia and oral lichen planus. (15800471)
2005
41
A systematic review of placebo-controlled randomized clinical trials of treatments used in oral lichen planus. (16086745)
2005
42
Functions of the cytokines in relation oral lichen planus-hepatitis C. (15800466)
2005
43
Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings. (12558634)
2003
44
Recent advances on the pathogenesis of oral lichen planus (OLP). The adhesion molecules. (10431536)
1999
45
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
46
Apoptosis-associated markers in oral lichen planus. (9176791)
1997
47
Altered interface adhesion molecules in oral lichen planus. (9081757)
1996
48
Cytokine production by keratinocytes and mononuclear infiltrates in oral lichen planus. (7965886)
1994
49
Evaluation of Langerhans cells and T cell subsets in oral lichen planus, in comparison with oral leukoplakia. (3267121)
1988
50
Oral lichen planus, leukoplakia and erythroplakia: some observations on diagnosis and clinical management. (6934472)
1980

Variations for Oral Lichen Planus

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Expression for genes affiliated with Oral Lichen Planus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for genes affiliated with Oral Lichen Planus

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Sources:
51PathCards, 5Cell Signaling Technology, 31KEGG, 61Thomson Reuters
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Pathways related to Oral Lichen Planus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3KRT13, KRT4, KRT10
29.0KRT10, FCAR, FCGR3B
38.8KRT13, KRT16, KRT4

Compounds for genes affiliated with Oral Lichen Planus

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Oral Lichen Planus according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1alefacept46 1210.7CD58, FCGR3B
2dithranol469.6KRT16, KRT10
3calcipotriol46 62 30 1212.5KRT16, KRT10
4isotretinoin46 1210.4KRT16, KRT10
5retinoid468.9KRT10, KRT4, KRT16
6mannose468.9CD207, FCAR, FCGR3B, DEFB4A
7paraffin468.7DEFB4A, KRT10, KRT16, KRT13
8lipid468.7CD58, CD1A, FCGR3B, DEFB4A
9proline468.7KRT13, KRT16, KRT10
10calcium46 52 25 1211.2DEFB4A, FCGR3B, KRT10, KRT13, CD27, CD207
11retinoic acid46 258.9DEFB4A, KRT10, KRT4, KRT16, KRT13, CD58
12serine467.7FCGR3B, FCAR, KRT10, KRT16, CD27

GO Terms for genes affiliated with Oral Lichen Planus

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Sources:
17Gene Ontology
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Cellular components related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.2KRT10, KRT4, KRT13
2integral component of plasma membraneGO:0058878.9CD1A, CD58, FCAR, CD27
3intermediate filamentGO:0058828.5KRT16, KRT10, KRT4

Biological processes related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069558.6CD1A, FCAR, FCGR3B, DEFB4A

Products for genes affiliated with Oral Lichen Planus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Lichen Planus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet