MCID: ORL013
MIFTS: 47

Oral Lichen Planus malady

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Oral Lichen Planus

Aliases & Descriptions for Oral Lichen Planus:

Name: Oral Lichen Planus 50
Oral Lichenoid Lesions 50
Lichen Planus, Oral 69
Lichen Planus Oral 52

Classifications:



Summaries for Oral Lichen Planus

NIH Rare Diseases : 50 oral lichen planus is a inflammatory condition that affects the inside of the mouth.  signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. severe lichen planus slightly increases the risk for oral cancer. oral lichen planus may occur alone or in combination with other skin forms of lichen planus. last updated: 7/20/2011

MalaCards based summary : Oral Lichen Planus, also known as oral lichenoid lesions, is related to lichen planus and hepatitis, and has symptoms including oral manifestations An important gene associated with Oral Lichen Planus is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Tacrolimus and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and t cells, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and cardiovascular system

Related Diseases for Oral Lichen Planus

Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 lichen planus 11.2
2 hepatitis 10.5
3 hepatitis c 10.5
4 squamous cell carcinoma 10.5
5 leukoplakia 10.4
6 hepatitis c virus 10.4
7 oral squamous cell carcinoma 10.4
8 gingivitis 10.3
9 tonsil cancer 10.3 CASP3 ICAM1
10 periodontitis 10.2
11 oral leukoplakia 10.2
12 erb-duchenne and dejerine-klumpke palsies 10.2 CCL5 ICAM1 VCAM1
13 dentinogenesis imperfecta 10.2 CCL5 ICAM1 VCAM1
14 porokeratosis of mibelli 10.2 ICAM1 IL1A VCAM1
15 pigmentation disease 10.2 CCL5 ICAM1 VCAM1
16 hypopyon ulcer 10.2 ICAM1 VCAM1
17 mucositis 10.2
18 immunoglobulin g deficiency 10.2 CASP3 CCL5 IL1A
19 brown's tendon sheath syndrome 10.2 ICAM1 IL1A VCAM1
20 macrodactyly of the foot 10.2 ICAM1 VCAM1
21 perrault syndrome 10.2 ICAM1 MMP1 VCAM1
22 xerophthalmia 10.2 ICAM1 MMP1 VCAM1
23 latent syphilis 10.1 CCL5 CXCR3 ICAM1
24 thyroiditis 10.1
25 oral cancer 10.1
26 stomatitis 10.1
27 malignant peritoneal solitary fibrous tumor 10.1 CCL5 ICAM1 VCAM1
28 visceral steatosis 10.1 CCL5 CXCR3 ICAM1
29 spastic hemiplegia 10.1 ICAM1 IL1A MMP1
30 synovium cancer 10.1 ICAM1 MMP1 VCAM1
31 ependymoblastoma 10.1 CCR5 ICAM1 VCAM1
32 smooth muscle tumor 10.1 CCL5 CXCR3 IL1A
33 eating seizures 10.1 CCL5 CCR5
34 bare lymphocyte syndrome, type i 10.1 CCL5 ICAM1 IL1A VCAM1
35 ovarian clear cell malignant adenofibroma 10.1 CD58 ICAM1 VCAM1
36 mast-cell leukemia 10.1 CCL5 CXCR3 ICAM1
37 benign eccrine breast spiradenoma 10.1 CASP3 CXCR3 ICAM1
38 benign secondary hypertension 10.1 CCR5 ICAM1 VCAM1
39 burns 10.1
40 pemphigus 10.1
41 burning mouth syndrome 10.1
42 parasitic protozoa infectious disease 10.1 CXCR3 ICAM1 IL1A
43 deafness, autosomal recessive 67 10.1 CCL5 CXCR3 ICAM1
44 lymphedema 10.1 ICAM1 IL1A TP63 VCAM1
45 senile atrophy of choroid 10.1 CASP3 MMP1
46 hidradenitis suppurativa 10.1 CCL5 HSPD1
47 esophageal candidiasis 10.1 CXCR3 ICAM1 IL1A
48 plantar fasciitis 10.1 CCL5 CCR5 VCAM1
49 papilloma 10.1
50 osteodysplasty precocious of danks mayne and kozlowski 10.0 CCL5 CCR5 CXCR3

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to Oral Lichen Planus

Symptoms & Phenotypes for Oral Lichen Planus

UMLS symptoms related to Oral Lichen Planus:


oral manifestations

GenomeRNAi Phenotypes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 8.8 CD58 HSPD1 IL1A

MGI Mouse Phenotypes related to Oral Lichen Planus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CASP3 CCR5 CXCR3 ICAM1 IL1A TIMP2
2 hematopoietic system MP:0005397 9.97 IL1A TIMP2 VCAM1 BAX CASP3 CCL5
3 homeostasis/metabolism MP:0005376 9.96 BAX CASP3 CCR5 CXCR3 ICAM1 IL1A
4 immune system MP:0005387 9.9 BAX CASP3 CCL5 CCR5 CXCR3 ICAM1
5 muscle MP:0005369 9.43 BAX CASP3 CCR5 HSPD1 ICAM1 TP63
6 neoplasm MP:0002006 9.17 BAX CCR5 CXCR3 ICAM1 IL1A MMP1

Drugs & Therapeutics for Oral Lichen Planus

Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
3
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
4
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
5
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
9 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
10
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
11 triamcinolone acetonide Phase 4,Phase 3,Phase 2
12 Analgesics Phase 4,Phase 3,Phase 2
13 glucocorticoids Phase 4,Phase 3,Phase 2
14 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
15 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
16 Dermatologic Agents Phase 4,Phase 3,Phase 2
17 Hormone Antagonists Phase 4,Phase 3,Phase 2
18 Triamcinolone diacetate Phase 4,Phase 3,Phase 2
19 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2
20 Hormones Phase 4,Phase 3,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
24 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Antiemetics Phase 4,Phase 3,Phase 2
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
28 Antirheumatic Agents Phase 4,Phase 3,Phase 2
29 Autonomic Agents Phase 4,Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
31 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
32 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
33
Lactitol Phase 4 585-86-4 3871
34 Prednisolone acetate Phase 4,Phase 2
35 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
36 Neuroprotective Agents Phase 4
37 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
38 Prednisolone hemisuccinate Phase 4,Phase 2
39 Prednisolone phosphate Phase 4,Phase 2
40 Antifungal Agents Phase 4,Phase 3
41 Radiation-Protective Agents Phase 4,Phase 2
42 Respiratory System Agents Phase 4,Phase 3,Phase 2
43 Methylprednisolone acetate Phase 4,Phase 2
44 Methylprednisolone Hemisuccinate Phase 4,Phase 2
45 Betamethasone benzoate Phase 4,Phase 3,Phase 2
46 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2
47 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2
48 Carotenoids Phase 4,Phase 2
49
Chitosan Nutraceutical Phase 4 9012-76-4 71853
50
Lycopene Nutraceutical Phase 4,Phase 2 502-65-8 446925

Interventional clinical trials:

(show all 49)
id Name Status NCT ID Phase
1 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4
2 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4
4 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3
5 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3
6 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3
7 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
8 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3
9 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2
10 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2
11 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2
12 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2
13 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2
14 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2
15 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2
16 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2
17 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2
18 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2
19 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2
20 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2
21 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2
22 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2
23 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2
24 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2
25 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Recruiting NCT03011658 Phase 1, Phase 2
26 Dexamethasone Solution for the Treatment of Oral Lichen Planus Not yet recruiting NCT02850601 Phase 2
27 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2
28 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2
29 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2
30 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2
31 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
32 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1
33 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
34 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107
35 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607
36 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690
37 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
38 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed NCT03031899
39 Biomarkers for Oral Cancer Completed NCT00341497
40 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601
41 Clinical Research Core Dental Screening Protocol Completed NCT00090818
42 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
43 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Recruiting NCT02276573
44 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Recruiting NCT02532166
45 Tobacco Cessation Intervention Study for Oral Diseases Recruiting NCT02737176
46 Vaginal and Oral Microbiome Crosstalk Recruiting NCT02898818
47 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus Not yet recruiting NCT03052179
48 Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study Not yet recruiting NCT02332486
49 Tacrolimus Ointment in Oral Lichen Planus Terminated NCT01544842

Search NIH Clinical Center for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

Anatomical Context for Oral Lichen Planus

MalaCards organs/tissues related to Oral Lichen Planus:

39
Tongue, Skin, T Cells, Thyroid, Testes, Endothelial, Smooth Muscle

Publications for Oral Lichen Planus

Articles related to Oral Lichen Planus:

(show top 50) (show all 712)
id Title Authors Year
1
Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. ( 27917729 )
2017
2
Medical treatments for pregnant patients with oral lichen planus. ( 27826983 )
2017
3
Interventions for the management of Oral lichen planus: A review of the conventional and novel therapies. ( 28055124 )
2017
4
Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. ( 28076499 )
2017
5
Identification of AgNORs and cytopathological changes in oral lichen planus lesions. ( 27916273 )
2017
6
TRPA1 may contribute to the exacerbation of oral lichen planus through Koebner phenomenon. ( 28067971 )
2017
7
DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects. ( 27770642 )
2017
8
Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression. ( 27913255 )
2017
9
Phenotypically non-suppressive cells predominate among FoxP3-positive cells in oral lichen planus. ( 27084447 )
2016
10
Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. ( 27862315 )
2016
11
Image-based DNA ploidy analysis aids prediction of malignant transformation in oral lichen planus. ( 27084261 )
2016
12
Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus - an immunohistochemical study with supportive histochemical analysis. ( 27889928 )
2016
13
Oral candidiasis following steroid therapy for oral lichen planus. ( 26599999 )
2016
14
ALK1 expression in oral lichen planus: a possible relation to microvessel density. ( 26662187 )
2016
15
Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis. ( 27504405 )
2016
16
AAOM Clinical Practice Statement: Subject: Oral lichen planus and oral cancer. ( 27492565 )
2016
17
Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids. ( 27129091 )
2016
18
Lack of Relationship between Oral Lichen Planus and Hepatitis B and C Virus Infection: A Report from Southeast of Iran. ( 27530572 )
2016
19
Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3. ( 27458049 )
2016
20
Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. ( 27106476 )
2016
21
Cathepsin K expression is increased in oral lichen planus. ( 27152719 )
2016
22
The efficacy of Aloe Vera in management of oral lichen planus: a systematic review and meta-analysis. ( 28029732 )
2016
23
The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. ( 27008253 )
2016
24
Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study. ( 27857766 )
2016
25
Topical Tocopherol for treatment of reticular oral lichen planus: randomized, double-blind, crossover study. ( 27543905 )
2016
26
Clinical profile of 108 cases of oral lichen planus. ( 27021539 )
2016
27
The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. ( 27031060 )
2016
28
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
29
Association of genetic polymorphisms in interferon-I^, interleukin-6 and transforming growth factor-I^1 gene with oral lichen planus susceptibility. ( 27544215 )
2016
30
Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. ( 27633647 )
2016
31
Immunohistochemical Expression of Stromelysin-2 (St-2) In Patients with Oral Lichen Planus and Its Clinical Significance. ( 27840837 )
2016
32
Allelic loss in amalgam-associated oral lichenoid lesions compared to oral lichen planus and mucosa. ( 28028908 )
2016
33
Usefulness of micro-biopsy in the follow-up of oral lichen planus. ( 27580656 )
2016
34
Oral lichen planus: therapy and phenotype. ( 27982545 )
2016
35
Epidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study. ( 27051650 )
2016
36
Hematinic deficiencies and anemia statuses in antigastric parietal cell antibody-positive erosive oral lichen planus patients with desquamative gingivitis. ( 27511590 )
2016
37
Molecular markers in oral lichen planus: A systematic review. ( 27194873 )
2016
38
Simultaneous gingival squamous cell carcinoma in an oral lichen planus patient. ( 27175452 )
2016
39
Total glucosides of paeony (TGP) inhibits the production of inflammatory cytokines in oral lichen planus by suppressing the NF-I_B signaling pathway. ( 27107800 )
2016
40
Buccal Micronuclei Assay as a Tool For Biomonitoring DNA Damage in Oral Lichen Planus. ( 27630941 )
2016
41
Different Expression of MicroRNA-146a in Peripheral Blood CD4(+) T Cells and Lesions of Oral Lichen Planus. ( 26861135 )
2016
42
Food allergen-mediated exacerbations of oral lichen planus. ( 27663157 )
2016
43
Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. ( 27113338 )
2016
44
Oral Lichen Planus Treated With Apremilast. ( 27538007 )
2016
45
Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report. ( 27920651 )
2016
46
Relation Between Periodontal Status and Pre-Cancerous Condition (Oral Lichen Planus): A Pilot Study. ( 27629852 )
2016
47
Hepatitis C and Oral Lichen Planus: Evaluation of their Correlation and Risk Factors in a Longitudinal Clinical Study. ( 27084859 )
2016
48
CLA and CD62E expression in oral lichen planus lesions. ( 26332489 )
2016
49
Survivin expression in oral lichen planus: Role in malignant transformation. ( 27601815 )
2016
50
To estimate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with symptomatic oral lichen planus. ( 27134451 )
2016

Variations for Oral Lichen Planus

Expression for Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for Oral Lichen Planus

Pathways related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CASP3 CCL5 CCR5 CD58 HSPA8 ICAM1
2
Show member pathways
13.26 CASP3 CCL5 CCR5 CXCR3 ICAM1 MMP1
3
Show member pathways
13.25 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
4
Show member pathways
13.09 BAX CASP3 CCL5 CCR5 CXCR3 IL1A
5
Show member pathways
13.03 CASP3 CCL5 CCR5 HSPA8 ICAM1 IL1A
6
Show member pathways
12.72 CASP3 HSPA8 HSPD1 ICAM1 IL1A
7
Show member pathways
12.66 CASP3 CCL5 HSPA8 ICAM1 IL1A
8
Show member pathways
12.6 CASP3 ICAM1 MMP1 TIMP2 VCAM1
9
Show member pathways
12.1 CASP3 CCR5 HSPA8 IL1A
10 12.06 BAX CASP3 HSPD1 IL1A
11 12.02 BAX CASP3 MMP1
12 11.98 CD58 ICAM1 VCAM1
13 11.96 ICAM1 IL1A VCAM1
14
Show member pathways
11.9 BAX CASP3 TP63
15
Show member pathways
11.89 CCL5 CCR5 CXCR3
16 11.87 CASP3 ICAM1 IL1A
17 11.74 CASP3 CCL5 ICAM1 VCAM1
18
Show member pathways
11.7 BAX CASP3 VCAM1
19 11.69 BAX ICAM1 MMP1
20 11.62 CCL5 ICAM1 IL1A MMP1
21 11.45 CASP3 HSPA8 HSPD1
22 11.41 HSPA8 ICAM1 IL1A MMP1 VCAM1
23
Show member pathways
11.36 ICAM1 IL1A MMP1 VCAM1
24 11.33 BAX CASP3 MMP1
25 11.22 CCL5 MMP1 TIMP2
26 11.15 BAX CCL5 IL1A
27 11.15 CCL5 CCR5 ICAM1 IL1A
28 11.06 ICAM1 TIMP2
29 11.02 BAX CASP3 ICAM1 IL1A VCAM1
30 11.01 BAX CASP3
31
Show member pathways
10.98 BAX TP63
32 10.85 CCL5 MMP1
33 10.82 ICAM1 VCAM1

GO Terms for Oral Lichen Planus

Cellular components related to Oral Lichen Planus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.56 HSPA8 HSPD1 MMP1 TIMP2
2 extracellular space GO:0005615 9.5 CCL5 HSPA8 HSPD1 ICAM1 IL1A TIMP2
3 external side of plasma membrane GO:0009897 9.46 CCR5 CXCR3 ICAM1 VCAM1
4 cell surface GO:0009986 9.17 CCR5 CD58 CXCR3 HSPD1 ICAM1 TIMP2

Biological processes related to Oral Lichen Planus according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL5 CCR5 CXCR3 IL1A
2 response to drug GO:0042493 9.89 CASP3 HSPD1 ICAM1 TIMP2
3 chemotaxis GO:0006935 9.83 CCL5 CCR5 CXCR3
4 response to organic cyclic compound GO:0014070 9.81 CASP3 HSPD1 ICAM1
5 response to lipopolysaccharide GO:0032496 9.8 CASP3 HSPD1 ICAM1 VCAM1
6 single organismal cell-cell adhesion GO:0016337 9.77 CD58 ICAM1 VCAM1
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.73 BAX CASP3 HSPD1
8 response to hypoxia GO:0001666 9.73 CASP3 HSPD1 ICAM1 VCAM1
9 chemokine-mediated signaling pathway GO:0070098 9.71 CCL5 CCR5 CXCR3
10 cellular response to interferon-gamma GO:0071346 9.69 CCL5 CD58 ICAM1
11 regulation of neuron apoptotic process GO:0043523 9.65 BAX TP63
12 apoptotic mitochondrial changes GO:0008637 9.65 BAX HSPD1
13 response to ionizing radiation GO:0010212 9.65 BAX ICAM1 VCAM1
14 response to X-ray GO:0010165 9.64 CASP3 TP63
15 B cell homeostasis GO:0001782 9.64 BAX CASP3
16 dendritic cell chemotaxis GO:0002407 9.62 CCL5 CCR5
17 response to copper ion GO:0046688 9.62 ICAM1 IL1A
18 protein refolding GO:0042026 9.61 HSPA8 HSPD1
19 positive regulation of protein oligomerization GO:0032461 9.58 BAX MMP1
20 chaperone mediated protein folding requiring cofactor GO:0051085 9.58 HSPA8 HSPD1
21 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.57 BAX TP63
22 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.55 BAX CASP3
23 neuron apoptotic process GO:0051402 9.54 BAX CASP3 TP63
24 ectopic germ cell programmed cell death GO:0035234 9.52 BAX IL1A
25 cellular response to organic substance GO:0071310 9.5 BAX CASP3 ICAM1
26 membrane to membrane docking GO:0022614 9.46 ICAM1 VCAM1
27 cellular response to tumor necrosis factor GO:0071356 9.46 CCL5 CD58 ICAM1 VCAM1
28 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 BAX CASP3 IL1A
29 adhesion of symbiont to host GO:0044406 9.4 HSPD1 ICAM1
30 viral process GO:0016032 9.17 BAX CCR5 HSPA8 HSPD1 ICAM1 MMP1
31 leukocyte cell-cell adhesion GO:0007159 9.13 CCL5 ICAM1 VCAM1
32 apoptotic process GO:0006915 10 BAX CASP3 CXCR3 IL1A TP63

Molecular functions related to Oral Lichen Planus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine receptor activity GO:0004950 9.16 CCR5 CXCR3
2 integrin binding GO:0005178 9.13 ICAM1 TIMP2 VCAM1
3 protease binding GO:0002020 8.8 CASP3 HSPD1 TIMP2

Sources for Oral Lichen Planus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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