MCID: ORL013
MIFTS: 34

Oral Lichen Planus malady

Oral diseases category

Summaries for Oral Lichen Planus

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Oral lichen planus is a inflammatory condition that affects the inside of the mouth.  signs and symptoms include patches of fine white lines and dots most commonly in the inside of the cheeks, gums, and/or tongue. most people with lichen planus experience no to few symptoms, others may have painful sores or ulcers in the mouth. severe lichen planus slightly increases the risk for oral cancer. oral lichen planus may occur alone or in combination with other skin forms of lichen planus. last updated: 7/20/2011

MalaCards: Oral Lichen Planus, also known as oral lichenoid lesions, is related to lichen planus and hepatitis. An important gene associated with Oral Lichen Planus is CD207 (CD207 molecule, langerin), and among its related pathways are MicroRNAs in cancer and Cytoskeleton remodeling Keratin filaments. The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include skin and tongue, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Oral Lichen Planus

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

oral lichen planus 42
oral lichenoid lesions 42
lichen planus, oral 60
lichen planus oral 44


Related Diseases for Oral Lichen Planus

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17GeneCards, 18GeneDecks
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Diseases related to Oral Lichen Planus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1lichen planus32.3KRT10, KRT16, KRT1, KRT13
2hepatitis31.4CEACAM1
3squamous cell carcinoma31.2KRT15, KRT16, KRT1, KRT13, KRT10, CEACAM1
4papilloma30.6KRT13, KRT10
5alopecia30.3KRT15
6sarcoidosis30.3CCL5, CD27
7hepatitis c10.9
8lichen disease10.9
9gingivitis10.7
10periodontitis10.7
11burns10.5
12burning mouth syndrome10.5
13pemphigus10.5
14hepatitis a10.5
15stomatitis10.5
16thyroiditis10.5
17aphthous stomatitis10.4
18verrucous carcinoma10.4
19thymoma10.4
20crohn's disease10.2
21bullous pemphigoid10.2
22systemic lupus erythematosus10.2
23good syndrome10.2
24vulvovaginitis10.2
25hepatitis b10.2
26oral candidiasis10.2
27vitiligo10.2
28scurvy10.2
29alopecia areata10.2
30candidiasis10.2
31cheilitis10.2
32glossitis10.2
33herpes simplex10.2
34hypothyroidism10.2
35lupus erythematosus10.2
36myasthenia gravis10.2
37viral hepatitis10.2
38oral submucous fibrosis10.1
39psoriasis10.0KRT13, KRT16, KRT1, KRT10, KRT15, CCL5
40melanoma10.0CD27, CD274, CD1A, CEACAM1, CD83, CD68
41hepatocellular carcinoma10.0KRT1, KRT13, CEACAM1, CCL5, CCR1
42asthma10.0CD1A, CCL5, CCR1
43cholesteatoma10.0KRT13, KRT16, KRT10
44epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16
45sarcoma10.0CD207, CD1A
46bowen syndrome10.0KRT16, KRT1, KRT10
47palmoplantar keratosis10.0KRT10, KRT16, KRT1
48epidermolytic acanthoma10.0KRT1
49nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1, KRT16
50rheumatoid arthritis10.0CCL5, CD27, CD274, CD68, CCR1

Graphical network of the top 20 diseases related to Oral Lichen Planus:



Diseases related to oral lichen planus

Clinical Features for Oral Lichen Planus

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Drugs & Therapeutics for Oral Lichen Planus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Oral Lichen Planus

Search NIH Clinical Center for Oral Lichen Planus

Search CenterWatch for Oral Lichen Planus

Genetic Tests for Oral Lichen Planus

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Anatomical Context for Oral Lichen Planus

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Sources:
32MalaCards
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MalaCards organs/tissues related to Oral Lichen Planus:

32
Skin, Tongue

Animal Models for Oral Lichen Planus or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Oral Lichen Planus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.6CCR1, CD68, CD274, CD207, CD27, CD83
2MP:000538710.3CEACAM1, CCL5, CCR1, CD68, CD274, CD207

Publications for Oral Lichen Planus

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Genetic Variations for Oral Lichen Planus

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Expression for genes affiliated with Oral Lichen Planus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Lichen Planus

Search GEO for disease gene expression data for Oral Lichen Planus.

Pathways for genes affiliated with Oral Lichen Planus

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Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Oral Lichen Planus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6MIR203, MIR27B, MIR137, MIR146A, MIR21
210.5KRT16, KRT1, KRT13
310.5MIR203, MIR27B, MIR21

Compounds for genes affiliated with Oral Lichen Planus

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Oral Lichen Planus according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.9CEACAM1, CCL5, CCR1, KRT16, KRT1, KRT13
2paraffin4410.8CD68, CD83, KRT16, KRT1, KRT13, KRT10
3proline4410.8KRT10, KRT13, KRT1, KRT16, CCL5
4calcipotriol44 59 28 1113.8KRT15, KRT10, KRT16
5isotretinoin44 1111.8KRT16, KRT1, KRT10
6calcitriol44 59 11 2413.7CCL5, CD83, KRT16, KRT10
7dithranol4410.7KRT10, KRT16
8calcium44 49 11 2413.6CCL5, CCR1, CD207, CD27, KRT1, KRT13
9tazarotene44 1111.6KRT10, KRT1
10serine4410.6CCL5, CCR1, KRT16, KRT1
11tyrosine4410.6CEACAM1, KRT15, KRT10, KRT1, FCAR, CCR1
12dexamethasone44 49 28 1113.4CCR1, CCL5
13mdms4410.2CCL5, CCR1

GO Terms for genes affiliated with Oral Lichen Planus

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Sources:
16Gene Ontology
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Cellular components related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6CEACAM1, FCAR, CD83, CD27, CD1A, CCR1
2external side of plasma membraneGO:00989710.5CD83, CD27, CD274, CCR1
3keratin filamentGO:04509510.4KRT10, KRT13, KRT1
4intermediate filamentGO:00588210.2KRT16, KRT10, KRT15

Biological processes related to Oral Lichen Planus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00854410.6KRT15, KRT13, KRT16
2positive regulation of monocyte chemotaxisGO:09002610.5CCR1, CCL5
3chemokine-mediated signaling pathwayGO:07009810.5CCR1, CCL5
4dendritic cell chemotaxisGO:00240710.4CCL5, CCR1
5immune responseGO:00695510.2FCAR, CD274, CD1A, CCR1

Products for genes affiliated with Oral Lichen Planus

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Oral Lichen Planus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet