Aliases & Classifications for Oral Mucosa Leukoplakia

MalaCards integrated aliases for Oral Mucosa Leukoplakia:

Name: Oral Mucosa Leukoplakia 12 14
Leukoplakia of Buccal Mucosa 69
Leukoplakia, Oral 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9655
ICD10 33 K13.2 K13.21
ICD9CM 35 528.6
UMLS 69 C1112530

Summaries for Oral Mucosa Leukoplakia

MalaCards based summary : Oral Mucosa Leukoplakia, also known as leukoplakia of buccal mucosa, is related to asthma and senile cataract, and has symptoms including enanthema and oral mucosal blisters. An important gene associated with Oral Mucosa Leukoplakia is GSTP1 (Glutathione S-Transferase Pi 1), and among its related pathways/superpathways is Fluid shear stress and atherosclerosis. The drugs Aminolevulinic acid and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Oral Mucosa Leukoplakia

Diseases related to Oral Mucosa Leukoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 asthma 9.5 EDN1 GSTP1
2 senile cataract 9.4 EDN1 GSTP1
3 acute proliferative glomerulonephritis 9.2 EDN1 GSTP1

Symptoms & Phenotypes for Oral Mucosa Leukoplakia

UMLS symptoms related to Oral Mucosa Leukoplakia:


enanthema, oral mucosal blisters

GenomeRNAi Phenotypes related to Oral Mucosa Leukoplakia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.4 GSTP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.4 GSTP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.4 GSTP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.4 EDN1 GSTP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.4 EDN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.4 GSTP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.4 EDN1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.4 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.4 EDN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.4 EDN1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.4 GSTP1

Drugs & Therapeutics for Oral Mucosa Leukoplakia

Drugs for Oral Mucosa Leukoplakia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 3,Phase 1 106-60-5 137
2 Dermatologic Agents Phase 3,Phase 1
3 Photosensitizing Agents Phase 3,Phase 1
4
Fenretinide Investigational Phase 2 65646-68-6
5 Retinamide Phase 2
6 Tea Nutraceutical Phase 2
7
Nicotine Approved 54-11-5 942 89594
8 Autonomic Agents
9 Central Nervous System Stimulants
10 Cholinergic Agents
11 Neurotransmitter Agents
12 Nicotinic Agonists
13 Peripheral Nervous System Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Oral Precursor Lesions Completed NCT01497951 Phase 3
2 Fenretinide in Treating Patients With Leukoplakia of the Mouth Completed NCT00004161 Phase 2 fenretinide;Placebo
3 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
4 Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia Terminated NCT00571558 Phase 1 aminolevulinic acid hydrochloride;photodynamic therapy
5 Least Invasive Nonlinear Light Microscopy Unknown status NCT00767442
6 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544
7 Biomarkers for Oral Cancer Completed NCT00341497
8 Clinical Research Core Dental Screening Protocol Completed NCT00090818
9 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
10 Tobacco Cessation Intervention Study for Oral Diseases Recruiting NCT02737176

Search NIH Clinical Center for Oral Mucosa Leukoplakia

Genetic Tests for Oral Mucosa Leukoplakia

Anatomical Context for Oral Mucosa Leukoplakia

MalaCards organs/tissues related to Oral Mucosa Leukoplakia:

39
Tongue

Publications for Oral Mucosa Leukoplakia

Variations for Oral Mucosa Leukoplakia

Expression for Oral Mucosa Leukoplakia

Search GEO for disease gene expression data for Oral Mucosa Leukoplakia.

Pathways for Oral Mucosa Leukoplakia

Pathways related to Oral Mucosa Leukoplakia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.77 EDN1 GSTP1

GO Terms for Oral Mucosa Leukoplakia

Biological processes related to Oral Mucosa Leukoplakia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to amino acid GO:0043200 9.16 EDN1 GSTP1
2 cellular response to glucocorticoid stimulus GO:0071385 8.96 EDN1 GSTP1
3 negative regulation of nitric-oxide synthase biosynthetic process GO:0051771 8.62 EDN1 GSTP1

Sources for Oral Mucosa Leukoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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