Oral Squamous Cell Carcinoma malady

MalaCards: Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma, is related to carcinoma and prostatitis. An important gene associated with Oral Squamous Cell Carcinoma is HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), and among its related pathways are Pancreatic Adenocarcinoma and Paxillin Interactions. The drugs bleomycin sulfate and bleomycin and the compounds calcium and paraffin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and nk cells, and related mouse phenotypes are mortality/aging and cellular.

oral squamous cell carcinoma 30 squamous cell carcinoma 43

Diseases related to oral squamous cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 923)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	98.1	ZNF510, PIK3CA, PIDD, PIK3C2A, PIN1, PIM1
2	prostatitis	65.3	PIK3CA, PIK3C2A, PIN1, PIM1, LRP1B, PDCD1
3	leukemia	62.0	PIK3CA, PIK3C2A, PIN1, PIM1, PDCD1, PDCD1LG2
4	hepatocellular carcinoma	61.0	PIK3CA, PIN1, PDCD1, PDCD1LG2, PDCD4, RECK
5	adenocarcinoma	61.0	PIK3CA, PIK3C2A, PIN1, PIM1, RECK, VTN
6	cervicitis	60.8	PIK3CA, PIN1, PDCD1, PDCD1LG2, PDCD4, RECK
7	pancreatitis	60.5	PIK3CA, PIK3C2A, PIN1, PIM1, PDCD1LG2, RECK
8	melanoma	59.8	PIK3CA, PIK3C2A, PIM1, PDCD1, PDCD1LG2, RECK
9	esophageal squamous cell carcinoma	59.3	PIK3CA, PIN1, PIM1, LRP1B, RECK, SFN
10	esophagitis	58.3	PIK3CA, PIK3C2A, PIN1, PIM1, LRP1B, PDCD1LG2
11	neuronitis	56.3	PIK3CA, PIK3C2A, PIN1, PIM1, RECK, SFN
12	gastric cancer	56.3	PIK3CA, PIN1, PIM1, LRP1B, PDCD4, RECK
13	thyroiditis	54.2	PIK3CA, PIK3C2A, PIN1, LRP1B, RECK, VTN
14	laryngitis	53.9	PIK3CA, PIM1, PDCD4, SFN, PCNA, RB1
15	breast carcinoma	53.4	PIK3CA, RECK, VTN, SFN, SFRP1, PCNA
16	cervical cancer	52.2	PIK3CA, PIN1, PDCD1, VTN, SFN, SFRP1
17	lung carcinoma	51.6	PIK3CA, LRP1B, RECK, PCNA, BUB1B, RB1
18	laryngeal squamous cell carcinoma	50.7	PIM1, SFN, PCNA, RB1, BSG, VEGFA
19	hypoxia	49.8	PIK3CA, PIK3C2A, PIM1, PDCD4, RECK, VTN
20	squamous cell carcinoma of the head and neck	48.2	PIK3CA, VTN, PCNA, SELE, BRAF, VEGFA
21	squamous cell carcinoma	47.3	SERPINB3, SERPINB4, LGALS1, CD44, CDH1, MMP7
22	sarcoma	45.6	PIK3CA, PIK3C2A, RECK, VTN, PCNA, RB1
23	cervical carcinoma	44.0	PIK3CA, PDCD1, PDCD1LG2, RECK, VTN, PCNA
24	lung adenocarcinoma	43.9	PIK3CA, PCNA, RB1, RBL2, SELE, SETD2
25	retinoblastoma	43.5	PIK3CA, RECK, SFRP2, PCNA, RB1, RBL2
26	nasopharyngitis	43.4	PIK3CA, PDCD1, RECK, SFN, SFRP2, PCNA
27	cervical squamous cell carcinoma	43.4	SERPINB3, SERPINB4, BSG, MYC, BIRC5, BCL2
28	fibrosis	43.2	PIK3CA, PIN1, RECK, VTN, PCNA, SELE
29	esophageal cancer	42.9	PIK3CA, PDCD1LG2, PDCD4, SFRP1, PCNA, RB1
30	oral cancer	42.4	RECK, SFN, SFRP1, SFRP2, SFRP5, PCNA
31	rheumatoid arthritis	41.9	PIN1, PDCD1, PDCD1LG2, RECK, VTN, SFRP1
32	leukoplakia	41.8	PCNA, RARA, RARB, BCL2, CHKA, BAG1
33	keratoacanthoma	41.4	PCNA, BCL2, BCL2L1, MUC1, BAK1, MSH2
34	lymphocytic leukemia	40.8	PIK3CA, PDCD1LG2, RECK, SFN, SFRP1, SFRP2
35	basal cell carcinoma	40.1	VDR, RARA, BCL2, LGALS1, BAK1, BAX
36	esophageal carcinoma	39.9	PCNA, RB1, RBL2, SERPINB5, VEGFA, VEGFC
37	myeloma	39.5	PIK3CA, RECK, VTN, SFRP1, SFRP2, SFRP5
38	psoriasis	39.4	VTN, PCNA, SELE, SERPINB3, SERPINF2, VIM
39	thyroid carcinoma	39.2	PIK3CA, SFN, PCNA, RB1, SELE, SERPINB3
40	pharyngitis	39.0	PIK3CA, PCNA, RBL2, VIM, VEGFA, VDR
41	basaloid squamous cell carcinoma	38.9	PCNA, MYC, BIRC5, BCL2L1, BAX, CDKN1B
42	cervical intraepithelial neoplasia	38.8	PIK3CA, PCNA, RB1, VEGFA, VEGFC, BMP6
43	actinic keratosis	38.4	PCNA, RB1, LMNA, MYC, BCL2, S100A2
44	papilloma	38.2	PIN1, PCNA, RB1, RBL2, SERPINB3, VIM
45	laryngeal carcinoma	38.0	PDCD4, PCNA, RB1, SERPINB5, BSG, VEGFA
46	laryngeal cancer	37.7	PCNA, RB1, SERPINB3, BSG, VEGFA, VEGFC
47	gingivitis	37.6	PCNA, SELE, SETD2, SERPINF2, SERPINF1, SERPINE1
48	keratosis	37.6	PIK3CA, PCNA, RB1, LMNA, MYC, BCL2
49	teratoma	37.5	PCNA, VIM, NANOG, BCL2, CHEK2, BAX
50	small cell carcinoma	37.5	PCNA, RB1, VIM, VEGFA, BCL2, CHKA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate

MalaCards organs/tissues related to oral squamous cell carcinoma:

²²

MGI Mouse Phenotypes related to oral squamous cell carcinoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	26.2	PIK3CA, PIK3C2A, PDCD1, PDCD1LG2, PDCD4, RECK
2	cellular phenotype	MP:0005384	24.8	PIK3CA, PIN1, PIM1, PDCD1, PDCD1LG2, SFN
3	growth/size phenotype	MP:0005378	24.1	PIK3CA, PIK3C2A, PIN1, PIM1, RECK, SFN
4	homeostasis/metabolism phenotype	MP:0005376	21.3	PIK3CA, PIK3C2A, PDCD1LG2, VTN, SFRP1, SFRP2
5	nervous system phenotype	MP:0003631	20.8	PDCD1, RECK, SFRP1, SFRP2, SFRP5, RB1
6	hematopoietic system phenotype	MP:0005397	20.2	PIM1, PDCD1, PDCD1LG2, SFN, SFRP1, PCNA
7	integument phenotype	MP:0010771	19.2	PIN1, RECK, SFN, BUB1B, RB1, RBL2
8	immune system phenotype	MP:0005387	19.0	PDCD4, SFN, SFRP1, BUB1B, SERPINE2, VIM
9	cardiovascular system phenotype	MP:0005385	18.9	PIK3CA, PDCD1, RECK, SFRP1, SFRP2, RB1
10	digestive/alimentary phenotype	MP:0005381	18.6	SFN, RB1, SERPINF1, BRAF, VHL, VEGFA
11	embryogenesis phenotype	MP:0005380	18.3	PIK3CA, RECK, SFN, SFRP1, SFRP2, SFRP5
12	behavior/neurological phenotype	MP:0005386	17.7	PIK3CA, RB1, SELE, SERPINE2, VIM, BRAF
13	normal phenotype	MP:0002873	17.3	PIDD, LRP1B, VTN, SFRP2, SFRP5, RBL2
14	skeleton phenotype	MP:0005390	16.7	RECK, SFN, SFRP1, BUB1B, RB1, RBL2
15	reproductive system phenotype	MP:0005389	15.8	PIK3CA, PDCD4, SFN, SFRP2, SFRP5, BUB1B
16	tumorigenesis	MP:0002006	15.6	PIK3CA, PDCD1LG2, PDCD4, SFN, BUB1B, RB1
17	renal/urinary system phenotype	MP:0005367	15.6	PDCD1, PDCD4, BRAF, VHL, LMNA, VAV2
18	vision/eye phenotype	MP:0005391	15.6	PIK3CA, PIN1, PDCD1, SFN, BUB1B, RB1
19	limbs/digits/tail phenotype	MP:0005371	15.5	RECK, SFN, SFRP1, SFRP2, SFRP5, RB1
20	no phenotypic analysis	MP:0003012	15.3	PDCD1LG2, SFRP1, SFRP2, PCNA, RB1, RBL2
21	muscle phenotype	MP:0005369	14.6	PIK3CA, PDCD1, SFRP2, BUB1B, RB1, RBL2
22	hearing/vestibular/ear phenotype	MP:0005377	13.4	SFN, RB1, VDR, LMNA, MYC, BMP2
23	pigmentation phenotype	MP:0001186	13.0	RB1, SERPINF1, BRAF, LMNA, MYC, BMP7
24	endocrine/exocrine gland phenotype	MP:0005379	12.9	PDCD4, SFN, SFRP2, SFRP5, RBL2, SERPINE2
25	other phenotype	MP:0005395	12.2	RECK, RARA, RARB, KDR, LAMC2, AXIN1
26	adipose tissue phenotype	MP:0005375	11.5	PIK3CA, PIK3C2A, SFRP1, BUB1B, RB1, SERPINE1
27	liver/biliary system phenotype	MP:0005370	11.5	RECK, SFN, VHL, VEGFA, RASSF2, CHKA
28	respiratory system phenotype	MP:0005388	10.7	TP63

Articles related to oral squamous cell carcinoma:

(show top 50)    (show all 912)

id	Title	Authors	Year	Affiliating Genes
1	Overexpression of a chromatin remodeling factor, RSF- 1/HBXAP, correlates with aggressive oral squamous cell carcinoma. (21514451)	Fang F.M.... Sheu J.J.	2011	RSF1
2	Analysis of methylation patterns and expression profi les of p14ARF gene in patients with oral squamous cell carcinoma. (20586029)	Kordi-Tamandani D.M.... Torkamanzehi A.	2010	CDKN2A
3	Laminin-derived peptide AG73 regulates migration, inv asion, and protease activity of human oral squamous cell carcinoma cells throug h syndecan-1 and beta1 integrin. (20237901)	Siqueira A.S.... Jaeger R.G.	2010	ITGB1, SDC1, LAMA1
4	Tumor-specific mutation and downregulation of ING5 de tected in oral squamous cell carcinoma. (20131318)	Cengiz B.... Nagatsuka H.	2010	ING5
5	Increased expression of Cathepsin B in oral squamous cell carcinoma. (20042316)	Yang X.... Zhang Z.Y.	2010	CTSB
6	Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations. (20393745)	Kreppel M.... ZAPller J.E.	2010	PDPN
7	Functional significance of TGF-beta1 signal transduc tion pathway in oral squamous cell carcinoma (19538865)	Wang X.M.... Fu S.B.	2009	TGFBR2, TGFB1, SMAD4
8	High-risk human papillomavirus (HPV) is not associate d with p53 and bcl-2 expression in oral squamous cell carcinomas. (19124208)	Oliveira M.C.... Costa A.d.e. .L.	2009	BCL2
9	Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. (18952491)	Chang H.H.... Chiang C.P.	2009	BCL10
10	The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: immunohistochemical and RT-PCR analysis with clinicopathological correlation. (19327640)	Wang X.... Chen X.	2009	CDH1
11	Endoglin (CD105) and microvessel density in oral squamous cell carcinoma. (18758636)	Margaritescu C.... Ciurea R.	2008	ENG
12	P21/ WAF1 and cyclin D1 variants and oral squamous cell carcinoma. (18251939)	Gomes C.C.... Gomez R.S.	2008	CCND1, CDKN1A
13	Expression of chemokine receptor-7 in oral squamous cell carcinoma and its relation to cervical lymph node metastasis (19087620)	Shang Z.J.... Chen X.M.	2008	CCR7
14	Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma. (18460737)	Ye H.... Zhou X.	2008	SOD2
15	Relationship between soluble MICA and the MICA A5.1 homozygous genotype in patients with oral squamous cell carcinoma. (18951065)	Tamaki S.... Kirita T.	2008	HLA-A, KLRK1, MICA
16	beta-catenin expression pattern in primary oral squamous cell carcinoma. (19080115)	Cai Z.G.... Yu G.Y.	2008	CTNNB1
17	Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma. (18636111)	Ogiuchi Y.... Ogiuchi H.	2008	TYMS, UMPS, TYMP
18	The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma. (18097553)	Miyazaki Y.... Shibata T.	2008	HIF1A
19	Cross-reactivity between Candida albicans and oral squamous cell carcinoma revealed by monoclonal antibody C7. (17972529)	Rodriguez M.J.... Aguirre J.M.	2007	NUP88
20	Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. (16798059)	Chen H.H.... Chiang C.P.	2007	TERT
21	Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma. (17499344)	Oliveira L.R.... Zucoloto S.	2007	TP53, TP63
22	Tumor-specific genetic expression profile of metastatic oral squamous cell carcinoma. (17573689)	Mendez E.... Chen C.	2007	TGM3
23	Increased expression and activation of matrix metalloproteinase-2 (MMP-2) in O-1N: hamster oral squamous cell carcinoma with high potential lymph node metastasis. (17167983)	Zhang Y.... Jinbu Y.	2006	MMP2
24	Increased survivin expression in high-grade oral squamous cell carcinoma: a study in Indian tobacco chewers. (17032391)	Jane C.... Karjodkar F.R.	2006	TP53, BIRC5
25	Identification of genes associated with cisplatin res istance in human oral squamous cell carcinoma cell line. (16978399)	Zhang P.... Chen W.	2006	CCND3
26	Relative quantification of cytokeratin 19 transcription in oral squamous cell carcinoma tissues by fluorescent quantitive real-time RT-PCR (17129430)	Zhong L.P.... Chen G.F.	2006	KRT19
27	Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. (16676365)	Liu C.J.... Chang K.W.	2006	EGR2, TRIM24
28	PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. (17052259)	Kozaki K.... Inazawa J.	2006	PIK3CA
29	Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas. (15668483)	Mustafa T.... Hoang-Vu C.	2005	CD97
30	Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8. (16273203)	Harada K.... Sato M.	2005	VEGFA, IL8
31	Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. (15767248)	Henson B.S.... D'Silva N.J.	2005	GALR1
32	Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma. (15226771)	Gao S.... Dabelsteen E.	2004	DBC1
33	Assessment of p63 expression in oral squamous cell carcinomas and dysplasias. (15583543)	Bortoluzzi M.C.... Regezi J.A.	2004	TP63
34	Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection; results of EORTC Translational Research Fund studies. (14962715)	Oliver R.J.... Airley R.E.	2004	SLC2A1
35	Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas. (14707456)	Shintani S.... Hamakawa H.	2003	CDKN1B, SKP2, COPS5
36	Cyclin D1 genotype in areca-associated oral squamous cell carcinoma. (12694349)	Wong Y.K.... Chang K.W.	2003	CCND1
37	Immunohistochemical study of sialyl Lewis(a) antigen in oral squamous cell carcinoma: the association of sialyl Lewis(a) expression with local lymph metastasis (14732974)	Wu L.... Huang W.	2003	SELE
38	Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin. (12509969)	Miyashita H.... Takebayashi Y.	2003	ATP7B
39	High concentration of beta-defensin-2 in oral squamous cell carcinoma. (12174890)	Sawaki K.... Sugahara T.	2002	DEFB4A
40	Thymidine phosphorylase expression in oral squamous cell carcinoma. (12167436)	Yao L.... Furuta I.	2002	TYMP
41	MET receptor is overexpressed but not mutated in oral squamous cell carcinomas. (11748586)	Morello S.... Giordano S.	2001	MET
42	Salivary oncofoetal fibronectin and oral squamous cell carcinoma. (10890557)	Lyons A.J.... Cui N.	2000	FN1
43	Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential. (10745174)	Hong S.D.... Lim C.Y.	2000	MMP2, MMP9
44	Correlation of E-cadherin and alpha-catenin expression with differentiation of oral squamous cell carcinoma. (10863478)	Sakaki T.... Sakaki T.	1999	CDH1, CTNNA1
45	p53, PCNA and Ki-67 expression in oral squamous cell carcinomas: the vagaries of fixation and microwave enhancement of immunocytochemistry. (9790097)	Allison R.T.... Best T.	1998	PCNA
46	Relationship of p53 overexpression to other cell cycle regulatory proteins in oral squamous cell carcinoma. (9736426)	Warnakulasuriya K.A.... Johnson N.W.	1998	TP53
47	A general review of the p53 gene and oral squamous cell carcinoma. (10895614)	Jones A.	1998	TP53
48	P53 expression and clinical significance in oral squamous cell carcinoma (11480024)	Long Y.... Yue W.	1997	TP53
49	Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions. (8835820)	Matsuda H.... Sugimura M.	1996	TP53
50	Loss of epithelial L1 expression is associated with cellular invasion of oral squamous cell carcinomas. (1381755)	Heyden A.... Brandtzaeg P.	1992	KRT13

Genes related to oral squamous cell carcinoma according to GeneCards:

(show top 50)    (show all 590)

id	Symbol	Description	Score	GeneCards Section Context
1	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.1	Publications, Summaries
2	RBMXP1	RNA binding motif protein, X-linked pseudogene 1	11.0	Publications
3	MIR124-2	microRNA 124-2	11.0	Publications
4	MIR124-3	microRNA 124-3	11.0	Publications
5	MIR181A1	microRNA 181a-1	11.0	Publications
6	MIR181A2	microRNA 181a-2	11.0	Publications
7	DEFB103A	defensin, beta 103A	11.0	Publications
8	MAGEA5	melanoma antigen family A, 5	11.0	Publications
9	MIR124-1	microRNA 124-1	11.0	Publications
10	GPR87	G protein-coupled receptor 87	11.0	Publications
11	SPINK7	serine peptidase inhibitor, Kazal type 7 (putative)	11.0	Publications
12	HOXB5	homeobox B5	11.0	Publications
13	MAGEA6	melanoma antigen family A, 6	11.0	Publications
14	MIA	melanoma inhibitory activity	11.0	Publications
15	ORAOV1	oral cancer overexpressed 1	11.0	Publications
16	CDK2AP1	cyclin-dependent kinase 2 associated protein 1	11.0	Publications
17	CRNN	cornulin	11.0	Expressions, Publications
18	MAGEA12	melanoma antigen family A, 12	11.0	Publications
19	CKS1B	CDC28 protein kinase regulatory subunit 1B	11.0	Publications
20	CD37	CD37 molecule	11.0	Publications
21	CKMT1B	creatine kinase, mitochondrial 1B	11.0	Publications
22	FAM215A	family with sequence similarity 215, member A (non-protein coding)	11.0	Publications
23	GSDMB	gasdermin B	11.0	Publications, UniProt Related
24	HOXA7	homeobox A7	11.0	Publications
25	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	11.0	Publications
26	ITPKA	inositol-trisphosphate 3-kinase A	11.0	Publications
27	KRT13	keratin 13	11.0	Publications
28	KRT4	keratin 4	11.0	Publications
29	LZTS1	leucine zipper, putative tumor suppressor 1	11.0	Publications
30	MAGEA2	melanoma antigen family A, 2	11.0	Publications
31	MDK	midkine (neurite growth-promoting factor 2)	11.0	Publications
32	NNMT	nicotinamide N-methyltransferase	11.0	Publications
33	PA2G4	proliferation-associated 2G4, 38kDa	11.0	Publications
34	PCNP	PEST proteolytic signal containing nuclear protein	11.0	Publications
35	PIDD	p53-induced death domain protein	11.0	Publications
36	RIN1	Ras and Rab interactor 1	11.0	Publications
37	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
38	SFRP5	secreted frizzled-related protein 5	11.0	Publications
39	SPA17	sperm autoantigenic protein 17	11.0	Publications
40	WIBG	within bgcn homolog (Drosophila)	11.0	Publications
41	CCNE2	cyclin E2	11.0	Publications
42	CENPH	centromere protein H	11.0	Publications
43	CLDN7	claudin 7	11.0	Publications
44	DEFB103B	defensin, beta 103B	11.0	Publications
45	MMP28	matrix metallopeptidase 28	11.0	Publications
46	PGAM1	phosphoglycerate mutase 1 (brain)	11.0	Publications
47	PITX1	paired-like homeodomain 1	11.0	Publications
48	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.0	Publications
49	UPP1	uridine phosphorylase 1	11.0	Publications
50	ZIC1	Zic family member 1	11.0	Publications

Pathways related to oral squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 348)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic Adenocarcinoma36	13.8	RB1, BRAF, VEGFB, VEGFC, BMP2, BMP6
2	Paxillin Interactions36	13.1	VEGFB, VEGFC, VCL, BMP2, RAC1, PAK4
3	Akt Signaling36	13.0	VEGFB, VEGFC, BMP2, BMP7, RAF1, CHUK
4	Cell cycle20	12.8	SFN, PCNA, BUB1B, RB1, RBL2, MYC
5	Adhesion3	12.1	VCL, CLDN1, CEACAM1, JUP, CDH2, CDH3
6	eNOS Signaling36	12.0	BMP2, BMP6, BMP7, FLT4, AREG, FIGF
7	Rho Family GTPases36	12.0	VIM, VEGFB, VEGFC, BMP2, BMP6, BMP7
8	Selected targets of p5310	11.9	SERPINB5, BCL2, BAX, S100A2, CDKN1A, CDK2
9	Cell adhesion_ECM remodeling41	11.9	VTN, SERPINE2, SERPINE1, VCAN, LAMA1, LAMC2
10	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms41	11.8	VTN, LAMA1, JUP, CDH2, ITGA2, ITGA3
11	p53 Mediated Apoptosis36	11.8	VEGFB, VEGFC, BMP2, BMP6, BMP7, KDR
12	Bladder cancer20	11.7	RB1, BRAF, VEGFA, VEGFB, VEGFC, MYC
13	p53 Signaling36	11.7	SFN, BCL2, CHEK2, UBC, BAX, CDKN1A
14	p70S6K Signaling36	11.6	VEGFB, VEGFC, BMP2, BMP6, BMP7, RAF1
15	ErbB2-ErbB3 Heterodimers36	11.6	RAF1, FOXO3, MAPK6, MAP2K3, MAPK7, ETV4
16	Cell adhesion_Plasmin signaling41	11.5	PIK3CA, VEGFA, KDR, LAMA1, XIAP, MMP13
17	ErbB Family Pathway36	11.5	BRAF, RAF1, PAK4, JUN, CDC42, FOS
18	Cell cycle_ESR1 regulation of G1/S transition41	11.5	RB1, RBL2, MYC, CKS1B, UBC, JUN
19	Tec Kinases Signaling36	11.5	VEGFB, VEGFC, VAV2, BMP2, BMP6, BMP7
20	Chemokine signaling pathway20	11.5	PIK3CA, BRAF, VAV2, RAF1, RAC1, CHUK
21	Cytoskeleton remodeling_FAK signaling41	11.4	PIK3CA, VEGFA, RAF1, RAC1, KDR, CDC42
22	14-3-3 Induced Intracellular Signaling36	11.4	VEGFB, VEGFC, BMP2, BMP7, RAF1, YAP1
23	Development_VEGF-family signaling41	11.3	PIK3CA, VTN, VEGFA, VEGFB, VEGFC, RAF1
24	Apoptotic Pathways in Synovial Fibroblasts36	11.3	VEGFB, VEGFC, BMP2, BMP6, BMP7, KDR
25	Cell cycle Regulation of G1/S transition (part 2)10	11.3	RB1, RBL2, CHUK, JUN, CDK6, CDK2
26	TGF-Beta Pathway36	11.2	VEGFB, VEGFC, BMP2, BMP6, BMP7, KDR
27	Development_Thrombopoietin-regulated cell processes41	11.2	PIK3CA, BRAF, MYC, RAF1, RAC1, BIRC5
28	Development ERBB-family signaling10	11.2	MYC, RAF1, CHUK, AREG, MAPK3, HRAS
29	Activation of PKC through GPCR36	11.2	VEGFB, VEGFC, BMP2, BMP6, BMP7, RAF1
30	Development_TGF-beta receptor signaling41	11.1	SERPINE1, RAF1, CHUK, XIAP, CDKN1A, CDKN2B
31	Development_EGFR signaling pathway41	11.0	PIK3CA, MYC, RAF1, RAC1, CHUK, JUN
32	Development Prolactin receptor signaling10	11.0	PIK3CA, VAV2, MYC, RAF1, RAC1, BCL2
33	Activation of cAMP-Dependent PKA36	11.0	VEGFB, VEGFC, BMP2, BMP7, RAF1, KDR
34	VEGF Signaling Pathway34	11.0	PIK3C2A, VEGFA, VEGFB, VEGFC, RAF1, KDR
35	TGF-beta Signaling Pathways37	10.9	BRAF, MYC, RAF1, RAC1, MTOR, JUN
36	IL-2 Pathway36	10.9	MYC, RAF1, CHUK, JUN, FOS, MAPK6
37	ErbB signaling pathway20	10.9	PIK3CA, BRAF, MYC, RAF1, PAK4, MTOR
38	Activation of PKA through GPCR36	10.9	BRAF, VEGFB, VEGFC, BMP2, BMP6, BMP7
39	Development IGF-RI signaling10	10.9	PIK3CA, MYC, RAF1, BCL2L1, CHUK, MTOR
40	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.9	BCL2, AKT3, ERBB3, CYCS, NTRK1, NGF
41	STAT3 Pathway36	10.7	PIM1, BRAF, MYC, BMP2, BMP6, BMP7
42	Non-small cell lung cancer20	10.7	PIK3CA, RB1, BRAF, RAF1, CDK6, CDKN2A
43	Development VEGF signaling and activation10	10.6	PIK3CA, SELE, VCAM1, RAF1, KDR, CHUK
44	Amoebiasis20	10.6	PIK3CA, SERPINB3, SERPINB4, VCL, LAMA1, LAMC2
45	Transcription Receptor-mediated HIF regulation10	10.5	RAF1, MAPK3, MAPK1, IGFBP3, IGF1, AKT2
46	Measles20	10.5	PIK3CA, CHUK, MSN, CDK6, CD28, CDK2
47	Apoptosis20	10.3	PIK3CA, BIRC2, BCL2, BCL2L1, CHUK, BAX
48	Toxoplasmosis20	10.3	PIK3CA, BIRC2, BCL2, BCL2L1, CHUK, LAMA1
49	Cytokine-cytokine receptor interaction20	10.0	VEGFA, VEGFB, VEGFC, BMP2, BMP7, KDR
50	14-3-3 Induced Apoptosis36	10.0	BCL2, CHUK, JUN, FOS, FOXO3, IL1A

Compounds related to oral squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 427)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	27.6	PIK3C2A, PIN1, PIM1, RECK, VTN, SFN
2	paraffin32	19.3	PCNA, RB1, SERPINB5, VIM, BRAF, VEGFA
3	atp32	18.7	PIK3CA, PIK3C2A, PIM1, RECK, VTN, RB1
4	glucose32	16.0	SETD2, SERPINF1, BRAF, VHL, VEGFC, VCAN
5	glyceraldehyde 3-phosphate32	15.1	SETD2, VEGFC, RARS, BIRC5, LGALS1, S100A6
6	proline32	15.0	PIN1, PIM1, SETD2, VIM, BSG, VHL
7	thymidine32 18	15.9	PIK3CA, PCNA, RB1, VEGFC, VDR, MYC
8	pd 98,05932	13.5	PIK3CA, RECK, VTN, RB1, SETD2, SERPINE1
9	methionine32	13.4	RECK, SERPINF1, VIM, VCL, LGALS1, MTAP
10	hydrogen32 18	14.3	PIN1, PIM1, RARA, RAC1, CKS1B, CHKB
11	cholesterol32 9 18 9	15.9	PIK3CA, PIK3C2A, RECK, VTN, RB1, SELE
12	phosphotyrosine32	12.9	PIK3CA, RECK, RAF1, RAC1, KDR, LGALS1
13	ethanol32 34 9 18 9	16.8	BMP7, RARB, BLVRB, CHKA, MUC1, CDK1
14	gold32	12.6	PIK3C2A, RECK, BRAF, VCL, BMP7, CHUK
15	arsenite32 18	13.6	PIK3CA, PCNA, SETD2, VEGFA, VDR, MYC
16	aspartate32	12.4	PIK3C2A, PIN1, VTN, PCNA, VIM, BRAF
17	polysaccharide32	12.3	RECK, VTN, SELE, SERPINE2, SERPINF2, VCAM1
18	ionomycin32	12.3	PIM1, SETD2, BCL10, CHUK, CDK6, CD274
19	ascorbic acid32 18	13.2	PCNA, SETD2, VDR, BMP2, BMP7, RAF1
20	tamoxifen32 34 9 9	15.2	PIK3CA, VTN, PCNA, SELE, SERPINB5, VIM
21	camptothecin32 42 9 9	15.1	PCNA, RB1, SETD2, MYC, BIRC5, PARP1
22	tetrapeptide32	12.0	PIN1, VTN, RB1, BIRC5, BCL2L1, XIAP
23	arachidonic acid32 9 18 9	14.8	PIK3CA, RECK, VIM, RAC1, BCL2L1, MTOR
24	procollagen32	11.7	PCNA, VIM, BMP2, BMP6, LGALS1, P4HB
25	sulindac32 9 9	13.5	PCNA, BIRC5, BCL2, BCL2L1, BAX, XIAP
26	cytochalasin d32 42	12.5	VTN, SELE, VIM, VCAM1, VCL, RAF1
27	adpribose32	11.5	PIK3CA, PCNA, RB1, BIRC5, PARP1, BCL2L1
28	progestin32	11.4	VIM, VEGFA, KDR, S100A6, CDK6, CDK4
29	sodium dodecylsulfate32	11.3	VTN, SERPINF2, SERPINE1, MYC, BMP6, RAF1
30	silymarin32	11.3	PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
31	carbon32	11.2	VTN, PCNA, VDR, BLVRB, MTHFR, ITGA2
32	indole-3-carbinol32	11.2	BIRC5, PARP1, BCL2, BCL2L1, BAX, XIAP
33	folate32	11.1	RECK, SELE, VIM, VHL, VDR, VCAM1
34	sodium nitroprusside32	11.0	PIK3C2A, PCNA, BMP6, BLVRB, APP, FASLG
35	vitamin d32	11.0	SERPINE1, VIM, VDR, BMP2, BMP6, BMP7
36	mg 13232 42	11.8	PCNA, VDR, MYC, RARA, BIRC5, PARP1
37	carbachol32 9 9	12.8	MAPK10, CTSB, ADRB2
38	rotenone32	10.7	PARP1, BCL2, BCL2L1, GSR, IL1A, ANGPT1
39	alginate32	10.6	VCAN, BMP2, BMP7, CD36, CD44, MMP13
40	isoproterenol32 9 9	12.5	VIM, BRAF, RAF1, AR, FGF2, IL1A
41	bortezomib32 9 9	12.5	SETD2, VEGFA, MYC, BIRC5, PARP1, KDR
42	dihydrotestosterone32 9 18 9	13.4	SETD2, SERPINE1, VIM, VDR, BMP2, BMP6
43	cetuximab32 34 9 9	13.4	BRAF, KDR, CDKN1B, AREG, ERBB3, ERBB4
44	topotecan32 9 9	12.2	SETD2, BIRC5, PARP1, BCL2, BCL2L1, MGMT
45	ibmx32	9.9	VCAM1, BMP2, RARB, RAF1, CDK2, MMP2
46	losartan32 34 9 9	12.8	PCNA, SELE, SERPINE1, VCAM1, BMP6, CD36
47	thyroxine32 18	10.6	PIK3C2A, PCNA, SERPINF2, VDR, CHKA, CHKB
48	tpck32	9.3	PARP1, BCL2L1, BAK1, JUN, IL1B, IL6
49	ndga32	9.1	VCAM1, JUN, MMP13, MMP3, FOS, IL1B
50	gm-csf32	8.5	VEGFA, BMP6, BCL2L1, IL10, IL1A, IL1B

Cellular components related to oral squamous cell carcinoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	24.7	PIDD, PIK3C2A, PIN1, PIM1, PDCD4, SFN
2	nucleus	GO:005634	24.5	ZNF510, PIDD, PIK3C2A, PIN1, PIM1, PDCD4
3	cytosol	GO:005829	19.1	PIK3CA, PIK3C2A, PDCD4, SFRP1, BUB1B, SERPINE2
4	plasma membrane	GO:005886	18.6	PIK3C2A, PIM1, PDCD1, PDCD1LG2, RECK, SFRP1
5	nucleolus	GO:005730	15.3	PDCD4, PCNA, RBL2, SENP5, NANOG, MYC
6	nucleoplasm	GO:005654	15.1	PIN1, PCNA, RB1, RBL2, RBMX, SET
7	extracellular region	GO:005576	15.1	PDCD1LG2, VTN, SERPINE2, SERPINF2, SERPINF1, SERPINE1
8	integral to plasma membrane	GO:005887	13.1	LRP12, CLDN1, KDR, SDC1, MUC1, MTNR1A
9	perinuclear region of cytoplasm	GO:048471	13.0	BUB1B, SELE, SET, LMNA, LIMS1, BCL10
10	cell surface	GO:009986	12.9	SFRP1, VEGFA, VCAM1, BMP2, RARA, LGALS1
11	extracellular space	GO:005615	12.5	VTN, SFN, SFRP1, SFRP2, SFRP5, SELE
12	extracellular matrix	GO:031012	11.7	VTN, SFRP1, SFRP2, SERPINE2, SERPINF1, SERPINE1
13	external side of plasma membrane	GO:009897	11.4	VCAM1, KDR, B2M, CD28, CD36, CD86
14	platelet alpha granule lumen	GO:031093	10.7	SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC, FN1
15	caveola	GO:005901	10.4	SELE, FASLG, MAPK3, MAPK1, F2R, CAV1

Biological processes related to oral squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 88)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	14.6	PIDD, LRP12, PDCD1, SFN, SFRP5, VEGFC
2	cell proliferation	GO:008283	13.9	PIM1, SFN, PCNA, BUB1B, SERPINF1, NANOG
3	mitotic cell cycle	GO:000278	13.7	PCNA, BUB1B, RB1, RBL2, RAD21, BIRC5
4	cell adhesion	GO:007155	13.6	VTN, VCAM1, VCAN, VCL, RAC1, CLDN1
5	apoptotic process	GO:006915	13.2	PIDD, PIM1, PDCD1, PDCD4, SFN, SFRP5
6	negative regulation of transcription, DNA-dependent	GO:045892	12.8	PDCD4, SFRP1, SFRP2, RB1, SET, VDR
7	positive regulation of cell migration	GO:030335	12.6	VEGFA, BMP2, KDR, ITGAV, ITGB1, MMP14
8	response to wounding	GO:009611	12.6	RAC1, ITGB4, FN1, FGF7, MET, MDK
9	positive regulation of transcription, DNA-dependent	GO:045893	12.5	SFRP1, RB1, VHL, MYC, BMP2, BMP7
10	virus-host interaction	GO:019048	12.5	RB1, VIM, VCAM1, CLDN1, KDR, BAX
11	negative regulation of apoptotic process	GO:043066	12.5	PIDD, PIM1, SFRP1, SERPINE1, BRAF, VEGFA
12	G1/S transition of mitotic cell cycle	GO:000082	12.4	PCNA, RB1, BCL2, CKS1B, UBC, CDK6
13	cell migration	GO:016477	12.2	VAV2, PAK4, CEACAM1, JUP, FSCN1, CDH2
14	angiogenesis	GO:001525	12.1	PIK3CA, SETD2, SERPINE1, VEGFA, VEGFC, VAV2
15	blood coagulation	GO:007596	12.1	PIK3CA, SERPINE2, SERPINF2, SERPINE1, BSG, VEGFA
16	positive regulation of cell proliferation	GO:008284	12.1	SFRP1, SFRP2, VEGFA, VEGFC, MYC, RARA
17	innate immune response	GO:045087	12.1	PIN1, BCL10, BCL2, BCL2L1, CHUK, UBC
18	response to drug	GO:042493	11.9	SFRP1, SFRP2, VEGFC, MYC, BCL2, LGALS1
19	negative regulation of cell proliferation	GO:008285	11.8	SFN, SFRP1, SFRP2, SFRP5, SERPINE2, VHL
20	response to organic cyclic compound	GO:014070	11.7	SFRP1, BAK1, MSH2, JUN, CDKN1A, CDK1
21	negative regulation of neuron apoptotic process	GO:043524	11.6	SET, BRAF, VEGFB, BCL2, BCL2L1, BAX
22	response to radiation	GO:009314	11.5	SERPINE2, BCL2, JUN, CDC25A, MMP9, FANCG
23	positive regulation of cell division	GO:051781	11.4	VEGFA, VEGFB, VEGFC, FIGF, FGF1, FGF2
24	insulin receptor signaling pathway	GO:008286	11.4	PIK3CA, PIK3C2A, RAF1, MTOR, ATP6V1C1, CDK1
25	cellular component movement	GO:006928	11.3	SERPINB5, VIM, VCL, RAC1, PAK4, MSN
26	phosphatidylinositol-mediated signaling	GO:048015	11.3	PIK3CA, PIK3C2A, PCNA, BUB1B, CHUK, MTOR
27	response to ethanol	GO:045471	11.2	BCL2, BAK1, S100A8, CDK1, MMP9, MGMT
28	induction of apoptosis by intracellular signals	GO:008629	11.2	MYC, BCL2, BCL2L1, BAK1, BAX, XIAP
29	platelet degranulation	GO:002576	11.2	SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC, VCL
30	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.2	SFRP2, RB1, RBMX, SERPINF2, SERPINE1, NANOG
31	positive regulation of apoptotic process	GO:043065	11.1	SFRP1, SFRP2, BMP2, RARB, BAK1, BAX
32	epidermal growth factor receptor signaling pathway	GO:007173	11.0	PIK3CA, PIK3C2A, RAF1, CHUK, UBC, MTOR
33	protein phosphorylation	GO:006468	11.0	PIM1, BRAF, RARA, RAF1, BIRC5, CHUK
34	inflammatory response	GO:006954	10.9	SELE, BMP2, BMP6, RAC1, CHUK, S100A8
35	fibroblast growth factor receptor signaling pathway	GO:008543	10.9	PIK3CA, BRAF, RAF1, CHUK, UBC, MTOR
36	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.9	SERPINF2, BRAF, VEGFB, BMP2, KDR, S100A7
37	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.9	VHL, VDR, MYC, BMP2, RARB, PARP1
38	response to hypoxia	GO:001666	10.8	VEGFA, VCAM1, BMP2, RAF1, BCL2, XRCC1
39	positive regulation of protein phosphorylation	GO:001934	10.7	PIN1, VEGFA, BMP2, MTOR, AXIN1, FLT4
40	positive regulation of angiogenesis	GO:045766	10.7	SFRP2, SERPINE1, VEGFA, KDR, MMP9, FLT1
41	nerve growth factor receptor signaling pathway	GO:048011	10.6	PIK3CA, BRAF, VAV2, RAF1, RAC1, CHUK
42	heart development	GO:007507	10.5	PCNA, VCAM1, VCAN, BMP2, RAF1, ID1
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.5	VTN, VEGFA, VEGFB, MTOR, CD36, CD80
44	anti-apoptosis	GO:006916	10.4	PIK3CA, BRAF, VHL, VEGFB, BIRC2, BIRC5
45	response to mechanical stimulus	GO:009612	10.3	BMP2, JUN, MMP9, FOSL1, ANGPT2, CCL2
46	platelet activation	GO:030168	10.3	PIK3CA, SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC
47	positive regulation of MAPK cascade	GO:043410	10.3	KDR, CD36, CDH2, ITGB1, FLT1, FLT4
48	aging	GO:007568	10.0	SERPINF1, VDR, VCAM1, BAK1, JUN, IL1B
49	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.9	PIK3CA, SFRP2, BRAF, VEGFA, RAF1, BCL2
50	MAPK cascade	GO:000165	9.4	MYC, RAF1, CDK1, FGFR1, FGFR3, IL1B

Molecular functions related to oral squamous cell carcinoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	29.8	TLR2, SYK, STAT3, STAT5A, PSMD9, DBC1
2	protein homodimerization activity	GO:042803	13.3	SERPINF2, VEGFA, VEGFB, BMP2, BIRC5, BCL2
3	ATP binding	GO:005524	13.2	BRAF, RARS, RAF1, PAK4, KDR, CKM
4	protein kinase binding	GO:019901	12.4	MAPK6, ADAM10, PGAM1, NPM1, MAP2K3, CCNE1
5	protein heterodimerization activity	GO:046982	12.2	TOP2A, AHR, EGFR, HIF1A, TLR2, TGFB1
6	identical protein binding	GO:042802	12.0	COL1A1, SMURF2, NFKBIA, SKP2, EGFR, THBS1
7	transcription factor binding	GO:008134	11.5	HOXA7, ETS1, AR, MLXIPL, CDKN2A, JUN
8	receptor binding	GO:005102	11.3	MSN, LAMA1, LGI1, BMP2, SERPINE1, RARA
9	enzyme binding	GO:019899	11.2	VHL, RARA, RAC1, BIRC5, BIRC7, BCL10
10	integrin binding	GO:005178	11.0	ADAM10, CD9, ADAM17, SYK, THBS1, ITGB1
11	growth factor activity	GO:008083	10.8	VEGFA, VEGFB, VEGFC, BMP2, BMP6, BMP7
12	transcription regulatory region DNA binding	GO:044212	10.7	TFAP2A, TP63, TP53, YAP1, ERBB4, AR