MCID: ORL015
MIFTS: 40

Oral Squamous Cell Carcinoma malady

Oral, Cancer categories

Summaries for Oral Squamous Cell Carcinoma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Oral Squamous Cell Carcinoma is related to squamous cell carcinoma and oral cancer. An important gene associated with Oral Squamous Cell Carcinoma is HRAS (Harvey rat sarcoma viral oncogene homolog), and among its related pathways is MicroRNAs in cancer. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node.

Aliases & Classifications for Oral Squamous Cell Carcinoma

Sources:
43NIH Rare Diseases
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Oral


Aliases & Descriptions:

oral squamous cell carcinoma 43


Related Diseases for Oral Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.7PDPN, DEFB4A, VEGFC, MAGEA1, HRAS, NME1
2oral cancer31.4KRT19, HRAS, VEGFC
3leukoplakia31.4NME1, DEFB4A
4lichen planus31.1DEFB4A
5oral candidiasis30.5DEFB4A
6adenocarcinoma30.3PDPN, VEGFC, MAGEA1, HRAS, NME1, KRT19
7anal squamous cell carcinoma11.1
8oral leukoplakia11.0
9squamous cell papilloma10.9
10hypoxia10.8
11oral lichen planus10.8
12bone carcinoma10.7
13verrucous carcinoma10.7
14oral submucous fibrosis10.6
15small cell carcinoma10.5
16parathyroid carcinoma10.4
17colon squamous cell carcinoma10.4
18adenoma10.4
19basal cell carcinoma10.4
20esophageal squamous cell carcinoma10.4
21fanconi's anemia10.3
22thrombocytosis10.3
23adenoid squamous cell carcinoma10.3
24oral mucosa leukoplakia10.3
25trichinosis10.3
26hypercalcemia10.3
27adenoid cystic carcinoma10.3
28large cell carcinoma10.3
29fibromatosis10.3
30juvenile hyaline fibromatosis10.3
31crohn's disease10.2
32cardiac tamponade10.2
33bullous pemphigoid10.2
34carotid stenosis10.2
35dyskeratosis congenita10.2
36keratosis follicularis10.2
37anal margin squamous cell carcinoma10.2
38microcephaly10.2
39paracoccidioidomycosis10.2
40extramedullary plasmacytoma10.2
41verrucous papilloma10.2
42acanthoma10.2
43anal margin carcinoma10.2
44skin squamous cell carcinoma10.2
45stomatitis10.2
46vascular disease10.2
47wilms tumor10.2
48actinic cheilitis10.2
49chromosome 3q deletion10.2
50whim syndrome10.2

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to oral squamous cell carcinoma

Clinical Features for Oral Squamous Cell Carcinoma

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Oral Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Oral Squamous Cell Carcinoma

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Search CenterWatch for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

33
Bone marrow, Whole blood, Lymph node, Spleen, Smooth muscle, Colon, Lung, Skin, Placenta, Prostate, Tonsil, Nk cells, T cells, B cells, Endothelial, Hypothalamus, Tongue

Animal Models for Oral Squamous Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Oral Squamous Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Oral Squamous Cell Carcinoma:

(show top 50)    (show all 1944)
idTitleAuthorsYear
1
Expression of matriptase correlates with tumor progression and clinical prognosis in oral squamous cell carcinoma. (24382204)
2014
2
Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease. (23265705)
2013
3
Evaluating the performance of fibronectin 1 (FN1), integrin I+4I^1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC). (23116545)
2013
4
Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma. (23500413)
2013
5
Cervical lymph node metastasis in oral squamous cell carcinoma: A correlative study between histopathological malignancy grading and lymph node metastasis. (24355962)
2013
6
Simultaneous quantification of nucleoproteins and comparison of methyl green-pyronin Y and Feulgen staining in sections of oral squamous cell carcinoma, dysplastic lesions and normal mucosa. (24219353)
2013
7
Loss of ELF3 immunoexpression is useful for detecting oral squamous cell carcinoma but not for distinguishing between grades of epithelial dysplasia. (23643910)
2013
8
Efficacy of crystallization test for screening of oral squamous cell carcinoma with clinico-pathological correlation. (24047839)
2013
9
The clinical predictive factors for subsequent distant metastasis in patients with locoregionally advanced oral squamous cell carcinoma. (23142556)
2013
10
Factors influencing relative speech intelligibility in patients with oral squamous cell carcinoma: a prospective study using automatic, computer-based speech analysis. (23845298)
2013
11
Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis. (22740306)
2013
12
Cucurbitacin E as inducer of cell death and apoptosis in human oral squamous cell carcinoma cell line SAS. (23965977)
2013
13
Comparative proteomic analysis of oral squamous cell carcinoma and adjacent non-tumour tissue from Thailand. (24112734)
2013
14
Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. (21925926)
2012
15
Human papilloma virus, herpes simplex virus and epstein barr virus in oral squamous cell carcinoma from eight different countries. (22287747)
2012
16
Increased I9Np63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. (21833468)
2011
17
Primary tumor induces sentinel lymph node lymphangiogenesis in oral squamous cell carcinoma. (20308006)
2010
18
Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems. (19963131)
2010
19
Potential therapeutic strategy for oral squamous cell carcinoma by ErbB3-binding protein 1 gene transfer. (19937055)
2010
20
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. (20975919)
2009
21
Fine deletion analysis of 1p36 chromosomal region in oral squamous cell carcinomas. (18363675)
2009
22
Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas. (19293805)
2009
23
Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma. (19272813)
2009
24
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma. (19497117)
2009
25
Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. (19176372)
2009
26
Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. (19239949)
2009
27
Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma. (19522851)
2009
28
Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study. (19336864)
2009
29
A high concentration of MMP-2/gelatinase A and MMP-9/gelatinase B reduce NK cell-mediated cytotoxicity against an oral squamous cell carcinoma cell line. (18853752)
2008
30
Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma. (18813829)
2008
31
Upregulation of heme oxygenase-1 expression in areca-quid-chewing-associated oral squamous cell carcinoma. (18492619)
2008
32
Strong association of interleukin-4 (-590 C/T) polymorphism with increased risk for oral squamous cell carcinoma in Europeans. (17428692)
2007
33
Selection and quantitative detection of target genes in oral squamous cell carcinoma]. (17074177)
2006
34
Transcription promoter activity of the human S100A7 gene in oral squamous cell carcinoma cell lines. (16675044)
2006
35
P-cadherin expression and survival rate in oral squamous cell carcinoma: an immunohistochemical study. (15967043)
2005
36
Survivin expression is significantly higher in pN+ oral and oropharyngeal primary squamous cell carcinomas than in pN0 carcinomas. (16353406)
2005
37
Evaluation of secretory mucin concentration of patients with squamous cell carcinoma oral cavity. (16358996)
2005
38
The role of Bak expression in apoptosis of the oral squamous cell carcinoma (OSCC) and metastases to lymph nodes (LNMs). (15638360)
2004
39
Detection of circulating cancer cells in human oral squamous cell carcinoma. (12888894)
2003
40
Prognostic value of Bak expression in oral tongue squamous cell carcinomas. (12579274)
2003
41
Characterization of novel cell lines established from three human oral squamous cell carcinomas. (12011992)
2002
42
Expression and clinical significance of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinomas]. (12508547)
2002
43
Thymidine phosphorylase expression in oral squamous cell carcinoma. (12167436)
2002
44
MET receptor is overexpressed but not mutated in oral squamous cell carcinomas. (11748586)
2001
45
Alterations of p53, pRb, cyclin D(1) and cdk4 in human oral and pharyngeal squamous cell carcinomas. (10899671)
2000
46
Localization of Fas antigen in oral squamous cell carcinoma. (10203220)
1999
47
Overexpression of cyclin-D1, bcl-2, and bax proteins, proliferating cell nuclear antigen (PCNA), and DNA-ploidy in squamous cell carcinoma of the oral cavity. (9824094)
1998
48
Changes in the expression of alpha v integrins in oral squamous cell carcinomas. (9049904)
1997
49
Oral squamous cell carcinoma in a case of dyskeratosis congenita. (8060104)
1994
50
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma. (1459726)
1992

Genetic Variations for Oral Squamous Cell Carcinoma

Expression for genes affiliated with Oral Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for genes affiliated with Oral Squamous Cell Carcinoma

Sources:
30KEGG
See all sources

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2SERPINB5, HRAS, MIR124-2, MIR124-1, MIR124-3

Compounds for genes affiliated with Oral Squamous Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Oral Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4511.9SERPINB5, PDPN, DEFB4A, VEGFC, MAGEA1, HRAS
2progesterone45 60 29 11 2415.7DEFB103B, DEFB4A, VEGFC, HRAS, NME1, KRT19
3steroid4511.5DEFB103B, DEFB4A, HRAS, NME1, KRT19, SERPINB5
4vegf4511.5PDPN, VEGFC, HRAS, NME1, KRT19, SERPINB5
5estrogen4511.3DEFB4A, VEGFC, HRAS, NME1, KRT19, SERPINB5
6p0024511.3DEFB4A, NME1, KRT19, SERPINB5
7glyceraldehyde 3-phosphate4511.2KRT19, NME1, VEGFC, DEFB4A
8matrigel4511.1VEGFC, NME1, KRT19, SERPINB5
9estradiol45 11 2412.6VEGFC
10hbd24510.5DEFB4A, DEFB103B

GO Terms for genes affiliated with Oral Squamous Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:05067910.9NME1, HRAS, VEGFC

Products for genes affiliated with Oral Squamous Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet