MCID: ORL015
MIFTS: 59

Oral Squamous Cell Carcinoma

Categories: Rare diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Oral Squamous Cell Carcinoma

MalaCards integrated aliases for Oral Squamous Cell Carcinoma:

Name: Oral Squamous Cell Carcinoma 12 72 49 14
Squamous Cell Carcinoma of Mouth 69
Mouth Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050866
UMLS 69 C0585362

Summaries for Oral Squamous Cell Carcinoma

Disease Ontology : 12 An oral cavity cancer that has material basis in squamous cells.

MalaCards based summary : Oral Squamous Cell Carcinoma, also known as squamous cell carcinoma of mouth, is related to squamous cell carcinoma and papilloma. An important gene associated with Oral Squamous Cell Carcinoma is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and skin, and related phenotypes are Decreased cell migration and Decreased viability

Wikipedia : 72 Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer... more...

Related Diseases for Oral Squamous Cell Carcinoma

Diseases related to Oral Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.7 CCND1 CDH1 CDKN1B CDKN2A EGFR HRAS
2 papilloma 31.2 CCND1 CDKN1B CDKN2A TP53
3 melanoma 30.6 CCND1 CDH1 CDKN2A CTNNB1 HRAS TP53
4 retinoblastoma 30.2 CCND1 CDKN1B CDKN2A TP53
5 colorectal adenocarcinoma 30.2 CDH1 CTNNB1 EGFR HRAS TP53 VEGFA
6 oral cancer 30.0 CASP3 CCND1 CDH1 CDKN2A EGFR KRT19
7 pancreas adenocarcinoma 29.7 AKT1 CDH1 CDKN2A CTNNB1 EGFR HRAS
8 tongue cancer 29.6 CCND1 CDH1 CDKN2A CTNNB1 FAM168A MMP2
9 adenocarcinoma 29.6 AKT1 CCND1 CDH1 CDKN2A CTNNB1 EGFR
10 squamous cell carcinoma, head and neck 29.2 CASP3 CCND1 CDH1 CDKN2A EGFR HRAS
11 esophageal cancer 28.8 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
12 spitz nevus 10.7 CDKN2A HRAS TP53
13 nasal cavity adenocarcinoma 10.7 CDKN2A HRAS TP53
14 orbital lymphangioma 10.7 EGFR PDPN
15 brain stem astrocytic neoplasm 10.7 CDKN2A TP53
16 meningeal melanomatosis 10.7 CDKN2A HRAS TP53
17 mucinous cystadenocarcinoma of the pancreas 10.7 PDPN VEGFC
18 brain ependymoma 10.7 EGFR TP53
19 squamous cell carcinoma of the larynx 10.7 CDKN2A EGFR TP53
20 ethmoid sinus cancer 10.7 CCND1 EGFR HRAS
21 soft tissue sarcoma 10.7 EGFR TP53 VEGFA
22 ethmoid sinus adenocarcinoma 10.7 CCND1 EGFR HRAS
23 balanitis xerotica obliterans 10.7 CCND1 CDKN2A TP53
24 breast papillomatosis 10.7 CCND1 CDKN2A
25 biliary tract neoplasm 10.7 CDKN2A HRAS TP53
26 oropharynx cancer 10.6 CDKN2A EGFR TP53
27 primary peritoneal carcinoma 10.6 EGFR TP53 VEGFA
28 breast metaplastic carcinoma 10.6 CDH1 EGFR TP53
29 leukoplakia 10.6
30 basaloid squamous cell carcinoma 10.6 CDKN2A EGFR TP53
31 infiltrating angiolipoma 10.6 CDKN2A VEGFA VEGFC
32 hidradenocarcinoma 10.6 CCND1 EGFR TP53
33 salivary gland adenoid cystic carcinoma 10.6 CCND1 CDH1 HRAS
34 pancreatic ductal carcinoma 10.6 CDKN2A TP53 VEGFA
35 villous adenocarcinoma 10.6 EGFR MMP2 MMP9
36 adenomyosis 10.6 MMP2 MMP9 VEGFA
37 lung benign neoplasm 10.6 EGFR HRAS TP53
38 extracranial arteriovenous malformation 10.6 MMP2 MMP9
39 biliary papillomatosis 10.6 HRAS KRT19 TP53
40 vulva cancer 10.6 CDKN2A EGFR TP53
41 odontogenic myxoma 10.6 MMP2 MMP9 VEGFA
42 bladder carcinoma in situ 10.6 CDKN2A KRT19 TP53
43 lung giant cell carcinoma 10.6 CDH1 MMP2 MMP9
44 mucinous adenocarcinoma 10.6 CDKN2A EGFR TP53
45 lymphangiosarcoma 10.6 PDPN VEGFA VEGFC
46 cholecystitis 10.6 CDH1 CDKN2A TP53
47 nasal cavity squamous cell carcinoma 10.6 CDKN2A MMP2 MMP9
48 retinal cancer 10.6 CCND1 CDKN1B CDKN2A TP53
49 in situ carcinoma 10.6 CDH1 CDKN2A EGFR TP53
50 liver angiosarcoma 10.6 HRAS KRT19 TP53

Graphical network of the top 20 diseases related to Oral Squamous Cell Carcinoma:



Diseases related to Oral Squamous Cell Carcinoma

Symptoms & Phenotypes for Oral Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.55 AKT1 CTNNB1 EGFR HRAS VEGFC
2 Decreased viability GR00055-A-2 9.55 EGFR HRAS
3 Decreased viability GR00221-A-1 9.55 CDKN1B CDKN2A EGFR HRAS AKT1 CDH1
4 Decreased viability GR00221-A-2 9.55 HRAS AKT1
5 Decreased viability GR00221-A-3 9.55 CDKN2A HRAS AKT1
6 Decreased viability GR00221-A-4 9.55 CDKN2A EGFR AKT1
7 Decreased viability GR00301-A 9.55 CDH1
8 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 CTNNB1 EGFR HRAS VEGFA VEGFC

MGI Mouse Phenotypes related to Oral Squamous Cell Carcinoma:

43 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.54 CTNNB1 EGFR HOPX HRAS KRT19 MMP2
2 homeostasis/metabolism MP:0005376 10.45 MMP9 PDPN TP53 VEGFA VEGFC AKT1
3 growth/size/body region MP:0005378 10.44 MMP9 PDPN TP53 VEGFA AKT1 CASP3
4 mortality/aging MP:0010768 10.44 VEGFA VEGFC AKT1 CASP3 CCND1 CDH1
5 cellular MP:0005384 10.42 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
6 digestive/alimentary MP:0005381 10.4 CASP3 CCND1 CDH1 CDKN1B CDKN2A CTNNB1
7 immune system MP:0005387 10.38 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
8 integument MP:0010771 10.37 CDH1 CDKN1B CDKN2A CTNNB1 EGFR HRAS
9 behavior/neurological MP:0005386 10.36 AKT1 CASP3 CCND1 CDKN1B CDKN2A CTNNB1
10 endocrine/exocrine gland MP:0005379 10.35 TP53 VEGFA AKT1 CASP3 CCND1 CDH1
11 hematopoietic system MP:0005397 10.34 AKT1 CASP3 CCND1 CDKN1B CDKN2A CTNNB1
12 neoplasm MP:0002006 10.29 AKT1 CCND1 CDH1 CDKN1B CDKN2A CTNNB1
13 muscle MP:0005369 10.27 CDKN2A CTNNB1 EGFR HOPX MMP2 MMP9
14 nervous system MP:0003631 10.27 KRT19 MMP2 MMP9 AKT1 CASP3 CCND1
15 craniofacial MP:0005382 10.25 CASP3 CCND1 CDKN1B CTNNB1 EGFR HRAS
16 embryo MP:0005380 10.24 HOPX KRT19 TP53 VEGFA CDKN2A CTNNB1
17 no phenotypic analysis MP:0003012 10.17 CASP3 CDH1 CDKN1B CDKN2A CTNNB1 EGFR
18 normal MP:0002873 10.1 AKT1 CCND1 CDH1 CTNNB1 EGFR HRAS
19 reproductive system MP:0005389 10.03 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
20 respiratory system MP:0005388 10 CDKN2A CTNNB1 EGFR HOPX HRAS MMP2
21 renal/urinary system MP:0005367 9.92 CASP3 CDKN1B CTNNB1 EGFR HRAS MMP9
22 pigmentation MP:0001186 9.85 CASP3 CDKN1B CDKN2A CTNNB1 EGFR TP53
23 skeleton MP:0005390 9.8 AKT1 CASP3 CCND1 CDKN1B CDKN2A CTNNB1
24 vision/eye MP:0005391 9.32 CASP3 CCND1 CDKN1B CDKN2A CTNNB1 EGFR

Drugs & Therapeutics for Oral Squamous Cell Carcinoma

Drugs for Oral Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2, Phase 3 15663-27-1 2767 441203 84093
2
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
3
Docetaxel Approved May 1996, Investigational Phase 2, Phase 3 114977-28-5 148124 9877265
4 Immunosuppressive Agents Phase 2, Phase 3
5 Antimetabolites Phase 2, Phase 3
6 Antimetabolites, Antineoplastic Phase 2, Phase 3
7 Antimitotic Agents Phase 2, Phase 3,Early Phase 1
8
Paclitaxel Approved, Vet_approved Phase 2,Early Phase 1 33069-62-4 36314
9
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
10
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
11
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
12 Mitogens Phase 2,Phase 1
13 Albumin-Bound Paclitaxel Phase 2,Early Phase 1
14 Protective Agents Phase 2
15 Antineoplastic Agents, Phytogenic Phase 2,Early Phase 1
16 Antioxidants Phase 2
17
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
18 Analgesics Phase 2
19 Cyclooxygenase 2 Inhibitors Phase 2
20 Cyclooxygenase Inhibitors Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Pharmaceutical Solutions Phase 1, Phase 2
24 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2
27 Protein Kinase Inhibitors Phase 2
28 Antirheumatic Agents Phase 2
29
Ethanol Approved 64-17-5 702
30
Phenol Approved, Experimental Early Phase 1 108-95-2 996
31 Raspberry Approved, Nutraceutical
32 Licorice Approved, Nutraceutical Early Phase 1
33 Lugol's solution
34 Antibodies, Monoclonal
35 Anti-Bacterial Agents Early Phase 1
36 Immunoglobulins
37 Antimalarials Early Phase 1
38 Antibodies
39 Antiviral Agents Early Phase 1

Interventional clinical trials:

(show all 42)

# Name Status NCT ID Phase Drugs
1 Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL Unknown status NCT01039298 Phase 3
2 TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma Completed NCT01542931 Phase 2, Phase 3 TPF induction chemotherapy
3 Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer Recruiting NCT01772706 Phase 3
4 A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma Completed NCT00933387 Phase 2 Cetuximab,Paclitaxel,Cisplatin
5 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
6 Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma Recruiting NCT02739204 Phase 2 Celecoxib
7 A Dye for the Detection of Cancer of the Tongue and Mouth Recruiting NCT03085147 Phase 1, Phase 2 Olaparib
8 Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage Recruiting NCT02290145 Phase 2 TPF group
9 GDF15 Based TPF Induction Chemotherapy for OSCC Patients Recruiting NCT02285530 Phase 2 TPF induction chemotherapy
10 Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study Recruiting NCT02748707 Phase 2 Arm1;Arm 2;Arm 3
11 A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients Active, not recruiting NCT02285543 Phase 2 TPF induction chemotherapy
12 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
13 Gene Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00009841 Phase 1 DC-cholesterol liposome
14 Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma Unknown status NCT01987934
15 The Role of microRNA-29b in the Oral Squamous Cell Carcinoma Unknown status NCT02009852
16 The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma Unknown status NCT01946230
17 The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma Unknown status NCT00173849
18 Neck Surgery in Treating Patients With Early-Stage Oral Cancer Unknown status NCT00571883
19 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166
20 Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity Unknown status NCT01636544
21 The Functional and Clinicopathological Roles and Therapeutic Implication of Connective Tissue Growth Factor in Peritoneal Metastasis of Gastric Cancer Unknown status NCT01627119
22 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361
23 Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions Completed NCT02323672
24 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
25 Epstein-Barr Detection in Oral Cancer Completed NCT01039272
26 Human Papillomavirus on Oral Tissue, Saliva and Serum Completed NCT01043328
27 Autofluorescence for the Screening of Precancerous and Malignant Lesions Completed NCT01167790
28 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia Completed NCT00835341
29 Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma Recruiting NCT01334320
30 A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. Recruiting NCT02743832
31 Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer Recruiting NCT01587573
32 The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw Recruiting NCT03418454
33 Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors Recruiting NCT02975739 Early Phase 1
34 Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer Recruiting NCT00899704
35 Submandibular Gland Preservation in Neck Dissection Active, not recruiting NCT03385720
36 One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma Active, not recruiting NCT02852343
37 Fluorescent Visualization in Early Oral Cancer Active, not recruiting NCT02306967
38 Freeze-Dried Black Raspberries in Treating Patients With Oral Squamous Cell Cancer Undergoing Surgery Active, not recruiting NCT01465776
39 Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma Not yet recruiting NCT03109457
40 Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03292822 Early Phase 1 Paclitaxel
41 Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study Not yet recruiting NCT03345966
42 Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer Withdrawn NCT03053960

Search NIH Clinical Center for Oral Squamous Cell Carcinoma

Genetic Tests for Oral Squamous Cell Carcinoma

Anatomical Context for Oral Squamous Cell Carcinoma

MalaCards organs/tissues related to Oral Squamous Cell Carcinoma:

38
Lymph Node, Endothelial, Skin, Bone, Tongue, T Cells, Testes

Publications for Oral Squamous Cell Carcinoma

Articles related to Oral Squamous Cell Carcinoma:

(show top 50) (show all 2219)
# Title Authors Year
1
Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator. ( 29422466 )
2018
2
Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. ( 29423682 )
2018
3
Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line. ( 29435078 )
2018
4
Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With Histologic Risk Factors: Are We Over-Treating? ( 29438656 )
2018
5
Meta-analysis of the prognostic value of the neutrophil-to-lymphocyte ratio in oral squamous cell carcinoma. ( 29406591 )
2018
6
Serum bilirubin level predicts post-operative overall survival in oral squamous cell carcinoma. ( 29430757 )
2018
7
Mecambridine induces potent cytotoxic effects, autophagic cell death and modulation of the mTOR/PI3K/Akt signaling pathway in HSC-3 oral squamous cell carcinoma cells. ( 29422960 )
2018
8
A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma. ( 29423024 )
2018
9
Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. ( 29436667 )
2018
10
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
11
Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. ( 29433680 )
2018
12
Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. ( 29444110 )
2018
13
Human Papilloma Virus 16/18: Fabricator of Trouble in Oral Squamous Cell Carcinoma. ( 29432879 )
2018
14
Sequential injection of radioactive nanosized colloids followed by indocyanine green for sentinel lymph node detection in oral squamous cell carcinoma: A proof of concept. ( 29429631 )
2018
15
MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. ( 29407635 )
2018
16
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma. ( 29416107 )
2018
17
Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids. ( 29435298 )
2018
18
Comparison of the expression of TGF-I^1, E-cadherin, N-cadherin, TP53, RB1CC1 and HIF-1I+ in oral squamous cell carcinoma and lymph node metastases of humans and mice. ( 29399192 )
2018
19
Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature. ( 29433990 )
2018
20
Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma. ( 28485478 )
2017
21
Shrinkage in oral squamous cell carcinoma: An analysis of tumor and margin measurements in vivo, post-resection, and post-formalin fixation. ( 28917966 )
2017
22
FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study. ( 29072128 )
2017
23
Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression. ( 28466780 )
2017
24
Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment. ( 27922697 )
2017
25
A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma. ( 28043142 )
2017
26
Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3 in Oral Leukoplakia and Oral Squamous Cell Carcinoma with Deleterious Habits using Polymerase Chain Reaction. ( 28904918 )
2017
27
Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma. ( 28631562 )
2017
28
Role of microscopic spread beyond gross disease as an adverse prognostic factor in oral squamous cell carcinoma. ( 28528911 )
2017
29
Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression. ( 28369091 )
2017
30
Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression. ( 28093311 )
2017
31
A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes. ( 28639054 )
2017
32
High expression of stathmin 1 is a strong prognostic marker in oral squamous cell carcinoma patients treated by docetaxel-containing regimens. ( 26590596 )
2017
33
Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis. ( 28926115 )
2017
34
Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma. ( 28751006 )
2017
35
Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. ( 28426731 )
2017
36
MicroRNA-375 Inhibits Growth and Enhances Radiosensitivity in Oral Squamous Cell Carcinoma by Targeting Insulin Like Growth Factor 1 Receptor. ( 28810236 )
2017
37
CD24+ tumor-initiating cells from oral squamous cell carcinoma induce initial angiogenesis in vivo. ( 28344048 )
2017
38
Complex integrated analysis of lncRNAs-miRNAs-mRNAs in oral squamous cell carcinoma. ( 28939059 )
2017
39
Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9. ( 28267394 )
2017
40
Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma. ( 27923688 )
2017
41
Expression of T-lymphoma invasion and metastasis factor on the occurrence of oral squamous cell carcinoma. ( 28685528 )
2017
42
KLK4 silencing inhibits the growth of oral squamous cell carcinoma through Wnt/I^-catenin signaling pathway. ( 28150891 )
2017
43
PTEN allelic loss is an important mechanism in the late stage of development of oral leukoplakia into oral squamous cell carcinoma. ( 28858374 )
2017
44
Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. ( 27889233 )
2017
45
Long non-coding RNA TUG1 promotes progression of oral squamous cell carcinoma through upregulating FMNL2 by sponging miR-219. ( 28979812 )
2017
46
SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. ( 28237246 )
2017
47
Reciprocal regulation of miR-1254 and c-Myc in oral squamous cell carcinoma suppresses EMT-mediated metastasis and tumor-initiating properties through MAPK signaling. ( 28161631 )
2017
48
Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. ( 27577989 )
2017
49
Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. ( 28938622 )
2017
50
PD-L1 Expression Confers Better Prognosis in Locally Advanced Oral Squamous Cell Carcinoma. ( 28314313 )
2017

Variations for Oral Squamous Cell Carcinoma

Cosmic variations for Oral Squamous Cell Carcinoma:

9 (show top 50) (show all 551)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM3724309 ZNF536 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1935G>C p.Q645H 16
2 COSM11181 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.764T>C p.I255T 16
3 COSM43565 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.857A>G p.E286G 16
4 COSM43695 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.748C>T p.P250S 16
5 COSM10786 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.949C>T p.Q317* 16
6 COSM44894 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.874A>T p.K292* 16
7 COSM43592 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.395A>T p.K132M 16
8 COSM45615 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.776A>G p.D259G 16
9 COSM10659 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.817C>T p.R273C 16
10 COSM11133 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>C p.C242S 16
11 COSM10646 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>A p.C242Y 16
12 COSM10662 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 16
13 COSM10724 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>C p.R280T 16
14 COSM45248 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.805A>T p.S269C 16
15 COSM10727 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.438G>A p.W146* 16
16 COSM43606 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.734G>A p.G245D 16
17 COSM10988 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.772G>A p.E258K 16
18 COSM43635 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.536A>T p.H179L 16
19 COSM44350 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.699C>G p.H233Q 16
20 COSM11063 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.711G>T p.M237I 16
21 COSM11677 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.925C>T p.P309S 16
22 COSM11166 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 16
23 COSM10859 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.814G>T p.V272L 16
24 COSM10958 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>T p.G266V 16
25 COSM10758 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 16
26 COSM44821 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.412G>A p.A138T 16
27 COSM44335 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.958A>T p.K320* 16
28 COSM43708 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 16
29 COSM43947 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 16
30 COSM45636 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.934A>T p.T312S 16
31 COSM11066 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.578A>T p.H193L 16
32 COSM43564 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.708C>A p.Y236* 16
33 COSM10992 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.844C>G p.R282G 16
34 COSM10768 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 16
35 COSM10648 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.524G>A p.R175H 16
36 COSM43714 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.836G>A p.G279E 16
37 COSM10645 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.527G>T p.C176F 16
38 COSM10812 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.722C>T p.S241F 16
39 COSM10660 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.818G>A p.R273H 16
40 COSM45607 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.676G>A p.G226S 16
41 COSM45794 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.421T>G p.C141G 16
42 COSM44233 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.840A>C p.R280S 16
43 COSM10905 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.451C>T p.P151S 16
44 COSM10738 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.542G>A p.R181H 16
45 COSM10739 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.481G>A p.A161T 16
46 COSM44220 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.417G>T p.K139N 16
47 COSM45077 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.390C>T p.L130L 16
48 COSM10654 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.637C>T p.R213* 16
49 COSM44218 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.536A>C p.H179P 16
50 COSM10672 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.577C>T p.H193Y 16

Copy number variations for Oral Squamous Cell Carcinoma from CNVD:

7 (show top 50) (show all 164)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41848 10 24600000 38000000 Deletion Oral squamous cell carcinoma
2 49706 11 110400000 121200000 Deletion Oral squamous cell carcinoma
3 50988 11 121200000 130800000 Deletion Oral squamous cell carcinoma
4 51497 11 12700000 16200000 Deletion Oral squamous cell carcinoma
5 57445 11 63400000 77100000 Amplification CCND1 Oral squamous cell carcinoma
6 57446 11 63400000 77100000 Amplification EMS1 Oral squamous cell carcinoma
7 57448 11 63400000 77100000 Amplification FGF3 Oral squamous cell carcinoma
8 57449 11 63400000 77100000 Amplification FGF4 Oral squamous cell carcinoma
9 57450 11 63400000 77100000 Amplification PPP1CA Oral squamous cell carcinoma
10 57451 11 63400000 77100000 Amplification TAOS1 Oral squamous cell carcinoma
11 58782 11 69471367 69490165 Amplification ORAOV1 Oral squamous cell carcinoma
12 74065 13 1 4500000 Deletion Oral squamous cell carcinoma
13 74179 13 101700000 110300000 Deletion Oral squamous cell carcinoma
14 75170 13 17900000 115169878 Noncopy numberrandom LOH Oral squamous cell carcinoma
15 76133 13 27800000 55300000 Deletion Oral squamous cell carcinoma
16 76134 13 27800000 87700000 Deletion Oral squamous cell carcinoma
17 76220 13 28900000 40100000 Deletion Oral squamous cell carcinoma
18 76534 13 32200000 40100000 Deletion Oral squamous cell carcinoma
19 76709 13 35500000 40100000 Deletion Oral squamous cell carcinoma
20 77109 13 40100000 59600000 Deletion Oral squamous cell carcinoma
21 78640 13 55300000 73300000 Deletion Oral squamous cell carcinoma
22 79281 13 68600000 87700000 Deletion Oral squamous cell carcinoma
23 79539 13 73300000 79000000 Deletion Oral squamous cell carcinoma
24 79879 13 79000000 87700000 Deletion Oral squamous cell carcinoma
25 80342 13 90000000 98200000 Deletion Oral squamous cell carcinoma
26 80629 13 95000000 110300000 Deletion Oral squamous cell carcinoma
27 80632 13 95000000 115169878 Deletion Oral squamous cell carcinoma
28 80634 13 95000000 98200000 Deletion Oral squamous cell carcinoma
29 83034 14 19100000 33300000 Deletion Oral squamous cell carcinoma
30 84231 14 24600000 33300000 Deletion Oral squamous cell carcinoma
31 85052 14 37800000 50900000 Deletion Oral squamous cell carcinoma
32 86340 14 58100000 67900000 Deletion Oral squamous cell carcinoma
33 86341 14 58100000 73800000 Deletion Oral squamous cell carcinoma
34 87452 14 73800000 79300000 Deletion Oral squamous cell carcinoma
35 89133 15 1 19000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
36 90246 15 20700000 40100000 Deletion Oral squamous cell carcinoma
37 91779 15 33600000 40100000 Deletion Oral squamous cell carcinoma
38 91783 15 33600000 44800000 Deletion Oral squamous cell carcinoma
39 92363 15 40100000 49500000 Deletion Oral squamous cell carcinoma
40 92861 15 44800000 49500000 Deletion Oral squamous cell carcinoma
41 93371 15 52900000 72700000 Deletion Oral squamous cell carcinoma
42 95627 15 78300000 89100000 Deletion Oral squamous cell carcinoma
43 95629 15 78300000 98500000 Deletion Oral squamous cell carcinoma
44 106754 17 1 16000000 Deletion Oral squamous cell carcinoma
45 106831 17 1 24000000 Noncopy numberrandom LOH Oral squamous cell carcinoma
46 106907 17 1 81195210 Deletion Oral squamous cell carcinoma
47 106970 17 10700000 50200000 Deletion Oral squamous cell carcinoma
48 109058 17 24000000 81195210 Noncopy numberrandom LOH Oral squamous cell carcinoma
49 112186 17 38100000 57600000 Deletion Oral squamous cell carcinoma
50 114590 17 50200000 70900000 Deletion Oral squamous cell carcinoma

Expression for Oral Squamous Cell Carcinoma

Search GEO for disease gene expression data for Oral Squamous Cell Carcinoma.

Pathways for Oral Squamous Cell Carcinoma

Pathways related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.16 AKT1 CASP3 CCND1 CDH1 CDKN1B CTNNB1
2
Show member pathways
13.94 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
3
Show member pathways
13.85 AKT1 CCND1 CDKN1B CDKN2A EGFR HRAS
4
Show member pathways
13.61 AKT1 CTNNB1 EGFR HRAS KRT19 MMP2
5
Show member pathways
13.53 AKT1 CASP3 CCND1 CDKN1B EGFR HRAS
6
Show member pathways
13.49 AKT1 CASP3 CCND1 EGFR HRAS MMP2
7
Show member pathways
13.46 AKT1 CASP3 EGFR HRAS MMP2 MMP9
8
Show member pathways
13.41 AKT1 CASP3 CDH1 CTNNB1 EGFR HRAS
9
Show member pathways
13.4 AKT1 CASP3 CDH1 CTNNB1 EGFR HRAS
10
Show member pathways
13.17 AKT1 CDKN2A CTNNB1 EGFR HRAS MMP9
11
Show member pathways
13.13 AKT1 CASP3 CDH1 CTNNB1 HRAS TP53
12
Show member pathways
13.09 AKT1 CASP3 CCND1 CDKN1B CTNNB1 EGFR
13
Show member pathways
13.09 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
14
Show member pathways
13.03 AKT1 CCND1 CDKN1B CTNNB1 EGFR HRAS
15
Show member pathways
13.01 AKT1 CASP3 CTNNB1 HRAS MMP9 TP53
16
Show member pathways
12.9 AKT1 CCND1 CDH1 CDKN1B CDKN2A CTNNB1
17
Show member pathways
12.89 AKT1 CASP3 CCND1 CDKN1B TP53
18 12.89 AKT1 CASP3 EGFR HRAS TP53 VEGFA
19
Show member pathways
12.87 AKT1 CDH1 CTNNB1 EGFR HRAS VEGFA
20
Show member pathways
12.85 AKT1 CASP3 CDH1 CTNNB1 HRAS TP53
21
Show member pathways
12.83 AKT1 CDKN1B EGFR HRAS TP53
22
Show member pathways
12.8 AKT1 CASP3 CCND1 CTNNB1 EGFR HRAS
23
Show member pathways
12.78 AKT1 CASP3 EGFR HRAS TP53
24
Show member pathways
12.77 AKT1 CTNNB1 MMP2 MMP9 VEGFA
25
Show member pathways
12.73 AKT1 CASP3 HRAS VEGFA VEGFC
26
Show member pathways
12.73 AKT1 CTNNB1 EGFR HRAS MMP2 TP53
27 12.72 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
28
Show member pathways
12.69 AKT1 CCND1 CDKN1B CDKN2A TP53
29
Show member pathways
12.68 AKT1 CASP3 CCND1 CDKN1B CTNNB1 HRAS
30
Show member pathways
12.63 AKT1 CCND1 CDKN1B EGFR HRAS TP53
31
Show member pathways
12.63 AKT1 CASP3 CDH1 CTNNB1 EGFR HRAS
32 12.62 CASP3 CCND1 CDKN1B CDKN2A EGFR HRAS
33
Show member pathways
12.59 AKT1 CASP3 CTNNB1 EGFR HRAS TP53
34
Show member pathways
12.58 AKT1 CCND1 CDKN1B CDKN2A EGFR HRAS
35 12.57 AKT1 CCND1 CDKN2A CTNNB1 HRAS TP53
36 12.56 AKT1 CCND1 CDH1 CTNNB1 TP53
37
Show member pathways
12.56 CCND1 CDKN1B CTNNB1 EGFR HRAS
38
Show member pathways
12.53 CASP3 EGFR HRAS VEGFA VEGFC
39
Show member pathways
12.53 AKT1 CCND1 CDKN1B HRAS TP53
40
Show member pathways
12.51 AKT1 EGFR HRAS VEGFA VEGFC
41
Show member pathways
12.5 CASP3 CCND1 CDKN1B CDKN2A TP53
42 12.5 CCND1 CDH1 CDKN1B CDKN2A TP53
43
Show member pathways
12.47 AKT1 CCND1 EGFR HRAS
44
Show member pathways
12.45 CCND1 CDKN1B CDKN2A TP53
45 12.44 CASP3 CCND1 CDKN1B CDKN2A HRAS TP53
46
Show member pathways
12.43 AKT1 CCND1 CTNNB1 HRAS
47
Show member pathways
12.42 AKT1 CCND1 EGFR HRAS
48
Show member pathways
12.41 AKT1 CASP3 CDKN1B HRAS TP53 VEGFA
49
Show member pathways
12.38 AKT1 EGFR HRAS VEGFA VEGFC
50
Show member pathways
12.37 AKT1 CASP3 CCND1 CDKN1B EGFR HRAS

GO Terms for Oral Squamous Cell Carcinoma

Cellular components related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.53 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A
2 catenin complex GO:0016342 9.16 CDH1 CTNNB1
3 flotillin complex GO:0016600 8.96 CDH1 CTNNB1

Biological processes related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.99 AKT1 CASP3 CDKN2A CTNNB1 MMP9 TP53
2 negative regulation of gene expression GO:0010629 9.98 AKT1 CTNNB1 HRAS VEGFA
3 negative regulation of cell proliferation GO:0008285 9.98 CDKN1B CDKN2A CTNNB1 HRAS PDPN TP53
4 cell cycle arrest GO:0007050 9.92 CDKN1B CDKN2A HRAS TP53
5 positive regulation of cell migration GO:0030335 9.92 EGFR HRAS MMP9 PDPN VEGFA
6 negative regulation of apoptotic process GO:0043066 9.92 AKT1 CASP3 CDKN1B EGFR MMP9 PDPN
7 cell-cell adhesion GO:0098609 9.89 CDH1 CRNN CTNNB1 EGFR
8 response to hypoxia GO:0001666 9.89 CASP3 CDKN1B MMP2 VEGFA VEGFC
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 AKT1 EGFR VEGFA
10 extracellular matrix disassembly GO:0022617 9.87 CDH1 MMP2 MMP9
11 lung development GO:0030324 9.87 CTNNB1 EGFR PDPN VEGFA
12 cellular response to organic cyclic compound GO:0071407 9.86 AKT1 CASP3 CDKN1B
13 response to organic substance GO:0010033 9.86 AKT1 CASP3 CCND1 CDH1
14 positive regulation of cell proliferation GO:0008284 9.86 AKT1 CCND1 CDKN1B CTNNB1 EGFR HRAS
15 Ras protein signal transduction GO:0007265 9.85 CDKN2A HRAS TP53
16 positive regulation of endothelial cell proliferation GO:0001938 9.85 AKT1 VEGFA VEGFC
17 response to organic cyclic compound GO:0014070 9.85 CASP3 CCND1 CDKN1B EGFR TP53
18 positive regulation of MAP kinase activity GO:0043406 9.84 EGFR HRAS VEGFA
19 epidermal growth factor receptor signaling pathway GO:0007173 9.83 AKT1 EGFR HRAS
20 cellular response to growth factor stimulus GO:0071363 9.82 AKT1 CTNNB1 EGFR
21 positive regulation of neuron apoptotic process GO:0043525 9.81 CASP3 CTNNB1 TP53
22 positive regulation of cell cycle GO:0045787 9.79 CCND1 CDKN1B TP53
23 positive regulation of blood vessel endothelial cell migration GO:0043536 9.78 AKT1 VEGFA VEGFC
24 positive regulation of epithelial cell proliferation GO:0050679 9.78 EGFR HRAS VEGFA VEGFC
25 response to amino acid GO:0043200 9.77 CASP3 CDKN1B TP53
26 response to estradiol GO:0032355 9.77 CASP3 CCND1 CDKN1B CTNNB1 EGFR
27 cellular response to cadmium ion GO:0071276 9.76 AKT1 EGFR MMP9
28 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.75 CASP3 CDKN1B CDKN2A
29 response to X-ray GO:0010165 9.72 CASP3 CCND1 TP53
30 positive regulation of neuroblast proliferation GO:0002052 9.71 CTNNB1 VEGFA VEGFC
31 cellular response to reactive oxygen species GO:0034614 9.71 AKT1 EGFR MMP9 TP53
32 response to drug GO:0042493 9.7 CASP3 CCND1 CDH1 CDKN1B CTNNB1 TP53
33 positive regulation of cellular component movement GO:0051272 9.69 PDPN VEGFA
34 mitotic G1 DNA damage checkpoint GO:0031571 9.68 CCND1 TP53
35 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.65 AKT1 EGFR
36 positive regulation of mast cell chemotaxis GO:0060754 9.64 VEGFA VEGFC
37 cellular response to indole-3-methanol GO:0071681 9.63 CDH1 CTNNB1
38 positive regulation of protein phosphorylation GO:0001934 9.43 AKT1 CCND1 EGFR HRAS MMP9 VEGFA
39 response to UV-A GO:0070141 8.8 AKT1 CCND1 EGFR
40 multicellular organism development GO:0007275 10.21 AKT1 EGFR HOPX PDPN TP53 VEGFA
41 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 AKT1 CDKN2A CTNNB1 EGFR HRAS TP53
42 positive regulation of transcription, DNA-templated GO:0045893 10.1 AKT1 CDH1 CDKN2A CTNNB1 EGFR TP53
43 positive regulation of gene expression GO:0010628 10.05 CDKN2A CTNNB1 HRAS TP53 VEGFA
44 cell proliferation GO:0008283 10.04 AKT1 CTNNB1 EGFR HRAS TP53

Molecular functions related to Oral Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.77 AKT1 CCND1 CTNNB1 EGFR TP53
2 protein phosphatase binding GO:0019903 9.46 CDKN1B CTNNB1 EGFR TP53
3 disordered domain specific binding GO:0097718 9.43 CDKN2A CTNNB1 TP53
4 nitric-oxide synthase regulator activity GO:0030235 9.4 AKT1 EGFR
5 protein kinase binding GO:0019901 9.17 AKT1 CCND1 CDKN1B CDKN2A CTNNB1 EGFR
6 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.13 CASP3 CDKN1B CDKN2A
7 protein binding GO:0005515 10.28 AKT1 CASP3 CCND1 CDH1 CDKN1B CDKN2A

Sources for Oral Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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