MCID: ORL004
MIFTS: 46

Oral Submucous Fibrosis malady

Rare diseases, Gastrointestinal diseases, Oral diseases categories

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 59SNOMED-CT, 42NCIt, 29ICD9CM, 28ICD10 via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 10 45 47 12 51 65
Oral Submucosal Fibrosis, Including of Tongue 10 65
Oral Cavity Submucous Fibrosis 10
 
Oral Submucosal Fibrosis 10
Osmf 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
oral submucous fibrosis:
Age of onset: All ages


External Ids:

Disease Ontology10 DOID:5773
NCIt42 C34866
ICD9CM29 528.8
SNOMED-CT59 32883009
Orphanet51 357154
ICD10 via Orphanet28 K13.5
ICD1027 K13.5

Summaries for Oral Submucous Fibrosis

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Wikipedia:68 Oral submucous fibrosis (OSMF) is a chronic, complex potential potent pre-cancerous ( appox 20% may have... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral leukoplakia and laryngitis, and has symptoms including abnormality of the oral cavity, trismus and abnormality of the pharynx. An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include tongue, skin and endothelial, and related mouse phenotypes are integument and endocrine/exocrine gland.

Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1oral leukoplakia30.6CDH1, GSTM1, GSTT1, MMP2, PTGS2
2laryngitis30.3CDH1, GSTT1, MMP2
3cellulitis30.2CDH1, MMP2, PTGS2, TGFB1
4leukoplakia10.8
5oral squamous cell carcinoma10.8
6oral cancer10.7
7burns10.5
8verrucous carcinoma10.5
9pemphigus vulgaris10.4
10pemphigus10.4
11burning mouth syndrome10.4
12gingivitis10.4
13papilloma10.4
14h. pylori infection10.2PTGS2, TIMP1
15muscle hypertrophy10.2
16adenomatous polyposis coli10.2
17lichen planus10.2
18ankylosis10.2
19disseminated intravascular coagulation10.2
20lipodystrophy10.2
21mouth disease10.2
22periodontitis10.2
23oral lichen planus10.2
24endotheliitis10.2
25tinea nigra10.2MMP2, TIMP1
26fibromatosis, gingival, 110.2MMP2, TGFB1
27adult botryoid rhabdomyosarcoma10.2MMP2, TIMP1
28adenosarcoma of the uterus10.2MMP2, PTGS2
292-hydroxyglutaric aciduria10.2MMP2, TIMP1
30hirsutism-skeletal dysplasia-intellectual disability syndrome10.2HMOX1, TGFB1
31neurofibromatosis, type 210.2MMP2, TIMP1
32duodenum adenoma10.2MMP2, TIMP1
33apocrine adenoma10.2MMP2, TIMP1
34pyloric antrum cancer10.1GSTM1, GSTT1
35cerebral arteriosclerosis10.1CST3, MMP2
36nephronophthisis familial adult spastic quadriparesis10.1TGFB1, TIMP1
37chronic ulcer of skin10.1MMP2, TGFB1, TIMP1
38frontal lobe epilepsy10.1GSTM1, GSTT1
39osteochondritis dissecans10.1PTGS2, TGFB1, TIMP1
40ectodermal dysplasia10.1GSTM1, GSTT1
41gemistocytic astrocytoma10.0CST3, MMP2
42levator syndrome10.0GSTM1, GSTT1
43endometriosis of uterus10.0GSTM1, MMP2, PTGS2
44thrombocytopenia due to platelet alloimmunization10.0COL1A1, TGFB1
45ichthyosis with confetti10.0COL1A1, TGFB1
46syndromic x-linked intellectual disability10.0CST3, MMP2, TIMP1
47laryngeal disease10.0GSTM1, GSTT1, MMP2
48mature gastric teratoma10.0GSTM1, GSTT1
49mutiple parosteal osteochondromatous proliferations10.0GSTM1, GSTT1
50subacute leukemia10.0CDH1, MMP2, TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Symptoms:

 51
  • limited opening of the mouth
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oropharyngeal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
leucovorinapprovedPhase 29221492-18-854575
Synonyms:
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-Folinic acid
(6S)-Leucovorin
(S)-Leucovorin
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinic acid
Folinic acid calcium salt
Folinic acid calcium salt USP27
Folinic acid-SF
Fusilev
 
L-Folinic acid
L-leucovorin
Leucal
Leucovorin
Leucovorin Calcium
Leucovorin calcium
Leucovorin folinic acid
Leucovorin sodium
Leukovorin
Levofolene
Levofolinic acid
Levoleucovorin
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
Wellcovorin
2
CisplatinapprovedPhase 2243715663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatin
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinol-aq
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
3TegafurPhase 275
4AstragalusNutraceuticalPhase 243

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF)Active, not recruitingNCT02645656Phase 2
2A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent ChemoradiotherapyTerminatedNCT01720563Phase 2
3Evaluation of Functional Dimensions of Macintosh Laryngoscope Blade During Direct Laryngoscopy in Patients With Normal Mouth OpeningNot yet recruitingNCT02639897

Search NIH Clinical Center for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

33
Tongue, Skin, Endothelial, T cells, Testes, Salivary gland, Liver

Animal Models for Oral Submucous Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2CDH1, COL1A1, LOR, LOX, PTGS2, TGFB1
2MP:00053797.9CDH1, COL1A1, HMOX1, PTGS2, TGFB1, TIMP1
3MP:00053887.9COL1A1, HMOX1, LOX, MMP2, PTGS2, TGFB1
4MP:00053897.6CDH1, COL1A1, HMOX1, PTGS2, TGFB1, TIMP1
5MP:00053697.5COL1A1, CST3, HMOX1, LOX, MMP2, PTGS2
6MP:00053787.5CDH1, COL1A1, HMOX1, LOR, MMP2, PTGS2
7MP:00020067.3CDH1, COL1A1, CST3, MMP2, PTGS2, TGFB1
8MP:00053877.2CDH1, COL1A1, HMOX1, LOR, MMP2, PTGS2
9MP:00053856.7CDH1, COL1A1, CST3, HMOX1, LOX, MMP2
10MP:00053765.2CDH1, COL1A1, CST3, GSTM1, GSTT1, HMOX1

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 440)
idTitleAuthorsYear
1
Efficacy of nasolabial flap in reconstruction of fibrotomy defect in surgical management of oral submucous fibrosis: a prospective study. (26289230)
2015
2
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut. (26248978)
2015
3
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
4
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
5
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
6
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
7
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
8
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
9
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
10
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
11
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
12
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
13
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
14
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
15
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
16
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
17
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
18
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
19
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
20
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
21
Oral submucous fibrosis in a young patient. (20043056)
2009
22
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
23
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
24
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
25
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
26
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
27
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
28
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
29
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
30
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
31
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
32
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
33
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
34
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
35
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
36
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
37
Oral submucous fibrosis in paediatric age group. (23119548)
1999
38
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
39
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
40
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
41
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
42
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
Oral submucous fibrosis. (3864703)
1985
45
HLA-typing in oral submucous fibrosis. (3864289)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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GO Terms for genes affiliated with Oral Submucous Fibrosis

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Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055788.7COL1A1, LOX, MMP2, TGFB1, TIMP1
2extracellular spaceGO:00056157.3COL1A1, CST3, HMOX1, LOX, MMP2, TGFB1
3extracellular regionGO:00055767.1CDH1, COL1A1, CST3, LOX, MMP2, TGFB1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:002240810.3CDH1, TGFB1
2positive regulation of vascular endothelial growth factor productionGO:001057510.2PTGS2, TGFB1
3glutathione derivative biosynthetic processGO:190168710.2GSTM1, GSTT1
4response to vitamin DGO:003328010.2PTGS2, TGFB1
5bone trabecula formationGO:006034610.1COL1A1, MMP2
6positive regulation of epithelial to mesenchymal transitionGO:001071810.1COL1A1, TGFB1
7negative regulation of extracellular matrix disassemblyGO:001071610.0CST3, TGFB1
8intramembranous ossificationGO:000195710.0COL1A1, MMP2
9face morphogenesisGO:00603259.7COL1A1, MMP2, TGFB1
10cell activationGO:00017759.6CST3, TGFB1, TIMP1
11response to organic cyclic compoundGO:00140709.4CST3, PTGS2, TGFB1
12embryo implantationGO:00075669.3CST3, MMP2, PTGS2
13wound healingGO:00420609.1COL1A1, LOX, TGFB1, TIMP1
14response to oxidative stressGO:00069799.0CST3, HMOX1, PTGS2
15positive regulation of cell proliferationGO:00082849.0CST3, PTGS2, TGFB1, TIMP1
16extracellular matrix disassemblyGO:00226178.8CDH1, COL1A1, MMP2, TIMP1
17response to organic substanceGO:00100338.8CDH1, PTGS2, TGFB1, TIMP1
18response to hypoxiaGO:00016668.8CST3, HMOX1, MMP2, TGFB1
19response to estradiolGO:00323558.6COL1A1, CST3, PTGS2, TGFB1
20extracellular matrix organizationGO:00301988.2CDH1, COL1A1, LOX, MMP2, TGFB1, TIMP1
21response to drugGO:00424937.9CDH1, COL1A1, CST3, LOX, PTGS2, TGFB1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00043649.8GSTM1, GSTT1
2enzyme bindingGO:00198998.8GSTM1, HMOX1, PTGS2, TGFB1

Sources for Oral Submucous Fibrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet