OSMF
MCID: ORL004
MIFTS: 57

Oral Submucous Fibrosis (OSMF) malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Oral Submucous Fibrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition... more...

MalaCards: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to squamous cell carcinoma and gingivitis, and has symptoms including limited opening of the mouth, oropharyngeal neoplasm/tumor/carcinoma/cancer and anomaly of the pharynx/pharyngeal anomaly. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Rheumatoid arthritis and Aflatoxin B1 metabolism. The compounds indomethacin and procollagen have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and salivary gland, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

48
oral submucous fibrosis:
Age of onset: Variable


Aliases & Descriptions:

oral submucous fibrosis 8 42 10 44 48 60
oral submucosal fibrosis, including of tongue 8 60
oral cavity submucous fibrosis 8
oral submucosal fibrosis 8
osmf 48


External Ids:

Disease Ontology8 DOID:5773
ICD9CM27 528.8
NCIt39 C34866
SNOMED-CT56 32883009
ICD10 via Orphanet26 K13.5
ICD1025 K13.5

Related Diseases for Oral Submucous Fibrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.1MMP1, BIRC5, KRT17, GSTM1, GSTT1, CYP1A1
2gingivitis30.5TIMP1, CST3, MMP8, MMP1
3diabetes mellitus30.3MMP3, NAT2, CST3, CTLA4
4periodontitis30.3TIMP1, MMP8, MMP3, LTA, MMP1
5transitional cell carcinoma30.3GSTM1, NAT2, BIRC5, GSTT1
6burns10.4
7verrucous carcinoma10.4
8burning mouth syndrome10.4
9pemphigus10.4
10papilloma10.4
11ankylosis10.2
12cellulitis10.2
13oral mucosa leukoplakia10.2
14disseminated intravascular coagulation10.2
15lipodystrophy10.2
16hypertension10.0CST3
17basal cell carcinoma10.0KRT17
18keratosis10.0LOR
19thyroiditis10.0CTLA4
20cerebral palsy10.0MMP8
21lupus erythematosus10.0NAT2
22malignant mesothelioma10.0NAT2
23essential hypertension10.0CST3
24colon adenocarcinoma10.0LOX
25migraine10.0GSTM1
26dilated cardiomyopathy10.0MMP1
27tuberculosis10.0NAT2
28peritonitis10.0MMP8
29bronchiolitis obliterans10.0MMP8
30primary hyperoxaluria10.0CST3
31ehlers-danlos syndrome10.0COL1A2
32myocardial infarction10.0CST3, GSTT1
33connective tissue disease10.0CTLA4
34cleft palate10.0GSTM1
35polycythemia vera10.0TIMP1
36malaria10.0GSTM1
37vitiligo10.0CTLA4
38thyroid cancer10.0GSTT1, GSTM1
39malignant glioma10.0BIRC5
40cleft lip10.0GSTM1
41cerebrovascular disease10.0CST3
42dermatitis10.0LOR, CTLA4
43bladder carcinoma10.0LTA
44primary open angle glaucoma10.0GSTM1
45polycythemia10.0TIMP1
46sarcoidosis10.0LTA
47schistosomiasis10.0GSTM1
48sarcoma10.0LOX, GSTM1
49nephritis10.0LTA
50kawasaki disease10.0MMP3, TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Clinical Features for Oral Submucous Fibrosis

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Sources:
48Orphanet
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Symptoms:

48
  • limited opening of the mouth
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • anomaly of the pharynx/pharyngeal anomaly
  • anomalies of tongue, gingiva and oral mucosa
  • oral mucosa disease/cheilitis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos

Drugs & Therapeutics for Oral Submucous Fibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Submucous Fibrosis

Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Search CenterWatch for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Oral Submucous Fibrosis:

32
Tongue, Skin, Salivary gland, Endothelial, T cells, Liver, Testes

Animal Models for Oral Submucous Fibrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9GSTT1, NAT2, LTA, CTLA4, CST3, LOX

Publications for Oral Submucous Fibrosis

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Sources:
50PubMed
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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 384)
idTitleAuthorsYear
1
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
2
Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease. (22972608)
2013
3
Oral submucous fibrosis at pediatric age, now time to think: Series of two cases. (24049299)
2013
4
Psychiatric morbidity among patients with oral submucous fibrosis: a controlled study. (23756424)
2013
5
Evaluation of inter incisal mouth opening for airway maintenance in oral submucous fibrosis. (23997480)
2012
6
Use of buccal fat pad for treatment of oral submucous fibrosis. (21549481)
2012
7
Increased expression of CK8 and CK18 in leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma: an immunohistochemistry study. (22677743)
2012
8
Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer--a comparative study. (23167351)
2012
9
A prospective transmission electron microscopic study of muscle status in oral submucous fibrosis along with retrospective analysis of 80 cases of oral submucous fibrosis. (23248458)
2012
10
Endodontic management of a patient with oral submucous fibrosis using custom modified endodontic instruments. (22368345)
2012
11
Computer vision approach to morphometric feature analysis of basal cell nuclei for evaluating malignant potentiality of oral submucous fibrosis. (21152957)
2012
12
Extended nasolabial flaps in the management of oral submucous fibrosis. (22942590)
2011
13
I+4I^1 integrin-dependent cell sorting dictates T-cell recruitment in oral submucous fibrosis. (22144828)
2011
14
Evaluation of oral submucous fibrosis using ultrasonographic technique: a new diagnostic tool. (22124047)
2011
15
Using toluidine blue as an adjunct to oral visual cancer screening among high-risk individuals may lead to increased detection of oral submucous fibrosis. (22078834)
2011
16
Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral submucous fibrosis. (21525689)
2011
17
Role of TGF-I^ and BMP7 in the pathogenesis of oral submucous fibrosis. (21591998)
2011
18
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
19
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
20
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
21
Correlation of addictive factors, human papilloma virus infection and histopathology of oral submucous fibrosis. (20070487)
2010
22
Physiotherapeutic treatment improves oral opening in oral submucous fibrosis. (18673417)
2009
23
Expression of loricrin and cytochrome P450 3A5 in oral submucous fibrosis and their significance]. (19323390)
2009
24
Comparative study of clinicofunctional staging of oral submucous fibrosis with qualitative analysis of collagen fibers under polarizing microscopy. (19884707)
2009
25
Drug treatment of oral submucous fibrosis: a review of the literature. (19531426)
2009
26
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
27
The upregulation of cystatin C in oral submucous fibrosis. (17070095)
2007
28
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
29
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
30
Cytokeratin expression in oral submucous fibrosis--an immunohistochemical study. (16393250)
2006
31
Pentoxifylline therapy: a new adjunct in the treatment of oral submucous fibrosis. (17217216)
2006
32
The chewing of betel quid and oral submucous fibrosis and anesthesia. (15781548)
2005
33
Oral submucous fibrosis: a case-control study in Chennai, South India. (15078487)
2004
34
Cytological study of copper in oral submucous fibrosis. (16035640)
2004
35
PLS-ANN based classification model for oral submucous fibrosis and oral carcinogenesis. (12696101)
2003
36
Histologic examination of pedicled buccal fat pad graft in oral submucous fibrosis. (12378485)
2002
37
Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis. (11854068)
2002
38
Malignant potential of oral submucous fibrosis due to intraoral trauma. (11216327)
2000
39
Expression of p53 protein in oral submucous fibrosis, oral epithelial hyperkeratosis, and oral epithelial dysplasia. (10820956)
2000
40
The fibroblast population in oral submucous fibrosis. (9049905)
1997
41
Morphometric analysis of spinous cell in oral submucous fibrosis. Comparison with normal mucosa, leukoplakia and squamous cell carcinoma. (7555236)
1995
42
HLA-antigens in oral submucous fibrosis. (8138977)
1994
43
Electrogustometry in oral submucous fibrosis. A study in 50 cases. (1343962)
1992
44
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
45
Oral submucous fibrosis. A review with case reports. (3555737)
1987
46
Estimation of complement C3 in oral submucous fibrosis. (3125276)
1987
47
Regional variations in oral submucous fibrosis in India. (3476249)
1987
48
Oral submucous fibrosis as a precancerous lesion. (6964201)
1982
49
A new ultrastructural finding in oral submucous fibrosis. (5018680)
1972
50
Frequency of oral submucous fibrosis in North India. (5294187)
1965

Genetic Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 51QIAGEN
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Pathways related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CTLA4
210.3GSTT1, GSTM1
310.3GSTT1, GSTM1
410.3COL1A2, LOX
5
Hide members
10.3CYP1A1, CYP3A5
6
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.2MMP1, MMP3, TIMP1
7
Naphthalene metabolism
Hide members
10.2GSTT1, GSTM1, CYP1A1
8
Hide members
10.2MMP1, MMP8, MMP3, TIMP1
9
Hide members
10.2CYP1A1, CYP3A5, NAT2
10
Hide members
10.1COL1A2, TIMP1, MMP3, MMP8
11
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
12
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
13
Hide members
10.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
14
Cell adhesion ECM remodeling
Hide members
10.0MMP1, MMP8, MMP3, CST3, TIMP1, COL1A2

Compounds for genes affiliated with Oral Submucous Fibrosis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.8LOX
2procollagen4410.7COL1A2
3pge24410.6BIRC5
4(4-aminophenyl)mercuric acetate4410.6TIMP1, MMP3, MMP8
5drugs for treatment of tuberculosis4910.6GSTT1, GSTM1, NAT2
6alpha tocopherol4410.5CYP1A1, GSTM1
71-hydroxypyrene4410.5GSTM1, GSTT1, NAT2, CYP1A1
8hydroxamate4410.5TIMP1, MMP3, MMP8, MMP1
9sulfonamide4410.5GSTM1, MMP1, MMP3, NAT2
10benzene4410.5GSTT1, XRCC3, GSTM1, NAT2
11marimastat44 59 1112.4MMP1, MMP8, MMP3, TIMP1
12aflatoxin b144 2411.4CYP3A5, GSTM1, GSTT1, NAT2
13infliximab44 49 1112.4TIMP1, MMP1, MMP3, LTA, CTLA4
14rsai4410.4COL1A2, GSTM1, GSTT1, NAT2
15h2o24410.4LTA, CYP1A1, LOX, MMP1, MMP8
16mspi4410.4NAT2, CYP1A1, GSTT1, COL1A2, GSTM1
17hydrocarbons4410.4NAT2, CYP1A1, GSTM1, GSTT1
18folate4410.4TIMP1, XRCC3, CST3, NAT2, GSTM1, GSTT1
19alendronate44 49 1112.4MMP1, TIMP1, MMP3, MMP8
20curcumin4410.4LOX, BIRC5, CYP1A1, MMP1, MMP3, TIMP1
21cyclosporin a44 28 5912.3CST3, CTLA4, LTA, CYP3A5, MMP1, MMP8
22glycosaminoglycan4410.3LOX, MMP3, MMP8, TIMP1, MMP1
23vitamin a44 11 2412.3MMP1, BIRC5, LOR, NAT2, CYP1A1, CST3
24quinacrine44 1111.3LOX, CYP3A5, MMP3, MMP1
25mifepristone44 59 28 1113.3CYP3A5, MMP3, MMP1, BIRC5, TIMP1
26thalidomide44 49 59 1113.3BIRC5, NAT2, CYP3A5, CYP1A1, CTLA4
27p0034410.3GSTT1, GSTM1, LTA, CST3, XRCC3
28uva 14410.2MMP1, MMP3, TIMP1
29paraffin4410.2LOX, MMP3, KRT17, BIRC5, MMP1, LTA
30n acetylcysteine4410.2CST3, CYP1A1, MMP3, MMP1, BIRC5, XRCC3
31oxygen44 2411.2MMP8, CYP3A5, LOX, BIRC5, GSTM1, CYP1A1
32gsts4410.2GSTT1, GSTM1, CYP1A1, NAT2
33cisplatin44 49 59 1113.2BIRC5, GSTT1, LOX, XRCC3, GSTM1, CYP1A1
34p0024410.2TIMP1, CTLA4, CST3, MMP3, BIRC5, GSTM1
35methotrexate44 49 1112.2MMP1, NAT2, CST3, TIMP1, CTLA4, MMP3
36etanercept44 49 1112.1MMP1, MMP3, TIMP1, LTA
37troglitazone44 28 59 1113.1CYP1A1, CYP3A5, MMP1, BIRC5
38dexamethasone44 49 28 1113.1LOX, TIMP1, CTLA4, CYP1A1, CYP3A5, NAT2
39ascorbic acid44 2411.1GSTT1, LOX, GSTM1, CYP1A1, MMP3, MMP1
40vegf4410.1LTA, MMP1, MMP8, MMP3, TIMP1, BIRC5
41cholesterol44 28 11 2413.1MMP3, CTLA4, NAT2, LTA, BIRC5, LOR
42progesterone44 59 28 11 2414.1MMP8, BIRC5, MMP1, MMP3, NAT2, CYP3A5
43lactate4410.0MMP8, MMP1, MMP3, LOX, BIRC5, GSTM1
44oligonucleotide4410.0GSTT1, KRT17, BIRC5, MMP1, MMP8, NAT2
45cysteine4410.0MMP3, LOX, MMP8, COL1A2, TIMP1, CST3
46serine4410.0LTA, TTK, KRT17, CTLA4, TIMP1, COL1A2
47lipid449.9LOR, LOX, CST3, CTLA4, CYP3A5, LTA
48retinoic acid44 2410.9LTA, CYP3A5, CYP1A1, TIMP1, LOX, MMP8
49vitamin d449.9MMP3, LTA, GSTM1, COL1A2, CTLA4
50batimastat44 59 1111.9TIMP1, MMP3, MMP8, MMP1

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9COL1A2, TIMP1, CST3, MMP3, MMP8, MMP1
2extracellular spaceGO:0056159.5MMP8, LOX, COL1A2, CST3, LTA, MICA

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249310.1GSTT1, CYP1A1, LTA, LOX
2extracellular matrix disassemblyGO:02261710.1MMP1, MMP8, MMP3, TIMP1, COL1A2
3extracellular matrix organizationGO:03019810.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
4xenobiotic metabolic processGO:0068059.9CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
5collagen catabolic processGO:0305749.8COL1A2, MMP3, MMP8, MMP1

Products for genes affiliated with Oral Submucous Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Submucous Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet