MCID: ORL004
MIFTS: 48

Oral Submucous Fibrosis malady

Rare diseases, Gastrointestinal diseases, Oral diseases categories

Summaries for Oral Submucous Fibrosis

About this section


Wikipedia:63 Oral submucous fibrosis (OSMF) is a chronic, complex potential potent pre-cancerous ( appox 20% may have... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral cancer and periodontitis, and has symptoms including abnormality of the oral cavity, trismus and abnormality of the pharynx. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Matrix Metalloproteinases. The compounds uva 1 and latanoprost have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and liver, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

About this section
Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 55SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Oral Submucous Fibrosis, Aliases & Descriptions:

Name: Oral Submucous Fibrosis 9 41 11 43 47 60
Oral Submucosal Fibrosis, Including of Tongue 9 60
Oral Cavity Submucous Fibrosis 9
 
Oral Submucosal Fibrosis 9
Osmf 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

47
oral submucous fibrosis:
Age of onset: All ages


External Ids:

Disease Ontology9 DOID:5773
NCIt38 C34866
ICD9CM27 528.8
SNOMED-CT55 32883009
Orphanet47 357154
ICD10 via Orphanet26 K13.5
ICD1025 K13.5

Related Diseases for Oral Submucous Fibrosis

About this section

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.1GSTT1, MMP1
2periodontitis30.9MMP8
3gingivitis30.2MMP1, CST3, MMP8, TIMP1
4leukoplakia10.8
5oral squamous cell carcinoma10.8
6oral leukoplakia10.7
7burns10.5
8pemphigus10.5
9pemphigus vulgaris10.4
10burning mouth syndrome10.4
11verrucous carcinoma10.4
12papilloma10.4
13localized scleroderma10.3LOX, MMP1
14conjunctivochalasis10.3MMP1, TIMP1
15pulpitis10.3TIMP1, MMP1
16hypertrophic scars10.2MMP1, TIMP1
17muscle hypertrophy10.2
18adenomatous polyposis coli10.2
19ankylosis10.2
20cellulitis10.2
21disseminated intravascular coagulation10.2
22laryngitis10.2
23lipodystrophy10.2
24endotheliitis10.2
25aggressive periodontitis10.2MMP1, MMP8
26chronic ulcer of skin10.2MMP1, MMP8
27pulmonary emphysema10.2MMP1, MMP8
28arthropathy10.2MMP1, TIMP1
29open-angle glaucoma10.2GSTT1, MMP1
30gingival overgrowth10.2TIMP1, LOX, MMP1
31pulmonary fibrosis10.1LOX, TIMP1, MMP1
32systemic scleroderma10.1TIMP1, MMP1, LOX
33pulmonary fibrosis, idiopathic10.1TIMP1, MMP1
34laryngeal squamous cell carcinoma10.1GSTT1, MMP1
35keloids10.1LOX, MMP1, MMP8
36keratoconus10.1MMP8, TIMP1, MMP1
37skin disease10.1MMP1, LOX, LOR
38synovitis10.1TIMP1, MMP8, MMP1
39periodontal disease10.1MMP1, MMP8, TIMP1
40ovarian cancer, somatic10.1TIMP1, LOX, GSTT1
41endometriosis10.1TIMP1, GSTT1, MMP1
42osteosarcoma, somatic10.1MMP1, TIMP1, LOX
43nicotine dependence, protection against10.0GSTT1, XRCC3
44osteoarthritis10.0TIMP1, MMP8, MMP1
45xeroderma pigmentosum, variant type10.0GSTT1, XRCC3
46arthritis10.0TIMP1, MMP8, MMP1
47basal cell carcinoma10.0XRCC3, MMP1, GSTT1
48congenital heart disease9.9CST3, MMP1, TIMP1
49squamous cell carcinoma, head and neck9.9LOX, MMP1, TIMP1, GSTT1
50fibrosarcoma9.9TIMP1, CST3, MMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

About this section

Symptoms:

 47
  • limited opening of the mouth
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oropharyngeal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

Drugs & Therapeutics for Oral Submucous Fibrosis

About this section

Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

About this section

Anatomical Context for Oral Submucous Fibrosis

About this section

MalaCards organs/tissues related to Oral Submucous Fibrosis:

31
Tongue, Skin, Liver, Salivary gland, Testes, T cells, Endothelial

Animal Models for Oral Submucous Fibrosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CST3, MMP1, MMP8, TIMP1
2MP:00053767.2GSTT1, TIMP1, MMP1, LOX, LOR, CST3

Publications for Oral Submucous Fibrosis

About this section

Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
2
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
3
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
4
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
5
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
6
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
7
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
8
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
9
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
10
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
11
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
12
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
13
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
14
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
15
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
16
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
17
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
18
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
19
Oral submucous fibrosis in a young patient. (20043056)
2009
20
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
21
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
22
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
23
Interventions for the management of oral submucous fibrosis. (18843745)
2008
24
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
25
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
26
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
27
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
28
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
29
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
30
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
31
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
32
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
33
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
34
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
35
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
36
Raised tissue copper levels in oral submucous fibrosis. (10890553)
2000
37
Oral submucous fibrosis in paediatric age group. (23119548)
1999
38
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
39
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
40
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
41
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
42
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
Oral submucous fibrosis. (3864703)
1985
45
HLA-typing in oral submucous fibrosis. (3864289)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

About this section

Expression for genes affiliated with Oral Submucous Fibrosis

About this section
Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

About this section

Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TIMP1, MMP1
2
Show member pathways
9.2MMP1, MMP8, TIMP1
3
Show member pathways
8.8LOX, TIMP1, MMP8, MMP1
4
Show member pathways
Metalloproteases in connective tissue degradation
8.3CST3, TIMP1, MMP8, MMP1

Compounds for genes affiliated with Oral Submucous Fibrosis

About this section

Compounds related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1uva 14310.1TIMP1, MMP1
2latanoprost43 1211.0TIMP1, MMP1
3grgdsp4310.0MMP1, TIMP1
4nimesulide43 1211.0MMP1, TIMP1
5u01264310.0TIMP1, MMP1
6lutein439.9MMP1, TIMP1
7hocl439.9TIMP1, MMP8
8clodronate43 49 1211.8MMP1, MMP8
9hydroxyproline43 24 1211.8TIMP1, MMP1, LOX
10kt 572043 59 2811.8MMP1, TIMP1
11pyridinoline439.8TIMP1, LOX
12procollagen439.7TIMP1, MMP1, LOX
13alpha tocopherol439.7MMP1, LOX, TIMP1
14uk 383367599.7MMP8, MMP1
15gm 6001599.7MMP1, MMP8
16carbon439.7MMP1, TIMP1, LOX
17curcumin439.7LOX, TIMP1, MMP1
18gi 254023x599.7MMP1, MMP8
19prostaglandin439.7MMP1, TIMP1, LOX
20(4-aminophenyl)mercuric acetate439.6MMP1, MMP8, TIMP1
21hydroxamate439.6MMP8, TIMP1, MMP1
22marimastat43 59 1211.6TIMP1, MMP1, MMP8
23aspirin43 49 28 2412.6LOX, TIMP1, MMP1
24alendronate43 49 1211.6MMP8, MMP1, TIMP1
25batimastat43 59 1211.6MMP8, TIMP1, MMP1
26doxycycline43 1210.6TIMP1, MMP1, MMP8
27indomethacin43 28 59 1212.3LOX, MMP1, TIMP1
28glycosaminoglycan439.3LOX, MMP1, MMP8, TIMP1
29aprotinin43 1210.3TIMP1, MMP1, CST3
30benzene439.2GSTT1, XRCC3
31pge2439.2TIMP1, LOX, MMP8, MMP1
32h2o2439.2MMP8, MMP1, LOX, TIMP1
33urea43 24 1211.1MMP8, CST3, LOX
34methotrexate49 43 1211.1TIMP1, MMP1, CST3
35matrigel438.9LOX, MMP1, TIMP1, CST3
36ascorbic acid43 249.9GSTT1, LOX, MMP1
37p003438.9XRCC3, GSTT1, CST3
38vitamin a43 24 1210.8TIMP1, MMP1, LOR, CST3
39dexamethasone43 49 28 1211.8MMP1, CST3, LOX, TIMP1
40retinoic acid43 249.8TIMP1, MMP8, LOX, LOR, MMP1
41cyclosporin a43 28 5910.7TIMP1, CST3, MMP8, MMP1
42p002438.7GSTT1, MMP8, TIMP1, CST3
43folate438.6GSTT1, TIMP1, CST3, XRCC3
44lactate438.4CST3, LOX, MMP1, MMP8, TIMP1
45vegf438.4CST3, LOX, MMP1, MMP8, TIMP1
46cysteine438.4CST3, LOX, MMP8, TIMP1, MMP1
47n acetylcysteine438.4MMP1, XRCC3, CST3, LOX, TIMP1
48cisplatin43 49 59 1211.2GSTT1, XRCC3, CST3, LOX, TIMP1
49serine438.2MMP8, MMP1, CST3, LOR, TIMP1
50lipid438.2MMP8, GSTT1, LOX, LOR, CST3

GO Terms for genes affiliated with Oral Submucous Fibrosis

About this section

Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.0CST3, LOX, MMP1, MMP8, TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endopeptidase activityGO:00109519.3CST3, TIMP1
2collagen catabolic processGO:00305749.2MMP1, MMP8
3extracellular matrix disassemblyGO:00226179.1TIMP1, MMP8, MMP1
4extracellular matrix organizationGO:00301988.8LOX, MMP1, MMP8, TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.3CST3, TIMP1

Products for genes affiliated with Oral Submucous Fibrosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Oral Submucous Fibrosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet