OSMF
MCID: ORL004
MIFTS: 55

Oral Submucous Fibrosis (OSMF) malady

Rare diseases, Gastrointestinal diseases, Oral diseases categories
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Summaries for Oral Submucous Fibrosis

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Wikipedia:65 Oral submucous fibrosis (OSMF) is a chronic, complex potential potent pre-cancerous ( appox 20% may have... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral cancer and periodontitis, and has symptoms including limited opening of the mouth, oral mucosa disease/cheilitis and anomalies of tongue, gingiva and oral mucosa. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Matrix Metalloproteinases. The compounds uva 1 and latanoprost have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and liver, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 27ICD9CM, 57SNOMED-CT, 26ICD10 via Orphanet, 25ICD10
See all sources

Oral Submucous Fibrosis, Aliases & Descriptions:

Name: Oral Submucous Fibrosis 8 42 10 44 48 62
Oral Submucosal Fibrosis, Including of Tongue 8 62
Oral Submucosal Fibrosis 8 62
 
Oral Cavity Submucous Fibrosis 8
Osmf 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

48
oral submucous fibrosis:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:5773
NCIt39 C34866
ICD9CM27 528.8
SNOMED-CT57 32883009
ICD10 via Orphanet26 K13.5
ICD1025 K13.5

Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.1GSTT1, MMP1
2periodontitis30.9MMP8
3gingivitis30.2TIMP1, MMP8, MMP1, CST3
4leukoplakia10.8
5oral squamous cell carcinoma10.7
6oral leukoplakia10.7
7burns10.5
8pemphigus10.4
9burning mouth syndrome10.4
10verrucous carcinoma10.4
11papilloma10.4
12localized scleroderma10.3LOX, MMP1
13conjunctivochalasis10.3MMP1, TIMP1
14pulpitis10.3TIMP1, MMP1
15diabetes mellitus10.2
16pemphigus vulgaris10.2
17ankylosis10.2
18cellulitis10.2
19disseminated intravascular coagulation10.2
20lipodystrophy10.2
21endotheliitis10.2
22hypertrophic scars10.2TIMP1, MMP1
23aggressive periodontitis10.2MMP1, MMP8
24pulmonary emphysema10.2MMP1, MMP8
25open-angle glaucoma10.2GSTT1, MMP1
26arthropathy10.2TIMP1, MMP1
27gingival overgrowth10.2LOX, MMP1, TIMP1
28pulmonary fibrosis10.2TIMP1, MMP1, LOX
29systemic scleroderma10.1LOX, MMP1, TIMP1
30idiopathic pulmonary fibrosis10.1MMP1, TIMP1
31laryngeal squamous cell carcinoma10.1MMP1, GSTT1
32keloids10.1LOX, MMP1, MMP8
33keratoconus10.1MMP1, MMP8, TIMP1
34skin disease10.1MMP1, LOX, LOR
35synovitis10.1TIMP1, MMP8, MMP1
36periodontal disease10.1MMP1, MMP8, TIMP1
37ovarian cancer10.1GSTT1, LOX, TIMP1
38endometriosis10.1TIMP1, MMP1, GSTT1
39osteosarcoma10.1LOX, MMP1, TIMP1
40osteoarthritis10.0MMP1, MMP8, TIMP1
41xeroderma pigmentosum10.0XRCC3, GSTT1
42arthritis10.0TIMP1, MMP8, MMP1
43basal cell carcinoma10.0GSTT1, XRCC3, MMP1
44congenital heart disease9.9CST3, MMP1, TIMP1
45squamous cell carcinoma of the head and neck9.9TIMP1, MMP1, LOX, GSTT1
46fibrosarcoma9.9CST3, MMP1, TIMP1
47aneurysm9.9CST3, LOX, MMP8
48breast cancer9.9TIMP1, MMP1, LOX, GSTT1
49asthma9.9TIMP1, MMP8, LOX, GSTT1
50chronic obstructive pulmonary disease9.9GSTT1, MMP1, MMP8, TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Symptoms:

48
  • limited opening of the mouth
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oropharyngeal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

32
Tongue, Skin, Liver, Salivary gland, Testes, T cells, Endothelial

Animal Models for Oral Submucous Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CST3, MMP1, MMP8, TIMP1
2MP:00053767.2GSTT1, TIMP1, MMP1, LOX, LOR, CST3

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
2
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
3
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
4
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
5
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
6
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
7
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
8
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
9
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
10
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
11
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
12
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
13
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
14
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
15
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
16
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
17
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
18
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
19
Oral submucous fibrosis in a young patient. (20043056)
2009
20
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
21
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
22
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
23
Interventions for the management of oral submucous fibrosis. (18843745)
2008
24
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
25
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
26
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
27
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
28
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
29
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
30
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
31
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
32
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
33
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
34
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
35
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
36
Raised tissue copper levels in oral submucous fibrosis. (10890553)
2000
37
Oral submucous fibrosis in paediatric age group. (23119548)
1999
38
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
39
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
40
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
41
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
42
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
Oral submucous fibrosis. (3864703)
1985
45
HLA-typing in oral submucous fibrosis. (3864289)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Expression patterns in normal tissues for genes affiliated with Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Compounds for genes affiliated with Oral Submucous Fibrosis

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Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1uva 14410.1MMP1, TIMP1
2latanoprost44 1111.0MMP1, TIMP1
3grgdsp4410.0TIMP1, MMP1
4nimesulide44 1111.0TIMP1, MMP1
5u01264410.0MMP1, TIMP1
6lutein449.9TIMP1, MMP1
7hocl449.9TIMP1, MMP8
8clodronate44 50 1111.8MMP8, MMP1
9hydroxyproline44 24 1111.8LOX, MMP1, TIMP1
10kt 572044 61 2811.8MMP1, TIMP1
11pyridinoline449.8TIMP1, LOX
12procollagen449.7LOX, MMP1, TIMP1
13alpha tocopherol449.7LOX, MMP1, TIMP1
14uk 383367619.7MMP8, MMP1
15gi 254023x619.7MMP8, MMP1
16carbon449.7LOX, MMP1, TIMP1
17curcumin449.7LOX, MMP1, TIMP1
18gm 6001619.7MMP8, MMP1
19prostaglandin449.7TIMP1, MMP1, LOX
20(4-aminophenyl)mercuric acetate449.6TIMP1, MMP8, MMP1
21hydroxamate449.6MMP1, MMP8, TIMP1
22marimastat44 61 1111.6TIMP1, MMP8, MMP1
23aspirin44 50 28 2412.6LOX, MMP1, TIMP1
24alendronate44 50 1111.6MMP1, MMP8, TIMP1
25batimastat44 61 1111.6TIMP1, MMP8, MMP1
26doxycycline44 1110.6TIMP1, MMP8, MMP1
27indomethacin44 28 61 1112.3LOX, MMP1, TIMP1
28glycosaminoglycan449.3TIMP1, MMP8, MMP1, LOX
29aprotinin44 1110.3TIMP1, MMP1, CST3
30benzene449.2GSTT1, XRCC3
31pge2449.2TIMP1, MMP8, MMP1, LOX
32h2o2449.2TIMP1, MMP8, MMP1, LOX
33urea44 24 1111.1MMP8, LOX, CST3
34methotrexate50 44 1111.1CST3, MMP1, TIMP1
35matrigel448.9TIMP1, MMP1, LOX, CST3
36ascorbic acid44 249.9GSTT1, LOX, MMP1
37p003448.9XRCC3, CST3, GSTT1
38vitamin a44 24 1110.8TIMP1, MMP1, LOR, CST3
39dexamethasone44 50 28 1111.8CST3, LOX, MMP1, TIMP1
40retinoic acid44 249.8LOR, LOX, MMP1, MMP8, TIMP1
41cyclosporin a44 28 6110.7TIMP1, MMP8, MMP1, CST3
42p002448.7GSTT1, CST3, MMP8, TIMP1
43folate448.6TIMP1, XRCC3, CST3, GSTT1
44lactate448.4TIMP1, MMP8, MMP1, LOX, CST3
45vegf448.4TIMP1, MMP8, MMP1, LOX, CST3
46cysteine448.4TIMP1, MMP8, MMP1, LOX, CST3
47n acetylcysteine448.4CST3, XRCC3, LOX, MMP1, TIMP1
48cisplatin44 50 61 1111.2GSTT1, CST3, XRCC3, LOX, TIMP1
49serine448.2TIMP1, MMP8, MMP1, LOR, CST3
50lipid448.2GSTT1, CST3, LOR, LOX, MMP8

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0CST3, LOX, MMP1, MMP8, TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endopeptidase activityGO:0109519.3CST3, TIMP1
2collagen catabolic processGO:0305749.2MMP1, MMP8
3extracellular matrix disassemblyGO:0226179.1TIMP1, MMP8, MMP1
4extracellular matrix organizationGO:0301988.8LOX, MMP1, MMP8, TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3CST3, TIMP1

Products for genes affiliated with Oral Submucous Fibrosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Oral Submucous Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet