MCID: ORL004
MIFTS: 51

Oral Submucous Fibrosis

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Submucous Fibrosis

MalaCards integrated aliases for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 12 50 56 52 42 14 69
Oral Submucosal Fibrosis, Including of Tongue 12 69
Osmf 50 56
Oral Cavity Submucous Fibrosis 12
Oral Submucosal Fibrosis 12

Characteristics:

Orphanet epidemiological data:

56
oral submucous fibrosis
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:5773
ICD10 33 K13.5
ICD9CM 35 528.8
MeSH 42 D009914
NCIt 47 C34866
SNOMED-CT 64 32883009
Orphanet 56 ORPHA357154
UMLS via Orphanet 70 C0029172
ICD10 via Orphanet 34 K13.5

Summaries for Oral Submucous Fibrosis

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 357154disease definitionoral submucous fibrosis (osmf) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cellcancer (3-19%). it is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.visit the orphanet disease page for more resources. last updated: 7/16/2013

MalaCards based summary : Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to basedow's coma and asbestos intoxication, and has symptoms including narrow mouth, abnormality of the oral cavity and trismus. An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Hyaluronic acid and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, premalignant (1% transformation risk)... more...

Related Diseases for Oral Submucous Fibrosis

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 basedow's coma 10.6 CYP1A1 GSTT1
2 asbestos intoxication 10.5 GSTM1 GSTT1
3 orbital lymphoma 10.5 GSTM1 GSTT1
4 squamous cell carcinoma 10.5
5 leukoplakia 10.4
6 oral squamous cell carcinoma 10.4
7 emery-dreifuss muscular dystrophy, dominant type 10.4 GSTM1 GSTT1
8 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.4 CYP1A1 GSTM1
9 congenital leptin deficiency 10.3 CYP1A1 PTGS2
10 mucositis 10.3
11 oral leukoplakia 10.3
12 adenosine monophosphate deaminase 1 deficiency 10.3 MMP2 PTGS2
13 oral cancer 10.3
14 thrombophlebitis migrans 10.3 GSTM1 TGFB1
15 cecum adenoma 10.2 MMP2 TIMP1
16 levy-yeboa syndrome 10.2 CYP1A1 GSTM1 GSTT1
17 spindle epithelial tumor with thymus-like differentiation tumor 10.2 MMP2 TIMP1
18 gait apraxia 10.2 MMP2 TIMP1
19 measles 10.2 CYP1A1 GSTM1 GSTT1
20 charcot-marie-tooth disease, axonal, type 2cc 10.2 MMP2 TIMP1
21 osteochondrosis 10.2 PTGS2 TGFB1 TIMP1
22 colon squamous cell carcinoma 10.2 MMP2 TIMP1
23 hepatocellular adenoma 10.2 GSTM1 GSTT1
24 gastrointestinal tularemia 10.2 GSTM1 GSTT1
25 congenital methemoglobinemia 10.1 MMP2 TGFB1 TIMP1
26 cholera 10.1 TGFB1 TIMP1
27 chronic inflammatory demyelinating polyradiculoneuropathy 10.0 CDH1 PTGS2 TGFB1
28 salt and pepper syndrome 10.0 MMP2 TGFB1 TIMP1
29 spinal cord intramedullary teratoma 10.0 LOX MMP2 TIMP1
30 burns 10.0
31 verrucous carcinoma 10.0
32 pemphigus 10.0
33 hepatic flexure cancer 10.0 GSTM1 GSTT1 MMP2
34 immunodeficiency 27b, mycobacteriosis, ad 10.0 CDH1 PTGS2 TIMP1
35 diffuse mesangial sclerosis 9.9 CDH1 GSTM1 GSTT1
36 pemphigus vulgaris 9.9
37 papilloma 9.9
38 gingivitis 9.9
39 burning mouth syndrome 9.9
40 mycetoma 9.9 GSTM1 GSTT1
41 gallbladder cancer 9.8 CDH1 MMP2 PTGS2
42 nail disorder, nonsyndromic congenital, 1 9.8 CDH1 MMP2 PTGS2
43 acute pancreatitis 9.8 GSTM1 GSTT1 MMP2 PTGS2
44 villous adenoma 9.8 CDH1 MMP2 PTGS2
45 muscle hypertrophy 9.8
46 adenomatous polyposis coli 9.8
47 deficiency anemia 9.8
48 disseminated intravascular coagulation 9.8
49 iron deficiency anemia 9.8
50 ankylosis 9.8

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to Oral Submucous Fibrosis

Symptoms & Phenotypes for Oral Submucous Fibrosis

Human phenotypes related to Oral Submucous Fibrosis:

56 32 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 narrow mouth 56 32 hallmark (90%) Very frequent (99-80%) HP:0000160
2 abnormality of the oral cavity 56 32 hallmark (90%) Very frequent (99-80%) HP:0000163
3 trismus 56 32 frequent (33%) Frequent (79-30%) HP:0000211
4 abnormality of the pharynx 56 32 hallmark (90%) Very frequent (99-80%) HP:0000600
5 flexion contracture 56 32 frequent (33%) Frequent (79-30%) HP:0001371
6 oropharyngeal squamous cell carcinoma 56 32 occasional (7.5%) Occasional (29-5%) HP:0012182
7 cheilitis 56 32 hallmark (90%) Very frequent (99-80%) HP:0100825

UMLS symptoms related to Oral Submucous Fibrosis:


oral manifestations

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 CDH1 CYP1A1 LOX MMP2 PTGS2 SFRP4
2 homeostasis/metabolism MP:0005376 9.91 CYP1A1 DKK3 LOX MMP2 PTGS2 SFRP4
3 immune system MP:0005387 9.76 CDH1 CYP1A1 DKK3 MMP2 PTGS2 SFRP4
4 neoplasm MP:0002006 9.35 CDH1 MMP2 PTGS2 TGFB1 TIMP1
5 respiratory system MP:0005388 9.1 LOX MMP2 PTGS2 SFRP4 TGFB1 TIMP1

Drugs & Therapeutics for Oral Submucous Fibrosis

Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741 24759
2
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
3
Butyric Acid Experimental Phase 3 107-92-6 264
4 Adjuvants, Immunologic Phase 3
5 Anti-Inflammatory Agents Phase 3,Phase 2
6 Antioxidants Phase 3
7 Cortisol succinate Phase 3
8 Hydrocortisone 17-butyrate 21-propionate Phase 3
9 Hydrocortisone acetate Phase 3
10 Hydrocortisone-17-butyrate Phase 3
11 Protective Agents Phase 3
12 Viscosupplements Phase 3
13
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
14
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
15
Tegafur Approved Phase 2 17902-23-7 5386
16 tannic acid Approved, Nutraceutical Phase 2
17
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
18
Curcumin Investigational Phase 2 458-37-7 969516
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Antirheumatic Agents Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Antimetabolites Phase 2
25 Antimetabolites, Antineoplastic Phase 2
26 Astragalus Nutraceutical Phase 2
27 Antibodies
28 Autoantibodies
29 Immunoglobulins

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study Completed NCT02714543 Phase 3 aloevera juice;Hydrocortisone;Hyaluronic Acid;antioxidant;aloevera gel
2 Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF) Active, not recruiting NCT02645656 Phase 2 Curcumin Arm
3 A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy Terminated NCT01720563 Phase 2 Astragalus polysaccharides 500 mg;Placebo
4 Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis Completed NCT02711046
5 Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis Recruiting NCT03011086
6 Evaluation of Functional Dimensions of Macintosh Laryngoscope Blade During Direct Laryngoscopy in Patients With Normal Mouth Opening Recruiting NCT02639897

Search NIH Clinical Center for Oral Submucous Fibrosis

Cochrane evidence based reviews: oral submucous fibrosis

Genetic Tests for Oral Submucous Fibrosis

Anatomical Context for Oral Submucous Fibrosis

MalaCards organs/tissues related to Oral Submucous Fibrosis:

39
Tongue, Skin, Endothelial, T Cells, Testes, Salivary Gland, Liver

Publications for Oral Submucous Fibrosis

Articles related to Oral Submucous Fibrosis:

(show top 50) (show all 528)
id Title Authors Year
1
Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry. ( 28826108 )
2018
2
Prosthetic rehabilitation of oral submucous fibrosis patients: A systematic review of published case reports and case series. ( 28877246 )
2017
3
Total Serum Protein Estimation and Its Correlation with Clinical and Histopathological Grading using Masson's Trichrome Stain in Patients of Oral Submucous Fibrosis. ( 28839417 )
2017
4
Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitorA 3, in the malignant progression of oral submucous fibrosis. ( 27959428 )
2017
5
Oral submucous fibrosis-an increasing global healthcare problem. ( 28672092 )
2017
6
Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis By Epigenetically Reactivating the p53 Pathway. ( 28550687 )
2017
7
An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis. ( 28862199 )
2017
8
Identification of I+-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis. ( 28821582 )
2017
9
Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages. ( 28658917 )
2017
10
Breath Alkane as an index of severity for oral submucous fibrosis: A new perspective? ( 28012596 )
2017
11
Developing a quality-of-life questionnaire for oral submucous fibrosis patients. ( 28865104 )
2017
12
Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis. ( 28826174 )
2017
13
Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood. ( 28483252 )
2017
14
Effectiveness of Osteopathic Therapy in the Treatment of Oral Submucous Fibrosis. ( 28566867 )
2017
15
Assessment of anxiety, depression, and serum cortisol level in oral submucous fibrosis patients: A controlled clinical trial. ( 28932136 )
2017
16
Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging. ( 28479685 )
2017
17
Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: A meta-analysis. ( 28737007 )
2017
18
Evaluation of Oral Pentoxifylline in the Management of Oral Submucous Fibrosis - An Ultrasonographic Study. ( 28839403 )
2017
19
Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study. ( 28717289 )
2017
20
Oral submucous fibrosis in a school-going Indian adolescent boy. ( 28731854 )
2017
21
Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without. ( 28606826 )
2017
22
Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis. ( 28761276 )
2017
23
Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis. ( 27910776 )
2016
24
Aberrant DKK3 expression in the oral leukoplakia and oral submucous fibrosis: a comparative immunohistochemical study. ( 27349317 )
2016
25
MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis. ( 27509054 )
2016
26
Efficacy and Safety of Intralesional Xantinol Nicotinate in the Treatment of Various Stages of Oral Submucous Fibrosis. ( 27891454 )
2016
27
Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis. ( 27533088 )
2016
28
Identification of a combined biomarker for malignant transformation in oral submucous fibrosis. ( 27497264 )
2016
29
Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies. ( 27743497 )
2016
30
Aggrandizing oral submucous fibrosis grading using an adjunct special stain: A pilot study. ( 27194860 )
2016
31
Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis. ( 27891461 )
2016
32
Clinical Efficacy of a Mouth-Exercising Device Adjunct to Local Ointment Intra-Lesional Injections and Surgical Treatment for Oral Submucous Fibrosis: a Randomized Controlled Trial. ( 27039756 )
2016
33
Immunohistochemical study of p21 and Bcl-2 in leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. ( 27849339 )
2016
34
Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis. ( 26088962 )
2016
35
Effectiveness of Aloe Vera and Antioxidant along with Physiotherapy in the Management of Oral Submucous Fibrosis. ( 27084867 )
2016
36
Prognostic potential of AgNORs in oral submucous fibrosis. ( 27114958 )
2016
37
Response to Oral epithelial dysplasia in oral submucous fibrosis: A challenge. ( 26786963 )
2016
38
Dental Informatics tool "SOFPRO" for the study of oral submucous fibrosis. ( 27601808 )
2016
39
Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis. ( 27485544 )
2016
40
High risk of malignant transformation of oral submucous fibrosis in Pakistani females: A potential national disaster. ( 27812049 )
2016
41
Bipaddled anterolateral thigh perforator flap for simultaneous reconstruction of bilateral buccal defects following oral cancer ablation or release of oral submucous fibrosis. ( 27619322 )
2016
42
Oral submucous fibrosis: a review of the current management and possible directions for novel therapies. ( 27422422 )
2016
43
Omega 3: a novel treatment agent in oral submucous fibrosis: a pilot study. ( 28027413 )
2016
44
Oral Submucous Fibrosis Secondary to Iron Deficiency Anemia: A Case Report, Etiopathogenesis and Management. ( 26812518 )
2016
45
Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis. ( 27845370 )
2016
46
An Innovative Approach to Evaluate the Morphological Patterns of Soft Palate in Oral Submucous Fibrosis Patients: A Digital Cephalometric Study. ( 27034975 )
2016
47
Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis. ( 27422417 )
2016
48
Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis. ( 27965488 )
2016
49
Characterization of a Novel Dermal Fibrosis Model Induced by Areca Nut Extract that Mimics Oral Submucous Fibrosis. ( 27851781 )
2016
50
Versatility of nasolabial flaps for the management of severe trismus in oral submucous fibrosis. ( 27966506 )
2016

Variations for Oral Submucous Fibrosis

Expression for Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for Oral Submucous Fibrosis

Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1 12.37 CDH1 MMP2 PTGS2 TGFB1
2
Show member pathways
12.37 CDH1 LOX MMP2 TGFB1 TIMP1
3
Show member pathways
12.34 CYP1A1 GSTM1 GSTT1 PTGS2
4 11.84 GSTM1 GSTT1 MMP2
5 11.78 CDH1 MMP2 PTGS2 TGFB1
6 11.51 MMP2 PTGS2 TGFB1 TIMP1
7
Show member pathways
11.48 CYP1A1 GSTM1 GSTT1
8 11.34 MMP2 TGFB1 TIMP1
9
Show member pathways
11.09 CYP1A1 GSTM1
10 11.07 MMP2 TGFB1
11 11 GSTM1 GSTT1
12 10.86 MMP2 PTGS2 TGFB1 TIMP1
13 10.77 DKK3 SFRP4
14 10.75 CDH1 TGFB1
15 10.61 GSTT1 PTGS2
16 10.51 CYP1A1 GSTM1 GSTT1

GO Terms for Oral Submucous Fibrosis

Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 DKK3 LOX MMP2 SFRP4 TGFB1 TIMP1
2 proteinaceous extracellular matrix GO:0005578 8.92 LOX MMP2 TGFB1 TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.71 CYP1A1 MMP2 TGFB1
2 response to organic cyclic compound GO:0014070 9.63 CYP1A1 PTGS2 TGFB1
3 digestive tract development GO:0048565 9.57 CYP1A1 TGFB1
4 face morphogenesis GO:0060325 9.56 MMP2 TGFB1
5 positive regulation of vascular endothelial growth factor production GO:0010575 9.55 PTGS2 TGFB1
6 wound healing GO:0042060 9.54 LOX TGFB1 TIMP1
7 response to immobilization stress GO:0035902 9.52 CYP1A1 TGFB1
8 glutathione derivative biosynthetic process GO:1901687 9.51 GSTM1 GSTT1
9 extracellular matrix disassembly GO:0022617 9.5 CDH1 MMP2 TIMP1
10 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.49 DKK3 TGFB1
11 response to vitamin D GO:0033280 9.48 PTGS2 TGFB1
12 aging GO:0007568 9.46 CYP1A1 PTGS2 TGFB1 TIMP1
13 cell activation GO:0001775 9.43 TGFB1 TIMP1
14 response to hormone GO:0009725 9.43 LOX SFRP4 TIMP1
15 negative regulation of cell-cell adhesion GO:0022408 9.4 CDH1 TGFB1
16 response to drug GO:0042493 9.35 CDH1 CYP1A1 LOX PTGS2 TGFB1
17 response to organic substance GO:0010033 9.02 CDH1 CYP1A1 PTGS2 TGFB1 TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
2 enzyme binding GO:0019899 8.92 CYP1A1 GSTM1 PTGS2 TGFB1

Sources for Oral Submucous Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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