OSMF
MCID: ORL004
MIFTS: 57

Oral Submucous Fibrosis (OSMF) malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Oral Submucous Fibrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition... more...

MalaCards: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to squamous cell carcinoma and gingivitis, and has symptoms including oropharyngeal neoplasm/tumor/carcinoma/cancer, contractures/cramps/trismus/tetania/claudication/opisthotonos and anomaly of the pharynx/pharyngeal anomaly. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Rheumatoid arthritis and Aflatoxin B1 metabolism. The compounds indomethacin and procollagen have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

48
oral submucous fibrosis:
Age of onset: Variable


Aliases & Descriptions:

oral submucous fibrosis 8 42 10 44 48 60
oral submucosal fibrosis, including of tongue 8 60
oral cavity submucous fibrosis 8
oral submucosal fibrosis 8
osmf 48


External Ids:

Disease Ontology8 DOID:5773
ICD9CM27 528.8
NCIt39 C34866
SNOMED-CT56 32883009
ICD10 via Orphanet26 K13.5
ICD1025 K13.5

Related Diseases for Oral Submucous Fibrosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.1MMP1, BIRC5, KRT17, GSTM1, GSTT1, CYP1A1
2gingivitis30.5TIMP1, CST3, MMP8, MMP1
3diabetes mellitus30.3MMP3, NAT2, CST3, CTLA4
4periodontitis30.3TIMP1, MMP8, MMP3, LTA, MMP1
5transitional cell carcinoma30.3GSTM1, NAT2, BIRC5, GSTT1
6burns10.4
7verrucous carcinoma10.4
8burning mouth syndrome10.4
9pemphigus10.4
10papilloma10.4
11ankylosis10.2
12cellulitis10.2
13oral mucosa leukoplakia10.2
14disseminated intravascular coagulation10.2
15lipodystrophy10.2
16hypertension10.0CST3
17basal cell carcinoma10.0KRT17
18keratosis10.0LOR
19thyroiditis10.0CTLA4
20cerebral palsy10.0MMP8
21lupus erythematosus10.0NAT2
22malignant mesothelioma10.0NAT2
23essential hypertension10.0CST3
24colon adenocarcinoma10.0LOX
25migraine10.0GSTM1
26dilated cardiomyopathy10.0MMP1
27tuberculosis10.0NAT2
28peritonitis10.0MMP8
29bronchiolitis obliterans10.0MMP8
30primary hyperoxaluria10.0CST3
31ehlers-danlos syndrome10.0COL1A2
32myocardial infarction10.0CST3, GSTT1
33connective tissue disease10.0CTLA4
34cleft palate10.0GSTM1
35polycythemia vera10.0TIMP1
36malaria10.0GSTM1
37vitiligo10.0CTLA4
38thyroid cancer10.0GSTT1, GSTM1
39malignant glioma10.0BIRC5
40cleft lip10.0GSTM1
41cerebrovascular disease10.0CST3
42dermatitis10.0LOR, CTLA4
43bladder carcinoma10.0LTA
44primary open angle glaucoma10.0GSTM1
45polycythemia10.0TIMP1
46sarcoidosis10.0LTA
47schistosomiasis10.0GSTM1
48sarcoma10.0LOX, GSTM1
49nephritis10.0LTA
50kawasaki disease10.0MMP3, TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Clinical Features for Oral Submucous Fibrosis

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Sources:
48Orphanet
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Symptoms:

48
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • anomaly of the pharynx/pharyngeal anomaly
  • anomalies of tongue, gingiva and oral mucosa
  • oral mucosa disease/cheilitis
  • limited opening of the mouth

Drugs & Therapeutics for Oral Submucous Fibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Submucous Fibrosis

Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Search CenterWatch for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Oral Submucous Fibrosis:

32
Tongue, Skin, Endothelial, T cells, Testes, Salivary gland, Liver

Animal Models for Oral Submucous Fibrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9GSTT1, NAT2, LTA, CTLA4, CST3, LOX

Publications for Oral Submucous Fibrosis

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Sources:
50PubMed
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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 384)
idTitleAuthorsYear
1
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
2
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
3
Burning sensation in oral submucous fibrosis and its possible association with mucin secreted by affected minor salivary glands. (23363930)
2013
4
Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population. (22752755)
2012
5
Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. (22650317)
2012
6
Effect of I+-tocopherol on salivary reactive oxygen species and trace elements in oral submucous fibrosis. (22337705)
2012
7
Betel-quid and oral submucous fibrosis: a cross-sectional study in Hunan province, China. (22607258)
2012
8
Coronoidectomy, masticatory myotomy and buccal fat pad graft in management of advanced oral submucous fibrosis. (22551649)
2012
9
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
10
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study. (21891896)
2011
11
Efficacy of alpha lipoic acid in adjunct with intralesional steroids and hyaluronidase in the management of oral submucous fibrosis. (21358090)
2010
12
Survivin as a potential early marker in the carcinogenesis of oral submucous fibrosis. (20303055)
2010
13
Zinc and vitamin A can minimise the severity of oral submucous fibrosis. (22736755)
2010
14
Retrospective comparison of surgical treatment modalities in 100 patients with oral submucous fibrosis. (19217007)
2009
15
Lipid profile in oral submucous fibrosis. (19630946)
2009
16
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
17
Oral submucous fibrosis: a clinico-histopathological study in Chennai. (17687172)
2007
18
Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka. (18085379)
2007
19
Oral submucous fibrosis: review on aetiology and pathogenesis. (16311067)
2006
20
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
21
Characterisation and quantification of mucosal vasculature in oral submucous fibrosis. (16454321)
2005
22
Molecular pathogenesis of oral submucous fibrosis--a collagen metabolic disorder. (15946178)
2005
23
Facial Candida albicans cellulitis occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment. (15061713)
2004
24
Liver ultrasound and faecal copper estimation in oral submucous fibrosis. (12800753)
2003
25
Evaluation of TGF-alpha and EGFR expression in oral leukoplakia and oral submucous fibrosis by quantitative immunohistochemistry. (11721175)
2001
26
Adenomatous polyposis coli gene mutation and decreased wild-type p53 protein expression in oral submucous fibrosis: a preliminary investigation. (11505268)
2001
27
Quantitative estimation of PCNA, c-myc, EGFR and TGF-alpha in oral submucous fibrosis--an immunohistochemical study. (11377235)
2001
28
The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma. (10426196)
1999
29
Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. (9972171)
1998
30
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
31
Establishing a normal range for mouth opening: its use in screening for oral submucous fibrosis. (9043002)
1997
32
Oral submucous fibrosis. The South African experience. (9495135)
1997
33
Oral submucous fibrosis. A review. (8961601)
1996
34
Oral stent as treatment adjunct for oral submucous fibrosis. (8665305)
1996
35
Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing. (7783003)
1995
36
Immunological studies in oral submucous fibrosis. (9495103)
1994
37
Squamous cell carcinoma arising in a nasolabial flap used in treatment of oral submucous fibrosis. (8087383)
1994
38
Oral submucous fibrosis--a chronic disseminated intravascular coagulation syndrome with local coagulopathy. (8504977)
1993
39
Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis. (3032668)
1987
40
An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue. (3478024)
1987
41
Oral submucous fibrosis: a cause for concern. (3459489)
1986
42
HLA-typing in oral submucous fibrosis. (3864289)
1985
43
Ultrastructural findings of muscle degeneration in oral submucous fibrosis. (3932624)
1985
44
Oral submucous fibrosis in a Greek female. (6945122)
1981
45
Focal vascular dilatations and petechiae in oral submucous fibrosis. (6947387)
1981
46
Oral submucous fibrosis. (6807916)
1981
47
Studies on oral submucous fibrosis. III. Epithelial changes. (1062749)
1976
48
Oral submucous fibrosis in Natal. (5284738)
1969
49
Prevalence of oral submucous fibrosis among 50,915 Indian villagers. (5705134)
1968
50
Histological features of oral submucous fibrosis. (5234089)
1967

Genetic Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 51QIAGEN
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Pathways related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CTLA4
210.3GSTT1, GSTM1
310.3GSTT1, GSTM1
410.3COL1A2, LOX
5
Hide members
10.3CYP1A1, CYP3A5
6
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.2MMP1, MMP3, TIMP1
7
Naphthalene metabolism
Hide members
10.2GSTT1, GSTM1, CYP1A1
8
Hide members
10.2MMP1, MMP8, MMP3, TIMP1
9
Hide members
10.2CYP1A1, CYP3A5, NAT2
10
Hide members
10.1COL1A2, TIMP1, MMP3, MMP8
11
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
12
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
13
Hide members
10.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
14
Cell adhesion ECM remodeling
Hide members
10.0MMP1, MMP8, MMP3, CST3, TIMP1, COL1A2

Compounds for genes affiliated with Oral Submucous Fibrosis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.8LOX
2procollagen4410.7COL1A2
3pge24410.6BIRC5
4(4-aminophenyl)mercuric acetate4410.6TIMP1, MMP3, MMP8
5drugs for treatment of tuberculosis4910.6GSTT1, GSTM1, NAT2
6alpha tocopherol4410.5CYP1A1, GSTM1
71-hydroxypyrene4410.5GSTM1, GSTT1, NAT2, CYP1A1
8hydroxamate4410.5TIMP1, MMP3, MMP8, MMP1
9sulfonamide4410.5GSTM1, MMP1, MMP3, NAT2
10benzene4410.5GSTT1, XRCC3, GSTM1, NAT2
11marimastat44 59 1112.4MMP1, MMP8, MMP3, TIMP1
12aflatoxin b144 2411.4CYP3A5, GSTM1, GSTT1, NAT2
13infliximab44 49 1112.4TIMP1, MMP1, MMP3, LTA, CTLA4
14rsai4410.4COL1A2, GSTM1, GSTT1, NAT2
15h2o24410.4LTA, CYP1A1, LOX, MMP1, MMP8
16mspi4410.4NAT2, CYP1A1, GSTT1, COL1A2, GSTM1
17hydrocarbons4410.4NAT2, CYP1A1, GSTM1, GSTT1
18folate4410.4TIMP1, XRCC3, CST3, NAT2, GSTM1, GSTT1
19alendronate44 49 1112.4MMP1, TIMP1, MMP3, MMP8
20curcumin4410.4LOX, BIRC5, CYP1A1, MMP1, MMP3, TIMP1
21cyclosporin a44 28 5912.3CST3, CTLA4, LTA, CYP3A5, MMP1, MMP8
22glycosaminoglycan4410.3LOX, MMP3, MMP8, TIMP1, MMP1
23vitamin a44 11 2412.3MMP1, BIRC5, LOR, NAT2, CYP1A1, CST3
24quinacrine44 1111.3LOX, CYP3A5, MMP3, MMP1
25mifepristone44 59 28 1113.3CYP3A5, MMP3, MMP1, BIRC5, TIMP1
26thalidomide44 49 59 1113.3BIRC5, NAT2, CYP3A5, CYP1A1, CTLA4
27p0034410.3GSTT1, GSTM1, LTA, CST3, XRCC3
28uva 14410.2MMP1, MMP3, TIMP1
29paraffin4410.2LOX, MMP3, KRT17, BIRC5, MMP1, LTA
30n acetylcysteine4410.2CST3, CYP1A1, MMP3, MMP1, BIRC5, XRCC3
31oxygen44 2411.2MMP8, CYP3A5, LOX, BIRC5, GSTM1, CYP1A1
32gsts4410.2GSTT1, GSTM1, CYP1A1, NAT2
33cisplatin44 49 59 1113.2BIRC5, GSTT1, LOX, XRCC3, GSTM1, CYP1A1
34p0024410.2TIMP1, CTLA4, CST3, MMP3, BIRC5, GSTM1
35methotrexate44 49 1112.2MMP1, NAT2, CST3, TIMP1, CTLA4, MMP3
36etanercept44 49 1112.1MMP1, MMP3, TIMP1, LTA
37troglitazone44 28 59 1113.1CYP1A1, CYP3A5, MMP1, BIRC5
38dexamethasone44 49 28 1113.1LOX, TIMP1, CTLA4, CYP1A1, CYP3A5, NAT2
39ascorbic acid44 2411.1GSTT1, LOX, GSTM1, CYP1A1, MMP3, MMP1
40vegf4410.1LTA, MMP1, MMP8, MMP3, TIMP1, BIRC5
41cholesterol44 28 11 2413.1MMP3, CTLA4, NAT2, LTA, BIRC5, LOR
42progesterone44 59 28 11 2414.1MMP8, BIRC5, MMP1, MMP3, NAT2, CYP3A5
43lactate4410.0MMP8, MMP1, MMP3, LOX, BIRC5, GSTM1
44oligonucleotide4410.0GSTT1, KRT17, BIRC5, MMP1, MMP8, NAT2
45cysteine4410.0MMP3, LOX, MMP8, COL1A2, TIMP1, CST3
46serine4410.0LTA, TTK, KRT17, CTLA4, TIMP1, COL1A2
47lipid449.9LOR, LOX, CST3, CTLA4, CYP3A5, LTA
48retinoic acid44 2410.9LTA, CYP3A5, CYP1A1, TIMP1, LOX, MMP8
49vitamin d449.9MMP3, LTA, GSTM1, COL1A2, CTLA4
50batimastat44 59 1111.9TIMP1, MMP3, MMP8, MMP1

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9COL1A2, TIMP1, CST3, MMP3, MMP8, MMP1
2extracellular spaceGO:0056159.5MMP8, LOX, COL1A2, CST3, LTA, MICA

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249310.1GSTT1, CYP1A1, LTA, LOX
2extracellular matrix disassemblyGO:02261710.1MMP1, MMP8, MMP3, TIMP1, COL1A2
3extracellular matrix organizationGO:03019810.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
4xenobiotic metabolic processGO:0068059.9CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
5collagen catabolic processGO:0305749.8COL1A2, MMP3, MMP8, MMP1

Products for genes affiliated with Oral Submucous Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Submucous Fibrosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet