MCID: ORL004
MIFTS: 56

Oral Submucous Fibrosis

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Submucous Fibrosis

MalaCards integrated aliases for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 12 72 49 55 51 41 14 69
Oral Submucosal Fibrosis, Including of Tongue 12 69
Osmf 49 55
Oral Cavity Submucous Fibrosis 12
Oral Submucosal Fibrosis 12

Characteristics:

Orphanet epidemiological data:

55
oral submucous fibrosis
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:5773
ICD10 32 K13.5
ICD9CM 34 528.8
MeSH 41 D009914
NCIt 46 C34866
SNOMED-CT 64 32883009
Orphanet 55 ORPHA357154
UMLS via Orphanet 70 C0029172
ICD10 via Orphanet 33 K13.5

Summaries for Oral Submucous Fibrosis

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 357154Disease definitionOral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cellcancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.Visit the Orphanet disease page for more resources. Last updated: 7/16/2013

MalaCards based summary : Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral leukoplakia and leukoplakia, and has symptoms including narrow mouth, abnormality of the oral cavity and trismus. An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Gastric cancer. The drugs Hyaluronic acid and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, premalignant (1% transformation risk)... more...

Related Diseases for Oral Submucous Fibrosis

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 oral leukoplakia 31.1 GSTM1 GSTT1
2 leukoplakia 31.0 CYP1A1 GSTM1 GSTT1
3 oral squamous cell carcinoma 30.6 CDH1 MMP2 PTGS2
4 squamous cell carcinoma 30.3 CDH1 CYP1A1 MMP2 PTGS2
5 oral cancer 29.4 CDH1 CYP1A1 GSTM1 GSTT1 MMP2 PTGS2
6 fibrosis of extraocular muscles, congenital, 1 11.2
7 leukoregulin 10.4 PTGS2 TGFB1
8 mucositis 10.4
9 hearing loss, noise-induced 10.4 GSTM1 GSTT1
10 sister chromatid exchange, frequency of 10.4 GSTM1 GSTT1
11 isolated cleft lip 10.4 GSTM1 GSTT1
12 fibromatosis, gingival, 1 10.3 MMP2 TGFB1
13 drug-induced hepatitis 10.3 GSTM1 GSTT1
14 adenomyosis 10.2 MMP2 PTGS2
15 toxic oil syndrome 10.2 CYP1A1 GSTM1
16 conjunctival nevus 10.2 MMP2 TIMP1
17 conjunctivochalasis 10.2 MMP2 TIMP1
18 oral cavity cancer 10.2 CYP1A1 GSTM1 GSTT1
19 polyarteritis nodosa, childhood-onset 10.1
20 sorsby fundus dystrophy 10.1 MMP2 TIMP1
21 nasal cavity squamous cell carcinoma 10.1 MMP2 TIMP1
22 hypertrophic scars 10.1 MMP2 TGFB1 TIMP1
23 urinary tract obstruction 10.1 CDH1 PTGS2 TGFB1
24 osteoarthritis 10.1 PTGS2 TGFB1 TIMP1
25 blood group, i system 10.1
26 aging 10.1
27 burns 10.1
28 pemphigus 10.1
29 gingival fibromatosis 10.1 MMP2 TGFB1 TIMP1
30 aortic aneurysm 10.1 LOX MMP2 TIMP1
31 diffuse gastric cancer 10.0 CDH1 GSTM1 GSTT1
32 larynx cancer 10.0 GSTM1 GSTT1 MMP2
33 pemphigus vulgaris, familial 10.0
34 pemphigus vulgaris 10.0
35 papilloma 10.0
36 gingivitis 10.0
37 burning mouth syndrome 10.0
38 keratoconus 10.0 LOX MMP2 TIMP1
39 gastrointestinal system cancer 9.9 CDH1 MMP2 PTGS2
40 gallbladder cancer 9.9 CDH1 MMP2 PTGS2
41 clopidogrel resistance 9.9 CYP1A1 PTGS2
42 microcystic meningioma 9.9 CDH1 MMP2 TIMP1
43 lung giant cell carcinoma 9.9 CDH1 MMP2 TIMP1
44 endometriosis 9.9 GSTM1 GSTT1 MMP2 PTGS2
45 shoulder impingement syndrome 9.8 FLNA PTGS2
46 masticatory muscles, hypertrophy of 9.8
47 myositis 9.8
48 body mass index quantitative trait locus 1 9.8
49 anxiety 9.8
50 muscle hypertrophy 9.8

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to Oral Submucous Fibrosis

Symptoms & Phenotypes for Oral Submucous Fibrosis

Human phenotypes related to Oral Submucous Fibrosis:

55 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 narrow mouth 55 31 hallmark (90%) Very frequent (99-80%) HP:0000160
2 abnormality of the oral cavity 55 31 hallmark (90%) Very frequent (99-80%) HP:0000163
3 trismus 55 31 frequent (33%) Frequent (79-30%) HP:0000211
4 abnormality of the pharynx 55 31 hallmark (90%) Very frequent (99-80%) HP:0000600
5 flexion contracture 55 31 frequent (33%) Frequent (79-30%) HP:0001371
6 oropharyngeal squamous cell carcinoma 55 31 occasional (7.5%) Occasional (29-5%) HP:0012182
7 cheilitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100825

UMLS symptoms related to Oral Submucous Fibrosis:


oral manifestations

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 PTGS2 CDH1 SFRP4 CYP1A1 TGFB1 FLNA
2 homeostasis/metabolism MP:0005376 9.96 PTGS2 CDH1 SFRP4 CYP1A1 DKK3 TGFB1
3 hematopoietic system MP:0005397 9.92 PTGS2 SFRP4 CYP1A1 DKK3 TGFB1 FLNA
4 immune system MP:0005387 9.81 PTGS2 CDH1 SFRP4 CYP1A1 DKK3 TGFB1
5 neoplasm MP:0002006 9.35 PTGS2 CDH1 TGFB1 TIMP1 MMP2
6 respiratory system MP:0005388 9.17 PTGS2 SFRP4 TGFB1 FLNA TIMP1 LOX

Drugs & Therapeutics for Oral Submucous Fibrosis

Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741 24759
2
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 657311 5754
3
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
4 Anti-Inflammatory Agents Phase 3,Phase 2
5 Adjuvants, Immunologic Phase 3
6 Cortisol succinate Phase 3
7 Viscosupplements Phase 3
8 Hydrocortisone 17-butyrate 21-propionate Phase 3
9 Hydrocortisone acetate Phase 3
10 Hydrocortisone-17-butyrate Phase 3
11 Protective Agents Phase 3
12 Antioxidants Phase 3
13
Curcumin Approved, Investigational Phase 2 458-37-7 969516
14
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
15
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
16
Tegafur Approved, Investigational Phase 2 17902-23-7 5386
17 tannic acid Approved, Nutraceutical Phase 2
18
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Peripheral Nervous System Agents Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 2
23 Antirheumatic Agents Phase 2
24 Antimetabolites Phase 2
25 Antimetabolites, Antineoplastic Phase 2
26 Astragalus Nutraceutical Phase 2
27 Immunoglobulins
28 Antibodies
29 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study Completed NCT02714543 Phase 3 aloevera juice;Hydrocortisone;Hyaluronic Acid;antioxidant;aloevera gel
2 Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF) Unknown status NCT02645656 Phase 2 Curcumin Arm
3 A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy Terminated NCT01720563 Phase 2 Astragalus polysaccharides 500 mg;Placebo
4 Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis Completed NCT03011086
5 Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis Completed NCT02711046

Search NIH Clinical Center for Oral Submucous Fibrosis

Cochrane evidence based reviews: oral submucous fibrosis

Genetic Tests for Oral Submucous Fibrosis

Anatomical Context for Oral Submucous Fibrosis

MalaCards organs/tissues related to Oral Submucous Fibrosis:

38
Tongue, Skin, Endothelial, T Cells, Testes, Salivary Gland, Liver

Publications for Oral Submucous Fibrosis

Articles related to Oral Submucous Fibrosis:

(show top 50) (show all 548)
# Title Authors Year
1
TFM classification and Staging of oral submucous fibrosis: A new proposal. ( 29405430 )
2018
2
Expression of I^1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma. ( 29113685 )
2018
3
Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint. ( 29422478 )
2018
4
New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment. ( 29428570 )
2018
5
Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry. ( 28826108 )
2018
6
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail. ( 29328529 )
2018
7
Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population. ( 29391727 )
2017
8
Breath Alkane as an index of severity for oral submucous fibrosis: A new perspective? ( 28012596 )
2017
9
A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients. ( 29223311 )
2017
10
An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis. ( 28862199 )
2017
11
Velar morphological variants in oral submucous fibrosis: A comparative digital cephalometric study. ( 29256459 )
2017
12
Evaluation of Oral Pentoxifylline in the Management of Oral Submucous Fibrosis - An Ultrasonographic Study. ( 28839403 )
2017
13
Correlation of ultrasonographic measurements, histopathological grading, and clinical staging in oral submucous fibrosis. ( 29072206 )
2017
14
Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis By Epigenetically Reactivating the p53 Pathway. ( 28550687 )
2017
15
PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix. ( 29088825 )
2017
16
LncRNA GAS5-AS1 inhibits myofibroblasts activities in oral submucous fibrosis. ( 29249416 )
2017
17
Oral submucous fibrosis: an etiological dilemma. ( 29161786 )
2017
18
STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis. ( 29210111 )
2017
19
Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis. ( 29207828 )
2017
20
Developing a quality-of-life questionnaire for oral submucous fibrosis patients. ( 28865104 )
2017
21
Evaluation of myofibroblasts in oral submucous fibrosis and oral squamous cell carcinoma: The pathogenesis and correlation. ( 29109745 )
2017
22
Total Serum Protein Estimation and Its Correlation with Clinical and Histopathological Grading using Masson's Trichrome Stain in Patients of Oral Submucous Fibrosis. ( 28839417 )
2017
23
Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitorA 3, in the malignant progression of oral submucous fibrosis. ( 27959428 )
2017
24
Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis. ( 28761276 )
2017
25
Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without. ( 28606826 )
2017
26
Identification of I+-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis. ( 28821582 )
2017
27
Thioctic acid in oral submucous fibrosis (India's disease) - A better tomorrow. ( 29246754 )
2017
28
Identification of over expressed proteins in Oral Submucous Fibrosis by proteomic analysis. ( 28980718 )
2017
29
Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: A meta-analysis. ( 28737007 )
2017
30
Oral submucous fibrosis in a school-going Indian adolescent boy. ( 28731854 )
2017
31
Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies. ( 29386809 )
2017
32
Comparative Evaluation of Serum Lipid Profile in Patients with Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with that of Control Subjects: A Case Control Study. ( 29284962 )
2017
33
Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging. ( 28479685 )
2017
34
Oral submucous fibrosis: An update. ( 29391702 )
2017
35
Effectiveness of Osteopathic Therapy in the Treatment of Oral Submucous Fibrosis. ( 28566867 )
2017
36
Prosthetic rehabilitation of oral submucous fibrosis patients: A systematic review of published case reports and case series. ( 28877246 )
2017
37
Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood. ( 28483252 )
2017
38
Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study. ( 28717289 )
2017
39
Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis. ( 28826174 )
2017
40
Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages. ( 28658917 )
2017
41
Assessment of anxiety, depression, and serum cortisol level in oral submucous fibrosis patients: A controlled clinical trial. ( 28932136 )
2017
42
Oral submucous fibrosis-an increasing global healthcare problem. ( 28672092 )
2017
43
Effect of curcumin on the expression of p53, transforming growth factor-I^, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study. ( 27989010 )
2016
44
Comment on "Facial Atrophy in Oral Submucous Fibrosis: An Association or a Coincidence". ( 27891262 )
2016
45
Is there an association between oral submucous fibrosis and ABO blood grouping? ( 27072224 )
2016
46
Myofibroblasts could be recruited in a Chemokine (C-C motif) Ligand 2-dependant manner in pathogenesis of oral submucous fibrosis. ( 28029690 )
2016
47
Assessment of Function of Eustachian Tube in Oral Submucous Fibrosis - A Tympanometric Study. ( 27790571 )
2016
48
A Rare Case of Tamarind Seed Induced Oral Submucous Fibrosis in a 12-Year-Old Indian Boy. ( 27504424 )
2016
49
High risk of malignant transformation of oral submucous fibrosis in Pakistani females: A potential national disaster. ( 27812049 )
2016
50
Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis. ( 26088962 )
2016

Variations for Oral Submucous Fibrosis

Expression for Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for Oral Submucous Fibrosis

Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 CYP1A1 GSTM1 GSTT1 PTGS2
2
Show member pathways
12.49 CDH1 GSTM1 GSTT1 TGFB1
3
Show member pathways
12.42 CDH1 LOX MMP2 TGFB1 TIMP1
4 12.16 CDH1 GSTM1 GSTT1 MMP2 PTGS2 TGFB1
5 11.84 CDH1 MMP2 PTGS2 TGFB1
6 11.83 GSTM1 GSTT1 MMP2
7 11.81 FLNA MMP2 TGFB1
8 11.61 MMP2 PTGS2 TGFB1 TIMP1
9
Show member pathways
11.51 CYP1A1 GSTM1 GSTT1
10 11.38 MMP2 TGFB1 TIMP1
11 11.02 GSTM1 GSTT1
12 10.87 MMP2 PTGS2 TGFB1 TIMP1
13 10.75 DKK3 SFRP4
14 10.73 CDH1 TGFB1
15 10.71 CYP1A1 GSTM1 GSTT1
16 10.63 GSTT1 PTGS2

GO Terms for Oral Submucous Fibrosis

Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CDH1 FLNA LOX MMP2 SFRP4 TGFB1
2 extracellular matrix GO:0031012 9.26 FLNA MMP2 TGFB1 TIMP1
3 proteinaceous extracellular matrix GO:0005578 8.92 LOX MMP2 TGFB1 TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.74 CYP1A1 MMP2 TGFB1
2 response to organic cyclic compound GO:0014070 9.67 CYP1A1 PTGS2 TGFB1
3 platelet degranulation GO:0002576 9.65 FLNA TGFB1 TIMP1
4 face morphogenesis GO:0060325 9.58 MMP2 TGFB1
5 positive regulation of vascular endothelial growth factor production GO:0010575 9.58 PTGS2 TGFB1
6 response to immobilization stress GO:0035902 9.56 CYP1A1 TGFB1
7 glutathione derivative biosynthetic process GO:1901687 9.55 GSTM1 GSTT1
8 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.54 DKK3 TGFB1
9 wound healing GO:0042060 9.54 LOX TGFB1 TIMP1
10 response to vitamin D GO:0033280 9.52 PTGS2 TGFB1
11 positive regulation of protein import into nucleus GO:0042307 9.51 PTGS2 TGFB1
12 extracellular matrix disassembly GO:0022617 9.5 CDH1 MMP2 TIMP1
13 positive regulation of transcription factor import into nucleus GO:0042993 9.46 CDH1 FLNA
14 aging GO:0007568 9.46 CYP1A1 PTGS2 TGFB1 TIMP1
15 cell activation GO:0001775 9.43 TGFB1 TIMP1
16 response to hormone GO:0009725 9.43 LOX SFRP4 TIMP1
17 negative regulation of cell-cell adhesion GO:0022408 9.4 CDH1 TGFB1
18 response to drug GO:0042493 9.35 CDH1 CYP1A1 LOX PTGS2 TGFB1
19 response to organic substance GO:0010033 9.02 CDH1 CYP1A1 PTGS2 TGFB1 TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 CYP1A1 GSTM1 PTGS2 TGFB1

Sources for Oral Submucous Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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