OSMF
MCID: ORL004
MIFTS: 51

Oral Submucous Fibrosis (OSMF) malady

Gastrointestinal, Oral categories

Summaries for Oral Submucous Fibrosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition... more...

MalaCards: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to leukoplakia and squamous cell carcinoma, and has symptoms including contractures/cramps/trismus/tetania/claudication/opisthotonos, oral mucosa disease/cheilitis and anomalies of tongue, gingiva and oral mucosa. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Rheumatoid arthritis and Aflatoxin B1 metabolism. The compounds indomethacin and procollagen have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Oral


Characteristics (Orphanet epidemiological data):

49
oral submucous fibrosis:
Age of onset: Variable


Aliases & Descriptions:

oral submucous fibrosis 8 43 10 45 49 61
oral submucosal fibrosis, including of tongue 8 61
oral cavity submucous fibrosis 8
oral submucosal fibrosis 8
osmf 49


External Ids:

Disease Ontology8 DOID:5773
ICD9CM27 528.8
NCIt40 C34866
SNOMED-CT57 32883009
ICD10 via Orphanet26 K13.5
ICD1025 K13.5

Related Diseases for Oral Submucous Fibrosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1leukoplakia31.2GSTT1, GSTM1, CYP1A1
2squamous cell carcinoma31.2CYP1A1, CTLA4, CST3, XRCC3, TIMP1, LOX
3oral cancer31.1CYP1A1, MMP1, BIRC5, GSTM1, GSTT1
4adenoma30.3LOX, XRCC3, CTLA4, CYP1A1, CYP3A5, NAT2
5oral leukoplakia10.8
6oral squamous cell carcinoma10.8
7verrucous carcinoma10.5
8squamous cell papilloma10.4
9burning mouth syndrome10.4
10pemphigus10.4
11ankylosis10.2
12cellulitis10.2
13oral mucosa leukoplakia10.2
14anal squamous cell carcinoma10.2
15temporomandibular ankylosis10.2
16pemphigus vulgaris10.2
17hypertension10.0CST3
18basal cell carcinoma10.0KRT17
19keratosis10.0LOR
20thyroiditis10.0CTLA4
21cerebral palsy10.0MMP8
22lupus erythematosus10.0NAT2
23malignant mesothelioma10.0NAT2
24essential hypertension10.0CST3
25colon adenocarcinoma10.0LOX
26migraine10.0GSTM1
27dilated cardiomyopathy10.0MMP1
28tuberculosis10.0NAT2
29peritonitis10.0MMP8
30bronchiolitis obliterans10.0MMP8
31primary hyperoxaluria10.0CST3
32ehlers-danlos syndrome10.0COL1A2
33myocardial infarction10.0GSTT1, CST3
34connective tissue disease10.0CTLA4
35polycythemia vera10.0TIMP1
36cleft palate10.0GSTM1
37skin cancer10.0CYP1A1, XRCC3
38malaria10.0GSTM1
39vitiligo10.0CTLA4
40thyroid cancer10.0GSTM1, GSTT1
41malignant glioma10.0BIRC5
42cleft lip10.0GSTM1
43cerebrovascular disease10.0CST3
44dermatitis10.0CTLA4, LOR
45bladder carcinoma10.0LTA
46primary open angle glaucoma10.0GSTM1
47polycythemia10.0TIMP1
48sarcoidosis10.0LTA
49schistosomiasis10.0GSTM1
50sarcoma10.0GSTM1, LOX

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Clinical Features for Oral Submucous Fibrosis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 6)
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • limited opening of the mouth

Drugs & Therapeutics for Oral Submucous Fibrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Submucous Fibrosis

Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Search CenterWatch for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

Anatomical Context for Oral Submucous Fibrosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Oral Submucous Fibrosis:

33
Skin, Liver, Tongue, Salivary gland, T cells, B cells, Endothelial

Animal Models for Oral Submucous Fibrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9GSTT1, NAT2, LTA, CTLA4, CST3, LOX

Publications for Oral Submucous Fibrosis

Sources:
51PubMed
See all sources

Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 386)
idTitleAuthorsYear
1
Evaluation of the possible role of copper ions in drinking water in the pathogenesis of oral submucous fibrosis: a pilot study. (23434268)
2014
2
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
3
Pathogenesis and therapeutic intervention of oral submucous fibrosis. (23946584)
2013
4
Tripaddled anterolateral thigh flap for simultaneous reconstruction of bilateral buccal defects after buccal cancer ablation and severe oral submucous fibrosis release: A case report. (23922263)
2013
5
Dentoalveolar Surgery in Oral Submucous Fibrosis: Need for Caution. (24431865)
2013
6
The use of buccal fat pad in the treatment of oral submucous fibrosis: a newer method. (22666254)
2012
7
Oral submucous fibrosis: a report of two pediatric cases and a brief review. (22565524)
2012
8
Comment on Mukherjee S et al. "Zinc and Vitamin A as a low cost management of oral submucous fibrosis". (22902123)
2012
9
Zinc and vitamin A as a low cost management of oral submucous fibrosis: comment on Chole RH et al. "Review of drug treatment of oral submucous fibrosis. Oral Oncol 2012; 48(5):393-398". (22705357)
2012
10
Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis. (21467820)
2011
11
Matrix metalloproteinase-1 expression in oral submucous fibrosis: an immunohistochemical study. (20930336)
2010
12
Management of oral submucous fibrosis: an overview. (20177949)
2010
13
Gutka syndrome and oral submucous fibrosis: few observations. (21131765)
2010
14
Diagnosis of oral submucous fibrosis with optical coherence tomography. (19895110)
2009
15
Oral submucous fibrosis and restricted mouth opening. (18821902)
2008
16
Gene expression profiling of oral submucous fibrosis using oligonucleotide microarray. (18636188)
2008
17
Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts. (16996785)
2007
18
Development of an in vivo mouse model to study oral submucous fibrosis. (17448137)
2007
19
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
20
The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users. (16430740)
2006
21
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
22
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
23
HLA typing in Taiwanese patients with oral submucous fibrosis. (15061705)
2004
24
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. (12907213)
2003
25
Morphohistometric analysis of advancing tumor fronts in malignancies associated with oral submucous fibrosis. (15328984)
2003
26
Total oral reconstruction for cancers associated with advanced oral submucous fibrosis. (12966241)
2003
27
Association between genetic polymorphism of tumor necrosis factor-alpha and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer. (11808761)
2001
28
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
29
Oral submucous fibrosis patients have altered levels of cytokine production. (10738939)
2000
30
Snoring and oral submucous fibrosis. (9176616)
1997
31
Tobacco chewing, oral submucous fibrosis, and anaesthetic risk. (8667958)
1996
32
Zinc and iron as bioindicators of precancerous nature of oral submucous fibrosis. (8909695)
1996
33
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
34
Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases. (8537913)
1995
35
Oral submucous fibrosis: etiology, pathogenesis, and future research. (7867145)
1994
36
Oral submucous fibrosis. (7950926)
1993
37
Oral submucous fibrosis in a 12-year-old girl: case report. (8327363)
1993
38
Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer. (1544110)
1992
39
Oral submucous fibrosis. Case report and review of the literature. (1567291)
1992
40
Serum levels of iron and proteins in oral submucous fibrosis (OSMF). (2278476)
1990
41
Histomorphology of oral submucous fibrosis. Report of 24 cases. (3147848)
1988
42
Concomitant occurrence of oral submucous fibrosis, pemphigus and squamous cell carcinoma. (3229809)
1988
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
SCE frequencies in lymphocytes of tobacco/betel nut chewers and patients with oral submucous fibrosis. (3947511)
1986
45
Malignant transformation rate in oral submucous fibrosis over a 17-year period. (3866655)
1985
46
Estimation of major immunoglobulin profile in oral submucous fibrosis by radial immunodiffusion. (3936802)
1985
47
Oral submucous fibrosis--treatment with hyalase. (3968475)
1985
48
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
49
EPITHELIAL CHANGES IN ORAL SUBMUCOUS FIBROSIS. (14321742)
1965
50
CLINICAL ASPECTS OF ORAL SUBMUCOUS FIBROSIS. (14280849)
1964

Genetic Variations for Oral Submucous Fibrosis

Expression for genes affiliated with Oral Submucous Fibrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

Sources:
30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CTLA4
210.3GSTT1, GSTM1
310.3GSTT1, GSTM1
410.3COL1A2, LOX
5
Hide members
10.3CYP1A1, CYP3A5
6
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.2MMP1, MMP3, TIMP1
7
Naphthalene metabolism
Hide members
10.2GSTT1, GSTM1, CYP1A1
8
Hide members
10.2MMP1, MMP8, MMP3, TIMP1
9
Hide members
10.2CYP1A1, CYP3A5, NAT2
10
Hide members
10.1COL1A2, TIMP1, MMP3, MMP8
11
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
12
Hide members
10.0CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
13
Hide members
10.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
14
Cell adhesion ECM remodeling
Hide members
10.0MMP1, MMP8, MMP3, CST3, TIMP1, COL1A2

Compounds for genes affiliated with Oral Submucous Fibrosis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1indomethacin45 60 29 1113.8LOX
2procollagen4510.7COL1A2
3pge24510.6BIRC5
4(4-aminophenyl)mercuric acetate4510.6TIMP1, MMP3, MMP8
5drugs for treatment of tuberculosis5010.6GSTT1, GSTM1, NAT2
6alpha tocopherol4510.5CYP1A1, GSTM1
71-hydroxypyrene4510.5GSTM1, GSTT1, NAT2, CYP1A1
8hydroxamate4510.5TIMP1, MMP3, MMP8, MMP1
9sulfonamide4510.5GSTM1, MMP1, MMP3, NAT2
10benzene4510.5GSTT1, XRCC3, GSTM1, NAT2
11marimastat45 60 1112.4MMP1, MMP8, MMP3, TIMP1
12aflatoxin b145 2411.4CYP3A5, GSTM1, GSTT1, NAT2
13infliximab45 50 1112.4TIMP1, MMP1, MMP3, LTA, CTLA4
14rsai4510.4COL1A2, GSTM1, GSTT1, NAT2
15h2o24510.4LTA, CYP1A1, LOX, MMP1, MMP8
16mspi4510.4NAT2, CYP1A1, GSTT1, COL1A2, GSTM1
17hydrocarbons4510.4NAT2, CYP1A1, GSTM1, GSTT1
18folate4510.4TIMP1, XRCC3, CST3, NAT2, GSTM1, GSTT1
19alendronate45 50 1112.4MMP1, TIMP1, MMP3, MMP8
20curcumin4510.4LOX, BIRC5, CYP1A1, MMP1, MMP3, TIMP1
21cyclosporin a45 29 6012.3CST3, CTLA4, LTA, CYP3A5, MMP1, MMP8
22glycosaminoglycan4510.3LOX, MMP3, MMP8, TIMP1, MMP1
23vitamin a45 11 2412.3MMP1, BIRC5, LOR, NAT2, CYP1A1, CST3
24quinacrine45 1111.3LOX, CYP3A5, MMP3, MMP1
25mifepristone45 60 29 1113.3CYP3A5, MMP3, MMP1, BIRC5, TIMP1
26thalidomide45 50 60 1113.3BIRC5, NAT2, CYP3A5, CYP1A1, CTLA4
27p0034510.3GSTT1, GSTM1, LTA, CST3, XRCC3
28uva 14510.2MMP1, MMP3, TIMP1
29paraffin4510.2LOX, MMP3, KRT17, BIRC5, MMP1, LTA
30n acetylcysteine4510.2CST3, CYP1A1, MMP3, MMP1, BIRC5, XRCC3
31oxygen45 2411.2MMP8, CYP3A5, LOX, BIRC5, GSTM1, CYP1A1
32gsts4510.2GSTT1, GSTM1, CYP1A1, NAT2
33cisplatin45 50 60 1113.2BIRC5, GSTT1, LOX, XRCC3, GSTM1, CYP1A1
34p0024510.2TIMP1, CTLA4, CST3, MMP3, BIRC5, GSTM1
35methotrexate45 50 1112.2MMP1, NAT2, CST3, TIMP1, CTLA4, MMP3
36etanercept45 50 1112.1MMP1, MMP3, TIMP1, LTA
37troglitazone45 29 60 1113.1CYP1A1, CYP3A5, MMP1, BIRC5
38dexamethasone45 50 29 1113.1LOX, TIMP1, CTLA4, CYP1A1, CYP3A5, NAT2
39ascorbic acid45 2411.1GSTT1, LOX, GSTM1, CYP1A1, MMP3, MMP1
40vegf4510.1LTA, MMP1, MMP8, MMP3, TIMP1, BIRC5
41cholesterol45 29 11 2413.1MMP3, CTLA4, NAT2, LTA, BIRC5, LOR
42progesterone45 60 29 11 2414.1MMP8, BIRC5, MMP1, MMP3, NAT2, CYP3A5
43lactate4510.0MMP8, MMP1, MMP3, LOX, BIRC5, GSTM1
44oligonucleotide4510.0GSTT1, KRT17, BIRC5, MMP1, MMP8, NAT2
45cysteine4510.0MMP3, LOX, MMP8, COL1A2, TIMP1, CST3
46serine4510.0LTA, TTK, KRT17, CTLA4, TIMP1, COL1A2
47lipid459.9LOR, LOX, CST3, CTLA4, CYP3A5, LTA
48retinoic acid45 2410.9LTA, CYP3A5, CYP1A1, TIMP1, LOX, MMP8
49vitamin d459.9MMP3, LTA, GSTM1, COL1A2, CTLA4
50batimastat45 60 1111.9TIMP1, MMP3, MMP8, MMP1

GO Terms for genes affiliated with Oral Submucous Fibrosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9COL1A2, TIMP1, CST3, MMP3, MMP8, MMP1
2extracellular spaceGO:0056159.5MMP8, LOX, COL1A2, CST3, LTA, MICA

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249310.1GSTT1, CYP1A1, LTA, LOX
2extracellular matrix disassemblyGO:02261710.1MMP1, MMP8, MMP3, TIMP1, COL1A2
3extracellular matrix organizationGO:03019810.0LOX, COL1A2, TIMP1, MMP3, MMP8, MMP1
4xenobiotic metabolic processGO:0068059.9CYP1A1, CYP3A5, NAT2, GSTM1, GSTT1
5collagen catabolic processGO:0305749.8COL1A2, MMP3, MMP8, MMP1

Products for genes affiliated with Oral Submucous Fibrosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Submucous Fibrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet