MCID: ORL004
MIFTS: 55

Oral Submucous Fibrosis malady

Rare diseases, Gastrointestinal diseases, Oral diseases categories

Summaries for Oral Submucous Fibrosis

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Wikipedia:65 Oral submucous fibrosis (OSMF) is a chronic, complex potential potent pre-cancerous ( appox 20% may have... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral cancer and gingivitis, and has symptoms including abnormality of the oral cavity, trismus and abnormality of the pharynx. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Matrix Metalloproteinases. The compounds uva 1 and latanoprost have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and liver, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 57SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 27ICD10
See all sources

Oral Submucous Fibrosis, Aliases & Descriptions:

Name: Oral Submucous Fibrosis 10 43 12 45 49 62
Oral Submucosal Fibrosis, Including of Tongue 10 62
Oral Submucosal Fibrosis 10 62
 
Oral Cavity Submucous Fibrosis 10
Osmf 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

49
oral submucous fibrosis:
Age of onset: All ages


External Ids:

Disease Ontology10 DOID:5773
NCIt40 C34866
ICD9CM29 528.8
SNOMED-CT57 32883009
Orphanet49 357154
ICD10 via Orphanet28 K13.5
ICD1027 K13.5

Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.0GSTT1, MMP1
2gingivitis30.5TIMP1, MMP8, MMP1, CST3
3periodontitis30.4MMP8
4leukoplakia10.8
5oral squamous cell carcinoma10.8
6oral leukoplakia10.7
7burns10.5
8pemphigus10.5
9pemphigus vulgaris10.4
10burning mouth syndrome10.4
11verrucous carcinoma10.4
12papilloma10.4
13muscle hypertrophy10.2
14adenomatous polyposis coli10.2
15ankylosis10.2
16cellulitis10.2
17disseminated intravascular coagulation10.2
18laryngitis10.2
19lipodystrophy10.2
20endotheliitis10.2
21localized scleroderma10.0LOX, MMP1
22conjunctivochalasis10.0MMP1, TIMP1
23pulpitis10.0TIMP1, MMP1
24hypertrophic scars10.0TIMP1, MMP1
25aggressive periodontitis10.0MMP1, MMP8
26pulmonary emphysema10.0MMP1, MMP8
27open-angle glaucoma10.0GSTT1, MMP1
28arthropathy10.0TIMP1, MMP1
29gingival overgrowth10.0LOX, MMP1, TIMP1
30pulmonary fibrosis10.0TIMP1, MMP1, LOX
31systemic scleroderma10.0LOX, MMP1, TIMP1
32laryngeal squamous cell carcinoma10.0MMP1, GSTT1
33pulmonary fibrosis, idiopathic10.0MMP1, TIMP1
34keloids10.0LOX, MMP1, MMP8
35keratoconus10.0MMP1, MMP8, TIMP1
36skin disease10.0MMP1, LOX, LOR
37synovitis10.0TIMP1, MMP8, MMP1
38ovarian cancer, somatic10.0GSTT1, LOX, TIMP1
39periodontal disease10.0MMP1, MMP8, TIMP1
40endometriosis10.0TIMP1, MMP1, GSTT1
41osteosarcoma, somatic10.0LOX, MMP1, TIMP1
42nicotine dependence, protection against10.0GSTT1, XRCC3
43osteoarthritis10.0MMP1, MMP8, TIMP1
44xeroderma pigmentosum, variant type10.0XRCC3, GSTT1
45arthritis10.0TIMP1, MMP8, MMP1
46basal cell carcinoma10.0GSTT1, XRCC3, MMP1
47congenital heart disease10.0CST3, MMP1, TIMP1
48squamous cell carcinoma, head and neck10.0TIMP1, MMP1, LOX, GSTT1
49fibrosarcoma10.0CST3, MMP1, TIMP1
50aneurysm10.0CST3, LOX, MMP8

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Symptoms:

 49
  • limited opening of the mouth
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oropharyngeal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

33
Tongue, Skin, Liver, Salivary gland, Testes, T cells, Endothelial

Animal Models for Oral Submucous Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CST3, MMP1, MMP8, TIMP1
2MP:00053767.2GSTT1, TIMP1, MMP1, LOX, LOR, CST3

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
2
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
3
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
4
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
5
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
6
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
7
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
8
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
9
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
10
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
11
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
12
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
13
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
14
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
15
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
16
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
17
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
18
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
19
Oral submucous fibrosis in a young patient. (20043056)
2009
20
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
21
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
22
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
23
Interventions for the management of oral submucous fibrosis. (18843745)
2008
24
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
25
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
26
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
27
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
28
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
29
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
30
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
31
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
32
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
33
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
34
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
35
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
36
Raised tissue copper levels in oral submucous fibrosis. (10890553)
2000
37
Oral submucous fibrosis in paediatric age group. (23119548)
1999
38
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
39
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
40
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
41
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
42
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
Oral submucous fibrosis. (3864703)
1985
45
HLA-typing in oral submucous fibrosis. (3864289)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Compounds for genes affiliated with Oral Submucous Fibrosis

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Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1uva 14510.1MMP1, TIMP1
2latanoprost45 1311.0MMP1, TIMP1
3grgdsp4510.0TIMP1, MMP1
4nimesulide45 1311.0TIMP1, MMP1
5u01264510.0MMP1, TIMP1
6lutein459.9TIMP1, MMP1
7hocl459.9TIMP1, MMP8
8clodronate45 51 1311.8MMP8, MMP1
9hydroxyproline45 26 1311.8LOX, MMP1, TIMP1
10kt 572045 61 3011.8MMP1, TIMP1
11pyridinoline459.8TIMP1, LOX
12procollagen459.7LOX, MMP1, TIMP1
13alpha tocopherol459.7LOX, MMP1, TIMP1
14uk 383367619.7MMP8, MMP1
15gi 254023x619.7MMP8, MMP1
16carbon459.7LOX, MMP1, TIMP1
17curcumin459.7LOX, MMP1, TIMP1
18gm 6001619.7MMP8, MMP1
19prostaglandin459.7TIMP1, MMP1, LOX
20(4-aminophenyl)mercuric acetate459.6TIMP1, MMP8, MMP1
21hydroxamate459.6MMP1, MMP8, TIMP1
22marimastat45 61 1311.6TIMP1, MMP8, MMP1
23aspirin45 51 30 2612.6LOX, MMP1, TIMP1
24alendronate45 51 1311.6MMP1, MMP8, TIMP1
25batimastat45 61 1311.6TIMP1, MMP8, MMP1
26doxycycline45 1310.6TIMP1, MMP8, MMP1
27indomethacin45 30 61 1312.3LOX, MMP1, TIMP1
28glycosaminoglycan459.3TIMP1, MMP8, MMP1, LOX
29aprotinin45 1310.3TIMP1, MMP1, CST3
30benzene459.2GSTT1, XRCC3
31pge2459.2TIMP1, MMP8, MMP1, LOX
32h2o2459.2TIMP1, MMP8, MMP1, LOX
33urea45 26 1311.1MMP8, LOX, CST3
34methotrexate51 45 1311.1CST3, MMP1, TIMP1
35matrigel458.9TIMP1, MMP1, LOX, CST3
36ascorbic acid45 269.9GSTT1, LOX, MMP1
37p003458.9XRCC3, CST3, GSTT1
38vitamin a45 26 1310.8TIMP1, MMP1, LOR, CST3
39dexamethasone45 51 30 1311.8CST3, LOX, MMP1, TIMP1
40retinoic acid45 269.8LOR, LOX, MMP1, MMP8, TIMP1
41cyclosporin a45 30 6110.7TIMP1, MMP8, MMP1, CST3
42p002458.7GSTT1, CST3, MMP8, TIMP1
43folate458.6TIMP1, XRCC3, CST3, GSTT1
44lactate458.4TIMP1, MMP8, MMP1, LOX, CST3
45vegf458.4TIMP1, MMP8, MMP1, LOX, CST3
46cysteine458.4TIMP1, MMP8, MMP1, LOX, CST3
47n acetylcysteine458.4CST3, XRCC3, LOX, MMP1, TIMP1
48cisplatin45 51 61 1311.2GSTT1, CST3, XRCC3, LOX, TIMP1
49serine458.2TIMP1, MMP8, MMP1, LOR, CST3
50lipid458.2GSTT1, CST3, LOR, LOX, MMP8

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.0CST3, LOX, MMP1, MMP8, TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endopeptidase activityGO:00109519.3CST3, TIMP1
2collagen catabolic processGO:00305749.2MMP1, MMP8
3extracellular matrix disassemblyGO:00226179.1TIMP1, MMP8, MMP1
4extracellular matrix organizationGO:00301988.8LOX, MMP1, MMP8, TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.3CST3, TIMP1

Products for genes affiliated with Oral Submucous Fibrosis

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Sources for Oral Submucous Fibrosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet