MCID: ORL004
MIFTS: 54

Oral Submucous Fibrosis malady

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Submucous Fibrosis

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 27ICD10, 29ICD9CM, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 10 45 47 12 51 65
Oral Submucosal Fibrosis, Including of Tongue 10 65
Osmf 45 51
 
Oral Cavity Submucous Fibrosis 10
Oral Submucosal Fibrosis 10

Characteristics:

Orphanet epidemiological data:

51
oral submucous fibrosis:
Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:5773
ICD1027 K13.5
ICD9CM29 528.8
MeSH36 D009914
SNOMED-CT59 32883009
NCIt42 C34866
Orphanet51 357154
ICD10 via Orphanet28 K13.5
UMLS65 C0029171, C0029172

Summaries for Oral Submucous Fibrosis

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Wikipedia:68 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, rarely will it turn ( 1% ) to a... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral leukoplakia and leukoplakia, and has symptoms including abnormality of the oral cavity, trismus and abnormality of the pharynx. An important gene associated with Oral Submucous Fibrosis is LOX (Lysyl Oxidase), and among its related pathways are Syndecan-2-mediated signaling events and Etoposide Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include tongue, breast and prostate, and related mouse phenotypes are respiratory system and tumorigenesis.

Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1oral leukoplakia28.6CDH1, CYP1A1, GSTM1, GSTT1, MMP2, PTGS2
2leukoplakia10.5
3filamentary keratitis10.5GSTM1, GSTT1
4nephronophthisis familial adult spastic quadriparesis10.5TGFB1, TIMP1
5ectodermal dysplasia10.5GSTM1, GSTT1
6oral squamous cell carcinoma10.4
7cystic echinococcosis10.4TGFB1, TIMP1
8baritosis10.4GSTM1, GSTT1
9noma10.4GSTM1, GSTT1
10mutiple parosteal osteochondromatous proliferations10.4GSTM1, GSTT1
11scleromalacia perforans10.4GSTM1, GSTT1
12oral cancer10.4
13humeroradial synostosis10.3MMP2, TGFB1
14mixed extragonadal germ cell cancer10.3MMP2, TIMP1
15gastric squamous cell carcinoma10.3MMP2, TIMP1
16gastrointestinal carcinoma10.3MMP2, TIMP1
17collagen vi-related myopathy10.3CYP1A1, PTGS2
18corneal dystrophy10.2MMP2, TIMP1
19gonadal dysgenesis10.2TGFB1, TIMP1
20osteochondritis dissecans10.2PTGS2, TGFB1, TIMP1
21oral candidiasis10.1CDH1, TGFB1
22laryngeal tuberculosis10.1COL1A1, TGFB1
23burns10.1
24verrucous carcinoma10.1
25pemphigus10.1
26ichthyosis with confetti10.1COL1A1, TGFB1
27levator syndrome10.1CYP1A1, GSTM1, GSTT1
28biliary tract neoplasm10.1CDH1, PTGS2
29juxtacortical chondroma10.0GSTM1, GSTT1, MMP2
30adenosarcoma of the uterus10.0MMP2, PTGS2, TIMP1
31pemphigus vulgaris10.0
32papilloma10.0
33gingivitis10.0
34burning mouth syndrome10.0
35exocervical carcinoma10.0GSTM1, MMP2, PTGS2
36malignant struma ovarii10.0CDH1, PTGS2, TGFB1
37localized osteosarcoma10.0MMP2, TGFB1, TIMP1
38lymphedema10.0MMP2, TGFB1, TIMP1
39diffuse idiopathic pulmonary neuroendocrine cell hyperplasia10.0CDH1, GSTM1, GSTT1
40pasteurellosis9.9CDH1, GSTM1, PTGS2
41molluscum contagiosum9.9MMP2, PTGS2
42dicrocoeliasis9.9COL1A1, TGFB1
43night blindness, congenital stationary , 1d, autosomal recessive9.9GSTM1, GSTT1
44muscle hypertrophy9.9
45adenomatous polyposis coli9.9
46deficiency anemia9.9
47disseminated intravascular coagulation9.9
48iron deficiency anemia9.9
49ankylosis9.9
50laryngitis9.9

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Symptoms:

 51
  • limited opening of the mouth
  • oral mucosa disease/cheilitis
  • anomalies of tongue, gingiva and oral mucosa
  • anomaly of the pharynx/pharyngeal anomaly
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • oropharyngeal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

UMLS symptoms related to Oral Submucous Fibrosis:


oral mucosa atrophy, pigmentation lip, chapping of lips, oral manifestations

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
HydrocortisoneapprovedPhase 358350-23-75754, 657311
Synonyms:
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
1 Hydrocortisone maximum strength
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11╬▓-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
999 Itch Relieving
A-hydrocort
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Advanced Hydrocortisone
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti Itch
Anti Itch maximum strength
Anti Itch maximum strength plus
Anti-inflammatory hormone
Anti-itch
Anti-itch Scalp Relief Maximum Strength
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Apres Peel Soothing Balm
Aquacort
Aquanil HC
Atopalm Maximum Strength Anti-itch
Atopalm Moisturizing Hydrocortisone
Aveeno Hydrocortisone Anti Itch
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
Bioelements Immediate Comfort Hydrocortisone
Budpak Anti-itch
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Caldecort
Care One Hydrocortisone maximum strength
Cetacort
Chronocort
Cicatricure Ultra Moisturizing
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortaid 12-hour Advanced Anti-Itch
Cortaid Intensive Therapy Cooling
Cortaid Maximum Strength
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisone
Cortisone Cream Intensive Healing
Cortisone Maximum Strength
Cortisone maximum strength
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortizone 10
Cortizone 10 Cooling Cream Anti-itch
Cortizone 10 Cooling Relief
Cortizone 10 Easy Relief
Cortizone 10 Hydratensive Healing Anti Itch
Cortizone 10 Hydratensive Soothing Anti Itch
Cortizone 10 Intensive Healing
Cortizone 10 Intensive Healing Feminine Itch Relief
Cortizone 10 Intensive Healing For Eczema
Cortizone 10 Plus
Cortizone 10 Poison Ivy Relief Pads
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cvs Anti-itch Hydrocortisone
Cvs Cools Itch Fast
Cvs Cortisone
Cvs Pharmacy Anti-itch
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermacort Anti-Itch
Dermaquest Skin Therapy Post-skin Resurfacing Balm
Dermarest Eczema Medicated
Dermaspray
Dermil
Dermocortal
Dermolate
Dg Health Hydrocortisone
Dg Health Hydrocortisone Cream Maximum Strength
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Dr. Sheffield Hydrocortisone Anti Itch
Drotic
Duane Reade
Duane Reade hydrocortisone
Duane Reade hydrocortisone plus 12 moisturizers
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Equaline Anti Itch
Equaline Anti Itch maximum strength
Equate Hydrocortisone
Esiderm H
Evacort
Family Care Hydrocortisone
Family Wellness
Family Wellness Hydrocortisone
Family Wellness Maximum Strength Hydrocortisone
Ficortril
Fiocortril
Fixmyskin Healing Balm Fragrance-free
Fixmyskin Healing Balm Unflavored
Fixmyskin Healing Balm Vanilla Flavor
Fixmyskin Healing Balm Vanilla Fragrance
Flexicort
Foille Insetti
Formu Care Anti Itch maximum strength
Fulton Street Market Anti Itch
Genacort
Genacort (lotion)
Genuine Hydrocortisone
Glycort
Good Neighbor Pharmacy Anti Itch
Good Neighbor Pharmacy Hydrocortisone
Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers
Good Sense Anti Itch
Gyno-Cortisone
H 4001
H-Cort
H-releve Anti-itch
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Healerz For Itches
Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers
Healthy Accents Cortisone maximum strength
Heb Cort
Heb-Cort
 
Hem-easy Relief Herbal Anti-itch Maximum Itch Relief
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro Skin
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone 1 plus 10
Hydrocortisone Acetate
Hydrocortisone Anti-itch Plus
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone D
Hydrocortisone HC
Hydrocortisone Intensive Healing Formula
Hydrocortisone Maximum Strength
Hydrocortisone Maximum Strength Plus 12 Moisturizers
Hydrocortisone Plus
Hydrocortisone Plus 12 Moisturizers
Hydrocortisone Probutate
Hydrocortisone Regular Strength
Hydrocortisone Sodium Phosphate
Hydrocortisone Ultra Strength
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone anti itch
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone maximum strength
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Intensive Healing Anti Itch
Kaiser Permanente Hydrocortisone
Kendall'S compound F
Kendall's compound F
Kera Hc Hydrocortisone
Kirkland Signature Hydrocortisone Plus maximum strength
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Leader Hydrocortisone
Locoid
Loesch Anti-Itch Therapy
Lopac0_000594
Lubricort
Lucky Supersoft MAXIMUM STRENGTH
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Makesense MAXIMUM STRENGTH
Maximum Strength Cortizone 10 Quick Shot 360 Continuous
Maximum Strength Hydrocortisone
Maximum-h
Medicort
Medpride
Meijer Anti Itch
Meijer Anti Itch Cream Plus
Meijer Hydrocortisone
Meijer Hydrocortisone Plus 12 Moisturizers
Members Mark Hydrocortisone
Meusicort
Mildison
Milliderm
MolPort-001-794-637
Monistat Complete Care Instant Itch Relief
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Natureplex Hydrocortisone Hydro
Neo-Cort-Dome
Neo-Cortef
Neosporin Eczema Essentials Anti Itch
Neosporin-H Ear
Nogenic HC
Nu-derm Tolereen Anti-pruritic
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pandel
Pediaderm Hc
Pediotic Suspension
Penecort
Permicort
Piyanping Antiitch
Polcort H
Premier Value Hydrocortisone
Premier Value Hydrocortisone Plus 12 Moisturizers
Preparation H Hydrocortisone
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proactiv Solution Anti-itch Scalp
Procto-pak
Proctocort
Proctocream HC
Proctofoam
Proctosol-hc
Proctozone HC
Procure
Protocort
Publix Hydro
Publix hydro plus
Quadrydern
Quality Choice Hydrocortisone
Quality Choice Hydrocortisone Maximum Strength
Quality Choice Maximum Strength Anti Itch
Racet
Rectasol-HC
Rectoid
Refuge Hc
Reichstein'S substance M
Reichstein's substance M
Remederm HC
Rexall Anti Itch maximum strength relief
Rexall Hydrocortisone 1
Rexall Hydrocortisone plus moisturizers
Rite Aid anti-itch
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Safeway Hydrocortisone Plus 12 Moisturizers
Sanatison
Scalp-Cort
Scalpicin Anti-Itch Maximum Strength
Scalpicin Capilar
Scalpicin Maximum Strength
Scalpicin Scalp Itch Medication Maximum Strength
Schericur
Scheroson F
Shopko Hydrocortisone
Shopko Hydrocortisone Intensive Healing Formula
Shopko Hydrocortisone Maximum Strength
Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength
Shopko Maximum Strength
Shoprite Hydrocortisone
Sigmacort
Signef
Smart Sense Anti Itch
Smart Sense Anti Itch maximum strength
Smart Sense Hydrocortisone
Solu-cortef
Soothe Rodan Fields
Stie-cort
Stiefcorcil
Sunmark Hydrocortisone
Sunmark Hydrocortisone Plus 12 Moisturizers
Synacort
Systral Hydrocort
Tarcortin
Tecnu Corticool
Texacort
Texacort lotion 25
Thera Plus
Timocort
Topcare Hydrocortisone
Topcare Hydrocortisone Intensive Healing Formula
Topcare Hydrocortisone Plus 12 Moisturizers
Topicort
Transderma H
Traumaide
Truelipids Anti-itch Barrier
U-cort
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Walgreens Hydrocortisone Plus 12 Moisturizers
Westcort
Western Family HydroCortisone
Western Family HydroCortisone Plus 12 Moisturizers
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
2
HyaluronanapprovedPhase 33629067-32-7, 9004-61-953477741, 24759
Synonyms:
Hyaluronate
Hyaluronic acid
Hyaluronic acid sodium salt
Hylartil
Hyruan Plus
Luronit
Macronan
 
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sodium hyaluronate
Sofast
Synvisc
3
butyric acidexperimentalPhase 3292107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
4ViscosupplementsPhase 3267
5Adjuvants, ImmunologicPhase 31783
6Hydrocortisone-17-butyratePhase 3583
7Immunologic FactorsPhase 318483
8Hydrocortisone acetatePhase 3583
9Protective AgentsPhase 35651
10Hydrocortisone 17-butyrate 21-propionatePhase 3583
11AntioxidantsPhase 32442
12Anti-Inflammatory AgentsPhase 3, Phase 28478
13Cortisol succinatePhase 3583
14Dermatologic AgentsPhase 34555
15
BenzocaineapprovedPhase 216841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
16
CisplatinapprovedPhase 2254015663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatin
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinol-aq
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
17
leucovorinapprovedPhase 29521492-18-854575
Synonyms:
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-Folinic acid
(6S)-Leucovorin
(S)-Leucovorin
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinic acid
Folinic acid calcium salt
Folinic acid calcium salt USP27
Folinic acid-SF
Fusilev
 
L-Folinic acid
L-leucovorin
Leucal
Leucovorin
Leucovorin Calcium
Leucovorin calcium
Leucovorin folinic acid
Leucovorin sodium
Leukovorin
Levofolene
Levofolinic acid
Levoleucovorin
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
Wellcovorin
18
CurcuminPhase 2124458-37-7969516
Synonyms:
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Curcuma
Curcumin
Curcumin I
Diferaloylmethane
Diferuloylmethane
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
Hydrastis
 
Indian saffron
Indian turmeric
Kacha haldi
Kurkumin [czech]
Merita earth
Natural yellow 3
Orange root
Safran D'inde
Souchet
Terra merita
Tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric oleoresin (79%-85% curcumin)
Turmeric yellow
Yellow ginger
Yellow puccoon
Yellow root
Yo-kin
Zlut prirodni 3 [Czech]
19Peripheral Nervous System AgentsPhase 218510
20Antirheumatic AgentsPhase 28496
21AnalgesicsPhase 29358
22Analgesics, Non-NarcoticPhase 25184
23Anti-Inflammatory Agents, Non-SteroidalPhase 23549
24TegafurPhase 279
25tannic acidNutraceuticalPhase 21684
26AstragalusNutraceuticalPhase 248

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical StudyCompletedNCT02714543Phase 3
2Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF)Active, not recruitingNCT02645656Phase 2
3A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent ChemoradiotherapyTerminatedNCT01720563Phase 2
4Use of Single Staged Nasolabial Flap in Oral Submucous FibrosisCompletedNCT02711046
5Evaluation of Functional Dimensions of Macintosh Laryngoscope Blade During Direct Laryngoscopy in Patients With Normal Mouth OpeningNot yet recruitingNCT02639897

Search NIH Clinical Center for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

33
Tongue, Breast, Prostate, Endothelial, Thyroid, Heart, Brain

Animal Models for Oral Submucous Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1COL1A1, LOX, MMP2, PTGS2, TGFB1, TIMP1
2MP:00020067.9CDH1, COL1A1, MMP2, PTGS2, TGFB1, TIMP1
3MP:00053797.8CDH1, COL1A1, CYP1A1, PTGS2, TGFB1, TIMP1
4MP:00053877.2CDH1, COL1A1, CYP1A1, MMP2, PTGS2, TGFB1
5MP:00053766.8CDH1, COL1A1, CYP1A1, LOX, MMP2, PTGS2
6MP:00053856.6CDH1, COL1A1, CYP1A1, LOX, MMP2, PTGS2

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 466)
idTitleAuthorsYear
1
Efficacy of nasolabial flap in reconstruction of fibrotomy defect in surgical management of oral submucous fibrosis: a prospective study. (26289230)
2015
2
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut. (26248978)
2015
3
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
4
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
5
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
6
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
7
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
8
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
9
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
10
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
11
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
12
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
13
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
14
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
15
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
16
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
17
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
18
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
19
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
20
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
21
Oral submucous fibrosis in a young patient. (20043056)
2009
22
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
23
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
24
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
25
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
26
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
27
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
28
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
29
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
30
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
31
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
32
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
33
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
34
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
35
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
36
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
37
Oral submucous fibrosis in paediatric age group. (23119548)
1999
38
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
39
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
40
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
41
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
42
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
43
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
44
Oral submucous fibrosis. (3864703)
1985
45
HLA-typing in oral submucous fibrosis. (3864289)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.8MMP2, TGFB1
29.6GSTT1, PTGS2
39.4GSTM1, GSTT1
49.0COL1A1, MMP2, TIMP1
59.0COL1A1, MMP2, TGFB1
68.9CYP1A1, GSTM1, GSTT1
7
Show member pathways
8.9CYP1A1, GSTM1, GSTT1
88.8CDH1, MMP2, PTGS2, TGFB1
98.8CDH1, MMP2, PTGS2, TGFB1
10
Show member pathways
8.5CYP1A1, GSTM1, GSTT1, PTGS2
11
Show member pathways
7.9CDH1, COL1A1, LOX, MMP2, TGFB1, TIMP1

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1cell activationGO:000177510.3TGFB1, TIMP1
2response to radiationGO:000931410.3PTGS2, TGFB1
3negative regulation of cell-cell adhesionGO:002240810.2CDH1, TGFB1
4embryo implantationGO:000756610.1MMP2, PTGS2
5cellular response to organic cyclic compoundGO:007140710.1CYP1A1, TGFB1
6cellular oxidant detoxificationGO:009886910.0GSTT1, PTGS2
7response to steroid hormoneGO:00485459.8COL1A1, LOX
8glutathione metabolic processGO:00067499.8GSTM1, GSTT1
9arachidonic acid metabolic processGO:00193699.8CYP1A1, PTGS2
10response to vitamin DGO:00332809.7PTGS2, TGFB1
11response to organic substanceGO:00100339.7PTGS2, TGFB1
12collagen catabolic processGO:00305749.6COL1A1, MMP2
13cellular response to amino acid stimulusGO:00712309.5COL1A1, MMP2
14positive regulation of epithelial to mesenchymal transitionGO:00107189.5COL1A1, TGFB1
15face morphogenesisGO:00603259.4COL1A1, MMP2, TGFB1
16response to estradiolGO:00323558.6COL1A1, PTGS2, TGFB1
17extracellular matrix disassemblyGO:00226178.6CDH1, COL1A1, MMP2, TIMP1
18response to drugGO:00424938.6COL1A1, CYP1A1, PTGS2, TGFB1
19extracellular matrix organizationGO:00301988.4CDH1, COL1A1, LOX, TGFB1, TIMP1

Sources for Oral Submucous Fibrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet