OSMF
MCID: ORL004
MIFTS: 54

Oral Submucous Fibrosis (OSMF) malady

Rare diseases, Gastrointestinal diseases, Oral diseases categories

Summaries for Oral Submucous Fibrosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition... more...

MalaCards: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to oral cancer and gingivitis, and has symptoms including oropharyngeal neoplasm/tumor/carcinoma/cancer, contractures/cramps/trismus/tetania/claudication/opisthotonos and anomaly of the pharynx/pharyngeal anomaly. An important gene associated with Oral Submucous Fibrosis is LOX (lysyl oxidase), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Matrix Metalloproteinases. The compounds uva 1 and latanoprost have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Oral Submucous Fibrosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Oral diseases


Characteristics (Orphanet epidemiological data):

50
oral submucous fibrosis:
Age of onset: Variable


Aliases & Descriptions:

oral submucous fibrosis 9 44 11 46 50 63
oral submucosal fibrosis, including of tongue 9 63
oral cavity submucous fibrosis 9
oral submucosal fibrosis 9
osmf 50


External Ids:

Disease Ontology9 DOID:5773
ICD9CM28 528.8
NCIt41 C34866
SNOMED-CT59 32883009
ICD10 via Orphanet27 K13.5
ICD1026 K13.5

Related Diseases for Oral Submucous Fibrosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.1GSTT1, MMP1
2gingivitis30.5TIMP1, MMP8, MMP1, CST3
3periodontitis30.5MMP8
4leukoplakia10.8
5oral squamous cell carcinoma10.7
6oral leukoplakia10.6
7burns10.5
8pemphigus10.4
9burning mouth syndrome10.4
10verrucous carcinoma10.4
11papilloma10.4
12ankylosis10.2
13cellulitis10.2
14diabetes mellitus10.2
15disseminated intravascular coagulation10.2
16lipodystrophy10.2
17pemphigus vulgaris10.2
18endotheliitis10.2
19localized scleroderma10.1LOX, MMP1
20conjunctivochalasis10.1MMP1, TIMP1
21pulpitis10.1TIMP1, MMP1
22hypertrophic scars10.1TIMP1, MMP1
23aggressive periodontitis10.1MMP1, MMP8
24pulmonary emphysema10.0MMP1, MMP8
25open-angle glaucoma10.0GSTT1, MMP1
26arthropathy10.0TIMP1, MMP1
27gingival overgrowth10.0LOX, MMP1, TIMP1
28pulmonary fibrosis10.0TIMP1, MMP1, LOX
29systemic scleroderma10.0LOX, MMP1, TIMP1
30idiopathic pulmonary fibrosis10.0MMP1, TIMP1
31laryngeal squamous cell carcinoma10.0MMP1, GSTT1
32keloids10.0LOX, MMP1, MMP8
33keratoconus10.0MMP1, MMP8, TIMP1
34skin disease10.0MMP1, LOX, LOR
35synovitis10.0TIMP1, MMP8, MMP1
36periodontal disease10.0MMP1, MMP8, TIMP1
37ovarian cancer10.0GSTT1, LOX, TIMP1
38endometriosis10.0TIMP1, MMP1, GSTT1
39osteosarcoma10.0LOX, MMP1, TIMP1
40osteoarthritis10.0MMP1, MMP8, TIMP1
41xeroderma pigmentosum10.0XRCC3, GSTT1
42arthritis10.0TIMP1, MMP8, MMP1
43basal cell carcinoma10.0GSTT1, XRCC3, MMP1
44congenital heart disease10.0CST3, MMP1, TIMP1
45squamous cell carcinoma of the head and neck10.0TIMP1, MMP1, LOX, GSTT1
46fibrosarcoma10.0CST3, MMP1, TIMP1
47aneurysm10.0CST3, LOX, MMP8
48breast cancer10.0TIMP1, MMP1, LOX, GSTT1
49asthma10.0TIMP1, MMP8, LOX, GSTT1
50pulmonary disease, chronic obstructive10.0GSTT1, MMP1, MMP8, TIMP1

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Sources:
50Orphanet
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Symptoms:

50
  • oropharyngeal neoplasm/tumor/carcinoma/cancer
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • anomaly of the pharynx/pharyngeal anomaly
  • anomalies of tongue, gingiva and oral mucosa
  • oral mucosa disease/cheilitis
  • limited opening of the mouth

Drugs & Therapeutics for Oral Submucous Fibrosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Oral Submucous Fibrosis

Drug clinical trials:

Search ClinicalTrials for Oral Submucous Fibrosis

Search NIH Clinical Center for Oral Submucous Fibrosis

Search CenterWatch for Oral Submucous Fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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34MalaCards
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MalaCards organs/tissues related to Oral Submucous Fibrosis:

34
Tongue, Skin, Endothelial, T cells, Testes, Salivary gland, Liver

Animal Models for Oral Submucous Fibrosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CST3, MMP1, MMP8, TIMP1
2MP:00053767.2GSTT1, TIMP1, MMP1, LOX, LOR, CST3

Publications for Oral Submucous Fibrosis

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Sources:
53PubMed
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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
2
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
3
Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. (23260769)
2013
4
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. (24237724)
2013
5
Why only areca nut chewing cannot cause oral submucous fibrosis? (23602208)
2013
6
Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation. (22392409)
2012
7
Activation of TGF-I^ pathway by areca nut constituents: a possible cause of oral submucous fibrosis. (23284772)
2012
8
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
9
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
10
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
11
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
12
Surgical management of oral submucous fibrosis in an edentulous patient: A procedural challenge. (22442590)
2010
13
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
14
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
15
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
16
Oral submucous fibrosis in a young patient. (20043056)
2009
17
New graft-stabilizing clip as a treatment adjunct for oral submucous fibrosis. (19703627)
2009
18
Prevalence of leukoplakia, oral submucous fibrosis, papilloma and its relation with stress among green marbles mine laborers, India. (18978707)
2008
19
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
20
Quantitative dimensions of histopathological attributes and status of GSTM1-GSTT1 in oral submucous fibrosis. (18573513)
2008
21
Interventions for the management of oral submucous fibrosis. (18843745)
2008
22
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
23
Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. (17217211)
2006
24
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
25
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
26
The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. (15752081)
2005
27
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
28
Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro. (15641989)
2005
29
Polymorphism of the MICA gene and risk for oral submucous fibrosis. (14675133)
2004
30
Alterations in expression of retinoid receptor beta and p53 in oral submucous fibrosis. (15196140)
2004
31
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
32
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
33
Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. (10899674)
2000
34
Raised tissue copper levels in oral submucous fibrosis. (10890553)
2000
35
Oral submucous fibrosis in paediatric age group. (23119548)
1999
36
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
37
Increased severity of oral submucous fibrosis in young Pakistani men. (9291269)
1997
38
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
39
Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). (7529836)
1994
40
Oral submucous fibrosis. (8069214)
1994
41
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
42
Oral submucous fibrosis: its pathogenesis and management. (3459494)
1986
43
Oral submucous fibrosis. (3864703)
1985
44
HLA-typing in oral submucous fibrosis. (3864289)
1985
45
Malignant transformation rate in oral submucous fibrosis over a 17-year period. (3866655)
1985
46
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
47
Oral submucous fibrosis in a Greek female. (6945122)
1981
48
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979
49
Oral submucous fibrosis. A possible case in a person of Caucasian descent. (5227788)
1967
50
Subepithelial changes in oral submucous fibrosis. (6050369)
1967

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oral Submucous Fibrosis

Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 13EMD Millipore
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Compounds for genes affiliated with Oral Submucous Fibrosis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1uva 14610.1MMP1, TIMP1
2latanoprost46 1211.0MMP1, TIMP1
3grgdsp4610.0TIMP1, MMP1
4nimesulide46 1211.0TIMP1, MMP1
5u01264610.0MMP1, TIMP1
6lutein469.9TIMP1, MMP1
7hocl469.9TIMP1, MMP8
8clodronate46 52 1211.8MMP8, MMP1
9hydroxyproline46 25 1211.8LOX, MMP1, TIMP1
10kt 572046 62 3011.8MMP1, TIMP1
11pyridinoline469.8TIMP1, LOX
12procollagen469.7LOX, MMP1, TIMP1
13alpha tocopherol469.7LOX, MMP1, TIMP1
14uk 383367629.7MMP8, MMP1
15gi 254023x629.7MMP8, MMP1
16carbon469.7LOX, MMP1, TIMP1
17curcumin469.7LOX, MMP1, TIMP1
18gm 6001629.7MMP8, MMP1
19prostaglandin469.7TIMP1, MMP1, LOX
20(4-aminophenyl)mercuric acetate469.6TIMP1, MMP8, MMP1
21hydroxamate469.6MMP1, MMP8, TIMP1
22marimastat46 62 1211.6TIMP1, MMP8, MMP1
23aspirin46 52 30 2512.6LOX, MMP1, TIMP1
24alendronate46 52 1211.6MMP1, MMP8, TIMP1
25batimastat46 62 1211.6TIMP1, MMP8, MMP1
26doxycycline46 1210.6TIMP1, MMP8, MMP1
27indomethacin46 30 62 1212.3LOX, MMP1, TIMP1
28glycosaminoglycan469.3TIMP1, MMP8, MMP1, LOX
29aprotinin46 1210.3TIMP1, MMP1, CST3
30benzene469.2GSTT1, XRCC3
31pge2469.2TIMP1, MMP8, MMP1, LOX
32h2o2469.2TIMP1, MMP8, MMP1, LOX
33urea46 25 1211.1MMP8, LOX, CST3
34methotrexate52 46 1211.1CST3, MMP1, TIMP1
35matrigel468.9TIMP1, MMP1, LOX, CST3
36ascorbic acid46 259.9GSTT1, LOX, MMP1
37p003468.9XRCC3, CST3, GSTT1
38vitamin a46 25 1210.8TIMP1, MMP1, LOR, CST3
39dexamethasone46 52 30 1211.8CST3, LOX, MMP1, TIMP1
40retinoic acid46 259.8LOR, LOX, MMP1, MMP8, TIMP1
41cyclosporin a46 30 6210.7TIMP1, MMP8, MMP1, CST3
42p002468.7GSTT1, CST3, MMP8, TIMP1
43folate468.6TIMP1, XRCC3, CST3, GSTT1
44lactate468.4TIMP1, MMP8, MMP1, LOX, CST3
45vegf468.4TIMP1, MMP8, MMP1, LOX, CST3
46cysteine468.4TIMP1, MMP8, MMP1, LOX, CST3
47n acetylcysteine468.4CST3, XRCC3, LOX, MMP1, TIMP1
48cisplatin46 52 62 1211.2GSTT1, CST3, XRCC3, LOX, TIMP1
49serine468.2TIMP1, MMP8, MMP1, LOR, CST3
50lipid468.2GSTT1, CST3, LOR, LOX, MMP8

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Sources:
17Gene Ontology
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Cellular components related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0CST3, LOX, MMP1, MMP8, TIMP1

Biological processes related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endopeptidase activityGO:0109519.3CST3, TIMP1
2collagen catabolic processGO:0305749.2MMP1, MMP8
3extracellular matrix disassemblyGO:0226179.1TIMP1, MMP8, MMP1
4extracellular matrix organizationGO:0301988.8LOX, MMP1, MMP8, TIMP1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3CST3, TIMP1

Products for genes affiliated with Oral Submucous Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Oral Submucous Fibrosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet