MCID: ORL004
MIFTS: 52

Oral Submucous Fibrosis malady

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Oral Submucous Fibrosis

About this section
Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Oral Submucous Fibrosis:

Name: Oral Submucous Fibrosis 11 46 13 52 48 37 66
Oral Submucosal Fibrosis, Including of Tongue 11 66
Osmf 46 52
 
Oral Cavity Submucous Fibrosis 11
Oral Submucosal Fibrosis 11

Characteristics:

Orphanet epidemiological data:

52
oral submucous fibrosis:
Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:5773
ICD1028 K13.5
ICD9CM30 528.8
MeSH37 D009914
SNOMED-CT60 32883009
NCIt43 C34866
Orphanet52 ORPHA357154
ICD10 via Orphanet29 K13.5

Summaries for Oral Submucous Fibrosis

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Wikipedia:69 Oral submucous fibrosis (OSMF or OSF) is a chronic, complex, premalignant ( 1% transformation risk )... more...

MalaCards based summary: Oral Submucous Fibrosis, also known as oral submucosal fibrosis, including of tongue, is related to gingivitis and oral lichen planus, and has symptoms including abnormality of the oral cavity, trismus and abnormality of the pharynx. An important gene associated with Oral Submucous Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways are Syndecan-1-mediated signaling events and Etoposide Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include tongue, skin and endothelial, and related mouse phenotypes are integument and muscle.

Related Diseases for Oral Submucous Fibrosis

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Diseases related to Oral Submucous Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1gingivitis30.1MMP9, TGFB1, TIMP1
2oral lichen planus28.0CDH1, CYP1A1, GSTM1, GSTT1, MMP9, PTGS2
3leukoplakia10.5
4oral pharyngeal disorders10.5GSTM1, GSTT1
5keratopathy10.5MMP2, TGFB1
6oral squamous cell carcinoma10.5
7levic stefanovic nikolic syndrome10.4GSTM1, GSTT1
8diamond-blackfan anemia10.4MMP9, TGFB1
9oral leukoplakia10.4
10fibromatosis, gingival, 110.4MMP2, TGFB1
11oral cancer10.4
12emery-dreifuss muscular dystrophy, dominant type10.4GSTM1, GSTT1
13asbestosis10.3GSTM1, GSTT1, TGFB1
14xanthomatosis10.3PTGS2, TGFB1, TIMP1
15zellweger-like syndrome without peroxisomal anomalies10.3MMP2, MMP9
16pathological gambling10.3MMP2, MMP9
17myosin storage myopathy10.3MMP2, MMP9
18renal pelvis carcinoma10.3MMP2, MMP9
19meningothelial meningioma10.3MMP2, MMP9
20emphysematous cholecystitis10.3MMP2, MMP9
21deletion 5q3510.2MMP2, MMP9
22inhalation anthrax10.2MMP9, TIMP1
23sialadenitis10.2MMP2, MMP9
24reading disorder10.2MMP2, MMP9
25cyclosporiasis10.2MMP2, MMP9
26limb reduction defect10.2MMP2, MMP9
27salt and pepper syndrome10.2MMP2, TGFB1, TIMP1
28granulomatous orchitis10.2MMP2, TGFB1, TIMP1
29tubular adenocarcinoma10.1MMP2, MMP9
30multiple system atrophy, cerebellar type10.1CYP1A1, GSTM1
31retinal degeneration10.1MMP2, MMP9
32burns10.1
33verrucous carcinoma10.1
34pemphigus10.1
35benign struma ovarii10.1CDH1, PTGS2, TGFB1
36urticaria10.1GSTM1, MMP9, PTGS2
37immunodeficiency 27b, mycobacteriosis, ad10.1MMP9, PTGS2, TIMP1
38diplegia of upper limb10.1CYP1A1, GSTM1, GSTT1
39pulpitis10.1MMP9, TGFB1, TIMP1
40burn scar10.1MMP9, TGFB1, TIMP1
41pauciarticular onset juvenile idiopathic arthritis10.1MMP2, MMP9
42ulcerative stomatitis10.1GSTM1, GSTT1
43plasma protein metabolism disease10.1CDH1, PTGS2, TGFB1
44adrenal rest tumor10.1MMP9, PTGS2, TGFB1
45adenosine monophosphate deaminase 1 deficiency10.1MMP2, MMP9, PTGS2
46hidrocystoma10.0CYP1A1, GSTM1, GSTT1
47frontotemporal lobar degeneration with ubiquitin-positive inclusions10.0COL1A1, TGFB1
48pemphigus vulgaris10.0
49papilloma10.0
50burning mouth syndrome10.0

Graphical network of the top 20 diseases related to Oral Submucous Fibrosis:



Diseases related to oral submucous fibrosis

Symptoms for Oral Submucous Fibrosis

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Symptoms:

 52 (show all 7)
  • narrow mouth
  • abnormality of the oral cavity
  • trismus
  • abnormality of the pharynx
  • flexion contracture
  • oropharyngeal squamous cell carcinoma
  • cheilitis

HPO human phenotypes related to Oral Submucous Fibrosis:

id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 trismus hallmark (90%) HP:0000211
3 abnormality of the pharynx hallmark (90%) HP:0000600
4 cheilitis hallmark (90%) HP:0100825
5 flexion contracture typical (50%) HP:0001371

UMLS symptoms related to Oral Submucous Fibrosis:


oral manifestations, chapping of lips, pigmentation lip, oral mucosa atrophy

Drugs & Therapeutics for Oral Submucous Fibrosis

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Drugs for Oral Submucous Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
HydrocortisonePhase 360250-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11╬▓-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
2
Hyaluronic acidPhase 34199004-61-953477741, 24759
Synonyms:
Hyaluronan
Hyaluronate
Hyaluronic acid
Hylartil
Hyruan Plus
Luronit
 
Macronan
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sofast
Synvisc
3
butyric acidPhase 3350107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
4
CurcuminPhase 2131458-37-7969516
Synonyms:
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Curcuma
Curcumin
Curcumin I
Diferaloylmethane
Diferuloylmethane
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
Hydrastis
 
Indian saffron
Indian turmeric
Kacha haldi
Kurkumin [czech]
Merita earth
Natural yellow 3
Orange root
Safran D'inde
Souchet
Terra merita
Tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric oleoresin (79%-85% curcumin)
Turmeric yellow
Yellow ginger
Yellow puccoon
Yellow root
Yo-kin
Zlut prirodni 3 [Czech]
5
BenzocainePhase 217941994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
6TegafurPhase 28417902-23-7
7
leucovorinPhase 2104758-05-9143, 54575
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
8
CisplatinPhase 2261415663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
9tannic acidNutraceuticalPhase 21794

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical StudyCompletedNCT02714543Phase 3
2Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF)Active, not recruitingNCT02645656Phase 2
3A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent ChemoradiotherapyTerminatedNCT01720563Phase 2
4Use of Single Staged Nasolabial Flap in Oral Submucous FibrosisCompletedNCT02711046
5Evaluation of Functional Dimensions of Macintosh Laryngoscope Blade During Direct Laryngoscopy in Patients With Normal Mouth OpeningNot yet recruitingNCT02639897

Search NIH Clinical Center for Oral Submucous Fibrosis


Cochrane evidence based reviews: oral submucous fibrosis

Genetic Tests for Oral Submucous Fibrosis

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Anatomical Context for Oral Submucous Fibrosis

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MalaCards organs/tissues related to Oral Submucous Fibrosis:

34
Tongue, Skin, Endothelial, T cells, Testes, Salivary gland, Liver

Animal Models for Oral Submucous Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Oral Submucous Fibrosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1CDH1, COL1A1, LOX, MMP9, PTGS2, TGFB1
2MP:00053698.1COL1A1, LOX, MMP2, MMP9, PTGS2, TGFB1
3MP:00053887.8COL1A1, LOX, MMP2, MMP9, PTGS2, TGFB1
4MP:00020067.5CDH1, COL1A1, MMP2, MMP9, PTGS2, TGFB1
5MP:00053877.2CDH1, COL1A1, CYP1A1, MMP2, MMP9, PTGS2
6MP:00053766.6CDH1, COL1A1, CYP1A1, LOX, MMP2, MMP9
7MP:00107686.5CDH1, COL1A1, CYP1A1, LOX, MMP2, MMP9
8MP:00053856.3CDH1, COL1A1, CYP1A1, LOX, MMP2, MMP9

Publications for Oral Submucous Fibrosis

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Articles related to Oral Submucous Fibrosis:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis. (27533088)
2016
2
A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients. (26991343)
2016
3
Response to Oral epithelial dysplasia in oral submucous fibrosis: A challenge. (26786963)
2016
4
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut. (26248978)
2015
5
Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. (25136423)
2014
6
Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. (25015036)
2014
7
Malignant potential of oral submucous fibrosis due to intraoral extraction wounds and poor oral hygiene. (24182843)
2014
8
Cross-arch arrangement in complete denture prosthesis to manage an edentulous patient with oral submucous fibrosis and abnormal jaw relation. (25239981)
2014
9
Oral submucous fibrosis: a review article on etiopathogenesis. (25552225)
2014
10
Quantitative analysis of serum levels of trace elements in patients with oral submucous fibrosis and oral squamous cell carcinoma: A randomized cross-sectional study. (24959037)
2014
11
Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma. (24930755)
2014
12
Biochemical markers in oral submucous fibrosis: A review and update. (24348612)
2013
13
Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity. (24899319)
2013
14
Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis. (23250779)
2012
15
Increased expression of CK8 and CK18 in leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma: an immunohistochemistry study. (22677743)
2012
16
Pentoxifylline therapy in the management of oral submucous fibrosis. (21790236)
2011
17
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. (21171082)
2011
18
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A. (21920672)
2011
19
Evaluation of myofibroblasts in oral submucous fibrosis: correlation with disease severity. (21198872)
2011
20
Areca nut in pathogenesis of oral submucous fibrosis: revisited. (20376683)
2011
21
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. (20630073)
2010
22
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. (20516538)
2010
23
Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. (20863370)
2010
24
In vivo native fluorescence spectroscopy and nicotinamide adinine dinucleotide/flavin adenine dinucleotide reduction and oxidation states of oral submucous fibrosis for chemopreventive drug monitoring. (20210484)
2010
25
Oral submucous fibrosis in a young patient. (20043056)
2009
26
New graft-stabilizing clip as a treatment adjunct for oral submucous fibrosis. (19703627)
2009
27
An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. (18205743)
2008
28
Interventions for the management of oral submucous fibrosis. (18843745)
2008
29
Efficacy of oral lycopene in the management of oral submucous fibrosis. (17234538)
2007
30
Strong association between areca nut use and oral submucous fibrosis. (17003801)
2006
31
Surgical management of trismus due to Oral Submucous Fibrosis - Lysis of fibrotic bands with the KTP-532 Laser. (23120299)
2006
32
Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. (16276024)
2005
33
The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. (16054426)
2005
34
Alterations in expression of retinoid receptor beta and p53 in oral submucous fibrosis. (15196140)
2004
35
Oral submucous fibrosis with its possible effect on eustachian tube functions: A tympanometric study. (23120070)
2004
36
The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. (12676256)
2003
37
Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature. (12121538)
2002
38
Altered elemental profile as indicator of homeostatic imbalance in pathogenesis of oral submucous fibrosis. (12117232)
2002
39
Oral submucous fibrosis patients have altered levels of cytokine production. (10738939)
2000
40
Oral submucous fibrosis, areca nut and pan masala use: a case-control study. (10083804)
1998
41
Oral submucous fibrosis and copper. (9250210)
1997
42
Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases. (8537913)
1995
43
Oral submucous fibrosis. (8069214)
1994
44
Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer. (1544110)
1992
45
An alternative pathogenetic pathway for oral submucous fibrosis (OSMF). (2796807)
1989
46
Semi-quantitative clinical description of oral submucous fibrosis. (3481529)
1987
47
Oral submucous fibrosis. (3864703)
1985
48
HLA-typing in oral submucous fibrosis. (3864289)
1985
49
Oral submucous fibrosis as a precancerous condition. (6589738)
1984
50
Oral submucous fibrosis in a patient with pemphigus vulgaris. (509775)
1979

Variations for Oral Submucous Fibrosis

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Expression for genes affiliated with Oral Submucous Fibrosis

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Search GEO for disease gene expression data for Oral Submucous Fibrosis.

Pathways for genes affiliated with Oral Submucous Fibrosis

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Pathways related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.7MMP9, TGFB1
29.6GSTT1, PTGS2
39.6MMP2, MMP9
49.6MMP2, MMP9
59.4GSTM1, GSTT1
6
Show member pathways
9.3MMP2, MMP9, TIMP1
79.1CDH1, MMP2, MMP9
89.1CDH1, MMP2, MMP9
99.1CDH1, MMP2, MMP9
109.0COL1A1, MMP2, TGFB1
11
Show member pathways
9.0CYP1A1, GSTM1, GSTT1
129.0CYP1A1, GSTM1, GSTT1
13
Show member pathways
8.8CDH1, MMP2, MMP9, TGFB1
14
Show member pathways
8.6MMP2, MMP9, PTGS2, TGFB1, TIMP1
15
Show member pathways
8.6CYP1A1, GSTM1, GSTT1, PTGS2
168.5COL1A1, MMP2, MMP9, TIMP1
178.4CDH1, MMP2, MMP9, PTGS2, TGFB1
188.4CDH1, MMP2, MMP9, PTGS2, TGFB1
19
Show member pathways
7.4CDH1, COL1A1, LOX, MMP2, MMP9, TGFB1

GO Terms for genes affiliated with Oral Submucous Fibrosis

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Cellular components related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.9COL1A1, MMP2, TGFB1, TIMP1
2proteinaceous extracellular matrixGO:00055788.1COL1A1, LOX, MMP2, MMP9, TGFB1, TIMP1
3extracellular spaceGO:00056157.9COL1A1, LOX, MMP2, MMP9, TGFB1, TIMP1
4extracellular regionGO:00055767.1CDH1, COL1A1, LOX, MMP2, MMP9, TGFB1

Biological processes related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1cell activationGO:000177510.4TGFB1, TIMP1
2negative regulation of cell-cell adhesionGO:002240810.3CDH1, TGFB1
3positive regulation of vascular endothelial growth factor productionGO:001057510.2PTGS2, TGFB1
4response to immobilization stressGO:003590210.2CYP1A1, TGFB1
5response to vitamin DGO:003328010.2PTGS2, TGFB1
6endodermal cell differentiationGO:003598710.2MMP2, MMP9
7glutathione derivative biosynthetic processGO:190168710.1GSTM1, GSTT1
8positive regulation of vascular smooth muscle cell proliferationGO:19047079.9MMP2, MMP9
9bone trabecula formationGO:00603469.9COL1A1, MMP2
10intramembranous ossificationGO:00019579.8COL1A1, MMP2
11response to organic cyclic compoundGO:00140709.8CYP1A1, PTGS2, TGFB1
12response to hyperoxiaGO:00550939.7COL1A1, CYP1A1
13embryo implantationGO:00075669.6MMP2, MMP9, PTGS2
14cellular response to mechanical stimulusGO:00712609.5COL1A1, PTGS2, TGFB1
15response to hypoxiaGO:00016669.4CYP1A1, MMP2, TGFB1
16face morphogenesisGO:00603259.3COL1A1, MMP2, TGFB1
17collagen catabolic processGO:00305749.3COL1A1, MMP2, MMP9
18response to estradiolGO:00323559.2COL1A1, PTGS2, TGFB1
19extracellular matrix disassemblyGO:00226179.1CDH1, MMP2, MMP9, TIMP1
20response to organic substanceGO:00100338.9CDH1, CYP1A1, PTGS2, TGFB1, TIMP1
21wound healingGO:00420608.8COL1A1, LOX, TGFB1, TIMP1
22extracellular matrix organizationGO:00301988.6CDH1, COL1A1, LOX, MMP9
23response to drugGO:00424937.5CDH1, COL1A1, CYP1A1, LOX, PTGS2, TGFB1

Molecular functions related to Oral Submucous Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198998.8CYP1A1, GSTM1, PTGS2, TGFB1

Sources for Oral Submucous Fibrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
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43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet