MCID: ORB011
MIFTS: 25

Orbit Rhabdomyosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Orbit Rhabdomyosarcoma

Aliases & Descriptions for Orbit Rhabdomyosarcoma:

Name: Orbit Rhabdomyosarcoma 12 14
Rhabdomyosarcoma of the Orbit 12 42 69
Rhabdomyosarcoma of Orbit 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3259
MeSH 42 C537605
NCIt 47 C4543
SNOMED-CT 64 254994000
UMLS 69 C0346347

Summaries for Orbit Rhabdomyosarcoma

MalaCards based summary : Orbit Rhabdomyosarcoma, also known as rhabdomyosarcoma of the orbit, is related to orbit embryonal rhabdomyosarcoma and orbit alveolar rhabdomyosarcoma. An important gene associated with Orbit Rhabdomyosarcoma is MB (Myoglobin). The drugs Cyclophosphamide and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are embryo and muscle

Related Diseases for Orbit Rhabdomyosarcoma

Graphical network of the top 20 diseases related to Orbit Rhabdomyosarcoma:



Diseases related to Orbit Rhabdomyosarcoma

Symptoms & Phenotypes for Orbit Rhabdomyosarcoma

MGI Mouse Phenotypes related to Orbit Rhabdomyosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.33 MB MYOG NF1
2 muscle MP:0005369 9.13 MB MYOG NF1
3 respiratory system MP:0005388 8.8 MB MYOG NF1

Drugs & Therapeutics for Orbit Rhabdomyosarcoma

Drugs for Orbit Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Dactinomycin Approved Phase 2 50-76-0 2019 457193
3
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
4 Alkylating Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Antibiotics, Antitubercular Phase 2
7 Anti-Infective Agents Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Alkylating Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2
11 Antirheumatic Agents Phase 2
12 Immunosuppressive Agents Phase 2
13 Nucleic Acid Synthesis Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Embryonal Rhabdomyosarcoma Unknown status NCT00245141 Phase 2

Search NIH Clinical Center for Orbit Rhabdomyosarcoma

Cochrane evidence based reviews: rhabdomyosarcoma of the orbit

Genetic Tests for Orbit Rhabdomyosarcoma

Anatomical Context for Orbit Rhabdomyosarcoma

MalaCards organs/tissues related to Orbit Rhabdomyosarcoma:

39
Skin

Publications for Orbit Rhabdomyosarcoma

Articles related to Orbit Rhabdomyosarcoma:

(show all 18)
id Title Authors Year
1
Canine orbital rhabdomyosarcoma: a report of 18 cases. ( 25846977 )
2015
2
Orbital rhabdomyosarcoma with skin metastasis: a case report. ( 25253623 )
2014
3
Multidisciplinary management of adult orbital rhabdomyosarcoma*. ( 23617582 )
2013
4
HPA1 and components of the hedgehog signaling pathway are increased in untreated alveolar orbital rhabdomyosarcoma. ( 23777428 )
2013
5
Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma. ( 24083717 )
2013
6
Limits and chances in an unfortunate course of recurrent orbital rhabdomyosarcoma. ( 21876600 )
2011
7
Malignant hemophtalmus as a first sign of orbital rhabdomyosarcoma in adult. ( 22372339 )
2011
8
Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. ( 21421211 )
2011
9
Orbital rhabdomyosarcoma in Li-Fraumeni syndrome. ( 17420382 )
2007
10
Optic pathway glioma associated with orbital rhabdomyosarcoma and bilateral optic nerve sheath dural ectasia in a child with neurofibromatosis-1. ( 16941184 )
2006
11
Orbital rhabdomyosarcoma: relationship between DNA ploidy, p53, bcl-2, MDR-1 and Ki67 (MIB1) expression and clinical behavior. ( 15015604 )
2004
12
[Clinical significance of mdm2 and p53 expression in orbital rhabdomyosarcoma]. ( 15634483 )
2004
13
Orbital rhabdomyosarcoma in Noonan syndrome. ( 12679651 )
2003
14
Incomplete Beckwith-Wiedemann syndrome in a child with orbital rhabdomyosarcoma. ( 11910143 )
2002
15
[Point mutations of N-ras oncogene and abnormal expression of rasp21, p53 proteins in orbital rhabdomyosarcoma]. ( 11853610 )
2000
16
Development of ganglioneuroma following successful treatment for orbital rhabdomyosarcoma. ( 9659120 )
1998
17
Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. ( 2119961 )
1990
18
Medical therapy of orbit rhabdomyosarcoma in children. ( 7143084 )
1982

Variations for Orbit Rhabdomyosarcoma

Expression for Orbit Rhabdomyosarcoma

Search GEO for disease gene expression data for Orbit Rhabdomyosarcoma.

Pathways for Orbit Rhabdomyosarcoma

GO Terms for Orbit Rhabdomyosarcoma

Biological processes related to Orbit Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.26 MYOG NF1
2 heart development GO:0007507 9.16 MB NF1
3 response to hypoxia GO:0001666 8.96 MB NF1
4 skeletal muscle tissue development GO:0007519 8.62 MYOG NF1

Sources for Orbit Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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