MCID: ORB011
MIFTS: 41

Orbit Rhabdomyosarcoma malady

Summaries for Orbit Rhabdomyosarcoma

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32MalaCards
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MalaCards: Orbit Rhabdomyosarcoma, also known as rhabdomyosarcoma of the orbit, is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Orbit Rhabdomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and DNA damage Role of SUMO in p53 regulation. The compounds creatinine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include bone and liver, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Orbit Rhabdomyosarcoma

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8Disease Ontology, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

orbit rhabdomyosarcoma 8
rhabdomyosarcoma of the orbit 8 60
rhabdomyosarcoma of orbit 8


External Ids:

Disease Ontology8 DOID:3259
MeSH34 C537605
SNOMED-CT56 254994000
NCIt39 C4543

Related Diseases for Orbit Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Orbit Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma31.0DES, MB
2rhabdomyosarcoma30.9VIM, MB, MDM2, DES, ABCB1, ENO2
3alveolar rhabdomyosarcoma30.2MB, MDM2, DES, ENO2
4sarcoma30.1VIM, MB, MDM2, DES, ABCB1, ENO2
5li-fraumeni syndrome30.0MDM2, TP53
6orbit embryonal rhabdomyosarcoma10.7
7orbit alveolar rhabdomyosarcoma10.2
8neurofibromatosis10.2
9liver rhabdomyosarcoma10.2
10noonan syndrome10.0
11beckwith-wiedemann syndrome10.0
12ganglioneuroma10.0
13optic nerve glioma10.0
14rhabdoid cancer10.0ENO2
15cerebral primitive neuroectodermal tumor10.0ENO2
16hemangioblastoma10.0ENO2
17epulis10.0ENO2
18subependymal giant cell astrocytoma10.0ENO2
19teratoma10.0ENO2
20seminoma10.0ENO2
21merkel cell carcinoma10.0ENO2
22peritonitis10.0MB
23neuropathy10.0MB
24infantile myofibromatosis10.0DES
25rheumatoid arthritis10.0MB
26arthritis10.0MB
27dermatofibrosarcoma10.0MDM2
28schizophrenia10.0MB
29giant cell glioblastoma10.0MDM2
30nephroblastoma10.0TP53
31ischemia10.0MB
32ductal carcinoma in situ10.0TP53
33endometrial carcinoma10.0TP53
34benign mesothelioma10.0TP53
35benign meningioma10.0MDM2
36cholangiocarcinoma10.0TP53
37myositis10.0MB
38thyroid cancer10.0TP53
39angiosarcoma10.0VIM
40myoepithelioma10.0VIM
41ulcerative colitis10.0TP53
42meningioma10.0VIM
43choroid plexus papilloma10.0TP53
44epidermolysis bullosa simplex10.0DES
45pheochromocytoma10.0ENO2
46ganglioglioma10.0ENO2
47tuberous sclerosis10.0VIM
48adenomatoid tumor10.0VIM
49anaplastic oligodendroglioma10.0MDM2
50perineurioma10.0VIM

Graphical network of the top 20 diseases related to Orbit Rhabdomyosarcoma:



Diseases related to orbit rhabdomyosarcoma

Clinical Features for Orbit Rhabdomyosarcoma

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Drugs & Therapeutics for Orbit Rhabdomyosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Orbit Rhabdomyosarcoma

Drug clinical trials:

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Search NIH Clinical Center for Orbit Rhabdomyosarcoma

Search CenterWatch for Orbit Rhabdomyosarcoma

Genetic Tests for Orbit Rhabdomyosarcoma

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Anatomical Context for Orbit Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Orbit Rhabdomyosarcoma:

32
Bone, Liver

Animal Models for Orbit Rhabdomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Orbit Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7MB, MDM2, TP53
2MP:00053857.3TP53, ABCB1, DES, MDM2, MB, VIM
3MP:00107687.3TP53, ABCB1, DES, MDM2, MB, VIM
4MP:00053867.2VIM, MDM2, DES, ABCB1, ENO2, TP53
5MP:00053846.8VIM, MB, MDM2, ABCB1, ENO2, TP53

Publications for Orbit Rhabdomyosarcoma

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50PubMed
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Articles related to Orbit Rhabdomyosarcoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Outcome of patients with localized orbital sarcoma who relapsed following treatment on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-III and -IV, 1984-1997: a report from the Children's Oncology Group. (22961750)
2013
2
Multidisciplinary management of adult orbital rhabdomyosarcoma*. (23617582)
2013
3
HPA1 and components of the hedgehog signaling pathway are increased in untreated alveolar orbital rhabdomyosarcoma. (23777428)
2013
4
Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma. (24083717)
2013
5
Orbital embryonal rhabdomyosarcoma with metastasis in a young dog. (22304975)
2012
6
Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old. (24269390)
2012
7
Limits and chances in an unfortunate course of recurrent orbital rhabdomyosarcoma. (21876600)
2011
8
Detection of bone metastases in initial staging of orbital embryonal rhabdomyosarcoma by fluorodeoxyglucose positron emission tomography/computed tomography. (23487301)
2011
9
Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. (21421211)
2011
10
Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. (21242849)
2011
11
Malignant hemophtalmus as a first sign of orbital rhabdomyosarcoma in adult. (22372339)
2011
12
A strategy to avoid facial mutilation in orbital embryonal rhabdomyosarcoma. (20143115)
2010
13
Two cases of orbital embryonal rhabdomyosarcoma with chromosome aberration]. (20432963)
2010
14
Orbital rhabdomyosarcoma in Li-Fraumeni syndrome. (17420382)
2007
15
Alveolar rhabdomyosarcoma presenting as an acute orbital mass in the medial rectus muscle. (17413634)
2007
16
Pathology teach and tell: solid variant alveolar rhabdomyosarcoma of the orbit. (16754488)
2006
17
A case of alveolar rhabdomyosarcoma of the ethmoid sinus invading the orbit in an adult. (16768194)
2006
18
Optic pathway glioma associated with orbital rhabdomyosarcoma and bilateral optic nerve sheath dural ectasia in a child with neurofibromatosis-1. (16941184)
2006
19
Treatment of embryonal rhabdomyosarcoma of the sinus and orbit with chemotherapy, radiation, and endoscopic surgery. (16769322)
2006
20
Pediatric malignancies. Case 1. Hypermethylation in orbital alveolar rhabdomyosarcoma. (16034055)
2005
21
Orbital embryonal rhabdomyosarcoma in Karachi (1998-2002). (15623182)
2004
22
Clinical significance of mdm2 and p53 expression in orbital rhabdomyosarcoma]. (15634483)
2004
23
Orbital rhabdomyosarcoma: relationship between DNA ploidy, p53, bcl-2, MDR-1 and Ki67 (MIB1) expression and clinical behavior. (15015604)
2004
24
Embryonal rhabdomyosarcoma of the orbit in a liver transplant recipient. (12819877)
2003
25
Orbital rhabdomyosarcoma in Noonan syndrome. (12679651)
2003
26
Incomplete Beckwith-Wiedemann syndrome in a child with orbital rhabdomyosarcoma. (11910143)
2002
27
Management of alveolar rhabdomyosarcoma of the orbit. (12485290)
2002
28
Letter to the editor: neurofibromatosis type 1 (NF 1) associated with embryonal rhabdomyosarcoma of the orbit. (11984810)
2002
29
Microsatellite instability in three cases of embryonal rhabdomyosarcoma of the orbit. (12116063)
2002
30
Embryonal rhabdomyosarcoma of the orbit in a 38-year-old woman. (11338467)
2001
31
Point mutations of N-ras oncogene and abnormal expression of rasp21, p53 proteins in orbital rhabdomyosarcoma]. (11853610)
2000
32
Development of ganglioneuroma following successful treatment for orbital rhabdomyosarcoma. (9659120)
1998
33
Loss of heterozygosity on the long arm of chromosome 11 in orbital embryonal rhabdomyosarcoma (OERMS): a microsatellite study of seven cases. (12048708)
1998
34
Findings of magnetic resonance and colour-flow Doppler imaging of orbital embryonal rhabdomyosarcoma. (8193970)
1994
35
Embryonal rhabdomyosarcoma of the orbit in a 35-year-old man. (8058268)
1994
36
Alveolar rhabdomyosarcoma that metastasized to the orbit. (8155037)
1993
37
Embryonal rhabdomyosarcoma of orbit--a case report. (2086480)
1990
38
Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. (2119961)
1990
39
Congenital orbital alveolar rhabdomyosarcoma. (6579973)
1983
40
Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. (6654047)
1983
41
Medical therapy of orbit rhabdomyosarcoma in children. (7143084)
1982
42
Orbital embryonal rhabdomyosarcoma and intracranial schwannoma. (314794)
1979
43
Electron microscopic and electron histochemical studies on embryonal rhabdomyosarcoma of the orbit. (169642)
1975
44
Orbital cellulitis and cavernous sinus thrombosis caused by rhabdomyosarcoma of the middle ear. (4640733)
1972
45
Intracranial extension of a non-striated embryonal rhabdomyosarcoma of the orbit. (5777351)
1969
46
X-ray treatment of embryonal rhabdomyosarcoma of orbit. Case report of a 13-year survival without recurrence. (5729593)
1968
47
Alveolar rhabdomyosarcoma of paranasal sinuses and orbit. (5646034)
1968
48
Embryonal rhabdomyosarcoma of the orbit. (6079091)
1967
49
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965
50
Embryonal rhabdomyosarcoma of the orbit in children and young adults. (13669797)
1959

Genetic Variations for Orbit Rhabdomyosarcoma

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Expression for genes affiliated with Orbit Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Orbit Rhabdomyosarcoma

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Pathways for genes affiliated with Orbit Rhabdomyosarcoma

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Orbit Rhabdomyosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Orbit Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1creatinine4410.2MB
2acetylcholine44 49 28 11 2413.9MB, ENO2
3orcein449.9DES, VIM
4ctab449.8MB, VIM
5heparin44 28 11 2412.8DES, MB
6aspartate449.6ENO2, MDM2
7bezafibrate44 28 1111.6VIM, MB, DES
8s 100449.5DES, VIM, ENO2
9toluidine449.5ENO2, DES, VIM
10hematoxylin449.4DES, VIM, ENO2
11ganglioside449.4DES, ENO2, VIM
12diethylstilbestrol44 28 1111.3MDM2, ABCB1, ENO2
13acnu449.2ABCB1, TP53
1410-hydroxycamptothecin449.2TP53, MDM2
15gefitinib44 49 1111.2VIM, MDM2, ABCB1
16adpribose449.1MDM2, TP53, DES
17bromodeoxyuridine449.1ENO2, DES, VIM
18roscovitine449.0VIM, MDM2, TP53
19hyaluronic acid44 2410.0VIM, ENO2, DES, MB
20mannitol44 1110.0MB, ENO2, ABCB1
21glycogen44 2410.0VIM, MDM2, DES, ENO2
22paclitaxel44 49 1110.9ABCB1, TP53, MDM2
23lactate448.9VIM, MB, DES, ENO2
24irinotecan44 49 1110.9ABCB1, TP53, MDM2
25mitomycin c448.9TP53, MDM2, ABCB1
26estradiol44 11 2410.8VIM, DES, ABCB1, MDM2
27cytarabine44 49 1110.8VIM, TP53, ABCB1
28methotrexate44 49 1110.7ENO2, ABCB1, VIM, MDM2
29proline448.6TP53, MDM2, DES, VIM
30melphalan44 119.6ABCB1, MDM2, MB, TP53
31iron44 249.6VIM, DES, MB, ENO2, MDM2
32adenylate448.5VIM, MB, DES, ENO2
33thymidine44 249.5DES, TP53, MDM2, ENO2
34vinblastine44 49 1110.5ABCB1, MDM2, VIM, TP53
35carboplatin44 49 1110.5TP53, ENO2, ABCB1, MDM2
36vincristine44 49 1110.5MDM2, ABCB1, VIM, TP53
37thymidylate448.5TP53, VIM, MDM2, ABCB1
38docetaxel44 49 59 1111.5TP53, ENO2, ABCB1, MDM2
39h2o2448.3TP53, VIM, MB, MDM2, DES
40camptothecin44 59 1110.3TP53, ABCB1, MDM2
41arginine448.3DES, MDM2, MB, VIM, TP53
42actinomycin d448.1VIM, MDM2, DES, ABCB1, TP53
43cisplatin44 49 59 1111.0ABCB1, MDM2, MB, ENO2, TP53
44testosterone44 59 11 2411.0ABCB1, ENO2, MDM2, MB, VIM, DES
45etoposide44 49 59 1111.0ENO2, TP53, MDM2, VIM, ABCB1
46paraffin447.8MDM2, ENO2, DES, MB, VIM, TP53
47vegf447.8VIM, TP53, DES, ENO2, MDM2, MB
48adriamycin447.7MDM2, DES, ABCB1, MB, TP53, VIM
49doxorubicin44 49 119.7MDM2, MB, TP53, DES, VIM, ABCB1
50progesterone44 59 28 11 2411.6VIM, MDM2, ABCB1, ENO2, TP53, DES

GO Terms for genes affiliated with Orbit Rhabdomyosarcoma

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16Gene Ontology
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Cellular components related to Orbit Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.2TP53, MDM2

Biological processes related to Orbit Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3DES, VIM
2response to antibioticGO:0466779.1TP53, MDM2
3modulation by virus of host morphology or physiologyGO:0190488.7TP53, MDM2, VIM

Molecular functions related to Orbit Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5MDM2, VIM
2identical protein bindingGO:0428028.0TP53, DES, MDM2, VIM

Products for genes affiliated with Orbit Rhabdomyosarcoma

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  • Antibodies
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Sources for Orbit Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet