Aliases & Classifications for Orbital Cancer

MalaCards integrated aliases for Orbital Cancer:

Name: Orbital Cancer 12 14
Orbital Neoplasms 42 69
Malignant Neoplasm of Orbit 12
Neoplasm of Orbit Proper 12
Orbital Tumor 12
Orbit Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4143
ICD10 33 C69.6
ICD9CM 35 190.1
MeSH 42 D009918
NCIt 47 C3290 C3562

Summaries for Orbital Cancer

Disease Ontology : 12 A bone cancer that is located in the area behind the eye and derives from the orbit or secondarily derives from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

MalaCards based summary : Orbital Cancer, also known as orbital neoplasms, is related to cavernous hemangioma and exophthalmos. An important gene associated with Orbital Cancer is NDUFA12 (NADH:Ubiquinone Oxidoreductase Subunit A12), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and b cells.

Related Diseases for Orbital Cancer

Diseases related to Orbital Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 cavernous hemangioma 28.8 ENO2 NCAM1 SYP
2 exophthalmos 11.1
3 intraorbital meningioma 10.9
4 luxation of globe 10.8
5 mixed germ cell tumor of central nervous system 10.5 NDUFA12 NDUFA2
6 ludwig's angina 10.4 NCAM1 SYP
7 neuritis 10.4 NCAM1 SYP
8 hypogonadotropic hypogonadism without anosmia, x-linked 10.4 NCAM1 SYP
9 diffuse lipomatosis 10.4 NCAM1 SYP
10 thyroid sarcoma 10.4 NCAM1 SYP
11 sm-ahnmd 10.4 NCAM1 SYP
12 malignant teratoma 10.4 NCAM1 SYP
13 trachea sarcoma 10.4 NCAM1 SYP
14 arteriosclerosis obliterans 10.3 ENO2 NCAM1
15 verruciform xanthoma of skin 10.3 ENO2 NCAM1
16 testicular malignant germ cell cancer 10.3 ENO2 NCAM1
17 diffuse alopecia areata 10.3 MB SYP
18 uterine benign neoplasm 10.3 MB SYP
19 2q31.1 microdeletion syndrome 10.3 ENO2 SYP
20 rectum lymphoma 10.3 MB SYP
21 benign peritoneal mesothelioma 10.3 NCAM1 SYP
22 biliary dyskinesia 10.3 MB SYP
23 urethral villous adenoma 10.2 ENO2 NCAM1
24 paranasal sinus cancer 10.2 ENO2 SYP
25 ampulla of vater small cell carcinoma 10.2 ENO2 SYP
26 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.2 ENO2 SYP
27 childhood choriocarcinoma of the ovary 10.2 ENO2 SYP
28 osteoblastoma 10.2 ENO2 SYP
29 bronchus adenoma 10.2 ENO2 SYP
30 small intestine cancer, childhood 10.2 ENO2 SYP
31 pemphigus foliaceus 10.2 ENO2 SYP
32 skin papilloma 10.2 ENO2 SYP
33 congenital granular cell tumor 10.2 ENO2 SYP
34 brain glioma 10.2 ENO2 SYP
35 mast cell neoplasm 10.2 ENO2 SYP
36 hair disease 10.2 ENO2 SYP
37 cauda equina intradural extramedullary astrocytoma 10.2 ENO2 SYP
38 rh isoimmunization 10.2 ENO2 SYP
39 cauda equina neoplasm 10.2 ENO2 SYP
40 mature teratoma 10.2 ENO2 SYP
41 axonal neuropathy 10.2 ENO2 SYP
42 childhood choroid plexus cancer 10.2 ENO2 SYP
43 brachial plexus neuritis 10.2 ENO2 SYP
44 malignant granular cell myoblastoma 10.2 ENO2 SYP
45 behcet's syndrome arthropathy 10.2 ENO2 SYP
46 proliferative type fibrocystic change of breast 10.2 ENO2 SYP
47 pineoblastoma 10.2 ENO2 SYP
48 olfactory neural tumor 10.2 ENO2 SYP
49 pituitary dwarfism with large sella turcica 10.2 ENO2 SYP
50 sensory organ benign neoplasm 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Orbital Cancer:



Diseases related to Orbital Cancer

Symptoms & Phenotypes for Orbital Cancer

Drugs & Therapeutics for Orbital Cancer

Drugs for Orbital Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
4 Thiotepa Approved Phase 3,Phase 2 52-24-4 5453
5
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
6
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
7
Lenograstim Approved Phase 3 135968-09-1
8 Antirheumatic Agents Phase 3,Phase 2
9 Alkylating Agents Phase 3,Phase 2
10 Antimitotic Agents Phase 3,Phase 2
11 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
12 Etoposide phosphate Phase 3,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 2
14 Topoisomerase Inhibitors Phase 3,Phase 2
15
Acetylcholine Approved Phase 2 51-84-3 187
16 abobotulinumtoxinA Phase 2
17 Botulinum Toxins Phase 2
18 Botulinum Toxins, Type A Phase 2
19 Cholinergic Agents Phase 2
20 Neuromuscular Agents Phase 2
21 Neurotransmitter Agents Phase 2
22 onabotulinumtoxinA Phase 2
23 Peripheral Nervous System Agents Phase 2
24
rituximab Approved 174722-31-7 10201696
25
Menthol Approved 2216-51-5 16666
26
Iodine Investigational 7553-56-2 807
27 Antibodies
28 Antibodies, Monoclonal
29 Immunoglobulins
30 cadexomer iodine
31 Anesthetics
32 Central Nervous System Depressants

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 VISmodegib for ORbital and Periocular Basal Cell Carcinoma Recruiting NCT02436408 Phase 4 Vismodegib
2 Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Active, not recruiting NCT00554788 Phase 3 cisplatin;cyclophosphamide;etoposide;carboplatin;vincristine sulfate;thiotepa
3 Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
4 Ultra Low Dose 4 Gy Orbital Radiation for Definitive Therapy of Indolent B Cell Lymphoma Recruiting NCT02494700 Phase 2
5 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Recruiting NCT02870907 Phase 2 Etoposide;Vincristine;Carboplatin;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Carboplatin;Thiotepa;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Thiotepa
6 Effectiveness and Possible Complications of Core Needle Biopsy of Orbital Tumors Unknown status NCT01772355
7 Social-Psychological Aspects of Orbital Exenteration Completed NCT00601744
8 Multiparametric Characterization of Orbital Tumors by MRI Completed NCT01884207
9 Radioimmunotherapy With 90Y Zevalin for Orbital Lymphoma Completed NCT00387023 Rituximab;Zevalin
10 Low-dose Radioiodine Ablation in Graves' Disease Completed NCT03110835
11 Reliability of Hertel Exophthalmometer Measurements Completed NCT01691183
12 MRI and Orbital Tumours (MEDORT) Recruiting NCT02401906
13 Postoperative Pain in Orbital Disease and Ocular Tumor Recruiting NCT02704715
14 MRI Perfusion Curves Typology and Orbital Tumors (PERFORM) Enrolling by invitation NCT02434120
15 Ultrasound Exam With Doppler for the Etiological Diagnosis of Orbital Masses (PUCE) Enrolling by invitation NCT02678091
16 Evaluation of Transconjunctival Approach in Management of Orbital Tumors Not yet recruiting NCT03195101

Search NIH Clinical Center for Orbital Cancer

Cochrane evidence based reviews: orbital neoplasms

Genetic Tests for Orbital Cancer

Anatomical Context for Orbital Cancer

MalaCards organs/tissues related to Orbital Cancer:

39
Eye, Bone, B Cells

Publications for Orbital Cancer

Articles related to Orbital Cancer:

id Title Authors Year
1
Orbital cancer: A second cancer in exenterated patients. ( 28812910 )
2017
2
Two-stage rapid exenteration reconstruction to allow early radiation therapy for an aggressive orbital cancer. ( 28474158 )
2017
3
Can the onset of orbital cancer be the result of a prosthetic eye? ( 28530256 )
2017
4
A retrospective analysis of primary eye cancer at the University of Alabama at Birmingham 1958-1988. Part I: Eye and orbital cancer. ( 1813507 )
1991
5
Atypical facial pain and orbital cancer. ( 3985856 )
1985

Variations for Orbital Cancer

Expression for Orbital Cancer

Search GEO for disease gene expression data for Orbital Cancer.

Pathways for Orbital Cancer

Pathways related to Orbital Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 ENO2 NCAM1 SYP
2 10.86 NCAM1 SYP

GO Terms for Orbital Cancer

Cellular components related to Orbital Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 8.96 NDUFA12 NDUFA2
2 mitochondrial respiratory chain complex I GO:0005747 8.62 NDUFA12 NDUFA2

Biological processes related to Orbital Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I assembly GO:0032981 8.96 NDUFA12 NDUFA2
2 mitochondrial electron transport, NADH to ubiquinone GO:0006120 8.62 NDUFA12 NDUFA2

Molecular functions related to Orbital Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.62 NDUFA12 NDUFA2

Sources for Orbital Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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