MCID: ORF002
MIFTS: 34

Orofacial Cleft malady

Categories: Genetic diseases (common), Oral diseases

Aliases & Classifications for Orofacial Cleft

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Aliases & Descriptions for Orofacial Cleft:

Name: Orofacial Cleft 10 12

Classifications:



External Ids:

Disease Ontology10 DOID:0050567

Summaries for Orofacial Cleft

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MalaCards based summary: Orofacial Cleft is related to orofacial cleft 5 and orofacial cleft 11. An important gene associated with Orofacial Cleft is IRF6 (Interferon Regulatory Factor 6), and among its related pathways are TP53 network and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include lung, brain and breast, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Related Diseases for Orofacial Cleft

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Diseases in the Orofacial Cleft family:

Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 6 Orofacial Cleft 10
Orofacial Cleft 5 Orofacial Cleft 4
Orofacial Cleft 12 Orofacial Cleft 9
Orofacial Cleft 11

Diseases related to Orofacial Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1orofacial cleft 512.7
2orofacial cleft 1112.7
3orofacial cleft 612.7
4orofacial cleft 1012.7
5tooth agenesis, selective, 1, with or without orofacial cleft12.7
6orofacial cleft 1312.5
7orofacial cleft 412.5
8orofacial cleft 1212.5
9orofacial cleft 912.5
10orofacial cleft 1412.4
11rapp-hodgkin syndrome12.1
12cleft lip/palate-ectodermal dysplasia syndrome12.0
13cleft lip +/- cleft palate11.7
14microphthalmia, syndromic 611.6
15otofaciocervical syndrome11.4
16microphthalmia, syndromic 1111.4
17otofaciocervical syndrome 211.4
18split-hand/foot malformation 410.5
19split-hand/foot malformation 610.5
20split-hand/foot malformation 510.4
21split-hand/foot malformation 1 with sensorineural hearing loss10.4
22cleft palate, isolated10.4
23facial clefting, oblique, 110.4
24split-hand/foot malformation 310.4
25breast cancer10.2
26melkersson-rosenthal syndrome10.2
27multiple myeloma10.2
28lymphoma10.2
29myeloma10.2
30cervicitis10.2
31neurilemmoma10.2
32tuberculosis10.2
33vasculitis10.2
34lupus erythematosus10.2
35bronchiectasis10.2
36auriculocondylar syndrome 310.2BMP4, IRF6, MSX1, TP63
37visual pathway disease10.2SATB2, TP63
38limb-mammary syndrome10.2SATB2, TP63
39schimke immunoosseous dysplasia10.1IRF6, SATB2
40rheumatoid arthritis10.1
41gastrointestinal stromal tumor10.1
42colorectal cancer10.1
43myocardial infarction10.1
44systemic lupus erythematosus10.1
45hiv-110.1
46prostate cancer10.1
47hepatocellular carcinoma10.1
48coronary artery disease10.1
49esophageal cancer10.1
50hodgkin lymphoma10.1

Graphical network of the top 20 diseases related to Orofacial Cleft:



Diseases related to orofacial cleft

Symptoms for Orofacial Cleft

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Drugs & Therapeutics for Orofacial Cleft

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Drugs for Orofacial Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Hydroxocobalaminapproved22713422-51-011953898, 5460373, 44475014
Synonyms:
13422-51-0
22465-48-1
78091-12-0
8017-22-9
Acti-B12
AlphaRedisol
AlphaRedisol (TN)
Axion
Axlon
Benzimidazolyl ribofuranosyl phosphate deriv.
C08230
C62H85CoN13O15P
CHEBI:27786
CHEMBL1200742
CHEMBL235822
CID11622291
CID11953898
CID5460373
CID6433575
CID6474319
Ciplamin H
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
Cobalex
Cobalin H
Cobinamide dihydroxide dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosylbenzimidazole inner salt
Cobinamide, Co-hydroxy-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobinamide, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Codroxomin
Cyanokit
Cyanokit (TN)
D01027
DB00200
Depogamma
Docclan
Docelan
Docelvita
Docevita
Droxomin
Ducobee Hy
Ducobee-Hy
Duradoce
Duralta-12
EINECS 236-533-2
HSDB 3342
HYDROXOCOBALAMIN
Hidroxocobalamina
Hidroxocobalamina [INN-Spanish]
 
Hydro Cobex
Hydrobamine
Hydrocobalamin
Hydrogrisevit
Hydrovit
Hydroxocobalamin
Hydroxocobalamin (JAN/USP/INN)
Hydroxocobalamin Vitamin B12
Hydroxocobalamin [USAN:INN:BAN:JAN]
Hydroxocobalamin acetate
Hydroxocobalamin monohydrochloride
Hydroxocobalamin(alkaline soln.), OH- replaces CN- in Cyanocobalamin)
Hydroxocobalaminacetat
Hydroxocobalamine
Hydroxocobalamine [INN-French]
Hydroxocobalaminum
Hydroxocobalaminum [INN-Latin]
Hydroxocobemine
Hydroxomin
Hydroxy Cobal
Hydroxy vitamin B12
Hydroxycob(lll)alamin
Hydroxycobalamin
Hydroxycobalamine
Hyxobamine
Idrogrisevit
Idrossocobalamina
Idrossocobalamina [DCIT]
LS-54607
Lyovit-H
Neo-Betalin 12
Neo-cytamen
Neo-macrabin
Neo-rojamin
OH-Cbl
OH-Duphar
Ohb12
Oxobemin
Oxolamine (arcum)
Primabalt RP
Redisol-H
S1668_Selleck
Sytobex-H
UNII-Q40X8H422O
Vibeden
Vitadurin
Vitamin B(sub 12a)
Vitamin B-12b
Vitamin B12a
Vitamin B12b
a-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
alpha Cobione
alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
vitamin B-12b
2
Cyanocobalaminapproved, nutraceutical22768-19-944176380
Synonyms:
Anacobin
Bedoz
Berocca PN
Berubigen
Betalin 12
Betalin 12 Crystalline
Betaline-12
Betolvex
Bevidox
Bevidox concentrate
Biocobalamine
Byladoce
Cabadon m
Cernevit-12
Cobadoce forte
Cobalin
Cobavite
Cobex
Cobolin-M
Copharvit 5000
Covit
Crystamin
Crystamine
Crysti-12
Crystimin
Crystwel
Cyano-B12
Cyanobalamin concentrate
Cyanocob(III)alamin
Cyanocobalamin
Cyanocobalamin (JP15/USP)
Cyanocobalamin Co 57 Schilling Test Kit
Cyanocobalamine
Cyanocobalmin
Cyanoject
Cycobemin
Cycolamin
Cykobemin
Cykobeminet
Cyomin
Cyredin
Cytacon
Cytamen
Cytobion
Depinar
Dicopac
Dicopac Kit
Dimethylbenzimidazoylcobamide
Distivit
Docemine
Docibin
Docivit
Dodecabee
Dodecavite
Dodex
Duodecibin
Embiol
Emociclina
Eritrone
 
Erycytol
Erythrotin
Euhaemon
Extrinsic factor
Factor II
Fermin
Fresmin
Hemomin
Hepagon
Hepavis
Hepcovite
Hylugel plus
Infuvite Pediatric
Lactobacillus lactis dorner factor
M.V.I. Pediatric
Macrabin
Megabion
Megalovel
Milbedoce
Millevit
Nagravon
Nascobal
Nascobal (TN)
Neuroforte-R
Normocytin
Novidroxin
Pernaemon
Pernaevit
Pernipuron
Plecyamin
Poyamin
Primabalt
Rebramin
Redamina
Redisol
Rhodacryst
Rubesol
Rubivite
Rubramin
Rubramin PC
Rubratope-57 Kit
Rubratope-60 Kit
Rubripca
Rubrocitol
Ruvite
Shovite
Sytobex
Vi-Twel
Vibal
Vibalt
Vibisone
Virubra
Vita-rubra
Vitabee 12
Vitamin B12
Vitamin B12 Preparation
Vitamin B12 complex
Vitaped
Vitarubin
Vitral
vitamine b12
3
Folic Acidapproved, nutraceutical292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
4Vitamin B Complex2847
5Vitamin B 12227
6Vitamins3857
7
8Vitamin B12Nutraceutical227
9Folinic AcidNutraceutical2604
10Vitamin B9Nutraceutical2924
11
CobalaminNutraceutical22713408-78-16438156
Synonyms:
5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole
Cob(III)alamin
Cobalamin (III)
Cobalamine
 
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
Hydroxomin
Rubivite
Rubratope-57
Rubratope-60
Ruvite
Vitamin B12
12FolateNutraceutical2924
13
MethylcobalaminNutraceutical22613422-55-4
Synonyms:
Algobaz
Co-Methylcobalamin
Hitocobamin M
MeCbl
Mecobalamin
Methycobal
 
Methyl cobalamine
Methyl vitamin B12
Methyl-5,6-dimethylbenzimidazolylcobalamin
Methyl-B12
Methylcob(III)alamin
Methylcobalamin
Methylcobaz

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish PopulationCompletedNCT00341068
2Influence of Genetics on Vitamin Metabolism in Pregnant WomenCompletedNCT00340366
3Pregnancy Environment and Newborn MalformationsRecruitingNCT01613638

Search NIH Clinical Center for Orofacial Cleft

Genetic Tests for Orofacial Cleft

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Anatomical Context for Orofacial Cleft

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MalaCards organs/tissues related to Orofacial Cleft:

33
Lung, Brain, Breast, Heart, Ovary, B cells, Prostate

Animal Models for Orofacial Cleft or affiliated genes

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MGI Mouse Phenotypes related to Orofacial Cleft:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.4BMP4, IRF6, MSX1, SATB2, TGFB3, TP63
2MP:00053818.9BMP4, IRF6, MSX1, SATB2, SUMO1, TGFB3
3MP:00053828.8BMP4, IRF6, MSX1, NECTIN1, OFCC1, SATB2

Publications for Orofacial Cleft

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Articles related to Orofacial Cleft:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
A Prospective Randomized Study on the Risk of Bacteremia in Banding versus Sclerotherapy of Esophageal Varices. (27200352)
2016
2
Use of a Nitinol Wire Stent for Management of Severe Tracheal Stenosis in an Eclectus Parrot (Eclectus roratus). (26378671)
2015
3
The risk for type B aortic dissection in Marfan syndrome. (26350976)
2015
4
High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. (24685695)
2014
5
Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin. (24848868)
2014
6
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. (24478424)
2014
7
MicroRNA-21 expression is associated with overall survival in patients with glioma. (24326156)
2013
8
Ventilator-associated problems related to obstructive lung disease. (23709193)
2013
9
Curbing our enthusiasm for fecal transplantation in ulcerative colitis. (24091506)
2013
10
Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass. (24107484)
2013
11
Increased membrane turnover in the brain in cutaneous anthrax without central nervous system disorder: a magnetic resonance spectroscopy study. (22543072)
2012
12
Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry. (22953073)
2012
13
FPIN's Clinical Inquiries. Treatment of motion sickness. (22962932)
2012
14
Expression and clinical significance of GRIM-19 in lung cancer. (22573109)
2012
15
Src signaling involvement in Japanese encephalitis virus-induced cytokine production in microglia. (21354239)
2011
16
The Norse god of autophagy. Interviewed by Daniel J Klionsky. (20814236)
2010
17
PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. (19380770)
2009
18
Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes. (19322028)
2009
19
A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients. (18795264)
2009
20
TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. (18184874)
2008
21
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. (18277906)
2008
22
Identification of direct regulatory targets of the transcription factor Sox10 based on function and conservation. (18786246)
2008
23
Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. (17452370)
2007
24
CD26/dipeptidyl peptidase IV as a novel therapeutic target for cancer and immune disorders. (17346218)
2007
25
Relationship between external anal sphincter atrophy at endoanal magnetic resonance imaging and clinical, functional, and anatomic characteristics in patients with fecal incontinence. (16583292)
2006
26
Letrozole : in postmenopausal hormone-responsive early-stage breast cancer. (16526826)
2006
27
Chemotherapy-induced carcinoembryonic antigen surge in patients with metastatic colorectal cancer. (16446549)
2006
28
Pleomorphic lipoma of the face: case report. (16390474)
2006
29
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor. (16682185)
2006
30
CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. (15912538)
2005
31
Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1. (15170387)
2004
32
Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. (15181155)
2004
33
Requirement of KrA1ppel-like factor 4 in preventing entry into mitosis following DNA damage. (14627709)
2004
34
Mutations in the substrate binding site of thrombin-activatable fibrinolysis inhibitor (TAFI) alter its substrate specificity. (12799375)
2003
35
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. (12441104)
2002
36
Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (11401424)
2001
37
Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones. (11606642)
2001
38
One-stage operation for descending thoracic aortic aneurysm and left lung cancer: a case report. (11578266)
2001
39
A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3. (11595190)
2001
40
Immunohistochemical expression of doublecortin in the human cerebrum: comparison of normal development and neuronal migration disorders. (10773210)
2000
41
Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease. (10848666)
2000
42
Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition. (9632711)
1998
43
The expression of drug resistance gene products during the progression of human prostate cancer. (9626455)
1998
44
Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2. (9177791)
1997
45
Mutations in the Chediak-Higashi syndrome gene (CHS1) indicate requirement for the complete 3801 amino acid CHS protein. (9215679)
1997
46
The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. (9382863)
1997
47
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. (8475101)
1993
48
Aortic features in Tangier disease and pathogenetic considerations--Part I. Fatty dots and streaks. (1380464)
1992
49
Crystallization and preliminary X-ray diffraction study of Lathyrus ochrus isolectin II complexed to the human lactotransferrin N2 fragment. (1404396)
1992
50
Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells. (1347254)
1992

Variations for Orofacial Cleft

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Expression for genes affiliated with Orofacial Cleft

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Search GEO for disease gene expression data for Orofacial Cleft.

Pathways for genes affiliated with Orofacial Cleft

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Pathways related to Orofacial Cleft according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.1SUMO1, TP63
29.8BMP4, IRF6, MSX1, TP63

GO Terms for genes affiliated with Orofacial Cleft

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Biological processes related to Orofacial Cleft according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cloacal septationGO:006019710.7BMP4, TP63
2embryonic hindlimb morphogenesisGO:003511610.6BMP4, MSX1
3positive regulation of SMAD protein import into nucleusGO:006039110.6BMP4, TGFB3
4face morphogenesisGO:006032510.5MSX1, TGFB3
5lung alveolus developmentGO:004828610.4BMP4, TGFB3
6odontogenesisGO:004247610.3BMP4, MSX1, TGFB3
7embryonic limb morphogenesisGO:003032610.0BMP4, MSX1, TP63
8anatomical structure formation involved in morphogenesisGO:00486469.9BMP4, TP63
9positive regulation of transcription from RNA polymerase II promoterGO:00459449.4BMP4, NHLH1, SATB2, TGFB3, TP63

Sources for Orofacial Cleft

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet