MCID: ORF002
MIFTS: 39

Orofacial Cleft malady

Categories: Genetic diseases (common), Oral diseases

Aliases & Classifications for Orofacial Cleft

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Aliases & Descriptions for Orofacial Cleft:

Name: Orofacial Cleft 10 12

Classifications:



External Ids:

Disease Ontology10 DOID:0050567

Summaries for Orofacial Cleft

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MalaCards based summary: Orofacial Cleft is related to orofacial cleft 5 and orofacial cleft 11. An important gene associated with Orofacial Cleft is IRF6 (Interferon Regulatory Factor 6), and among its related pathways are TP53 network and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, prostate and breast, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Related Diseases for Orofacial Cleft

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Diseases in the Orofacial Cleft family:

Orofacial Cleft 13 Orofacial Cleft 14
Orofacial Cleft 6 Orofacial Cleft 10
Orofacial Cleft 5 Orofacial Cleft 4
Orofacial Cleft 12 Orofacial Cleft 9
Orofacial Cleft 11

Diseases related to Orofacial Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1orofacial cleft 512.3
2orofacial cleft 1112.3
3orofacial cleft 612.3
4orofacial cleft 1012.3
5tooth agenesis, selective, 1, with or without orofacial cleft12.3
6orofacial cleft 1312.1
7orofacial cleft 412.1
8orofacial cleft 1212.1
9orofacial cleft 912.1
10orofacial cleft 1412.0
11rapp-hodgkin syndrome11.7
12cleft lip/palate-ectodermal dysplasia syndrome11.6
13cleft lip +/- cleft palate11.3
14microphthalmia, syndromic 611.2
15otofaciocervical syndrome11.0
16microphthalmia, syndromic 1111.0
17otofaciocervical syndrome 211.0
18auriculocondylar syndrome 310.3BMP4, IRF6, MSX1, TP63
19visual pathway disease10.3SATB2, TP63
20limb-mammary syndrome10.3SATB2, TP63
21neural tube defects10.2
22schimke immunoosseous dysplasia10.2IRF6, SATB2
23split-hand/foot malformation 410.1
24split-hand/foot malformation 610.1
25tooth agenesis10.1
26cleft lip10.1
27split-hand/foot malformation 510.0
28split-hand/foot malformation 1 with sensorineural hearing loss10.0
29cleft palate, isolated10.0
30facial clefting, oblique, 110.0
31split-hand/foot malformation 310.0
32glaucoma, primary open angle, juvenile-onset, 210.0MSX1, TGFB3
33van der woude syndrome9.8
34obesity9.8
35attention deficit-hyperactivity disorder9.8
36hemangioma9.8
37holoprosencephaly9.8
38acrofacial dysostosis9.8
39microphthalmia9.8
40gastroschisis9.8
41dysostosis9.8
42aortic aneurysm9.8
43cholesteatoma9.8
44learning disability9.8
45hyperhomocysteinemia9.8
46amniotic band syndrome9.8
47eec syndrome9.8
48phace syndrome9.8
49aneurysm9.8
50seizure disorder9.8

Graphical network of the top 20 diseases related to Orofacial Cleft:



Diseases related to orofacial cleft

Symptoms for Orofacial Cleft

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Drugs & Therapeutics for Orofacial Cleft

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Drugs for Orofacial Cleft (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Hydroxocobalaminapproved22713422-51-011953898, 5460373, 44475014
Synonyms:
13422-51-0
22465-48-1
78091-12-0
8017-22-9
Acti-B12
AlphaRedisol
AlphaRedisol (TN)
Axion
Axlon
Benzimidazolyl ribofuranosyl phosphate deriv.
C08230
C62H85CoN13O15P
CHEBI:27786
CHEMBL1200742
CHEMBL235822
CID11622291
CID11953898
CID5460373
CID6433575
CID6474319
Ciplamin H
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
Cobalex
Cobalin H
Cobinamide dihydroxide dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosylbenzimidazole inner salt
Cobinamide, Co-hydroxy-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobinamide, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Codroxomin
Cyanokit
Cyanokit (TN)
D01027
DB00200
Depogamma
Docclan
Docelan
Docelvita
Docevita
Droxomin
Ducobee Hy
Ducobee-Hy
Duradoce
Duralta-12
EINECS 236-533-2
HSDB 3342
HYDROXOCOBALAMIN
Hidroxocobalamina
Hidroxocobalamina [INN-Spanish]
 
Hydro Cobex
Hydrobamine
Hydrocobalamin
Hydrogrisevit
Hydrovit
Hydroxocobalamin
Hydroxocobalamin (JAN/USP/INN)
Hydroxocobalamin Vitamin B12
Hydroxocobalamin [USAN:INN:BAN:JAN]
Hydroxocobalamin acetate
Hydroxocobalamin monohydrochloride
Hydroxocobalamin(alkaline soln.), OH- replaces CN- in Cyanocobalamin)
Hydroxocobalaminacetat
Hydroxocobalamine
Hydroxocobalamine [INN-French]
Hydroxocobalaminum
Hydroxocobalaminum [INN-Latin]
Hydroxocobemine
Hydroxomin
Hydroxy Cobal
Hydroxy vitamin B12
Hydroxycob(lll)alamin
Hydroxycobalamin
Hydroxycobalamine
Hyxobamine
Idrogrisevit
Idrossocobalamina
Idrossocobalamina [DCIT]
LS-54607
Lyovit-H
Neo-Betalin 12
Neo-cytamen
Neo-macrabin
Neo-rojamin
OH-Cbl
OH-Duphar
Ohb12
Oxobemin
Oxolamine (arcum)
Primabalt RP
Redisol-H
S1668_Selleck
Sytobex-H
UNII-Q40X8H422O
Vibeden
Vitadurin
Vitamin B(sub 12a)
Vitamin B-12b
Vitamin B12a
Vitamin B12b
a-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
alpha Cobione
alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
vitamin B-12b
2
Cyanocobalaminapproved, nutraceutical22768-19-944176380
Synonyms:
Anacobin
Bedoz
Berocca PN
Berubigen
Betalin 12
Betalin 12 Crystalline
Betaline-12
Betolvex
Bevidox
Bevidox concentrate
Biocobalamine
Byladoce
Cabadon m
Cernevit-12
Cobadoce forte
Cobalin
Cobavite
Cobex
Cobolin-M
Copharvit 5000
Covit
Crystamin
Crystamine
Crysti-12
Crystimin
Crystwel
Cyano-B12
Cyanobalamin concentrate
Cyanocob(III)alamin
Cyanocobalamin
Cyanocobalamin (JP15/USP)
Cyanocobalamin Co 57 Schilling Test Kit
Cyanocobalamine
Cyanocobalmin
Cyanoject
Cycobemin
Cycolamin
Cykobemin
Cykobeminet
Cyomin
Cyredin
Cytacon
Cytamen
Cytobion
Depinar
Dicopac
Dicopac Kit
Dimethylbenzimidazoylcobamide
Distivit
Docemine
Docibin
Docivit
Dodecabee
Dodecavite
Dodex
Duodecibin
Embiol
Emociclina
Eritrone
 
Erycytol
Erythrotin
Euhaemon
Extrinsic factor
Factor II
Fermin
Fresmin
Hemomin
Hepagon
Hepavis
Hepcovite
Hylugel plus
Infuvite Pediatric
Lactobacillus lactis dorner factor
M.V.I. Pediatric
Macrabin
Megabion
Megalovel
Milbedoce
Millevit
Nagravon
Nascobal
Nascobal (TN)
Neuroforte-R
Normocytin
Novidroxin
Pernaemon
Pernaevit
Pernipuron
Plecyamin
Poyamin
Primabalt
Rebramin
Redamina
Redisol
Rhodacryst
Rubesol
Rubivite
Rubramin
Rubramin PC
Rubratope-57 Kit
Rubratope-60 Kit
Rubripca
Rubrocitol
Ruvite
Shovite
Sytobex
Vi-Twel
Vibal
Vibalt
Vibisone
Virubra
Vita-rubra
Vitabee 12
Vitamin B12
Vitamin B12 Preparation
Vitamin B12 complex
Vitaped
Vitarubin
Vitral
vitamine b12
3
Folic Acidapproved, nutraceutical292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
4Vitamin B Complex2847
5Vitamin B 12227
6Vitamins3857
7
8Vitamin B12Nutraceutical227
9Folinic AcidNutraceutical2604
10Vitamin B9Nutraceutical2924
11
CobalaminNutraceutical22713408-78-16438156
Synonyms:
5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole
Cob(III)alamin
Cobalamin (III)
Cobalamine
 
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
Hydroxomin
Rubivite
Rubratope-57
Rubratope-60
Ruvite
Vitamin B12
12FolateNutraceutical2924
13
MethylcobalaminNutraceutical22613422-55-4
Synonyms:
Algobaz
Co-Methylcobalamin
Hitocobamin M
MeCbl
Mecobalamin
Methycobal
 
Methyl cobalamine
Methyl vitamin B12
Methyl-5,6-dimethylbenzimidazolylcobalamin
Methyl-B12
Methylcob(III)alamin
Methylcobalamin
Methylcobaz

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish PopulationCompletedNCT00341068
2Influence of Genetics on Vitamin Metabolism in Pregnant WomenCompletedNCT00340366
3Pregnancy Environment and Newborn MalformationsRecruitingNCT01613638

Search NIH Clinical Center for Orofacial Cleft

Genetic Tests for Orofacial Cleft

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Anatomical Context for Orofacial Cleft

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MalaCards organs/tissues related to Orofacial Cleft:

33
Brain, Prostate, Breast, Kidney, Heart, Lung, B cells

Animal Models for Orofacial Cleft or affiliated genes

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MGI Mouse Phenotypes related to Orofacial Cleft:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.4BMP4, IRF6, MSX1, SATB2, TGFB3, TP63
2MP:00053818.9BMP4, IRF6, MSX1, SATB2, SUMO1, TGFB3
3MP:00053828.8BMP4, IRF6, MSX1, NECTIN1, OFCC1, SATB2

Publications for Orofacial Cleft

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Articles related to Orofacial Cleft:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies. (27215617)
2016
2
Maternal Supplementary Folate Intake, Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms and the Risk of Orofacial Cleft in Iranian Children. (26140186)
2015
3
Weight Gain Pattern of Infants with Orofacial Cleft on Three Types of Feeding Techniques. (25650232)
2015
4
MTHFD1 gene polymorphisms as risk factors involved in orofacial cleft: an independent case-control study and a meta-analysis. (26221324)
2015
5
Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts. (26561393)
2015
6
Visualization of the fetal lips and palate using a surface rendered oro-palatal (SROP) view in fetuses with normal palate or orofacial cleft lip with or without cleft palate (CLA+P). (26180023)
2015
7
The axis inhibition protein 2 polymorphisms and non-syndromic orofacial clefts susceptibility in a Chinese Han population. (24484320)
2014
8
Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability. (24678003)
2014
9
Socioeconomic influence on orofacial cleft patient care. (25504476)
2014
10
Strong association of variants around FOXE1 and orofacial clefting. (24563486)
2014
11
MicroRNA-17-92, a direct Ap-2I+ transcriptional target, modulates T-box factor activity in orofacial clefting. (24068957)
2013
12
A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. (23935987)
2013
13
Orbital Prosthetic Rehabilitation in "ADAM Complex" Multiple Orofacial-Cleft Disruption Syndrome. (23762737)
2013
14
Early Mother-Child Interaction and Later Quality of Attachment in Infants With an Orofacial Cleft Compared to Infants Without Cleft. (23611443)
2013
15
Pre-operative haematological investigations in paediatric orofacial cleft repair: any relevance to management outcome? (22382105)
2012
16
Van der Woude syndrome- a syndromic form of orofacial clefting. (24558537)
2012
17
Extension of orofacial cleft size and gestational bleeding in early pregnancy. (23565843)
2012
18
Significant evidence of association between polymorphisms in ZNF533, environmental factors, and nonsyndromic orofacial clefts in the Western Han Chinese population. (20849254)
2011
19
Whole blood propionylcarnitine in newborns with orofacial cleft. (21470367)
2011
20
Breakthroughs in the genetics of orofacial clefting. (21885341)
2011
21
Polymorphic variants of genes related to arginine metabolism and the risk of orofacial clefts. (20739017)
2010
22
IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population. (20799332)
2010
23
Lack of association of polymorphic variants of genes encoding zinc transporters with the risk of orofacial cleft-affected pregnancies. (21478106)
2010
24
Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China. (19891592)
2010
25
New insights in collagen turnover in orofacial cleft patients. (20590460)
2010
26
The 18q deletion syndrome and analysis of the critical region for orofacial cleft at 18q22.3. (19157891)
2009
27
Midline orofacial cleft defects in association with type 1 Duane's retraction syndrome. (18691219)
2009
28
The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts. (18932005)
2008
29
Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? (18650491)
2008
30
Spatial distribution of orofacial cleft defect births in Harris County, Texas, 1990 to 1994, and historical evidence for the presence of low-level radioactivity in tap water. (17591309)
2007
31
Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts. (17608547)
2007
32
Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis. (17431894)
2007
33
Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts. (16135950)
2005
34
Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? (15887275)
2005
35
Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts. (16269583)
2005
36
Recent developments in orofacial cleft genetics. (12621282)
2003
37
Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis. (12652527)
2003
38
Amniotic band syndrome with significant orofacial clefts and disruptions and distortions of craniofacial structures. (12677585)
2003
39
Orofacial cleft in Southern Italy. (14765027)
2003
40
Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use. (12397635)
2002
41
Report of a child with aortic aneurysm, orofacial clefting, hemangioma, upper sternal defect, and marfanoid features: possible PHACE syndrome. (12116239)
2002
42
Linkage analysis of candidate endothelin pathway genes in nonsyndromic familial orofacial cleft. (11415518)
2000
43
MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. (10742093)
2000
44
Severe acrofacial dysostosis with orofacial clefting and tetraphocomelia diagnosed in the plaster cast of a 100-year-old anatomical specimen. (9674917)
1998
45
Suggestive linkage between markers on chromosome 19q13.2 and nonsyndromic orofacial cleft malformation. (9722939)
1998
46
Suggestion of linkage of a major locus for nonsyndromic orofacial cleft with F13A and tentative assignment to chromosome 6. (2888553)
1987
47
Incidence of sensory integrative dysfunction among children with orofacial cleft. (7223831)
1981
48
The incidence of sensory integrative dysfunction among children with orofacial cleft. (7267664)
1980
49
The incidence of sensory integrative dysfunction among children with orofacial cleft: a critique. (7267665)
1980
50
Seizure disorder in mothers of children with orofacial clefts: a case-control study. (4810733)
1974

Variations for Orofacial Cleft

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Expression for genes affiliated with Orofacial Cleft

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Search GEO for disease gene expression data for Orofacial Cleft.

Pathways for genes affiliated with Orofacial Cleft

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Pathways related to Orofacial Cleft according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.1SUMO1, TP63
29.8BMP4, IRF6, MSX1, TP63

GO Terms for genes affiliated with Orofacial Cleft

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Biological processes related to Orofacial Cleft according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cloacal septationGO:006019710.7BMP4, TP63
2embryonic hindlimb morphogenesisGO:003511610.6BMP4, MSX1
3positive regulation of SMAD protein import into nucleusGO:006039110.6BMP4, TGFB3
4face morphogenesisGO:006032510.5MSX1, TGFB3
5lung alveolus developmentGO:004828610.4BMP4, TGFB3
6odontogenesisGO:004247610.3BMP4, MSX1, TGFB3
7embryonic limb morphogenesisGO:003032610.0BMP4, MSX1, TP63
8anatomical structure formation involved in morphogenesisGO:00486469.9BMP4, TP63
9positive regulation of transcription from RNA polymerase II promoterGO:00459449.4BMP4, NHLH1, SATB2, TGFB3, TP63

Sources for Orofacial Cleft

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet