MCID: ORT004
MIFTS: 48

Orthostatic Intolerance malady

Summaries for Orthostatic Intolerance

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Orthostatic intolerance (OI) is the development of symptoms when standing upright which are relieved... more...

MalaCards: Orthostatic Intolerance, also known as mitral valve prolapse syndrome, is related to chronic fatigue syndrome and mitral valve prolapse. An important gene associated with Orthostatic Intolerance is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Integrin alphaIIb beta3 signaling and Regulation of Water Balance by Renal Aquaporins. The compounds rx821002 and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Description from OMIM:47 604715

Aliases & Classifications for Orthostatic Intolerance

Sources:
47OMIM, 61UMLS
See all sources

Aliases & Descriptions:

orthostatic intolerance 47
mitral valve prolapse syndrome 61


Related Diseases for Orthostatic Intolerance

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Orthostatic Intolerance family:

chronic orthostatic intolerance

Diseases related to Orthostatic Intolerance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.0POMC
2mitral valve prolapse11.0
3chronic orthostatic intolerance10.9
4syncope10.7
5postural orthostatic tachycardia syndrome10.6
6neurocirculatory asthenia10.5
7autonomic dysfunction10.4
8young syndrome10.4
9n syndrome10.3
10dysautonomia10.3
11agoraphobia10.3
12panic disorder10.3
13adult syndrome10.3
14tietze's syndrome10.3
15char syndrome10.3
16tietz syndrome10.3
17mitral valve prolapse, familial, x-linked10.3
18chaotic atrial tachycardia10.3
19left ventricular outflow tract obstruction10.3
20familial mitral valve prolapse10.3
21marfan syndrome10.1
22sudden infant death syndrome10.1
23ehlers–danlos syndrome10.1
24multifocal motor neuropathy10.1
25small fiber neuropathy10.1
26chronic pain10.1
27fainting10.1
28headache10.1
29postural hypotension10.1
30spinal cord injury10.1
31fibromyalgia10.1
32neuroblastoma10.0SLC6A2
33pulmonary disease, chronic obstructive10.0ADRB2
34polycystic ovary syndrome10.0POMC
35thyroiditis10.0POMC
36down syndrome10.0ACHE
37nephrotic syndrome10.0POMC
38dementia10.0ACHE
39vitiligo10.0POMC
40prion disease10.0POMC
41hypothyroidism10.0POMC
42growth hormone deficiency10.0POMC
43adrenocortical carcinoma10.0POMC
44hirschsprung's disease10.0ECE1
45thromboembolism10.0NOS3
46anorexia nervosa10.0SLC6A2, POMC
47pulmonary fibrosis10.0EDN1
48acromegaly10.0POMC
49intracranial aneurysm10.0NOS3
50spina bifida10.0NAT1

Graphical network of the top 20 diseases related to Orthostatic Intolerance:



Diseases related to orthostatic intolerance

Clinical Features for Orthostatic Intolerance

Sources:
47OMIM
See all sources

Clinical features from OMIM:

604715

Drugs & Therapeutics for Orthostatic Intolerance

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Orthostatic Intolerance

Drug clinical trials:

Search ClinicalTrials for Orthostatic Intolerance

Search NIH Clinical Center for Orthostatic Intolerance

Search CenterWatch for Orthostatic Intolerance

Genetic Tests for Orthostatic Intolerance

Anatomical Context for Orthostatic Intolerance

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Orthostatic Intolerance:

33
Brain, Spinal cord, Heart, Tonsil, Endothelial, Temporal lobe

Animal Models for Orthostatic Intolerance or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Orthostatic Intolerance

Sources:
51PubMed
See all sources

Articles related to Orthostatic Intolerance:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Orthostatic intolerance ambulation in patients using patient controlled analgesia. (23862002)
2013
2
Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial. (23756453)
2013
3
Tilt angles and positive response of head-up tilt test in children with orthostatic intolerance. (24124665)
2013
4
Orthostatic intolerance: postural orthostatic tachycardia syndrome with overlapping vasovagal syncope. (22920009)
2012
5
Deconditioning in patients with orthostatic intolerance. (22993288)
2012
6
Temporal artery flow response during the last minute of a head up tilt test, in relation with orthostatic intolerance after a 60 day head-down bedrest. (22073117)
2011
7
Impairment of cerebral blood flow regulation in astronauts with orthostatic intolerance after flight. (21617145)
2011
8
Short duration head-up tilt test: a comparison with conventional long protocol in patients of orthostatic intolerance. (22455267)
2010
9
Effect of thigh cuffs on haemodynamic changes of the middle cerebral artery and on orthostatic intolerance induced by 10 days head-down bed rest. (18565193)
2008
10
Sympathetic reserve, serum potassium, and orthostatic intolerance after endurance exercise and implications for neurocardiogenic syncope. (18480094)
2008
11
Mechanisms of orthostatic intolerance following very prolonged exercise. (18483169)
2008
12
All that shine is not gold: modelling the true relation between orthostatic intolerance, fibromyalgia and chronic fatigue syndromes. (18932009)
2008
13
Insufficient flow reduction during LBNP in both splanchnic and lower limb areas is associated with orthostatic intolerance after bedrest. (18757480)
2008
14
Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome. (17263876)
2007
15
Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance. (15719258)
2005
16
Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome. (15379740)
2004
17
Role of individual predisposition in orthostatic intolerance before and after simulated microgravity. (15075309)
2004
18
Orthostatic intolerance: potential pathophysiology and therapy. (15612527)
2004
19
Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance. (15113425)
2004
20
Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance. (12460877)
2002
21
Mutual information detects a decreased interdependence between RR and SAP in orthostatic intolerance after microgravity condition. (15002504)
2002
22
Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. (12133874)
2002
23
Syncope resulting from autonomic insufficiency syndromes associated with orthostatic intolerance. (11233955)
2001
24
Cerebral autoregulation in orthostatic intolerance. (11458706)
2001
25
Inappropriate early hypotension in adolescents: a form of chronic orthostatic intolerance with defective dependent vasoconstriction. (11420425)
2001
26
Cerebrovascular and cardiovascular responses associated with orthostatic intolerance and tachycardia. (11503949)
2001
27
Marked exacerbation of orthostatic intolerance after long- vs. short-duration spaceflight in veteran astronauts. (11719623)
2001
28
Midodrine prevents orthostatic intolerance associated with simulated spaceflight. (11356789)
2001
29
Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team. (11200979)
2000
30
Upregulation of NOS by simulated microgravity, potential cause of orthostatic intolerance. (10904069)
2000
31
Arterial baroreflex control of sympathetic vasoconstrictor traffic and orthostatic intolerance after head-down bed rest. (12697515)
2000
32
Perioperative considerations in a patient with orthostatic intolerance syndrome. (10910484)
2000
33
Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. (10684912)
2000
34
The importance of orthostatic intolerance in the chronic fatigue syndrome. (10037115)
1999
35
Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. (10516248)
1999
36
Clinical disorders of the autonomic nervous system associated with orthostatic intolerance: an overview of classification, clinical evaluation, and management. (10353141)
1999
37
Contributory factors to orthostatic intolerance after simulated weightlessness. (10516886)
1999
38
Ethanol ingestion prolongs orthostatic intolerance in hyperthermic humans. (9641404)
1998
39
Chronic orthostatic intolerance: part of a spectrum of dysfunction in orthostatic cardiovascular homeostasis? (9815863)
1998
40
Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular system. (9795146)
1998
41
Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. (9815870)
1998
42
Cardiovascular echographic and Doppler parameters for the assessment of orthostatic intolerance. (9614291)
1998
43
Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. (9244220)
1997
44
Beta-blockade does not improve orthostatic intolerance induced by 20 days bed rest. (11541180)
1997
45
The effects of the noradrenaline precursor, L-threo-3,4-dihydroxyphenylserine, in children with orthostatic intolerance. (8902314)
1996
46
Autogenic-feedback training: a potential treatment for orthostatic intolerance in aerospace crews. (8083391)
1994
47
Computer simulation analysis of the effects of countermeasures for reentry orthostatic intolerance. (1589489)
1992
48
Cardiovascular deconditioning during weightlessness simulation and the use of lower body negative pressure as a countermeasure to orthostatic intolerance. (11537546)
1990
49
Aerobic fitness does not contribute to prediction of orthostatic intolerance. (3773672)
1986
50
Orthostatic intolerance after artificial heat acclimatization in physically fit subjects. (5770532)
1969

Genetic Variations for Orthostatic Intolerance

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Orthostatic Intolerance:

63
id Symbol AA change Variation SNP ID
1SLC6A2p.Ala457ProVAR_010022

Expression for genes affiliated with Orthostatic Intolerance

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Orthostatic Intolerance

Search GEO for disease gene expression data for Orthostatic Intolerance.

Pathways for genes affiliated with Orthostatic Intolerance

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG
See all sources

Pathways related to Orthostatic Intolerance according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6ADRA2C, ADRA2B, ADRA2A
2
Hide members
9.6ADRA2A, ADRA2B, ADRA2C
39.5ADRA2A, ADRB1, ADRB2
4
Hide members
9.4NOS3, REN
5
Hide members
9.2ADRA2A, ADRB1, ADRB2, ADRA2C
6
Hide members
9.2ADRA2A, ADRB1, ADRA2B, ADRB2
7
Hide members
9.2ACHE, REN, POMC
8
Hide members
9.1NOS2, NOS3
9
NO-dependent CFTR activation (normal and CF)
9.1NOS2, NOS3
109.1NOS3, ADRA2A, ADRA2B, ADRA2C
11
Hide members
8.7ADRA2C, ADRB2, ADRA2B, ADRB1, ADRA2A, SLC6A2
128.6EDN1, ECE1, NOS3, ADRB1
13
Hide members
8.6EDN1, ADRA2A, ADRB1, ADRA2B, ADRB2
148.5NOS2, NOS3, EDN1
158.4NOS3, NOS2, ADRB1, ADRB2
16
Hide members
8.4NOS3, ADRA2A, ADRB1, ADRA2B, ADRB2, ADRA2C
17
Hide members
8.3NOS3, NOS2, ADRA2A, ADRA2B, ADRA2C
18
Hide members
8.1EDN1, POMC, ADRA2A, ADRB1, ADRA2B, ADRB2
19
Hide members
8.0NAT1, NOS3, NOS2, ACHE, ADRA2A, ADRA2C
20
Hide members
7.6EDN1, NET1, POMC, ADRA2A, ADRB1, ADRA2B

Compounds for genes affiliated with Orthostatic Intolerance

Sources:
29IUPHAR, 60Tocris Bioscience, 11DrugBank, 45Novoseek, 50PharmGKB, 24HMDB
See all sources

Compounds related to Orthostatic Intolerance according to GeneCards/GeneDecks:

(show top 50)    (show all 214)
idCompoundScoreTop Affiliating Genes
1rx8210022910.0ADRA2B, ADRA2C, ADRA2A
2[3h]rx8210022910.0ADRA2A, ADRA2B, ADRA2C
3arc-2392910.0ADRA2C, ADRA2B, ADRA2A
4brl 444082910.0ADRA2C, ADRA2B, ADRA2A
5[3h]mk-9122910.0ADRA2A, ADRA2C, ADRA2B
6brl 44408 maleate6010.0ADRA2B, ADRA2C, ADRA2A
7dexmedetomidine hydrochloride6010.0ADRA2C, ADRA2B, ADRA2A
8atipamezole hydrochloride6010.0ADRA2C, ADRA2B, ADRA2A
9jp 1302 dihydrochloride6010.0ADRA2C, ADRA2B, ADRA2A
10medetomidine hydrochloride6010.0ADRA2A, ADRA2B, ADRA2C
11Bethanidine1110.0ADRA2C, ADRA2B, ADRA2A
12xylazine29 4510.9ADRA2C, ADRA2A, ADRA2B
13[3h]rauwolscine299.9ADRA2B, ADRA2A, ADRA2C
14(±)-adrenaline299.9ADRA2C, ADRA2B, ADRB1
15tizanidine45 1110.9ADRA2C, ADRA2A, ADRA2B
16wb 4101299.8ADRA2C, ADRA2A, ADRA2B
17guanfacine29 45 1111.8ADRA2C, ADRA2B, ADRA2A
18Xylometazoline119.8ADRA2A, ADRA2B, ADRA2C
19doxepin45 29 50 1112.7ADRA2A, SLC6A2, ADRA2B, ADRA2C
20Dronedarone119.7ADRA2A, ADRB1, ADRA2B, ADRA2C
21(-)-noradrenaline299.7ADRA2A, ADRA2C, ADRA2B
22pseudoephedrine45 11 2411.7ADRB1, ADRA2A, ADRB2, SLC6A2
23phenoxybenzamine45 1110.7ADRA2B, ADRA2C, ADRB2, ADRA2A
24prazosin45 29 50 1112.6ADRB1, ADRA2C, ADRA2B, ADRA2A
25rauwolscine299.5ADRA2A, ADRA2C, ADRA2B
26fenoldopam45 1110.5REN, ADRA2A, ADRA2B, ADRA2C
27labetalol45 1110.4REN, ADRB2, ADRB1
28isoproterenol45 1110.4NOS2, ADRB1, ADRA2A
29bucindolol50 4510.4ADRA2C, ADRB2, ADRB1, REN
30asenapine29 1110.4ADRB1, ADRA2A, ADRB2, ADRA2C, ADRA2B
31Droxidopa119.2ADRB1, ADRA2C, ADRB2, ADRA2B, ADRA2A, SLC6A2
32Ephedra119.1ADRA2C, ADRA2B, ADRB1, ADRA2A, SLC6A2, ADRB2
33metoprolol45 29 50 11 2413.1REN, NOS3, ADRB1, ADRB2
34clozapine45 29 50 1112.1POMC, ADRA2A, ADRA2B, ADRB2, ADRA2C
35muraglitazar50 4510.1ADRB1, EDN1, REN
36norepinephrine45 11 2411.1ADRB1, ADRA2C, ADRA2B, SLC6A2, POMC, ADRA2A
37dopamine45 29 11 2411.9ADRB1, ADRB2, ADRA2A, SLC6A2, REN, ADRA2C
38carvedilol45 50 29 1111.5ADRB2, ADRB1, EDN1, NOS3, REN
39n(g),n(g)-dimethylarginine458.5NOS2, EDN1, NOS3
40catecholamine458.4REN, ADRA2C, ADRA2A, POMC, ADRB1, ADRB2
41nebivolol45 119.3ADRB2, ADRB1, NOS2, NOS3, EDN1
42clonidine45 29 1110.3ADRA2B, POMC, REN, NOS3, ADRA2C, ADRA2A
43epinephrine45 11 249.8EDN1, ADRA2B, POMC, REN, SLC6A2, ADRA2A
44cgmp45 298.8NOS2, REN, SLC6A2, NOS3, EDN1
45nitroglycerin45 118.7REN, NOS2, NOS3, EDN1
46phenylephrine45 29 11 2410.6ADRA2B, ADRB1, ADRA2A, NOS2, NOS3, POMC
47glutamate457.5NOS3, SLC6A2, NOS2, ACHE, ADRA2A, ADRA2B
48acetylcholine45 50 29 11 2411.5ADRB2, EDN1, POMC, ACHE, SLC6A2, NOS2
49indomethacin45 60 29 1110.4ECE1, NOS2, NOS3, REN, EDN1, POMC
50nitric oxide45 11 248.9ADRB1, ADRB2, NOS3, NOS2, REN, ECE1

GO Terms for genes affiliated with Orthostatic Intolerance

Sources:
16Gene Ontology
See all sources

Cellular components related to Orthostatic Intolerance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.4ECE1, ADRB2, ADRA2C
2integral to plasma membraneGO:0058878.4ADRA2B, ADRB1, ADRA2A, ADRB2, ADRA2C, SLC6A2
3plasma membraneGO:0058866.8NOS3, ECE1, REN, SLC6A2, ACHE, ADRA2A

Biological processes related to Orthostatic Intolerance according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:07047310.3ADRA2C, ADRA2A
2fear responseGO:04259610.2ADRA2A, ADRB1
3heat generationGO:03164910.1ADRB1, ADRB2
4vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.1ADRB1, ADRB2
5negative regulation of smooth muscle contractionGO:04598610.1ADRB1, ADRB2
6diet induced thermogenesisGO:00202410.1ADRB2, ADRB1
7activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.0ADRA2C, ADRA2B, ADRA2A
8epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.0ADRA2A, ADRA2B, ADRA2C
9negative regulation of epinephrine secretionGO:03281110.0ADRA2A, ADRA2B, ADRA2C
10negative regulation of norepinephrine secretionGO:01070010.0ADRA2C, ADRA2B, ADRA2A
11activation of protein kinase B activityGO:03214810.0ADRA2C, ADRA2B, ADRA2A
12negative regulation of multicellular organism growthGO:0400159.9ADRB1, ADRB2
13female pregnancyGO:0075659.9ADRA2C, ADRA2B, ADRA2A
14negative regulation of calcium ion transportGO:0519269.8ADRA2A, NOS3
15negative regulation of cAMP biosynthetic processGO:0308189.7ADRA2A, EDN1
16regulation of sensory perception of painGO:0519309.6ADRA2C, EDN1
17regulation of sodium ion transportGO:0020289.6ADRB2, NOS3
18regulation of vasoconstrictionGO:0192299.5EDN1, ECE1, ADRA2A
19positive regulation of guanylate cyclase activityGO:0312849.5NOS3, NOS2
20arginine catabolic processGO:0065279.4NOS3, NOS2
21peptide hormone processingGO:0164869.3ECE1, POMC
22regulation of insulin secretionGO:0507969.3ADRA2C, ADRA2A, NOS2
23regulation of systemic arterial blood pressure by endothelinGO:0031009.3NOS3, ECE1, EDN1
24regulation of blood pressureGO:0082179.3NOS3, REN, POMC
25G-protein coupled receptor signaling pathwayGO:0071869.2EDN1, ADRA2A, ADRA2B, ADRA2C
26nitric oxide biosynthetic processGO:0068099.2NOS3, NOS2
27positive regulation of vasodilationGO:0459099.2ADRA2A, NOS2, NOS3
28cell-cell signalingGO:0072679.1EDN1, POMC, ADRA2B, ADRA2C
29nitric oxide mediated signal transductionGO:0072639.0NOS3, NOS2
30blood coagulationGO:0075968.6ADRA2C, ADRA2B, ADRA2A, NOS2, NOS3

Molecular functions related to Orthostatic Intolerance according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1alpha2-adrenergic receptor activityGO:0049389.8ADRA2A, ADRA2B, ADRA2C
2alpha-2A adrenergic receptor bindingGO:0316949.8ADRA2C, ADRB1
3norepinephrine bindingGO:0513809.7ADRB2, ADRB1, ADRA2A
4epinephrine bindingGO:0513799.5ADRA2C, ADRA2B, ADRB1, ADRA2A
5nitric-oxide synthase activityGO:0045179.2NOS2, NOS3
6arginine bindingGO:0346189.2NOS3, NOS2
7tetrahydrobiopterin bindingGO:0346179.1NOS3, NOS2
8FMN bindingGO:0101819.1NOS2, NOS3
9NADPH-hemoprotein reductase activityGO:0039588.8NOS2, NOS3
10protein homodimerization activityGO:0428038.1ECE1, NOS2, ACHE, ADRA2A, ADRB2, ADRA2C

Products for genes affiliated with Orthostatic Intolerance

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Orthostatic Intolerance

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet