MCID: ORT004
MIFTS: 59

Orthostatic Intolerance malady

Genetic diseases (common), Neuronal diseases, Cardiovascular diseases, Mental diseases categories

Aliases & Classifications for Orthostatic Intolerance

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Orthostatic Intolerance, Aliases & Descriptions:

Name: Orthostatic Intolerance 45 10
Mitral Valve Prolapse 9 11 43 32
Neurocirculatory Asthenia 9 11 60
Cardiovascular Malfunction Arising from Mental Factors 9
Mitral Valve Prolapse Syndrome 60
 
Cardiovascular Neurosis 9
Krishaber's Disease 9
Da Costa's Syndrome 9
Floppy Mitral Valve 9
Barlow's Syndrome 9


Classifications:



Summaries for Orthostatic Intolerance

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MedlinePlus:32 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards based summary: Orthostatic Intolerance, also known as mitral valve prolapse, is related to panic disorder and myocarditis, and has symptoms including autosomal dominant inheritanceand orthostatic tachycardia. An important gene associated with Orthostatic Intolerance is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Monoamine Transport and Development Dopamine D2 receptor transactivation of EGFR. The compounds rx821002 and medetomidine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are embryogenesis and vision/eye.

Disease Ontology:9 A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole.

Wikipedia:63 Orthostatic intolerance (OI) is the development of symptoms when standing upright which are relieved... more...

Description from OMIM:45 604715

Related Diseases for Orthostatic Intolerance

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Diseases in the Orthostatic Intolerance family:

Chronic Orthostatic Intolerance

Diseases related to Orthostatic Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.2SLC6A2, POMC
2myocarditis30.9ADRB1, NOS2
3coronary artery disease30.2EDN1, ADRB1, ADRB2, NOS3
4ischemia30.2SLC6A2, NOS2, ADRB2, EDN1, ECE1, NOS3
5mood disorder30.2SLC6A2, ADRA2A, NOS3, POMC, ADRB2
6pulmonary hypertension30.1EDN1, NOS3, NOS2, ECE1
7asthma30.0ECE1, POMC, EDN1, NOS2, ADRB2
8obesity30.0ADRB1, ADRB2, POMC, SLC6A2, NOS3, ADRA2A
9endocarditis10.8
10syncope10.8
11aneurysm10.8
12chronic orthostatic intolerance10.7
13atrial septal aneurysm10.7
14mitral valve prolapse, myxomatous 210.7
15mitral valve prolapse, myxomatous 310.7
16mitral valve prolapse, familial, autosomal dominant10.7
17chronic fatigue syndrome10.7
18cerebritis10.6
19infective endocarditis10.6
20mitral valve prolapse, familial, x-linked10.6
21atrial fibrillation10.5
22hypogonadism mitral valve prolapse mental retardation10.5
23hypogonadism - mitral valve prolapse - intellectual disability10.5
24postural orthostatic tachycardia syndrome10.5
25autonomic dysfunction10.5
26congestive heart failure10.5REN
27acute adrenal insufficiency10.5POMC
28mass syndrome10.5
29migraine10.5
30contractural arachnodactyly, congenital10.5
31keratoconus10.5
32rheumatic heart disease10.5
33hypertrophic cardiomyopathy10.5
34hypermobility syndrome10.5
35stickler syndrome10.5
36anxiety disorder10.5
37thyroiditis10.5
38gastroschisis10.5ACHE
39gitelman syndrome10.4REN
40systemic lupus erythematosus10.4
41williams-beuren syndrome10.4
42costello syndrome10.4
43stickler syndrome, type i10.4
44pseudoxanthoma elasticum10.4
45frontometaphyseal dysplasia10.4
46cardiac valvular dysplasia, x-linked10.4
47ehlers-danlos syndrome, type iv10.4
48shprintzen-goldberg syndrome10.4
49progressive external ophthalmoplegia, autosomal recessive10.4
50fragile x syndrome10.4

Graphical network of the top 20 diseases related to Orthostatic Intolerance:



Diseases related to orthostatic intolerance

Symptoms for Orthostatic Intolerance

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Clinical features from OMIM:

604715

HPO human phenotypes related to Orthostatic Intolerance:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 orthostatic tachycardia HP:0012173

Drugs & Therapeutics for Orthostatic Intolerance

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Drug clinical trials:

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Genetic Tests for Orthostatic Intolerance

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Anatomical Context for Orthostatic Intolerance

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MalaCards organs/tissues related to Orthostatic Intolerance:

31
Heart, Lung, Testes, Brain, Spinal cord, Tonsil, Endothelial

Animal Models for Orthostatic Intolerance or affiliated genes

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Publications for Orthostatic Intolerance

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Articles related to Orthostatic Intolerance:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Orthostatic intolerance predicts mild cognitive impairment: incidence of mild cognitive impairment and dementia from the Swedish general population cohort Good Aging in SkAYne. (25429211)
2014
2
Prognostic analysis of orthostatic intolerance using survival model in children. (25382320)
2014
3
Orthostatic intolerance ambulation in patients using patient controlled analgesia. (23862002)
2013
4
Common syndromes of orthostatic intolerance. (23569093)
2013
5
Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial. (23756453)
2013
6
Syncope and orthostatic intolerance increase risk of brain lesions in migraineurs and controls. (23616159)
2013
7
Orthostatic intolerance: postural orthostatic tachycardia syndrome with overlapping vasovagal syncope. (22920009)
2012
8
Orthostatic intolerance in multifocal acquired demyelinating sensory and motor neuropathy. (22922580)
2012
9
Temporal artery flow response during the last minute of a head up tilt test, in relation with orthostatic intolerance after a 60 day head-down bedrest. (22073117)
2011
10
Gradient compression garments as a countermeasure to post-spaceflight orthostatic intolerance. (20824997)
2010
11
Physiologic neurocirculatory patterns in the head-up tilt test in children with orthostatic intolerance. (18353058)
2008
12
Effect of thigh cuffs on haemodynamic changes of the middle cerebral artery and on orthostatic intolerance induced by 10 days head-down bed rest. (18565193)
2008
13
Is fatigue in Marfan syndrome related to orthostatic intolerance? (18575928)
2008
14
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
15
Treatment of chronic fatigue and orthostatic intolerance with propranolol. (17517256)
2007
16
Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome. (17263876)
2007
17
Acetylcholinesterase inhibition in patients with orthostatic intolerance. (17016160)
2006
18
Orthostatic intolerance and the biopsychosocial model. (15795587)
2005
19
Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS). (15580191)
2004
20
Head-down bed rest reduces the breathing rate short-term variability in subjects with orthostatic intolerance. (16235432)
2004
21
Neuroendocrine changes involved in the genesis of HD-induced orthostatic intolerance. (16231457)
2004
22
A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. (12805287)
2003
23
Nitric oxide in microgravity-induced orthostatic intolerance: relevance to spinal cord injury. (12830962)
2003
24
Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance. (12460877)
2002
25
Mutual information detects a decreased interdependence between RR and SAP in orthostatic intolerance after microgravity condition. (15002504)
2002
26
Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance. (11804991)
2002
27
Therapeutic strategies for orthostatic intolerance: mechanisms, observations, and making patients feel better. (11904120)
2002
28
Doppler measurement of cerebral and lower limb flow during a lower body negative pressure test for predicting orthostatic intolerance. (11758026)
2001
29
Syncope resulting from autonomic insufficiency syndromes associated with orthostatic intolerance. (11233955)
2001
30
Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. (11007589)
2000
31
Orthostatic intolerance: a disorder of young women. (10758621)
2000
32
Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone. (11198485)
2000
33
Leg venous compliance in orthostatic intolerance before and after 14-day head-down bed rest. (11758569)
2000
34
Cardiovascular peripheral effector mechanism in postflight orthostatic intolerance: a simulation study. (12697528)
2000
35
Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team. (11200979)
2000
36
The epidemic of orthostatic tachycardia and orthostatic intolerance. (10037110)
1999
37
Assessment of capillary fluid shifts during orthostatic stress in normal subjects and subjects with orthostatic intolerance. (10225610)
1999
38
Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome. (10518084)
1999
39
Ethanol ingestion prolongs orthostatic intolerance in hyperthermic humans. (9641404)
1998
40
Orthostatic intolerance, blood pressure and its variability. (9794139)
1998
41
Exercise training in orthostatic intolerance. (10024932)
1998
42
Hypovolemia in syncope and orthostatic intolerance role of the renin-angiotensin system. (9274896)
1997
43
Orthostatic intolerance and orthostatic tachycardia: a heterogeneous disorder. (7780285)
1995
44
Mechanisms of post-flight orthostatic intolerance. (11538739)
1994
45
Mechanisms of vasovagal syncope: relevance to postflight orthostatic intolerance. (8089257)
1994
46
Individual differences of cerebrovascular responses to gravitational stress--prediction of orthostatic intolerance. (11539530)
1994
47
Delayed orthostatic intolerance. (1580710)
1992
48
Initial and delayed circulatory responses to orthostatic stress in normal humans and in subjects with orthostatic intolerance. (1387890)
1992
49
Orthostatic intolerance in 6 degrees head-down tilt and lower body negative pressure loading. (11537576)
1992
50
Cardiovascular deconditioning during weightlessness simulation and the use of lower body negative pressure as a countermeasure to orthostatic intolerance. (11537546)
1990

Variations for Orthostatic Intolerance

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UniProtKB/Swiss-Prot genetic disease variations for Orthostatic Intolerance:

62
id Symbol AA change Variation ID SNP ID
1SLC6A2p.Ala457ProVAR_010022

Clinvar genetic disease variations for Orthostatic Intolerance:

6
id Gene Variation Type Significance SNP ID Assembly Location
1SLC6A2NM_001172504.1(SLC6A2): c.1369G> C (p.Ala457Pro)single nucleotide variantPathogenicrs121918126GRCh37Chr 16, 55731917: 55731917

Expression for genes affiliated with Orthostatic Intolerance

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Search GEO for disease gene expression data for Orthostatic Intolerance.

Pathways for genes affiliated with Orthostatic Intolerance

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Pathways related to Orthostatic Intolerance according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity36
9.9SLC6A2, ACHE
2
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.6ADRA2C, ADRA2A, ADRA2B
3
Show member pathways
9.6ADRA2C, ADRA2A, ADRA2B
49.5ADRB1, ADRA2A, ADRB2
5
Show member pathways
9.4NOS3, REN
6
Show member pathways
9.4EDN1, POMC
79.3POMC, ADRB1, ADRB2
8
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.3NOS3, ADRB2, ADRB1
9
Show member pathways
9.2POMC, REN, ACHE
109.1NOS3, NOS2
11
Show member pathways
9.1NOS2, NOS3
12
Show member pathways
9.1NOS2, NOS3
139.1NOS2, NOS3
14
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis36
9.1NOS3, NOS2
15
Show member pathways
9.1ADRA2B, ADRA2A, ADRA2C, NOS3
169.1NOS3, POMC, ECE1
17
Show member pathways
8.9ADRB1, ADRA2B, ADRA2A, ADRA2C, ADRB2
18
Show member pathways
8.8POMC, ADRA2B, ADRA2A, ADRA2C, ADRB2
198.7SLC6A2, ADRB2, ADRA2C, ADRA2A, ADRA2B, ADRB1
208.6NOS3, ADRB1, ECE1, EDN1
21
Show member pathways
8.6EDN1, ADRB1, ADRA2B, ADRA2A, ADRB2
228.5EDN1, NOS2, NOS3
238.4ADRB1, ADRB2, NOS2, NOS3
24
Show member pathways
8.4ADRB1, ADRA2B, ADRA2A, ADRA2C, ADRB2, NOS3
25
Show member pathways
8.3NOS3, NOS2, ADRA2C, ADRA2A, ADRA2B
26
Show member pathways
7.9EDN1, POMC, ADRB1, ADRA2B, ADRA2A, ADRA2C
27
Show member pathways
7.6EDN1, POMC, NET1, ADRB1, ADRA2B, ADRA2A
28
Show member pathways
7.5POMC, NAT1, ADRA2A, ADRA2C, ACHE, NOS2

Compounds for genes affiliated with Orthostatic Intolerance

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Compounds related to Orthostatic Intolerance according to GeneCards Suite gene sharing:

(show top 50)    (show all 227)
idCompoundScoreTop Affiliating Genes
1rx8210022810.0ADRA2A, ADRA2C, ADRA2B
2medetomidine hydrochloride5910.0ADRA2B, ADRA2C, ADRA2A
3arc-2392810.0ADRA2C, ADRA2A, ADRA2B
4brl 444082810.0ADRA2C, ADRA2A, ADRA2B
5[3h]rx8210022810.0ADRA2B, ADRA2A, ADRA2C
6brl 44408 maleate5910.0ADRA2C, ADRA2A, ADRA2B
7jp 1302 dihydrochloride5910.0ADRA2B, ADRA2A, ADRA2C
8atipamezole hydrochloride5910.0ADRA2B, ADRA2A, ADRA2C
9dexmedetomidine hydrochloride5910.0ADRA2B, ADRA2A, ADRA2C
10[3h]mk-9122810.0ADRA2C, ADRA2A, ADRA2B
11[3h]rauwolscine289.9ADRA2A, ADRA2B, ADRA2C
12(plusmn)-adrenaline289.9ADRA2B, ADRB1, ADRA2C
13xylazine43 2810.9ADRA2C, ADRA2A, ADRA2B
14tizanidine43 1210.9ADRA2C, ADRA2A, ADRA2B
15wb 4101289.8ADRA2C, ADRA2A, ADRA2B
16guanfacine28 43 1211.8ADRA2B, ADRA2A, ADRA2C
17doxepin43 28 49 1212.7ADRA2A, SLC6A2, ADRA2C, ADRA2B
18pseudoephedrine43 24 1211.7ADRB2, ADRA2A, ADRB1, SLC6A2
19phenoxybenzamine43 1210.7ADRA2B, ADRA2A, ADRA2C, ADRB2
20rauwolscine289.6ADRA2C, ADRA2A, ADRA2B
21prazosin43 28 49 1212.6ADRA2B, ADRB1, ADRA2A, ADRA2C
22(-)-noradrenaline289.5ADRA2C, ADRA2B, ADRA2A
23fenoldopam43 1210.5ADRA2B, REN, ADRA2C, ADRA2A
24labetalol43 1210.5REN, ADRB1, ADRB2
25bucindolol43 4910.4REN, ADRB1, ADRA2C, ADRB2
26asenapine28 1210.4ADRA2A, ADRA2C, ADRA2B, ADRB1, ADRB2
27risperidone43 49 28 59 24 1214.3ADRA2B, ADRA2A, ADRA2C, ADRB2, ADRB1
28bromocriptine43 28 1211.2ADRA2A, ADRA2B, POMC, ADRA2C
29metoprolol43 49 28 24 1213.1REN, NOS3, ADRB2, ADRB1
30clozapine43 28 49 1212.1ADRA2B, ADRA2A, ADRA2C, ADRB2, POMC
31muraglitazar43 4910.1REN, ADRB1, EDN1
32atenolol43 49 28 24 1212.8ADRB1, REN, ADRB2, ADRA2A, EDN1
33n(g),n(g)-dimethylarginine438.6NOS2, EDN1, NOS3
34carvedilol43 49 28 1211.5REN, ADRB1, ADRB2, NOS3, EDN1
35catecholamine438.4ADRB1, POMC, ADRA2A, ADRA2C, SLC6A2, REN
36nebivolol43 129.3EDN1, ADRB1, ADRB2, NOS2, NOS3
37clonidine43 49 28 1211.3ADRA2B, NOS3, REN, ADRA2C, ADRA2A, ADRB1
38nitroglycerin43 129.1EDN1, REN, NOS2, NOS3
39dopamine43 28 24 1211.1SLC6A2, REN, ADRB2, ADRA2C, ADRA2A, ADRB1
40forskolin43 49 1210.0POMC, ADRB1, ADRA2C, ADRB2, REN, SLC6A2
41cgmp43 288.9NOS2, REN, SLC6A2, NOS3, EDN1
42isoproterenol43 128.9ADRB2, ADRA2A, REN, NOS2, ADRB1, EDN1
43glucose437.9POMC, ECE1, ADRB1, ADRA2B, ADRA2A, ADRB2
44epinephrine43 24 129.8REN, EDN1, POMC, ADRB1, ADRA2A, ADRB2
45glutamate437.7ADRA2B, NOS3, NOS2, ADRB1, SLC6A2, ADRA2A
46phenylephrine43 28 24 1210.6ADRA2B, EDN1, POMC, ADRB1, ADRA2A, NOS2
47norepinephrine43 24 129.5ADRA2A, ADRA2C, ADRB2, REN, SLC6A2, ADRA2B
48acetylcholine43 49 28 24 1211.5ADRB2, SLC6A2, NOS3, NOS2, ACHE, POMC
49indomethacin43 28 59 1210.4POMC, ECE1, REN, NOS2, EDN1, NOS3
50nitric oxide43 24 129.0ADRB1, ECE1, NOS3, NOS2, REN, NAT1

GO Terms for genes affiliated with Orthostatic Intolerance

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Cellular components related to Orthostatic Intolerance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:00057689.4ECE1, ADRA2C, ADRB2
2integral component of plasma membraneGO:00058878.4ADRA2C, ADRA2A, ADRA2B, ADRB2, SLC6A2, ADRB1
3plasma membraneGO:00058866.8ADRA2A, ECE1, ADRB1, ADRA2B, ADRA2C, ADRB2

Biological processes related to Orthostatic Intolerance according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of uterine smooth muscle contractionGO:007047310.3ADRA2C, ADRA2A
2fear responseGO:004259610.2ADRB1, ADRA2A
3heat generationGO:003164910.1ADRB1, ADRB2
4vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:000202510.1ADRB1, ADRB2
5negative regulation of smooth muscle contractionGO:004598610.1ADRB1, ADRB2
6diet induced thermogenesisGO:000202410.1ADRB2, ADRB1
7activation of MAPK activity by adrenergic receptor signaling pathwayGO:007188310.0ADRA2C, ADRA2A, ADRA2B
8epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:003562510.0ADRA2B, ADRA2A, ADRA2C
9negative regulation of epinephrine secretionGO:003281110.0ADRA2B, ADRA2A, ADRA2C
10negative regulation of norepinephrine secretionGO:001070010.0ADRA2C, ADRA2A, ADRA2B
11activation of protein kinase B activityGO:003214810.0ADRA2B, ADRA2A, ADRA2C
12negative regulation of multicellular organism growthGO:004001510.0ADRB2, ADRB1
13female pregnancyGO:00075659.9ADRA2B, ADRA2A, ADRA2C
14negative regulation of calcium ion transportGO:00519269.9ADRA2A, NOS3
15negative regulation of cAMP biosynthetic processGO:00308189.8EDN1, ADRA2A
16regulation of sodium ion transportGO:00020289.8ADRB2, NOS3
17peptide hormone processingGO:00164869.8ECE1, POMC
18activation of adenylate cyclase activityGO:00071909.8ADRB2, ADRB1
19regulation of sensory perception of painGO:00519309.7ADRA2C, EDN1
20brown fat cell differentiationGO:00508739.7ADRB1, ADRB2
21platelet activationGO:00301689.6ADRA2C, ADRA2A, ADRA2B
22regulation of vasoconstrictionGO:00192299.5EDN1, ECE1, ADRA2A
23response to coldGO:00094099.5ADRB2, ADRB1
24arginine catabolic processGO:00065279.4NOS3, NOS2
25positive regulation of guanylate cyclase activityGO:00312849.4NOS3, NOS2
26regulation of insulin secretionGO:00507969.4ADRA2A, ADRA2C, NOS2
27nitric oxide biosynthetic processGO:00068099.4NOS2, NOS3
28regulation of blood pressureGO:00082179.3NOS3, REN, POMC
29regulation of systemic arterial blood pressure by endothelinGO:00031009.3NOS3, ECE1, EDN1
30G-protein coupled receptor signaling pathwayGO:00071869.3ADRA2C, ADRA2A, ADRA2B, EDN1
31nitric oxide mediated signal transductionGO:00072639.3NOS2, NOS3
32positive regulation of vasodilationGO:00459099.2ADRA2A, NOS2, NOS3
33cell-cell signalingGO:00072679.2EDN1, POMC, ADRA2B, ADRA2C
34negative regulation of blood pressureGO:00457769.2NOS2, NOS3
35blood coagulationGO:00075968.7ADRA2B, ADRA2A, ADRA2C, NOS2, NOS3

Molecular functions related to Orthostatic Intolerance according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1alpha-2A adrenergic receptor bindingGO:00316949.9ADRA2C, ADRB1
2alpha2-adrenergic receptor activityGO:00049389.8ADRA2B, ADRA2A, ADRA2C
3norepinephrine bindingGO:00513809.7ADRB2, ADRA2A, ADRB1
4epinephrine bindingGO:00513799.5ADRA2C, ADRA2A, ADRA2B, ADRB1
5nitric-oxide synthase activityGO:00045179.3NOS3, NOS2
6arginine bindingGO:00346189.2NOS2, NOS3
7tetrahydrobiopterin bindingGO:00346179.2NOS2, NOS3
8FMN bindingGO:00101819.1NOS3, NOS2
9NADPH-hemoprotein reductase activityGO:00039589.0NOS2, NOS3
10protein homodimerization activityGO:00428038.1ECE1, ADRA2A, ADRA2C, ADRB2, ACHE, NOS2
11protein bindingGO:00055156.1EDN1, ADRB1, ADRA2B, ADRA2A, ADRA2C, ADRB2

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