Orthostatic Intolerance malady
Categories: Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases, Cardiovascular diseases
Aliases & Descriptions for Orthostatic Intolerance:
Orphanet epidemiological data:52
familial orthostatic tachycardia due to norepinephrine transporter deficiency:
Inheritance: Autosomal dominant
Inheritance: autosomal dominant inheritance
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases, Cardiovascular diseases
Rare neurological diseases
MedlinePlus:36 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute
MalaCards based summary: Orthostatic Intolerance, also known as mitral valve prolapse, is related to familial mitral valve prolapse and mitral valve prolapse, myxomatous 2, and has symptoms including chest pain, chest pain and mitral facies. An important gene associated with Orthostatic Intolerance is SLC6A2 (Solute Carrier Family 6 Member 2), and among its related pathways are NO-dependent CFTR activation (normal and CF) and Effects of nitric oxide. Affiliated tissues include heart, brain and lung, and related mouse phenotypes are renal/urinary system and vision/eye.
Disease Ontology:11 A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities.
UniProtKB/Swiss-Prot:68 Orthostatic intolerance: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
Wikipedia:69 Orthostatic intolerance (OI) is the development of symptoms when standing upright which are relieved... more...
Description from OMIM:50 604715
Drugs for Orthostatic Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 110)
Interventional clinical trials:(show top 50) (show all 187)
Search NIH Clinical Center for Orthostatic Intolerance
MalaCards organs/tissues related to Orthostatic Intolerance:34
Heart, Brain, Lung, Testes, Spinal cord, Endothelial, Breast
MGI Mouse Phenotypes related to Orthostatic Intolerance:39 (show all 13)
Articles related to Orthostatic Intolerance:(show top 50) (show all 269)
UniProtKB/Swiss-Prot genetic disease variations for Orthostatic Intolerance:68
Clinvar genetic disease variations for Orthostatic Intolerance:5
Search GEO for disease gene expression data for Orthostatic Intolerance.
Pathways related to Orthostatic Intolerance according to GeneCards Suite gene sharing:(show all 18)
Cellular components related to Orthostatic Intolerance according to GeneCards Suite gene sharing:
Biological processes related to Orthostatic Intolerance according to GeneCards Suite gene sharing:(show all 38)
Molecular functions related to Orthostatic Intolerance according to GeneCards Suite gene sharing:(show all 11)
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet