Aliases & Classifications for Osmotic Diarrhea

MalaCards integrated aliases for Osmotic Diarrhea:

Name: Osmotic Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050130
UMLS 69 C0267556

Summaries for Osmotic Diarrhea

Disease Ontology : 12 Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

MalaCards based summary : Osmotic Diarrhea is related to diarrhea and trehalase deficiency, and has symptoms including diarrhea An important gene associated with Osmotic Diarrhea is SLC5A1 (Solute Carrier Family 5 Member 1), and among its related pathways/superpathways are Carbohydrate digestion and absorption and Mineral absorption. The drugs Cathartics and Laxatives have been mentioned in the context of this disorder. Affiliated tissues include colon and small intestine.

Related Diseases for Osmotic Diarrhea

Diseases related to Osmotic Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 diarrhea 30.0 LCT MME SLC26A3 SLC5A1 SLC9A3
2 trehalase deficiency 11.0
3 lactose intolerance 10.3 LCT SLC5A1
4 hemophagocytic lymphohistiocytosis, familial, 5 10.3 SLC9A3 STXBP2
5 diarrhea 1, secretory chloride, congenital 10.2 SLC26A3 SLC9A3
6 secretory diarrhea 10.1 SLC26A3 SLC9A3
7 diarrhea 2, with microvillus atrophy 10.1 SLC26A3 SLC9A3 STXBP2
8 spermatocele 10.0 MME SLC26A3
9 perinephritis 10.0 HTR7 MGAM
10 coronary artery vasospasm 10.0 HTR7 MGAM
11 shigellosis 9.8
12 primary hypomagnesemia 9.8 MGAM SLC5A1

Graphical network of the top 20 diseases related to Osmotic Diarrhea:



Diseases related to Osmotic Diarrhea

Symptoms & Phenotypes for Osmotic Diarrhea

UMLS symptoms related to Osmotic Diarrhea:


diarrhea

Drugs & Therapeutics for Osmotic Diarrhea

Drugs for Osmotic Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cathartics
2 Laxatives
3 Cola Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
2 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971
3 Stability of the Microbiome in IBD and IBS Recruiting NCT03395548 Macrogol
4 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297

Search NIH Clinical Center for Osmotic Diarrhea

Genetic Tests for Osmotic Diarrhea

Anatomical Context for Osmotic Diarrhea

MalaCards organs/tissues related to Osmotic Diarrhea:

38
Colon, Small Intestine

Publications for Osmotic Diarrhea

Articles related to Osmotic Diarrhea:

(show all 12)
# Title Authors Year
1
Alterations in the colonic microbiota in response to osmotic diarrhea. ( 23409050 )
2013
2
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. ( 18797153 )
2008
3
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. ( 17171792 )
2006
4
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. ( 11677212 )
2001
5
Oral rehydration solutions: increased water and sodium absorption by addition of a viscosity-enhancing agent in a rat model of chronic osmotic diarrhea. ( 7876995 )
1994
6
Zinc absorption in experimental osmotic diarrhea: effect of long-chain fatty acids. ( 8400847 )
1993
7
Improved water and sodium absorption from oral rehydration solutions based on rice syrup in a rat model of osmotic diarrhea. ( 2007957 )
1991
8
Osmotic diarrhea induced by sugar-free theophylline solution in critically ill patients. ( 1907685 )
1991
9
Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. ( 2794043 )
1989
10
Oral hydration solutions in experimental osmotic diarrhea: enhancement by alanine and other amino acids and oligopeptides. ( 3389333 )
1988
11
The differentiation of osmotic diarrhea from shigellosis. ( 1263492 )
1976
12
Osmotic diarrhea due to high sodium chloride intake following subtotal resection to the small intestine. ( 5435237 )
1970

Variations for Osmotic Diarrhea

Expression for Osmotic Diarrhea

Search GEO for disease gene expression data for Osmotic Diarrhea.

Pathways for Osmotic Diarrhea

Pathways related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 LCT MGAM SLC5A1
2 10.63 SLC26A3 SLC5A1 SLC9A3 TRPV6
3 10.11 LCT MGAM

GO Terms for Osmotic Diarrhea

Cellular components related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.8 ATP8B1 BSCL2 CLDN2 HTR7 LCT MGAM
2 integral component of plasma membrane GO:0005887 9.76 ATP8B1 HTR7 LCT MMD MME SLC26A3
3 brush border membrane GO:0031526 9.5 ATP8B1 SLC26A3 SLC9A3
4 apical plasma membrane GO:0016324 9.1 ATP8B1 LCT MGAM SLC26A3 SLC9A3 STXBP2
5 membrane GO:0016020 10.21 ATP8B1 BSCL2 CLDN2 HTR7 LCT MGAM
6 plasma membrane GO:0005886 10.03 ATP8B1 CLDN2 HTR7 LCT MGAM MME

Biological processes related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of intracellular pH GO:0051453 8.96 SLC26A3 SLC9A3
2 polysaccharide digestion GO:0044245 8.62 LCT MGAM

Molecular functions related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.62 LCT MGAM

Sources for Osmotic Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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