Aliases & Classifications for Osmotic Diarrhea

MalaCards integrated aliases for Osmotic Diarrhea:

Name: Osmotic Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050130

Summaries for Osmotic Diarrhea

Disease Ontology : 12 Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

MalaCards based summary : Osmotic Diarrhea is related to trehalase deficiency and blind loop syndrome, and has symptoms including diarrhea An important gene associated with Osmotic Diarrhea is SLC5A1 (Solute Carrier Family 5 Member 1), and among its related pathways/superpathways are Carbohydrate digestion and absorption and Mineral absorption. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include colon and small intestine.

Related Diseases for Osmotic Diarrhea

Diseases related to Osmotic Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 trehalase deficiency 10.9
2 blind loop syndrome 10.5 LCT SLC5A1
3 spondyloenchondrodysplasia with immune dysregulation 10.4 SLC9A3 STXBP2
4 spinocerebellar ataxia 18 10.3 SLC26A3 SLC9A3
5 leprechaunism 10.3 SLC5A1 SLC9A3
6 diarrhea 10.3
7 motility-related diarrhea 10.2 SLC26A3 SLC9A3
8 trachea sarcoma 10.1 MME SLC26A3
9 antiphospholipid syndrome 10.1 HTR7 MGAM
10 prune belly syndome 9.8 MGAM SLC5A1
11 shigellosis 9.7
12 typhoid fever 9.0 LCT MGAM MME SLC26A3 SLC5A1 SLC9A3
13 inflammatory diarrhea 4.8 ATP8B1 BSCL2 CLDN2 GIN1 HTR7 LARS

Graphical network of the top 20 diseases related to Osmotic Diarrhea:



Diseases related to Osmotic Diarrhea

Symptoms & Phenotypes for Osmotic Diarrhea

UMLS symptoms related to Osmotic Diarrhea:


diarrhea

Drugs & Therapeutics for Osmotic Diarrhea

Drugs for Osmotic Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3 Adrenergic Agents Phase 4
4 Atomoxetine Hydrochloride Phase 4
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4
9 Neurotransmitter Uptake Inhibitors Phase 4
10
Inulin Approved, Nutraceutical 9005-80-5 24763
11
Levan 9013-95-0 22833608
12 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study in Attention Deficit Hyperactivity Disorder in Children and Adolescents Terminated NCT01127646 Phase 4 Atomoxetine;Osmotic-release oral system methylphenidate;Placebo
2 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
3 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971
4 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
5 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
6 Investigation of Dietary Absorptive Capacity of Fructans in Healthy Subjects - A Dose Response Study Active, not recruiting NCT00988403

Search NIH Clinical Center for Osmotic Diarrhea

Genetic Tests for Osmotic Diarrhea

Anatomical Context for Osmotic Diarrhea

MalaCards organs/tissues related to Osmotic Diarrhea:

39
Colon, Small Intestine

Publications for Osmotic Diarrhea

Articles related to Osmotic Diarrhea:

(show all 12)
id Title Authors Year
1
Alterations in the colonic microbiota in response to osmotic diarrhea. ( 23409050 )
2013
2
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. ( 18797153 )
2008
3
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. ( 17171792 )
2006
4
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. ( 11677212 )
2001
5
Oral rehydration solutions: increased water and sodium absorption by addition of a viscosity-enhancing agent in a rat model of chronic osmotic diarrhea. ( 7876995 )
1994
6
Zinc absorption in experimental osmotic diarrhea: effect of long-chain fatty acids. ( 8400847 )
1993
7
Osmotic diarrhea induced by sugar-free theophylline solution in critically ill patients. ( 1907685 )
1991
8
Improved water and sodium absorption from oral rehydration solutions based on rice syrup in a rat model of osmotic diarrhea. ( 2007957 )
1991
9
Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. ( 2794043 )
1989
10
Oral hydration solutions in experimental osmotic diarrhea: enhancement by alanine and other amino acids and oligopeptides. ( 3389333 )
1988
11
The differentiation of osmotic diarrhea from shigellosis. ( 1263492 )
1976
12
Osmotic diarrhea due to high sodium chloride intake following subtotal resection to the small intestine. ( 5435237 )
1970

Variations for Osmotic Diarrhea

Expression for Osmotic Diarrhea

Search GEO for disease gene expression data for Osmotic Diarrhea.

Pathways for Osmotic Diarrhea

Pathways related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.78 LCT MGAM SLC5A1
2 10.63 SLC26A3 SLC5A1 SLC9A3 TRPV6
3 10.11 LCT MGAM

GO Terms for Osmotic Diarrhea

Cellular components related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 ATP8B1 HTR7 LCT MMD MME SLC26A3
2 brush border membrane GO:0031526 9.26 ATP8B1 SLC26A3 SLC5A1 SLC9A3
3 apical plasma membrane GO:0016324 9.17 ATP8B1 LCT MGAM SLC26A3 SLC5A1 SLC9A3
4 membrane GO:0016020 10.21 ATP8B1 BSCL2 CLDN2 HTR7 LCT MGAM
5 plasma membrane GO:0005886 10.1 ATP8B1 CLDN2 HTR7 LCT MGAM MME
6 integral component of membrane GO:0016021 10 ATP8B1 BSCL2 CLDN2 HTR7 LCT MGAM

Biological processes related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of intracellular pH GO:0051453 8.96 SLC26A3 SLC9A3
2 polysaccharide digestion GO:0044245 8.62 LCT MGAM

Molecular functions related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.62 LCT MGAM

Sources for Osmotic Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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