MCID: OSM001
MIFTS: 28

Osmotic Diarrhea malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Osmotic Diarrhea

Aliases & Descriptions for Osmotic Diarrhea:

Name: Osmotic Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050130

Summaries for Osmotic Diarrhea

Disease Ontology : 12 Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

MalaCards based summary : Osmotic Diarrhea is related to trehalase deficiency and diarrhea, and has symptoms including diarrhea An important gene associated with Osmotic Diarrhea is SLC5A1 (Solute Carrier Family 5 Member 1), and among its related pathways/superpathways are Carbohydrate digestion and absorption and Mineral absorption. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include colon and small intestine.

Related Diseases for Osmotic Diarrhea

Diseases related to Osmotic Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 trehalase deficiency 10.9
2 diarrhea 10.3
3 tropical sprue 10.2 LCT SLC5A1
4 glomerulosclerosis, focal segmental, 1 10.2 SLC5A1 SLC9A3
5 adenoiditis 10.1 MME XK
6 mednik syndrome 10.0 SLC26A3 SLC9A3 XK
7 inflammatory diarrhea 10.0 SLC26A3 SLC9A3 XK
8 ectopic cushing syndrome 10.0 MGAM SLC5A1
9 adenocarcinoma 10.0 HTR7 MGAM
10 transsexualism 10.0 MGAM XK
11 trachea sarcoma 10.0 MME SLC26A3
12 cataract 29, coralliform 9.9 MGAM XK
13 typhoid fever 9.8 MGAM MME SLC26A3 SLC9A3
14 shigellosis 9.7
15 superficial mycosis 8.0 ATP8B1 BSCL2 GIN1 HTR7 LARS LCT

Graphical network of the top 20 diseases related to Osmotic Diarrhea:



Diseases related to Osmotic Diarrhea

Symptoms & Phenotypes for Osmotic Diarrhea

UMLS symptoms related to Osmotic Diarrhea:


diarrhea

Drugs & Therapeutics for Osmotic Diarrhea

Drugs for Osmotic Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3 Adrenergic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5 Neurotransmitter Uptake Inhibitors Phase 4
6 Dopamine Agents Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Atomoxetine Hydrochloride Phase 4
9 Central Nervous System Stimulants Phase 4
10 Pharmaceutical Solutions Phase 3
11
Nitric Oxide Approved Phase 2 10102-43-9 145068
12
Isosorbide Dinitrate Approved Phase 2 87-33-2 6883
13
Cilostazol Approved Phase 2 73963-72-1 2754
14
Misoprostol Approved Phase 2 59122-46-2 5282381
15
Inulin Approved, Nutraceutical Phase 2 9005-80-5 24763
16
Levan Phase 2 9013-95-0 22833608
17 diuretics Phase 2,Phase 1
18 Natriuretic Agents Phase 2,Phase 1
19 isosorbide-5-mononitrate Phase 2
20 Gastrointestinal Agents Phase 2
21 Neuroprotective Agents Phase 2
22 Nitric Oxide Donors Phase 2
23 Oxytocics Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Vasodilator Agents Phase 2
26 Antacids Phase 2
27 Anti-Asthmatic Agents Phase 2
28 Phosphodiesterase 3 Inhibitors Phase 2
29 Phosphodiesterase Inhibitors Phase 2
30 Platelet Aggregation Inhibitors Phase 2
31 Fibrinolytic Agents Phase 2
32 Protective Agents Phase 2
33 Isosorbide Phase 2
34 Respiratory System Agents Phase 2
35 Anti-Ulcer Agents Phase 2
36 Autonomic Agents Phase 2
37 Bronchodilator Agents Phase 2
38
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
39 Chelating Agents Phase 1
40 Parasympatholytics
41 Laxatives
42 Bile Acids and Salts
43 Cathartics
44 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study in Attention Deficit Hyperactivity Disorder in Children and Adolescents Terminated NCT01127646 Phase 4
2 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
3 Efficacy, Safety and Tolerability of Eziclen®/Izinova® Versus Klean-prep® on Bowel Cleansing in Adolescents Undergoing Colonoscopy Not yet recruiting NCT03008460 Phase 3
4 Investigation of Dietary Absorptive Capacity of Fructans in Healthy Subjects - A Dose Response Study Unknown status NCT00988403 Phase 2
5 Termination Of Anembryonic Pregnancy Recruiting NCT02573051 Phase 2
6 Lacunar Intervention Trial 1 (LACI-1) Recruiting NCT02481323 Phase 2
7 Trial of Mannitol Cream for Pain Relief After a Long Run Completed NCT01843088 Phase 1
8 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971
9 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
10 A Comparison of Three Different Treatment Options for Irritable Bowel Syndrome Not yet recruiting NCT02970591

Search NIH Clinical Center for Osmotic Diarrhea

Genetic Tests for Osmotic Diarrhea

Anatomical Context for Osmotic Diarrhea

MalaCards organs/tissues related to Osmotic Diarrhea:

39
Colon, Small Intestine

Publications for Osmotic Diarrhea

Articles related to Osmotic Diarrhea:

(show all 12)
id Title Authors Year
1
Alterations in the colonic microbiota in response to osmotic diarrhea. ( 23409050 )
2013
2
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. ( 18797153 )
2008
3
Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. ( 17171792 )
2006
4
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. ( 11677212 )
2001
5
Oral rehydration solutions: increased water and sodium absorption by addition of a viscosity-enhancing agent in a rat model of chronic osmotic diarrhea. ( 7876995 )
1994
6
Zinc absorption in experimental osmotic diarrhea: effect of long-chain fatty acids. ( 8400847 )
1993
7
Osmotic diarrhea induced by sugar-free theophylline solution in critically ill patients. ( 1907685 )
1991
8
Improved water and sodium absorption from oral rehydration solutions based on rice syrup in a rat model of osmotic diarrhea. ( 2007957 )
1991
9
Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. ( 2794043 )
1989
10
Oral hydration solutions in experimental osmotic diarrhea: enhancement by alanine and other amino acids and oligopeptides. ( 3389333 )
1988
11
The differentiation of osmotic diarrhea from shigellosis. ( 1263492 )
1976
12
Osmotic diarrhea due to high sodium chloride intake following subtotal resection to the small intestine. ( 5435237 )
1970

Variations for Osmotic Diarrhea

Expression for Osmotic Diarrhea

Search GEO for disease gene expression data for Osmotic Diarrhea.

Pathways for Osmotic Diarrhea

Pathways related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.78 LCT MGAM SLC5A1
2 10.63 SLC26A3 SLC5A1 SLC9A3 TRPV6
3 10.11 LCT MGAM

GO Terms for Osmotic Diarrhea

Cellular components related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 ATP8B1 HTR7 LCT MMD MME SLC26A3
2 brush border membrane GO:0031526 9.26 ATP8B1 SLC26A3 SLC5A1 SLC9A3
3 apical plasma membrane GO:0016324 9.17 ATP8B1 LCT MGAM SLC26A3 SLC5A1 SLC9A3
4 membrane GO:0016020 10.21 ATP8B1 BSCL2 HTR7 LCT MGAM MMD
5 plasma membrane GO:0005886 10.1 ATP8B1 HTR7 LCT MGAM MME SLC26A3
6 integral component of membrane GO:0016021 10 ATP8B1 BSCL2 HTR7 LCT MGAM MMD

Biological processes related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.7 ATP8B1 SLC26A3 SLC5A1 SLC9A3 STXBP2 TRPV6
2 regulation of intracellular pH GO:0051453 9.26 SLC26A3 SLC9A3
3 regulation of cell size GO:0008361 8.96 LARS XK
4 polysaccharide digestion GO:0044245 8.62 LCT MGAM

Molecular functions related to Osmotic Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.13 SLC26A3 SLC5A1 XK
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.62 LCT MGAM

Sources for Osmotic Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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