MCID: OSS001
MIFTS: 43

Ossifying Fibroma malady

Categories: Cancer diseases, Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

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Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 11 13 66
Peripheral Ossifying Fibroma 11 66
Fibroma, Ossifying 37
 
Fibroma Ossifying 48
Fibro-Osteoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:180
MeSH37 D018214
NCIt43 C8422

Summaries for Ossifying Fibroma

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Disease Ontology:11 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and MicroRNAs in cancer. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are neoplasm and respiratory system.

Related Diseases for Ossifying Fibroma

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Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile ossifying fibroma12.5
2osteofibrous dysplasia11.9
3gigantiform cementoma, familial11.3
4fibroma11.3
5hyperparathyroidism-jaw tumor syndrome10.7
6sinusitis10.5
7fibrous dysplasia10.5
8aneurysmal bone cysts10.4
9aneurysm10.4
10pyogenic granuloma10.2
11hyperparathyroidism10.2
12gingivitis10.2
13bone osteosarcoma10.2GNAS, MDM2
14polyarticular onset juvenile idiopathic arthritis10.1MDM2, RASAL1
15sost-related sclerosing bone dysplasia10.1CDC73, GNAS
16immunodeficiency, common variable, 510.1CDC73, GNAS
17periodontitis10.1
18small cell osteogenic sarcoma10.1GNAS, MDM2
19male reproductive organ benign neoplasm10.0CDC73, GNAS
20chondrosarcoma10.0
21mastoiditis10.0
22neurofibromatosis10.0
23monostotic fibrous dysplasia10.0
24alpha chain disease10.0CDC73, GNAS, RASAL1
25sensory organ benign neoplasm10.0CDC73, GNAS, RASAL1
26trench fever9.9NOTCH1, NOTCH3
27buschke-ollendorff syndrome9.9
28retinoblastoma9.9
29neurofibromatosis, type 19.9
30oculoectodermal syndrome9.9
31adamantinoma of long bones9.9
32osteoblastoma9.9
33fanconi syndrome9.9
34sphenoid sinusitis9.9
35primary hyperparathyroidism9.9
36orbital cellulitis9.9
37chronic apical periodontitis9.9
38tuberous sclerosis9.9
39giant cell tumor9.9
40cellulitis9.9
41bilateral retinoblastoma9.9
42epulis9.9
43juxtacortical chondrosarcoma9.9
44adenoma9.9
45psammomatous meningioma9.9
46parathyroid adenoma9.9
47hyperthyroidism9.9
48exophthalmos9.9
49periostitis9.9
50fibromatosis9.9

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

34
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

17
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

39 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8GNAS, MDM2, NOTCH1, NOTCH3
2MP:00053888.5CDC73, GNAS, JAG2, NOTCH1, NOTCH3
3MP:00053708.3CDC73, GNAS, JAG1, MDM2, NOTCH1
4MP:00053778.2GNAS, JAG1, JAG2, NOTCH1, NOTCH3
5MP:00053828.2GNAS, JAG1, JAG2, MDM2, NOTCH1
6MP:00053878.1CDC73, GNAS, JAG2, MDM2, NOTCH1, NOTCH3
7MP:00053818.0CDC73, JAG1, JAG2, MDM2, NOTCH1
8MP:00028737.8GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053847.7CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
10MP:00053697.6CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
11MP:00053807.5CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
12MP:00053857.4CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
13MP:00107717.3CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
14MP:00053677.3CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
15MP:00053907.2GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
16MP:00053977.1CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
17MP:00107687.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
18MP:00036317.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
19MP:00053796.9CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
20MP:00053786.7CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
21MP:00053766.5CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. (27311848)
2016
2
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). (27476108)
2016
3
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. (27513775)
2016
4
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
5
Percutaneous cryoablation for a symptomatic non-ossifying fibroma. A case report. (25533495)
2015
6
Is Computed Tomography an Adequate Imaging Modality for the Evaluation of Juvenile Ossifying Fibroma? A Comparison of 2 Imaging Modalities (Computed Tomography and Magnetic Resonance Imaging). (25911216)
2015
7
Giant central ossifying fibroma of the maxilla presenting with a pus discharging intra-oral sinus. (25738089)
2015
8
Retrospective Analysis of Ossifying Fibroma of Jaw Bones Over a Period of 10 Years with Literature Review. (26225029)
2014
9
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
10
Huge ossifying fibroma of the maxilla. (25018610)
2014
11
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
12
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
13
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
14
Peripheral ossifying fibroma. (24174733)
2013
15
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
16
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
17
Asymptomatic ossifying fibroma of the mandible: a case presentation. (22536589)
2012
18
Peripheral Ossifying fibroma: a clinical report. (23097830)
2012
19
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
20
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
21
Peripheral cemento-ossifying fibroma--a case report. (21356015)
2011
22
Juvenile central ossifying fibroma of the mandible: a case report. (20920702)
2010
23
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
24
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
25
Juvenile aggressive ossifying fibroma of the maxilla. (19841549)
2009
26
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
27
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
28
Endoscopic resection of large sinonasal ossifying fibroma. (15635583)
2005
29
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
30
Ossifying fibroma of the skull: interactive image-guided minimally invasive localization and resection. (15346031)
2004
31
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
32
Juvenile ossifying fibroma: CT and MR findings. (12522617)
2002
33
Cemento-ossifying fibroma and benign cementoblastoma. (10587273)
1999
34
The natural course of an ossifying fibroma. A case report. (10609748)
1999
35
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
36
Maxillary sinus ossifying fibroma. (9395021)
1997
37
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
38
Massive cemento-ossifying fibroma: case report. (9584797)
1996
39
Non-ossifying fibroma of the spine. (24057475)
1996
40
Central ossifying fibroma. (8060568)
1993
41
Ossifying fibroma of the jaws: a case report. (1765021)
1991
42
Ossifying fibroma in the sylvian fissure: case report. (1870672)
1991
43
Ossifying fibroma of the long bones. Radiological diagnosis, differential diagnosis and management implications. (2061274)
1991
44
Periosteal ossifying fibroma of the palate. (6596423)
1984
45
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
46
Giantiform ossifying fibroma of maxillary bone. (409799)
1977
47
Cemento-ossifying fibroma of the mandible: report of a case. (1055193)
1975
48
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
49
Ossifying fibroma of mandible with a case report. (4197396)
1973
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.3NOTCH1, NOTCH3
28.8MDM2, NOTCH1, NOTCH3
38.8MDM2, NOTCH1, NOTCH3
4
Show member pathways
8.6JAG1, JAG2, NOTCH1
58.6JAG1, JAG2, NOTCH1
6
Show member pathways
8.6JAG1, JAG2, NOTCH1
7
Show member pathways
8.5JAG1, NOTCH1, NOTCH3
8
Show member pathways
8.1JAG1, JAG2, MDM2, NOTCH1
9
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
108.1JAG1, JAG2, NOTCH1, NOTCH3
11
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
12
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
137.7CDC73, JAG1, JAG2, NOTCH1, NOTCH3
14
Show member pathways
7.5JAG1, JAG2, MDM2, NOTCH1, NOTCH3
15
Show member pathways
6.4CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

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Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junctionGO:00059129.5JAG1, NOTCH1
2plasma membraneGO:00058866.7GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:000991210.1JAG2, NOTCH1
2protein destabilizationGO:003164810.1CDC73, MDM2
3embryonic hindlimb morphogenesisGO:003511610.0GNAS, NOTCH1
4neuron fate commitmentGO:00486639.9NOTCH1, NOTCH3
5endocardial cushion morphogenesisGO:00032039.9MDM2, NOTCH1
6atrioventricular valve morphogenesisGO:00031819.9MDM2, NOTCH1
7distal tubule developmentGO:00720179.7JAG1, NOTCH1
8negative regulation of stem cell differentiationGO:20007379.7JAG1, NOTCH1
9pulmonary valve morphogenesisGO:00031849.6JAG1, NOTCH1
10response to muramyl dipeptideGO:00324959.6JAG1, NOTCH1
11positive regulation of osteoblast differentiationGO:00456699.6GNAS, JAG1
12blood vessel remodelingGO:00019749.5JAG1, MDM2
13neuronal stem cell population maintenanceGO:00971509.5JAG1, NOTCH1
14Notch signaling involved in heart developmentGO:00613149.4JAG1, NOTCH1
15forebrain developmentGO:00309009.4NOTCH1, NOTCH3
16Notch receptor processingGO:00072209.1JAG1, JAG2, NOTCH3
17positive regulation of Notch signaling pathwayGO:00457479.0JAG1, JAG2, NOTCH1
18cardiac septum morphogenesisGO:00604119.0JAG1, MDM2, NOTCH1
19negative regulation of cell differentiationGO:00455968.9JAG1, NOTCH1, NOTCH3
20negative regulation of neuron differentiationGO:00456658.9JAG1, NOTCH1, NOTCH3
21regulation of cell proliferationGO:00421278.9JAG1, JAG2, NOTCH1
22regulation of cell migrationGO:00303348.7JAG1, JAG2, NOTCH1
23Notch signaling pathwayGO:00072198.4JAG1, JAG2, NOTCH1, NOTCH3
24negative regulation of transcription from RNA polymerase II promoterGO:00001228.2CDC73, MDM2, NOTCH1, NOTCH3
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.2CDC73, JAG1, NOTCH1, NOTCH3

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.0MDM2, NOTCH1, NOTCH3
2Notch bindingGO:00051128.9JAG1, JAG2, NOTCH1
3calcium ion bindingGO:00055098.1JAG1, JAG2, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet