MCID: OSS001
MIFTS: 47

Ossifying Fibroma malady

Categories: Genetic diseases, Cancer diseases, Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

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Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 10 12 65
Peripheral Ossifying Fibroma 10 65
Fibroma, Ossifying 36
 
Fibroma Ossifying 47
Fibro-Osteoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:180
MeSH36 D018214
NCIt42 C8422
UMLS65 C0206640, C1290783

Summaries for Ossifying Fibroma

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Disease Ontology:10 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to relapsing polychondritis and juvenile ossifying fibroma. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and MicroRNAs in cancer. Affiliated tissues include the mouth, bone and breast, and related mouse phenotypes are respiratory system and liver/biliary system.

Related Diseases for Ossifying Fibroma

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Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

33
Bone, Breast, Lung, Endothelial, T cells, Liver, Kidney

FMA organs/tissues related to Ossifying Fibroma:

16
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6CDC73, GNAS, JAG2, NOTCH1, NOTCH3
2MP:00053708.3CDC73, GNAS, JAG1, MDM2, NOTCH1
3MP:00053818.1CDC73, JAG1, JAG2, MDM2, NOTCH1
4MP:00028738.0GNAS, JAG1, MDM2, NOTCH1, NOTCH3
5MP:00053827.9GNAS, JAG1, JAG2, MDM2, NOTCH1
6MP:00053777.7GNAS, JAG1, JAG2, NOTCH1, NOTCH3
7MP:00053807.7CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
8MP:00053677.6CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053847.6CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
10MP:00053877.5CDC73, GNAS, JAG2, MDM2, NOTCH1, NOTCH3
11MP:00053697.5CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
12MP:00053857.3CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
13MP:00053797.3CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
14MP:00107717.2CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
15MP:00053907.2GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
16MP:00036317.2CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
17MP:00053767.1CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
18MP:00107687.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
19MP:00053787.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
20MP:00053976.5CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. (25402324)
2014
2
Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer. (25154726)
2014
3
An Analysis of Polymorphisms Within the Wnt Signaling Pathway in Relation to Ovarian Cancer Risk in a Polish Population. (24078348)
2013
4
Implementation of certified endometriosis centers: 5-year experience in German-speaking Europe. (23391712)
2013
5
Role of leukotriene antagonists and antihistamines in the treatment of allergic rhinitis. (23389557)
2013
6
Dose-escalation study of carbon ion radiotherapy for locally advanced squamous cell carcinoma of the uterine cervix (9902). (24183732)
2013
7
I^-Thalassemia mutations and hemoglobinopathies in Adana, Turkey: results from a single center study. (22851993)
2012
8
Analysis of expression and function of the inhibitory receptor ILT2 in lymphocytes from patients with autoimmune thyroid disease. (21551166)
2011
9
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. (20929185)
2010
10
Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma. (19545247)
2009
11
A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. (17899387)
2008
12
MCM-2, Ki-67 and PCNA protein expressions in pT3G2 colorectal cancer indicated lymph node involvement. (18383884)
2008
13
Diverticulosis and diverticulitis. (19186323)
2008
14
BRCA1/2 mutation analysis in male breast cancer families from North West England. (17636422)
2008
15
Viability of the isolated soleus muscle during long-term incubation. (16900237)
2006
16
Persistent pesticides in human breast milk and cryptorchidism. (16835070)
2006
17
Pathological skin picking in individuals with body dysmorphic disorder. (17088164)
2006
18
A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent. (17108115)
2006
19
Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization. (16472770)
2006
20
Cerebellar liponeurocytoma. (15851097)
2005
21
Comparison of C-reactive protein levels before and after coronary stenting and restenosis among patients treated with sirolimus-eluting versus bare metal stents. (15878000)
2005
22
Pseudohypoparathyroidism with Albright's hereditary osteodystrophy (AHO) phenotype. (15633718)
2004
23
The Mad2 spindle checkpoint protein has two distinct natively folded states. (15024386)
2004
24
Connective tissue remodeling induced by carbon dioxide laser resurfacing of photodamaged human skin. (15545540)
2004
25
Prevalence of spontaneous oral dyskinesia in the elderly: a reappraisal. (15300653)
2004
26
Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo. (15111505)
2004
27
Herpes simplex virus type 1 tegument protein VP22 interacts with TAF- I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT. (12917472)
2003
28
In vitro characterization of a human calcitonin receptor gene polymorphism. (12517415)
2003
29
Combined effect of MPO, GSTM1 and GSTT1 polymorphisms on chromosome aberrations and lung cancer risk. (14626895)
2003
30
Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channels. (12887969)
2003
31
A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. (11162647)
2001
32
Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. (11104776)
2001
33
Prolonged response to cyclosporin-A in hypoplastic refractory anemia and correlation with in vitro studies. (10681719)
2000
34
Brief report: incidence of and risk factors for autistic disorder in neonatal intensive care unit survivors. (10382137)
1999
35
Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts. (10412048)
1999
36
Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. (10389722)
1999
37
Immunohistochemical analysis of 1,25-dihydroxyvitamin D3 receptor in cervical carcinoma. (9792274)
1998
38
Functional assessment for shoulder impingement syndrome after anterior acromioplasty. (9294915)
1997
39
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. (9379894)
1997
40
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. (8759641)
1996
41
Interleukin 2-dependent immunoregulatory function in hemodialysis patients with chronic hepatitis C. (8574431)
1995
42
A case of one eye with gelatinous drop-like corneal dystrophy and the other eye with band-shaped spheroidal corneal degeneration. (7746654)
1995
43
Increase of activity of angiotensin-converting enzyme in insulin-dependent diabetic patients with permanent microalbuminuria]. (1336356)
1992
44
Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. (2170010)
1990
45
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
46
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
47
Heterogeneity of acute undifferentiated leukemia at the immunoglobulin and T-cell receptor genes level. (3104260)
1987
48
Establishment of erythropoiesis following bone marrow transplantation in a patient with congenital hypoplastic anemia (Diamond-Blackfan syndrome). (786411)
1976
49
Leukocoria-pseudoglioma. (5763569)
1969
50
Cases of laryngitis, relieved by operation. (20895759)
1842

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.3NOTCH1, NOTCH3
28.8MDM2, NOTCH1, NOTCH3
38.8MDM2, NOTCH1, NOTCH3
4
Show member pathways
8.6JAG1, JAG2, NOTCH1
5
Show member pathways
8.6JAG1, JAG2, NOTCH1
68.6JAG1, JAG2, NOTCH1
7
Show member pathways
8.1JAG1, JAG2, MDM2, NOTCH1
88.1JAG1, JAG2, NOTCH1, NOTCH3
9
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
10
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
11
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
12
Show member pathways
7.5JAG1, JAG2, MDM2, NOTCH1, NOTCH3
13
Show member pathways
6.4CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

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Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Notch signaling pathwayGO:00457479.9JAG2, NOTCH1
2forebrain developmentGO:00309009.8NOTCH1, NOTCH3
3neuron fate commitmentGO:00486639.8NOTCH1, NOTCH3
4endocardial cushion morphogenesisGO:00032039.8MDM2, NOTCH1
5cell communicationGO:00071549.8JAG1, JAG2
6blood vessel remodelingGO:00019749.7JAG1, MDM2
7Notch signaling involved in heart developmentGO:00613149.6JAG1, NOTCH1
8response to muramyl dipeptideGO:00324959.6JAG1, NOTCH1
9pulmonary valve morphogenesisGO:00031849.6JAG1, NOTCH1
10keratinocyte differentiationGO:00302169.6JAG1, NOTCH1
11neuronal stem cell population maintenanceGO:00971509.6JAG1, NOTCH1
12positive regulation of osteoblast differentiationGO:00456699.5GNAS, JAG1
13regulation of cell migrationGO:00303349.4JAG1, NOTCH1
14Notch receptor processingGO:00072209.3JAG2, NOTCH1, NOTCH3
15cell differentiationGO:00301549.2JAG2, NOTCH1, NOTCH3
16cardiac septum morphogenesisGO:00604119.0JAG1, MDM2, NOTCH1
17Notch signaling pathwayGO:00072198.8JAG1, NOTCH1, NOTCH3
18regulation of cell proliferationGO:00421278.6JAG1, JAG2, NOTCH1
19negative regulation of neuron differentiationGO:00456658.6JAG1, NOTCH1, NOTCH3
20multicellular organism developmentGO:00072758.3JAG1, JAG2, NOTCH1
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.1CDC73, JAG1, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet