MCID: OSS001
MIFTS: 41

Ossifying Fibroma

Categories: Cancer diseases, Bone diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 12 14 69
Peripheral Ossifying Fibroma 12 69
Fibroma, Ossifying 42
Fibroma Ossifying 52
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 42 D018214
NCIt 47 C8422
UMLS 69 C0206640

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include bone, testes and bone marrow, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 12.4
2 osteofibrous dysplasia 11.8
3 hyperparathyroidism-jaw tumor syndrome 11.5
4 gigantiform cementoma, familial 11.2
5 fibroma 11.1
6 encephalocraniocutaneous lipomatosis 11.0
7 sinusitis 10.4
8 fibrous dysplasia 10.4
9 juvenile-onset small-fiber polyneuropathy 10.3 MDM2 RASAL1
10 small cell osteogenic sarcoma 10.2 GNAS MDM2
11 aneurysm 10.2
12 aneurysmal bone cysts 10.2
13 male reproductive organ benign neoplasm 10.2 CDC73 GNAS
14 conventional central osteosarcoma 10.1 GNAS MDM2
15 pyogenic granuloma 10.1
16 hyperparathyroidism 10.1
17 gingivitis 10.1
18 periodontitis 10.0
19 non-dystrophic myotonic disorders 10.0 JAG1 NOTCH1
20 monostotic fibrous dysplasia 9.9
21 osteoblastoma 9.9
22 mastoiditis 9.9
23 chondrosarcoma 9.9
24 worth's syndrome 9.9 CDC73 GNAS
25 opiate dependence 9.9 JAG1 NOTCH1
26 trophoblastic neoplasm 9.8 JAG1 NOTCH1
27 oculoectodermal syndrome 9.8
28 cellulitis 9.8
29 bilateral retinoblastoma 9.8
30 keratocystic odontogenic tumor 9.8
31 adamantinoma of long bones 9.8
32 epulis 9.8
33 juxtacortical chondrosarcoma 9.8
34 adenoma 9.8
35 psammomatous meningioma 9.8
36 parathyroid adenoma 9.8
37 hyperthyroidism 9.8
38 fanconi syndrome 9.8
39 sphenoid sinusitis 9.8
40 exophthalmos 9.8
41 orbital cellulitis 9.8
42 periostitis 9.8
43 chronic apical periodontitis 9.8
44 fibromatosis 9.8
45 buschke-ollendorff syndrome 9.8
46 tuberous sclerosis 9.8
47 florid cemento-osseous dysplasia 9.8
48 retinoblastoma 9.8
49 giant cell tumor 9.8
50 lipoblastoma 9.8

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
2 cellular MP:0005384 10.13 GNAS JAG1 MDM2 NOTCH1 NOTCH3 CDC73
3 hematopoietic system MP:0005397 10.11 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
4 homeostasis/metabolism MP:0005376 10.1 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
5 endocrine/exocrine gland MP:0005379 10.09 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
6 cardiovascular system MP:0005385 10.07 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
7 integument MP:0010771 10.06 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
8 embryo MP:0005380 10.03 CDC73 JAG1 JAG2 MDM2 NOTCH1 NOTCH3
9 immune system MP:0005387 10.02 CDC73 ERCC6 GNAS JAG2 MDM2 NOTCH1
10 mortality/aging MP:0010768 10.01 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
11 hearing/vestibular/ear MP:0005377 10 GNAS JAG1 JAG2 NOTCH1 NOTCH3 ERCC6
12 craniofacial MP:0005382 9.97 MDM2 NOTCH1 GNAS JAG1 JAG2
13 digestive/alimentary MP:0005381 9.97 CDC73 JAG1 JAG2 MDM2 NOTCH1
14 liver/biliary system MP:0005370 9.91 ERCC6 GNAS JAG1 MDM2 NOTCH1 CDC73
15 muscle MP:0005369 9.91 CDC73 ERCC6 GNAS JAG1 MDM2 NOTCH1
16 nervous system MP:0003631 9.86 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
17 neoplasm MP:0002006 9.72 GNAS MDM2 NOTCH1 NOTCH3 ERCC6
18 renal/urinary system MP:0005367 9.63 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
19 respiratory system MP:0005388 9.35 CDC73 GNAS JAG2 NOTCH1 NOTCH3
20 skeleton MP:0005390 9.17 ERCC6 GNAS JAG1 JAG2 MDM2 NOTCH1

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

MalaCards organs/tissues related to Ossifying Fibroma:

39
Bone, Testes, Bone Marrow

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 611)
id Title Authors Year
1
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. ( 28588818 )
2017
2
Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study. ( 28195085 )
2017
3
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity. ( 28932332 )
2017
4
Ossifying fibroma: an uncommon differential diagnosis for T2-hypointense sinonasal masses. ( 28491178 )
2017
5
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. ( 28566876 )
2017
6
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. ( 28642188 )
2017
7
The role of Osterix protein in the pathogenesis of peripheral ossifying fibroma. ( 28678972 )
2017
8
Juvenile psammomatoid ossifying fibroma in paranasal sinus and skull base. ( 28125310 )
2017
9
A large psammomatoid ossifying fibroma with proptosis: A case report. ( 28357086 )
2017
10
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. ( 28292370 )
2017
11
940 nm Diode Laser assisted excision of Peripheral Ossifying Fibroma in a neonate. ( 28740329 )
2017
12
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
13
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. ( 27922957 )
2017
14
Ossifying fibroma of the maxilla and sinonasal tract: Case series. ( 28381325 )
2017
15
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report. ( 28402358 )
2017
16
Conservative Management of Central Cemento-Ossifying Fibroma. ( 27831973 )
2017
17
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. ( 28467645 )
2017
18
Osteofibrous Dysplasia Versus Ossifying Fibroma: Semantic Confusion. ( 28238823 )
2017
19
Pediatric cemento-ossifying fibroma of the orbital roof: Rare pathology at a rare location. ( 28681781 )
2017
20
Cemento-ossifying fibroma of the mandible. A clinicopathological report. ( 28439606 )
2017
21
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. ( 26740351 )
2016
22
Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery? ( 27192645 )
2016
23
Case of the Month: Peripheral Ossifying Fibroma. ( 27476233 )
2016
24
Orbital ossifying fibroma: A case report. ( 26928888 )
2016
25
Cemento-ossifying fibroma of the jaw. ( 27174452 )
2016
26
Nonvascularized Free Transport Distraction Osteogenesis to Reconstruct the Mandibular Defect of a Patient With an Ossifying Fibroma: AA Case Report. ( 27292526 )
2016
27
Erratum: Cemento-ossifying fibroma of the jaw. ( 27261511 )
2016
28
Juvenile Trabecular Ossifying Fibroma of the Maxilla: a Case Report. ( 28210024 )
2016
29
Oral Pathology. Common Oral Gingival Lesions. Diagnosis: Peripheral ossifying fibroma. ( 27263144 )
2016
30
Peripheral ossifying fibroma: A rare case affecting maxillary region. ( 27795650 )
2016
31
Cemento-ossifying fibroma of mandible mimicking complex composite odontome. ( 27797795 )
2016
32
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. ( 27044378 )
2016
33
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. ( 26962494 )
2016
34
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". ( 27888362 )
2016
35
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. ( 27513775 )
2016
36
Coverage Root after Removing Peripheral Ossifying Fibroma: 5-Year Follow-Up Case Report. ( 27891263 )
2016
37
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. ( 27192894 )
2016
38
Endonasal endoscopic resection of ossifying fibroma involving the ethmoid sinus, orbit and anterior skull base: case report and literature review. ( 27196080 )
2016
39
Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma. ( 28101383 )
2016
40
Cranial juvenile psammomatoid ossifying fibroma: case report. ( 26588460 )
2016
41
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). ( 27476108 )
2016
42
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. ( 27311848 )
2016
43
Unusually large-sized peripheral ossifying fibroma. ( 28299276 )
2016
44
Juvenile psammomatoid ossifying fibroma of the posterior fossa: a case report and review. ( 27468389 )
2016
45
Commentary on: "An update on peripheral ossifying fibroma: case report and literature review". ( 27891559 )
2016
46
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. ( 27658992 )
2016
47
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. ( 27134454 )
2016
48
Juvenile Psammomatoid Ossifying Fibroma: Findings on Bone Scan. ( 27405032 )
2016
49
Recurrent peripheral cemento-ossifying fibroma. ( 26229278 )
2015
50
Giant cemento-ossifying fibroma of the maxilla. ( 26108249 )
2015

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
2
Show member pathways
13.41 JAG1 JAG2 MDM2 NOTCH1 NOTCH3 RASAL1
3
Show member pathways
12.59 JAG1 JAG2 NOTCH1 NOTCH3
4
Show member pathways
12.27 JAG1 JAG2 NOTCH1 NOTCH3
5 12.25 GNAS JAG1 MDM2 NOTCH1 NOTCH3
6
Show member pathways
12.24 JAG1 JAG2 NOTCH1 NOTCH3
7 12.22 MDM2 NOTCH1 NOTCH3
8
Show member pathways
12.21 JAG1 JAG2 MDM2 NOTCH1 NOTCH3
9
Show member pathways
11.94 JAG1 JAG2 NOTCH1
10
Show member pathways
11.82 JAG1 JAG2 NOTCH1
11 11.72 MDM2 NOTCH1 NOTCH3
12 11.61 CDC73 JAG1 JAG2 NOTCH1 NOTCH3
13 11.48 JAG1 NOTCH1 NOTCH3
14 11.1 JAG1 JAG2 NOTCH1
15 10.74 JAG1 NOTCH1
16 10.59 JAG1 JAG2 NOTCH1
17 10.36 JAG1 JAG2 NOTCH1 NOTCH3

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 GNAS JAG1 NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.93 JAG2 NOTCH1 NOTCH3 RASAL1
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.91 CDC73 MDM2 NOTCH1 NOTCH3
3 regulation of cell proliferation GO:0042127 9.77 JAG1 JAG2 NOTCH1
4 regulation of cell migration GO:0030334 9.65 JAG1 JAG2 NOTCH1
5 negative regulation of cell differentiation GO:0045596 9.63 JAG1 NOTCH1 NOTCH3
6 positive regulation of osteoblast differentiation GO:0045669 9.62 GNAS JAG1
7 cell communication GO:0007154 9.62 JAG1 JAG2
8 protein destabilization GO:0031648 9.61 CDC73 MDM2
9 negative regulation of neuron differentiation GO:0045665 9.61 JAG1 NOTCH1 NOTCH3
10 blood vessel remodeling GO:0001974 9.59 JAG1 MDM2
11 neuron fate commitment GO:0048663 9.58 NOTCH1 NOTCH3
12 embryonic hindlimb morphogenesis GO:0035116 9.58 GNAS NOTCH1
13 neuronal stem cell population maintenance GO:0097150 9.57 JAG1 NOTCH1
14 endocardial cushion morphogenesis GO:0003203 9.56 MDM2 NOTCH1
15 negative regulation of stem cell differentiation GO:2000737 9.55 JAG1 NOTCH1
16 response to muramyl dipeptide GO:0032495 9.54 JAG1 NOTCH1
17 atrioventricular valve morphogenesis GO:0003181 9.52 MDM2 NOTCH1
18 pulmonary valve morphogenesis GO:0003184 9.51 JAG1 NOTCH1
19 Notch signaling involved in heart development GO:0061314 9.49 JAG1 NOTCH1
20 Notch signaling pathway GO:0007219 9.46 JAG1 JAG2 NOTCH1 NOTCH3
21 positive regulation of Notch signaling pathway GO:0045747 9.43 JAG1 JAG2 NOTCH1
22 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
23 auditory receptor cell fate commitment GO:0009912 9.32 JAG2 NOTCH1
24 Notch receptor processing GO:0007220 9.13 JAG1 JAG2 NOTCH3
25 regulation of developmental process GO:0050793 9.1 NOTCH1
26 cardiac septum morphogenesis GO:0060411 8.8 JAG1 MDM2 NOTCH1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 JAG1 JAG2 NOTCH1 NOTCH3
2 Notch binding GO:0005112 8.8 JAG1 JAG2 NOTCH1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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