MCID: OSS001
MIFTS: 50

Ossifying Fibroma malady

Bone diseases category

Summaries for Ossifying Fibroma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards: Ossifying Fibroma, also known as fibroma ossifying, is related to fibrous dysplasia and osteosarcoma. An important gene associated with Ossifying Fibroma is CDC73 (cell division cycle 73), and among its related pathways are Post-transcriptional Silencing By Small RNAs and Pre-NOTCH Processing in Golgi. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Wikipedia:63 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

Aliases & Classifications for Ossifying Fibroma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

ossifying fibroma 8 10 60
fibroma ossifying 44
fibro-osteoma 8


External Ids:

Disease Ontology8 DOID:180
MeSH34 D018214
NCIt39 C8422

Related Diseases for Ossifying Fibroma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.0GNAS, RUNX2, BGLAP
2osteosarcoma30.6NOTCH1, RUNX2, BGLAP
3osteofibrous dysplasia30.5GNAS, BGLAP
4hyperparathyroidism30.5CDC73, BGLAP
5chondrosarcoma30.4MUC1, RUNX2
6psammomatous meningioma30.1ERCC6
7parathyroid adenoma30.1CDC73, GNAS
8adenoma30.1GNAS, MUC1, CDC73
9bone fracture10.4
10gingivitis10.4
11meningioma10.4
12neurofibromatosis10.3
13periodontitis10.3
14osteoblastoma10.1
15bilateral retinoblastoma10.1
16chronic apical periodontitis10.1
17orbital cellulitis10.1
18primary hyperparathyroidism10.1
19cellulitis10.1
20exophthalmos10.1
21fanconi syndrome10.1
22adenomatoid tumor10.1
23juxtacortical chondrosarcoma10.1
24orbital cyst10.1
25epulis10.1
26giant cell tumor10.1
27hyperthyroidism10.1
28long bone adamantinoma10.1
29periostitis10.1
30retinoblastoma10.1
31skull base meningioma10.1
32sphenoid sinusitis10.1
33clear cell ependymoma10.0MUC1
34thyroid adenoma10.0GNAS
35sarcoma10.0MUC1
36craniosynostosis10.0RUNX2
37hypertension10.0NOTCH1
38choroid plexus papilloma10.0GFAP
39hyperphosphatemia10.0GNAS, RUNX2
40wermer syndrome10.0CDC73
41lung cancer10.0ERCC6, MUC1
42anaplastic ependymoma10.0MUC1, GFAP
43thyroid cancer10.0BGLAP, GNAS
44pseudohypoparathyroidism type 1b10.0BGLAP, GNAS
45ependymoma10.0GFAP, MUC1
46osteitis fibrosa10.0GNAS, BGLAP
47adenocarcinoma10.0NOTCH1, MUC1
48ovarian cancer10.0MUC1, NOTCH1
49progressive osseous heteroplasia10.0BGLAP, RUNX2, GNAS
50cleidocranial dysplasia10.0RUNX2, BGLAP

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Clinical Features for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ossifying Fibroma

Drug clinical trials:

Search ClinicalTrials for Ossifying Fibroma

Search NIH Clinical Center for Ossifying Fibroma

Search CenterWatch for Ossifying Fibroma

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Ossifying Fibroma:

32
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

14
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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36MGI
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Publications for Ossifying Fibroma

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50PubMed
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Articles related to Ossifying Fibroma:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Peripheral ossifying fibroma. (23696140)
2013
2
Juvenile ossifying fibroma of the maxilla: a rare aggressive case in a young patient. (23771389)
2013
3
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
4
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
5
Psammomatoid juvenile ossifying fibroma: an analysis of 2 cases affecting the mandible with review of the literature. (22668716)
2012
6
Concomitant occurrence of cemento-ossifying fibroma and adenomatoid odontogenic tumor with bilateral impacted permanent canines in the mandible. (23059596)
2012
7
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
8
Peripheral cemento-ossifying fibroma--a case report. (21356015)
2011
9
Mineralized components and their interpretation in the histogenesis of peripheral ossifying fibroma. (21525678)
2011
10
Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings. (20151312)
2011
11
Juvenile aggressive cemento-ossifying fibroma of the sinonasal tract: case report. (22109932)
2011
12
Peripheral ossifying fibroma. (21731281)
2011
13
Erratum to: Cemento-ossifying fibroma of the temporal bone. Acta Neurochir (2010) 152:1437-9. (21509564)
2011
14
Ossifying fibroma of maxilla in a male child: Report of a case and review of the literature. (22442615)
2011
15
Juvenile psammomatoid ossifying fibroma: a rare cause of unilateral proptosis. (22689605)
2011
16
Peripheral ossifying fibroma in the maxillary arch. (21985885)
2011
17
Juvenile ossifying fibroma of the maxilla. (21596643)
2011
18
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
19
Cranial ossifying fibroma causing visual disorder. (20485044)
2010
20
Peripheral ossifying fibroma: A clinical report. (22215935)
2010
21
Ossifying fibroma of the maxillary sinus at the Kara (Togo) Teaching Hospital. (21051307)
2010
22
Management of juvenile ossifying fibroma in the maxilla and mandible. (23139579)
2010
23
Psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of frontal sinus. (19484249)
2009
24
Large cemento-ossifying fibroma of the maxilla causing proptosis: a case report. (17706436)
2007
25
Aggressive cemento-ossifying fibroma. (18076835)
2007
26
Cemento-ossifying fibroma occurring in an elderly patient. A case report and a review of literature. (21503260)
2007
27
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
28
What is your diagnosis? Chronic juvenile ossifying fibroma. (17144815)
2006
29
Endoscopic resection of large sinonasal ossifying fibroma. (15635583)
2005
30
Ossifying fibroma of the middle turbinate: a case report. (15334407)
2004
31
Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities. (11925539)
2002
32
Autogenous bone marrow graft to non-ossifying fibroma with a pathologic fracture. (10968540)
2000
33
Ossifying fibroma in a llama. (11021440)
2000
34
Peripheral ossifying fibroma associated with a neonatal tooth: case report. (9866149)
1998
35
Ossifying fibroma of nasal cavity. (9510646)
1997
36
Juvenile active ossifying fibroma. Report of four cases. (9010430)
1997
37
Peripheral ossifying fibroma--literature update and clinical case. (9495932)
1997
38
Ossifying fibroma of the occipital bone. (7788973)
1995
39
Ossifying fibroma of the long bones. Radiological diagnosis, differential diagnosis and management implications. (2061274)
1991
40
Giant ossifying fibroma of the paranasal sinuses. (3366091)
1988
41
Cystic cemento-ossifying fibroma of the ethmoidal cells (a case report). (3668378)
1987
42
Non-ossifying fibroma of the metacarpal bone (a case report). (3273582)
1987
43
Clinical, computed tomographic, and histopathologic characteristics of juvenile ossifying fibroma with orbital involvement. (6638132)
1983
44
A case of ossifying fibroma of the parietal bone. (6176899)
1982
45
Non-ossifying fibroma. (502599)
1979
46
Cemento-ossifying fibroma of the mandible: report of a case. (1055193)
1975
47
Non-ossifying fibroma. Report of an intact lesion. (4827052)
1974
48
Non-ossifying fibroma of bone. A histochemical and ultrastructural characterization. (4274041)
1974
49
What is your diagnosis? Ossifying fibroma. (4624883)
1972
50
An ossifying fibroma of the middle ear. (5583746)
1967

Genetic Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ossifying Fibroma

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Pathways for genes affiliated with Ossifying Fibroma

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8NOTCH1, NOTCH3
2
Hide members
9.8NOTCH1, NOTCH3
39.8NOTCH1, NOTCH3
49.5NOTCH1, NOTCH3, GFAP
5
Hide members
9.5JAG2, JAG1, NOTCH1
69.4NOTCH1, NOTCH3, JAG1
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.2GNAS, RUNX2, BGLAP
8
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
9
Hide members
9.1JAG2, JAG1, NOTCH3, NOTCH1
10
Hide members
9.1JAG2, JAG1, NOTCH3, NOTCH1
119.1JAG2, JAG1, NOTCH3, NOTCH1
12
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
13
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
149.0BGLAP, RUNX2, NOTCH1
158.9JAG2, JAG1, CDC73, NOTCH3, NOTCH1
168.9NOTCH1, NOTCH3, JAG1, JAG2, RUNX2
17
Hide members
8.0GNAS, PPP1CC, JAG2, JAG1, GFAP, NOTCH3

Compounds for genes affiliated with Ossifying Fibroma

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1eosin4410.2GFAP, MUC1
2s 1004410.2MUC1, GFAP
3reticulin449.9GFAP, MUC1
4alizarin449.6RUNX2, BGLAP
5thymidine44 2410.5GFAP, MUC1, GNAS, RUNX2
6glycogen44 2410.1PPP1CC, MUC1, GFAP, NOTCH1
7lipid448.8RUNX2, GNAS, APOF, MUC1, GFAP, NOTCH1
8nitric oxide44 11 2410.7RUNX2, GNAS, JAG1, MUC1, NOTCH1
9dexamethasone44 49 28 1111.7BGLAP, RUNX2, MUC1, GFAP, NOTCH1
10vegf448.5BGLAP, RUNX2, MUC1, GFAP, NOTCH1
11calcium44 49 11 2410.5BGLAP, RUNX2, GNAS, PPP1CC, MUC1, GFAP

GO Terms for genes affiliated with Ossifying Fibroma

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16Gene Ontology
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Cellular components related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3NOTCH1, NOTCH3, MUC1, JAG1, APOF, GNAS

Biological processes related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:00991210.0NOTCH1, JAG2
2distal tubule developmentGO:07201710.0NOTCH1, JAG1
3negative regulation of stem cell differentiationGO:200073710.0NOTCH1, JAG1
4endochondral ossificationGO:00195810.0GNAS, RUNX2
5cardiac septum morphogenesisGO:0604119.9NOTCH1, JAG1
6pulmonary valve morphogenesisGO:0031849.9NOTCH1, JAG1
7Notch signaling involved in heart developmentGO:0613149.8NOTCH1, JAG1
8response to muramyl dipeptideGO:0324959.8JAG1, NOTCH1
9neuronal stem cell maintenanceGO:0971509.7NOTCH1, JAG1
10odontogenesis of dentin-containing toothGO:0424759.6ODAM, RUNX2, JAG2
11Notch receptor processingGO:0072209.4NOTCH1, NOTCH3, JAG1, JAG2
12Notch signaling pathwayGO:0072199.4JAG2, JAG1, NOTCH3, NOTCH1
13osteoblast developmentGO:0020769.1RUNX2, BGLAP

Molecular functions related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.9JAG1, JAG2
2calcium ion bindingGO:0055098.0NOTCH1, NOTCH3, JAG1, JAG2, BGLAP

Products for genes affiliated with Ossifying Fibroma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Ossifying Fibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet