MCID: OSS001
MIFTS: 55

Ossifying Fibroma malady

Cancer diseases, Bone diseases, Oral diseases categories

Summaries for Ossifying Fibroma

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Disease Ontology:9 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as fibroma ossifying, is related to fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is JAG2 (jagged 2), and among its related pathways are Notch signaling pathway and Dorso-ventral axis formation. The compounds alizarin and titanium have been mentioned in the context of this disorder. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Wikipedia:64 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

Aliases & Classifications for Ossifying Fibroma

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Ossifying Fibroma, Aliases & Descriptions:

Name: Ossifying Fibroma 9 11 61
Fibroma Ossifying 44
 
Fibro-Osteoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Oral diseases


External Ids:

Disease Ontology9 DOID:180
NCIt39 C8422
MeSH34 D018214

Related Diseases for Ossifying Fibroma

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Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma33.1CDC73
2osteofibrous dysplasia31.4GNAS, BGLAP
3fibrous dysplasia31.3GNAS, BGLAP, RUNX2
4hyperparathyroidism31.0CDC73, BGLAP
5psammomatous meningioma30.8ERCC6
6parathyroid adenoma30.8GNAS, CDC73
7primary hyperparathyroidism30.7BGLAP, CDC73
8meningioma30.7GFAP, MUC1
9giant cell tumor30.6BGLAP, MUC1
10osteosarcoma30.5RUNX2, BGLAP, NOTCH1
11sinusitis10.8
12aneurysmal bone cysts10.6
13aneurysm10.6
14pyogenic granuloma10.5
15chondroblastic osteosarcoma10.5BGLAP
16saethre-chotzen syndrome10.5BGLAP
17aortic valve disease10.4NOTCH1
18gingivitis10.4
19multiple endocrine neoplasia10.3GNAS, CDC73
20neurofibromatosis10.3
21chondrosarcoma10.3
22periodontitis10.3
23monostotic fibrous dysplasia10.3
24wermer syndrome10.3GNAS, CDC73
25pseudohypoparathyroidism type 1b10.3BGLAP, GNAS
26alagille syndrome10.3NOTCH1, JAG1
27osteitis fibrosa10.3BGLAP, GNAS
28pseudohypoparathyroidism10.3GNAS, BGLAP
29choroid plexus papilloma10.3GFAP
30osteomalacia10.3BGLAP, GNAS
31hyperphosphatemia10.2RUNX2, GNAS
32goiter10.2BGLAP, GNAS
33cleidocranial dysplasia10.2RUNX2, BGLAP
34abrikosov's tumor10.2GNAS, MUC1
35skeletal dysplasia multi-gene panels10.2GNAS, RUNX2
36brachydactyly10.2GNAS, RUNX2
37cadasil10.2JAG1, NOTCH3, NOTCH1
38osteopetrosis10.2RUNX2, BGLAP
39bone cancer10.2RUNX2, BGLAP
40fanconi syndrome10.2
41juxtacortical chondrosarcoma10.2
42exophthalmos10.2
43bilateral retinoblastoma10.2
44osteoblastoma10.2
45chronic apical periodontitis10.2
46orbital cellulitis10.2
47adenoma10.2
48cellulitis10.2
49epulis10.2
50hyperthyroidism10.2

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Drug clinical trials:

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Search NIH Clinical Center for Ossifying Fibroma

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

32
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

15
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

36 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2GNAS, JAG1, JAG2, NOTCH3, NOTCH1
2MP:00053679.0CDC73, NOTCH1, NOTCH3, JAG1, GNAS
3MP:00053829.0RUNX2, GNAS, JAG1, JAG2, NOTCH1
4MP:00053808.9JAG1, JAG2, NOTCH3, NOTCH1, CDC73
5MP:00053888.8RUNX2, GNAS, JAG2, NOTCH3, NOTCH1, CDC73
6MP:00053718.7RUNX2, GNAS, JAG2, ERCC6
7MP:00053898.7CDC73, NOTCH3, HMMR, JAG2, RUNX2
8MP:00030128.7RUNX2, GNAS, MUC1, JAG1, JAG2
9MP:00053908.4RUNX2, GNAS, JAG1, JAG2, ERCC6, NOTCH3
10MP:00020068.4MUC1, ERCC6, HMMR, NOTCH3, NOTCH1
11MP:00053868.3GFAP, GNAS, JAG1, ERCC6, NOTCH3, CDC73
12MP:00053858.3RUNX2, GFAP, GNAS, JAG1, NOTCH3, NOTCH1
13MP:00053798.2RUNX2, GNAS, MUC1, JAG1, NOTCH3, NOTCH1
14MP:00028738.2GFAP, GNAS, MUC1, JAG1, NOTCH3, NOTCH1
15MP:00053978.1RUNX2, GNAS, JAG1, JAG2, ERCC6, NOTCH3
16MP:00053708.1RUNX2, GNAS, MUC1, JAG1, ERCC6, NOTCH1
17MP:00053818.1RUNX2, GFAP, MUC1, JAG1, JAG2, NOTCH1
18MP:00053918.0RUNX2, GFAP, MUC1, JAG1, ERCC6, NOTCH1
19MP:00053697.9RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
20MP:00053877.9RUNX2, GFAP, GNAS, JAG2, ERCC6, NOTCH3
21MP:00053847.8RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
22MP:00053787.8RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
23MP:00036317.6RUNX2, GFAP, GNAS, JAG1, JAG2, ERCC6
24MP:00107687.6RUNX2, GFAP, GNAS, JAG1, JAG2, ERCC6
25MP:00107717.6CDC73, RUNX2, GNAS, MUC1, JAG1, JAG2
26MP:00053767.0RUNX2, GFAP, GNAS, MUC1, JAG1, JAG2

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
An unusual presentation of peripheral ossifying fibroma in an elderly man. (24925549)
2014
2
Juvenile ossifying fibroma of the middle turbinate. (25075725)
2014
3
Ossifying fibroma in the sinonasal tract: a rare case report. (25302205)
2014
4
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
5
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
6
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
7
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
8
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
9
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
10
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
11
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
12
Placement of implants in an ossifying fibroma defect obliterated with demineralized, freeze-dried bone allograft and Plasma-rich growth factor. (23633812)
2012
13
Asymptomatic ossifying fibroma of the mandible: a case presentation. (22536589)
2012
14
Trabecular and psammomatoid juvenile ossifying fibroma of the skull base mimicking psammomatoid meningioma. (20953744)
2011
15
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
16
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
17
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
18
A case report of cemento-ossifying fibroma. (22190782)
2010
19
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
20
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
21
Giant ossifying fibroma complicated by mucocele of sphenoid sinus--case report. (19105117)
2008
22
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
23
Case of the month: peripheral ossifying fibroma. (18546612)
2008
24
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
25
Ossifying fibroma of long bones in adults: a case report. (17260623)
2006
26
Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). (16407489)
2006
27
Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. (16632273)
2006
28
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
29
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
30
Ossifying fibroma of the jaw. (15372914)
2004
31
Psammomatoid ossifying fibroma of the ethmoid. (12784573)
2003
32
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
33
Aggressive psammomatoid ossifying fibroma of the inferior turbinate and lateral nasal wall. (12642959)
2003
34
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
35
Peripheral ossifying fibroma of the maxillary gingiva. (11806482)
2001
36
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space. (10543652)
1999
37
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
38
Ossifying fibroma/osteoma in the proximal tibia of a mature gelding. (9800307)
1998
39
Maxillary sinus ossifying fibroma. (9395021)
1997
40
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
41
Ossifying fibroma of the skull: clinical and therapeutic study. (8191602)
1994
42
Giant ossifying fibroma. Case report on a bimaxillary presentation. (1402053)
1992
43
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
44
Ossifying fibroma of the jaws: a case report. (1765021)
1991
45
Case presentation: ossifying fibroma. (1820513)
1991
46
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
47
Giant ossifying fibroma of the nasal cavity with intracranial extension. (7246283)
1981
48
Ossifying fibroma in a greater kudu. (411210)
1977
49
Ossifying Fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws. (821512)
1976
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Expression patterns in normal tissues for genes affiliated with Ossifying Fibroma

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Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8JAG1, NOTCH1
29.8NOTCH1, NOTCH3
3
Show member pathways
9.8NOTCH1, NOTCH3
49.7BGLAP, RUNX2
59.7BGLAP, RUNX2
6
Show member pathways
Development Notch Signaling Pathway59
Transcription Sin3 and NuRD in transcription regulation59
9.6JAG1, JAG2, NOTCH1
7
Show member pathways
9.6NOTCH1, JAG2, JAG1
89.5JAG1, NOTCH3, NOTCH1
99.4RUNX2, BGLAP, GNAS
109.3NOTCH1, BGLAP, RUNX2
119.3NOTCH1, NOTCH3, GFAP
129.3NOTCH1, NOTCH3, GFAP
13
Show member pathways
Notch signaling pathway37
9.3NOTCH1, NOTCH3, JAG2, JAG1
14
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.3JAG1, JAG2, NOTCH3, NOTCH1
15
Show member pathways
9.3NOTCH1, NOTCH3, JAG2, JAG1
169.0JAG1, JAG2, NOTCH3, NOTCH1, CDC73
178.9NOTCH1, NOTCH3, JAG2, JAG1, RUNX2
18
Show member pathways
8.4GFAP, GNAS, JAG1, JAG2, NOTCH3, NOTCH1
198.2ODAM, JAG1, JAG2, HMMR, NOTCH1

Compounds for genes affiliated with Ossifying Fibroma

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Sources:
44Novoseek, 50PharmGKB, 12DrugBank, 25HMDB, 29IUPHAR
See all sources

Compounds related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1alizarin4410.1BGLAP, RUNX2
2titanium449.9RUNX2, BGLAP
3alendronate44 50 1211.8RUNX2, BGLAP
4eosin449.7MUC1, GFAP
5s 100449.7MUC1, GFAP
6reticulin449.6GFAP, MUC1
7ribonucleic acid449.3MUC1, GNAS, RUNX2
8acth449.2MUC1, GNAS, GFAP
9pge2449.2HMMR, GNAS, BGLAP, RUNX2
10matrigel449.1NOTCH1, MUC1, GFAP
11arginine449.1NOTCH3, GNAS, GFAP, BGLAP
12butyrate448.9RUNX2, GFAP, MUC1
13thymidine44 259.9MUC1, GNAS, GFAP, RUNX2
14alanine448.9GNAS, GFAP, BGLAP, RUNX2
15cyclic amp44 259.9MUC1, GNAS, GFAP, RUNX2
16nitric oxide44 25 1210.8RUNX2, GNAS, MUC1, JAG1, NOTCH1
17cysteine448.7BGLAP, GFAP, GNAS, MUC1, NOTCH3
18dexamethasone44 50 29 1211.6NOTCH1, MUC1, GFAP, BGLAP, RUNX2
19vegf448.6RUNX2, BGLAP, GFAP, MUC1, NOTCH1
20oxygen44 259.6RUNX2, GFAP, GNAS, MUC1, NOTCH1
21threonine448.5NOTCH1, MUC1, GNAS, GFAP
22estrogen448.5RUNX2, BGLAP, GFAP, MUC1, NOTCH1
23retinoic acid44 259.5RUNX2, BGLAP, GFAP, MUC1, NOTCH1
24glutamate448.5GFAP, GNAS, ERCC6, NOTCH1
25lipid448.5RUNX2, GFAP, GNAS, MUC1, NOTCH1
26serine448.2RUNX2, BGLAP, GFAP, GNAS, MUC1, NOTCH1
27tyrosine448.0RUNX2, GFAP, GNAS, MUC1, HMMR, NOTCH1
28calcium44 50 25 1211.0RUNX2, BGLAP, GFAP, GNAS, MUC1, NOTCH3

GO Terms for genes affiliated with Ossifying Fibroma

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Cellular components related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7NOTCH1, NOTCH3, JAG1, ODAM, GNAS, BGLAP
2cytoplasmGO:0057377.0GFAP, GNAS, ODAM, MUC1, HMMR, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:00991210.2NOTCH1, JAG2
2distal tubule developmentGO:07201710.1NOTCH1, JAG1
3negative regulation of stem cell differentiationGO:200073710.1NOTCH1, JAG1
4cardiac septum morphogenesisGO:06041110.1NOTCH1, JAG1
5pulmonary valve morphogenesisGO:00318410.1JAG1, NOTCH1
6Notch signaling involved in heart developmentGO:06131410.1NOTCH1, JAG1
7response to muramyl dipeptideGO:03249510.1NOTCH1, JAG1
8neuronal stem cell maintenanceGO:09715010.1JAG1, NOTCH1
9T cell differentiationGO:03021710.0JAG2, RUNX2
10osteoblast developmentGO:00207610.0BGLAP, RUNX2
11embryonic cranial skeleton morphogenesisGO:0487019.9RUNX2, GNAS
12endochondral ossificationGO:0019589.9GNAS, RUNX2
13embryonic hindlimb morphogenesisGO:0351169.9GNAS, NOTCH1
14negative regulation of neuron differentiationGO:0456659.9NOTCH3, JAG1
15bone developmentGO:0603489.9GNAS, BGLAP
16keratinocyte differentiationGO:0302169.8JAG1, NOTCH1
17forebrain developmentGO:0309009.7NOTCH1, NOTCH3
18regulation of cell migrationGO:0303349.6JAG1, JAG2
19Notch receptor processingGO:0072209.6NOTCH1, NOTCH3, JAG2, JAG1
20transcription initiation from RNA polymerase II promoterGO:0063679.6NOTCH1, NOTCH3, RUNX2
21Notch signaling pathwayGO:0072199.6JAG1, JAG2, NOTCH3, NOTCH1
22odontogenesis of dentin-containing toothGO:0424759.3RUNX2, ODAM, JAG2

Molecular functions related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.6JAG2, JAG1
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.4MUC1, RUNX2
3calcium ion bindingGO:0055098.9NOTCH1, NOTCH3, JAG2, JAG1, BGLAP
4protein bindingGO:0055157.1RUNX2, GNAS, MUC1, JAG1, JAG2, ERCC6

Products for genes affiliated with Ossifying Fibroma

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Sources for Ossifying Fibroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet