MCID: OSS001
MIFTS: 42

Ossifying Fibroma malady

Categories: Cancer diseases, Bone diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 12 14 69
Peripheral Ossifying Fibroma 12 69
Fibroma, Ossifying 42
Fibroma Ossifying 52
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 42 D018214
NCIt 47 C8422
UMLS 69 C0206640

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include bone, testes and bone marrow, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 12.4
2 osteofibrous dysplasia 11.9
3 hyperparathyroidism-jaw tumor syndrome 11.4
4 gigantiform cementoma, familial 11.2
5 fibroma 11.1
6 sinusitis 10.4
7 fibrous dysplasia 10.3
8 aneurysmal bone cysts 10.2
9 aneurysm 10.2
10 kallmann syndrome 6 10.2 MDM2 RASAL1
11 pyogenic granuloma 10.1
12 conventional central osteosarcoma 10.1 GNAS MDM2
13 metachronous osteosarcoma of the bone 10.1 GNAS MDM2
14 hyperparathyroidism 10.1
15 gingivitis 10.1
16 axial osteomalacia 10.0 CDC73 GNAS
17 non-small cell lung cancer, childhood 10.0 JAG1 NOTCH1
18 periodontitis 10.0
19 opiate dependence 10.0 JAG1 NOTCH1
20 functioning pituitary adenoma 9.9 NOTCH1 NOTCH3
21 pineal dysgerminoma 9.9 JAG1 NOTCH1
22 monostotic fibrous dysplasia 9.9
23 mastoiditis 9.9
24 neurofibromatosis 9.9
25 chondrosarcoma 9.9
26 bartonellosis 9.9 NOTCH1 NOTCH3
27 thoracic benign neoplasm 9.8 CDC73 ERCC6 GNAS RASAL1
28 schistosomiasis 9.8 JAG1 NOTCH3
29 testicular germ cell tumor non-seminomatous 9.8 JAG1 NOTCH1
30 buschke-ollendorff syndrome 9.8
31 tuberous sclerosis 9.8
32 fibromatosis 9.8
33 retinoblastoma 9.8
34 florid cemento-osseous dysplasia 9.8
35 giant cell tumor 9.8
36 neurofibromatosis, type 1 9.8
37 lipoblastoma 9.8
38 oculoectodermal syndrome 9.8
39 cellulitis 9.8
40 bilateral retinoblastoma 9.8
41 adamantinoma of long bones 9.8
42 epulis 9.8
43 juxtacortical chondrosarcoma 9.8
44 keratocystic odontogenic tumor 9.8
45 adenoma 9.8
46 osteoblastoma 9.8
47 psammomatous meningioma 9.8
48 parathyroid adenoma 9.8
49 hyperthyroidism 9.8
50 fanconi syndrome 9.8

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 NOTCH3 CDC73 ERCC6 GNAS JAG1 JAG2
2 cellular MP:0005384 10.13 GNAS JAG1 MDM2 NOTCH1 NOTCH3 CDC73
3 hematopoietic system MP:0005397 10.11 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
4 homeostasis/metabolism MP:0005376 10.1 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
5 endocrine/exocrine gland MP:0005379 10.09 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
6 cardiovascular system MP:0005385 10.07 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
7 integument MP:0010771 10.06 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
8 embryo MP:0005380 10.03 CDC73 JAG1 JAG2 MDM2 NOTCH1 NOTCH3
9 immune system MP:0005387 10.02 CDC73 ERCC6 GNAS JAG2 MDM2 NOTCH1
10 mortality/aging MP:0010768 10.01 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
11 hearing/vestibular/ear MP:0005377 10 ERCC6 GNAS JAG1 JAG2 NOTCH1 NOTCH3
12 craniofacial MP:0005382 9.97 GNAS JAG1 JAG2 MDM2 NOTCH1
13 digestive/alimentary MP:0005381 9.97 CDC73 JAG1 JAG2 MDM2 NOTCH1
14 liver/biliary system MP:0005370 9.91 NOTCH1 CDC73 ERCC6 GNAS JAG1 MDM2
15 muscle MP:0005369 9.91 CDC73 ERCC6 GNAS JAG1 MDM2 NOTCH1
16 nervous system MP:0003631 9.86 CDC73 ERCC6 GNAS JAG1 JAG2 MDM2
17 neoplasm MP:0002006 9.72 ERCC6 GNAS MDM2 NOTCH1 NOTCH3
18 renal/urinary system MP:0005367 9.63 CDC73 GNAS JAG1 MDM2 NOTCH1 NOTCH3
19 respiratory system MP:0005388 9.35 CDC73 GNAS JAG2 NOTCH1 NOTCH3
20 skeleton MP:0005390 9.17 ERCC6 GNAS JAG1 JAG2 MDM2 NOTCH1

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

MalaCards organs/tissues related to Ossifying Fibroma:

39
Bone, Testes, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Ossifying Fibroma:

18
The Mouth

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 592)
id Title Authors Year
1
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. ( 27922957 )
2017
2
Conservative Management of Central Cemento-Ossifying Fibroma. ( 27831973 )
2017
3
Orbital ossifying fibroma: A case report. ( 26928888 )
2016
4
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. ( 27311848 )
2016
5
Commentary on: "An update on peripheral ossifying fibroma: case report and literature review". ( 27891559 )
2016
6
Cemento-ossifying fibroma of mandible mimicking complex composite odontome. ( 27797795 )
2016
7
Juvenile psammomatoid ossifying fibroma of the posterior fossa: a case report and review. ( 27468389 )
2016
8
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". ( 27888362 )
2016
9
Nonvascularized Free Transport Distraction Osteogenesis to Reconstruct the Mandibular Defect of a Patient With an Ossifying Fibroma: AA Case Report. ( 27292526 )
2016
10
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). ( 27476108 )
2016
11
Erratum to: An update on peripheral ossifying fibroma: case report and literature review. ( 27822773 )
2016
12
Peripheral ossifying fibroma: A rare case affecting maxillary region. ( 27795650 )
2016
13
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. ( 27134454 )
2016
14
Juvenile Psammomatoid Ossifying Fibroma: Findings on Bone Scan. ( 27405032 )
2016
15
Coverage Root after Removing Peripheral Ossifying Fibroma: 5-Year Follow-Up Case Report. ( 27891263 )
2016
16
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. ( 26962494 )
2016
17
Erratum: Cemento-ossifying fibroma of the jaw. ( 27261511 )
2016
18
Case of the Month: Peripheral Ossifying Fibroma. ( 27476233 )
2016
19
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. ( 27044378 )
2016
20
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. ( 26740351 )
2016
21
Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery? ( 27192645 )
2016
22
Cemento-ossifying fibroma of the jaw. ( 27174452 )
2016
23
Oral Pathology. Common Oral Gingival Lesions. Diagnosis: Peripheral ossifying fibroma. ( 27263144 )
2016
24
Cranial juvenile psammomatoid ossifying fibroma: case report. ( 26588460 )
2016
25
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. ( 27513775 )
2016
26
Endonasal endoscopic resection of ossifying fibroma involving the ethmoid sinus, orbit and anterior skull base: case report and literature review. ( 27196080 )
2016
27
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. ( 27192894 )
2016
28
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. ( 27658992 )
2016
29
Recurrent peripheral cemento-ossifying fibroma. ( 26229278 )
2015
30
Cemento-ossifying fibroma of mandible: An unusual case report and review of literature. ( 26980975 )
2015
31
Percutaneous cryoablation for a symptomatic non-ossifying fibroma. A case report. ( 25533495 )
2015
32
Management of Ossifying Fibroma in a Suspicious Case of Hyperparathyroid-Jaw Tumor Syndrome. ( 26269732 )
2015
33
Ossifying fibroma of the maxilla and tuberous sclerosis complex. ( 25870452 )
2015
34
Management of residual mucogingival defect resulting from the excision of recurrent peripheral ossifying fibroma by periodontal plastic surgical procedure. ( 26604587 )
2015
35
Giant central ossifying fibroma of the maxilla presenting with a pus discharging intra-oral sinus. ( 25738089 )
2015
36
Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina. ( 26811709 )
2015
37
Oral pathology quiz #88. Case Number 4. Peripheral ossifying fibroma. ( 26495674 )
2015
38
Trabecular Variant of Juvenile Aggressive Ossifying Fibroma. ( 26266018 )
2015
39
Ossifying Fibroma in a Patient With Oculocerebrocutaneous (Delleman) Syndrome. ( 25887166 )
2015
40
A pediatric viewpoint on peripheral ossifying fibroma: a case report. ( 25734294 )
2015
41
Ossifying fibroma in the temporomandibular joint: report of an unusual case and treatment perspectives. ( 26188842 )
2015
42
Surgical Management of Ossifying Fibroma in Maxilla: Report of Two Cases. ( 26124613 )
2015
43
Low-grade osteosarcoma arising from cemento-ossifying fibroma: a case report. ( 25741469 )
2015
44
Psammomatoid Juvenile Ossifying Fibroma Involving Upper Jaw: A Rare Case Report. ( 26393222 )
2015
45
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. ( 25649957 )
2015
46
An update on peripheral ossifying fibroma: case report and literature review. ( 26556782 )
2015
47
Maxillo-Mandibular Cemento-ossifying Fibroma: A Rare Case Report. ( 25838714 )
2015
48
Oral Pathology Quiz #87. Case Number 4. Peripheral ossifying fibroma. ( 26242107 )
2015
49
Peripheral ossifying fibroma: A clinicopathologic study of 27 cases and review of the literature with emphasis on histomorphologic features. ( 25810599 )
2015
50
Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: a diagnostic challenge. ( 24591292 )
2015

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
2
Show member pathways
13.41 JAG1 JAG2 MDM2 NOTCH1 NOTCH3 RASAL1
3
Show member pathways
12.59 JAG1 JAG2 NOTCH1 NOTCH3
4
Show member pathways
12.59 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
5
Show member pathways
12.27 JAG1 JAG2 NOTCH1 NOTCH3
6
Show member pathways
12.24 JAG1 JAG2 NOTCH1 NOTCH3
7 12.23 MDM2 NOTCH1 NOTCH3
8
Show member pathways
11.94 JAG1 JAG2 NOTCH1
9
Show member pathways
11.82 JAG1 JAG2 NOTCH1
10 11.79 JAG1 JAG2 NOTCH3
11 11.7 MDM2 NOTCH1 NOTCH3
12 11.61 CDC73 JAG1 JAG2 NOTCH1 NOTCH3
13 11.48 JAG1 NOTCH1 NOTCH3
14 11.17 JAG1 JAG2 NOTCH1
15 11 NOTCH1 NOTCH3
16 10.74 JAG1 NOTCH1
17 10.59 JAG1 JAG2 NOTCH1
18 10.36 JAG1 JAG2 NOTCH1 NOTCH3

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 GNAS JAG1 NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.92 JAG2 NOTCH1 NOTCH3 RASAL1
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.9 CDC73 MDM2 NOTCH1 NOTCH3
3 regulation of cell proliferation GO:0042127 9.77 JAG1 JAG2 NOTCH1
4 regulation of cell migration GO:0030334 9.63 JAG1 JAG2 NOTCH1
5 positive regulation of osteoblast differentiation GO:0045669 9.62 GNAS JAG1
6 cell communication GO:0007154 9.61 JAG1 JAG2
7 protein destabilization GO:0031648 9.61 CDC73 MDM2
8 negative regulation of cell differentiation GO:0045596 9.61 JAG1 NOTCH1 NOTCH3
9 blood vessel remodeling GO:0001974 9.58 JAG1 MDM2
10 neuron fate commitment GO:0048663 9.58 NOTCH1 NOTCH3
11 negative regulation of neuron differentiation GO:0045665 9.58 JAG1 NOTCH1 NOTCH3
12 embryonic hindlimb morphogenesis GO:0035116 9.57 GNAS NOTCH1
13 neuronal stem cell population maintenance GO:0097150 9.56 JAG1 NOTCH1
14 endocardial cushion morphogenesis GO:0003203 9.55 MDM2 NOTCH1
15 negative regulation of stem cell differentiation GO:2000737 9.54 JAG1 NOTCH1
16 response to muramyl dipeptide GO:0032495 9.52 JAG1 NOTCH1
17 atrioventricular valve morphogenesis GO:0003181 9.51 MDM2 NOTCH1
18 pulmonary valve morphogenesis GO:0003184 9.49 JAG1 NOTCH1
19 Notch signaling involved in heart development GO:0061314 9.48 JAG1 NOTCH1
20 Notch signaling pathway GO:0007219 9.46 JAG1 JAG2 NOTCH1 NOTCH3
21 positive regulation of Notch signaling pathway GO:0045747 9.43 JAG1 JAG2 NOTCH1
22 auditory receptor cell fate commitment GO:0009912 9.37 JAG2 NOTCH1
23 distal tubule development GO:0072017 9.32 JAG1 NOTCH1
24 Notch receptor processing GO:0007220 9.13 JAG1 JAG2 NOTCH3
25 cardiac septum morphogenesis GO:0060411 8.8 JAG1 MDM2 NOTCH1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 JAG1 JAG2 NOTCH1 NOTCH3
2 Notch binding GO:0005112 8.8 JAG1 JAG2 NOTCH1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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