MCID: OSS001
MIFTS: 42

Ossifying Fibroma malady

Categories: Cancer diseases, Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

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Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 11 13 67
Peripheral Ossifying Fibroma 11 67
Fibroma, Ossifying 38
 
Fibroma Ossifying 49
Fibro-Osteoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:180
MeSH38 D018214
NCIt44 C8422

Summaries for Ossifying Fibroma

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Disease Ontology:11 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and Development NOTCH1-mediated pathway for NF-KB activity modulation. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are respiratory system and craniofacial.

Related Diseases for Ossifying Fibroma

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Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile ossifying fibroma12.3
2osteofibrous dysplasia11.9
3hyperparathyroidism-jaw tumor syndrome11.4
4gigantiform cementoma, familial11.2
5fibroma11.1
6sinusitis10.4
7fibrous dysplasia10.3
8aneurysmal bone cysts10.2
9aneurysm10.2
10polyarticular onset juvenile idiopathic arthritis10.2MDM2, RASAL1
11bone osteosarcoma10.2GNAS, MDM2
12pyogenic granuloma10.1
13small cell osteogenic sarcoma10.1GNAS, MDM2
14hyperparathyroidism10.1
15gingivitis10.1
16periodontitis10.0
17mirage syndrome9.9JAG1, NOTCH1
18chondrosarcoma9.9
19mastoiditis9.9
20monostotic fibrous dysplasia9.9
21male reproductive organ benign neoplasm9.9CDC73, GNAS
22testicular trophoblastic tumor9.8JAG1, NOTCH1
23buschke-ollendorff syndrome9.8
24retinoblastoma9.8
25neurofibromatosis, type 19.8
26oculoectodermal syndrome9.8
27adamantinoma of long bones9.8
28osteoblastoma9.8
29sphenoid sinusitis9.8
30orbital cellulitis9.8
31chronic apical periodontitis9.8
32giant cell tumor9.8
33cellulitis9.8
34bilateral retinoblastoma9.8
35epulis9.8
36juxtacortical chondrosarcoma9.8
37adenoma9.8
38psammomatous meningioma9.8
39parathyroid adenoma9.8
40hyperthyroidism9.8
41exophthalmos9.8
42periostitis9.8
43fibromatosis9.8
44florid cemento-osseous dysplasia9.8
45lipoblastoma9.8
46keratocystic odontogenic tumor9.8
47trench fever9.7NOTCH1, NOTCH3
48papillary ependymoma9.7JAG1, NOTCH1
49dyserythropoietic anemia, congenital, type ii9.7JAG1, NOTCH1
50chondromalacia9.6JAG1, NOTCH1

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

35
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

17
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

40 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CDC73, GNAS, JAG2, NOTCH1, NOTCH3
2MP:00053828.4GNAS, JAG1, JAG2, MDM2, NOTCH1
3MP:00020068.2ERCC6, GNAS, MDM2, NOTCH1, NOTCH3
4MP:00053708.0CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
5MP:00053817.8CDC73, JAG1, JAG2, MDM2, NOTCH1
6MP:00053777.8ERCC6, GNAS, JAG1, JAG2, NOTCH1, NOTCH3
7MP:00053807.7CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
8MP:00053677.4CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053797.3CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
10MP:00053877.3CDC73, ERCC6, GNAS, JAG2, MDM2, NOTCH1
11MP:00053857.3CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
12MP:00053697.3CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
13MP:00053847.2CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
14MP:00053907.1ERCC6, GNAS, JAG1, JAG2, MDM2, NOTCH1
15MP:00107716.7CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
16MP:00053976.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
17MP:00107686.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
18MP:00053786.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
19MP:00036316.5CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
20MP:00053766.5CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. (27311848)
2016
2
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). (27476108)
2016
3
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. (27513775)
2016
4
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
5
Oxytalan-positive peripheral ossifying fibromas express runt-related transcription factor 2, bone morphogenetic protein-2, and cementum attachment protein. An immunohistochemical study. (25359431)
2015
6
Percutaneous cryoablation for a symptomatic non-ossifying fibroma. A case report. (25533495)
2015
7
Is Computed Tomography an Adequate Imaging Modality for the Evaluation of Juvenile Ossifying Fibroma? A Comparison of 2 Imaging Modalities (Computed Tomography and Magnetic Resonance Imaging). (25911216)
2015
8
Giant central ossifying fibroma of the maxilla presenting with a pus discharging intra-oral sinus. (25738089)
2015
9
Retrospective Analysis of Ossifying Fibroma of Jaw Bones Over a Period of 10 Years with Literature Review. (26225029)
2014
10
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
11
Huge ossifying fibroma of the maxilla. (25018610)
2014
12
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
13
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
14
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
15
Peripheral ossifying fibroma. (24174733)
2013
16
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
17
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
18
Asymptomatic ossifying fibroma of the mandible: a case presentation. (22536589)
2012
19
Peripheral Ossifying fibroma: a clinical report. (23097830)
2012
20
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
21
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
22
Peripheral cemento-ossifying fibroma--a case report. (21356015)
2011
23
Juvenile central ossifying fibroma of the mandible: a case report. (20920702)
2010
24
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
25
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
26
Juvenile aggressive ossifying fibroma of the maxilla. (19841549)
2009
27
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
28
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
29
Endoscopic resection of large sinonasal ossifying fibroma. (15635583)
2005
30
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
31
Ossifying fibroma of the skull: interactive image-guided minimally invasive localization and resection. (15346031)
2004
32
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
33
Cemento-ossifying fibroma and benign cementoblastoma. (10587273)
1999
34
The natural course of an ossifying fibroma. A case report. (10609748)
1999
35
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
36
Maxillary sinus ossifying fibroma. (9395021)
1997
37
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
38
Massive cemento-ossifying fibroma: case report. (9584797)
1996
39
Non-ossifying fibroma of the spine. (24057475)
1996
40
Central ossifying fibroma. (8060568)
1993
41
Ossifying fibroma of the jaws: a case report. (1765021)
1991
42
Ossifying fibroma in the sylvian fissure: case report. (1870672)
1991
43
Ossifying fibroma of the long bones. Radiological diagnosis, differential diagnosis and management implications. (2061274)
1991
44
Periosteal ossifying fibroma of the palate. (6596423)
1984
45
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
46
Giantiform ossifying fibroma of maxillary bone. (409799)
1977
47
Cemento-ossifying fibroma of the mandible: report of a case. (1055193)
1975
48
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
49
Ossifying fibroma of mandible with a case report. (4197396)
1973
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.1NOTCH1, NOTCH3
2
Show member pathways
8.9JAG1, JAG2, NOTCH1
3
Show member pathways
8.9JAG1, JAG2, NOTCH1
48.9JAG1, JAG2, NOTCH1
58.7MDM2, NOTCH1, NOTCH3
68.7MDM2, NOTCH1, NOTCH3
7
Show member pathways
8.5JAG1, NOTCH1, NOTCH3
8
Show member pathways
8.5JAG1, JAG2, MDM2, NOTCH1
9
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
10
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
117.8CDC73, JAG1, JAG2, NOTCH1, NOTCH3
12
Show member pathways
6.6CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

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Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junctionGO:00059129.8JAG1, NOTCH1
2plasma membraneGO:00058866.9GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:000991210.2JAG2, NOTCH1
2protein destabilizationGO:003164810.1CDC73, MDM2
3endocardial cushion morphogenesisGO:000320310.1MDM2, NOTCH1
4embryonic hindlimb morphogenesisGO:003511610.1GNAS, NOTCH1
5distal tubule developmentGO:007201710.0JAG1, NOTCH1
6atrioventricular valve morphogenesisGO:000318110.0MDM2, NOTCH1
7positive regulation of osteoblast differentiationGO:004566910.0GNAS, JAG1
8pulmonary valve morphogenesisGO:00031849.9JAG1, NOTCH1
9response to muramyl dipeptideGO:00324959.9JAG1, NOTCH1
10negative regulation of stem cell differentiationGO:20007379.9JAG1, NOTCH1
11neuron fate commitmentGO:00486639.7NOTCH1, NOTCH3
12blood vessel remodelingGO:00019749.7JAG1, MDM2
13neuronal stem cell population maintenanceGO:00971509.7JAG1, NOTCH1
14Notch signaling involved in heart developmentGO:00613149.6JAG1, NOTCH1
15cardiac septum morphogenesisGO:00604119.3JAG1, MDM2, NOTCH1
16positive regulation of Notch signaling pathwayGO:00457479.2JAG1, JAG2, NOTCH1
17regulation of cell proliferationGO:00421279.0JAG1, JAG2, NOTCH1
18negative regulation of neuron differentiationGO:00456658.9JAG1, NOTCH1, NOTCH3
19Notch receptor processingGO:00072208.9JAG1, JAG2, NOTCH3
20negative regulation of cell differentiationGO:00455968.9JAG1, NOTCH1, NOTCH3
21regulation of cell migrationGO:00303348.6JAG1, JAG2, NOTCH1
22negative regulation of transcription from RNA polymerase II promoterGO:00001228.4CDC73, MDM2, NOTCH1, NOTCH3
23Notch signaling pathwayGO:00072198.3JAG1, JAG2, NOTCH1, NOTCH3

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051128.8JAG1, JAG2, NOTCH1
2calcium ion bindingGO:00055098.1JAG1, JAG2, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet