MCID: OSS001
MIFTS: 50

Ossifying Fibroma malady

Bone diseases category

Summaries for Ossifying Fibroma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards: Ossifying Fibroma, also known as fibroma ossifying, is related to fibrous dysplasia and osteosarcoma. An important gene associated with Ossifying Fibroma is CDC73 (cell division cycle 73), and among its related pathways are Post-transcriptional Silencing By Small RNAs and Pre-NOTCH Processing in Golgi. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Wikipedia:63 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

Aliases & Classifications for Ossifying Fibroma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

ossifying fibroma 8 10 60
fibroma ossifying 44
fibro-osteoma 8


External Ids:

Disease Ontology8 DOID:180
MeSH34 D018214
NCIt39 C8422

Related Diseases for Ossifying Fibroma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia31.0GNAS, RUNX2, BGLAP
2osteosarcoma30.6NOTCH1, RUNX2, BGLAP
3osteofibrous dysplasia30.5GNAS, BGLAP
4hyperparathyroidism30.5CDC73, BGLAP
5chondrosarcoma30.4MUC1, RUNX2
6psammomatous meningioma30.1ERCC6
7parathyroid adenoma30.1CDC73, GNAS
8adenoma30.1GNAS, MUC1, CDC73
9bone fracture10.4
10gingivitis10.4
11meningioma10.4
12neurofibromatosis10.3
13periodontitis10.3
14osteoblastoma10.1
15bilateral retinoblastoma10.1
16chronic apical periodontitis10.1
17orbital cellulitis10.1
18primary hyperparathyroidism10.1
19cellulitis10.1
20exophthalmos10.1
21fanconi syndrome10.1
22adenomatoid tumor10.1
23juxtacortical chondrosarcoma10.1
24orbital cyst10.1
25epulis10.1
26giant cell tumor10.1
27hyperthyroidism10.1
28long bone adamantinoma10.1
29periostitis10.1
30retinoblastoma10.1
31skull base meningioma10.1
32sphenoid sinusitis10.1
33clear cell ependymoma10.0MUC1
34thyroid adenoma10.0GNAS
35sarcoma10.0MUC1
36craniosynostosis10.0RUNX2
37hypertension10.0NOTCH1
38choroid plexus papilloma10.0GFAP
39hyperphosphatemia10.0GNAS, RUNX2
40wermer syndrome10.0CDC73
41lung cancer10.0ERCC6, MUC1
42anaplastic ependymoma10.0MUC1, GFAP
43thyroid cancer10.0BGLAP, GNAS
44pseudohypoparathyroidism type 1b10.0BGLAP, GNAS
45ependymoma10.0GFAP, MUC1
46osteitis fibrosa10.0GNAS, BGLAP
47adenocarcinoma10.0NOTCH1, MUC1
48ovarian cancer10.0MUC1, NOTCH1
49progressive osseous heteroplasia10.0BGLAP, RUNX2, GNAS
50cleidocranial dysplasia10.0RUNX2, BGLAP

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Clinical Features for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ossifying Fibroma

Drug clinical trials:

Search ClinicalTrials for Ossifying Fibroma

Search NIH Clinical Center for Ossifying Fibroma

Search CenterWatch for Ossifying Fibroma

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Ossifying Fibroma:

32
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

14
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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36MGI
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Publications for Ossifying Fibroma

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50PubMed
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Articles related to Ossifying Fibroma:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
2
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
3
Recurrent ossifying fibroma of the sphenoid bone 26 years after primary surgical excision; a case report and review of the literature. (23192835)
2013
4
Peripheral cemento-ossifying fibroma: A case report with review of literature. (24303483)
2013
5
Retraction. A rare occurrence of peripheral ossifying fibroma in the first decade of life and its management. (23975942)
2013
6
Juvenile psammomatoid ossifying fibroma with visual disturbance: a case report with imaging features. (21699600)
2013
7
A huge cemento-ossifying fibroma of paranasal sinus: a case report. (23297525)
2012
8
Psammomatoid juvenile aggressive ossifying fibroma of mandible. (23251058)
2012
9
Peripheral ossifying fibroma. (22337469)
2012
10
Interrelationship between pyogenic granuloma and peripheral ossifying fibroma: a case report. (22947840)
2012
11
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
12
Juvenile psammomatoid ossifying fibroma of the orbit and paranasal sinuses. A case report. (21826543)
2011
13
Surgical resection of a huge cemento-ossifying fibroma in skull base by intraoral approach. (21403573)
2011
14
Rapidly maturing juvenile ossifying fibroma: a case report. (21346088)
2011
15
General practitioner's radiology case 96. Juvenile ossifying fibroma. (23477273)
2011
16
Juvenile aggressive psammomatoid ossifying fibroma. (19925994)
2009
17
Ossifying fibroma in a Hong Kong community: the clinical and radiological features and outcomes of treatment. (20026708)
2009
18
Ossifying fibroma: a rare cause of orbital inflammation. (18356714)
2008
19
Mandibular ossifying fibroma in a dog. (18424835)
2008
20
Central ossifying fibroma: an analysis of 20 cases and review of the literature. (17333999)
2007
21
Psammomatoid ossifying fibroma. (17186371)
2007
22
Juvenile ossifying fibroma of the maxilla. (17018252)
2007
23
Ossifying fibroma of the mandible with primary hyperparathyroidism due to non-familial parathyroid adenoma. (17134536)
2007
24
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
25
Ossifying fibroma of the skull: interactive image-guided minimally invasive localization and resection. (15346031)
2004
26
General practitioner's radiology case 26. Ossifying fibroma (juvenile type).. (15624877)
2004
27
Cemento-ossifying fibroma of the ethmoidal sinus in a child presenting with isolated pain in the nasal region. (15167231)
2004
28
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
29
Juvenile aggressive cemento-ossifying fibroma. A case report. (12800760)
2003
30
Excision and repair of the peripheral ossifying fibroma: a report of 3 cases. (11495143)
2001
31
A hypervascular ossifying fibroma of the tibia on Tc-99m MDP three-phase bone scintigraphy. (11290909)
2001
32
Evaluation of an ossifying fibroma using three-dimensional computed tomography. (11641734)
2001
33
Ossifying fibroma of the temporal bone. (11535150)
2001
34
Ossifying fibroma of the temporal bone. (10759001)
2000
35
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
36
Familial isolated hyperparathyroidism due to multiple adenomas associated with ossifying jaw fibroma and multiple uterine adenomyomatous polyps. (9625369)
1998
37
Cemento-ossifying fibroma of the petromastoid region: case report and review of the literature. (9102442)
1997
38
The use of megavoltage radiation to treat juvenile mandibular ossifying fibroma in a horse. (8939336)
1996
39
Ossifying fibroma of the sella turcica. (1418763)
1992
40
Massive ossifying fibroma of the temporal bone. (2122383)
1990
41
Ossifying fibroma of the maxillary sinus: a case report. (2782841)
1989
42
Giant ossifying fibroma: a clinicopathologic study of 8 tumors. (2607471)
1989
43
Psammomatoid ossifying fibroma. (3753286)
1986
44
Ossifying fibroma: a clinicopathologic study of sixty-four cases. (3864113)
1985
45
Pathologic quiz case 1. Fibrous dysplasia of bone and ossifying fibroma. (6849667)
1983
46
Intranuclear vermicellar bodies in human osteosarcoma and ossifying fibroma cells. (6577007)
1983
47
Cemento-ossifying fibroma of the ethmoidal sinus manifesting as proptosis. (7092025)
1982
48
Maxillary ossifying fibroma. (822113)
1976
49
Ossifying fibroma of mandible with a case report. (4197396)
1973
50
ANEURYSMAL BONE CYSTS. A REPORT OF SIX CASES, INCLUDING A FATAL CASE ASSOCIATED WITH A NON-OSSIFYING FIBROMA. (14346534)
1965

Genetic Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ossifying Fibroma

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Pathways for genes affiliated with Ossifying Fibroma

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8NOTCH1, NOTCH3
2
Hide members
9.8NOTCH1, NOTCH3
39.8NOTCH1, NOTCH3
49.5NOTCH1, NOTCH3, GFAP
5
Hide members
9.5JAG2, JAG1, NOTCH1
69.4NOTCH1, NOTCH3, JAG1
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.2GNAS, RUNX2, BGLAP
8
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
9
Hide members
9.1JAG2, JAG1, NOTCH3, NOTCH1
10
Hide members
9.1JAG2, JAG1, NOTCH3, NOTCH1
119.1JAG2, JAG1, NOTCH3, NOTCH1
12
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
13
Hide members
9.1NOTCH1, NOTCH3, JAG1, JAG2
149.0BGLAP, RUNX2, NOTCH1
158.9JAG2, JAG1, CDC73, NOTCH3, NOTCH1
168.9NOTCH1, NOTCH3, JAG1, JAG2, RUNX2
17
Hide members
8.0GNAS, PPP1CC, JAG2, JAG1, GFAP, NOTCH3

Compounds for genes affiliated with Ossifying Fibroma

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1eosin4410.2GFAP, MUC1
2s 1004410.2MUC1, GFAP
3reticulin449.9GFAP, MUC1
4alizarin449.6RUNX2, BGLAP
5thymidine44 2410.5GFAP, MUC1, GNAS, RUNX2
6glycogen44 2410.1PPP1CC, MUC1, GFAP, NOTCH1
7lipid448.8RUNX2, GNAS, APOF, MUC1, GFAP, NOTCH1
8nitric oxide44 11 2410.7RUNX2, GNAS, JAG1, MUC1, NOTCH1
9dexamethasone44 49 28 1111.7BGLAP, RUNX2, MUC1, GFAP, NOTCH1
10vegf448.5BGLAP, RUNX2, MUC1, GFAP, NOTCH1
11calcium44 49 11 2410.5BGLAP, RUNX2, GNAS, PPP1CC, MUC1, GFAP

GO Terms for genes affiliated with Ossifying Fibroma

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16Gene Ontology
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Cellular components related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3NOTCH1, NOTCH3, MUC1, JAG1, APOF, GNAS

Biological processes related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:00991210.0NOTCH1, JAG2
2distal tubule developmentGO:07201710.0NOTCH1, JAG1
3negative regulation of stem cell differentiationGO:200073710.0NOTCH1, JAG1
4endochondral ossificationGO:00195810.0GNAS, RUNX2
5cardiac septum morphogenesisGO:0604119.9NOTCH1, JAG1
6pulmonary valve morphogenesisGO:0031849.9NOTCH1, JAG1
7Notch signaling involved in heart developmentGO:0613149.8NOTCH1, JAG1
8response to muramyl dipeptideGO:0324959.8JAG1, NOTCH1
9neuronal stem cell maintenanceGO:0971509.7NOTCH1, JAG1
10odontogenesis of dentin-containing toothGO:0424759.6ODAM, RUNX2, JAG2
11Notch receptor processingGO:0072209.4NOTCH1, NOTCH3, JAG1, JAG2
12Notch signaling pathwayGO:0072199.4JAG2, JAG1, NOTCH3, NOTCH1
13osteoblast developmentGO:0020769.1RUNX2, BGLAP

Molecular functions related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.9JAG1, JAG2
2calcium ion bindingGO:0055098.0NOTCH1, NOTCH3, JAG1, JAG2, BGLAP

Products for genes affiliated with Ossifying Fibroma

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  • Antibodies
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Sources for Ossifying Fibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet