MCID: OSS001
MIFTS: 42

Ossifying Fibroma malady

Categories: Cancer diseases, Bone diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

About this section

Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 11 13 68
Peripheral Ossifying Fibroma 11 68
Fibroma, Ossifying 39
 
Fibroma Ossifying 50
Fibro-Osteoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:180
MeSH39 D018214
NCIt45 C8422

Summaries for Ossifying Fibroma

About this section
Disease Ontology:11 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits and Dorso-ventral axis formation. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are craniofacial and digestive/alimentary.

Related Diseases for Ossifying Fibroma

About this section

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile ossifying fibroma12.4
2osteofibrous dysplasia11.9
3hyperparathyroidism-jaw tumor syndrome11.4
4gigantiform cementoma, familial11.2
5fibroma11.1
6sinusitis10.4
7fibrous dysplasia10.3
8aneurysmal bone cysts10.2
9aneurysm10.2
10kallmann syndrome 610.2MDM2, RASAL1
11pyogenic granuloma10.1
12conventional central osteosarcoma10.1GNAS, MDM2
13metachronous osteosarcoma of the bone10.1GNAS, MDM2
14hyperparathyroidism10.1
15gingivitis10.1
16axial osteomalacia10.0CDC73, GNAS
17non-small cell lung cancer, childhood10.0JAG1, NOTCH1
18periodontitis10.0
19opiate dependence10.0JAG1, NOTCH1
20functioning pituitary adenoma9.9NOTCH1, NOTCH3
21pineal dysgerminoma9.9JAG1, NOTCH1
22chondrosarcoma9.9
23mastoiditis9.9
24neurofibromatosis9.9
25monostotic fibrous dysplasia9.9
26bartonellosis9.9NOTCH1, NOTCH3
27thoracic benign neoplasm9.8CDC73, ERCC6, GNAS, RASAL1
28schistosomiasis9.8JAG1, NOTCH3
29testicular germ cell tumor non-seminomatous9.8JAG1, NOTCH1
30buschke-ollendorff syndrome9.8
31retinoblastoma9.8
32neurofibromatosis, type 19.8
33oculoectodermal syndrome9.8
34adamantinoma of long bones9.8
35osteoblastoma9.8
36fanconi syndrome9.8
37sphenoid sinusitis9.8
38orbital cellulitis9.8
39chronic apical periodontitis9.8
40tuberous sclerosis9.8
41giant cell tumor9.8
42cellulitis9.8
43bilateral retinoblastoma9.8
44epulis9.8
45juxtacortical chondrosarcoma9.8
46adenoma9.8
47psammomatous meningioma9.8
48parathyroid adenoma9.8
49hyperthyroidism9.8
50exophthalmos9.8

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms & Phenotypes for Ossifying Fibroma

About this section

MGI Mouse Phenotypes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.6GNAS, JAG1, JAG2, MDM2, NOTCH1
2MP:00053818.3CDC73, JAG1, JAG2, MDM2, NOTCH1
3MP:00020068.2ERCC6, GNAS, MDM2, NOTCH1, NOTCH3
4MP:00053888.2CDC73, GNAS, JAG2, NOTCH1, NOTCH3
5MP:00053807.7CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
6MP:00053677.7CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
7MP:00053777.6ERCC6, GNAS, JAG1, JAG2, NOTCH1, NOTCH3
8MP:00053857.5CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053707.4CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
10MP:00053877.3CDC73, ERCC6, GNAS, JAG2, MDM2, NOTCH1
11MP:00053847.1CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
12MP:00053697.0CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
13MP:00053907.0ERCC6, GNAS, JAG1, JAG2, MDM2, NOTCH1
14MP:00053797.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
15MP:00053766.7CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
16MP:00107686.7CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
17MP:00053786.7CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
18MP:00107716.4CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
19MP:00036316.4CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
20MP:00053976.3CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2

Drugs & Therapeutics for Ossifying Fibroma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

About this section

Anatomical Context for Ossifying Fibroma

About this section

MalaCards organs/tissues related to Ossifying Fibroma:

36
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

17
The mouth

Publications for Ossifying Fibroma

About this section

Articles related to Ossifying Fibroma:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. (27922957)
2017
2
Conservative Management of Central Cemento-Ossifying Fibroma. (27831973)
2017
3
Orbital ossifying fibroma: A case report. (26928888)
2016
4
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. (27311848)
2016
5
Commentary on: "An update on peripheral ossifying fibroma: case report and literature review". (27891559)
2016
6
Cemento-ossifying fibroma of mandible mimicking complex composite odontome. (27797795)
2016
7
Juvenile psammomatoid ossifying fibroma of the posterior fossa: a case report and review. (27468389)
2016
8
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". (27888362)
2016
9
Nonvascularized Free Transport Distraction Osteogenesis to Reconstruct the Mandibular Defect of a Patient With an Ossifying Fibroma: AA Case Report. (27292526)
2016
10
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). (27476108)
2016
11
Erratum to: An update on peripheral ossifying fibroma: case report and literature review. (27822773)
2016
12
Peripheral ossifying fibroma: A rare case affecting maxillary region. (27795650)
2016
13
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. (27134454)
2016
14
Juvenile Psammomatoid Ossifying Fibroma: Findings on Bone Scan. (27405032)
2016
15
Coverage Root after Removing Peripheral Ossifying Fibroma: 5-Year Follow-Up Case Report. (27891263)
2016
16
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. (26962494)
2016
17
Erratum: Cemento-ossifying fibroma of the jaw. (27261511)
2016
18
Case of the Month: Peripheral Ossifying Fibroma. (27476233)
2016
19
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. (27044378)
2016
20
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. (26740351)
2016
21
Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery? (27192645)
2016
22
Cemento-ossifying fibroma of the jaw. (27174452)
2016
23
Oral Pathology. Common Oral Gingival Lesions. Diagnosis: Peripheral ossifying fibroma. (27263144)
2016
24
Cranial juvenile psammomatoid ossifying fibroma: case report. (26588460)
2016
25
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. (27513775)
2016
26
Endonasal endoscopic resection of ossifying fibroma involving the ethmoid sinus, orbit and anterior skull base: case report and literature review. (27196080)
2016
27
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. (27192894)
2016
28
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. (27658992)
2016
29
Recurrent peripheral cemento-ossifying fibroma. (26229278)
2015
30
Cemento-ossifying fibroma of mandible: An unusual case report and review of literature. (26980975)
2015
31
Percutaneous cryoablation for a symptomatic non-ossifying fibroma. A case report. (25533495)
2015
32
Management of Ossifying Fibroma in a Suspicious Case of Hyperparathyroid-Jaw Tumor Syndrome. (26269732)
2015
33
Ossifying fibroma of the maxilla and tuberous sclerosis complex. (25870452)
2015
34
Management of residual mucogingival defect resulting from the excision of recurrent peripheral ossifying fibroma by periodontal plastic surgical procedure. (26604587)
2015
35
Giant central ossifying fibroma of the maxilla presenting with a pus discharging intra-oral sinus. (25738089)
2015
36
Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina. (26811709)
2015
37
Oral pathology quiz #88. Case Number 4. Peripheral ossifying fibroma. (26495674)
2015
38
Trabecular Variant of Juvenile Aggressive Ossifying Fibroma. (26266018)
2015
39
Ossifying Fibroma in a Patient With Oculocerebrocutaneous (Delleman) Syndrome. (25887166)
2015
40
A pediatric viewpoint on peripheral ossifying fibroma: a case report. (25734294)
2015
41
Ossifying fibroma in the temporomandibular joint: report of an unusual case and treatment perspectives. (26188842)
2015
42
Surgical Management of Ossifying Fibroma in Maxilla: Report of Two Cases. (26124613)
2015
43
Low-grade osteosarcoma arising from cemento-ossifying fibroma: a case report. (25741469)
2015
44
Psammomatoid Juvenile Ossifying Fibroma Involving Upper Jaw: A Rare Case Report. (26393222)
2015
45
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
46
An update on peripheral ossifying fibroma: case report and literature review. (26556782)
2015
47
Maxillo-Mandibular Cemento-ossifying Fibroma: A Rare Case Report. (25838714)
2015
48
Oral Pathology Quiz #87. Case Number 4. Peripheral ossifying fibroma. (26242107)
2015
49
Peripheral ossifying fibroma: A clinicopathologic study of 27 cases and review of the literature with emphasis on histomorphologic features. (25810599)
2015
50
Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: a diagnostic challenge. (24591292)
2015

Variations for Ossifying Fibroma

About this section

Expression for genes affiliated with Ossifying Fibroma

About this section
Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

About this section

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.3JAG1, NOTCH1
29.1NOTCH1, NOTCH3
3
Show member pathways
8.9JAG1, JAG2, NOTCH1
48.9JAG1, JAG2, NOTCH1
58.9JAG1, JAG2, NOTCH1
6
Show member pathways
8.9JAG1, JAG2, NOTCH1
78.7MDM2, NOTCH1, NOTCH3
88.7MDM2, NOTCH1, NOTCH3
98.6JAG1, JAG2, NOTCH3
10
Show member pathways
8.5JAG1, NOTCH1, NOTCH3
11
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
128.1JAG1, JAG2, NOTCH1, NOTCH3
13
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
14
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
157.8CDC73, JAG1, JAG2, NOTCH1, NOTCH3
16
Show member pathways
7.3JAG1, JAG2, MDM2, NOTCH1, NOTCH3, RASAL1
17
Show member pathways
7.3GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
18
Show member pathways
6.6CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

About this section

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.0GNAS, JAG1, NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1protein destabilizationGO:003164810.3CDC73, MDM2
2embryonic hindlimb morphogenesisGO:003511610.3GNAS, NOTCH1
3auditory receptor cell fate commitmentGO:000991210.3JAG2, NOTCH1
4atrioventricular valve morphogenesisGO:000318110.3MDM2, NOTCH1
5endocardial cushion morphogenesisGO:000320310.2MDM2, NOTCH1
6cell communicationGO:000715410.2JAG1, JAG2
7blood vessel remodelingGO:000197410.2JAG1, MDM2
8positive regulation of osteoblast differentiationGO:004566910.1GNAS, JAG1
9distal tubule developmentGO:007201710.1JAG1, NOTCH1
10negative regulation of stem cell differentiationGO:200073710.1JAG1, NOTCH1
11neuronal stem cell population maintenanceGO:009715010.0JAG1, NOTCH1
12Notch signaling involved in heart developmentGO:006131410.0JAG1, NOTCH1
13pulmonary valve morphogenesisGO:000318410.0JAG1, NOTCH1
14neuron fate commitmentGO:00486639.8NOTCH1, NOTCH3
15cardiac septum morphogenesisGO:00604119.6JAG1, MDM2, NOTCH1
16positive regulation of Notch signaling pathwayGO:00457479.6JAG1, JAG2, NOTCH1
17regulation of cell migrationGO:00303349.5JAG1, JAG2, NOTCH1
18response to muramyl dipeptideGO:00324959.3JAG1, NOTCH1
19Notch receptor processingGO:00072209.3JAG1, JAG2, NOTCH3
20negative regulation of cell differentiationGO:00455969.2JAG1, NOTCH1, NOTCH3
21negative regulation of neuron differentiationGO:00456659.2JAG1, NOTCH1, NOTCH3
22regulation of cell proliferationGO:00421279.2JAG1, JAG2, NOTCH1
23cell differentiationGO:00301549.1JAG2, NOTCH1, NOTCH3, RASAL1
24negative regulation of transcription from RNA polymerase II promoterGO:00001229.0CDC73, MDM2, NOTCH1, NOTCH3
25Notch signaling pathwayGO:00072198.7JAG1, JAG2, NOTCH1, NOTCH3

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051128.9JAG1, JAG2, NOTCH1
2calcium ion bindingGO:00055098.4JAG1, JAG2, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet