MCID: OSS001
MIFTS: 42

Ossifying Fibroma malady

Genetic diseases, Cancer diseases, Oral diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Ossifying Fibroma

About this section
Sources:
10Disease Ontology, 12DISEASES, 65UMLS, 47Novoseek, 36MeSH, 42NCIt, 59SNOMED-CT
See all sources

Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 10 12 65
Fibroma, Ossifying 36
 
Fibroma Ossifying 47
Fibro-Osteoma 10


Classifications:



External Ids:

Disease Ontology10 DOID:180
NCIt42 C8422
MeSH36 D018214

Summaries for Ossifying Fibroma

About this section
Disease Ontology:10 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as fibroma, ossifying, is related to fibroma and juvenile ossifying fibroma. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and Development NOTCH1-mediated pathway for NF-KB activity modulation. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Related Diseases for Ossifying Fibroma

About this section

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma Familial Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma11.6
2juvenile ossifying fibroma11.1
3sinusitis10.8
4fibrous dysplasia10.8
5aneurysmal bone cysts10.7
6aneurysm10.7
7osteofibrous dysplasia10.6
8pyogenic granuloma10.6
9hyperparathyroidism10.5
10familial ossifying fibroma10.5
11gingivitis10.4
12hyperparathyroidism-jaw tumor syndrome10.4
13chondrosarcoma10.4
14neurofibromatosis10.4
15mastoiditis10.4
16periodontitis10.4
17monostotic fibrous dysplasia10.4
18buschke-ollendorff syndrome10.2
19retinoblastoma10.2
20neurofibromatosis, type 110.2
21osteoblastoma10.2
22fanconi syndrome10.2
23tuberous sclerosis10.2
24primary hyperparathyroidism10.2
25orbital cellulitis10.2
26chronic apical periodontitis10.2
27exophthalmos10.2
28psammomatous meningioma10.2
29juxtacortical chondrosarcoma10.2
30bilateral retinoblastoma10.2
31adenoma10.2
32cellulitis10.2
33epulis10.2
34giant cell tumor10.2
35hyperthyroidism10.2
36parathyroid adenoma10.2
37periostitis10.2
38sphenoid sinusitis10.2
39fibromatosis10.2
40florid cemento-osseous dysplasia10.2
41lipoblastoma10.2
42familial parathyroid adenoma10.2
43worth's syndrome10.1CDC73, GNAS
44multiple endocrine neoplasia 110.1CDC73, GNAS
45non 24 hour sleep wake disorder10.0JAG1, NOTCH1
46duodenogastric reflux10.0JAG1, NOTCH1
47tolosa-hunt syndrome10.0JAG1, NOTCH1
48chorioretinitis10.0NOTCH1, NOTCH3
49cell type cancer9.9CDC73, GNAS
50macrocephaly, alopecia, cutis laxa, and scoliosis9.9JAG1, NOTCH1

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

About this section

Drugs & Therapeutics for Ossifying Fibroma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: Fibroma, Ossifying

Genetic Tests for Ossifying Fibroma

About this section

Anatomical Context for Ossifying Fibroma

About this section

MalaCards organs/tissues related to Ossifying Fibroma:

33
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

16
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

About this section

MGI Mouse Phenotypes related to Ossifying Fibroma:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.2GNAS, JAG1, JAG2, NOTCH1
2MP:00053718.8ERCC6, GNAS, JAG2, KDM7A
3MP:00053778.5GNAS, JAG1, JAG2, NOTCH1, NOTCH3
4MP:00053678.5CDC73, GNAS, JAG1, NOTCH1, NOTCH3
5MP:00053858.5CDC73, GNAS, JAG1, NOTCH1, NOTCH3
6MP:00053888.4CDC73, GNAS, JAG2, NOTCH1, NOTCH3
7MP:00053808.4CDC73, JAG1, JAG2, NOTCH1, NOTCH3
8MP:00053708.3CDC73, ERCC6, GNAS, JAG1, NOTCH1
9MP:00053847.7CDC73, ERCC6, GNAS, JAG1, NOTCH1, NOTCH3
10MP:00053697.7CDC73, ERCC6, GNAS, JAG1, NOTCH1, NOTCH3
11MP:00053797.6CDC73, GNAS, JAG1, KDM7A, NOTCH1, NOTCH3
12MP:00053787.6CDC73, ERCC6, GNAS, JAG1, NOTCH1, NOTCH3
13MP:00053877.3CDC73, ERCC6, GNAS, JAG2, NOTCH1, NOTCH3
14MP:00053907.2ERCC6, GNAS, JAG1, JAG2, KDM7A, NOTCH1
15MP:00036317.0CDC73, ERCC6, GNAS, JAG1, JAG2, NOTCH1
16MP:00053766.9CDC73, ERCC6, GNAS, JAG1, JAG2, NOTCH1
17MP:00107686.6CDC73, ERCC6, GNAS, JAG1, JAG2, KDM7A
18MP:00053976.6CDC73, ERCC6, GNAS, JAG1, JAG2, NOTCH1
19MP:00107716.6CDC73, ERCC6, GNAS, JAG1, JAG2, KDM7A

Publications for Ossifying Fibroma

About this section

Articles related to Ossifying Fibroma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Juvenile ossifying fibroma of the maxilla: a case report. (25838672)
2015
2
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
3
An unusual presentation of peripheral ossifying fibroma in an elderly man. (24925549)
2014
4
Juvenile ossifying fibroma of the middle turbinate. (25075725)
2014
5
Ossifying fibroma in the sinonasal tract: a rare case report. (25302205)
2014
6
Retrospective Analysis of Ossifying Fibroma of Jaw Bones Over a Period of 10 Years with Literature Review. (26225029)
2014
7
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
8
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
9
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
10
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
11
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
12
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
13
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
14
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
15
Placement of implants in an ossifying fibroma defect obliterated with demineralized, freeze-dried bone allograft and Plasma-rich growth factor. (23633812)
2012
16
Trabecular and psammomatoid juvenile ossifying fibroma of the skull base mimicking psammomatoid meningioma. (20953744)
2011
17
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
18
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
19
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
20
A case report of cemento-ossifying fibroma. (22190782)
2010
21
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
22
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
23
Giant ossifying fibroma complicated by mucocele of sphenoid sinus--case report. (19105117)
2008
24
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
25
Case of the month: peripheral ossifying fibroma. (18546612)
2008
26
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
27
Ossifying fibroma of long bones in adults: a case report. (17260623)
2006
28
Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). (16407489)
2006
29
Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. (16632273)
2006
30
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
31
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
32
Ossifying fibroma of the jaw. (15372914)
2004
33
Psammomatoid ossifying fibroma of the ethmoid. (12784573)
2003
34
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
35
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
36
Peripheral ossifying fibroma of the maxillary gingiva. (11806482)
2001
37
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space. (10543652)
1999
38
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
39
Maxillary sinus ossifying fibroma. (9395021)
1997
40
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
41
Ossifying fibroma of the skull: clinical and therapeutic study. (8191602)
1994
42
Giant ossifying fibroma. Case report on a bimaxillary presentation. (1402053)
1992
43
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
44
Ossifying fibroma of the jaws: a case report. (1765021)
1991
45
Case presentation: ossifying fibroma. (1820513)
1991
46
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
47
Giant ossifying fibroma of the nasal cavity with intracranial extension. (7246283)
1981
48
Ossifying fibroma in a greater kudu. (411210)
1977
49
Ossifying Fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws. (821512)
1976
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

About this section

Expression for genes affiliated with Ossifying Fibroma

About this section
Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

About this section

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NOTCH1, NOTCH3
2
Show member pathways
9.1JAG1, JAG2, NOTCH1
3
Show member pathways
9.1JAG1, JAG2, NOTCH1
4
Angiogenesis (CST)
Show member pathways
8.9JAG1, JAG2, NOTCH1
5
Notch signaling pathway (Pathway Interaction Database)
Show member pathways
8.5JAG1, JAG2, NOTCH1
68.5JAG1, JAG2, NOTCH1, NOTCH3
7
Show member pathways
8.5JAG1, JAG2, NOTCH1, NOTCH3
8
Notch signaling pathway (KEGG)
Show member pathways
8.5JAG1, JAG2, NOTCH1, NOTCH3
98.1CDC73, JAG1, JAG2, NOTCH1, NOTCH3

GO Terms for genes affiliated with Ossifying Fibroma

About this section

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junctionGO:00059129.5JAG1, NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:000991210.3JAG2, NOTCH1
2distal tubule developmentGO:007201710.2JAG1, NOTCH1
3Notch signaling involved in heart developmentGO:006131410.1JAG1, NOTCH1
4pulmonary valve morphogenesisGO:000318410.1JAG1, NOTCH1
5embryonic hindlimb morphogenesisGO:003511610.1GNAS, NOTCH1
6negative regulation of stem cell differentiationGO:200073710.1JAG1, NOTCH1
7cell communicationGO:000715410.1JAG1, JAG2
8regulation of developmental processGO:005079310.0NOTCH1, NOTCH3
9response to muramyl dipeptideGO:003249510.0JAG1, NOTCH1
10neuron fate commitmentGO:004866310.0NOTCH1, NOTCH3
11neuronal stem cell population maintenanceGO:009715010.0JAG1, NOTCH1
12positive regulation of osteoblast differentiationGO:004566910.0GNAS, JAG1
13cardiac septum morphogenesisGO:00604119.8JAG1, NOTCH1
14keratinocyte differentiationGO:00302169.7JAG1, NOTCH1
15positive regulation of Notch signaling pathwayGO:00457479.7JAG1, JAG2, NOTCH1
16forebrain developmentGO:00309009.6NOTCH1, NOTCH3
17negative regulation of cell differentiationGO:00455969.3JAG1, NOTCH1, NOTCH3
18negative regulation of neuron differentiationGO:00456659.3JAG1, NOTCH1, NOTCH3
19regulation of cell proliferationGO:00421279.2JAG1, JAG2, NOTCH1
20Notch receptor processingGO:00072209.0JAG1, JAG2, NOTCH1, NOTCH3
21Notch signaling pathwayGO:00072198.9JAG1, JAG2, NOTCH1, NOTCH3
22regulation of cell migrationGO:00303348.8JAG1, JAG2, NOTCH1
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.5CDC73, JAG1, NOTCH1, NOTCH3
24multicellular organismal developmentGO:00072758.4JAG1, JAG2, NOTCH1, NOTCH3

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051129.6JAG1, JAG2, NOTCH1
2calcium ion bindingGO:00055098.5JAG1, JAG2, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet