MCID: OSS001
MIFTS: 45

Ossifying Fibroma

Categories: Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Ossifying Fibroma

MalaCards integrated aliases for Ossifying Fibroma:

Name: Ossifying Fibroma 12 14 69
Peripheral Ossifying Fibroma 12 69
Fibroma, Ossifying 41
Fibroma Ossifying 51
Fibro-Osteoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:180
MeSH 41 D018214
NCIt 46 C8422

Summaries for Ossifying Fibroma

Disease Ontology : 12 A bone benign neoplasm that is located in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary : Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and fibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. Affiliated tissues include the mouth, bone and testes, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 juvenile ossifying fibroma 34.1 MDM2 RASAL1
2 fibrous dysplasia 30.7 CDC73 GNAS
3 osteofibrous dysplasia 12.0
4 hyperparathyroidism 2 with jaw tumors 11.7
5 gigantiform cementoma, familial 11.3
6 encephalocraniocutaneous lipomatosis 11.1
7 sinusitis 10.5
8 aneurysmal bone cysts 10.4
9 aneurysm 10.4
10 pyogenic granuloma 10.2
11 hyperparathyroidism 10.2
12 gingivitis 10.2
13 juxtacortical osteosarcoma 10.1 GNAS MDM2
14 musculoskeletal system benign neoplasm 10.1 CDC73 ERCC6
15 meningioma, familial 10.1
16 periodontitis 10.1
17 peripheral osteosarcoma 10.1 GNAS MDM2
18 neurofibromatosis, type iv, of riccardi 10.0
19 chondrosarcoma 10.0
20 episodic pain syndrome, familial, 1 10.0
21 osteoblastoma 10.0
22 mastoiditis 10.0
23 monostotic fibrous dysplasia 10.0
24 nodular regenerative hyperplasia 9.9 JAG1 NOTCH1
25 cell type benign neoplasm 9.9 CDC73 GNAS
26 adamantinoma of long bones 9.8
27 cowden syndrome 1 9.8
28 buschke-ollendorff syndrome 9.8
29 retinoblastoma 9.8
30 tuberous sclerosis 1 9.8
31 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
32 oculoectodermal syndrome 9.8
33 ameloblastoma 9.8
34 fanconi syndrome 9.8
35 sphenoid sinusitis 9.8
36 primary hyperparathyroidism 9.8
37 orbital cellulitis 9.8
38 chronic apical periodontitis 9.8
39 tuberous sclerosis 9.8
40 giant cell tumor 9.8
41 cellulitis 9.8
42 bilateral retinoblastoma 9.8
43 epulis 9.8
44 juxtacortical chondrosarcoma 9.8
45 adenoma 9.8
46 psammomatous meningioma 9.8
47 parathyroid adenoma 9.8
48 hyperthyroidism 9.8
49 exophthalmos 9.8
50 periostitis 9.8

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to Ossifying Fibroma

Symptoms & Phenotypes for Ossifying Fibroma

MGI Mouse Phenotypes related to Ossifying Fibroma:

43 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 NOTCH1 JAG1 MDM2 JAG2 NOTCH3 ERCC6
2 cellular MP:0005384 10.13 JAG1 MDM2 NOTCH1 NOTCH3 CDC73 GNAS
3 hematopoietic system MP:0005397 10.11 MDM2 JAG2 NOTCH1 NOTCH3 ERCC6 JAG1
4 homeostasis/metabolism MP:0005376 10.1 JAG1 MDM2 JAG2 NOTCH1 NOTCH3 GNAS
5 endocrine/exocrine gland MP:0005379 10.09 JAG1 MDM2 JAG2 NOTCH1 NOTCH3 CDC73
6 cardiovascular system MP:0005385 10.07 JAG1 MDM2 NOTCH1 NOTCH3 CDC73 GNAS
7 integument MP:0010771 10.06 MDM2 JAG2 NOTCH1 NOTCH3 ERCC6 JAG1
8 craniofacial MP:0005382 10.05 MDM2 JAG2 NOTCH1 JAG1 CDC73 GNAS
9 embryo MP:0005380 10.03 NOTCH1 JAG1 MDM2 JAG2 NOTCH3 CDC73
10 immune system MP:0005387 10.02 MDM2 JAG2 NOTCH1 NOTCH3 GNAS ERCC6
11 mortality/aging MP:0010768 10.01 JAG1 MDM2 JAG2 NOTCH1 NOTCH3 GNAS
12 hearing/vestibular/ear MP:0005377 10 JAG2 NOTCH1 NOTCH3 ERCC6 JAG1 GNAS
13 digestive/alimentary MP:0005381 9.97 JAG2 JAG1 MDM2 NOTCH1 CDC73
14 liver/biliary system MP:0005370 9.91 JAG1 MDM2 NOTCH1 ERCC6 CDC73 GNAS
15 muscle MP:0005369 9.91 MDM2 NOTCH1 NOTCH3 ERCC6 JAG1 CDC73
16 nervous system MP:0003631 9.86 JAG1 MDM2 JAG2 NOTCH1 NOTCH3 ERCC6
17 neoplasm MP:0002006 9.8 MDM2 NOTCH1 NOTCH3 ERCC6 CDC73 GNAS
18 renal/urinary system MP:0005367 9.63 NOTCH1 JAG1 MDM2 NOTCH3 CDC73 GNAS
19 respiratory system MP:0005388 9.35 JAG2 NOTCH1 NOTCH3 CDC73 GNAS
20 skeleton MP:0005390 9.23 MDM2 JAG2 NOTCH1 NOTCH3 ERCC6 JAG1

Drugs & Therapeutics for Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Ossifying Fibroma

Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

Anatomical Context for Ossifying Fibroma

The Foundational Model of Anatomy Ontology organs/tissues related to Ossifying Fibroma:

18
The Mouth

MalaCards organs/tissues related to Ossifying Fibroma:

38
Bone, Testes, Bone Marrow

Publications for Ossifying Fibroma

Articles related to Ossifying Fibroma:

(show top 50) (show all 620)
# Title Authors Year
1
Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma. ( 28991228 )
2018
2
MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma. ( 29032608 )
2018
3
Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla. ( 29152441 )
2017
4
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity. ( 28932332 )
2017
5
Pediatric cemento-ossifying fibroma of the orbital roof: Rare pathology at a rare location. ( 28681781 )
2017
6
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. ( 28566876 )
2017
7
Clinicopathological Characteristics and Prognosis of Ossifying Fibroma in the Jaws of Children: A Retrospective Study. ( 29151945 )
2017
8
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. ( 28642188 )
2017
9
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report. ( 28402358 )
2017
10
Conservative Management of Central Cemento-Ossifying Fibroma. ( 27831973 )
2017
11
Aggressive ossifying fibroma of right ethmoidal sinus: A case report. ( 29373206 )
2017
12
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. ( 28467645 )
2017
13
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
14
940 nm Diode Laser assisted excision of Peripheral Ossifying Fibroma in a neonate. ( 28740329 )
2017
15
Cemento-ossifying fibroma of the mandible. A clinicopathological report. ( 28439606 )
2017
16
Juvenile psammomatoid ossifying fibroma in paranasal sinus and skull base. ( 28125310 )
2017
17
The aetiology of the non-ossifying fibroma of the distal femur and its relationship to the surrounding soft tissues. ( 29081852 )
2017
18
A large psammomatoid ossifying fibroma with proptosis: A case report. ( 28357086 )
2017
19
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
20
Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study. ( 28195085 )
2017
21
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. ( 28588818 )
2017
22
Ossifying fibroma: an uncommon differential diagnosis for T2-hypointense sinonasal masses. ( 28491178 )
2017
23
The role of Osterix protein in the pathogenesis of peripheral ossifying fibroma. ( 28678972 )
2017
24
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
25
Ossifying fibroma of the maxilla and sinonasal tract: Case series. ( 28381325 )
2017
26
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. ( 28292370 )
2017
27
Juvenile Trabecular Ossifying Fibroma. ( 29027609 )
2017
28
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. ( 27922957 )
2017
29
Osteofibrous Dysplasia Versus Ossifying Fibroma: Semantic Confusion. ( 28238823 )
2017
30
Orbital ossifying fibroma: A case report. ( 26928888 )
2016
31
Cemento-ossifying fibroma of mandible mimicking complex composite odontome. ( 27797795 )
2016
32
Cranial juvenile psammomatoid ossifying fibroma: case report. ( 26588460 )
2016
33
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). ( 27476108 )
2016
34
Juvenile Trabecular Ossifying Fibroma of the Maxilla: a Case Report. ( 28210024 )
2016
35
Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery? ( 27192645 )
2016
36
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. ( 27513775 )
2016
37
Endonasal endoscopic resection of ossifying fibroma involving the ethmoid sinus, orbit and anterior skull base: case report and literature review. ( 27196080 )
2016
38
Commentary on: "An update on peripheral ossifying fibroma: case report and literature review". ( 27891559 )
2016
39
Unusually large-sized peripheral ossifying fibroma. ( 28299276 )
2016
40
Peripheral ossifying fibroma: A rare case affecting maxillary region. ( 27795650 )
2016
41
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. ( 27044378 )
2016
42
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. ( 27192894 )
2016
43
Nonvascularized Free Transport Distraction Osteogenesis to Reconstruct the Mandibular Defect of a Patient With an Ossifying Fibroma: AA Case Report. ( 27292526 )
2016
44
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. ( 27658992 )
2016
45
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. ( 27311848 )
2016
46
Erratum: Cemento-ossifying fibroma of the jaw. ( 27261511 )
2016
47
Cemento-ossifying fibroma of the jaw. ( 27174452 )
2016
48
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". ( 27888362 )
2016
49
Case of the Month: Peripheral Ossifying Fibroma. ( 27476233 )
2016
50
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. ( 26962494 )
2016

Variations for Ossifying Fibroma

Expression for Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for Ossifying Fibroma

Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CDC73 GNAS JAG1 JAG2 MDM2 NOTCH1
2
Show member pathways
13.42 JAG1 JAG2 MDM2 NOTCH1 NOTCH3 RASAL1
3
Show member pathways
12.63 GNAS JAG1 MDM2 NOTCH1 NOTCH3
4
Show member pathways
12.61 JAG1 JAG2 NOTCH1 NOTCH3
5
Show member pathways
12.48 JAG1 JAG2 NOTCH1 NOTCH3
6 12.46 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
7
Show member pathways
12.32 JAG1 JAG2 NOTCH1 NOTCH3
8
Show member pathways
12.3 JAG1 JAG2 NOTCH1 NOTCH3
9 12.24 MDM2 NOTCH1 NOTCH3
10
Show member pathways
11.96 JAG1 JAG2 NOTCH1
11
Show member pathways
11.95 GNAS JAG1 JAG2 MDM2 NOTCH1 NOTCH3
12
Show member pathways
11.85 JAG1 JAG2 NOTCH1
13 11.81 CDC73 JAG1 JAG2 NOTCH1 NOTCH3
14 11.74 MDM2 NOTCH1 NOTCH3
15 11.55 JAG1 NOTCH1 NOTCH3
16 11.21 JAG1 JAG2 NOTCH1
17 10.77 JAG1 NOTCH1
18 10.75 JAG1 JAG2 NOTCH1
19 10.36 JAG1 JAG2 NOTCH1 NOTCH3

GO Terms for Ossifying Fibroma

Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 GNAS JAG1 NOTCH1

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.93 JAG2 NOTCH1 NOTCH3 RASAL1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 CDC73 MDM2 NOTCH1 NOTCH3
3 regulation of cell proliferation GO:0042127 9.77 JAG1 JAG2 NOTCH1
4 regulation of cell migration GO:0030334 9.65 JAG1 JAG2 NOTCH1
5 negative regulation of cell differentiation GO:0045596 9.63 JAG1 NOTCH1 NOTCH3
6 positive regulation of osteoblast differentiation GO:0045669 9.62 GNAS JAG1
7 cell communication GO:0007154 9.62 JAG1 JAG2
8 protein destabilization GO:0031648 9.61 CDC73 MDM2
9 negative regulation of neuron differentiation GO:0045665 9.61 JAG1 NOTCH1 NOTCH3
10 blood vessel remodeling GO:0001974 9.59 JAG1 MDM2
11 neuron fate commitment GO:0048663 9.58 NOTCH1 NOTCH3
12 embryonic hindlimb morphogenesis GO:0035116 9.58 GNAS NOTCH1
13 neuronal stem cell population maintenance GO:0097150 9.57 JAG1 NOTCH1
14 endocardial cushion morphogenesis GO:0003203 9.56 MDM2 NOTCH1
15 negative regulation of stem cell differentiation GO:2000737 9.55 JAG1 NOTCH1
16 response to muramyl dipeptide GO:0032495 9.54 JAG1 NOTCH1
17 atrioventricular valve morphogenesis GO:0003181 9.52 MDM2 NOTCH1
18 pulmonary valve morphogenesis GO:0003184 9.51 JAG1 NOTCH1
19 Notch signaling involved in heart development GO:0061314 9.49 JAG1 NOTCH1
20 Notch signaling pathway GO:0007219 9.46 JAG1 JAG2 NOTCH1 NOTCH3
21 positive regulation of Notch signaling pathway GO:0045747 9.43 JAG1 JAG2 NOTCH1
22 regulation of developmental process GO:0050793 9.4 NOTCH1 NOTCH3
23 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
24 auditory receptor cell fate commitment GO:0009912 9.32 JAG2 NOTCH1
25 Notch receptor processing GO:0007220 9.13 JAG1 JAG2 NOTCH3
26 cardiac septum morphogenesis GO:0060411 8.8 JAG1 MDM2 NOTCH1

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 JAG1 JAG2 NOTCH1 NOTCH3
2 Notch binding GO:0005112 8.8 JAG1 JAG2 NOTCH1

Sources for Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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