MCID: OSS001
MIFTS: 55

Ossifying Fibroma malady

Cancer diseases, Bone diseases, Oral diseases categories

Summaries for Ossifying Fibroma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards: Ossifying Fibroma, also known as fibroma ossifying, is related to fibroma and fibrous dysplasia. An important gene associated with Ossifying Fibroma is JAG2 (jagged 2), and among its related pathways are Notch signaling pathway and Dorso-ventral axis formation. The compounds alizarin and titanium have been mentioned in the context of this disorder. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Wikipedia:66 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

Aliases & Classifications for Ossifying Fibroma

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9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Oral diseases


Aliases & Descriptions:

ossifying fibroma 9 11 63
fibroma ossifying 46
fibro-osteoma 9


External Ids:

Disease Ontology9 DOID:180
MeSH36 D018214
NCIt41 C8422

Related Diseases for Ossifying Fibroma

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18GeneCards, 19GeneDecks
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Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma32.4CDC73
2fibrous dysplasia31.1GNAS, BGLAP, RUNX2
3osteofibrous dysplasia31.1GNAS, BGLAP
4hyperparathyroidism30.7CDC73, BGLAP
5osteosarcoma30.6RUNX2, BGLAP, NOTCH1
6meningioma30.6GFAP, MUC1
7psammomatous meningioma30.4ERCC6
8parathyroid adenoma30.4GNAS, CDC73
9primary hyperparathyroidism30.3BGLAP, CDC73
10giant cell tumor30.3BGLAP, MUC1
11sinusitis10.7
12aneurysmal bone cysts10.6
13aneurysm10.6
14pyogenic granuloma10.5
15neurofibromatosis10.3
16chondrosarcoma10.3
17periodontitis10.3
18monostotic fibrous dysplasia10.3
19osteoblastoma10.2
20fanconi syndrome10.2
21exophthalmos10.2
22bilateral retinoblastoma10.2
23chronic apical periodontitis10.2
24orbital cellulitis10.2
25juxtacortical chondrosarcoma10.2
26adenoma10.2
27cellulitis10.2
28epulis10.2
29gingivitis10.2
30hyperthyroidism10.2
31periostitis10.2
32retinoblastoma10.2
33sphenoid sinusitis10.2
34fibromatosis10.2
35florid cemento-osseous dysplasia10.2
36lipoblastoma10.2
37chondroblastic osteosarcoma10.1BGLAP
38saethre-chotzen syndrome10.1BGLAP
39left ventricular outflow tract obstruction10.1NOTCH1
40multiple endocrine neoplasia10.1GNAS, CDC73
41wermer syndrome10.1GNAS, CDC73
42pseudohypoparathyroidism type 1b10.1BGLAP, GNAS
43alagille syndrome10.1NOTCH1, JAG1
44osteitis fibrosa10.1BGLAP, GNAS
45pseudohypoparathyroidism10.1GNAS, BGLAP
46choroid plexus papilloma10.1GFAP
47osteomalacia10.1BGLAP, GNAS
48hyperphosphatemia10.1RUNX2, GNAS
49goiter10.1BGLAP, GNAS
50cleidocranial dysplasia10.1RUNX2, BGLAP

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ossifying Fibroma

Drug clinical trials:

Search ClinicalTrials for Ossifying Fibroma

Search NIH Clinical Center for Ossifying Fibroma

Search CenterWatch for Ossifying Fibroma

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Ossifying Fibroma:

34
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

15
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ossifying Fibroma:

38 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2GNAS, JAG1, JAG2, NOTCH3, NOTCH1
2MP:00053679.0CDC73, NOTCH1, NOTCH3, JAG1, GNAS
3MP:00053829.0RUNX2, GNAS, JAG1, JAG2, NOTCH1
4MP:00053808.9JAG1, JAG2, NOTCH3, NOTCH1, CDC73
5MP:00053888.8RUNX2, GNAS, JAG2, NOTCH3, NOTCH1, CDC73
6MP:00053718.7RUNX2, GNAS, JAG2, ERCC6
7MP:00053898.7CDC73, NOTCH3, HMMR, JAG2, RUNX2
8MP:00030128.7RUNX2, GNAS, MUC1, JAG1, JAG2
9MP:00053908.4RUNX2, GNAS, JAG1, JAG2, ERCC6, NOTCH3
10MP:00020068.4MUC1, ERCC6, HMMR, NOTCH3, NOTCH1
11MP:00053868.3GFAP, GNAS, JAG1, ERCC6, NOTCH3, CDC73
12MP:00053858.3RUNX2, GFAP, GNAS, JAG1, NOTCH3, NOTCH1
13MP:00053798.2RUNX2, GNAS, MUC1, JAG1, NOTCH3, NOTCH1
14MP:00028738.2GFAP, GNAS, MUC1, JAG1, NOTCH3, NOTCH1
15MP:00053978.1RUNX2, GNAS, JAG1, JAG2, ERCC6, NOTCH3
16MP:00053708.1RUNX2, GNAS, MUC1, JAG1, ERCC6, NOTCH1
17MP:00053818.1RUNX2, GFAP, MUC1, JAG1, JAG2, NOTCH1
18MP:00053918.0RUNX2, GFAP, MUC1, JAG1, ERCC6, NOTCH1
19MP:00053697.9RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
20MP:00053877.9RUNX2, GFAP, GNAS, JAG2, ERCC6, NOTCH3
21MP:00053847.8RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
22MP:00053787.8RUNX2, GFAP, GNAS, JAG1, ERCC6, NOTCH3
23MP:00036317.6RUNX2, GFAP, GNAS, JAG1, JAG2, ERCC6
24MP:00107687.6RUNX2, GFAP, GNAS, JAG1, JAG2, ERCC6
25MP:00107717.6CDC73, RUNX2, GNAS, MUC1, JAG1, JAG2
26MP:00053767.0RUNX2, GFAP, GNAS, MUC1, JAG1, JAG2

Publications for Ossifying Fibroma

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Sources:
53PubMed
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Articles related to Ossifying Fibroma:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
2
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
3
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
4
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
5
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
6
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
7
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
8
Placement of implants in an ossifying fibroma defect obliterated with demineralized, freeze-dried bone allograft and Plasma-rich growth factor. (23633812)
2012
9
Trabecular and psammomatoid juvenile ossifying fibroma of the skull base mimicking psammomatoid meningioma. (20953744)
2011
10
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
11
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
12
Peripheral cemento-ossifying fibroma--a case report. (21356015)
2011
13
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
14
A case report of cemento-ossifying fibroma. (22190782)
2010
15
Juvenile central ossifying fibroma of the mandible: a case report. (20920702)
2010
16
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
17
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
18
Giant ossifying fibroma complicated by mucocele of sphenoid sinus--case report. (19105117)
2008
19
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
20
Case of the month: peripheral ossifying fibroma. (18546612)
2008
21
Large cemento-ossifying fibroma of the maxilla causing proptosis: a case report. (17706436)
2007
22
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
23
Ossifying fibroma of long bones in adults: a case report. (17260623)
2006
24
Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). (16407489)
2006
25
Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. (16632273)
2006
26
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
27
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
28
Ossifying fibroma of the jaw. (15372914)
2004
29
Psammomatoid ossifying fibroma of the ethmoid. (12784573)
2003
30
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
31
Aggressive psammomatoid ossifying fibroma of the inferior turbinate and lateral nasal wall. (12642959)
2003
32
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
33
Peripheral ossifying fibroma of the maxillary gingiva. (11806482)
2001
34
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space. (10543652)
1999
35
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
36
Ossifying fibroma/osteoma in the proximal tibia of a mature gelding. (9800307)
1998
37
Maxillary sinus ossifying fibroma. (9395021)
1997
38
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
39
Ossifying fibroma of the skull: clinical and therapeutic study. (8191602)
1994
40
Central ossifying fibroma. (8060568)
1993
41
Giant ossifying fibroma. Case report on a bimaxillary presentation. (1402053)
1992
42
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
43
Ossifying fibroma of the jaws: a case report. (1765021)
1991
44
Case presentation: ossifying fibroma. (1820513)
1991
45
Ossifying fibroma in the sylvian fissure: case report. (1870672)
1991
46
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
47
Giant ossifying fibroma of the nasal cavity with intracranial extension. (7246283)
1981
48
Ossifying fibroma in a greater kudu. (411210)
1977
49
Ossifying Fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws. (821512)
1976
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ossifying Fibroma

Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Sources:
51PathCards, 31KEGG, 58SinoBiological, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 5Cell Signaling Technology, 54QIAGEN, 55R&D Systems
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Pathways related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8JAG1, NOTCH1
29.8NOTCH1, NOTCH3
3
Show member pathways
9.8NOTCH1, NOTCH3
49.7BGLAP, RUNX2
59.7BGLAP, RUNX2
6
Show member pathways
Development Notch Signaling Pathway61
Transcription Sin3 and NuRD in transcription regulation61
9.6JAG1, JAG2, NOTCH1
7
Show member pathways
9.6NOTCH1, JAG2, JAG1
89.5JAG1, NOTCH3, NOTCH1
99.4RUNX2, BGLAP, GNAS
109.3NOTCH1, BGLAP, RUNX2
119.3NOTCH1, NOTCH3, GFAP
129.3NOTCH1, NOTCH3, GFAP
13
Show member pathways
Notch signaling pathway39
9.3NOTCH1, NOTCH3, JAG2, JAG1
14
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.3JAG1, JAG2, NOTCH3, NOTCH1
15
Show member pathways
9.3NOTCH1, NOTCH3, JAG2, JAG1
169.0JAG1, JAG2, NOTCH3, NOTCH1, CDC73
178.9NOTCH1, NOTCH3, JAG2, JAG1, RUNX2
18
Show member pathways
8.4GFAP, GNAS, JAG1, JAG2, NOTCH3, NOTCH1
198.2ODAM, JAG1, JAG2, HMMR, NOTCH1

Compounds for genes affiliated with Ossifying Fibroma

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1alizarin4610.1BGLAP, RUNX2
2titanium469.9RUNX2, BGLAP
3alendronate46 52 1211.8RUNX2, BGLAP
4eosin469.7MUC1, GFAP
5s 100469.7MUC1, GFAP
6reticulin469.6GFAP, MUC1
7ribonucleic acid469.3MUC1, GNAS, RUNX2
8acth469.2MUC1, GNAS, GFAP
9pge2469.2HMMR, GNAS, BGLAP, RUNX2
10matrigel469.1NOTCH1, MUC1, GFAP
11arginine469.1NOTCH3, GNAS, GFAP, BGLAP
12butyrate468.9RUNX2, GFAP, MUC1
13thymidine46 259.9MUC1, GNAS, GFAP, RUNX2
14alanine468.9GNAS, GFAP, BGLAP, RUNX2
15cyclic amp46 259.9MUC1, GNAS, GFAP, RUNX2
16nitric oxide46 25 1210.8RUNX2, GNAS, MUC1, JAG1, NOTCH1
17cysteine468.7BGLAP, GFAP, GNAS, MUC1, NOTCH3
18dexamethasone46 52 30 1211.6NOTCH1, MUC1, GFAP, BGLAP, RUNX2
19vegf468.6RUNX2, BGLAP, GFAP, MUC1, NOTCH1
20oxygen46 259.6RUNX2, GFAP, GNAS, MUC1, NOTCH1
21threonine468.5NOTCH1, MUC1, GNAS, GFAP
22estrogen468.5RUNX2, BGLAP, GFAP, MUC1, NOTCH1
23retinoic acid46 259.5RUNX2, BGLAP, GFAP, MUC1, NOTCH1
24glutamate468.5GFAP, GNAS, ERCC6, NOTCH1
25lipid468.5RUNX2, GFAP, GNAS, MUC1, NOTCH1
26serine468.2RUNX2, BGLAP, GFAP, GNAS, MUC1, NOTCH1
27tyrosine468.0RUNX2, GFAP, GNAS, MUC1, HMMR, NOTCH1
28calcium46 52 25 1211.0RUNX2, BGLAP, GFAP, GNAS, MUC1, NOTCH3

GO Terms for genes affiliated with Ossifying Fibroma

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17Gene Ontology
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Cellular components related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7NOTCH1, NOTCH3, JAG1, ODAM, GNAS, BGLAP
2cytoplasmGO:0057377.0GFAP, GNAS, ODAM, MUC1, HMMR, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:00991210.2JAG2, NOTCH1
2distal tubule developmentGO:07201710.1NOTCH1, JAG1
3negative regulation of stem cell differentiationGO:200073710.1JAG1, NOTCH1
4cardiac septum morphogenesisGO:06041110.1JAG1, NOTCH1
5pulmonary valve morphogenesisGO:00318410.1NOTCH1, JAG1
6Notch signaling involved in heart developmentGO:06131410.1JAG1, NOTCH1
7response to muramyl dipeptideGO:03249510.1NOTCH1, JAG1
8neuronal stem cell maintenanceGO:09715010.1JAG1, NOTCH1
9T cell differentiationGO:03021710.0RUNX2, JAG2
10osteoblast developmentGO:00207610.0BGLAP, RUNX2
11embryonic cranial skeleton morphogenesisGO:0487019.9RUNX2, GNAS
12embryonic hindlimb morphogenesisGO:0351169.9NOTCH1, GNAS
13endochondral ossificationGO:0019589.9GNAS, RUNX2
14negative regulation of neuron differentiationGO:0456659.9JAG1, NOTCH3
15bone developmentGO:0603489.9GNAS, BGLAP
16keratinocyte differentiationGO:0302169.8NOTCH1, JAG1
17forebrain developmentGO:0309009.7NOTCH1, NOTCH3
18regulation of cell migrationGO:0303349.6JAG1, JAG2
19Notch receptor processingGO:0072209.6NOTCH3, JAG1, JAG2, NOTCH1
20transcription initiation from RNA polymerase II promoterGO:0063679.6NOTCH3, RUNX2, NOTCH1
21Notch signaling pathwayGO:0072199.6JAG1, JAG2, NOTCH3, NOTCH1
22odontogenesis of dentin-containing toothGO:0424759.3JAG2, ODAM, RUNX2

Molecular functions related to Ossifying Fibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.6JAG1, JAG2
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.4RUNX2, MUC1
3calcium ion bindingGO:0055098.9NOTCH3, BGLAP, JAG1, NOTCH1, JAG2
4protein bindingGO:0055157.1JAG2, RUNX2, JAG1, MUC1, GNAS, ERCC6

Products for genes affiliated with Ossifying Fibroma

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  • Antibodies
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Sources for Ossifying Fibroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet