MCID: OSS001
MIFTS: 42

Ossifying Fibroma malady

Categories: Cancer diseases, Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

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Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 11 13 68
Peripheral Ossifying Fibroma 11 68
Fibroma, Ossifying 39
 
Fibroma Ossifying 50
Fibro-Osteoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:180
MeSH39 D018214
NCIt45 C8422

Summaries for Ossifying Fibroma

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Disease Ontology:11 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and osteofibrous dysplasia. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and Development NOTCH1-mediated pathway for NF-KB activity modulation. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are respiratory system and craniofacial.

Related Diseases for Ossifying Fibroma

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Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile ossifying fibroma12.3
2osteofibrous dysplasia11.9
3hyperparathyroidism-jaw tumor syndrome11.4
4gigantiform cementoma, familial11.2
5fibroma11.1
6sinusitis10.4
7fibrous dysplasia10.3
8aneurysmal bone cysts10.2
9aneurysm10.2
10polyarticular onset juvenile idiopathic arthritis10.2MDM2, RASAL1
11bone osteosarcoma10.2GNAS, MDM2
12pyogenic granuloma10.1
13small cell osteogenic sarcoma10.1GNAS, MDM2
14hyperparathyroidism10.1
15gingivitis10.1
16periodontitis10.0
17mirage syndrome9.9JAG1, NOTCH1
18chondrosarcoma9.9
19mastoiditis9.9
20monostotic fibrous dysplasia9.9
21male reproductive organ benign neoplasm9.9CDC73, GNAS
22testicular trophoblastic tumor9.8JAG1, NOTCH1
23buschke-ollendorff syndrome9.8
24retinoblastoma9.8
25neurofibromatosis, type 19.8
26oculoectodermal syndrome9.8
27adamantinoma of long bones9.8
28osteoblastoma9.8
29sphenoid sinusitis9.8
30orbital cellulitis9.8
31chronic apical periodontitis9.8
32giant cell tumor9.8
33cellulitis9.8
34bilateral retinoblastoma9.8
35epulis9.8
36juxtacortical chondrosarcoma9.8
37adenoma9.8
38psammomatous meningioma9.8
39parathyroid adenoma9.8
40hyperthyroidism9.8
41exophthalmos9.8
42periostitis9.8
43fibromatosis9.8
44florid cemento-osseous dysplasia9.8
45lipoblastoma9.8
46keratocystic odontogenic tumor9.8
47trench fever9.7NOTCH1, NOTCH3
48papillary ependymoma9.7JAG1, NOTCH1
49dyserythropoietic anemia, congenital, type ii9.7JAG1, NOTCH1
50chondromalacia9.6JAG1, NOTCH1

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms & Phenotypes for Ossifying Fibroma

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MGI Mouse Phenotypes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CDC73, GNAS, JAG2, NOTCH1, NOTCH3
2MP:00053828.4GNAS, JAG1, JAG2, MDM2, NOTCH1
3MP:00020068.2ERCC6, GNAS, MDM2, NOTCH1, NOTCH3
4MP:00053708.0CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
5MP:00053817.8CDC73, JAG1, JAG2, MDM2, NOTCH1
6MP:00053777.8ERCC6, GNAS, JAG1, JAG2, NOTCH1, NOTCH3
7MP:00053807.7CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
8MP:00053677.4CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053797.3CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
10MP:00053877.3CDC73, ERCC6, GNAS, JAG2, MDM2, NOTCH1
11MP:00053857.3CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
12MP:00053697.3CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
13MP:00053847.2CDC73, ERCC6, GNAS, JAG1, MDM2, NOTCH1
14MP:00053907.1ERCC6, GNAS, JAG1, JAG2, MDM2, NOTCH1
15MP:00107716.7CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
16MP:00053976.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
17MP:00107686.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
18MP:00053786.6CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
19MP:00036316.5CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2
20MP:00053766.5CDC73, ERCC6, GNAS, JAG1, JAG2, MDM2

Drugs & Therapeutics for Ossifying Fibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

36
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

17
The mouth

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. (27922957)
2017
2
Conservative Management of Central Cemento-Ossifying Fibroma. (27831973)
2017
3
Ossifying Fibroma: Analysis of Treatment Methods and Recurrence Patterns. (27311848)
2016
4
Cutaneous Ossifying Fibroma in a Neon Tetra (Paracheirodon innesi). (27476108)
2016
5
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. (27513775)
2016
6
Reply to the "Letter to the Editor" commenting on the article "An Update of Peripheral Ossifying Fibroma: Case Report and Literature Review". (27888362)
2016
7
Commentary on: "An update on peripheral ossifying fibroma: case report and literature review". (27891559)
2016
8
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. (27134454)
2016
9
Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery? (27192645)
2016
10
Juvenile psammomatoid ossifying fibroma of the posterior fossa: a case report and review. (27468389)
2016
11
Peripheral ossifying fibroma: A rare case affecting maxillary region. (27795650)
2016
12
Nonvascularized Free Transport Distraction Osteogenesis to Reconstruct the Mandibular Defect of a Patient With an Ossifying Fibroma: AA Case Report. (27292526)
2016
13
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. (26740351)
2016
14
Endonasal endoscopic resection of ossifying fibroma involving the ethmoid sinus, orbit and anterior skull base: case report and literature review. (27196080)
2016
15
CDC73 gene mutations in sporadic ossifying fibroma of the jaws. (27658992)
2016
16
Cranial juvenile psammomatoid ossifying fibroma: case report. (26588460)
2016
17
Case of the Month: Peripheral Ossifying Fibroma. (27476233)
2016
18
Oral Pathology. Common Oral Gingival Lesions. Diagnosis: Peripheral ossifying fibroma. (27263144)
2016
19
Juvenile Psammomatoid Ossifying Fibroma: Findings on Bone Scan. (27405032)
2016
20
Coverage Root after Removing Peripheral Ossifying Fibroma: 5-Year Follow-Up Case Report. (27891263)
2016
21
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. (27044378)
2016
22
Ossifying fibroma: report on a clinical case, with the imaging and histopathological diagnosis made and treatment administered. (26962494)
2016
23
OCULOECTODERMAL SYNDROME: A NEW CASE WITH GIANT CELL GRANULOMAS AND NON-OSSIFYING FIBROMAS. (27192894)
2016
24
Erratum: Cemento-ossifying fibroma of the jaw. (27261511)
2016
25
Cemento-ossifying fibroma of the jaw. (27174452)
2016
26
Orbital ossifying fibroma: A case report. (26928888)
2016
27
Cemento-ossifying fibroma of mandible mimicking complex composite odontome. (27797795)
2016
28
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
29
Oxytalan-positive peripheral ossifying fibromas express runt-related transcription factor 2, bone morphogenetic protein-2, and cementum attachment protein. An immunohistochemical study. (25359431)
2015
30
Percutaneous cryoablation for a symptomatic non-ossifying fibroma. A case report. (25533495)
2015
31
Is Computed Tomography an Adequate Imaging Modality for the Evaluation of Juvenile Ossifying Fibroma? A Comparison of 2 Imaging Modalities (Computed Tomography and Magnetic Resonance Imaging). (25911216)
2015
32
Giant central ossifying fibroma of the maxilla presenting with a pus discharging intra-oral sinus. (25738089)
2015
33
Management of residual mucogingival defect resulting from the excision of recurrent peripheral ossifying fibroma by periodontal plastic surgical procedure. (26604587)
2015
34
Application of 810-nm diode laser in the management of peripheral ossifying fibroma. (26015678)
2015
35
Ipsilateral maxillo-mandibular ossifying fibroma. (25838685)
2015
36
Maxillo-Mandibular Cemento-ossifying Fibroma: A Rare Case Report. (25838714)
2015
37
Huge ossifying fibroma maxilla. (27390506)
2015
38
Cemento-ossifying fibroma of mandible: An unusual case report and review of literature. (26980975)
2015
39
Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina. (26811709)
2015
40
Psammomatoid Juvenile Ossifying Fibroma Involving Upper Jaw: A Rare Case Report. (26393222)
2015
41
Intranasal endoscopic prelacrimal recess approach to sinonasal juvenile ossifying fibroma. (25635449)
2015
42
Oral pathology quiz #88. Case Number 4. Peripheral ossifying fibroma. (26495674)
2015
43
Reduction surgery using a combination of a stereolithographic model and navigation system for ossifying fibroma with secondary central giant cell granuloma. (26316138)
2015
44
Peripheral ossifying fibroma: A clinicopathologic study of 27 cases and review of the literature with emphasis on histomorphologic features. (25810599)
2015
45
Central Ossifying Fibroma. (26727817)
2015
46
Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: a diagnostic challenge. (24591292)
2015
47
Recurrent peripheral cemento-ossifying fibroma. (26229278)
2015
48
Central Cemento-Ossifying Fibroma: Primary Odontogenic or Osseous Neoplasm? (26608158)
2015
49
Trabecular Variant of Juvenile Aggressive Ossifying Fibroma. (26266018)
2015
50
Management of Ossifying Fibroma in a Suspicious Case of Hyperparathyroid-Jaw Tumor Syndrome. (26269732)
2015

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.1NOTCH1, NOTCH3
2
Show member pathways
8.9JAG1, JAG2, NOTCH1
3
Show member pathways
8.9JAG1, JAG2, NOTCH1
48.9JAG1, JAG2, NOTCH1
58.7MDM2, NOTCH1, NOTCH3
68.7MDM2, NOTCH1, NOTCH3
7
Show member pathways
8.5JAG1, NOTCH1, NOTCH3
8
Show member pathways
8.5JAG1, JAG2, MDM2, NOTCH1
9
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
10
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
117.8CDC73, JAG1, JAG2, NOTCH1, NOTCH3
12
Show member pathways
6.6CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

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Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junctionGO:000591210.1JAG1, NOTCH1
2plasma membraneGO:00058866.9GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1embryonic hindlimb morphogenesisGO:003511610.3GNAS, NOTCH1
2protein destabilizationGO:003164810.3CDC73, MDM2
3auditory receptor cell fate commitmentGO:000991210.3JAG2, NOTCH1
4atrioventricular valve morphogenesisGO:000318110.2MDM2, NOTCH1
5endocardial cushion morphogenesisGO:000320310.2MDM2, NOTCH1
6positive regulation of osteoblast differentiationGO:004566910.1GNAS, JAG1
7blood vessel remodelingGO:000197410.1JAG1, MDM2
8distal tubule developmentGO:007201710.1JAG1, NOTCH1
9negative regulation of stem cell differentiationGO:200073710.1JAG1, NOTCH1
10neuronal stem cell population maintenanceGO:009715010.0JAG1, NOTCH1
11Notch signaling involved in heart developmentGO:006131410.0JAG1, NOTCH1
12pulmonary valve morphogenesisGO:000318410.0JAG1, NOTCH1
13neuron fate commitmentGO:00486639.8NOTCH1, NOTCH3
14cardiac septum morphogenesisGO:00604119.6JAG1, MDM2, NOTCH1
15positive regulation of Notch signaling pathwayGO:00457479.6JAG1, JAG2, NOTCH1
16regulation of cell migrationGO:00303349.5JAG1, JAG2, NOTCH1
17response to muramyl dipeptideGO:00324959.3JAG1, NOTCH1
18Notch receptor processingGO:00072209.3JAG1, JAG2, NOTCH3
19negative regulation of cell differentiationGO:00455969.2JAG1, NOTCH1, NOTCH3
20negative regulation of neuron differentiationGO:00456659.2JAG1, NOTCH1, NOTCH3
21regulation of cell proliferationGO:00421279.2JAG1, JAG2, NOTCH1
22negative regulation of transcription from RNA polymerase II promoterGO:00001229.0CDC73, MDM2, NOTCH1, NOTCH3
23Notch signaling pathwayGO:00072198.7JAG1, JAG2, NOTCH1, NOTCH3

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051128.9JAG1, JAG2, NOTCH1
2calcium ion bindingGO:00055098.4JAG1, JAG2, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet