MCID: OSS001
MIFTS: 48

Ossifying Fibroma malady

Categories: Genetic diseases, Cancer diseases, Bone diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ossifying Fibroma

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Aliases & Descriptions for Ossifying Fibroma:

Name: Ossifying Fibroma 10 12 65
Peripheral Ossifying Fibroma 10 65
Fibroma, Ossifying 36
 
Fibroma Ossifying 47
Fibro-Osteoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:180
MeSH36 D018214
NCIt42 C8422
UMLS65 C0206640, C1290783

Summaries for Ossifying Fibroma

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Disease Ontology:10 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as peripheral ossifying fibroma, is related to juvenile ossifying fibroma and familial ossifying fibroma. An important gene associated with Ossifying Fibroma is CDC73 (Cell Division Cycle 73), and among its related pathways are Dorso-ventral axis formation and MicroRNAs in cancer. Affiliated tissues include the mouth, bone and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Related Diseases for Ossifying Fibroma

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Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma Familial Ossifying Fibroma

Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile ossifying fibroma12.5
2familial ossifying fibroma12.2
3osteofibrous dysplasia11.9
4fibroma11.3
5hyperparathyroidism-jaw tumor syndrome10.7
6sinusitis10.5
7fibrous dysplasia10.5
8aneurysmal bone cysts10.4
9aneurysm10.4
10pyogenic granuloma10.2
11large cell neuroendocrine carcinoma10.2CDC73, GNAS
12peripheral osteosarcoma10.2GNAS, MDM2
13hyperparathyroidism10.2
14juvenile polymyositis10.1MDM2, RASAL1
15craniodiaphyseal dysplasia10.1CDC73, GNAS
16immunodeficiency, common variable, 510.1CDC73, GNAS
17gingivitis10.1
18periodontitis10.1
19bone osteosarcoma10.1GNAS, MDM2
20chondrosarcoma10.0
21mastoiditis10.0
22neurofibromatosis10.0
23monostotic fibrous dysplasia10.0
24uterine benign neoplasm10.0CDC73, GNAS, RASAL1
25middle ear adenoma10.0NOTCH1, NOTCH3
26q fever10.0NOTCH1, NOTCH3
27buschke-ollendorff syndrome9.9
28retinoblastoma9.9
29neurofibromatosis, type 19.9
30osteoblastoma9.9
31fanconi syndrome9.9
32sphenoid sinusitis9.9
33primary hyperparathyroidism9.9
34orbital cellulitis9.9
35chronic apical periodontitis9.9
36tuberous sclerosis9.9
37giant cell tumor9.9
38cellulitis9.9
39bilateral retinoblastoma9.9
40epulis9.9
41juxtacortical chondrosarcoma9.9
42adenoma9.9
43psammomatous meningioma9.9
44parathyroid adenoma9.9
45hyperthyroidism9.9
46exophthalmos9.9
47periostitis9.9
48fibromatosis9.9
49florid cemento-osseous dysplasia9.9
50lipoblastoma9.9

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ossifying Fibroma


Cochrane evidence based reviews: fibroma, ossifying

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

33
Bone, Brain, Breast, Liver, B cells, T cells, Endothelial

FMA organs/tissues related to Ossifying Fibroma:

16
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6CDC73, GNAS, JAG2, NOTCH1, NOTCH3
2MP:00053708.3CDC73, GNAS, JAG1, MDM2, NOTCH1
3MP:00053818.1CDC73, JAG1, JAG2, MDM2, NOTCH1
4MP:00028738.0GNAS, JAG1, MDM2, NOTCH1, NOTCH3
5MP:00053827.9GNAS, JAG1, JAG2, MDM2, NOTCH1
6MP:00053777.7GNAS, JAG1, JAG2, NOTCH1, NOTCH3
7MP:00053807.7CDC73, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
8MP:00053677.6CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
9MP:00053847.6CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
10MP:00053877.5CDC73, GNAS, JAG2, MDM2, NOTCH1, NOTCH3
11MP:00053697.5CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
12MP:00053857.3CDC73, GNAS, JAG1, MDM2, NOTCH1, NOTCH3
13MP:00053797.3CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
14MP:00107717.2CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
15MP:00053907.2GNAS, JAG1, JAG2, MDM2, NOTCH1, NOTCH3
16MP:00036317.2CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
17MP:00053767.1CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
18MP:00107687.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
19MP:00053787.0CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1
20MP:00053976.5CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Cranial juvenile psammomatoid ossifying fibroma: case report. (26588460)
2016
2
Juvenile ossifying fibroma of the maxilla: a case report. (25838672)
2015
3
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
4
An unusual presentation of peripheral ossifying fibroma in an elderly man. (24925549)
2014
5
Juvenile ossifying fibroma of the middle turbinate. (25075725)
2014
6
Ossifying fibroma in the sinonasal tract: a rare case report. (25302205)
2014
7
Retrospective Analysis of Ossifying Fibroma of Jaw Bones Over a Period of 10 Years with Literature Review. (26225029)
2014
8
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
9
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
10
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
11
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
12
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
13
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
14
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
15
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
16
Placement of implants in an ossifying fibroma defect obliterated with demineralized, freeze-dried bone allograft and Plasma-rich growth factor. (23633812)
2012
17
Trabecular and psammomatoid juvenile ossifying fibroma of the skull base mimicking psammomatoid meningioma. (20953744)
2011
18
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
19
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
20
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
21
A case report of cemento-ossifying fibroma. (22190782)
2010
22
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
23
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
24
Giant ossifying fibroma complicated by mucocele of sphenoid sinus--case report. (19105117)
2008
25
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
26
Case of the month: peripheral ossifying fibroma. (18546612)
2008
27
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
28
Ossifying fibroma of long bones in adults: a case report. (17260623)
2006
29
Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). (16407489)
2006
30
Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. (16632273)
2006
31
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
32
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
33
Ossifying fibroma of the jaw. (15372914)
2004
34
Psammomatoid ossifying fibroma of the ethmoid. (12784573)
2003
35
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
36
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
37
Peripheral ossifying fibroma of the maxillary gingiva. (11806482)
2001
38
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space. (10543652)
1999
39
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
40
Maxillary sinus ossifying fibroma. (9395021)
1997
41
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
42
Ossifying fibroma of the skull: clinical and therapeutic study. (8191602)
1994
43
Giant ossifying fibroma. Case report on a bimaxillary presentation. (1402053)
1992
44
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
45
Ossifying fibroma of the jaws: a case report. (1765021)
1991
46
Case presentation: ossifying fibroma. (1820513)
1991
47
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
48
Giant ossifying fibroma of the nasal cavity with intracranial extension. (7246283)
1981
49
Ossifying fibroma in a greater kudu. (411210)
1977
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.3NOTCH1, NOTCH3
28.8MDM2, NOTCH1, NOTCH3
38.8MDM2, NOTCH1, NOTCH3
4
Show member pathways
8.6JAG1, JAG2, NOTCH1
5
Show member pathways
8.6JAG1, JAG2, NOTCH1
68.6JAG1, JAG2, NOTCH1
7
Show member pathways
8.1JAG1, JAG2, MDM2, NOTCH1
88.1JAG1, JAG2, NOTCH1, NOTCH3
9
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
10
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
11
Show member pathways
8.1JAG1, JAG2, NOTCH1, NOTCH3
12
Show member pathways
7.5JAG1, JAG2, MDM2, NOTCH1, NOTCH3
13
Show member pathways
6.4CDC73, GNAS, JAG1, JAG2, MDM2, NOTCH1

GO Terms for genes affiliated with Ossifying Fibroma

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Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Notch signaling pathwayGO:00457479.9JAG2, NOTCH1
2forebrain developmentGO:00309009.8NOTCH1, NOTCH3
3neuron fate commitmentGO:00486639.8NOTCH1, NOTCH3
4endocardial cushion morphogenesisGO:00032039.8MDM2, NOTCH1
5cell communicationGO:00071549.8JAG1, JAG2
6blood vessel remodelingGO:00019749.7JAG1, MDM2
7Notch signaling involved in heart developmentGO:00613149.6JAG1, NOTCH1
8response to muramyl dipeptideGO:00324959.6JAG1, NOTCH1
9pulmonary valve morphogenesisGO:00031849.6JAG1, NOTCH1
10keratinocyte differentiationGO:00302169.6JAG1, NOTCH1
11neuronal stem cell population maintenanceGO:00971509.6JAG1, NOTCH1
12positive regulation of osteoblast differentiationGO:00456699.5GNAS, JAG1
13regulation of cell migrationGO:00303349.4JAG1, NOTCH1
14Notch receptor processingGO:00072209.3JAG2, NOTCH1, NOTCH3
15cell differentiationGO:00301549.2JAG2, NOTCH1, NOTCH3
16cardiac septum morphogenesisGO:00604119.0JAG1, MDM2, NOTCH1
17Notch signaling pathwayGO:00072198.8JAG1, NOTCH1, NOTCH3
18regulation of cell proliferationGO:00421278.6JAG1, JAG2, NOTCH1
19negative regulation of neuron differentiationGO:00456658.6JAG1, NOTCH1, NOTCH3
20multicellular organism developmentGO:00072758.3JAG1, JAG2, NOTCH1
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.1CDC73, JAG1, NOTCH1, NOTCH3

Sources for Ossifying Fibroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet