MCID: OSS001
MIFTS: 47

Ossifying Fibroma malady

Bone diseases, Oral diseases categories

Aliases & Classifications for Ossifying Fibroma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Ossifying Fibroma, Aliases & Descriptions:

Name: Ossifying Fibroma 9 11 60
Fibroma Ossifying 43
 
Fibro-Osteoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Oral diseases


External Ids:

Disease Ontology9 DOID:180
MeSH33 D018214
NCIt38 C8422

Summaries for Ossifying Fibroma

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Disease Ontology:9 A bone benign neoplasm that is located in the mouth and results in an overgrowth of gingival tissue due to irritation or trauma.

MalaCards based summary: Ossifying Fibroma, also known as fibroma ossifying, is related to fibroma and fibrous dysplasia. An important gene associated with Ossifying Fibroma is JAG2 (jagged 2), and among its related pathways are Notch signaling pathway and Dorso-ventral axis formation. The compounds alizarin and titanium have been mentioned in the context of this disorder. Affiliated tissues include the mouth, bone and testes, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Related Diseases for Ossifying Fibroma

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Diseases related to Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma33.1CDC73
2fibrous dysplasia31.3RUNX2, GNAS, BGLAP
3hyperparathyroidism30.9BGLAP, CDC73
4psammomatous meningioma30.8ERCC6
5parathyroid adenoma30.8GNAS, CDC73
6primary hyperparathyroidism30.7CDC73, BGLAP
7giant cell tumor30.6BGLAP, MUC1
8sinusitis10.8
9aneurysmal bone cysts10.6
10aneurysm10.6
11pyogenic granuloma10.5
12chondroblastic osteosarcoma10.5BGLAP
13saethre-chotzen syndrome10.5BGLAP
14aortic valve disease 110.4NOTCH1
15gingivitis10.4
16chondrosarcoma10.3
17neurofibromatosis10.3
18periodontitis10.3
19monostotic fibrous dysplasia10.3
20multiple endocrine neoplasia10.3GNAS, CDC73
21multiple endocrine neoplasia 110.3CDC73, GNAS
22pseudohypoparathyroidism, type ib10.3BGLAP, GNAS
23alagille syndrome10.3JAG1, NOTCH1
24osteitis fibrosa10.3BGLAP, GNAS
25pseudohypoparathyroidism10.3GNAS, BGLAP
26choroid plexus papilloma10.3GFAP
27osteomalacia10.2BGLAP, GNAS
28hyperphosphatemia10.2RUNX2, GNAS
29marchiafava bignami disease10.2BGLAP, RUNX2
30goiter10.2GNAS, BGLAP
31cleidocranial dysplasia10.2BGLAP, RUNX2
32abrikosov's tumor10.2GNAS, MUC1
33brachydactyly10.2GNAS, RUNX2
34skeletal dysplasia multi-gene panels10.2GNAS, RUNX2
35cadasil10.2JAG1, NOTCH3, NOTCH1
36osteopetrosis10.2BGLAP, RUNX2
37buschke-ollendorff syndrome10.2
38retinoblastoma10.2
39neurofibromatosis, type 110.2
40osteoblastoma10.2
41fanconi syndrome10.2
42exophthalmos10.2
43bilateral retinoblastoma10.2
44tuberous sclerosis10.2
45chronic apical periodontitis10.2
46orbital cellulitis10.2
47juxtacortical chondrosarcoma10.2
48adenoma10.2
49cellulitis10.2
50epulis10.2

Graphical network of the top 20 diseases related to Ossifying Fibroma:



Diseases related to ossifying fibroma

Symptoms for Ossifying Fibroma

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Drugs & Therapeutics for Ossifying Fibroma

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Drug clinical trials:

Search ClinicalTrials for Ossifying Fibroma

Search NIH Clinical Center for Ossifying Fibroma

Genetic Tests for Ossifying Fibroma

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Anatomical Context for Ossifying Fibroma

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MalaCards organs/tissues related to Ossifying Fibroma:

31
Bone, Testes, Bone marrow

FMA organs/tissues related to Ossifying Fibroma:

14
The mouth

Animal Models for Ossifying Fibroma or affiliated genes

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MGI Mouse Phenotypes related to Ossifying Fibroma:

35 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2GNAS, JAG2, NOTCH3, JAG1, NOTCH1
2MP:00053679.0NOTCH1, GNAS, JAG1, NOTCH3, CDC73
3MP:00053829.0JAG1, RUNX2, JAG2, NOTCH1, GNAS
4MP:00053808.9NOTCH3, CDC73, NOTCH1, JAG1, JAG2
5MP:00053888.8CDC73, RUNX2, GNAS, JAG2, NOTCH3, NOTCH1
6MP:00053718.7RUNX2, GNAS, JAG2, ERCC6
7MP:00053898.7RUNX2, JAG2, HMMR, NOTCH3, CDC73
8MP:00030128.7MUC1, GNAS, JAG1, RUNX2, JAG2
9MP:00053908.4RUNX2, GNAS, JAG2, JAG1, NOTCH1, NOTCH3
10MP:00020068.4NOTCH1, NOTCH3, HMMR, ERCC6, MUC1
11MP:00053868.3GFAP, GNAS, JAG1, CDC73, ERCC6, NOTCH3
12MP:00053858.3GFAP, RUNX2, CDC73, GNAS, JAG1, NOTCH3
13MP:00053798.2JAG1, NOTCH1, NOTCH3, MUC1, GNAS, RUNX2
14MP:00028738.2NOTCH1, NOTCH3, JAG1, MUC1, GFAP, GNAS
15MP:00053978.1NOTCH3, RUNX2, JAG1, GNAS, JAG2, ERCC6
16MP:00053708.1ERCC6, JAG1, RUNX2, GNAS, NOTCH1, CDC73
17MP:00053818.1MUC1, NOTCH1, CDC73, GFAP, JAG1, JAG2
18MP:00053918.0RUNX2, ERCC6, GFAP, JAG1, MUC1, NOTCH1
19MP:00053697.9RUNX2, NOTCH3, GFAP, GNAS, JAG1, ERCC6
20MP:00053877.9RUNX2, JAG2, GNAS, CDC73, ERCC6, NOTCH3
21MP:00053847.8CDC73, NOTCH1, NOTCH3, GFAP, JAG1, RUNX2
22MP:00053787.8GFAP, GNAS, JAG1, ERCC6, NOTCH3, NOTCH1
23MP:00036317.6ERCC6, NOTCH1, GFAP, GNAS, RUNX2, NOTCH3
24MP:00107687.6CDC73, JAG1, RUNX2, GFAP, GNAS, ERCC6
25MP:00107717.6ERCC6, RUNX2, GNAS, MUC1, JAG1, NOTCH3
26MP:00053767.0NOTCH1, NOTCH3, CDC73, ERCC6, JAG2, MUC1

Publications for Ossifying Fibroma

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Articles related to Ossifying Fibroma:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Juvenile ossifying fibroma of the maxilla: a case report. (25838672)
2015
2
A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. (25649957)
2015
3
An unusual presentation of peripheral ossifying fibroma in an elderly man. (24925549)
2014
4
Juvenile ossifying fibroma of the middle turbinate. (25075725)
2014
5
Ossifying fibroma in the sinonasal tract: a rare case report. (25302205)
2014
6
Laser excision of peripheral ossifying fibroma: Report of two cases. (24872641)
2014
7
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
8
Multicentric peripheral ossifying fibroma: A case report and review of the literature. (24174761)
2013
9
Psammomatoid type juvenile ossifying fibroma of mandible. (23662272)
2013
10
Case presentation of florid cemento-osseous dysplasia with concomitant cemento-ossifying fibroma discovered during implant explantation. (22858018)
2013
11
Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings. (22986252)
2012
12
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
13
Sclerotic masses of the jaws. Ossifying fibroma. (23767153)
2012
14
Placement of implants in an ossifying fibroma defect obliterated with demineralized, freeze-dried bone allograft and Plasma-rich growth factor. (23633812)
2012
15
Asymptomatic ossifying fibroma of the mandible: a case presentation. (22536589)
2012
16
Trabecular and psammomatoid juvenile ossifying fibroma of the skull base mimicking psammomatoid meningioma. (20953744)
2011
17
Oral and maxillofacial pathology case of the month: Trabecular juvenile ossifying fibroma. (21834371)
2011
18
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Maxilla-a Rare Entity. (22654369)
2011
19
Peripheral giant cell granuloma and peripheral ossifying fibroma in children: two case reports. (20134181)
2010
20
A case report of cemento-ossifying fibroma. (22190782)
2010
21
Psammomatoid and trabecular variants of juvenile ossifying fibroma-two case reports. (19881065)
2009
22
Cemento-ossifying Fibroma Of Paranasal Sinus Presenting Acutely As Orbital Cellulitis. (22470655)
2009
23
Giant ossifying fibroma complicated by mucocele of sphenoid sinus--case report. (19105117)
2008
24
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
25
Case of the month: peripheral ossifying fibroma. (18546612)
2008
26
Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. (17268394)
2006
27
Ossifying fibroma of long bones in adults: a case report. (17260623)
2006
28
Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). (16407489)
2006
29
Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. (16632273)
2006
30
An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse. (16814803)
2006
31
Ossifying fibroma of the jugum sphenoidale. (15177408)
2004
32
Ossifying fibroma of the jaw. (15372914)
2004
33
Psammomatoid ossifying fibroma of the ethmoid. (12784573)
2003
34
Oral and maxillofacial pathology case of the month. Central ossifying fibroma. (12725110)
2003
35
Sublabial approach to sinonasal juvenile ossifying fibroma. (12090953)
2002
36
Peripheral ossifying fibroma of the maxillary gingiva. (11806482)
2001
37
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space. (10543652)
1999
38
Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient. (9775467)
1998
39
Maxillary sinus ossifying fibroma. (9395021)
1997
40
Pathologic quiz case 2. Ossifying fibroma of the premaxilla. (8639304)
1996
41
Ossifying fibroma of the skull: clinical and therapeutic study. (8191602)
1994
42
Giant ossifying fibroma. Case report on a bimaxillary presentation. (1402053)
1992
43
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
44
Ossifying fibroma of the jaws: a case report. (1765021)
1991
45
Case presentation: ossifying fibroma. (1820513)
1991
46
Giant ossifying fibroma of the skull. Case report. (6827356)
1983
47
Giant ossifying fibroma of the nasal cavity with intracranial extension. (7246283)
1981
48
Ossifying fibroma in a greater kudu. (411210)
1977
49
Ossifying Fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws. (821512)
1976
50
Ossifying fibroma of the frontal bone. (5900436)
1966

Variations for Ossifying Fibroma

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Expression for genes affiliated with Ossifying Fibroma

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Search GEO for disease gene expression data for Ossifying Fibroma.

Pathways for genes affiliated with Ossifying Fibroma

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Pathways related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8JAG1, NOTCH1
29.8NOTCH1, NOTCH3
3
Show member pathways
9.8NOTCH1, NOTCH3
49.7BGLAP, RUNX2
59.7BGLAP, RUNX2
6
Show member pathways
Development Notch Signaling Pathway58
Transcription Sin3 and NuRD in transcription regulation58
9.6JAG1, JAG2, NOTCH1
7
Show member pathways
9.6NOTCH1, JAG2, JAG1
89.5JAG1, NOTCH3, NOTCH1
99.4RUNX2, BGLAP, GNAS
109.3NOTCH1, BGLAP, RUNX2
119.3NOTCH1, NOTCH3, GFAP
129.3NOTCH1, NOTCH3, GFAP
13
Show member pathways
Notch signaling pathway36
9.3NOTCH1, NOTCH3, JAG2, JAG1
14
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.3JAG1, JAG2, NOTCH3, NOTCH1
15
Show member pathways
9.3NOTCH1, NOTCH3, JAG2, JAG1
169.0JAG1, JAG2, NOTCH3, NOTCH1, CDC73
178.9NOTCH1, NOTCH3, JAG2, JAG1, RUNX2
18
Show member pathways
8.4GFAP, GNAS, JAG1, JAG2, NOTCH3, NOTCH1
198.2ODAM, JAG1, JAG2, HMMR, NOTCH1

Compounds for genes affiliated with Ossifying Fibroma

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1alizarin4310.1BGLAP, RUNX2
2titanium439.9RUNX2, BGLAP
3alendronate43 49 1211.8BGLAP, RUNX2
4eosin439.7GFAP, MUC1
5s 100439.7GFAP, MUC1
6reticulin439.6MUC1, GFAP
7ribonucleic acid439.3MUC1, GNAS, RUNX2
8acth439.2MUC1, GFAP, GNAS
9pge2439.2GNAS, BGLAP, RUNX2, HMMR
10matrigel439.1MUC1, GFAP, NOTCH1
11arginine439.1BGLAP, GNAS, NOTCH3, GFAP
12butyrate438.9RUNX2, GFAP, MUC1
13thymidine43 249.9RUNX2, MUC1, GFAP, GNAS
14alanine438.9GFAP, BGLAP, RUNX2, GNAS
15cyclic amp43 249.9MUC1, RUNX2, GFAP, GNAS
16nitric oxide43 24 1210.8GNAS, RUNX2, JAG1, MUC1, NOTCH1
17cysteine438.7NOTCH3, MUC1, GNAS, GFAP, BGLAP
18dexamethasone43 49 28 1211.6GFAP, RUNX2, BGLAP, NOTCH1, MUC1
19vegf438.6RUNX2, BGLAP, GFAP, MUC1, NOTCH1
20oxygen43 249.6MUC1, GNAS, GFAP, RUNX2, NOTCH1
21threonine438.5NOTCH1, MUC1, GNAS, GFAP
22estrogen438.5BGLAP, NOTCH1, MUC1, GFAP, RUNX2
23retinoic acid43 249.5NOTCH1, RUNX2, BGLAP, GFAP, MUC1
24glutamate438.5NOTCH1, GNAS, ERCC6, GFAP
25lipid438.5NOTCH1, GNAS, MUC1, GFAP, RUNX2
26serine438.2NOTCH1, MUC1, GFAP, BGLAP, GNAS, RUNX2
27tyrosine438.0HMMR, GNAS, GFAP, RUNX2, NOTCH1, MUC1
28calcium43 49 24 1211.0RUNX2, GFAP, GNAS, BGLAP, NOTCH1, NOTCH3

GO Terms for genes affiliated with Ossifying Fibroma

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Cellular components related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7NOTCH1, NOTCH3, JAG1, ODAM, GNAS, BGLAP
2cytoplasmGO:00057377.0GFAP, GNAS, ODAM, MUC1, HMMR, NOTCH3

Biological processes related to Ossifying Fibroma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1auditory receptor cell fate commitmentGO:000991210.2NOTCH1, JAG2
2distal tubule developmentGO:007201710.1NOTCH1, JAG1
3negative regulation of stem cell differentiationGO:0200073710.1NOTCH1, JAG1
4cardiac septum morphogenesisGO:006041110.1NOTCH1, JAG1
5pulmonary valve morphogenesisGO:000318410.1JAG1, NOTCH1
6Notch signaling involved in heart developmentGO:006131410.1NOTCH1, JAG1
7response to muramyl dipeptideGO:003249510.1NOTCH1, JAG1
8neuronal stem cell maintenanceGO:009715010.1JAG1, NOTCH1
9T cell differentiationGO:003021710.0JAG2, RUNX2
10osteoblast developmentGO:000207610.0BGLAP, RUNX2
11embryonic cranial skeleton morphogenesisGO:00487019.9RUNX2, GNAS
12endochondral ossificationGO:00019589.9GNAS, RUNX2
13embryonic hindlimb morphogenesisGO:00351169.9GNAS, NOTCH1
14negative regulation of neuron differentiationGO:00456659.9NOTCH3, JAG1
15bone developmentGO:00603489.9GNAS, BGLAP
16keratinocyte differentiationGO:00302169.8JAG1, NOTCH1
17forebrain developmentGO:00309009.7NOTCH1, NOTCH3
18regulation of cell migrationGO:00303349.6JAG1, JAG2
19Notch receptor processingGO:00072209.6NOTCH1, NOTCH3, JAG2, JAG1
20transcription initiation from RNA polymerase II promoterGO:00063679.6NOTCH1, NOTCH3, RUNX2
21Notch signaling pathwayGO:00072199.6JAG1, JAG2, NOTCH3, NOTCH1
22odontogenesis of dentin-containing toothGO:00424759.3RUNX2, ODAM, JAG2

Molecular functions related to Ossifying Fibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051129.6JAG2, JAG1
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.4MUC1, RUNX2
3calcium ion bindingGO:00055098.9NOTCH1, NOTCH3, JAG2, JAG1, BGLAP
4protein bindingGO:00055157.1RUNX2, GNAS, MUC1, JAG1, JAG2, ERCC6

Products for genes affiliated with Ossifying Fibroma

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Sources for Ossifying Fibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet