Aliases & Classifications for Osteitis Fibrosa

MalaCards integrated aliases for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 51 14
Osteitis Fibrosa Cystica 41 69
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 41 D010002
NCIt 46 C34875
UMLS 69 C0029405

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to mccune-albright syndrome and renal osteodystrophy. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Presynaptic function of Kainate receptors. The drugs Etidronic acid and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and kidney.

Wikipedia : 72 Osteitis fibrosa cystica (/ˌɒstiˈaɪtɪs faɪˈbroʊsə ˈsɪstɪkə/ OS-tee-AY-tis fy-BROH-sə SIS-tik-ə), is a... more...

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome 32.1 BGLAP GNAS
2 renal osteodystrophy 31.6 BGLAP CALCA CASR PTH
3 pseudohypoparathyroidism, type ib 31.3 BGLAP GNAS PTH
4 giant cell tumor 30.5 BGLAP CALCA
5 hyperparathyroidism 30.3 BGLAP CALCA CASR PTH
6 osteomalacia 30.3 BGLAP CALCA CASR
7 primary hyperparathyroidism 30.1 BGLAP CALCA CASR PTH
8 calciphylaxis 30.0 CASR PTH
9 parathyroid adenoma 29.9 BGLAP CALCA CASR PTH
10 pseudohypoparathyroidism 29.8 BGLAP GNAS PTH
11 secondary hyperparathyroidism of renal origin 29.7 BGLAP CALCA CASR PTH
12 hypercalcemia, infantile, 1 29.6 CALCA CASR PTH
13 osteoporosis 28.6 BGLAP CALCA CASR IL6 PTH
14 monostotic fibrous dysplasia 11.2
15 bone inflammation disease 11.0
16 adenoma 10.5
17 osteoporosis, juvenile 10.3 BGLAP CALCA
18 nontoxic goiter 10.3 BGLAP CALCA
19 bullous impetigo 10.3 CALCA IL6
20 impetigo 10.2 CALCA IL6
21 axial osteomalacia 10.2 BGLAP PTH
22 extraskeletal chondroma 10.2 BGLAP PTH
23 hemiplegia 10.2 BGLAP CALCA
24 impaired renal function disease 10.2 BGLAP PTH
25 fibrogenesis imperfecta ossium 10.2 CALCA PTH
26 nodular goiter 10.2 CALCA IL6
27 ischemic bone disease 10.2 BGLAP PTH
28 complex regional pain syndrome 10.2 CALCA IL6
29 cohen-gibson syndrome 10.2
30 thyroiditis 10.2
31 cloacogenic carcinoma 10.2 CALCA PTH
32 metaphyseal chondrodysplasia, jansen type 10.2 CALCA PTH
33 multiple endocrine neoplasia, type iia 10.1 CALCA PTH
34 nutritional deficiency disease 10.1 BGLAP IL6
35 osteonecrosis 10.1 BGLAP PTH
36 thyroid gland disease 10.1 CALCA PTH
37 hypophosphatemia 10.1 BGLAP PTH
38 juvenile rheumatoid arthritis 10.1 BGLAP IL6
39 idiopathic hypercalciuria 10.1 BGLAP CASR
40 hyperparathyroidism 2 with jaw tumors 10.1
41 solitary bone cyst 10.1
42 rickets 10.1
43 hypocalciuric hypercalcemia, familial, type ii 10.0 CASR PTH
44 familial hypocalciuric hypercalcemia 10.0 CASR PTH
45 osseous heteroplasia, progressive 10.0 BGLAP GNAS
46 end stage renal failure 10.0 IL6 PTH
47 osteofibrous dysplasia 10.0 BGLAP GNAS
48 hypophosphatasia, adult 10.0 BGLAP CALCA PTH
49 glucocorticoid-induced osteoporosis 10.0 BGLAP CALCA PTH
50 bone remodeling disease 9.9 BGLAP CALCA PTH

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Drugs for Osteitis Fibrosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 2809-21-4, 7414-83-7 3305
2 Bone Density Conservation Agents Phase 2, Phase 3
3 calcium channel blockers Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5 Diphosphonates Phase 2, Phase 3
6 Risedronate Sodium Phase 2, Phase 3 115436-72-1
7 Hormone Antagonists Phase 3,Phase 2,Phase 1
8 Hormones Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
10
Testolactone Approved, Investigational Phase 2 968-93-4 13769
11
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
12
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
13
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
14 Antineoplastic Agents, Hormonal Phase 2
15 Aromatase Inhibitors Phase 2,Phase 1
16 Estrogens Phase 2,Phase 1
17 Estrogen Antagonists Phase 2,Phase 1
18 Steroid Synthesis Inhibitors Phase 2,Phase 1
19 Estrogen Receptor Antagonists Phase 2
20 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
21
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
22
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
23
Histamine Phosphate 51-74-1 65513
24 Neurotransmitter Agents

Interventional clinical trials:

(show all 18)

# Name Status NCT ID Phase Drugs
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
3 TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE Unknown status NCT01791842 Phase 2 Tocilizumab;Placebo
4 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
5 Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
6 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
7 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
8 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Not yet recruiting NCT02743377 Phase 1, Phase 2
9 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
10 Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome Completed NCT00001973
11 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
12 Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
13 Natural History of Cherubism Observational Study Completed NCT01916772
14 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
15 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Recruiting NCT02868645
16 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
17 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
18 Genetic and Functional Analysis of Cherubism Recruiting NCT01630447

Search NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

18
Bone

MalaCards organs/tissues related to Osteitis Fibrosa:

38
Bone, Kidney, Bone Marrow, Brain, Thyroid, T Cells, Skin

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 154)
# Title Authors Year
1
Osteitis Fibrosa Cystica. ( 29415233 )
2018
2
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. ( 28900835 )
2017
3
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. ( 28554885 )
2017
4
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. ( 29386822 )
2017
5
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. ( 27030464 )
2016
6
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
7
Osteitis fibrosa cystica. ( 27238197 )
2016
8
Osteitis fibrosa cystica in primary hyperparathyroidism. ( 26261355 )
2015
9
Brown tumors: severe osteitis fibrosa cystica. ( 25939949 )
2015
10
Osteitis fibrosa cystica in a domestic young cat. ( 28491388 )
2015
11
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. ( 25511968 )
2015
12
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. ( 25828738 )
2015
13
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. ( 23365170 )
2013
14
Osteitis fibrosa cystica mistaken for malignant disease. ( 23799171 )
2013
15
Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica. ( 23858315 )
2013
16
Successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. ( 23259108 )
2012
17
Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica. ( 21584419 )
2011
18
A rare case of primary hyperparathyroidism and osteitis fibrosa cystica. ( 20919975 )
2010
19
Visual vignette. Osteitis fibrosa cystica. ( 18753115 )
2008
20
Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. ( 18635661 )
2008
21
Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. ( 18702368 )
2008
22
Osteitis fibrosa cystica and secondary hyperparathyroidism in multiple myeloma. ( 17062009 )
2007
23
Oxyphilic cell adenoma of parathyroid resulting in primary hyperparathyroidism and osteitis fibrosa cystica--a case report. ( 17001919 )
2006
24
Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. ( 15168133 )
2004
25
Osteitis fibrosa cystica, coeliac disease and Turner syndrome. A case report. ( 15285529 )
2004
26
Radiology quiz case 2: metastatic calcifications of the middle and external ear and osteitis fibrosa of the temporal bones as a result of secondary hyperparathyroidism. ( 11926927 )
2002
27
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. ( 12490858 )
2002
28
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. ( 11743611 )
2002
29
False positive 99mTc sestamibi scans in patients with osteitis fibrosa cystica and brown tumours. ( 11716445 )
2001
30
Tc99m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. ( 11701666 )
2001
31
Effect of parathyroid adenoma resection on bone density in primary hyperparathyroidism and osteitis fibrosa cystica. ( 11688767 )
2001
32
Images in haematology. Osteitis fibrosa cystica generalisata with adult T-cell leukaemia: a case report. ( 11054056 )
2000
33
Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report. ( 10606900 )
1999
34
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. ( 10594779 )
1999
35
Comment on marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9768702 )
1998
36
Osteitis fibrosa cystica with renal parathyroid hormone resistance: a review of pseudohypoparathyroidism with insight into calcium homeostasis. ( 9637471 )
1998
37
NPS R-568 halts or reverses osteitis fibrosa in uremic rats. ( 9461105 )
1998
38
Osteitis fibrosa: treatment trends. ( 9543904 )
1998
39
Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9506717 )
1998
40
Osteitis fibrosa cystica and chronic renal failure. ( 9158318 )
1997
41
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. ( 9015472 )
1996
42
Intravenous calcitriol can increase bone mass in hemodialysis patients with osteitis fibrosa. ( 7565429 )
1995
43
Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: report of a case. ( 8292854 )
1993
44
Inhibition of 1,25(OH)2D production by hypercalcemia in osteitis fibrosa cystica: influence on parathyroid hormone secretion and hungry bone disease. ( 8274876 )
1993
45
Case management of the anemic patient: epoetin alfa--focus on osteitis fibrosa. ( 8285805 )
1993
46
Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. ( 8249919 )
1993
47
Pseudohypoparathyroidism with osteitis fibrosa cystica: direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. ( 8427051 )
1993
48
Osteitis fibrosa cystica (brown tumor) in a patient with renal transplantation. Report of a case with aspiration cytodiagnosis. ( 1636352 )
1992
49
Current advances in the therapy of secondary hyperparathyroidism and osteitis fibrosa. ( 1813787 )
1991
50
Osteitis fibrosa cystica (brown tumor) of the spine with cord compression: report of a case with needle aspiration biopsy findings. ( 2292220 )
1990

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

Pathways for Osteitis Fibrosa

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 BGLAP CALCA GNAS IL6 PTH

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.88 CALCA CASR GNAS PTH
2 regulation of receptor activity GO:0010469 9.77 CALCA IL6 PTH
3 response to drug GO:0042493 9.71 BGLAP GNAS PTH
4 skeletal system development GO:0001501 9.61 BGLAP GNAS PTH
5 response to glucocorticoid GO:0051384 9.58 BGLAP IL6
6 positive regulation of osteoblast differentiation GO:0045669 9.57 GNAS IL6
7 response to nutrient levels GO:0031667 9.56 BGLAP PTH
8 bone development GO:0060348 9.55 BGLAP GNAS
9 monocyte chemotaxis GO:0002548 9.52 CALCA IL6
10 activation of adenylate cyclase activity GO:0007190 9.51 CALCA GNAS
11 cellular calcium ion homeostasis GO:0006874 9.5 CALCA CASR PTH
12 vasodilation GO:0042311 9.49 CALCA CASR
13 response to vitamin D GO:0033280 9.48 BGLAP PTH
14 positive regulation of ossification GO:0045778 9.46 CALCA PTH
15 negative regulation of bone resorption GO:0045779 9.4 CALCA IL6
16 cellular response to vitamin D GO:0071305 9.37 BGLAP CASR
17 response to fibroblast growth factor GO:0071774 9.26 CASR PTH
18 response to parathyroid hormone GO:0071107 9.16 GNAS PTH
19 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.13 CALCA GNAS PTH
20 positive regulation of cAMP biosynthetic process GO:0030819 8.8 CALCA GNAS PTH

Sources for Osteitis Fibrosa

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