Aliases & Classifications for Osteitis Fibrosa

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Osteitis Fibrosa, Aliases & Descriptions:

Name: Osteitis Fibrosa 9 11 43
Osteitis Fibrosa Cystica Generalisata 9
Von Recklinghausen's Bone Disease 9
 
Hyperparathyroid Bone Disease 9
Osteitis Fibrosa Disseminata 60
Osteitis Fibrosa Cystica 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:3341
MeSH33 D010002
NCIt38 C34875

Summaries for Osteitis Fibrosa

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Disease Ontology:9 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary: Osteitis Fibrosa, also known as osteitis fibrosa cystica generalisata, is related to adenoma and giant cell tumor. An important gene associated with Osteitis Fibrosa is PDLIM3 (PDZ and LIM domain 3), and among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Adenylate cyclase activating neuropeptides. The compounds 22-oxacalcitriol and thiazide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and kidney, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Related Diseases for Osteitis Fibrosa

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Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1GNAS, PTH, CASR, CALCA
2giant cell tumor31.0CALCA, BGLAP
3primary hyperparathyroidism31.0BGLAP, PTH, CASR, CALCA, ALPP
4pseudohypoparathyroidism30.9BGLAP, GNAS, PTH, CALCA
5fibrous dysplasia30.9BGLAP, GNAS
6rickets30.6BGLAP, PTH, CASR, ALPP
7uremia30.4B2M, PTH, CASR
8osteoporosis30.3BGLAP, PTH, IL11, CALCA
9parathyroid adenoma30.1ALPP, ALPL, ALPPL2, CALCA, CASR, PTH
10hyperparathyroidism30.0KNTC1, ALPP, ALPL, ALPPL2, CALCA, CASR
11calcinosis29.9PTH, CASR, ALPPL2, ALPL, ALPP
12myeloma29.6B2M, BGLAP, IL11, ALPPL2, ALPL, ALPP
13osteomalacia29.2CALCA, CASR, PTH, GNAS, BGLAP, ALPPL2
14hypercalcemia29.2CALCA, CASR, PTH, BGLAP, B2M, ALPPL2
15renal osteodystrophy29.1PTH, BGLAP, KNTC1, ALPP, ALPL, ALPPL2
16chronic pyelonephritis10.5B2M
17mccune-albright syndrome, somatic, mosaic10.5
18pyelonephritis10.5B2M
19solitary bone cyst10.4
20thyroiditis10.4
21parathyroid gland disease10.4CASR, PTH
22parathyroid carcinoma10.4PTH, CASR
23cherubism10.4CALCA
24brachydactyly10.3GNAS, PTH
25spondyloarthropathy 110.3PTH, BGLAP
26idiopathic juvenile osteoporosis10.3BGLAP, CALCA
27pseudohypoparathyroidism, type ib10.3BGLAP, GNAS, PTH
28nephrolithiasis10.3PTH, CASR
29multiple endocrine neoplasia iia10.3CALCA, PTH
30multinodular goiter10.3CALCA, GNAS
31autosomal dominant disease10.2PTH, CALCA
32multiple endocrine neoplasia 110.2GNAS, PTH, CASR
33metabolic acidosis10.2B2M, BGLAP, PTH
34hyperparathyroidism-jaw tumor syndrome10.2
35multiple myeloma10.2
36ameloblastoma10.2
37neurofibromatosis10.2
38calciphylaxis10.2
39cranial nerve palsy10.2
40liposarcoma10.2
41paraplegia10.2
42periostitis10.2
43turner syndrome10.2
44dwarfism10.2
45precocious puberty10.2
46nephritis10.2
47monostotic fibrous dysplasia10.2
48hypothyroidism10.2GNAS, PTH, CASR
49germ cell cancer10.2ALPPL2, ALPP
50endodermal sinus tumor10.2ALPP, ALPPL2

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to osteitis fibrosa

Symptoms for Osteitis Fibrosa

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Drugs & Therapeutics for Osteitis Fibrosa

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Drug clinical trials:

Search ClinicalTrials for Osteitis Fibrosa

Search NIH Clinical Center for Osteitis Fibrosa

Genetic Tests for Osteitis Fibrosa

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Anatomical Context for Osteitis Fibrosa

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MalaCards organs/tissues related to Osteitis Fibrosa:

31
Bone, Kidney, Thyroid, T cells, Skin

FMA organs/tissues related to Osteitis Fibrosa:

14
Bone

Animal Models for Osteitis Fibrosa or affiliated genes

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MGI Mouse Phenotypes related to Osteitis Fibrosa:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7ALPL, CALCA, CASR, PTH, GNAS
2MP:00053798.4B2M, GNAS, PTH, CASR, ALPL
3MP:00053858.3B2M, GNAS, PTH, CALCA, ALPL, PDLIM3
4MP:00053767.9B2M, GNAS, PTH, CASR, CALCA, ALPL
5MP:00107687.6PDLIM3, B2M, GNAS, PTH, CASR, CALCA

Publications for Osteitis Fibrosa

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Articles related to Osteitis Fibrosa:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. (25828738)
2015
2
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. (23365170)
2013
3
Successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. (23259108)
2012
4
Visual vignette. Osteitis fibrosa cystica. (18753115)
2008
5
Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. (18702368)
2008
6
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
7
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. (12490858)
2002
8
Tc99m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. (11701666)
2001
9
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. (10594779)
1999
10
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. (9015472)
1996
11
Case management of the anemic patient: epoetin alfa--focus on osteitis fibrosa. (8285805)
1993
12
Parathyroid hormone-like bioactivity in a patient with severe osteitis fibrosa cystica due to malignancy: renotropic actions of a tumour extract as assessed by cytochemical bioassay. (4039233)
1985
13
Advanced osteitis fibrosa cystica in the absence of phalangeal subperiosteal resorption. A case report and review of the literature. (3966183)
1985
14
Hyperparathyroidism with osteitis fibrosa cystica in the maxilla. (6715975)
1984
15
Healing of osteitis fibrosa cystica after partial parathyroidectomy despite persistent parathyroid hyperfunction: a case report. (7154936)
1982
16
The first recorded case of osteitis fibrosa cystica. (7471024)
1981
17
Biological activity of endogenous and exogenous calcitonin in patients with osteitis fibrosa and chronic renal failure. (740683)
1978
18
Dialysate calcium levels, dialysis hours and the healing of osteitis fibrosa. (1067489)
1976
19
Dietary induction of osteitis fibrosa cystica in the rat: roles of parathyroid hormone and calcitonin. (953813)
1976
20
Osteitis fibrosa (brown tumor) of the maxilla. (4437251)
1974
21
Normacalcaemic primary hyperparathyroidism with osteitis fibrosa. (5138753)
1971
22
Comparison between the results of radiocalcium studies and histological findings in a case of primary hyperparathyroidism (osteitis fibrosa cystica generalisata of von Recklinghausen) before and after removal of parathyroid adenoma. (5921154)
1966
23
Parathyroid tumour with osteitis fibrosa cystica. Case report with review. (13984952)
1962
24
Osteitis fibrosa induced by calciphylaxis in the absence of the parathyroids. (13910518)
1962
25
Parathyroid hyperplasia, multicystic kidneys, osteitis fibrosa generalisata and metastatic calcification in cirrhotic rats fed N-2-fluorenyldiacetamide. (13981802)
1962
26
Clinicopathologic conference; polycystic kidneys with generalized osteitis fibrosa cystica and parathyroid hyperplasia. (14909823)
1952
27
Osteoporosis, osteomalacia and osteitis fibrosa cystica, with special reference to the parathyroid and calcium metabolism. (14885642)
1951
28
A case of diffuse osteitis fibrosa with remodelling of the jaw by intra-oral approach. (14895776)
1951
29
Benign giant cell tumor or localized osteitis fibrosa cystica. (14846598)
1950
30
Localized osteitis fibrosa cystica of the frontal bone; report of a case. (15400099)
1950
31
Report of a case of long standing renal insufficiency with extensive metastatic calcifications (renal osteitis fibrosa cystica). (14771322)
1950
32
Hyperplasia of the parathyroids associated with osteitis fibrosa in rats treated with thiouracil and related compounds. (18128092)
1949
33
A case of osteitis fibrosa cystica. (18124462)
1949
34
Bony tumour of maxilla; osteitis fibrosa? (18903334)
1948
35
The clinical pathology of osteitis fibrosa. (18934700)
1948
36
Three Cysts in the Same Mandible, Not of Dental Origin. ? Solitary Cysts or Osteitis Fibrosa. (19993660)
1947
37
Three Cysts in the Same Mandible, Not of Dental Origin.A ? Solitary Cysts or Osteitis Fibrosa. (20918057)
1947
38
Chronic Hyperplasia or Focal Osteitis Fibrosa of the Maxilla: (Section of Laryngology). (19992334)
1941
39
Osteitis Fibrosa of Left Superior Maxilla. (19992021)
1939
40
Osteitis Fibrosa of Left Upper Jaw Involving Base of Skull. Osteitis Deformans of Spine. (19992022)
1939
41
VI.-General Osteitis Fibrosa: Parathyroidectomy. (19991713)
1938
42
Generalized Osteitis Fibrosa. Rapid Recalcification of Bone after Complete Parathyroidectomy. (19990406)
1935
43
Osteitis Fibrosa of Maxilla and Cranium: (Section of Odontology). (19990491)
1935
44
(?) Diffuse Osteitis Fibrosa with Spontaneous Fracture of the Left Femur. (19989736)
1934
45
Solitary Bone Cyst: The Localized from of Osteitis Fibrosa Cystica. (17867151)
1934
46
Hyperparathyroidism: Generalized Osteitis Fibrosa with Multiple Osteoclastomata. (19987984)
1931
47
OSTEITIS FIBROSA WITH INITIAL SYMPTOMS RESEMBLING RHEUMATIC INFECTION: REPORT OF CASE. (20775568)
1930
48
A CASE OF OSTEITIS FIBROSA CYSTICA (OSTEOMALACIA?) WITH EVIDENCE OF HYPERACTIVITY OF THE PARA-THYROID BODIES. METABOLIC STUDY I. (16693892)
1930
49
OSTEITIS FIBROSA CYSTICA OCCURRING IN A FLAT BONE: Report of a Case. (18739020)
1923
50
VON RECKLINGHAUSEN'S DISEASE OR OSTEITIS FIBROSA: WITH REPORT OF A CASE PRESENTING MULTIPLE CYSTS AND GIANT-CELL TUMORS. (17864590)
1922

Variations for Osteitis Fibrosa

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Expression for genes affiliated with Osteitis Fibrosa

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Search GEO for disease gene expression data for Osteitis Fibrosa.

Pathways for genes affiliated with Osteitis Fibrosa

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Pathways related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CASR, GNAS
29.7CALCA, GNAS
39.6IL11, BGLAP
49.5PTH, GNAS, BGLAP
59.5BGLAP, PTH, CALCA
69.4CALCA, PTH, GNAS
7
Show member pathways
9.4CALCA, PTH, GNAS
8
Show member pathways
9.1GNAS, PTH, CASR, CALCA
9
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde36
NAD salvage36
NAD metabolism58
9.0ALPP, ALPL, ALPPL2
109.0ALPP, ALPL, ALPPL2

Compounds for genes affiliated with Osteitis Fibrosa

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Compounds related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
122-oxacalcitriol439.7BGLAP, CASR, ALPP
2thiazide439.7BGLAP, CALCA, CASR
3ipriflavone439.7BGLAP, ALPP, CALCA
424,25-dihydroxyvitamin d3439.6BGLAP, ALPP, CALCA
5etidronate439.6BGLAP, CALCA, ALPP
6tartrate439.6BGLAP, ALPP, CALCA
7vitamin k2439.6ALPP, BGLAP, CALCA
8sodium fluoride439.6ALPP, BGLAP, CALCA
9alizarin439.5ALPP, ALPL, BGLAP
10risedronate43 49 28 59 1213.5CALCA, ALPP, BGLAP
11acth439.5IL11, GNAS
12pyridinoline439.4BGLAP, ALPP, CALCA
13zoledronic acid439.4CALCA, ALPP, BGLAP
14pmma439.4ALPP, CALCA, B2M
157,8-dihydroneopterin43 2410.4ALPPL2, ALPL, ALPP
16dihydroxyacetone43 2410.4ALPL, ALPPL2, ALPP
17dihydroneopterin triphosphate43 2410.4ALPP, ALPPL2, ALPL
18hydroxyproline43 24 1211.3PTH, ALPP, BGLAP, CALCA
194-Nitrophenol249.3ALPP, ALPPL2, ALPL
20Dihydroxyacetone phosphate249.3ALPPL2, ALPL, ALPP
21fluoride439.3CALCA, B2M, BGLAP, ALPP
22levamisole43 1210.3ALPP, ALPPL2, ALPL
23amifostine43 1210.2ALPL, IL11, ALPPL2
24titanium439.2ALPP, BGLAP, IL11
25methimazole43 2 1211.2ALPP, BGLAP, B2M
26calcium carbonate439.0BGLAP, B2M, ALPP, CALCA, PTH
27thyroxine43 2410.0B2M, ALPP, CALCA, PTH, BGLAP
28deoxypyridinoline438.8ALPP, PTH, IL11, CALCA, BGLAP
29alendronate43 49 1210.8BGLAP, PTH, ALPP, IL11, CALCA
30forskolin43 49 1210.7CALCA, CASR, IL11, PTH, GNAS
31pamidronate43 49 1210.7BGLAP, CASR, B2M, CALCA, ALPP, PTH
3225-hydroxyvitamin d438.7CASR, B2M, BGLAP, PTH, CALCA, ALPP
33phosphorus438.7PTH, ALPP, CALCA, CASR, B2M, BGLAP
34hydroxyapatite438.7ALPP, IL11, CASR, BGLAP, ALPL
35testosterone43 59 24 1211.6ALPP, PTH, BGLAP, B2M, CALCA
361,25 dihydroxy vitamin d3438.4BGLAP, CALCA, CASR, ALPP, IL11, PTH
37thymidine43 249.4IL11, ALPP, B2M, PTH, GNAS
38creatinine438.4PTH, B2M, CALCA, ALPP, PDLIM3, CASR
39cyclosporin a43 28 5910.3CALCA, ALPP, CASR, IL11, BGLAP, B2M
40cyclic amp43 249.3PTH, ALPPL2, CALCA, CASR, IL11, GNAS
41aspartate438.3BGLAP, B2M, IL11, ALPL, ALPP
42vegf438.3PTH, IL11, ALPP, BGLAP, B2M, CALCA
43alanine438.2GNAS, BGLAP, IL11, B2M, CASR, ALPP
44calcitriol43 59 24 1211.1CASR, IL11, BGLAP, B2M, CALCA, ALPP
45magnesium43 24 1210.1ALPPL2, ALPL, ALPP, PTH, CASR
46estrogen438.0ALPP, CALCA, CASR, IL11, PTH, BGLAP
47cysteine437.9IL11, ALPP, ALPL, GNAS, BGLAP, B2M
48pge2437.7ALPP, PTH, B2M, BGLAP, GNAS, CASR
49vitamin d437.6B2M, IL11, PTH, CASR, ALPL, BGLAP
50calcium43 49 24 1210.0PDLIM3, ALPP, CASR, B2M, BGLAP, GNAS

GO Terms for genes affiliated with Osteitis Fibrosa

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Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:00312258.7ALPP, ALPL, ALPPL2
2extracellular regionGO:00055768.0B2M, BGLAP, GNAS, PTH, IL11, CALCA
3extracellular spaceGO:00056158.0ALPL, CALCA, IL11, PTH, BGLAP, B2M
4plasma membraneGO:00058867.1GNAS, CASR, ALPPL2, ALPL, ALPP, KNTC1

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to parathyroid hormoneGO:007110710.0PTH, GNAS
2response to cadmium ionGO:00466869.9PTH, B2M
3bone developmentGO:00603489.8GNAS, BGLAP
4endochondral ossificationGO:00019589.7GNAS, ALPL
5response to vitamin DGO:00332809.7ALPL, PTH, BGLAP
6positive regulation of cAMP biosynthetic processGO:00308199.7CALCA, PTH, GNAS
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.6GNAS, PTH, CALCA
8activation of adenylate cyclase activityGO:00071909.6CALCA, GNAS
9skeletal system developmentGO:00015019.5ALPL, PTH, BGLAP
10response to drugGO:00424939.3B2M, BGLAP, GNAS, PTH
11cell-cell signalingGO:00072678.9CALCA, IL11, PTH

Molecular functions related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00040359.0ALPP, ALPL, ALPPL2

Products for genes affiliated with Osteitis Fibrosa

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Sources for Osteitis Fibrosa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet