MCID: OST004
MIFTS: 46

Osteitis Fibrosa malady

Bone category

Summaries for Osteitis Fibrosa

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A bone resorption disease that has material basis in hyperparathyroidism which results in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards: Osteitis Fibrosa, also known as osteitis fibrosa cystica generalisata, is related to primary hyperparathyroidism and adenoma. An important gene associated with Osteitis Fibrosa is PDLIM3 (PDZ and LIM domain 3), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds sevelamer and calcium gluconate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and thyroid, and related mouse phenotypes are cardiovascular system and mortality/aging.

Wikipedia:64 Osteitis fibrosa cystica /ˌɒstiːˈaɪtɨs faɪˈbroʊsə ˈsɪstɨkə/, abbreviated OFC, and also... more...

Aliases & Classifications for Osteitis Fibrosa

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

osteitis fibrosa 8 10 45
osteitis fibrosa cystica generalisata 8
von recklinghausen's bone disease 8
hyperparathyroid bone disease 8
osteitis fibrosa disseminata 61


External Ids:

Disease Ontology8 DOID:3341
NCIt40 C34875
MeSH35 D010002

Related Diseases for Osteitis Fibrosa

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism31.1BGLAP, CASR, PTH, ALPP, CALCA
2adenoma31.1PTH, CALCA, CASR, GNAS
3osteomalacia30.8GNAS, KNTC1, PTH, ALPL, ALPP, ALPPL2
4mccune albright syndrome30.6GNAS
5rickets30.5BGLAP, ALPP, PTH, CASR
6renal osteodystrophy30.4BGLAP, CALCA, CASR, KNTC1, PTH, ALPL
7parathyroid carcinoma30.3CASR, PTH
8hypercalcemia30.2ALPPL2, ALPP, ALPL, PTH, B2M, CASR
9osteoporosis30.2ALPPL2, ALPP, ALPL, PTH, IL11, CASR
10uremia30.1B2M, CASR, PTH
11solitary bone cyst10.3
12neurofibromatosis10.2
13oxyphilic adenoma10.2
14calciphylaxis10.2
15turner syndrome10.2
16dwarfism10.2
17char syndrome10.2
18precocious puberty10.2
19nephritis10.2
20lip disease10.2
21monostotic fibrous dysplasia10.2
22bone marrow necrosis10.1
23insulin resistance10.0GNAS
24obesity10.0GNAS
25growth hormone deficiency10.0BGLAP
26peritonitis10.0B2M
27hyperostosis10.0BGLAP
28atherosclerosis10.0CASR
29hyperprolactinemia10.0GNAS
30congenital hypothyroidism10.0GNAS
31leydig cell tumor10.0GNAS
32multiple myeloma10.0B2M
33stomach cancer10.0CASR
34liver cirrhosis10.0IL11
35adenocarcinoma10.0CASR
36thyroiditis10.0CALCA
37gingivitis10.0ALPP
38asthma10.0IL11
39chronic pyelonephritis10.0B2M
40nephrolithiasis10.0CASR, PTH
41essential hypertension10.0GNAS
42hepatitis10.0ALPP
43dysgerminoma10.0ALPP
44sarcoidosis10.0ALPP
45hypoparathyroidism familial isolated10.0CASR, PTH
46pituitary adenoma10.0CASR, GNAS
47short stature10.0BGLAP, GNAS
48acromegaly10.0GNAS, BGLAP
49myelodysplastic syndromes10.0IL11
50craniosynostosis10.0ALPL

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to osteitis fibrosa

Clinical Features for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteitis Fibrosa

Drug clinical trials:

Search ClinicalTrials for Osteitis Fibrosa

Search NIH Clinical Center for Osteitis Fibrosa

Search CenterWatch for Osteitis Fibrosa

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Osteitis Fibrosa:

33
Kidney, Thyroid, Skin, T cells

FMA organs/tissues related to Osteitis Fibrosa:

14
Bone

Animal Models for Osteitis Fibrosa or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Osteitis Fibrosa:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5ALPL, PTH, B2M, PDLIM3, GNAS, CALCA
2MP:00107687.4ALPP, CALCA, CASR, GNAS, PDLIM3, B2M

Publications for Osteitis Fibrosa

Sources:
51PubMed
See all sources

Articles related to Osteitis Fibrosa:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
A rare case of primary hyperparathyroidism and osteitis fibrosa cystica. (20919975)
2010
2
Osteitis fibrosa cystica, coeliac disease and Turner syndrome. A case report. (15285529)
2004
3
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
4
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. (12490858)
2002
5
Comment on marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. (9768702)
1998
6
NPS R-568 halts or reverses osteitis fibrosa in uremic rats. (9461105)
1998
7
Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. (9506717)
1998
8
Osteitis fibrosa cystica and chronic renal failure. (9158318)
1997
9
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. (9015472)
1996
10
Intravenous calcitriol can increase bone mass in hemodialysis patients with osteitis fibrosa. (7565429)
1995
11
Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. (8249919)
1993
12
Osteitis fibrosa cystica (brown tumor) in a patient with renal transplantation. Report of a case with aspiration cytodiagnosis. (1636352)
1992
13
Current advances in the therapy of secondary hyperparathyroidism and osteitis fibrosa. (1813787)
1991
14
Osteitis fibrosa cystica (brown tumor) of the spine with cord compression: report of a case with needle aspiration biopsy findings. (2292220)
1990
15
Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. (2631697)
1989
16
Persistence of bone resorptions following treatment of renal osteitis fibrosa. (3354757)
1988
17
Parathyroid hormone-like bioactivity in a patient with severe osteitis fibrosa cystica due to malignancy: renotropic actions of a tumour extract as assessed by cytochemical bioassay. (4039233)
1985
18
Fine needle aspiration of osteitis fibrosa cystica. (3836078)
1985
19
Dialysate calcium levels, dialysis hours and the healing of osteitis fibrosa. (1067489)
1976
20
Sensorineural deafness due to osteitis fibrosa. (1244830)
1976
21
Renal resistance to parathyroid hormone with hyperphosphatemic osteomalacia and osteitis fibrosa. A case report. (4433369)
1974
22
Successful medical management of osteitis fibrosa due to "tertiary" hyperparathyroidism. (5010725)
1972
23
Role of the parathyroids in the production of osteitis fibrosa and soft tissue calcification by lead acetate. (13987863)
1963
24
Parathyroid hyperplasia, multicystic kidneys, osteitis fibrosa generalisata and metastatic calcification in cirrhotic rats fed N-2-fluorenyldiacetamide. (13981802)
1962
25
Pseudohypoparathyroidism with secondary hyperparathyroidism and osteitis fibrosa. (14457957)
1962
26
Occult malabsorption causing osteitis fibrosa cystica. Report of one case with review. (13885890)
1962
27
Production of osteitis fibrosa by stylomycin aminonucleoside in the parathyroidectomized rat. (13512240)
1958
28
Giant-cell tumor of the mandible associated with hyperparathyroidism and osteitis fibrosa cystica generalisata. (13154918)
1954
29
Parathyroid adenoma with generalized osteitis fibrosa cystica. (13027296)
1953
30
Hyperparathyroidism (generalized osteitis fibrosa). (13063933)
1953
31
A case of diffuse osteitis fibrosa with remodelling of the jaw by intra-oral approach. (14895776)
1951
32
Hyperparathyroidism--osteitis fibrosa cystica parathyroid adenoma--with report of a case. (14880989)
1951
33
Report of a case of long standing renal insufficiency with extensive metastatic calcifications (renal osteitis fibrosa cystica). (14771322)
1950
34
Hyperplasia of the parathyroids associated with osteitis fibrosa in rats treated with thiouracil and related compounds. (18128092)
1949
35
Osteitis fibrosa disseminata. (18124584)
1949
36
Bony tumour of maxilla; osteitis fibrosa? (18903334)
1948
37
A case of localized osteitis fibrosa of the skull. (18895135)
1948
38
Solitary bone cyst of the oscalcis, a form of osteitis fibrosa. (18868077)
1948
39
Three Cysts in the Same Mandible, Not of Dental Origin.A ? Solitary Cysts or Osteitis Fibrosa. (20918057)
1947
40
Regional Osteitis Fibrosa Affecting the Facial Bones: Two Cases. (19993551)
1947
41
Osteitis Fibrosa of Left Superior Maxilla. (19992021)
1939
42
Osteitis Fibrosa of Left Upper Jaw Involving Base of Skull. Osteitis Deformans of Spine. (19992022)
1939
43
HYPERPARATHYROIDISM ASSOCIATED WITH OSTEITIS FIBROSA CYSTICA. (20321251)
1939
44
VI.-General Osteitis Fibrosa: Parathyroidectomy. (19991713)
1938
45
Generalized Osteitis Fibrosa. Rapid Recalcification of Bone after Complete Parathyroidectomy. (19990406)
1935
46
Solitary Bone Cyst: The Localized from of Osteitis Fibrosa Cystica. (17867151)
1934
47
THE EXPERIMENTAL PRODUCTION OF OSTEITIS FIBROSA OSTEOPLASTICA: Von Recklinghausen's Disease of the Bones. (20319372)
1934
48
OSTEITIS FIBROSA WITH INITIAL SYMPTOMS RESEMBLING RHEUMATIC INFECTION: REPORT OF CASE. (20775568)
1930
49
VON RECKLINGHAUSEN'S DISEASE OR OSTEITIS FIBROSA: WITH REPORT OF A CASE PRESENTING MULTIPLE CYSTS AND GIANT-CELL TUMORS. (17864590)
1922
50
Case of Osteitis Fibrosa treated by Resection of 4 in. of Humerus and Insertion of Boiled Beef-bone Graft. (19981587)
1921

Genetic Variations for Osteitis Fibrosa

Expression for genes affiliated with Osteitis Fibrosa

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

Pathways for genes affiliated with Osteitis Fibrosa

Sources:
12EMD Millipore, 30KEGG
See all sources

Pathways related to Osteitis Fibrosa according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.2PTH
2
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.4BGLAP, GNAS, PTH
3
NAD metabolism
Hide members
9.0ALPPL2, ALPP, ALPL
49.0ALPPL2, ALPP, ALPL

Compounds for genes affiliated with Osteitis Fibrosa

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Osteitis Fibrosa according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1sevelamer459.8CASR, BGLAP
2calcium gluconate459.7CALCA, BGLAP
3thiazide459.7CASR, BGLAP, CALCA
422-oxacalcitriol459.6CASR, BGLAP, ALPP
5pmma459.5ALPP, B2M, CALCA
6ipriflavone459.5ALPP, CALCA, BGLAP
724,25-dihydroxyvitamin d3459.5ALPP, CALCA, BGLAP
8etidronate459.5BGLAP, ALPP, CALCA
9tio2459.5ALPP, BGLAP
10vitamin k2459.5ALPP, CALCA, BGLAP
11tartrate459.5BGLAP, ALPP, CALCA
12sodium fluoride459.5CALCA, BGLAP, ALPP
13forskolin45 50 1111.5CALCA, PTH, IL11
14alizarin459.5BGLAP, ALPL, ALPP
15risedronate45 60 50 29 1113.5ALPP, CALCA, BGLAP
167,8-dihydroneopterin45 2410.4ALPPL2, ALPL, ALPP
17dihydroneopterin triphosphate45 2410.4ALPL, ALPP, ALPPL2
18pyridinoline459.4BGLAP, ALPP, CALCA
19dihydroxyacetone45 2410.4ALPPL2, ALPP, ALPL
20zoledronic acid459.4BGLAP, ALPP, CALCA
21methimazole45 2 1111.4B2M, ALPP, BGLAP
22levamisole45 1110.4ALPP, ALPL, ALPPL2
23amifostine45 1110.3ALPL, IL11, ALPPL2
24hydroxyproline45 11 2411.2ALPP, PTH, BGLAP, CALCA
25fluoride459.2CALCA, ALPP, BGLAP, B2M
26deoxypyridinoline459.2BGLAP, CALCA, IL11, PTH
27titanium459.2BGLAP, ALPP, IL11
28creatinine459.1PDLIM3, ALPP, PTH, CASR, BGLAP
29acth459.0CALCA, IL11, CASR, GNAS
30calcium carbonate458.9ALPP, PTH, B2M, CALCA, BGLAP
31thyroxine45 249.9CALCA, BGLAP, ALPP, B2M, PTH
32ribonucleic acid458.8PTH, GNAS, CASR, IL11
33cysteine458.8ALPL, CASR, GNAS, B2M, IL11
34alendronate45 50 1110.7BGLAP, ALPP, PTH, CALCA, IL11
35pamidronate45 50 1110.6CALCA, B2M, CASR, ALPP, PTH, BGLAP
3625-hydroxyvitamin d458.6BGLAP, CASR, B2M, PTH, ALPP, CALCA
37phosphorus458.6B2M, CASR, ALPP, BGLAP, CALCA, PTH
38thymidine45 249.6GNAS, ALPP, PTH, IL11, B2M
39hydroxyapatite458.6IL11, ALPP, CASR, ALPL, BGLAP
40magnesium45 11 2410.4CASR, ALPPL2, ALPP, ALPL, PTH
41cyclic amp45 249.4CASR, CALCA, IL11, GNAS, PTH, ALPPL2
421,25 dihydroxy vitamin d3458.3BGLAP, ALPP, PTH, IL11, CASR, CALCA
43aspartate458.3ALPP, BGLAP, B2M, ALPL, IL11
44cyclosporin a45 29 6010.3BGLAP, ALPP, IL11, B2M, CASR, CALCA
45testosterone45 60 11 2411.2BGLAP, CALCA, B2M, PTH, ALPP
46vegf458.2BGLAP, CALCA, B2M, IL11, PTH, ALPP
47alanine458.1BGLAP, IL11, B2M, GNAS, CASR, ALPP
48calcitriol45 60 11 2411.0CALCA, BGLAP, CASR, B2M, IL11, PTH
49vitamin d457.6ALPL, PTH, BGLAP, CALCA, CASR, B2M
50calcium45 50 11 2410.0ALPL, CALCA, CASR, PDLIM3, B2M, IL11

GO Terms for genes affiliated with Osteitis Fibrosa

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteitis Fibrosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:0312258.7ALPP, ALPPL2, ALPL
2extracellular regionGO:0055768.4BGLAP, CALCA, GNAS, B2M, IL11
3extracellular spaceGO:0056157.9IL11, BGLAP, CALCA, ALPL, PTH, B2M

Biological processes related to Osteitis Fibrosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:0071909.8GNAS, CALCA
2response to vitamin DGO:0332809.6ALPL, BGLAP
3positive regulation of cAMP biosynthetic processGO:0308199.6PTH, GNAS, CALCA
4endochondral ossificationGO:0019589.4ALPL, GNAS
5skeletal system developmentGO:0015019.2BGLAP, PTH, ALPL

Molecular functions related to Osteitis Fibrosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040359.0ALPPL2, ALPP, ALPL

Products for genes affiliated with Osteitis Fibrosa

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteitis Fibrosa

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet