MCID: OST004
MIFTS: 41

Osteitis Fibrosa malady

Categories: Bone diseases

Aliases & Classifications for Osteitis Fibrosa

Aliases & Descriptions for Osteitis Fibrosa:

Name: Osteitis Fibrosa 12 52 14
Osteitis Fibrosa Cystica 42 69
Osteitis Fibrosa Cystica Generalisata 12
Von Recklinghausen's Bone Disease 12
Hyperparathyroid Bone Disease 12
Osteitis Fibrosa Disseminata 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3341
MeSH 42 D010002
NCIt 47 C34875
UMLS 69 C0029405

Summaries for Osteitis Fibrosa

Disease Ontology : 12 A bone resorption disease that has material basis in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located in bone.

MalaCards based summary : Osteitis Fibrosa, also known as osteitis fibrosa cystica, is related to pseudohypoparathyroidism, type ib and renal osteodystrophy. An important gene associated with Osteitis Fibrosa is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Presynaptic function of Kainate receptors. The drugs Etidronic acid and Risedronate Sodium have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and t cells.

Related Diseases for Osteitis Fibrosa

Diseases related to Osteitis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 pseudohypoparathyroidism, type ib 31.6 GNAS PTH
2 renal osteodystrophy 11.4
3 mccune-albright syndrome, somatic, mosaic 11.3
4 monostotic fibrous dysplasia 11.1
5 hyperparathyroidism 10.6
6 adenoma 10.4
7 parathyroid adenoma 10.4
8 osteomalacia 10.2
9 maroteaux stanescu cousin syndrome 10.2 BGLAP CALCA
10 endemic goiter 10.2 BGLAP CALCA
11 phacolytic glaucoma 10.2 BGLAP CALCA
12 immunodeficiency by defective expression of hla class 1 10.2 CALCA IL6
13 hypochondrogenesis 10.2 BGLAP PTH
14 toxicodendron dermatitis 10.2 BGLAP PTH
15 y chromosome detection 10.2 BGLAP PTH
16 acute cor pulmonale 10.2 CALCA IL6
17 stickler syndrome 10.2 CALCA PTH
18 pseudohypoparathyroidism 10.2
19 atrial heart septal defect 10.1 CALCA PTH
20 prediabetes syndrome 10.1 BGLAP PTH
21 nodular prostate 10.1 CALCA IL6
22 salpingo-oophoritis 10.1 BGLAP CALCA
23 toenail dystrophy, isolated 10.1 CALCA PTH
24 ovarian endometrioid cystadenoma 10.1 CALCA PTH
25 chromosomal disease 10.1 BGLAP PTH
26 central nervous system lymphoma 10.1 CALCA IL6
27 central hypoventilation syndrome, congenital 10.1 CALCA PTH
28 deafness, autosomal recessive 42 10.1 CALCA CASR
29 giant cell tumor 10.1
30 thyroiditis 10.1
31 striatonigral degeneration 10.1 CASR PTH
32 familial chronic myelocytic leukemia-like syndrome 10.1 CASR PTH
33 opportunistic bacterial infectious disease 10.1 BGLAP PTH
34 pancreas adenocarcinoma 10.0 BGLAP PTH
35 central nervous system leiomyoma 10.0 BGLAP IL6
36 high-grade dysplasia in patients with barrett esophagus 10.0 BGLAP CASR
37 adult ependymoblastoma 10.0 BGLAP CALCA PTH
38 acth-independent macronodular adrenal hyperplasia 10.0 BGLAP GNAS
39 hypophosphatasia, adult 10.0 BGLAP CALCA PTH
40 acrorenal syndrome 10.0 BGLAP CALCA PTH
41 ovarian insufficiency due to fsh resistance 10.0 BGLAP GNAS
42 cowper gland carcinoma 10.0 CASR PTH
43 ischemic bone disease 10.0 BGLAP CALCA PTH
44 solitary bone cyst 10.0
45 rickets 10.0
46 exanthema subitum 10.0 CALCA GNAS
47 aflatoxins-related hepatocellular carcinoma 10.0 CALCA PTH
48 pseudohypoparathyroidism ic 10.0 GNAS PTH
49 preretinal fibrosis 9.9 BGLAP CALCA
50 esophageal leukoplakia 9.9 GNAS PTH

Graphical network of the top 20 diseases related to Osteitis Fibrosa:



Diseases related to Osteitis Fibrosa

Symptoms & Phenotypes for Osteitis Fibrosa

Drugs & Therapeutics for Osteitis Fibrosa

Drugs for Osteitis Fibrosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
2 Risedronate Sodium Phase 2, Phase 3 115436-72-1
3 calcium channel blockers Phase 2, Phase 3
4 Diphosphonates Phase 2, Phase 3
5 Bone Density Conservation Agents Phase 2, Phase 3
6 Calcium, Dietary Phase 2, Phase 3
7 Hormone Antagonists Phase 3,Phase 2,Phase 1
8 Hormones Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
10
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
11
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
12
Testolactone Approved Phase 2 968-93-4 13769
13
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
14 Steroid Synthesis Inhibitors Phase 2,Phase 1
15 Estrogen Antagonists Phase 2,Phase 1
16 Estrogens Phase 2,Phase 1
17 Aromatase Inhibitors Phase 2,Phase 1
18 Antineoplastic Agents, Hormonal Phase 2
19 Estrogen Receptor Antagonists Phase 2
20
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
21
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
22
Histamine Phosphate 51-74-1 65513
23 Neurotransmitter Agents

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3
3 TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE Unknown status NCT01791842 Phase 2
4 Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001728 Phase 2
5 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2
6 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2
7 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Recruiting NCT02743377 Phase 1, Phase 2
8 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2
9 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1
10 Histamine Responsiveness in McCune-Albright Syndrome Unknown status NCT00318097
11 Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome Completed NCT00001973
12 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
13 Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
14 Natural History of Cherubism Observational Study Completed NCT01916772
15 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Recruiting NCT02868645
16 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
17 Genetic and Functional Analysis of Cherubism Recruiting NCT01630447

Search NIH Clinical Center for Osteitis Fibrosa

Cochrane evidence based reviews: osteitis fibrosa cystica

Genetic Tests for Osteitis Fibrosa

Anatomical Context for Osteitis Fibrosa

MalaCards organs/tissues related to Osteitis Fibrosa:

39
Bone, Thyroid, T Cells, Kidney, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Osteitis Fibrosa:

18
Bone

Publications for Osteitis Fibrosa

Articles related to Osteitis Fibrosa:

(show top 50) (show all 149)
id Title Authors Year
1
Osteitis fibrosa cystica. ( 27238197 )
2016
2
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
3
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. ( 27030464 )
2016
4
Brown tumors: severe osteitis fibrosa cystica. ( 25939949 )
2015
5
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. ( 25828738 )
2015
6
Osteitis fibrosa cystica in primary hyperparathyroidism. ( 26261355 )
2015
7
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. ( 25511968 )
2015
8
Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica. ( 23858315 )
2013
9
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. ( 23365170 )
2013
10
Osteitis fibrosa cystica mistaken for malignant disease. ( 23799171 )
2013
11
Successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. ( 23259108 )
2012
12
Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica. ( 21584419 )
2011
13
A rare case of primary hyperparathyroidism and osteitis fibrosa cystica. ( 20919975 )
2010
14
Visual vignette. Osteitis fibrosa cystica. ( 18753115 )
2008
15
Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. ( 18635661 )
2008
16
Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. ( 18702368 )
2008
17
Osteitis fibrosa cystica and secondary hyperparathyroidism in multiple myeloma. ( 17062009 )
2007
18
Oxyphilic cell adenoma of parathyroid resulting in primary hyperparathyroidism and osteitis fibrosa cystica--a case report. ( 17001919 )
2006
19
Osteitis fibrosa cystica, coeliac disease and Turner syndrome. A case report. ( 15285529 )
2004
20
Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. ( 15168133 )
2004
21
Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. ( 12490858 )
2002
22
Radiology quiz case 2: metastatic calcifications of the middle and external ear and osteitis fibrosa of the temporal bones as a result of secondary hyperparathyroidism. ( 11926927 )
2002
23
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. ( 11743611 )
2002
24
False positive 99mTc sestamibi scans in patients with osteitis fibrosa cystica and brown tumours. ( 11716445 )
2001
25
Effect of parathyroid adenoma resection on bone density in primary hyperparathyroidism and osteitis fibrosa cystica. ( 11688767 )
2001
26
Tc99m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. ( 11701666 )
2001
27
Images in haematology. Osteitis fibrosa cystica generalisata with adult T-cell leukaemia: a case report. ( 11054056 )
2000
28
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. ( 10594779 )
1999
29
Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report. ( 10606900 )
1999
30
Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9506717 )
1998
31
Osteitis fibrosa: treatment trends. ( 9543904 )
1998
32
Comment on marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica. ( 9768702 )
1998
33
NPS R-568 halts or reverses osteitis fibrosa in uremic rats. ( 9461105 )
1998
34
Osteitis fibrosa cystica with renal parathyroid hormone resistance: a review of pseudohypoparathyroidism with insight into calcium homeostasis. ( 9637471 )
1998
35
Osteitis fibrosa cystica and chronic renal failure. ( 9158318 )
1997
36
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism. ( 9015472 )
1996
37
Intravenous calcitriol can increase bone mass in hemodialysis patients with osteitis fibrosa. ( 7565429 )
1995
38
Pseudohypoparathyroidism with osteitis fibrosa cystica: direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. ( 8427051 )
1993
39
Paraplegia due to osteitis fibrosa secondary to primary hyperparathyroidism: report of a case. ( 8292854 )
1993
40
Case management of the anemic patient: epoetin alfa--focus on osteitis fibrosa. ( 8285805 )
1993
41
Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. ( 8249919 )
1993
42
Inhibition of 1,25(OH)2D production by hypercalcemia in osteitis fibrosa cystica: influence on parathyroid hormone secretion and hungry bone disease. ( 8274876 )
1993
43
Osteitis fibrosa cystica (brown tumor) in a patient with renal transplantation. Report of a case with aspiration cytodiagnosis. ( 1636352 )
1992
44
Current advances in the therapy of secondary hyperparathyroidism and osteitis fibrosa. ( 1813787 )
1991
45
Osteitis fibrosa cystica (brown tumor) of the spine with cord compression: report of a case with needle aspiration biopsy findings. ( 2292220 )
1990
46
Concomitant osteitis fibrosa cystica and ameloblastoma of the mandible. ( 2724257 )
1989
47
Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. ( 2631697 )
1989
48
Prevention of osteitis fibrosa, aluminium bone disease and soft-tissue calcification in dialysis patients: a long-term comparison of moderate doses of oral calcium +/- Mg(OH)2 vs Al(OH)3 +/- 1 alpha OH vitamin D3. ( 2517325 )
1989
49
Marked direct suppression of primary hyperparathyroidism with osteitis fibrosa cystica by intravenous administration of 1,25-dihydroxycholecalciferol. ( 2615719 )
1989
50
Calcitriol for osteitis fibrosa. ( 2594044 )
1989

Variations for Osteitis Fibrosa

Expression for Osteitis Fibrosa

Search GEO for disease gene expression data for Osteitis Fibrosa.

Pathways for Osteitis Fibrosa

GO Terms for Osteitis Fibrosa

Cellular components related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 BGLAP CALCA GNAS IL6 PTH

Biological processes related to Osteitis Fibrosa according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.73 BGLAP CALCA IL6
2 skeletal system development GO:0001501 9.7 BGLAP GNAS PTH
3 response to organic cyclic compound GO:0014070 9.67 BGLAP CASR IL6
4 response to drug GO:0042493 9.67 BGLAP GNAS IL6 PTH
5 response to glucocorticoid GO:0051384 9.62 BGLAP IL6
6 response to mechanical stimulus GO:0009612 9.62 BGLAP IL6
7 response to calcium ion GO:0051592 9.61 CASR IL6
8 positive regulation of osteoblast differentiation GO:0045669 9.61 GNAS IL6
9 cellular calcium ion homeostasis GO:0006874 9.61 CALCA CASR PTH
10 bone development GO:0060348 9.6 BGLAP GNAS
11 response to heat GO:0009408 9.59 CALCA IL6
12 monocyte chemotaxis GO:0002548 9.58 CALCA IL6
13 activation of adenylate cyclase activity GO:0007190 9.58 CALCA GNAS
14 vasodilation GO:0042311 9.57 CALCA CASR
15 response to vitamin D GO:0033280 9.55 BGLAP PTH
16 positive regulation of ossification GO:0045778 9.54 CALCA PTH
17 cellular response to hepatocyte growth factor stimulus GO:0035729 9.51 CASR IL6
18 negative regulation of bone resorption GO:0045779 9.48 CALCA IL6
19 cellular response to vitamin D GO:0071305 9.46 BGLAP CASR
20 response to fibroblast growth factor GO:0071774 9.4 CASR PTH
21 response to nutrient levels GO:0031667 9.33 BGLAP IL6 PTH
22 response to parathyroid hormone GO:0071107 9.32 GNAS PTH
23 positive regulation of cell proliferation in bone marrow GO:0071864 9.26 IL6 PTH
24 positive regulation of cAMP biosynthetic process GO:0030819 9.13 CALCA GNAS PTH
25 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 8.8 CALCA GNAS PTH

Sources for Osteitis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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