MCID: OST012
MIFTS: 73

Osteoarthritis malady

Bone diseases category

Summaries for Osteoarthritis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoarthritis, also known as osteoarthrosis and allied disorder, is related to arthritis and rheumatoid arthritis. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs aspirin and chondroitin and the compounds chondroitin sulfate and sid 26681509 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotype limbs/digits/tail.

Disease Ontology:8 An arthritis that has material basis in worn out cartilage located in joint.

CDC:3 Osteoarthritis is a disease characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of osteoarthritis are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, and use of medications.

Wikipedia:63 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoarthritis 8 10 44 33 30
osteoarthrosis and allied disorder 8
degenerative joint disease 8
degenerative polyarthritis 60
degenerative arthritis 8
hypertrophic arthritis 8
osteoarthrosis 8


External Ids:

Disease Ontology8 DOID:8398
ICD9CM27 715.3

Related Diseases for Osteoarthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13
2rheumatoid arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13, ASPN
3osteoporosis30.7MMP13, CTSL, CTSK, COL2A1
4multiple epiphyseal dysplasia30.2COL9A1
5pseudoachondroplasia30.0COL9A1
6stickler syndrome29.9COL2A1, COL9A1
7osteochondritis dissecans29.9COL9A1
8giant cell tumor29.7CTSL, CTSK
9synovitis10.6
10obesity10.4
11psoriatic arthritis10.3
12spondylosis10.3
13arthropathy10.3
14cartilage disease10.3
15osteoporotic fracture10.2
16spinal stenosis10.2
17hypertension10.2
18reactive arthritis10.2
19spondyloarthropathy10.2
20bone fracture10.1
21gout10.1
22osteonecrosis10.1
23pseudogout10.1
24hemochromatosis10.1
25bursitis10.1
26loeys-dietz syndrome type 310.1
27osteoarthritis with mild chondrodysplasia10.1
28familial osteochondritis dissecans10.1
29ankylosing spondylitis10.1
30acromegaly10.1
31gastroduodenitis10.1
32cervicitis10.1
33osteochondrosis10.1
34spondylitis10.1
35ocular albinism10.1
36spondylolysis10.1
37kidney disease10.1
38pigmentation disease10.1
39x-linked disease10.1
40spondylolisthesis10.0
41diffuse idiopathic skeletal hyperostosis10.0
42spondyloepiphyseal dysplasia congenita10.0
43systemic lupus erythematosus10.0
44neuronitis10.0
45chondromalacia10.0
46enthesopathy10.0
47hyperostosis10.0
48lipoma10.0
49lupus erythematosus10.0
50stickler syndrome type 110.0

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Clinical Features for Osteoarthritis

About this section

Drugs & Therapeutics for Osteoarthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoarthritis

Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Search CenterWatch for Osteoarthritis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

About this section

Anatomical Context for Osteoarthritis

About this section
Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteoarthritis:

32
Bone, Testes, Skin, Bone marrow, T cells, Endothelial, Adipocyte, Skeletal muscle, Heart, Whole blood, Brain, B cells, Placenta, Prostate

FMA organs/tissues related to Osteoarthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Osteoarthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537111.2MMP13, FRZB, CTSK, COL9A1, COL2A1

Publications for Osteoarthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Osteoarthritis:

(show top 50)    (show all 1779)
idTitleAuthorsYear
1
Age and obesity alter the relationship between femoral articular cartilage thickness and ambulatory loads in individuals without osteoarthritis. (24281940)
2014
2
Correction of acquired glenoid bone loss in osteoarthritis with a standard versus an augmented glenoid component. (24406121)
2014
3
A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis. (24168077)
2013
4
Trapeziectomy and ligament reconstruction tendon interposition for isolated scaphotrapeziotrapezoid osteoarthritis of the wrist. (24334602)
2013
5
Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis. (24119476)
2013
6
Arthritis self-efficacy scale scores in knee osteoarthritis: a systematic review and meta-analysis comparing arthritis self-management education with or without exercise. (24175602)
2013
7
Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis. (24315792)
2013
8
Evaluation of a minimally aggressive method of patellofemoral osteoarthritis treatment at 10 years minimum follow-up. (24035248)
2013
9
Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker--longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative. (24020939)
2013
10
Prevalence of carpal tunnel syndrome and wrist osteoarthritis in long-term paraplegic patients compared with controls. (23435490)
2013
11
Sirt1 and osteoarthritis. Comments on the paper by Gabay et al.: "Sirt1-deficient mice exhibit an altered cartilage phenotype", Joint Bone Spine 2013. (24321436)
2013
12
Ultrasound-guided Intraarticular Hip Injection for Osteoarthritis Pain in the Emergency Department. (24106550)
2013
13
Eccentric rotational acetabular osteotomy for osteoarthritis of the hip due to hereditary multiple exostosis: report of two cases. (23475225)
2013
14
Outcome of unicompartmental knee arthroplasty in octogenarians with tricompartmental osteoarthritis: A longer followup of previously published report. (24133305)
2013
15
"Let's Talk about OA Pain": A Qualitative Analysis of the Perceptions of People Suffering from OA. Towards the Development of a Specific Pain OA-Related Questionnaire, the Osteoarthritis Symptom Inventory Scale (OASIS). (24244589)
2013
16
A complex assessment of patients with knee osteoarthritis and Baker's cyst: observational study. (24068409)
2013
17
Lower expression of histamine Ha88 receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis. (21881994)
2012
18
Lower osteocalcin and osteopontin contents of the femoral head in hip fracture patients than osteoarthritis patients. (20625700)
2011
19
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
20
Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip--an emerging genetic overlap. (21542882)
2011
21
The role of promoter CpG islands methylation of leptin gene in osteoarthritis]. (21418891)
2011
22
Prediction model for knee osteoarthritis based on genetic and clinical information. (20939878)
2010
23
Osteoarthritis: can anti-cytokine therapy play a role in treatment? (20108016)
2010
24
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. (19942354)
2010
25
The role of synovitis in osteoarthritis. (22870460)
2010
26
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. (19902332)
2010
27
Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. (19327154)
2009
28
Expression of interleukin-1beta and tumor necrosis factor-alpha in the synovium and synovial fluid of patients with Kashin-Beck disease and osteoarthritis]. (19218098)
2009
29
The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. (19877065)
2009
30
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. (19274754)
2009
31
Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes]. (18683686)
2008
32
Interleukin-1beta gene polymorphism associated with radiographic signs of osteoarthritis of the knee. (18392912)
2008
33
Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. (18802112)
2008
34
Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population. (17763208)
2007
35
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
36
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (15708897)
2005
37
The use of opioids in the treatment of osteoarthritis: when, why, and how? (16282039)
2005
38
Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (15082485)
2004
39
Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis. (15541045)
2004
40
Benefit-risk assessment of rofecoxib in the treatment of osteoarthritis. (14756580)
2004
41
Topical lidocaine patch 5% may target a novel underlying pain mechanism in osteoarthritis. (15383194)
2004
42
Evidence for a key role of leptin in osteoarthritis. (14613274)
2003
43
Mutations in the X-linked spondyloepiphyseal dysplasia tarda (SEDL) coding sequence are not a common cause of early primary osteoarthritis in men. (12123495)
2002
44
ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. (11511685)
2001
45
Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. (10867027)
2000
46
Linkage analysis of chromosome 2q in osteoarthritis. (10817769)
2000
47
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. (9870873)
1998
48
Differential expression of IL-1 and TNF receptors in inflammatory arthritis and osteoarthritis. (8868110)
1996
49
The association between osteoarthritis and osteoporotic fracture: the Chingford Study. (9010060)
1996
50
Importance of interleukin-I receptors in osteoarthritis]. (7858606)
1994

Genetic Variations for Osteoarthritis

About this section

Expression for genes affiliated with Osteoarthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

About this section
Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Osteoarthritis

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1chondroitin sulfate44 2412.3MMP13, CTSL, CTSK, TNFAIP6
2sid 266815095911.2CTSL, CTSK, CTSA
3n-acetyl-l-leucyl-l-leucyl-l-methional5911.2CTSK, CTSA, CTSL
4l 0062355911.2CTSK, CTSA, CTSL
5e 64d44 5912.1CTSK, CTSA, CTSL
6calpeptin44 5912.1CTSK, CTSA, CTSL
7hydroxyproline44 11 2413.1MMP13, CTSL, COL2A1
8aprotinin44 1111.9CTSK, CTSL, MMP13
9rhodamine4410.9CTSL, CTSK
10actinidin4410.8CTSL, CTSK
11thermolysin4410.8MMP13, CTSL
12scca14410.7CTSL, CTSK
13glycosaminoglycan4410.6MMP13, TNFAIP6, COL2A1

GO Terms for genes affiliated with Osteoarthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.8CTSL, CTSK

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057411.2MMP13, CTSL, CTSK, COL9A1, COL2A1
2extracellular matrix disassemblyGO:02261711.1COL2A1, COL9A1, CTSK, CTSL, MMP13
3extracellular matrix organizationGO:03019810.9MMP13, CTSL, CTSK, COL9A1, COL2A1
4tissue homeostasisGO:00189410.8COL9A1, COL2A1

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:03002010.8COL9A1, COL2A1

Products for genes affiliated with Osteoarthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoarthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet