MCID: OST012
MIFTS: 83

Osteoarthritis malady

Categories: Bone diseases, Genetic diseases

Aliases & Classifications for Osteoarthritis

Aliases & Descriptions for Osteoarthritis:

Name: Osteoarthritis 38 12 29 52 41 3 14
Degenerative Joint Disease 12 29
Osteoarthrosis 12 14
Osteoarthrosis and Allied Disorder 12
Degenerative Polyarthritis 69
Degenerative Arthritis 12
Hypertrophic Arthritis 12
Arthropathy 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 35 715.3
UMLS 69 C0157946

Summaries for Osteoarthritis

MedlinePlus : 41 osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Osteoarthritis, also known as degenerative joint disease, is related to rheumatoid arthritis and osteopetrosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. The drugs Spironolactone and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. It is sometimes called degenerative joint disease or "wear and tear" arthritis. It most frequently occurs in the hands, hips, and knees. With OA, the cartilage and bones within a joint begin to break down. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling, and can result in disability. 

Wikipedia : 71 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Related Diseases for Osteoarthritis

Diseases in the Osteoarthritis family:

Osteoarthritis-5 Osteoarthritis 1

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 31.8 COMP IL1B MMP1 MMP13 MMP3 PTGS2
2 osteopetrosis 29.7 ACAN COL9A1 COMP MMP13
3 histiocytosis 29.6 IL1B MMP1 MMP3 TNF
4 osteonecrosis 28.6 ACAN ADAMTS4 ADAMTS5 ASPN BMP5 CILP
5 osteoarthritis 1 12.1
6 osteoarthritis with mild chondrodysplasia 12.1
7 osteochondritis dissecans, short stature, and early-onset osteoarthritis 12.1
8 chondrocalcinosis with early-onset osteoarthritis 11.8
9 short stature-advanced bone age-early-onset osteoarthritis syndrome 11.7
10 familial osteochondritis dissecans 11.6
11 loeys-dietz syndrome 3 11.6
12 osteoarthritis-5 11.5
13 czech dysplasia 11.4
14 arthritis 11.2
15 obesity 11.0
16 spondylosis 11.0
17 hip dysplasia, beukes type 11.0
18 cartilage disease 11.0
19 spondyloepiphyseal dysplasia tarda 11.0
20 ehlers-danlos syndrome 11.0
21 occipital neuralgia 11.0
22 alkaptonuria 11.0
23 ochronosis 11.0
24 psoriasis 11.0
25 spondyloepiphyseal dysplasia, stanescu type 10.9
26 epiphyseal dysplasia, multiple, 1 10.8
27 legg-calve-perthes disease 10.8
28 developmental dysplasia of the hip 1 10.8
29 spondyloepimetaphyseal dysplasia with joint laxity, type 2 10.8
30 pseudoachondroplasia 10.8
31 diastrophic dysplasia 10.8
32 digital arthropathy-brachydactyly, familial 10.8
33 loeys-dietz syndrome 1 10.6
34 epiphyseal dysplasia, multiple, 5 10.6
35 spondyloepiphyseal dysplasia tarda, autosomal dominant 10.6
36 stickler syndrome, type i 10.6
37 desbuquois dysplasia 1 10.6
38 central cord syndrome 10.6
39 developmental dysplasia of the hip 2 10.6
40 stickler sydrome, type i, nonsyndromic ocular 10.6
41 spondylometaphyseal dysplasia, kozlowski type 10.6
42 cerebral palsy 10.4 ACAN COL2A1 COMP
43 epiphyseal dysplasia, multiple, with myopia and deafness 10.4 ACAN COL2A1 COMP
44 intussusception 10.4 IL1B TNF
45 sp7-related osteogenesis imperfecta 10.4 ACAN COL2A1 COMP
46 smed strudwick type 10.4 ASPN COL2A1 COMP
47 vulvar sarcoma 10.4 ACAN COMP TGFB1
48 systemic scleroderma 10.4 GDF5 MMP3 PTGS2
49 symmastia 10.4 MMP1 MMP3
50 chondrodysplasia punctata, rhizomelic, type 1 10.4 IL1B MMP3 PTGS2

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Disorder Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Dysthymic Disorder Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Ischemic Heart Disease
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis

Symptoms & Phenotypes for Osteoarthritis

UMLS symptoms related to Osteoarthritis:


arthralgia, back pain, metatarsalgia, muscle cramp, sciatica, joint swelling, other symptoms referable to joint, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, joint stiffness, musculoskeletal symptom, other symptoms referable to joint, site unspecified, joint symptom, stiffness of joint, not elsewhere classified in icd10cm, angina pectoris, tremor, equilibration disorder

MGI Mouse Phenotypes related to Osteoarthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 COMP DDR2 FRZB IL1B MMP1 MMP13
2 immune system MP:0005387 10.03 ADAMTS5 BMP5 COL2A1 COL9A1 COMP IL1B
3 integument MP:0010771 9.76 ADAMTS5 DDR2 FRZB IL1B MMP13 PTGS2
4 limbs/digits/tail MP:0005371 9.7 COMP DDR2 FRZB GDF5 MMP13 TNF
5 skeleton MP:0005390 9.5 ADAMTS4 ADAMTS5 BMP5 COL2A1 COL9A1 COMP

Drugs & Therapeutics for Osteoarthritis

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 624)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 9004-61-9 53477741 24759
3
Milnacipran Approved Phase 4 92623-85-3 65833
4
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2 51-41-2 439260
5
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
6
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 1302 156391
7
Nabumetone Approved Phase 4 42924-53-8 4409
8
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 1197-18-8 5526
9
Denosumab Approved Phase 4,Phase 2 615258-40-7
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
11
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 71273 175805
12
Hyoscyamine Approved Phase 4 101-31-5 64692
13
Cimetidine Approved Phase 4,Phase 3,Phase 2 51481-61-9 2756
14
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
15
Tranylcypromine Approved Phase 4 155-09-9 441233
16
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
17
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
18
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
19
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
20
Methyclothiazide Approved Phase 4 135-07-9 4121
21
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
22
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
23
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
24
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
25
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
26
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
27
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
28
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
29
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
30
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
31
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 5281106 54677470
32
Benzocaine Approved Phase 4,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
33 Parecoxib Approved Phase 4,Phase 3 198470-84-7
34
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
35
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
36
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
37
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
39
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 51-61-6, 62-31-7 681
40
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
41
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2 76-57-3 5284371
42
Infliximab Approved Phase 4 170277-31-3
43
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 52485-79-7 40400 644073
44
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 27203-92-5 33741
45
Lumiracoxib Approved, Investigational Phase 4,Phase 3 220991-20-8 151166
46
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 9552079 2713
47
chloroquine Approved, Vet_approved Phase 4 54-05-7 2719
48
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 202409-33-4 123619
49
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2 465-65-6 5284596
50
Aceclofenac Approved Phase 4 89796-99-6

Interventional clinical trials:

(show top 50) (show all 3068)
id Name Status NCT ID Phase
1 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4
2 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4
3 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4
4 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4
5 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4
6 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4
7 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4
8 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4
9 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
10 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4
11 To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee Unknown status NCT02049606 Phase 4
12 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4
13 A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
14 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4
15 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
16 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
17 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
18 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4
19 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
20 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4
21 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4
22 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
23 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
24 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
25 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4
26 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
27 Artelon Metatarsophalangeal (MTP) Spacer Unknown status NCT01028469 Phase 4
28 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4
29 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
30 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
31 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
32 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4
33 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
34 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
35 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4
36 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4
37 Corticosteroids as Additive in Temporomandibular Joint (TMJ) Arthrocentesis Unknown status NCT01275014 Phase 4
38 Comparison Between Anterior and Direct Lateral Approach in Total Hip Arthroplasty Unknown status NCT01578746 Phase 4
39 Bipolar Sealer Aquamantys Use in Total Knee Replacement Unknown status NCT01736644 Phase 4
40 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4
41 Divalproex Sodium ER in Adult Autism Unknown status NCT00211796 Phase 4
42 A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Unknown status NCT00208442 Phase 4
43 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4
44 NSAID Treatment in Knee Osteoarthritis Completed NCT01860833 Phase 4
45 Effect of Diacerein on Hand Osteoarthritis Completed NCT00685542 Phase 4
46 The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis Completed NCT01383954 Phase 4
47 Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain Completed NCT01742897 Phase 4
48 Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee Completed NCT01066676 Phase 4
49 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Participants With Osteoarthritis Completed NCT01774929 Phase 4
50 Patterned Electrical Neuromuscular Stimulation and Therapeutic Exercise for Osteoarthritis of the Knee: Pilot Study Completed NCT00701506 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
AlloStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel PMIDs: 17515233 17590152 16510814
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 10102814 14673997 19530993 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity PMIDs: 21056860 20508015

Genetic Tests for Osteoarthritis

Genetic tests related to Osteoarthritis:

id Genetic test Affiliating Genes
1 Osteoarthritis 29
2 Degenerative Joint Disease 29

Anatomical Context for Osteoarthritis

MalaCards organs/tissues related to Osteoarthritis:

39
Bone, Testes, Skin, Bone Marrow, T Cells, Endothelial, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

18
Joint
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id Tissue Anatomical CompartmentCell Relevance
1 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
2 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
3 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
4 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
5 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
6 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
7 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
8 Cartilage Temporomandibular Joint Affected by disease
9 Bone Vertebrae Affected by disease

Publications for Osteoarthritis

Articles related to Osteoarthritis:

(show top 50) (show all 2243)
id Title Authors Year
1
Upregulation of microRNA-125b-5p is involved in the pathogenesis of osteoarthritis by downregulating SYVN1. ( 28260078 )
2017
2
Reduced miRa8926a and miRa8926b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation. ( 28000846 )
2017
3
An underlying diagnosis of osteonecrosis of bone is associated with worse outcomes than osteoarthritis after total hip arthroplasty. ( 28068972 )
2017
4
Evaluation of validity and reliability of the Persian version of the functional index of hand osteoarthritis. ( 28084532 )
2017
5
Ankylosis of the Finger in Erosive Osteoarthritis. ( 28090062 )
2017
6
Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). ( 28082368 )
2017
7
Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regeneration. ( 28083966 )
2017
8
Does inflammation predict radiographic progression in hand osteoarthritis? ( 28087504 )
2017
9
Additional Evidence Supports Association of Common Variants in COL11A1 with Increased Risk of Hip Osteoarthritis Susceptibility. ( 27936936 )
2017
10
Characterization of the Walch B3 glenoid in primary osteoarthritis. ( 28089255 )
2017
11
Response to 'Does inflammation predict radiographic progression in hand osteoarthritis?' by Li et al. ( 28087507 )
2017
12
Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the Osteoarthritis Initiative. ( 28084653 )
2017
13
MODERATE-INTENSITY RESISTANCE EXERCISE ALTERS SKELETAL MUSCLE MOLECULAR AND CELLULAR STRUCTURE AND FUNCTION IN INACTIVE, OLDER ADULTS WITH KNEE OSTEOARTHRITIS. ( 28082334 )
2017
14
A longitudinal comparative study of falls in persons with knee arthroplasty and persons with or at high risk for knee osteoarthritis. ( 28087557 )
2017
15
Validity and Responsiveness of the Knee injury and Osteoarthritis Outcome Score (KOOS): A Comparative Study among Total Knee Replacement Patients. ( 28085998 )
2017
16
The rs4238326 polymorphism in ALDH1A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study. ( 28089900 )
2017
17
TAR DNA-binding protein 43 inhibits inflammatory response and protects chondrocyte function by modulating RACK1 expression in osteoarthritis. ( 27890430 )
2017
18
Strontium ranelate, a promising disease modifying osteoarthritis drug. ( 28092725 )
2017
19
Synovial fluid concentrations of cold-inducible RNA-binding protein are associated with severity in knee osteoarthritis. ( 27840101 )
2017
20
Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. ( 28087412 )
2017
21
TUFT1, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway. ( 28410428 )
2017
22
Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis. ( 27922673 )
2017
23
Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis. ( 28526072 )
2017
24
Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model. ( 28091618 )
2017
25
A dual role for UCMA in osteoarthritis-Inhibition of aggrecanases and promotion of bone turnover. ( 28086000 )
2017
26
Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia. ( 28520086 )
2017
27
Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis. ( 28087567 )
2017
28
Increased frequency of peripheral blood follicular helper T cells and elevated serum ILa8921 levels in patients with knee osteoarthritis. ( 28112376 )
2017
29
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis. ( 25180294 )
2016
30
Osteoarthritis: Yet another death knell for paracetamol in OA. ( 27215205 )
2016
31
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. ( 27367673 )
2016
32
Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a. ( 27529373 )
2016
33
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016): Committee of National Societies Abstracts. ( 27188179 )
2016
34
I+-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients. ( 27396757 )
2016
35
DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. ( 26751999 )
2016
36
VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. ( 26818776 )
2016
37
Impact of non-steroidal anti-inflammatory drugs on cardiovascular risk: Is it the same in osteoarthritis and rheumatoid arthritis? ( 27659504 )
2016
38
Association between circulating adipokines, radiographic changes, and knee cartilage volume in patients with knee osteoarthritis. ( 26505548 )
2016
39
Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood. ( 27214559 )
2016
40
Associations between clinical evidence of inflammation and synovitis in symptomatic knee osteoarthritis: A substudy of the VIDEO trial. ( 27998036 )
2016
41
Expression and Significance of High-Mobility Group Protein B1 (HMGB1) and the Receptor for Advanced Glycation End-Product (RAGE) in Knee Osteoarthritis. ( 27320800 )
2016
42
Treatment of Depression in patients with Osteoarthritis: the importance of an early diagnosis and the role of Duloxetine. ( 27663827 )
2016
43
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. ( 27660691 )
2016
44
Novel effects of sarcopenic osteoarthritis on metabolic syndrome, insulin resistance, osteoporosis, and bone fracture: the national survey. ( 27177746 )
2016
45
Cross-sectional association between muscle strength and self-reported physical function in 195 hip osteoarthritis patients. ( 27665019 )
2016
46
Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis. ( 26934480 )
2016
47
Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. ( 26972586 )
2016
48
Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3I+ in osteoarthritis. ( 26861791 )
2016
49
Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative. ( 27704199 )
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Single Nucleotide Polymorphisms and Osteoarthritis: An Overview and a Meta-Analysis. ( 26886631 )
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