MCID: OST012
MIFTS: 80

Osteoarthritis malady

Genetic diseases (common), Bone diseases categories

Aliases & Classifications for Osteoarthritis

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Osteoarthritis, Aliases & Descriptions:

Name: Osteoarthritis 30 9 11 43 32 3
Osteoarthrosis and Allied Disorder 9
Degenerative Joint Disease 9
Degenerative Polyarthritis 60
 
Hypertrophic Arthritis 9
Degenerative Arthritis 9
Osteoarthrosis 9
Arthropathy 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:8398
ICD9CM27 715.3

Summaries for Osteoarthritis

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MedlinePlus:32 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Osteoarthritis, also known as osteoarthrosis and allied disorder, is related to arthritis and rheumatoid arthritis, and has symptoms including autosomal dominant inheritance, autosomal recessive inheritance and heterogeneous. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Matrix Metalloproteinases. The drugs aspirin and diclofenac and the compounds actinidin and rhodamine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and pancreas, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:9 An arthritis that has material basis in worn out cartilage located in joint.

CDC:3 Osteoarthritis (OA) is a disease of the entire joint involving the cartilage, joint lining, ligaments, and underlying bone. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of OA are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, use of medications, and eventually total joint replacement.

Wikipedia:63 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Related Diseases for Osteoarthritis

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Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.8TNFAIP6, MMP13, COL2A1, CTSK, CTSL
2rheumatoid arthritis31.6TNFAIP6, MMP13, ASPN, COL2A1, CTSK, CTSL
3osteoporosis31.2MMP13, COL2A1, CTSK, CTSL
4stickler syndrome30.8COL9A1, COL2A1
5osteochondritis dissecans30.6COL9A1
6osteoarthritis-530.5COL2A1, ASPN, FRZB
7multiple epiphyseal dysplasia30.4COL9A1
8atherosclerosis30.2CTSL, CTSK, MMP13
9giant cell tumor30.0CTSK, CTSL
10synovitis10.6
11blindness10.6
12obesity10.4
13psoriatic arthritis10.4
14spondylosis10.3
15skeletal dysplasia multi-gene panels10.3CTSK, COL2A1, MMP13
16osteoarthritis with mild chondrodysplasia10.3
17arthropathy10.3
18bone cancer10.3MMP13, CTSL
19chondrodysplasia10.3
20insulin-like growth factor i10.3
21chondrocalcinosis with early-onset osteoarthritis10.3
22kashin-beck disease10.3
23spinal stenosis10.3
24bursitis10.3
25abdominal aortic aneurysm10.3CTSL, MMP13
26hemophilia a10.2
27osteochondritis dissecans, short stature, and early-onset osteoarthritis10.2
28loeys-dietz syndrome, type 310.2
29acromegaly10.2
30spondyloarthropathy10.2
31hypoxia10.2
32pseudoachondroplasia10.2
33hemochromatosis10.2
34spondyloepiphyseal dysplasia tarda10.2
35osteonecrosis10.2
36reactive arthritis10.2
37gout10.2
38spondylitis10.2
39synovial chondromatosis10.2
40aneurysm10.2
41back pain10.2
42chronic pain10.2
43osteoporotic fracture10.2
44endotheliitis10.2
45epiphyseal dysplasia, multiple, 410.1
46osteochondrosis10.1
47septic arthritis10.1
48gastroduodenitis10.1
49cervicitis10.1
50enthesopathy10.1

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Symptoms for Osteoarthritis

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HPO human phenotypes related to Osteoarthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 heterogeneous HP:0001425
4 multifactorial inheritance HP:0001426
5 abnormality of pelvic girdle bone morphology HP:0002644
6 hip osteoarthritis HP:0008843

Drugs & Therapeutics for Osteoarthritis

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Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

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Anatomical Context for Osteoarthritis

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MalaCards organs/tissues related to Osteoarthritis:

31
Bone, Pancreas, Testes, Skin, T cells, B cells, Bone marrow, Endothelial, Brain, Placenta, Eye, Spleen, Cortex, Retina, Smooth muscle, Adipocyte, Myeloid, Heart, Skeletal muscle, Neutrophil, Whole blood, Prostate

FMA organs/tissues related to Osteoarthritis:

14
Joint

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

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MGI Mouse Phenotypes related to Osteoarthritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.4FRZB, MMP13, COL2A1, COL9A1, CTSK, CTSL
2MP:00053719.4FRZB, MMP13, COL2A1, COL9A1, CTSK

Publications for Osteoarthritis

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Articles related to Osteoarthritis:

(show top 50)    (show all 1850)
idTitleAuthorsYear
1
Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis. (25383958)
2014
2
Topical Ginger Treatment With a Compress or Patch for Osteoarthritis Symptoms. (24305660)
2014
3
Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. (25389358)
2014
4
Ten-year long-term results of total joint arthroplasties with ARPE(R) implant in the treatment of trapeziometacarpal osteoarthritis. (24334554)
2013
5
Evaluation of the degree of knee joint osteoarthritis in patients with early gray hair. (24403769)
2013
6
Quadriceps rate of force development affects gait and function in people with knee osteoarthritis. (24240535)
2013
7
Effects of cognitive task demands on subsequent symptoms and activity in adults with symptomatic osteoarthritis. (24195902)
2013
8
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
9
Gout and osteoarthritis: a pathogenetic link? (22867976)
2012
10
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis. (22284607)
2012
11
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
12
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. (22340319)
2011
13
Alterations in expression of cartilage-specific genes for aggrecan and collagen type II in osteoarthritis. (21655647)
2011
14
Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. (21199727)
2010
15
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. (20506137)
2010
16
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (20495570)
2010
17
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. (19054821)
2009
18
Expression of MicroRNA-146a in osteoarthritis cartilage. (19333945)
2009
19
Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (19802674)
2009
20
The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. (17676627)
2008
21
Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. (18438860)
2008
22
Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes]. (18683686)
2008
23
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (18240210)
2008
24
Effects of activity strategy training on pain and physical activity in older adults with knee or hip osteoarthritis: a pilot study. (18821646)
2008
25
Osteoarthritis and obesity: experimental models. (19022697)
2008
26
Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients. (18695981)
2008
27
Tramadol extended-release formulations in the management of pain due to osteoarthritis. (18052769)
2007
28
Expression and regulation of the osteoarthritis-associated protein asporin. (17804408)
2007
29
Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. (16889986)
2007
30
Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand. (16396979)
2006
31
Life without COX 2 inhibitors: opioids can be prescribed safely in osteoarthritis. (16777897)
2006
32
Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. (16564620)
2006
33
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
34
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
35
New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease. (15578449)
2005
36
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. (15533759)
2004
37
Comparison of the activities of multinucleated bone-resorbing giant cells derived from CD14-positive cells in the synovial fluids of rheumatoid arthritis and osteoarthritis patients. (14762224)
2004
38
Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (15082485)
2004
39
Expression of collagen type I and type II in consecutive stages of human osteoarthritis. (15316793)
2004
40
Inflammatory cell and cytokine patterns in patients with painful clicking and osteoarthritis in the temporomandibular joint. (14505622)
2003
41
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. (12801482)
2003
42
Association of two gene polymorphisms with osteoarthritis secondary to hip dysplasia. (12360016)
2002
43
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. (11203734)
2000
44
Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. (11005786)
2000
45
Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis. (10451709)
1999
46
Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. (9783757)
1998
47
The levels of collagenase, tissue inhibitor of metalloproteinases-1 (TIMP-1), collagenase approximately TIMP-1 complexes and glycosaminoglycan (GAG) in sequential samples of synovial fluid aspirated from patients with osteoarthritis. (7586773)
1995
48
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids. (8886087)
1993
49
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (1569188)
1992
50
Recurrent calcific periarthritis, erosive osteoarthritis and hypophosphatasia: a family study. (2290172)
1990

Variations for Osteoarthritis

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Expression for genes affiliated with Osteoarthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Osteoarthritis patients vs. healthy controls: 30 (show all 85)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1COL10A1collagen, type X, alpha 1Pancreas+7.520.000
2COL5A1collagen, type V, alpha 1Pancreas+7.460.000
3SULF1sulfatase 1Pancreas+7.380.000
4POSTNperiostin, osteoblast specific factorPancreas+7.240.000
5COL1A1collagen, type I, alpha 1Pancreas+7.170.000
6CEACAM5carcinoembryonic antigen-related cell adhesion molecule 5Pancreas+7.100.000
7COL11A1collagen, type XI, alpha 1Pancreas+7.000.000
8INHBAinhibin, beta APancreas+6.950.000
9CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Pancreas+6.860.000
10COL3A1collagen, type III, alpha 1Pancreas+6.780.000
11SFRP4secreted frizzled-related protein 4Pancreas+6.760.000
12COL1A2collagen, type I, alpha 2Pancreas+6.720.000
13S100PS100 calcium binding protein PPancreas+6.670.000
14CTHRC1collagen triple helix repeat containing 1Pancreas+6.600.000
15VCANversicanPancreas+6.510.000
16CTSEcathepsin EPancreas+6.300.000
17GJB2gap junction protein, beta 2, 26kDaPancreas+6.240.000
18PLAUplasminogen activator, urokinasePancreas+6.150.000
19COL5A2collagen, type V, alpha 2Pancreas+6.130.000
20CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Cartilage-6.040.000
21SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3CPancreas+6.000.000
22CXCL5chemokine (C-X-C motif) ligand 5Pancreas+5.920.000
23CLDN18claudin 18Pancreas+5.790.001
24XAF1XIAP associated factor 1Pancreas+5.720.000
25NTMneurotriminPancreas+5.710.000
26CDH11cadherin 11, type 2, OB-cadherin (osteoblast)Pancreas+5.670.000
27SAMSN1SAM domain, SH3 domain and nuclear localization signals 1Pancreas+5.660.000
28SFNstratifinPancreas+5.650.000
29MFAP5microfibrillar associated protein 5Pancreas+5.650.000
30EDNRAendothelin receptor type APancreas+5.550.000
31ASPNasporinPancreas+5.530.000
32RUNX2runt-related transcription factor 2Pancreas+5.450.000
33SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Pancreas+5.420.000
34LEF1lymphoid enhancer-binding factor 1Pancreas+5.410.000
35COL12A1collagen, type XII, alpha 1Pancreas+5.410.000
36PCDH7protocadherin 7Pancreas+5.390.000
37IFI44Linterferon-induced protein 44-likePancreas+5.380.000
38FAPfibroblast activation protein, alphaPancreas+5.380.000
39LY75lymphocyte antigen 75Pancreas+5.380.000
40PTPRCprotein tyrosine phosphatase, receptor type, CPancreas+5.360.000
41SFRP2secreted frizzled-related protein 2Pancreas+5.360.000
42GBP1guanylate binding protein 1, interferon-induciblePancreas+5.280.000
43GREM1gremlin 1, DAN family BMP antagonistPancreas+5.220.000
44THY1Thy-1 cell surface antigenPancreas+5.210.000
45VNN1vanin 1Pancreas+5.200.000
46FNDC1fibronectin type III domain containing 1Pancreas+5.170.000
47HEPHhephaestinPancreas+5.160.000
48SLC6A14solute carrier family 6 (amino acid transporter), member 14Pancreas+5.150.000
49FOSBFBJ murine osteosarcoma viral oncogene homolog BCartilage-5.130.000
50KLF5Kruppel-like factor 5 (intestinal)Pancreas+5.120.000
51TRIM29tripartite motif containing 29Pancreas+5.110.000
52SLC20A1solute carrier family 20 (phosphate transporter), member 1Pancreas+5.100.000
53PLAC8placenta-specific 8Pancreas+5.090.000
54MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FCartilage-4.560.000
55ANGPTL7angiopoietin-like 7Cartilage-4.420.000
56FAM107Afamily with sequence similarity 107, member ACartilage-4.260.000
57APODapolipoprotein DCartilage-4.050.000
58JUNjun proto-oncogeneCartilage-4.030.000
59NFIL3nuclear factor, interleukin 3 regulatedCartilage-3.800.000
60SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3Cartilage-3.760.000
61SLCO4A1solute carrier organic anion transporter family, member 4A1Cartilage-3.730.000
62GADD45Bgrowth arrest and DNA-damage-inducible, betaCartilage-3.660.000
63CXCL2chemokine (C-X-C motif) ligand 2Cartilage-3.660.000
64IL8interleukin 8Cartilage-3.560.000
65CXCL3chemokine (C-X-C motif) ligand 3Cartilage-3.550.000
66ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideCartilage-3.550.000
67FOSL2FOS-like antigen 2Cartilage-3.540.000
68VEGFAvascular endothelial growth factor ACartilage-3.540.000
69FKBP5FK506 binding protein 5Cartilage-3.520.003
70ADCY2adenylate cyclase 2 (brain)Cartilage-3.500.000
71APOLD1apolipoprotein L domain containing 1Cartilage-3.370.000
72SIK1salt-inducible kinase 1Cartilage-3.340.000
73DDIT4DNA-damage-inducible transcript 4Cartilage-3.330.000
74PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Cartilage-3.290.000
75MUC1mucin 1, cell surface associatedCartilage-3.270.000
76PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Cartilage-3.270.000
77DUSP2dual specificity phosphatase 2Cartilage-3.250.000
78SOD2superoxide dismutase 2, mitochondrialCartilage-3.200.000
79CEBPDCCAAT/enhancer binding protein (C/EBP), deltaCartilage-3.180.000
80NR4A2nuclear receptor subfamily 4, group A, member 2Cartilage-3.180.000
81ATF3activating transcription factor 3Cartilage-3.180.000
82RRADRas-related associated with diabetesCartilage-3.070.001
83KLF9Kruppel-like factor 9Cartilage-3.060.000
84MFAP5microfibrillar associated protein 5Cartilage-3.050.013
85SLC16A7solute carrier family 16 (monocarboxylate transporter), member 7Cartilage-3.010.000

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

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Compounds for genes affiliated with Osteoarthritis

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Compounds related to Osteoarthritis according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1actinidin4310.3CTSL, CTSK
2rhodamine4310.3CTSL, CTSK
3scca14310.3CTSL, CTSK
4thermolysin4310.2MMP13, CTSL
5hydroxyproline43 24 1212.2MMP13, COL2A1, CTSL
6alginate4310.2COL2A1, MMP13
7aprotinin43 1211.1MMP13, CTSK, CTSL
8glycosaminoglycan4310.1COL2A1, MMP13, TNFAIP6
9sid 266815095910.0CTSL, CTSK, CTSV, CTSA
10n-acetyl-l-leucyl-l-leucyl-l-methional5910.0CTSK, CTSV, CTSA, CTSL
11chondroitin sulfate43 2411.0CTSL, CTSK, MMP13, TNFAIP6
12l 0062355910.0CTSK, CTSV, CTSA, CTSL
13e 64d43 5911.0CTSK, CTSV, CTSA, CTSL
14calpeptin43 5911.0CTSK, CTSV, CTSA, CTSL
15aspartate439.9CTSL, CTSK, COL2A1, ASPN
16phenylalanine439.8CTSL, CTSK, MMP13
171,10-phenanthroline43 210.8CTSL, CTSK
18cysteine439.5MMP13, COL2A1, CTSK, CTSV, CTSL
19serine439.4TNFAIP6, MMP13, COL2A1, CTSK, CTSA, CTSL

GO Terms for genes affiliated with Osteoarthritis

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Cellular components related to Osteoarthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:003602110.1CTSK, CTSL
2lysosomal lumenGO:00432029.8CTSV, CTSA, CTSL
3extracellular spaceGO:00056159.6CTSL, FRZB, MMP13, CTSK, COL2A1
4extracellular regionGO:00055769.1CTSL, COL2A1, CTSV, MMP13, CTSK, COL9A1

Biological processes related to Osteoarthritis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:003028210.1MMP13, ASPN
2proteolysis involved in cellular protein catabolic processGO:005160310.1CTSL, CTSK
3tissue homeostasisGO:000189410.1COL2A1, COL9A1
4collagen catabolic processGO:00305749.7CTSK, CTSL, COL9A1, COL2A1, MMP13
5proteolysisGO:00065089.6MMP13, CTSK, CTSL
6extracellular matrix disassemblyGO:00226179.5COL2A1, MMP13, COL9A1, CTSL, CTSV, CTSK
7extracellular matrix organizationGO:00301989.5MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Molecular functions related to Osteoarthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:000196810.1CTSK, CTSL
2extracellular matrix structural constituent conferring tensile strengthGO:003002010.1COL2A1, COL9A1
3cysteine-type endopeptidase activityGO:000419710.0CTSL, CTSV, CTSK
4cysteine-type peptidase activityGO:00082349.9CTSK, CTSV, CTSL
5collagen bindingGO:00055189.9ASPN, CTSK, CTSL
6proteoglycan bindingGO:00433949.8CTSL, CTSK

Products for genes affiliated with Osteoarthritis

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Sources for Osteoarthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet