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MCID: OST012
MIFTS: 88

Osteoarthritis

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Osteoarthritis

About this section

MalaCards integrated aliases for Osteoarthritis:

Name: Osteoarthritis 37 12 72 24 28 51 40 3 14 59
Degenerative Joint Disease 12 24 28
Degenerative Polyarthritis 24 69
Hypertrophic Arthritis 12 24
Osteoarthrosis 12 24
Arthropathy 24 69
Osteoarthrosis and Allied Disorder 12
Osteoarthritis Deformans 24
Osteoarthrosis Deformans 69
Arthritis, Degenerative 24
Degenerative Arthritis 12
Kashin-Beck Disease 69
Oa 24

Characteristics:

HPO:

31
osteoarthritis:
Inheritance heterogeneous autosomal recessive inheritance autosomal dominant inheritance multifactorial inheritance


Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8398
ICD9CM 34 715.3
SNOMED-CT via HPO 65 263681008 258211005 239872002
Sources

Summaries for Osteoarthritis

About this section
MedlinePlus : 40 Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine. Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint. Risk factors for osteoarthritis include Being overweight Getting older Injuring a joint No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. Treatments include exercise, medicines, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Osteoarthritis, also known as degenerative joint disease, is related to otospondylomegaepiphyseal dysplasia, autosomal recessive and cartilage disease, and has symptoms including abnormality of pelvic girdle bone morphology, hip osteoarthritis and equilibration disorder. An important gene associated with Osteoarthritis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Spironolactone and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are immune system and limbs/digits/tail

Disease Ontology : 12 An arthritis that has material basis in worn out cartilage located in joint.

Genetics Home Reference : 24 Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.

CDC : 3 Osteoarthritis (OA) is the most common form of arthritis. It is sometimes called degenerative joint disease or “wear and tear” arthritis. It most frequently occurs in the hands, hips, and knees. With OA, the cartilage and bones within a joint begin to break down. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling, and can result in disability.

PubMed Health : 59
About osteoarthritis: Painful or stiff joints and a crunching sensation in the joints are typical signs of osteoarthritis, often also called "degenerative joint disease." Lots of people have joint problems as they get older, and some already have problems in middle age.If symptoms get worse, they can severely limit mobility. Osteoarthritis can affect every joint, but it is most common in the knee, hip or spine.

Wikipedia : 72 Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and... more...

Sources

Related Diseases for Osteoarthritis

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Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 otospondylomegaepiphyseal dysplasia, autosomal recessive 32.9 COL11A2 COL2A1
2 cartilage disease 32.6 ACAN COL2A1 COMP
3 otospondylomegaepiphyseal dysplasia, autosomal dominant 32.2 COL11A2 COL2A1
4 diastrophic dysplasia 32.2 COL2A1 COMP TGFB1
5 pseudoachondroplasia 32.1 ACAN COL9A1 COMP MATN3
6 rheumatoid arthritis 31.8 COMP IL1B MMP1 MMP13 MMP3 PTGS2
7 arthritis 31.8 ACAN ADAMTS5 COL2A1 IL1B MMP1 MMP13
8 synovitis 31.0 COMP IL1B MMP1 MMP13 MMP3
9 kashin-beck disease 30.9 IL1B MMP1
10 psoriatic arthritis 30.7 COMP IL1B MMP1 MMP3
11 spinal stenosis 30.5 ACAN COL11A2 COL2A1 COL9A1 MMP3
12 spondylolisthesis 30.5 GDF5 MMP3 PTGS2
13 stickler syndrome 30.4 COL11A2 COL2A1 COL9A1
14 back pain 30.4 ASPN CILP
15 hemophilic arthropathy 30.4 COMP PTGS2
16 degenerative disc disease 30.4 ACAN ASPN GDF5 MMP3
17 carpal tunnel syndrome 30.3 ACAN IL1B TGFB1
18 osteochondritis dissecans 30.2 ACAN COL9A1 COMP MATN3 MMP13 MMP3
19 multiple epiphyseal dysplasia 30.1 ACAN COL11A2 COL2A1 COL9A1 COMP MATN3
20 otospondylomegaepiphyseal dysplasia 30.1 COL11A2 COL2A1
21 spondyloepiphyseal dysplasia congenita 30.0 ASPN COL2A1 COMP DDR2 MMP13
22 chondrosarcoma 29.9 MMP1 MMP13 MMP3
23 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 12.5
24 osteoarthritis with mild chondrodysplasia 12.5
25 multicentric osteolysis, nodulosis, and arthropathy 12.4
26 arthropathy, progressive pseudorheumatoid, of childhood 12.4
27 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.4
28 crystal arthropathies 12.4
29 loeys-dietz syndrome 3 11.9
30 short stature-advanced bone age-early-onset osteoarthritis syndrome 11.9
31 familial osteochondritis dissecans 11.8
32 czech dysplasia 11.5
33 developmental dysplasia of the hip 1 11.3
34 spondylosis 11.2
35 chondrocalcinosis 1 11.1
36 beukes hip dysplasia 11.1
37 spondyloepiphyseal dysplasia tarda, x-linked 11.1
38 ochronosis 11.1
39 psoriasis 11.1
40 occipital neuralgia 11.1
41 brachyolmia type 3 11.0
42 spondyloepiphyseal dysplasia, stanescu type 11.0
43 epiphyseal dysplasia, multiple, 1 11.0
44 legg-calve-perthes disease 10.9
45 spondyloepimetaphyseal dysplasia with joint laxity, type 2 10.9
46 digital arthropathy-brachydactyly, familial 10.9
47 angel-shaped phalangoepiphyseal dysplasia 10.7
48 stickler syndrome, type i 10.7
49 endosteal hyperostosis, autosomal dominant 10.7
50 osteomesopyknosis 10.7

Comorbidity relations with Osteoarthritis via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Dysthymic Disorder Esophagitis
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Major Depressive Disorder
Osteoporosis Peripheral Vascular Disease
Rheumatoid Arthritis Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to Osteoarthritis
Sources

Symptoms & Phenotypes for Osteoarthritis

About this section

Human phenotypes related to Osteoarthritis:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of pelvic girdle bone morphology 31 HP:0002644
2 hip osteoarthritis 31 HP:0008843

UMLS symptoms related to Osteoarthritis:


equilibration disorder, tremor, sciatica, muscle cramp, back pain, angina pectoris, stiffness of joint, not elsewhere classified in icd10cm, joint symptom, other symptoms referable to joint, site unspecified, musculoskeletal symptom, joint stiffness, other symptoms referable to joint, multiple sites, other symptoms referable to joint, other specified sites, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, lower leg, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, hand, other symptoms referable to joint, forearm, other symptoms referable to joint, upper arm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, metatarsalgia, arthralgia

MGI Mouse Phenotypes related to Osteoarthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.93 ADAMTS5 BMP5 COL2A1 COL9A1 COMP IL1B
2 limbs/digits/tail MP:0005371 9.7 ADAMTS5 ASPN BMP5 COL2A1 COL9A1 COMP
3 skeleton MP:0005390 9.5 MATN3 MMP13 MMP3 PTGS2 TGFB1 ADAMTS5
Sources

Drugs & Therapeutics for Osteoarthritis

About this section

PubMedHealth treatment related to Osteoarthritis: 59

There are many different suggestions and recommendations for treating osteoarthritis, but so far no cure. Most treatments aim to at least slow down the development of osteoarthritis and relieve the symptoms so that daily life is affected as little as possible.There are two different types of therapies: Surgical and non-surgical. Non-surgical therapies include painkillers, exercise and weight loss, for example. Obese people with osteoarthritis of the knee or hip are often advised to lose weight. Studies indicate that weight loss can be helpful if it is combined with exercise therapy.The question of which therapies can improve mobility and relieve pain also depends on the joint that is affected. For example, therapy involving aerobics or muscle-strengthening exercises could help people with knee osteoarthritis. Other treatment options include massage, acupuncture, TENS, medicinal baths or orthopedic insoles.Surgery options for osteoarthritis of the knee include smoothing the cartilage (arthroscopy). But in many cases people who have had an arthroscopy to smooth out their knee cartilage experience pain and difficulties just as often as those who do not have an operation. There are other surgical therapy options available for people with advanced osteoarthritis. For example, a knee or hip joint can be replaced fully or in part with an artificial joint (called an endoprosthesis).

Drugs for Osteoarthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 644)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 9004-61-9 53477741 24759
3
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
4
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2 51-41-2 439260
5
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
6
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 9579578 4594
7
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 156391 1302
8
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
9
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
10
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
11
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
12
Denosumab Approved Phase 4,Phase 2 615258-40-7
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
14
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 175805 71273
15
Hyoscyamine Approved Phase 4 101-31-5 64692
16
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2 51481-61-9 2756
17
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
18
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
19
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
20
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
21
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
22 Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7
23
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
24
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3
25
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
26
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
27
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
28
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
29
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 51-61-6, 62-31-7 681
30
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
31
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
32
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 27203-92-5 33741
33
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
34
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
35
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
36
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
37
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
38 Parecoxib Approved Phase 4,Phase 3 198470-84-7
39
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 46507594 772
40
Chromium Approved Phase 4,Phase 3,Phase 2 7440-47-3 27668
41
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
42
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
43
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
45
Armodafinil Approved, Investigational Phase 4 112111-43-0
46
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
47
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
48
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2 76-57-3 5284371
49
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
50
Infliximab Approved Phase 4 170277-31-3

Interventional clinical trials:

(show top 50) (show all 3403)

# Name Status NCT ID Phase Drugs
1 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
2 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
3 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
4 Comparing Conservative Therapies for the Alleviation of Knee Pain in Knee Osteoarthritis Unknown status NCT02320500 Phase 4
5 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
6 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
7 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
8 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
9 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
10 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
11 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
12 Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients Unknown status NCT02086474 Phase 4 Hyaluronan;Bupivacaine
13 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
14 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
15 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
16 A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis Unknown status NCT00253799 Phase 4
17 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
18 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
19 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
20 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
21 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
22 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
23 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
24 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
25 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
26 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
27 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
28 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
29 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
30 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4 Denosumb;Placebo (for denosumab)
31 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
32 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
33 Artelon Metatarsophalangeal (MTP) Spacer Unknown status NCT01028469 Phase 4
34 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
35 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
36 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
37 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
38 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
39 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
40 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
41 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
42 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
43 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
44 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
45 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
46 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
47 the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee Unknown status NCT02524509 Phase 4
48 Corticosteroids as Additive in Temporomandibular Joint (TMJ) Arthrocentesis Unknown status NCT01275014 Phase 4 Dexamethasone;Isotonic saline
49 Comparison Between Anterior and Direct Lateral Approach in Total Hip Arthroplasty Unknown status NCT01578746 Phase 4
50 Bipolar Sealer Aquamantys Use in Total Knee Replacement Unknown status NCT01736644 Phase 4

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
AlloStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
ReJoin(TM), adipose-derived mesenchymal precursor cell for knee osteoarthritis
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem PMIDs: 22519755
Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem PMIDs: 22500696
Adipose-derived mesenchymal stromal cells PMIDs: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel PMIDs: 17515233 17590152 16510814
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 10102814 14673997 19530993 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell) PMIDs: 22913454
Cultured cartilage (JACC PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Bone marrow-derived mesenchymal stem cells PMIDs: 22750747
Adipose-derived mesenchymal stem cells (family)
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity PMIDs: 21056860 20508015
Sources

Genetic Tests for Osteoarthritis

About this section

Genetic tests related to Osteoarthritis:

# Genetic test Affiliating Genes
1 Osteoarthritis 28
2 Degenerative Joint Disease 28
Sources

Anatomical Context for Osteoarthritis

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Osteoarthritis:

18
Joint

MalaCards organs/tissues related to Osteoarthritis:

38
Bone, Bone Marrow, Testes, Skin, Brain, Liver, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Zeugopod Articular Cartilage Articular Cartilage Cells Affected by disease
2 Cartilage Autopod Articular Cartilage Articular Cartilage Cells Affected by disease
3 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
4 Limb Zeugopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
5 Limb Autopod Synovial Joint Central Intermediate Lamina Cells Affected by disease
6 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
7 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
8 Cartilage Temporomandibular Joint Affected by disease
9 Bone Vertebrae Affected by disease
Sources

Publications for Osteoarthritis

About this section

Articles related to Osteoarthritis:

(show top 50) (show all 2387)
# Title Authors Year
1
The knitting community-based trial for older women with osteoarthritis of the hands: design and rationale of a randomized controlled trial. ( 29444664 )
2018
2
Recent advances in hyaluronic acid based therapy for osteoarthritis. ( 29450666 )
2018
3
Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma: An Observational Study. ( 29448817 )
2018
4
The role of skeletal muscle in the pathophysiology and management of knee osteoarthritis. ( 29444285 )
2018
5
Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. ( 29445972 )
2018
6
A systematic review and meta-analysis of arthroscopic assisted techniques for thumb carpometacarpal joint osteoarthritis. ( 29451099 )
2018
7
Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging. ( 29451138 )
2018
8
Pharmaceutical-grade chondroitin sulfate in the management of knee osteoarthritis. ( 29451036 )
2018
9
Development and persistence of suspected neuropathic pain after total knee arthroplasty in individuals with osteoarthritis. ( 29452296 )
2018
10
Isolated aortic dilation without osteoarthritis: a case of SMAD3 mutation. ( 29444731 )
2018
11
Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. ( 29449014 )
2018
12
Physical activity and Mediterranean diet based on olive tree phenolic compounds from two different geographical areas have protective effects on early osteoarthritis, muscle atrophy and hepatic steatosis. ( 29450729 )
2018
13
Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. ( 29320581 )
2018
14
CORR InsightsAr: Validation of the Chinese (Mandarin) Version of the Oxford Knee Score in Patients with Knee Osteoarthritis. ( 29443846 )
2018
15
The role of fat and inflammation in the pathogenesis and management of osteoarthritis. ( 29444323 )
2018
16
Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: a systematic review. ( 29446485 )
2018
17
Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study. ( 29409410 )
2018
18
Atrophy of hip abductor muscles is related to clinical severity in a hip osteoarthritis population. ( 29446121 )
2018
19
Estimation of Posturographic Trajectory Using k-Nearest Neighbors Classifier in Patients with Rheumatoid Arthritis and Osteoarthritis. ( 29445994 )
2018
20
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. ( 29444976 )
2018
21
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
22
The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study. ( 28942549 )
2017
23
miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. ( 28383548 )
2017
24
Nonoperative Management of Osteochondritis Dissecans of the Knee: Progression to Osteoarthritis and Arthroplasty at Mean 13-Year Follow-up. ( 28812032 )
2017
25
Efficacy and Treatment Response of Intra-articular Corticosteroid Injections in Patients With Symptomatic Knee Osteoarthritis. ( 28953085 )
2017
26
Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. ( 28864651 )
2017
27
Regenerative Cells for the Management of Osteoarthritis and Joint Disorders: A Concise Literature Review. ( 29025215 )
2017
28
Serum transforming growth factor beta1 level for knee osteoarthritis diagnosis. ( 28947355 )
2017
29
Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis. ( 28087567 )
2017
30
Characterization of the Walch B3 glenoid in primary osteoarthritis. ( 28089255 )
2017
31
PNF and manual therapy treatment results of patients with cervical spine osteoarthritis. ( 28946528 )
2017
32
A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty. ( 28943099 )
2017
33
Additional Evidence Supports Association of Common Variants in COL11A1 with Increased Risk of Hip Osteoarthritis Susceptibility. ( 27936936 )
2017
34
Genome-wide DNA methylation profiling of articular cartilage reveals significant epigenetic alterations in Kashin-Beck disease and osteoarthritis. ( 28818737 )
2017
35
Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge For Mir-27b. ( 28934732 )
2017
36
Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). ( 28082368 )
2017
37
Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis. ( 28334504 )
2017
38
Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients. ( 28431586 )
2017
39
Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis. ( 28373711 )
2017
40
Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis. ( 27357308 )
2017
41
A longitudinal comparative study of falls in persons with knee arthroplasty and persons with or at high risk for knee osteoarthritis. ( 28087557 )
2017
42
Gypenoside inhibits interleukin-1I^-induced inflammatory response in human osteoarthritis chondrocytes. ( 28422402 )
2017
43
Modyfied wedge osteotomy for osteoarthritis of elbow secondary to osteochondritis dissecans in adolecent with multiple epiphyseal dysplasia. A case report. ( 28860685 )
2017
44
A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. ( 28481944 )
2017
45
Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis. ( 28063212 )
2017
46
Knee Alignment is Quantitatively Related to Periarticular Bone Morphometry and Density, Especially in those with Osteoarthritis. ( 28940779 )
2017
47
An underlying diagnosis of osteonecrosis of bone is associated with worse outcomes than osteoarthritis after total hip arthroplasty. ( 28068972 )
2017
48
Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis. ( 28526072 )
2017
49
Etoricoxib improves osteoarthritis pain relief, joint function, and quality of life in the extreme elderly. ( 28954205 )
2017
50
Reduced miRa8926a and miRa8926b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation. ( 28000846 )
2017