MCID: OST012
MIFTS: 75

Osteoarthritis malady

Bone diseases category

Summaries for Osteoarthritis

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoarthritis, also known as osteoarthrosis and allied disorder, is related to arthritis and rheumatoid arthritis. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Matrix Metalloproteinases. The drugs indomethacin and sulindac and the compounds actinidin and rhodamine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:9 An arthritis that has material basis in worn out cartilage located in joint.

CDC:4 Osteoarthritis (OA) is a disease of the entire joint involving the cartilage, joint lining, ligaments, and underlying bone. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of OA are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, use of medications, and eventually total joint replacement.

Wikipedia:66 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoarthritis 9 11 46 35 32
osteoarthrosis and allied disorder 9
degenerative joint disease 9
degenerative polyarthritis 63
degenerative arthritis 9
hypertrophic arthritis 9
osteoarthrosis 9


External Ids:

Disease Ontology9 DOID:8398
ICD9CM28 715.3

Related Diseases for Osteoarthritis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.5CTSK, TNFAIP6, MMP13, COL2A1, CTSL
2rheumatoid arthritis31.5CTSK, CTSL, COL2A1, ASPN, MMP13, TNFAIP6
3osteoporosis30.8MMP13, COL2A1, CTSK, CTSL
4multiple epiphyseal dysplasia30.4COL9A1
5osteochondritis dissecans30.1COL9A1
6stickler syndrome30.1COL2A1, COL9A1
7atherosclerosis29.9MMP13, CTSL, CTSK
8giant cell tumor29.8CTSK, CTSL
9synovitis10.6
10blindness10.6
11obesity10.4
12psoriatic arthritis10.3
13spondylosis10.3
14arthropathy10.3
15chondrodysplasia10.3
16spinal stenosis10.3
17hypertension10.3
18spondyloarthropathy10.2
19hypoxia10.2
20osteoporotic fracture10.2
21acromegaly10.2
22hemochromatosis10.2
23reactive arthritis10.2
24osteonecrosis10.2
25gout10.2
26bursitis10.2
27synovial chondromatosis10.2
28osteoarthritis with mild chondrodysplasia10.2
29back pain10.2
30chronic pain10.2
31endotheliitis10.2
32ankylosing spondylitis10.1
33pseudogout10.1
34gastroduodenitis10.1
35cervicitis10.1
36osteochondrosis10.1
37spondylitis10.1
38loeys-dietz syndrome type 310.1
39familial osteochondritis dissecans10.1
40aneurysm10.1
41rheumatic disease10.1
42skeletal dysplasias10.1CTSK, MMP13, COL2A1
43diffuse idiopathic skeletal hyperostosis10.1
44spondylolisthesis10.1
45spondyloepiphyseal dysplasia congenita10.1
46systemic lupus erythematosus10.1
47pseudoachondroplasia10.1
48cartilage disease10.1
49chondromalacia10.1
50enthesopathy10.1

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Symptoms for Osteoarthritis

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Drugs & Therapeutics for Osteoarthritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoarthritis

Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Search CenterWatch for Osteoarthritis

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

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Anatomical Context for Osteoarthritis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Osteoarthritis:

34
Bone, Testes, Skin, Bone marrow, T cells, Endothelial, Adipocyte, Skeletal muscle, Heart, Whole blood, Placenta, B cells, Brain, Prostate

FMA organs/tissues related to Osteoarthritis:

15
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Osteoarthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.4MMP13, COL2A1, COL9A1, CTSK, CTSL, FRZB
2MP:00053719.4CTSK, COL9A1, COL2A1, MMP13, FRZB

Publications for Osteoarthritis

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Sources:
53PubMed
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Articles related to Osteoarthritis:

(show top 50)    (show all 1753)
idTitleAuthorsYear
1
Topical Ginger Treatment With a Compress or Patch for Osteoarthritis Symptoms. (24305660)
2014
2
Ten-year long-term results of total joint arthroplasties with ARPE(R) implant in the treatment of trapeziometacarpal osteoarthritis. (24334554)
2013
3
Evaluation of the degree of knee joint osteoarthritis in patients with early gray hair. (24403769)
2013
4
Quadriceps rate of force development affects gait and function in people with knee osteoarthritis. (24240535)
2013
5
Effects of cognitive task demands on subsequent symptoms and activity in adults with symptomatic osteoarthritis. (24195902)
2013
6
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
7
Efficacy of hyaluronic acid injections in patients with osteoarthritis of the temporomandibular joint. A comparative study. (24220392)
2013
8
Gout and osteoarthritis: a pathogenetic link? (22867976)
2012
9
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis. (22284607)
2012
10
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
11
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. (22340319)
2011
12
Alterations in expression of cartilage-specific genes for aggrecan and collagen type II in osteoarthritis. (21655647)
2011
13
Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. (21199727)
2010
14
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. (20506137)
2010
15
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (20495570)
2010
16
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. (19054821)
2009
17
Expression of MicroRNA-146a in osteoarthritis cartilage. (19333945)
2009
18
Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (19802674)
2009
19
The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. (17676627)
2008
20
Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. (18438860)
2008
21
Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes]. (18683686)
2008
22
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (18240210)
2008
23
Effects of activity strategy training on pain and physical activity in older adults with knee or hip osteoarthritis: a pilot study. (18821646)
2008
24
Osteoarthritis and obesity: experimental models. (19022697)
2008
25
Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients. (18695981)
2008
26
Tramadol extended-release formulations in the management of pain due to osteoarthritis. (18052769)
2007
27
Expression and regulation of the osteoarthritis-associated protein asporin. (17804408)
2007
28
Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. (16889986)
2007
29
Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand. (16396979)
2006
30
Life without COX 2 inhibitors: opioids can be prescribed safely in osteoarthritis. (16777897)
2006
31
Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. (16564620)
2006
32
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
33
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
34
New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease. (15578449)
2005
35
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. (15533759)
2004
36
Comparison of the activities of multinucleated bone-resorbing giant cells derived from CD14-positive cells in the synovial fluids of rheumatoid arthritis and osteoarthritis patients. (14762224)
2004
37
Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (15082485)
2004
38
Expression of collagen type I and type II in consecutive stages of human osteoarthritis. (15316793)
2004
39
Inflammatory cell and cytokine patterns in patients with painful clicking and osteoarthritis in the temporomandibular joint. (14505622)
2003
40
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. (12801482)
2003
41
Association of two gene polymorphisms with osteoarthritis secondary to hip dysplasia. (12360016)
2002
42
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. (11203734)
2000
43
Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. (11005786)
2000
44
Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis. (10451709)
1999
45
Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. (9783757)
1998
46
Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. (9460084)
1998
47
The levels of collagenase, tissue inhibitor of metalloproteinases-1 (TIMP-1), collagenase approximately TIMP-1 complexes and glycosaminoglycan (GAG) in sequential samples of synovial fluid aspirated from patients with osteoarthritis. (7586773)
1995
48
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids. (8886087)
1993
49
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (1569188)
1992
50
Recurrent calcific periarthritis, erosive osteoarthritis and hypophosphatasia: a family study. (2290172)
1990

Variations for Osteoarthritis

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Expression for genes affiliated with Osteoarthritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 31KEGG
See all sources

Compounds for genes affiliated with Osteoarthritis

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1actinidin4610.3CTSL, CTSK
2rhodamine4610.3CTSL, CTSK
3scca14610.3CTSL, CTSK
4thermolysin4610.2MMP13, CTSL
5hydroxyproline46 25 1212.2MMP13, COL2A1, CTSL
6alginate4610.2COL2A1, MMP13
7aprotinin46 1211.1MMP13, CTSK, CTSL
8glycosaminoglycan4610.1COL2A1, MMP13, TNFAIP6
9sid 266815096210.0CTSL, CTSK, CTSV, CTSA
10n-acetyl-l-leucyl-l-leucyl-l-methional6210.0CTSK, CTSV, CTSA, CTSL
11chondroitin sulfate46 2511.0CTSL, CTSK, MMP13, TNFAIP6
12l 0062356210.0CTSK, CTSV, CTSA, CTSL
13e 64d46 6211.0CTSK, CTSV, CTSA, CTSL
14calpeptin46 6211.0CTSK, CTSV, CTSA, CTSL
15aspartate469.9CTSL, CTSK, COL2A1, ASPN
16phenylalanine469.8CTSL, CTSK, MMP13
171,10-phenanthroline46 310.8CTSL, CTSK
18cysteine469.5MMP13, COL2A1, CTSK, CTSV, CTSL
19serine469.4TNFAIP6, MMP13, COL2A1, CTSK, CTSA, CTSL

GO Terms for genes affiliated with Osteoarthritis

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Sources:
17Gene Ontology
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Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.1CTSK, CTSL
2lysosomal lumenGO:0432029.8CTSV, CTSA, CTSL
3extracellular spaceGO:0056159.6CTSL, FRZB, MMP13, CTSK, COL2A1
4extracellular regionGO:0055769.1CTSL, COL2A1, CTSV, MMP13, CTSK, COL9A1

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:03028210.1ASPN, MMP13
2proteolysis involved in cellular protein catabolic processGO:05160310.1CTSL, CTSK
3tissue homeostasisGO:00189410.1COL2A1, COL9A1
4collagen catabolic processGO:0305749.7MMP13, COL2A1, COL9A1, CTSK, CTSL
5proteolysisGO:0065089.6CTSL, CTSK, MMP13
6extracellular matrix disassemblyGO:0226179.5CTSL, CTSV, CTSK, COL9A1, COL2A1, MMP13
7extracellular matrix organizationGO:0301989.5MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:00196810.1CTSL, CTSK
2extracellular matrix structural constituent conferring tensile strengthGO:03002010.1COL9A1, COL2A1
3cysteine-type endopeptidase activityGO:00419710.0CTSL, CTSV, CTSK
4cysteine-type peptidase activityGO:0082349.9CTSL, CTSV, CTSK
5collagen bindingGO:0055189.9ASPN, CTSK, CTSL
6proteoglycan bindingGO:0433949.8CTSL, CTSK

Products for genes affiliated with Osteoarthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoarthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet