MCID: OST012
MIFTS: 76

Osteoarthritis malady

Bone diseases category
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Summaries for Osteoarthritis

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MedlinePlus:33 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Osteoarthritis, also known as osteoarthrosis, is related to arthritis and rheumatoid arthritis, and has symptoms including An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Matrix Metalloproteinases. The drugs indomethacin and sulindac and the compounds rhodamine and actinidin have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:8 An arthritis that has material basis in worn out cartilage located in joint.

CDC:3 Osteoarthritis (OA) is a disease of the entire joint involving the cartilage, joint lining, ligaments, and underlying bone. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of OA are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, use of medications, and eventually total joint replacement.

Wikipedia:65 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

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Osteoarthritis, Aliases & Descriptions:

Name: Osteoarthritis 30 8 10 44 33
Osteoarthrosis 8 62
Osteoarthrosis and Allied Disorder 8
Degenerative Polyarthritis 62
 
Degenerative Joint Disease 8
Hypertrophic Arthritis 8
Degenerative Arthritis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:8398
ICD9CM27 715.3

Related Diseases for Osteoarthritis

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Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.8CTSK, TNFAIP6, MMP13, COL2A1, CTSL
2rheumatoid arthritis31.7CTSK, CTSL, COL2A1, ASPN, MMP13, TNFAIP6
3osteoporosis31.1MMP13, COL2A1, CTSK, CTSL
4multiple epiphyseal dysplasia30.9COL9A1
5osteochondritis dissecans30.7COL9A1
6stickler syndrome30.5COL2A1, COL9A1
7atherosclerosis30.2MMP13, CTSL, CTSK
8giant cell tumor30.0CTSK, CTSL
9synovitis10.6
10blindness10.6
11obesity10.4
12psoriatic arthritis10.3
13skeletal dysplasia multi-gene panels10.3CTSK, MMP13, COL2A1
14spondylosis10.3
15arthropathy10.3
16bone cancer10.3MMP13, CTSL
17chondrodysplasia10.3
18hypertension10.3
19spinal stenosis10.3
20bursitis10.3
21abdominal aortic aneurysm10.3MMP13, CTSL
22kashinÔÇôbeck disease10.2
23spondyloarthropathy10.2
24loeys-dietz syndrome type 310.2
25osteoarthritis with mild chondrodysplasia10.2
26familial osteochondritis dissecans10.2
27hypoxia10.2
28osteonecrosis10.2
29acromegaly10.2
30hemochromatosis10.2
31pseudogout10.2
32reactive arthritis10.2
33gout10.2
34synovial chondromatosis10.2
35back pain10.2
36chronic pain10.2
37osteoporotic fracture10.2
38ankylosing spondylitis10.1
39osteochondrosis10.1
40diffuse idiopathic skeletal hyperostosis10.1
41gastroduodenitis10.1
42cervicitis10.1
43hyperostosis10.1
44spondylitis10.1
45aneurysm10.1
46rheumatic disease10.1
47endotheliitis10.1
48avascular necrosis of the femoral head10.1
49cartilage disease10.1
50spondylolisthesis10.1

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Symptoms for Osteoarthritis

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HPO human phenotypes related to Osteoarthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 heterogeneous HP:0001425
4 multifactorial inheritance HP:0001426
5 abnormality of pelvic girdle bone morphology HP:0002644
6 hip osteoarthritis HP:0008843

Drugs & Therapeutics for Osteoarthritis

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Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

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Anatomical Context for Osteoarthritis

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MalaCards organs/tissues related to Osteoarthritis:

32
Bone, Testes, Skin, Bone marrow, T cells, Adipocyte, Endothelial, Heart, Skeletal muscle, Neutrophil, Whole blood, Brain, Placenta, Prostate, B cells

FMA organs/tissues related to Osteoarthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

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MGI Mouse Phenotypes related to Osteoarthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.4FRZB, MMP13, COL2A1, COL9A1, CTSK, CTSL
2MP:00053719.4FRZB, MMP13, COL2A1, COL9A1, CTSK

Publications for Osteoarthritis

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Articles related to Osteoarthritis:

(show top 50)    (show all 1818)
idTitleAuthorsYear
1
Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis. (25383958)
2014
2
Topical Ginger Treatment With a Compress or Patch for Osteoarthritis Symptoms. (24305660)
2014
3
Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. (25389358)
2014
4
Ten-year long-term results of total joint arthroplasties with ARPE(R) implant in the treatment of trapeziometacarpal osteoarthritis. (24334554)
2013
5
Evaluation of the degree of knee joint osteoarthritis in patients with early gray hair. (24403769)
2013
6
Quadriceps rate of force development affects gait and function in people with knee osteoarthritis. (24240535)
2013
7
Effects of cognitive task demands on subsequent symptoms and activity in adults with symptomatic osteoarthritis. (24195902)
2013
8
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
9
Gout and osteoarthritis: a pathogenetic link? (22867976)
2012
10
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis. (22284607)
2012
11
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
12
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. (22340319)
2011
13
Alterations in expression of cartilage-specific genes for aggrecan and collagen type II in osteoarthritis. (21655647)
2011
14
Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. (21199727)
2010
15
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. (20506137)
2010
16
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (20495570)
2010
17
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. (19054821)
2009
18
Expression of MicroRNA-146a in osteoarthritis cartilage. (19333945)
2009
19
Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (19802674)
2009
20
The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. (17676627)
2008
21
Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. (18438860)
2008
22
Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes]. (18683686)
2008
23
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (18240210)
2008
24
Effects of activity strategy training on pain and physical activity in older adults with knee or hip osteoarthritis: a pilot study. (18821646)
2008
25
Osteoarthritis and obesity: experimental models. (19022697)
2008
26
Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients. (18695981)
2008
27
Tramadol extended-release formulations in the management of pain due to osteoarthritis. (18052769)
2007
28
Expression and regulation of the osteoarthritis-associated protein asporin. (17804408)
2007
29
Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. (16889986)
2007
30
Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand. (16396979)
2006
31
Life without COX 2 inhibitors: opioids can be prescribed safely in osteoarthritis. (16777897)
2006
32
Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. (16564620)
2006
33
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
34
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
35
New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease. (15578449)
2005
36
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. (15533759)
2004
37
Comparison of the activities of multinucleated bone-resorbing giant cells derived from CD14-positive cells in the synovial fluids of rheumatoid arthritis and osteoarthritis patients. (14762224)
2004
38
Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (15082485)
2004
39
Expression of collagen type I and type II in consecutive stages of human osteoarthritis. (15316793)
2004
40
Inflammatory cell and cytokine patterns in patients with painful clicking and osteoarthritis in the temporomandibular joint. (14505622)
2003
41
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. (12801482)
2003
42
Association of two gene polymorphisms with osteoarthritis secondary to hip dysplasia. (12360016)
2002
43
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. (11203734)
2000
44
Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. (11005786)
2000
45
Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis. (10451709)
1999
46
Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. (9783757)
1998
47
The levels of collagenase, tissue inhibitor of metalloproteinases-1 (TIMP-1), collagenase approximately TIMP-1 complexes and glycosaminoglycan (GAG) in sequential samples of synovial fluid aspirated from patients with osteoarthritis. (7586773)
1995
48
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids. (8886087)
1993
49
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (1569188)
1992
50
Recurrent calcific periarthritis, erosive osteoarthritis and hypophosphatasia: a family study. (2290172)
1990

Variations for Osteoarthritis

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Expression for genes affiliated with Osteoarthritis

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Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

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Compounds for genes affiliated with Osteoarthritis

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Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1rhodamine4410.3CTSK, CTSL
2actinidin4410.3CTSL, CTSK
3scca14410.3CTSK, CTSL
4thermolysin4410.2MMP13, CTSL
5hydroxyproline44 24 1112.2COL2A1, MMP13, CTSL
6alginate4410.2MMP13, COL2A1
7aprotinin44 1111.1CTSK, CTSL, MMP13
8glycosaminoglycan4410.1MMP13, TNFAIP6, COL2A1
9n-acetyl-l-leucyl-l-leucyl-l-methional6110.0CTSV, CTSK, CTSL, CTSA
10sid 266815096110.0CTSL, CTSA, CTSV, CTSK
11chondroitin sulfate44 2411.0CTSL, CTSK, MMP13, TNFAIP6
12l 0062356110.0CTSL, CTSA, CTSV, CTSK
13e 64d44 6111.0CTSK, CTSV, CTSA, CTSL
14calpeptin44 6111.0CTSL, CTSA, CTSV, CTSK
15aspartate449.9CTSL, ASPN, CTSK, COL2A1
16phenylalanine449.8CTSL, CTSK, MMP13
171,10-phenanthroline44 210.8CTSK, CTSL
18cysteine449.5CTSV, CTSK, COL2A1, MMP13, CTSL
19serine449.4CTSK, CTSA, CTSL, COL2A1, MMP13, TNFAIP6

GO Terms for genes affiliated with Osteoarthritis

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Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.1CTSL, CTSK
2lysosomal lumenGO:0432029.8CTSL, CTSA, CTSV
3extracellular spaceGO:0056159.6CTSL, CTSK, COL2A1, MMP13, FRZB
4extracellular regionGO:0055769.1MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:03028210.1ASPN, MMP13
2proteolysis involved in cellular protein catabolic processGO:05160310.1CTSL, CTSK
3tissue homeostasisGO:00189410.1COL2A1, COL9A1
4collagen catabolic processGO:0305749.7MMP13, COL2A1, COL9A1, CTSK, CTSL
5proteolysisGO:0065089.6CTSL, CTSK, MMP13
6extracellular matrix disassemblyGO:0226179.5CTSL, CTSV, CTSK, COL9A1, COL2A1, MMP13
7extracellular matrix organizationGO:0301989.5MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:00196810.1CTSL, CTSK
2extracellular matrix structural constituent conferring tensile strengthGO:03002010.1COL9A1, COL2A1
3cysteine-type endopeptidase activityGO:00419710.0CTSL, CTSV, CTSK
4cysteine-type peptidase activityGO:0082349.9CTSL, CTSV, CTSK
5collagen bindingGO:0055189.9ASPN, CTSK, CTSL
6proteoglycan bindingGO:0433949.8CTSL, CTSK

Products for genes affiliated with Osteoarthritis

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  • Antibodies
  • Proteins
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Sources for Osteoarthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet