Osteoarthritis malady

Bone diseases category

Summaries for Osteoarthritis

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MedlinePlus:33 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Osteoarthritis, also known as osteoarthrosis, is related to arthritis and rheumatoid arthritis, and has symptoms including autosomal dominant inheritance, autosomal recessive inheritance and heterogeneous. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Matrix Metalloproteinases. The drugs aspirin and chondroitin and the compounds actinidin and rhodamine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:9 An arthritis that has material basis in worn out cartilage located in joint.

CDC:4 Osteoarthritis (OA) is a disease of the entire joint involving the cartilage, joint lining, ligaments, and underlying bone. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of OA are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, use of medications, and eventually total joint replacement.

Wikipedia:64 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

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Osteoarthritis, Aliases & Descriptions:

Name: Osteoarthritis 31 9 11 44 33
Osteoarthrosis 9 61
Osteoarthrosis and Allied Disorder 9
Degenerative Polyarthritis 61
Degenerative Joint Disease 9
Hypertrophic Arthritis 9
Degenerative Arthritis 9


Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases

External Ids:

Disease Ontology9 DOID:8398
ICD9CM28 715.3

Related Diseases for Osteoarthritis

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Diseases in the Osteoarthritis family:


Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.8TNFAIP6, MMP13, COL2A1, CTSK, CTSL
2rheumatoid arthritis31.7TNFAIP6, MMP13, ASPN, COL2A1, CTSK, CTSL
3osteoporosis31.1MMP13, COL2A1, CTSK, CTSL
4multiple epiphyseal dysplasia30.9COL9A1
5osteochondritis dissecans30.7COL9A1
6stickler syndrome30.5COL9A1, COL2A1
7atherosclerosis30.2CTSL, CTSK, MMP13
8giant cell tumor30.0CTSK, CTSL
12psoriatic arthritis10.3
13skeletal dysplasia multi-gene panels10.3CTSK, COL2A1, MMP13
16bone cancer10.3MMP13, CTSL
19spinal stenosis10.3
21abdominal aortic aneurysm10.3CTSL, MMP13
22kashin-beck disease10.2
24loeys-dietz syndrome type 310.2
25osteoarthritis with mild chondrodysplasia10.2
26familial osteochondritis dissecans10.2
32reactive arthritis10.2
34synovial chondromatosis10.2
35back pain10.2
36chronic pain10.2
37osteoporotic fracture10.2
38ankylosing spondylitis10.1
40diffuse idiopathic skeletal hyperostosis10.1
46rheumatic disease10.1
48avascular necrosis of the femoral head10.1
49cartilage disease10.1

Graphical network of the top 20 diseases related to Osteoarthritis:

Diseases related to osteoarthritis

Symptoms for Osteoarthritis

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HPO human phenotypes related to Osteoarthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 heterogeneous HP:0001425
4 multifactorial inheritance HP:0001426
5 abnormality of pelvic girdle bone morphology HP:0002644
6 hip osteoarthritis HP:0008843

Drugs & Therapeutics for Osteoarthritis

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Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

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Anatomical Context for Osteoarthritis

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MalaCards organs/tissues related to Osteoarthritis:

Bone, Testes, Skin, Bone marrow, T cells, Adipocyte, Endothelial, Heart, Skeletal muscle, Neutrophil, Whole blood, Brain, Placenta, Prostate, B cells

FMA organs/tissues related to Osteoarthritis:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

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MGI Mouse Phenotypes related to Osteoarthritis:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.4MMP13, COL2A1, COL9A1, CTSK, CTSL, FRZB
2MP:00053719.4CTSK, COL9A1, COL2A1, MMP13, FRZB

Publications for Osteoarthritis

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Articles related to Osteoarthritis:

(show top 50)    (show all 1818)
Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis. (25383958)
Topical Ginger Treatment With a Compress or Patch for Osteoarthritis Symptoms. (24305660)
Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. (25389358)
Ten-year long-term results of total joint arthroplasties with ARPE(R) implant in the treatment of trapeziometacarpal osteoarthritis. (24334554)
Evaluation of the degree of knee joint osteoarthritis in patients with early gray hair. (24403769)
Quadriceps rate of force development affects gait and function in people with knee osteoarthritis. (24240535)
Effects of cognitive task demands on subsequent symptoms and activity in adults with symptomatic osteoarthritis. (24195902)
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
Gout and osteoarthritis: a pathogenetic link? (22867976)
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis. (22284607)
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. (22340319)
Alterations in expression of cartilage-specific genes for aggrecan and collagen type II in osteoarthritis. (21655647)
Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. (21199727)
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. (20506137)
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (20495570)
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. (19054821)
Expression of MicroRNA-146a in osteoarthritis cartilage. (19333945)
Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (19802674)
The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. (17676627)
Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. (18438860)
Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes]. (18683686)
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (18240210)
Effects of activity strategy training on pain and physical activity in older adults with knee or hip osteoarthritis: a pilot study. (18821646)
Osteoarthritis and obesity: experimental models. (19022697)
Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients. (18695981)
Tramadol extended-release formulations in the management of pain due to osteoarthritis. (18052769)
Expression and regulation of the osteoarthritis-associated protein asporin. (17804408)
Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. (16889986)
Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand. (16396979)
Life without COX 2 inhibitors: opioids can be prescribed safely in osteoarthritis. (16777897)
Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. (16564620)
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease. (15578449)
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. (15533759)
Comparison of the activities of multinucleated bone-resorbing giant cells derived from CD14-positive cells in the synovial fluids of rheumatoid arthritis and osteoarthritis patients. (14762224)
Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (15082485)
Expression of collagen type I and type II in consecutive stages of human osteoarthritis. (15316793)
Inflammatory cell and cytokine patterns in patients with painful clicking and osteoarthritis in the temporomandibular joint. (14505622)
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. (12801482)
Association of two gene polymorphisms with osteoarthritis secondary to hip dysplasia. (12360016)
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. (11203734)
Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. (11005786)
Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis. (10451709)
Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. (9783757)
The levels of collagenase, tissue inhibitor of metalloproteinases-1 (TIMP-1), collagenase approximately TIMP-1 complexes and glycosaminoglycan (GAG) in sequential samples of synovial fluid aspirated from patients with osteoarthritis. (7586773)
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids. (8886087)
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (1569188)
Recurrent calcific periarthritis, erosive osteoarthritis and hypophosphatasia: a family study. (2290172)

Variations for Osteoarthritis

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Expression for genes affiliated with Osteoarthritis

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2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Osteoarthritis patients vs. healthy controls: 31 (show all 391)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Cartilage-6.040.000
2FOSBFBJ murine osteosarcoma viral oncogene homolog BCartilage-5.130.000
3IGLimmunoglobulin lambda locusCartilage+5.030.000
4MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FCartilage-4.560.000
5ANGPTL7angiopoietin-like 7Cartilage-4.420.000
6LTC4Sleukotriene C4 synthaseCartilage+4.420.000
7IGKCimmunoglobulin kappa constantCartilage+4.310.000
8IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesCartilage+4.290.000
9FAM107Afamily with sequence similarity 107, member ACartilage-4.260.000
10HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Cartilage+4.250.001
11MMP1matrix metallopeptidase 1 (interstitial collagenase)Cartilage+4.230.000
12IGLJ3immunoglobulin lambda joining 3Cartilage+4.050.000
13APODapolipoprotein DCartilage-4.050.000
14JUNjun proto-oncogeneCartilage-4.030.000
15NFIL3nuclear factor, interleukin 3 regulatedCartilage-3.800.000
16SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3Cartilage-3.760.000
17SLCO4A1solute carrier organic anion transporter family, member 4A1Cartilage-3.730.000
18TPPP3tubulin polymerization-promoting protein family member 3Cartilage+3.700.000
19GADD45Bgrowth arrest and DNA-damage-inducible, betaCartilage-3.660.000
20CXCL2chemokine (C-X-C motif) ligand 2Cartilage-3.660.000
21IGHMimmunoglobulin heavy constant muCartilage+3.620.000
22CSN1S1casein alpha s1Cartilage+3.580.008
23IL8interleukin 8Cartilage-3.560.000
24CXCL3chemokine (C-X-C motif) ligand 3Cartilage-3.550.000
25ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideCartilage-3.550.000
26FOSL2FOS-like antigen 2Cartilage-3.540.000
27VEGFAvascular endothelial growth factor ACartilage-3.540.000
28IGLV2-23immunoglobulin lambda variable 2-23Cartilage+3.530.001
29FKBP5FK506 binding protein 5Cartilage-3.520.003
30ADCY2adenylate cyclase 2 (brain)Cartilage-3.500.000
31CX3CR1chemokine (C-X3-C motif) receptor 1Cartilage+3.470.000
32IGKV1-5immunoglobulin kappa variable 1-5Cartilage+3.390.000
33MXRA5matrix-remodelling associated 5Cartilage+3.380.000
34APOLD1apolipoprotein L domain containing 1Cartilage-3.370.000
35TNFSF11tumor necrosis factor (ligand) superfamily, member 11Cartilage+3.360.000
36SIK1salt-inducible kinase 1Cartilage-3.340.000
37DDIT4DNA-damage-inducible transcript 4Cartilage-3.330.000
38GAP43growth associated protein 43Cartilage+3.310.001
39PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Cartilage-3.290.000
41MUC1mucin 1, cell surface associatedCartilage-3.270.000
42PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Cartilage-3.270.000
43DUSP2dual specificity phosphatase 2Cartilage-3.250.000
44CD52CD52 moleculeCartilage+3.210.000
45PLXNC1plexin C1Cartilage+3.200.000
46SOD2superoxide dismutase 2, mitochondrialCartilage-3.200.000
47SDC1syndecan 1Cartilage+3.190.000
48CEBPDCCAAT/enhancer binding protein (C/EBP), deltaCartilage-3.180.000
49NR4A2nuclear receptor subfamily 4, group A, member 2Cartilage-3.180.000
50ATF3activating transcription factor 3Cartilage-3.180.000
51DOCK10dedicator of cytokinesis 10Cartilage+3.110.000
52ADAM12ADAM metallopeptidase domain 12Cartilage+3.070.000
53RRADRas-related associated with diabetesCartilage-3.070.001
54WNT5Bwingless-type MMTV integration site family, member 5BCartilage+3.070.000
55KLF9Kruppel-like factor 9Cartilage-3.060.000
56TREM2triggering receptor expressed on myeloid cells 2Cartilage+3.050.000
57MFAP5microfibrillar associated protein 5Cartilage-3.050.013
58IGKV4-1immunoglobulin kappa variable 4-1Cartilage+3.040.008
59PART1prostate androgen-regulated transcript 1 (non-protein coding)Cartilage+3.030.000
60SLC16A7solute carrier family 16 (monocarboxylate transporter), member 7Cartilage-3.010.000
61SCRG1stimulator of chondrogenesis 1Cartilage+2.990.000
62LST1leukocyte specific transcript 1Cartilage+2.990.000
63PER1period circadian clock 1Cartilage-2.980.000
64NAMPTnicotinamide phosphoribosyltransferaseCartilage-2.980.000
65COL1A1collagen, type I, alpha 1Cartilage+2.970.000
66FAPfibroblast activation protein, alphaCartilage+2.970.001
67CCL20chemokine (C-C motif) ligand 20Cartilage-2.950.028
68GADD45Agrowth arrest and DNA-damage-inducible, alphaCartilage-2.920.000
69GJA4gap junction protein, alpha 4, 37kDaCartilage-2.910.001
71ARCactivity-regulated cytoskeleton-associated proteinCartilage-2.850.006
72MT1Mmetallothionein 1MCartilage-2.850.000
73IGLV3-19immunoglobulin lambda variable 3-19Cartilage+2.840.004
74RPS4Y1ribosomal protein S4, Y-linked 1Cartilage-2.830.033
75IL6interleukin 6 (interferon, beta 2)Cartilage-2.820.006
76SLC19A2solute carrier family 19 (thiamine transporter), member 2Cartilage-2.810.000
77GRB10growth factor receptor-bound protein 10Cartilage-2.800.000
78SORL1sortilin-related receptor, L(DLR class) A repeats containingCartilage+2.790.000
79PTGDSprostaglandin D2 synthase 21kDa (brain)Cartilage+2.770.000
80PLIN2perilipin 2Cartilage-2.760.000
81DUOX2dual oxidase 2Cartilage-2.750.001
82HK3hexokinase 3 (white cell)Cartilage+2.740.001
83MESTmesoderm specific transcriptCartilage+2.720.000
84CCDC102Bcoiled-coil domain containing 102BCartilage+2.720.003
85MTSS1metastasis suppressor 1Cartilage-2.710.000
86NPAS2neuronal PAS domain protein 2Cartilage-2.700.001
87ZBTB16zinc finger and BTB domain containing 16Cartilage-2.680.000
88PTPRCprotein tyrosine phosphatase, receptor type, CCartilage+2.680.002
89LDLRlow density lipoprotein receptorCartilage-2.670.005
90ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3Cartilage+2.660.000
91DUSP1dual specificity phosphatase 1Cartilage-2.660.008
92LRRC15leucine rich repeat containing 15Cartilage+2.650.001
94IGHDimmunoglobulin heavy constant deltaCartilage+2.640.004
95TLR7toll-like receptor 7Cartilage+2.640.000
96NCF1Cneutrophil cytosolic factor 1C pseudogeneCartilage+2.640.001
97ZC3H12Azinc finger CCCH-type containing 12ACartilage-2.630.003
98LGI2leucine-rich repeat LGI family, member 2Cartilage+2.620.001
99RGS1regulator of G-protein signaling 1Cartilage-2.620.012
100LBPlipopolysaccharide binding proteinCartilage-2.620.034
101MYCv-myc avian myelocytomatosis viral oncogene homologCartilage-2.600.000
102PPP1R15Aprotein phosphatase 1, regulatory subunit 15ACartilage-2.600.000
103IL1R2interleukin 1 receptor, type IICartilage-2.570.005
104ZFP36L2ZFP36 ring finger protein-like 2Cartilage-2.560.004
105HLA-DQB1major histocompatibility complex, class II, DQ beta 1Cartilage+2.540.001
106XISTX inactive specific transcript (non-protein coding)Cartilage+2.520.035
107LAMA3laminin, alpha 3Cartilage-2.510.010
108LIFleukemia inhibitory factorCartilage-2.500.049
109CDH19cadherin 19, type 2Cartilage-2.490.005
110EPHB2EPH receptor B2Cartilage+2.490.000
111AIF1allograft inflammatory factor 1Cartilage+2.480.001
112MGAT4Cmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)Cartilage+2.480.000
113SLC18A2solute carrier family 18 (vesicular monoamine transporter), member 2Cartilage+2.480.001
114POU2AF1POU class 2 associating factor 1Cartilage+2.470.008
115LAIR1leukocyte-associated immunoglobulin-like receptor 1Cartilage+2.470.003
116PTX3pentraxin 3, longCartilage-2.470.026
117CYR61cysteine-rich, angiogenic inducer, 61Cartilage-2.440.000
118KLF4Kruppel-like factor 4 (gut)Cartilage-2.440.000
119EPHA3EPH receptor A3Cartilage+2.430.019
120PIGAphosphatidylinositol glycan anchor biosynthesis, class ACartilage-2.430.000
121LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Cartilage+2.430.019
122TNFAIP3tumor necrosis factor, alpha-induced protein 3Cartilage-2.430.000
123TAF9BTAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDaCartilage+2.430.040
124CHST7carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7Cartilage-2.430.025
125FAM198Bfamily with sequence similarity 198, member BCartilage+2.430.019
126OSBPL3oxysterol binding protein-like 3Cartilage+2.420.000
127MCOLN3mucolipin 3Cartilage+2.420.003
128C10orf10chromosome 10 open reading frame 10Cartilage-2.420.001
129FLRT2fibronectin leucine rich transmembrane protein 2Cartilage+2.420.000
130NREPneuronal regeneration related proteinCartilage+2.410.000
131MYOCmyocilin, trabecular meshwork inducible glucocorticoid responseCartilage-2.410.004
132ARHGAP25Rho GTPase activating protein 25Cartilage+2.410.005
133ME2malic enzyme 2, NAD(+)-dependent, mitochondrialCartilage+2.410.001
134CXADRcoxsackie virus and adenovirus receptorCartilage+2.410.001
135EIF1eukaryotic translation initiation factor 1Cartilage-2.410.002
136ZFP36ZFP36 ring finger proteinCartilage-2.410.000
137PSPHphosphoserine phosphataseCartilage+2.410.049
138CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Cartilage-2.400.000
139CALML4calmodulin-like 4Cartilage+2.390.000
140STC1stanniocalcin 1Cartilage-2.390.001
141TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)Cartilage-2.380.000
142IGKV3-20immunoglobulin kappa variable 3-20Cartilage+2.380.010
143MTUS2microtubule associated tumor suppressor candidate 2Cartilage+2.380.005
144IGHG1immunoglobulin heavy constant gamma 1 (G1m marker)Cartilage+2.370.011
145IL1Binterleukin 1, betaCartilage-2.370.000
146NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaCartilage-2.360.000
147TPSAB1tryptase alpha/beta 1Cartilage+2.360.019
148GPR65G protein-coupled receptor 65Cartilage+2.360.007
149SLC5A3solute carrier family 5 (sodium/myo-inositol cotransporter), member 3Cartilage+2.340.000
150ELL2elongation factor, RNA polymerase II, 2Cartilage-2.330.010
151OLR1oxidized low density lipoprotein (lectin-like) receptor 1Cartilage+2.330.001
152LRRC17leucine rich repeat containing 17Cartilage+2.320.000
153SLC7A5solute carrier family 7 (amino acid transporter light chain, L system), member 5Cartilage-2.320.025
154DARCDuffy blood group, atypical chemokine receptorCartilage-2.310.015
155IGLL3Pimmunoglobulin lambda-like polypeptide 3, pseudogeneCartilage+2.310.004
156TNFRSF25tumor necrosis factor receptor superfamily, member 25Cartilage+2.310.004
158CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)Cartilage+2.290.016
159GPR1G protein-coupled receptor 1Cartilage+2.290.012
160FADS1fatty acid desaturase 1Cartilage-2.280.036
161KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Cartilage+2.280.027
163SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Cartilage-2.280.010
164HTR2B5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupledCartilage+2.270.017
165SOCS3suppressor of cytokine signaling 3Cartilage-2.260.003
166NR4A1nuclear receptor subfamily 4, group A, member 1Cartilage-2.260.009
168FZD8frizzled class receptor 8Cartilage+2.260.001
169KAL1Kallmann syndrome 1 sequenceCartilage+2.250.000
170ANKHANKH inorganic pyrophosphate transport regulatorCartilage+2.250.004
171ACADLacyl-CoA dehydrogenase, long chainCartilage-2.250.007
172UCP2uncoupling protein 2 (mitochondrial, proton carrier)Cartilage+2.250.000
173TMEM51transmembrane protein 51Cartilage+2.240.007
174DDX24DEAD (Asp-Glu-Ala-Asp) box helicase 24Cartilage-2.240.015
175MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Cartilage+2.240.003
176NID2nidogen 2 (osteonidogen)Cartilage+2.240.000
177CRIP1cysteine-rich protein 1 (intestinal)Cartilage+2.230.000
178TTC3tetratricopeptide repeat domain 3Cartilage+2.230.003
179TAC1tachykinin, precursor 1Cartilage+2.230.023
180CCL5chemokine (C-C motif) ligand 5Cartilage+2.210.014
181BSCL2Berardinelli-Seip congenital lipodystrophy 2 (seipin)Cartilage+2.210.004
183MED8mediator complex subunit 8Cartilage+2.180.034
184CDH2cadherin 2, type 1, N-cadherin (neuronal)Cartilage+2.170.021
185RRM2ribonucleotide reductase M2Cartilage+2.170.004
186COL1A2collagen, type I, alpha 2Cartilage+2.160.002
187C5orf54chromosome 5 open reading frame 54Cartilage+2.160.021
188HLA-DPA1major histocompatibility complex, class II, DP alpha 1Cartilage+2.160.001
189CECR1cat eye syndrome chromosome region, candidate 1Cartilage+2.150.004
190PIM1pim-1 oncogeneCartilage-2.140.000
191CRISPLD2cysteine-rich secretory protein LCCL domain containing 2Cartilage-2.140.003
192EGR1early growth response 1Cartilage-2.130.004
193HLA-DMBmajor histocompatibility complex, class II, DM betaCartilage+2.130.000
194ENC1ectodermal-neural cortex 1 (with BTB domain)Cartilage+2.130.007
195FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideCartilage+2.120.000
196GM2AGM2 ganglioside activatorCartilage+2.120.012
197ZBTB43zinc finger and BTB domain containing 43Cartilage-2.120.015
198IKZF1IKAROS family zinc finger 1 (Ikaros)Cartilage+2.120.021
199KAZALD1Kazal-type serine peptidase inhibitor domain 1Cartilage+2.120.003
200MAOAmonoamine oxidase ACartilage-2.110.016
201ZNF135zinc finger protein 135Cartilage+2.110.040
202BCL6B-cell CLL/lymphoma 6Cartilage-2.100.000
203CBX6chromobox homolog 6Cartilage+2.100.004
204C1QTNF3C1q and tumor necrosis factor related protein 3Cartilage+2.090.001
205JUNDjun D proto-oncogeneCartilage-2.090.001
206LAMA2laminin, alpha 2Cartilage-2.090.011
207BTN3A1butyrophilin, subfamily 3, member A1Cartilage+2.090.031
208RGS2regulator of G-protein signaling 2, 24kDaCartilage-2.090.000
209SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Cartilage-2.090.005
210FNDC4fibronectin type III domain containing 4Cartilage-2.070.002
211NELL1NEL-like 1 (chicken)Cartilage+2.070.018
212TRIM14tripartite motif containing 14Cartilage+2.070.006
213REREarginine-glutamic acid dipeptide (RE) repeatsCartilage-2.070.022
214APLNRapelin receptorCartilage+2.070.014
215CCNL1cyclin L1Cartilage-2.070.000
216SYNE1spectrin repeat containing, nuclear envelope 1Cartilage-2.050.022
217GOLM1golgi membrane protein 1Cartilage+2.050.001
218SNORA21small nucleolar RNA, H/ACA box 21Cartilage-2.050.009
219GAMTguanidinoacetate N-methyltransferaseCartilage+2.050.004
220RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Cartilage+2.050.019
221RTN1reticulon 1Cartilage+2.040.015
222IRAK3interleukin-1 receptor-associated kinase 3Cartilage-2.040.005
223ATMataxia telangiectasia mutatedCartilage+2.040.031
224CXCL12chemokine (C-X-C motif) ligand 12Cartilage+2.040.000
225RHOBras homolog family member BCartilage-2.030.000
226EIF4A1eukaryotic translation initiation factor 4A1Cartilage-2.020.000
227CLEC4AC-type lectin domain family 4, member ACartilage+2.020.011
228TRAF3IP3TRAF3 interacting protein 3Cartilage+2.020.025
229TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, NFKB activatorCartilage+2.010.011
230GCH1GTP cyclohydrolase 1Cartilage-2.010.018
231AASSaminoadipate-semialdehyde synthaseCartilage-2.010.034
232CIITAclass II, major histocompatibility complex, transactivatorCartilage+2.010.004
233TIMP4TIMP metallopeptidase inhibitor 4Cartilage-2.000.005
234ALDH5A1aldehyde dehydrogenase 5 family, member A1Cartilage+2.000.014
235LMOD1leiomodin 1 (smooth muscle)Cartilage-1.990.047
236COL14A1collagen, type XIV, alpha 1Cartilage+1.990.013
237IER5immediate early response 5Cartilage-1.990.000
238HAS1hyaluronan synthase 1Cartilage-1.990.010
239CLDN5claudin 5Cartilage-1.990.031
240TOP2Atopoisomerase (DNA) II alpha 170kDaCartilage+1.980.014
241PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaCartilage-1.970.014
242CORO1Acoronin, actin binding protein, 1ACartilage+1.970.008
243MT1Xmetallothionein 1XCartilage-1.960.002
244PHKA1phosphorylase kinase, alpha 1 (muscle)Cartilage-1.960.017
245GPER1G protein-coupled estrogen receptor 1Cartilage+1.960.013
246SLC6A3solute carrier family 6 (neurotransmitter transporter), member 3Cartilage-1.960.044
247COL3A1collagen, type III, alpha 1Cartilage+1.950.002
248GPR56G protein-coupled receptor 56Cartilage-1.950.023
249CBR1carbonyl reductase 1Cartilage+1.950.031
250COL5A1collagen, type V, alpha 1Cartilage+1.950.005
251GDF15growth differentiation factor 15Cartilage-1.940.046
254LIPClipase, hepaticCartilage+1.930.007
255HNRNPMheterogeneous nuclear ribonucleoprotein MCartilage-1.930.026
256CDKAL1CDK5 regulatory subunit associated protein 1-like 1Cartilage+1.930.039
257CD37CD37 moleculeCartilage+1.930.041
258PCDH12protocadherin 12Cartilage+1.930.012
259WWC1WW and C2 domain containing 1Cartilage+1.920.039
260HIST1H2BGhistone cluster 1, H2bgCartilage-1.920.037
261ZNF528zinc finger protein 528Cartilage+1.920.021
262ZFAND5zinc finger, AN1-type domain 5Cartilage-1.920.001
263RND1Rho family GTPase 1Cartilage-1.920.005
264SDC3syndecan 3Cartilage+1.910.019
265BAG3BCL2-associated athanogene 3Cartilage-1.910.001
266IFI30interferon, gamma-inducible protein 30Cartilage+1.900.014
267INHBBinhibin, beta BCartilage-1.900.014
268MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseCartilage-1.900.000
269MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2Cartilage-1.890.029
270THY1Thy-1 cell surface antigenCartilage+1.890.003
271IER3immediate early response 3Cartilage-1.890.041
272THBS1thrombospondin 1Cartilage-1.890.030
273BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Cartilage+1.890.010
274WEE1WEE1 G2 checkpoint kinaseCartilage-1.880.008
275SLC39A14solute carrier family 39 (zinc transporter), member 14Cartilage-1.880.001
276IRS2insulin receptor substrate 2Cartilage-1.880.005
277CD84CD84 moleculeCartilage+1.880.049
278TIPARPTCDD-inducible poly(ADP-ribose) polymeraseCartilage-1.870.000
279ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)Cartilage+1.870.040
280PTHLHparathyroid hormone-like hormoneCartilage+1.870.046
281RTP4receptor (chemosensory) transporter protein 4Cartilage+1.860.016
282GUCA1Aguanylate cyclase activator 1A (retina)Cartilage+1.860.007
283LAMA4laminin, alpha 4Cartilage+1.860.025
284GPR183G protein-coupled receptor 183Cartilage-1.860.004
285SLC23A2solute carrier family 23 (ascorbic acid transporter), member 2Cartilage+1.860.003
286UBA7ubiquitin-like modifier activating enzyme 7Cartilage+1.850.019
287PLD1phospholipase D1, phosphatidylcholine-specificCartilage+1.850.035
288BTN3A3butyrophilin, subfamily 3, member A3Cartilage+1.840.023
289SYKspleen tyrosine kinaseCartilage+1.830.013
290MT1Fmetallothionein 1FCartilage-1.830.005
291GPR4G protein-coupled receptor 4Cartilage-1.830.035
292SEMA3Bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3BCartilage+1.830.034
294PER3period circadian clock 3Cartilage+1.820.029
295TFRCtransferrin receptorCartilage-1.820.014
296SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)Cartilage+1.820.032
297H1FXH1 histone family, member XCartilage-1.810.009
298CD44CD44 molecule (Indian blood group)Cartilage-1.810.048
299CD58CD58 moleculeCartilage+1.800.047
300CEBPACCAAT/enhancer binding protein (C/EBP), alphaCartilage+1.790.017
301KIF20Akinesin family member 20ACartilage+1.790.007
302FLT1fms-related tyrosine kinase 1Cartilage-1.780.028
303SYT17synaptotagmin XVIICartilage+1.780.027
304MAP3K8mitogen-activated protein kinase kinase kinase 8Cartilage-1.780.010
305ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Cartilage-1.780.001
306TTLL1tubulin tyrosine ligase-like family, member 1Cartilage+1.770.022
307KCTD14potassium channel tetramerization domain containing 14Cartilage-1.770.034
308ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5Cartilage-1.760.019
309TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Cartilage-1.760.011
310IL15RAinterleukin 15 receptor, alphaCartilage-1.760.037
311KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 1Cartilage+1.760.028
312HLA-DPB1major histocompatibility complex, class II, DP beta 1Cartilage+1.760.001
313SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DCartilage+1.750.044
314MRC2mannose receptor, C type 2Cartilage+1.750.000
315BTG2BTG family, member 2Cartilage-1.750.000
316SLIT3slit homolog 3 (Drosophila)Cartilage+1.750.027
317RHOBTB1Rho-related BTB domain containing 1Cartilage+1.750.017
318LTA4Hleukotriene A4 hydrolaseCartilage+1.750.009
319DNAJC10DnaJ (Hsp40) homolog, subfamily C, member 10Cartilage+1.720.023
320RPGRretinitis pigmentosa GTPase regulatorCartilage-1.720.003
321DYRK3dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3Cartilage-1.710.043
322PNRC1proline-rich nuclear receptor coactivator 1Cartilage-1.710.004
323ANK3ankyrin 3, node of Ranvier (ankyrin G)Cartilage+1.700.013
324DUSP5dual specificity phosphatase 5Cartilage-1.700.008
325ABCA2ATP-binding cassette, sub-family A (ABC1), member 2Cartilage+1.690.029
326CSF1Rcolony stimulating factor 1 receptorCartilage+1.690.008
327JUNBjun B proto-oncogeneCartilage-1.680.017
328PPAP2Bphosphatidic acid phosphatase type 2BCartilage-1.670.022
329CBLBCbl proto-oncogene B, E3 ubiquitin protein ligaseCartilage-1.670.009
330KLF6Kruppel-like factor 6Cartilage-1.670.007
331CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Cartilage+1.660.047
332TTC9tetratricopeptide repeat domain 9Cartilage+1.660.047
333ISLRimmunoglobulin superfamily containing leucine-rich repeatCartilage+1.650.009
334MSR1macrophage scavenger receptor 1Cartilage+1.650.043
335ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4Cartilage+1.650.045
336SIAH2siah E3 ubiquitin protein ligase 2Cartilage-1.650.021
337EDNRBendothelin receptor type BCartilage-1.640.015
338GAL3ST4galactose-3-O-sulfotransferase 4Cartilage+1.640.001
339MT1Gmetallothionein 1GCartilage-1.630.004
340IFRD1interferon-related developmental regulator 1Cartilage-1.630.006
341TYROBPTYRO protein tyrosine kinase binding proteinCartilage+1.630.010
342GLRXglutaredoxin (thioltransferase)Cartilage-1.620.019
343FBP1fructose-1,6-bisphosphatase 1Cartilage+1.620.017
344KLF2Kruppel-like factor 2Cartilage-1.610.001
345SPENspen family transcriptional repressorCartilage-1.610.024
346GABARAPL1GABA(A) receptor-associated protein like 1Cartilage-1.610.007
347CAPGcapping protein (actin filament), gelsolin-likeCartilage+1.610.034
348LRMPlymphoid-restricted membrane proteinCartilage+1.610.028
349DDX21DEAD (Asp-Glu-Ala-Asp) box helicase 21Cartilage-1.600.019
350CCDC69coiled-coil domain containing 69Cartilage-1.600.021
351KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4Cartilage+1.600.047
352CLEC3BC-type lectin domain family 3, member BCartilage+1.600.005
353IER2immediate early response 2Cartilage-1.590.020
354H3F3BH3 histone, family 3B (H3.3B)Cartilage-1.590.015
355ANGPTL2angiopoietin-like 2Cartilage+1.590.020
356MARCKSmyristoylated alanine-rich protein kinase C substrateCartilage+1.590.007
357TRILTLR4 interactor with leucine-rich repeatsCartilage+1.590.019
358AP4M1adaptor-related protein complex 4, mu 1 subunitCartilage+1.590.027
359DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 1Cartilage-1.590.006
360SRSF7serine/arginine-rich splicing factor 7Cartilage-1.580.019
361RCN3reticulocalbin 3, EF-hand calcium binding domainCartilage+1.580.033
362ARNTLaryl hydrocarbon receptor nuclear translocator-likeCartilage-1.570.037
363COL5A2collagen, type V, alpha 2Cartilage+1.570.032
364HMGB2high mobility group box 2Cartilage-1.570.013
365TRA2Btransformer 2 beta homolog (Drosophila)Cartilage-1.560.043
366FOXO3forkhead box O3Cartilage-1.560.029
367CRABP2cellular retinoic acid binding protein 2Cartilage+1.560.027
368TRBC1T cell receptor beta constant 1Cartilage+1.550.031
369SULF1sulfatase 1Cartilage+1.550.014
370JMJD4jumonji domain containing 4Cartilage+1.550.036
371TRDT cell receptor delta locusCartilage+1.550.047
372CCL8chemokine (C-C motif) ligand 8Cartilage-1.540.042
373KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3Cartilage+1.540.026
374C1orf54chromosome 1 open reading frame 54Cartilage+1.530.006
375RBPMSRNA binding protein with multiple splicingCartilage-1.520.037
376NEDD9neural precursor cell expressed, developmentally down-regulated 9Cartilage-1.510.009
377EMP1epithelial membrane protein 1Cartilage-1.510.020
378CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Cartilage-1.470.023
379ETS2v-ets avian erythroblastosis virus E26 oncogene homolog 2Cartilage-1.470.032
380MCL1myeloid cell leukemia 1Cartilage-1.460.008
381MID1IP1MID1 interacting protein 1Cartilage-1.450.039
382HSPA1Aheat shock 70kDa protein 1ACartilage-1.440.007
383IL1R1interleukin 1 receptor, type ICartilage-1.430.040
384BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3Cartilage-1.430.041
385ARID5BAT rich interactive domain 5B (MRF1-like)Cartilage-1.430.021
386SPRY2sprouty homolog 2 (Drosophila)Cartilage-1.420.043
387BTG1B-cell translocation gene 1, anti-proliferativeCartilage-1.400.013
388CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Cartilage-1.400.041
389HNRNPA1heterogeneous nuclear ribonucleoprotein A1Cartilage-1.360.028
390CCDC59coiled-coil domain containing 59Cartilage-1.330.035
391BTG3BTG family, member 3Cartilage-1.290.048

Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

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Compounds for genes affiliated with Osteoarthritis

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Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1actinidin4410.3CTSL, CTSK
2rhodamine4410.3CTSL, CTSK
3scca14410.3CTSL, CTSK
4thermolysin4410.2MMP13, CTSL
5hydroxyproline44 25 1212.2MMP13, COL2A1, CTSL
6alginate4410.2COL2A1, MMP13
7aprotinin44 1211.1MMP13, CTSK, CTSL
8glycosaminoglycan4410.1COL2A1, MMP13, TNFAIP6
9sid 266815096010.0CTSL, CTSK, CTSV, CTSA
10n-acetyl-l-leucyl-l-leucyl-l-methional6010.0CTSK, CTSV, CTSA, CTSL
11chondroitin sulfate44 2511.0CTSL, CTSK, MMP13, TNFAIP6
12l 0062356010.0CTSK, CTSV, CTSA, CTSL
13e 64d44 6011.0CTSK, CTSV, CTSA, CTSL
14calpeptin44 6011.0CTSK, CTSV, CTSA, CTSL
15aspartate449.9CTSL, CTSK, COL2A1, ASPN
16phenylalanine449.8CTSL, CTSK, MMP13
171,10-phenanthroline44 310.8CTSL, CTSK
18cysteine449.5MMP13, COL2A1, CTSK, CTSV, CTSL
19serine449.4TNFAIP6, MMP13, COL2A1, CTSK, CTSA, CTSL

GO Terms for genes affiliated with Osteoarthritis

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Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.1CTSL, CTSK
2lysosomal lumenGO:0432029.8CTSL, CTSA, CTSV
3extracellular spaceGO:0056159.6CTSL, CTSK, COL2A1, MMP13, FRZB
4extracellular regionGO:0055769.1MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:03028210.1ASPN, MMP13
2proteolysis involved in cellular protein catabolic processGO:05160310.1CTSL, CTSK
3tissue homeostasisGO:00189410.1COL2A1, COL9A1
4collagen catabolic processGO:0305749.7MMP13, COL2A1, COL9A1, CTSK, CTSL
5proteolysisGO:0065089.6CTSL, CTSK, MMP13
6extracellular matrix disassemblyGO:0226179.5CTSL, CTSV, CTSK, COL9A1, COL2A1, MMP13
7extracellular matrix organizationGO:0301989.5MMP13, COL2A1, COL9A1, CTSK, CTSV, CTSL

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:00196810.1CTSL, CTSK
2extracellular matrix structural constituent conferring tensile strengthGO:03002010.1COL9A1, COL2A1
3cysteine-type endopeptidase activityGO:00419710.0CTSL, CTSV, CTSK
4cysteine-type peptidase activityGO:0082349.9CTSL, CTSV, CTSK
5collagen bindingGO:0055189.9ASPN, CTSK, CTSL
6proteoglycan bindingGO:0433949.8CTSL, CTSK

Products for genes affiliated with Osteoarthritis

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  • Antibodies
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  • Lysates
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Sources for Osteoarthritis

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27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet