MCID: OST012
MIFTS: 73

Osteoarthritis malady

Bone diseases category

Summaries for Osteoarthritis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoarthritis, also known as osteoarthrosis and allied disorder, is related to arthritis and rheumatoid arthritis. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs aspirin and chondroitin and the compounds chondroitin sulfate and sid 26681509 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotype limbs/digits/tail.

Disease Ontology:8 An arthritis that has material basis in worn out cartilage located in joint.

CDC:3 Osteoarthritis is a disease characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of osteoarthritis are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, and use of medications.

Wikipedia:63 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoarthritis 8 10 44 33 30
osteoarthrosis and allied disorder 8
degenerative joint disease 8
degenerative polyarthritis 60
degenerative arthritis 8
hypertrophic arthritis 8
osteoarthrosis 8


External Ids:

Disease Ontology8 DOID:8398
ICD9CM27 715.3

Related Diseases for Osteoarthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13
2rheumatoid arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13, ASPN
3osteoporosis30.7MMP13, CTSL, CTSK, COL2A1
4multiple epiphyseal dysplasia30.2COL9A1
5pseudoachondroplasia30.0COL9A1
6stickler syndrome29.9COL2A1, COL9A1
7osteochondritis dissecans29.9COL9A1
8giant cell tumor29.7CTSL, CTSK
9synovitis10.6
10obesity10.4
11psoriatic arthritis10.3
12spondylosis10.3
13arthropathy10.3
14cartilage disease10.3
15osteoporotic fracture10.2
16spinal stenosis10.2
17hypertension10.2
18reactive arthritis10.2
19spondyloarthropathy10.2
20bone fracture10.1
21gout10.1
22osteonecrosis10.1
23pseudogout10.1
24hemochromatosis10.1
25bursitis10.1
26loeys-dietz syndrome type 310.1
27osteoarthritis with mild chondrodysplasia10.1
28familial osteochondritis dissecans10.1
29ankylosing spondylitis10.1
30acromegaly10.1
31gastroduodenitis10.1
32cervicitis10.1
33osteochondrosis10.1
34spondylitis10.1
35ocular albinism10.1
36spondylolysis10.1
37kidney disease10.1
38pigmentation disease10.1
39x-linked disease10.1
40spondylolisthesis10.0
41diffuse idiopathic skeletal hyperostosis10.0
42spondyloepiphyseal dysplasia congenita10.0
43systemic lupus erythematosus10.0
44neuronitis10.0
45chondromalacia10.0
46enthesopathy10.0
47hyperostosis10.0
48lipoma10.0
49lupus erythematosus10.0
50stickler syndrome type 110.0

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Clinical Features for Osteoarthritis

About this section

Drugs & Therapeutics for Osteoarthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoarthritis

Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Search CenterWatch for Osteoarthritis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

About this section

Anatomical Context for Osteoarthritis

About this section
Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteoarthritis:

32
Bone, Testes, Skin, Bone marrow, T cells, Endothelial, Adipocyte, Skeletal muscle, Heart, Placenta, Prostate, Brain, Whole blood, B cells

FMA organs/tissues related to Osteoarthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Osteoarthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537111.2MMP13, FRZB, CTSK, COL9A1, COL2A1

Publications for Osteoarthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Osteoarthritis:

(show top 50)    (show all 1779)
idTitleAuthorsYear
1
Inflammation is more distinct in temporomandibular joint osteoarthritis compared to the knee joint. (24210930)
2014
2
Defining and mapping the person with osteoarthritis for population studies and public health. (24173433)
2014
3
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
4
Patient education, disease activity and physical function: can we be more targeted? A cross sectional study among people with rheumatoid arthritis, psoriatic arthritis and hand osteoarthritis. (24286444)
2013
5
The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis. (24363359)
2013
6
Changes in synovial fluid biochemical markers following arthroscopic surgery in patients with knee osteoarthritis. (22441960)
2013
7
Pain assessment in animal models of osteoarthritis. (24333346)
2013
8
Cartilage signal intensity on T1-weighted MRI: association with risk factors and measures of knee osteoarthritis. (24322833)
2013
9
The diagnostic performance of radiography for detection of osteoarthritis-associated features compared with MRI in hip joints with chronic pain. (23842574)
2013
10
Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety. (24164189)
2013
11
Increased cartilage volume after injection of hyaluronic acid in osteoarthritis knee patients who underwent high tibial osteotomy. (24162762)
2013
12
Viscosupplementation for osteoarthritis: a primer for primary care physicians. (24203348)
2013
13
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. (23578941)
2013
14
Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. (24257023)
2013
15
Effect of an ankle-foot orthosis on knee joint mechanics: A novel conservative treatment for knee osteoarthritis. (24327668)
2013
16
Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis. (23111710)
2013
17
Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis. (22416876)
2012
18
Evidence for the dysregulated expression of TWIST1, TGFI^1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients. (22820497)
2012
19
The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort. (23093849)
2012
20
Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis. (20464399)
2011
21
The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. (20482813)
2010
22
Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (19802674)
2009
23
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. (19565489)
2009
24
Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. (18438860)
2008
25
Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels. (19035482)
2008
26
A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis. (18597398)
2008
27
Genomic approaches to bone and joint diseases. Current status of genetic study of osteoarthritis]. (18245884)
2008
28
Glomus tumor masquerading for 22 years as osteoarthritis of the hip. (18491482)
2008
29
Treatment of osteoarthritis with anakinra. (17437664)
2007
30
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. (17968906)
2007
31
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. (17963167)
2007
32
Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis? (18056043)
2007
33
Measurement of advanced glycation endproducts in skin of patients with rheumatoid arthritis, osteoarthritis, and dialysis-related spondyloarthropathy using non-invasive methods. (17653550)
2007
34
Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. (16868970)
2006
35
Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. (17009253)
2006
36
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. (16877351)
2006
37
The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. (16359877)
2006
38
Study on the effect of sodium hyaluronate intra-articular injection on the treatment of knee osteoarthritis]. (15828478)
2005
39
Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis. (15940561)
2005
40
Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (15818669)
2005
41
Increased matrix concentrations of IGFBP-5 in cancellous bone in osteoarthritis. (15308529)
2004
42
Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. (15456329)
2004
43
Risk factors for osteoarthritis: genetics. (14698640)
2004
44
Cyclooxygenase-2 inhibitor treatment of older osteoarthritis patients. (14989043)
2003
45
Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins. (12867590)
2003
46
COX-2 specific inhibitors in the management of osteoarthritis of the knee: a placebo-controlled, randomized, double-blind study. (17039120)
2001
47
Neurotransmitter modulation of interleukin 6 (IL-6) and IL-8 secretion of synovial fibroblasts in patients with rheumatoid arthritis compared to osteoarthritis. (11093434)
2000
48
Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis. (9920023)
1999
49
Interleukin 8 in rheumatoid and osteoarthritis. (1570497)
1992
50
Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma. (4333902)
1972

Genetic Variations for Osteoarthritis

About this section

Expression for genes affiliated with Osteoarthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

About this section
Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Osteoarthritis

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1chondroitin sulfate44 2412.3MMP13, CTSL, CTSK, TNFAIP6
2sid 266815095911.2CTSL, CTSK, CTSA
3n-acetyl-l-leucyl-l-leucyl-l-methional5911.2CTSK, CTSA, CTSL
4l 0062355911.2CTSK, CTSA, CTSL
5e 64d44 5912.1CTSK, CTSA, CTSL
6calpeptin44 5912.1CTSK, CTSA, CTSL
7hydroxyproline44 11 2413.1MMP13, CTSL, COL2A1
8aprotinin44 1111.9CTSK, CTSL, MMP13
9rhodamine4410.9CTSL, CTSK
10actinidin4410.8CTSL, CTSK
11thermolysin4410.8MMP13, CTSL
12scca14410.7CTSL, CTSK
13glycosaminoglycan4410.6MMP13, TNFAIP6, COL2A1

GO Terms for genes affiliated with Osteoarthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.8CTSL, CTSK

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057411.2MMP13, CTSL, CTSK, COL9A1, COL2A1
2extracellular matrix disassemblyGO:02261711.1COL2A1, COL9A1, CTSK, CTSL, MMP13
3extracellular matrix organizationGO:03019810.9MMP13, CTSL, CTSK, COL9A1, COL2A1
4tissue homeostasisGO:00189410.8COL9A1, COL2A1

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:03002010.8COL9A1, COL2A1

Products for genes affiliated with Osteoarthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoarthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet