Osteoarthritis malady

MedlinePlus:³³ Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Osteoarthritis, also known as osteoarthrosis, is related to arthritis and rheumatoid arthritis, and has symptoms including autosomal dominant inheritance, autosomal recessive inheritance and heterogeneous. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Matrix Metalloproteinases. The drugs indomethacin and sulindac and the compounds actinidin and rhodamine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:⁹ An arthritis that has material basis in worn out cartilage located in joint.

CDC:⁴ Osteoarthritis (OA) is a disease of the entire joint involving the cartilage, joint lining, ligaments, and underlying bone. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of OA are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, use of medications, and eventually total joint replacement.

Wikipedia:⁶⁴ Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

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Disease Ontology9 DOID:8398 ICD9CM28 715.3

UMLS61 C0157946

HPO human phenotypes related to Osteoarthritis:

(show all 6)

id	Description	Frequency	HPO Source Accession
1	autosomal dominant inheritance		HP:0000006
2	autosomal recessive inheritance		HP:0000007
3	heterogeneous		HP:0001425
4	multifactorial inheritance		HP:0001426
5	abnormality of pelvic girdle bone morphology		HP:0002644
6	hip osteoarthritis		HP:0008843

Search GEO for disease gene expression data for Osteoarthritis.