MCID: OST012
MIFTS: 73

Osteoarthritis malady

Bone diseases category

Summaries for Osteoarthritis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Osteoarthritis is the most common form of arthritis. it causes pain, swelling, and reduced motion in your joints. it can occur in any joint, but usually it affects your hands, knees, hips or spine. osteoarthritis breaks down the cartilage in your joints. cartilage is the slippery tissue that covers the ends of bones in a joint. healthy cartilage absorbs the shock of movement. when you lose cartilage, your bones rub together. over time, this rubbing can permanently damage the joint. risk factors for osteoarthritis include being overweight getting older injuring a joint no single test can diagnose osteoarthritis. most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests. treatments include exercise, medicines, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoarthritis, also known as osteoarthrosis and allied disorder, is related to arthritis and rheumatoid arthritis. An important gene associated with Osteoarthritis is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs aspirin and chondroitin and the compounds chondroitin sulfate and sid 26681509 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related mouse phenotype limbs/digits/tail.

Disease Ontology:8 An arthritis that has material basis in worn out cartilage located in joint.

CDC:3 Osteoarthritis is a disease characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The breakdown of these tissues eventually leads to pain and joint stiffness. The joints most commonly affected are the knees, hips, and those in the hands and spine. The specific causes of osteoarthritis are unknown, but are believed to be a result of both mechanical and molecular events in the affected joint. Disease onset is gradual and usually begins after the age of 40. There is currently no cure for OA. Treatment for OA focuses on relieving symptoms and improving function, and can include a combination of patient education, physical therapy, weight control, and use of medications.

Wikipedia:63 Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or... more...

Aliases & Classifications for Osteoarthritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoarthritis 8 10 44 33 30
osteoarthrosis and allied disorder 8
degenerative joint disease 8
degenerative polyarthritis 60
degenerative arthritis 8
hypertrophic arthritis 8
osteoarthrosis 8


External Ids:

Disease Ontology8 DOID:8398
ICD9CM27 715.3

Related Diseases for Osteoarthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoarthritis family:

Osteoarthritis-5

Diseases related to Osteoarthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13
2rheumatoid arthritis31.4COL2A1, TNFAIP6, CTSK, CTSL, MMP13, ASPN
3osteoporosis30.7MMP13, CTSL, CTSK, COL2A1
4multiple epiphyseal dysplasia30.2COL9A1
5pseudoachondroplasia30.0COL9A1
6stickler syndrome29.9COL2A1, COL9A1
7osteochondritis dissecans29.9COL9A1
8giant cell tumor29.7CTSL, CTSK
9synovitis10.6
10obesity10.4
11psoriatic arthritis10.3
12spondylosis10.3
13arthropathy10.3
14cartilage disease10.3
15osteoporotic fracture10.2
16spinal stenosis10.2
17hypertension10.2
18reactive arthritis10.2
19spondyloarthropathy10.2
20bone fracture10.1
21gout10.1
22osteonecrosis10.1
23pseudogout10.1
24hemochromatosis10.1
25bursitis10.1
26loeys-dietz syndrome type 310.1
27osteoarthritis with mild chondrodysplasia10.1
28familial osteochondritis dissecans10.1
29ankylosing spondylitis10.1
30acromegaly10.1
31gastroduodenitis10.1
32cervicitis10.1
33osteochondrosis10.1
34spondylitis10.1
35ocular albinism10.1
36spondylolysis10.1
37kidney disease10.1
38pigmentation disease10.1
39x-linked disease10.1
40spondylolisthesis10.0
41diffuse idiopathic skeletal hyperostosis10.0
42spondyloepiphyseal dysplasia congenita10.0
43systemic lupus erythematosus10.0
44neuronitis10.0
45chondromalacia10.0
46enthesopathy10.0
47hyperostosis10.0
48lipoma10.0
49lupus erythematosus10.0
50stickler syndrome type 110.0

Graphical network of the top 20 diseases related to Osteoarthritis:



Diseases related to osteoarthritis

Clinical Features for Osteoarthritis

About this section

Drugs & Therapeutics for Osteoarthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoarthritis

Drug clinical trials:

Search ClinicalTrials for Osteoarthritis

Search NIH Clinical Center for Osteoarthritis

Search CenterWatch for Osteoarthritis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteoarthritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteoarthritis:
4D20.8 PureStem
Autologous adipose-derived mesenchymal stromal cells for the treatment of osteoarthritis
Autologous bone marrow-derived stem cells for the treatment of osteoarthritis
Autologous chondrocyte for severe hip osteoarthritis
Bone marrow-derived mesenchymal stem cells for osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived mesenchymal stem cells for knee osteoarthritis
Bone marrow-derived stem cells for knee osteoarthritis
Carticel
CARTISTEM
Chondrocell
Chondrogen
HiQCell
JACC
Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy
RNL-JointStem
StempeucelOA
Trinity
Embryonic/Adult Cultured Cells Related to Osteoarthritis:
PureStem, PMID: 22519755
Adipose-derived mesenchymal stromal cells, PMID: 23613363
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stem cells
Bone marrow-derived mesenchymal stromal cells
Bone marrow-derived mesenchymal stromal cells
Chondrocytes (Carticel
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells, PMIDs: 10102814, 14673997, 19530993, 12708651
Adipose-derived stromal vascular fraction and adipocytes (HiQCell), PMID: 22913454
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Bone marrow-derived mesenchymal stem cells, PMID: 22750747
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 22837175
Demineralized bone with osteoprogenitor and adult stem cells (Trinity, PMIDs: 21056860, 20508015

Genetic Tests for Osteoarthritis

About this section

Anatomical Context for Osteoarthritis

About this section
Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteoarthritis:

32
Bone, Testes, Skin, Bone marrow, T cells, Endothelial, Adipocyte, Skeletal muscle, Heart, Placenta, Prostate, Brain, Whole blood, B cells

FMA organs/tissues related to Osteoarthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Osteoarthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageZeugopod Articular CartilageArticular Cartilage Cells Affected by disease
2 CartilageAutopod Articular CartilageArticular Cartilage Cells Affected by disease
3 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
4 LimbZeugopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
5 LimbAutopod Synovial JointCentral Intermediate Lamina Cells Affected by disease
6 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate
8 BoneCervical Vertebrae  Affected by disease
9 BoneLumbar Vertebrae  Affected by disease
10 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Osteoarthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Osteoarthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537111.2MMP13, FRZB, CTSK, COL9A1, COL2A1

Publications for Osteoarthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Osteoarthritis:

(show top 50)    (show all 1779)
idTitleAuthorsYear
1
Disability and not osteoarthritis predicts cardiovascular disease: a prospective population-based cohort study. (24385204)
2014
2
Comparative outcomes and cost-utility after surgical treatment of focalA lumbar spinal stenosis compared with osteoarthritis of the hip orA knee-part 1: long-term change in health-related quality of life. (24325880)
2014
3
Distal femoral varus osteotomy combined with tibial plateau fresh osteochondral allograft for post-traumatic osteoarthritis of the knee. (24420606)
2014
4
NFATc1 and NFATc2 repress spontaneous osteoarthritis. (24248346)
2013
5
GPs don't offer exercise options to patients with osteoarthritis. (24191830)
2013
6
Prevalence of doctor-diagnosed thumb carpometacarpal joint osteoarthritis: Analysis of Swedish health care. (24339432)
2013
7
Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK). (23850552)
2013
8
Effects of a soft prefabricated thumb orthosis in carpometacarpal osteoarthritis. (24215554)
2013
9
Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus. (23831668)
2013
10
MDHAQ/RAPID3 to recognize improvement over 2 months in usual care of patients with osteoarthritis, systemic lupus erythematosus, spondyloarthropathy, and gout, as well as rheumatoid arthritis. (23669797)
2013
11
Self-management approaches for osteoarthritis in the hand: a 2x2 factorial randomised trial. (24107979)
2013
12
Is osteoarthritis a metabolic disease? (24176735)
2013
13
Longitudinal (1-year) change in cartilage thickness in knees with early knee osteoarthritis: A within-person between-knee comparison-data from the OAI. (24106150)
2013
14
Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis. (24329488)
2013
15
CORR Insights Ar: Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. (24014268)
2013
16
Analysis of estrogen receptor alpha gene haplotype in Mexican mestizo patients with primary osteoarthritis of the knee. (21445546)
2012
17
Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models. (22933232)
2012
18
Pathologic and pathogenic processes in osteoarthritis: the effects of synovitis. (23372521)
2012
19
Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. (22294259)
2012
20
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. (20724312)
2011
21
Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. (21199727)
2010
22
Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis. (20131243)
2010
23
Expression of MicroRNA-146a in osteoarthritis cartilage. (19333945)
2009
24
Modulating hedgehog signaling can attenuate the severity of osteoarthritis. (19915594)
2009
25
Confirmation of two major polyarticular osteoarthritis (POA) phenotypes--differentiation on the basis of joint topography. (19264516)
2009
26
Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature. (18226555)
2008
27
Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. (17593496)
2007
28
EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). (17046965)
2007
29
The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. (17284543)
2007
30
Replication of association of the D-repeat polymorphism in asporin with osteoarthritis. (16834761)
2006
31
Diagnostic discordance: we cannot agree when to call knee pain 'osteoarthritis'. (15640301)
2005
32
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. (16052547)
2005
33
Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis. (16082648)
2005
34
Intra-articular therapy with autologous interleukin-1 receptor antagonist in osteoarthritis. Innovation or quackery?]. (15517132)
2004
35
Childhood-onset osteoarthritis, tall stature, and sensorineural hearing loss associated with Arg75-Cys mutation in procollagen type II gene (COL2A1). (15593085)
2004
36
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction. (15535829)
2004
37
Pathophysiology and first-line treatment of osteoarthritis. (11918520)
2002
38
Possible causes of acute pseudogout in older patients with osteoarthritis. (10991746)
2000
39
Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M. (10632674)
2000
40
Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis. (10451709)
1999
41
Autosomal dominant hypoparathyroidism associated with short stature and premature osteoarthritis. (10487661)
1999
42
Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study. (9849311)
1998
43
Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts. (9616438)
1998
44
Meloxicam in osteoarthritis: a 6-month, double-blind comparison with diclofenac sodium. (8630635)
1996
45
Hereditary arthro-ophthalmopathy (Stickler syndrome): a diagnosis to consider in familial premature osteoarthritis. (8000751)
1994
46
Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis. (7986224)
1994
47
The role of phospholipase A2 in the physiopathology of osteoarthritis. (2027108)
1991
48
Cathepsin B and cysteine protease inhibitors in human osteoarthritis. (2324852)
1990
49
Acid hydrolases in the articular cartilage of the patella. Normal, chondromalacia patellae and osteoarthritis. (4825716)
1974
50
Vertebral artery insufficiency secondary to trauma and osteoarthritis of the cervical spine. (5957375)
1966

Genetic Variations for Osteoarthritis

About this section

Expression for genes affiliated with Osteoarthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoarthritis

Search GEO for disease gene expression data for Osteoarthritis.

Pathways for genes affiliated with Osteoarthritis

About this section
Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Osteoarthritis

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Osteoarthritis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1chondroitin sulfate44 2412.3MMP13, CTSL, CTSK, TNFAIP6
2sid 266815095911.2CTSL, CTSK, CTSA
3n-acetyl-l-leucyl-l-leucyl-l-methional5911.2CTSK, CTSA, CTSL
4l 0062355911.2CTSK, CTSA, CTSL
5e 64d44 5912.1CTSK, CTSA, CTSL
6calpeptin44 5912.1CTSK, CTSA, CTSL
7hydroxyproline44 11 2413.1MMP13, CTSL, COL2A1
8aprotinin44 1111.9CTSK, CTSL, MMP13
9rhodamine4410.9CTSL, CTSK
10actinidin4410.8CTSL, CTSK
11thermolysin4410.8MMP13, CTSL
12scca14410.7CTSL, CTSK
13glycosaminoglycan4410.6MMP13, TNFAIP6, COL2A1

GO Terms for genes affiliated with Osteoarthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.8CTSL, CTSK

Biological processes related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057411.2MMP13, CTSL, CTSK, COL9A1, COL2A1
2extracellular matrix disassemblyGO:02261711.1COL2A1, COL9A1, CTSK, CTSL, MMP13
3extracellular matrix organizationGO:03019810.9MMP13, CTSL, CTSK, COL9A1, COL2A1
4tissue homeostasisGO:00189410.8COL9A1, COL2A1

Molecular functions related to Osteoarthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:03002010.8COL9A1, COL2A1

Products for genes affiliated with Osteoarthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoarthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet