MCID: OST006
MIFTS: 44

Osteoblastoma malady

Bone diseases, Cancer diseases, Rare diseases categories

Summaries for Osteoblastoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the bone. more...

MalaCards: Osteoblastoma is related to osteosarcoma and giant cell tumor. An important gene associated with Osteoblastoma is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways are EGFR Signaling Pathway and Cytoskeleton remodeling Keratin filaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and spinal cord, and related mouse phenotype vision/eye.

Aliases & Classifications for Osteoblastoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

osteoblastoma 9 11 46 50 63


External Ids:

Disease Ontology9 DOID:0060098
MESH via Orphanet37 D018215
SNOMED-CT via Orphanet60 55333008
UMLS via Orphanet64 C0029417

Related Diseases for Osteoblastoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.9SPARC, TP53, MT-CO2
2giant cell tumor30.4VIM, MUC1
3sarcoma30.3TP53, VIM, MUC1
4hemangiopericytoma29.9VIM, MUC1
5meningioma29.9SPARC, VIM, MUC1
6cervicitis10.6
7periostitis10.5
8aneurysmal bone cysts10.4
9aneurysm10.4
10osteomalacia10.2
11osteofibrous dysplasia10.1SPARC
12choroid plexus papilloma10.1TP53
13thyroiditis10.1
14osteochondroma10.1
15back pain10.1
16sinusitis10.1
17eccrine porocarcinoma10.1MUC1
18hidradenoma10.1MUC1
19syringoma10.1MUC1
20cystadenocarcinoma10.1MUC1
21adenomatoid tumor10.1VIM
22glomus tumor10.1VIM
23cataract10.0SPARC
24endometrial carcinoma10.0MUC1, TP53
25cholangiocarcinoma10.0MUC1, TP53
26clear cell ependymoma10.0MUC1, VIM
27spindle cell carcinoma10.0MUC1, VIM
28spindle cell sarcoma10.0VIM, MUC1
29epithelioid sarcoma10.0VIM, MUC1
30sertoli cell tumor10.0VIM, MUC1
31dermatofibrosarcoma protuberans10.0VIM, MUC1
32secretory meningioma10.0VIM, MUC1
33rhabdoid tumor10.0VIM, MUC1
34perineurioma10.0VIM, MUC1
35sex cord-gonadal stromal tumor10.0VIM, MUC1
36chordoma10.0MUC1, VIM
37angiosarcoma10.0MUC1, VIM
38malignant peripheral nerve sheath tumor10.0VIM, MUC1
39abrikosov's tumor10.0VIM, MUC1
40neurofibroma10.0VIM, MUC1
41pleomorphic adenoma10.0VIM, MUC1
42carcinoid syndrome10.0SPARC, MUC1
43adenoid cystic carcinoma10.0VIM, MUC1
44ependymoma10.0MUC1, VIM
45stomach cancer10.0SPARC, TP53, MUC1
46oxyphilic adenoma10.0MUC1, VIM
47liposarcoma10.0TP53, VIM
48peripheral primitive neuroectodermal tumor10.0SPARC, VIM
49synovial sarcoma10.0VIM, MUC1
50renal clear cell carcinoma10.0MUC1, VIM

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to osteoblastoma

Symptoms for Osteoblastoma

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Drugs & Therapeutics for Osteoblastoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Osteoblastoma

Drug clinical trials:

Search ClinicalTrials for Osteoblastoma

Search NIH Clinical Center for Osteoblastoma

Search CenterWatch for Osteoblastoma

Genetic Tests for Osteoblastoma

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Anatomical Context for Osteoblastoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Osteoblastoma:

34
Bone, Thyroid, Spinal cord, Bone marrow, Pineal

Animal Models for Osteoblastoma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Osteoblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5MUC1, VIM, TP53, SPARC

Publications for Osteoblastoma

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Sources:
53PubMed
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Articles related to Osteoblastoma:

(show top 50)    (show all 472)
idTitleAuthorsYear
1
Osteoblastoma Is a Metabolically Active Benign Bone Tumor on 18F-FDG PET Imaging. (24144518)
2013
2
Frontal sinus osteoma with osteoblastoma-like histology and associated intracranial pneumatocele. (22274656)
2012
3
Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. (22870593)
2012
4
Osteoblastoma of the inferior turbinate. (21493259)
2011
5
Osteoblastoma of the sternum--case report and review of the literature. (20345366)
2010
6
Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature. (21412027)
2010
7
Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. (19963118)
2009
8
Concurrent osteochondroma and osteoblastoma of the proximal humeral shaft. (19226029)
2009
9
Osteoblastoma of the temporal bone. (20190944)
2009
10
Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases. (19589324)
2009
11
Pathology quiz case 2. Osteoblastoma. (19451478)
2009
12
Osteoblastoma in the skeletally immature. (18580372)
2008
13
Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. (17641905)
2008
14
Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. (19050575)
2008
15
Osteoblastoma crossing the sacro-iliac joint. (16552607)
2007
16
Progression of a lumbar spinal osteoblastoma. (16041187)
2005
17
Osteoblastoma of the larynx: a case report. (16273197)
2005
18
A rare case of periosteal osteoblastoma located in the frontal cranial bone. (15913430)
2005
19
Radiation therapy for sacral osteoblastoma. (12708718)
2003
20
"Occult" roentgenographic osteoblastoma of the cervical spine. (14508414)
2003
21
Osteoblastoma of transverse process of 8th dorsal vertebra. (12696737)
2002
22
Osteoblastoma-like osteosarcoma. (11201036)
2000
23
Recurrent osteoblastoma of the hamate bone. A two-stage reconstruction with a free vascularized iliac crest flap. (10473168)
1999
24
Recurrent osteoblastoma of the hamate bone. (10672826)
1999
25
Benign osteoblastoma of the odontoid process of the axis: a case report. (9508114)
1998
26
Osteoid osteoma and osteoblastoma: MRI appearances and the significance of ring enhancement. (8797998)
1996
27
Osteoblastoma in the anterior maxilla mimicking periapical pathosis of odontogenic origin. (8618097)
1996
28
Osteoid osteoma or osteoblastoma of the cervical spine in relation to the vertebral artery. (7814596)
1994
29
Osteoblastoma: clinicopathologic study of 306 cases. (8119712)
1994
30
Massive benign osteoblastoma of the clivus and atlas. (7811416)
1994
31
Acquired vitamin D-resistant rickets caused by aggressive osteoblastoma in the pelvis: a case report with ten years' follow-up and review of the literature. (7814597)
1994
32
Bone scan appearances of a metastasizing aggressive osteoblastoma. A case report. (8344025)
1993
33
Osteoblastoma-like osteosarcoma. The Rizzoli Institute experience. (8302813)
1993
34
A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case. (8478388)
1993
35
Recurrent benign osteoblastoma of the parietal bone. (2631721)
1989
36
Spinal osteoblastoma in an 11-year-old boy. (3393954)
1988
37
Rib osteoblastoma: a clinical manifestation. (3406842)
1988
38
Scoliosis secondary to osteoblastoma of the rib. (3624472)
1987
39
Benign osteoblastoma of the clivus removed by a transoral approach: case report. (3808275)
1987
40
Radical excision of an osteoblastoma of the cervical spine. A combined anterior and posterior approach. (3958022)
1986
41
Can an osteoblastoma become malignant? (3936268)
1985
42
Benign osteoblastoma of the maxillary sinus. (6665425)
1983
43
An unusual case of osteoblastoma of the femur. (6885392)
1983
44
Collagen and noncollagen protein synthesis in chick limb bud cells infected with a virus that causes osteoblastoma. (7289876)
1981
45
Benign osteoblastoma of the jaws: report of three cases. (6931893)
1980
46
The spectrum of osteoblastoma. (175701)
1976
47
Benign osteoblastoma. (1054453)
1975
48
Osteoid osteoma--osteoblastoma. (4819213)
1974
49
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
50
Benign osteoblastoma. (4657814)
1972

Variations for Osteoblastoma

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Expression for genes affiliated with Osteoblastoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for genes affiliated with Osteoblastoma

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Sources:
51PathCards, 58SinoBiological, 61Thomson Reuters, 13EMD Millipore, 39NCBI BioSystems Database
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Pathways related to Osteoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MUC1, TP53
29.5VIM, TUBA1C
3
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.5VIM, TUBA1C
49.3TP53, SPARC

Compounds for genes affiliated with Osteoblastoma

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Sources:
46Novoseek, 3BitterDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Osteoblastoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1eosin4610.0MUC1, VIM
2s 1004610.0MUC1, VIM
3reticulin4610.0MUC1, VIM
4mucicarmine4610.0MUC1, VIM
5b 723469.9MUC1, VIM
6aristolochic acid46 310.9TP53, VIM
7temozolomide46 1210.9VIM, TP53
8crcs469.9TP53, MUC1
9hematoxylin469.9VIM, MUC1
10n-(4-hydroxyphenyl)retinamide469.8VIM, TP53
11roscovitine469.8TP53, VIM
12titanium469.7SPARC, VIM
13vinblastine46 52 1211.7VIM, TP53
14progestin469.7VIM, MUC1
15colchicine46 62 3 30 1213.6VIM, TUBA1C
16hydroxyapatite469.6VIM, SPARC
17procollagen469.6SPARC, VIM
18chondroitin sulfate46 2510.5VIM, SPARC
19cytarabine46 52 1211.5TP53, VIM, MUC1
20adriamycin469.5MUC1, VIM, TP53
21gemcitabine46 52 1211.4TP53, MUC1
22tamoxifen46 52 30 1212.4MUC1, VIM, TP53
23actinomycin d469.4MUC1, VIM, TP53
24lactate469.3MT-CO2, VIM, SPARC
25sb 20358046 6210.2VIM, TP53, SPARC
26paclitaxel46 52 1211.2VIM, TP53, SPARC
27nocodazole46 1210.2TP53, VIM
28proline469.2SPARC, TP53, VIM
29thymidine46 2510.2MUC1, TP53, SPARC
30testosterone46 62 25 1212.0MUC1, VIM, SPARC
31butyrate468.9MUC1, VIM, TP53, SPARC
32paraffin468.9SPARC, TP53, VIM, MUC1
33oligonucleotide468.9VIM, TP53, SPARC
34progesterone46 30 62 25 1212.9SPARC, TP53, VIM, MUC1
35vegf468.9SPARC, TP53, VIM, MUC1
36estrogen468.8SPARC, TP53, VIM, MUC1
37retinoic acid46 259.8SPARC, TP53, VIM, MUC1

GO Terms for genes affiliated with Osteoblastoma

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17Gene Ontology
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Cellular components related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.5MUC1, TP53

Biological processes related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.5MUC1, TP53
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.2MUC1, TP53

Molecular functions related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00520010.0TUBA1C
2p53 bindingGO:0020399.2MUC1, TP53

Products for genes affiliated with Osteoblastoma

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Sources for Osteoblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet