MCID: OST006
MIFTS: 44

Osteoblastoma malady

Bone diseases, Cancer diseases, Rare diseases categories
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Summaries for Osteoblastoma

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Wikipedia:65 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the bone. more...

MalaCards based summary: Osteoblastoma is related to osteosarcoma and giant cell tumor. An important gene associated with Osteoblastoma is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways are EGFR Signaling Pathway and Cytoskeleton remodeling Keratin filaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and bone marrow, and related mouse phenotype vision/eye.

Aliases & Classifications for Osteoblastoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 63UMLS via Orphanet, 35MESH via Orphanet
See all sources

Osteoblastoma, Aliases & Descriptions:

Name: Osteoblastoma 8 10 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:0060098
UMLS via Orphanet63 C0029417
MESH via Orphanet35 D018215

Related Diseases for Osteoblastoma

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Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma31.0SPARC, TP53, MT-CO2
2giant cell tumor30.5VIM, MUC1
3sarcoma30.1TP53, VIM, MUC1
4hemangiopericytoma30.0VIM, MUC1
5meningioma29.8SPARC, VIM, MUC1
6cervicitis10.6
7periostitis10.5
8osteofibrous dysplasia10.5SPARC
9aneurysmal bone cysts10.5
10aneurysm10.5
11choroid plexus papilloma10.4TP53
12eccrine porocarcinoma10.4MUC1
13hidradenoma10.4MUC1
14syringoma10.4MUC1
15cystadenocarcinoma10.4MUC1
16adenomatoid tumor10.3VIM
17paraganglioma10.3VIM
18osteomalacia10.2
19back pain10.2
20cataract10.2SPARC
21endometrial carcinoma10.2MUC1, TP53
22sinusitis10.1
23ameloblastoma10.1
24thyroiditis10.1
25osteochondroma10.1
26cholangiocarcinoma10.1MUC1, TP53
27clear cell ependymoma10.1MUC1, VIM
28spindle cell carcinoma10.1MUC1, VIM
29spindle cell sarcoma10.1VIM, MUC1
30epithelioid sarcoma10.1VIM, MUC1
31sertoli cell tumor10.1VIM, MUC1
32dermatofibrosarcoma protuberans10.1VIM, MUC1
33secretory meningioma10.1VIM, MUC1
34rhabdoid tumor10.1VIM, MUC1
35perineurioma10.1VIM, MUC1
36sex cord-gonadal stromal tumor10.1VIM, MUC1
37chordoma10.1MUC1, VIM
38angiosarcoma10.1MUC1, VIM
39malignant peripheral nerve sheath tumor10.0VIM, MUC1
40abrikosov's tumor10.0VIM, MUC1
41neurofibroma10.0VIM, MUC1
42pleomorphic adenoma10.0VIM, MUC1
43carcinoid syndrome10.0SPARC, MUC1
44salivary gland adenoid cystic carcinoma10.0VIM, MUC1
45ependymoma10.0MUC1, VIM
46stomach cancer10.0SPARC, TP53, MUC1
47oxyphilic adenoma10.0MUC1, VIM
48liposarcoma10.0TP53, VIM
49peripheral primitive neuroectodermal tumor10.0SPARC, VIM
50synovial sarcoma10.0VIM, MUC1

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to osteoblastoma

Symptoms for Osteoblastoma

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Drugs & Therapeutics for Osteoblastoma

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Drug clinical trials:

Search ClinicalTrials for Osteoblastoma

Search NIH Clinical Center for Osteoblastoma

Genetic Tests for Osteoblastoma

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Anatomical Context for Osteoblastoma

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MalaCards organs/tissues related to Osteoblastoma:

32
Bone, Thyroid, Bone marrow, Spinal cord, Pineal

Animal Models for Osteoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Osteoblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5MUC1, VIM, TP53, SPARC

Publications for Osteoblastoma

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Articles related to Osteoblastoma:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Cervical osteoid osteoma progression to osteoblastoma. (24445325)
2014
2
I^-catenin is a valuable marker for differential diagnosis of osteoblastoma and osteosarcoma. (24746516)
2014
3
Osteoblastoma Is a Metabolically Active Benign Bone Tumor on 18F-FDG PET Imaging. (24144518)
2013
4
Osteoblastoma of the inferior turbinate. (21493259)
2011
5
Osteoblastoma of the sternum--case report and review of the literature. (20345366)
2010
6
Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature. (21412027)
2010
7
Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. (19963118)
2009
8
Concurrent osteochondroma and osteoblastoma of the proximal humeral shaft. (19226029)
2009
9
Osteoblastoma of the temporal bone. (20190944)
2009
10
Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases. (19589324)
2009
11
Pathology quiz case 2. Osteoblastoma. (19451478)
2009
12
Osteoblastoma in the skeletally immature. (18580372)
2008
13
Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. (17641905)
2008
14
Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. (19050575)
2008
15
Osteoblastoma crossing the sacro-iliac joint. (16552607)
2007
16
Progression of a lumbar spinal osteoblastoma. (16041187)
2005
17
Osteoblastoma of the larynx: a case report. (16273197)
2005
18
A rare case of periosteal osteoblastoma located in the frontal cranial bone. (15913430)
2005
19
Radiation therapy for sacral osteoblastoma. (12708718)
2003
20
"Occult" roentgenographic osteoblastoma of the cervical spine. (14508414)
2003
21
Osteoblastoma of transverse process of 8th dorsal vertebra. (12696737)
2002
22
Osteoblastoma-like osteosarcoma. (11201036)
2000
23
Recurrent osteoblastoma of the hamate bone. A two-stage reconstruction with a free vascularized iliac crest flap. (10473168)
1999
24
Recurrent osteoblastoma of the hamate bone. (10672826)
1999
25
Benign osteoblastoma of the odontoid process of the axis: a case report. (9508114)
1998
26
Osteoid osteoma and osteoblastoma: MRI appearances and the significance of ring enhancement. (8797998)
1996
27
Osteoblastoma in the anterior maxilla mimicking periapical pathosis of odontogenic origin. (8618097)
1996
28
Osteoid osteoma or osteoblastoma of the cervical spine in relation to the vertebral artery. (7814596)
1994
29
Osteoblastoma: clinicopathologic study of 306 cases. (8119712)
1994
30
Massive benign osteoblastoma of the clivus and atlas. (7811416)
1994
31
Acquired vitamin D-resistant rickets caused by aggressive osteoblastoma in the pelvis: a case report with ten years' follow-up and review of the literature. (7814597)
1994
32
Imaging features of maxillary osteoblastoma and its malignant transformation. (7824976)
1994
33
Bone scan appearances of a metastasizing aggressive osteoblastoma. A case report. (8344025)
1993
34
Osteoblastoma-like osteosarcoma. The Rizzoli Institute experience. (8302813)
1993
35
A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case. (8478388)
1993
36
Recurrent benign osteoblastoma of the parietal bone. (2631721)
1989
37
Spinal osteoblastoma in an 11-year-old boy. (3393954)
1988
38
Rib osteoblastoma: a clinical manifestation. (3406842)
1988
39
Scoliosis secondary to osteoblastoma of the rib. (3624472)
1987
40
Benign osteoblastoma of the clivus removed by a transoral approach: case report. (3808275)
1987
41
Radical excision of an osteoblastoma of the cervical spine. A combined anterior and posterior approach. (3958022)
1986
42
Can an osteoblastoma become malignant? (3936268)
1985
43
Benign osteoblastoma of the maxillary sinus. (6665425)
1983
44
An unusual case of osteoblastoma of the femur. (6885392)
1983
45
Collagen and noncollagen protein synthesis in chick limb bud cells infected with a virus that causes osteoblastoma. (7289876)
1981
46
Benign osteoblastoma of the jaws: report of three cases. (6931893)
1980
47
The spectrum of osteoblastoma. (175701)
1976
48
Benign osteoblastoma. (1054453)
1975
49
Osteoid osteoma--osteoblastoma. (4819213)
1974
50
Benign osteoblastoma. (4657814)
1972

Variations for Osteoblastoma

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Expression for genes affiliated with Osteoblastoma

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Expression patterns in normal tissues for genes affiliated with Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for genes affiliated with Osteoblastoma

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Pathways related to Osteoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MUC1, TP53
29.5VIM, TUBA1C
3
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.5VIM, TUBA1C
49.3TP53, SPARC

Compounds for genes affiliated with Osteoblastoma

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Compounds related to Osteoblastoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1eosin4410.0MUC1, VIM
2s 1004410.0MUC1, VIM
3reticulin4410.0MUC1, VIM
4mucicarmine4410.0MUC1, VIM
5b 723449.9MUC1, VIM
6aristolochic acid44 210.9TP53, VIM
7temozolomide44 1110.9VIM, TP53
8crcs449.9TP53, MUC1
9hematoxylin449.9VIM, MUC1
10n-(4-hydroxyphenyl)retinamide449.8VIM, TP53
11roscovitine449.8TP53, VIM
12titanium449.7SPARC, VIM
13vinblastine44 50 1111.7VIM, TP53
14progestin449.7VIM, MUC1
15colchicine44 61 2 28 1113.6VIM, TUBA1C
16hydroxyapatite449.6VIM, SPARC
17procollagen449.6SPARC, VIM
18chondroitin sulfate44 2410.5VIM, SPARC
19cytarabine44 50 1111.5TP53, VIM, MUC1
20adriamycin449.5MUC1, VIM, TP53
21gemcitabine44 50 1111.4TP53, MUC1
22tamoxifen44 50 28 1112.4MUC1, VIM, TP53
23actinomycin d449.4MUC1, VIM, TP53
24lactate449.3MT-CO2, VIM, SPARC
25sb 20358044 6110.2VIM, TP53, SPARC
26paclitaxel44 50 1111.2VIM, TP53, SPARC
27nocodazole44 1110.2TP53, VIM
28proline449.2SPARC, TP53, VIM
29thymidine44 2410.2MUC1, TP53, SPARC
30testosterone44 61 24 1112.0MUC1, VIM, SPARC
31butyrate448.9MUC1, VIM, TP53, SPARC
32paraffin448.9SPARC, TP53, VIM, MUC1
33oligonucleotide448.9VIM, TP53, SPARC
34progesterone44 28 61 24 1112.9SPARC, TP53, VIM, MUC1
35vegf448.9SPARC, TP53, VIM, MUC1
36estrogen448.8SPARC, TP53, VIM, MUC1
37retinoic acid44 249.8SPARC, TP53, VIM, MUC1

GO Terms for genes affiliated with Osteoblastoma

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Cellular components related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.5MUC1, TP53

Biological processes related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.5MUC1, TP53
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.2MUC1, TP53

Molecular functions related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00520010.0TUBA1C
2p53 bindingGO:0020399.2MUC1, TP53

Products for genes affiliated with Osteoblastoma

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  • Antibodies
  • Proteins
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Sources for Osteoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet