MCID: OST006
MIFTS: 31

Osteoblastoma malady

Categories: Bone diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Osteoblastoma

Summaries for Osteoblastoma

MalaCards based summary : Osteoblastoma is related to cervicitis and periostitis. An important gene associated with Osteoblastoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways is Signaling in Gap Junctions. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and craniofacial

Wikipedia : 71 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the... more...

Related Diseases for Osteoblastoma

Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 cervicitis 10.2
2 periostitis 10.1
3 aneurysmal bone cysts 10.1
4 aneurysm 10.1
5 scoliosis 10.1
6 male urethral cancer 10.0 CTNNB1 ZNRF3
7 sarcoma 9.9
8 giant cell tumor 9.9
9 back pain 9.9
10 thyroiditis 9.8
11 osteomalacia 9.8
12 thoracic benign neoplasm 9.8 ADCY1 SPARC ZNF133
13 osteochondroma 9.7
14 sinusitis 9.7
15 ameloblastoma 9.7
16 idiopathic scoliosis 9.7
17 mastoiditis 9.7
18 frontal sinusitis 9.6
19 calcifying epithelial odontogenic tumor 9.6
20 fibromatosis 9.6
21 facial paralysis 9.6
22 hemangioendothelioma 9.6
23 root resorption 9.6
24 lymphangiomatosis 9.6
25 klippel-trenaunay-weber syndrome 9.6
26 personality disorder 9.6
27 ossifying fibroma 9.6
28 weber syndrome 9.6
29 joint disorders 9.6
30 gaucher's disease 9.6
31 fibroma 9.6
32 exostosis 9.6
33 headache 9.6
34 hypoxia 9.6
35 laryngitis 9.6
36 spasticity 9.6
37 plasmacytoma 9.6
38 fibrous dysplasia 9.6
39 exophthalmos 9.6
40 rickets 9.6
41 adolescent idiopathic scoliosis 9.6
42 cerebellar medulloblastoma 8.7 ADCY1 CER1 CTNNB1 NELL1 SPARC TUBB2A

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to Osteoblastoma

Symptoms & Phenotypes for Osteoblastoma

GenomeRNAi Phenotypes related to Osteoblastoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 NELL1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.36 CTNNB1 NELL1 SPARC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.36 CTNNB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.36 NELL1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.36 NELL1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.36 SPARC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NELL1 SPARC
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.36 NELL1

MGI Mouse Phenotypes related to Osteoblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 8.92 CER1 CTNNB1 NELL1 SPARC

Drugs & Therapeutics for Osteoblastoma

Search Clinical Trials , NIH Clinical Center for Osteoblastoma

Genetic Tests for Osteoblastoma

Anatomical Context for Osteoblastoma

MalaCards organs/tissues related to Osteoblastoma:

39
Bone, Thyroid, Bone Marrow, Spinal Cord, Pineal

Publications for Osteoblastoma

Articles related to Osteoblastoma:

(show top 50) (show all 539)
id Title Authors Year
1
Spinal osteoid osteoma progressed to osteoblastoma with paraspinal soft tissue mass: a unique presentation. ( 27999873 )
2017
2
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
3
Aggressive osteoblastoma of the cervical spine involving the canal and vertebral artery: a case report. ( 27981453 )
2016
4
Epithelioid osteoblastoma of maxilla: A rare and aggressive variant of a benign neoplasm at an uncommon site. ( 27601840 )
2016
5
Removal of osteoblastoma of the talar neck using standard anterior ankle Arthroscopyi19A case report. ( 27100951 )
2016
6
Non Aggressive Mandibular Osteoblastoma- A Rare Maxillofacial Entity. ( 27190965 )
2016
7
Hypoxia-related microRNA-210 is a diagnostic marker for discriminating osteoblastoma and osteosarcoma. ( 27324965 )
2016
8
Aggressive osteoblastoma of the temporal bone: an unusual cause of facial palsy. ( 26923829 )
2016
9
Orbital Osteoblastoma: Technical Innovations in Resection and Reconstruction Using Virtual Surgery Simulation. ( 27516847 )
2016
10
Dorsal spine osteoblastoma. ( 27057242 )
2016
11
Agressive osteoblastoma in a seven-year-old girl's mandible: Treatment and six-year monitoring. ( 27518431 )
2016
12
Malignant transformation of aggressive osteoblastoma to ostesarcoma. ( 27499324 )
2016
13
Osteoid osteoma of the temporal bone manifesting as first bite syndrome and a meta-analysis combined with osteoblastoma. ( 27106094 )
2016
14
Osteoblastoma of the temporal articular tubercle misdiagnosed asA a temporomandibular joint disorder. ( 28043747 )
2016
15
Osteoblastoma of the thyroid cartilage. ( 27206395 )
2016
16
The effect of simple local resection on pain and scoliotic curve in patients with scoliosis secondary to osteoid osteoma and osteoblastoma in the spine. ( 27130390 )
2016
17
Malignant transformation of a high-grade osteoblastoma of the petrous apex with subcutaneous metastasis. ( 27304442 )
2016
18
Unusual presentation of osteoblastoma as vertebra plana - a case report and review of literature. ( 27664343 )
2016
19
Surgical resection of osteoid osteoma and osteoblastoma of the spine. ( 27832013 )
2016
20
Clinical management of a challenging malignancy, osteoblastoma-like osteosarcoma: a report of four cases and a review of the literature. ( 27574436 )
2016
21
Bilateral C-1 lateral mass reconstruction following radical resection of a giant osteoblastoma of the atlas: case report. ( 27834626 )
2016
22
Osteoblastoma of the thoracic spine presenting with back pain. ( 26792200 )
2016
23
Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature. ( 27400109 )
2016
24
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos. ( 26895762 )
2016
25
Osteoblastoma originating from frontoethmoidal sinus causing personality disorders and superior gaze palsy. ( 26755236 )
2016
26
Anterior Reconstruction of C2-C3 Bodies in a 6-Year-Old Patient with a Huge Osteoblastoma: A Novel Technique. ( 26835212 )
2016
27
Surgical management of an osteoblastoma involving the entire C2 vertebra and a review of literature. ( 26879919 )
2016
28
CT-Guided Percutaneous Cryoablation of an Aggressive Osteoblastoma: A Case Report. ( 26505944 )
2015
29
Benign osteoblastoma of cervical spine. ( 26096485 )
2015
30
Surgical treatment options for aggressive osteoblastoma in the mobile spine. ( 25847727 )
2015
31
Intercostal neuralgia as a symptom of an osteoblastoma in thoracic spine. ( 26139654 )
2015
32
Cutaneous epithelioid osteoblastoma. ( 25803726 )
2015
33
Periosteal osteoblastoma of the pelvis: a rare case. ( 25648425 )
2015
34
Sino-Orbital Osteoma With Osteoblastoma-Like Features. ( 25663319 )
2015
35
Clinical characteristics and diagnostic imaging of cranial osteoblastoma. ( 25595957 )
2015
36
A case report of osteoblastoma on the distal phalanx of the ring finger successfully treated with curettage and polymethylmethacrylate filling. ( 26072004 )
2015
37
A rare case of osteoblastoma associated to aneurysmal bone cyst of the spine. Case report. ( 26204456 )
2015
38
Epithelioid Multinodular Osteoblastoma of the Mandible: A Case Report and Review of Literature. ( 26507845 )
2015
39
Osteoblastoma of the coracoid process: an unusual location. ( 26420699 )
2015
40
Psammous desmo-osteoblastoma with concomitant aneurysmal bone cyst of mandible. ( 26389053 )
2015
41
An unusual presentation of pediatric osteoblastoma in a patient with Klippel-Trenaunay-Weber syndrome: case report. ( 26030331 )
2015
42
Destructive osteoblastoma with secondary aneurysmal bone cyst of cervical vertebra in an 11-year-old boy: case report. ( 24482719 )
2014
43
Cervical osteoblastoma resection and posterior fusion. ( 24549390 )
2014
44
Aggressive multilocular osteoblastoma in the mandible: a rare and difficult case to diagnose. ( 25517784 )
2014
45
Unusual cause of back pain in a 13-year-old boy: a thoracic osteoblastoma. ( 24851081 )
2014
46
I^-catenin is a valuable marker for differential diagnosis of osteoblastoma and osteosarcoma. ( 24746516 )
2014
47
Extraosseous thoracic foraminal osteoblastoma: diagnostic dilemma and management with 3 year follow-up. ( 25346825 )
2014
48
Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. ( 25224389 )
2014
49
A large multifocal aggressive osteoblastoma of mandible: an immunohistochemistry case study report. ( 25024840 )
2014
50
Cervical osteoid osteoma progression to osteoblastoma. ( 24445325 )
2014

Variations for Osteoblastoma

Expression for Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for Osteoblastoma

Pathways related to Osteoblastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 ADCY1 CTNNB1 TUBB2A

GO Terms for Osteoblastoma

Biological processes related to Osteoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 canonical Wnt signaling pathway GO:0060070 9.37 CTNNB1 ZNRF3
2 negative regulation of angiogenesis GO:0016525 9.32 CTNNB1 SPARC
3 cellular response to growth factor stimulus GO:0071363 9.26 CTNNB1 SPARC
4 negative regulation of Wnt signaling pathway GO:0030178 9.16 CER1 ZNRF3
5 positive regulation of osteoblast differentiation GO:0045669 8.96 CTNNB1 NELL1
6 anterior/posterior axis specification GO:0009948 8.62 CER1 CTNNB1

Sources for Osteoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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