MCID: OST006
MIFTS: 41

Osteoblastoma malady

Bone diseases, Cancer diseases categories

Summaries for Osteoblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the bone. more...

MalaCards: Osteoblastoma is related to osteosarcoma and giant cell tumor. An important gene associated with Osteoblastoma is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways is Cytoskeleton remodeling Keratin filaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and bone marrow.

Aliases & Classifications for Osteoblastoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

osteoblastoma 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:0060098
MESH via Orphanet35 D018215
SNOMED-CT via Orphanet57 55333008
UMLS via Orphanet61 C0029417

Related Diseases for Osteoblastoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.8TP53, SPARC, MT-CO2
2giant cell tumor30.3VIM, MUC1
3fibrous dysplasia29.9SPARC
4hemangiopericytoma29.8VIM, MUC1
5meningioma29.8SPARC, MUC1, VIM
6cervicitis10.5
7periostitis10.5
8sarcoma10.2
9osteomalacia10.2
10bone giant cell tumor10.1
11thyroiditis10.1
12osteofibrous dysplasia10.0SPARC
13pulmonary fibrosis10.0SPARC
14osteoarthritis10.0SPARC
15chondroblastoma10.0ZNF133
16choroid plexus papilloma10.0TP53
17ductal carcinoma in situ10.0TP53
18hepatocellular carcinoma10.0TP53
19medulloblastoma10.0TP53
20glioblastoma multiforme10.0TP53
21malignant fibroxanthoma10.0TP53
22familial adenomatous polyposis10.0TP53
23papilloma10.0TP53
24hemangioblastoma10.0MUC1
25cystadenocarcinoma10.0MUC1
26benign mesothelioma10.0TP53
27eccrine porocarcinoma10.0MUC1
28bladder carcinoma10.0TP53
29hidradenoma10.0MUC1
30syringoma10.0MUC1
31sertoli-leydig cell tumor10.0MUC1
32thymus cancer10.0MUC1
33angiomyolipoma10.0VIM
34adenomatoid tumor10.0VIM
35myoepithelioma10.0VIM
36glomus tumor10.0VIM
37colon cancer10.0SPARC, TP53
38retinoblastoma10.0TP53, SPARC
39kidney cancer10.0TP53
40brain cancer10.0TP53
41granular cell tumor10.0VIM
42parkinson's disease10.0VIM
43oral cancer10.0TP53
44leiomyoma10.0VIM
45adenoma10.0MUC1, TP53
46smooth muscle tumor10.0VIM
47fibrosarcoma10.0VIM, SPARC
48wilms tumor10.0SPARC, VIM
49cholangiocarcinoma10.0TP53, MUC1
50endometrial carcinoma10.0MUC1, TP53

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to osteoblastoma

Clinical Features for Osteoblastoma

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Drugs & Therapeutics for Osteoblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Osteoblastoma

Drug clinical trials:

Search ClinicalTrials for Osteoblastoma

Search NIH Clinical Center for Osteoblastoma

Search CenterWatch for Osteoblastoma

Genetic Tests for Osteoblastoma

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Anatomical Context for Osteoblastoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Osteoblastoma:

32
Bone, Thyroid, Bone marrow, Spinal cord, Pineal

Animal Models for Osteoblastoma or affiliated genes

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Publications for Osteoblastoma

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Sources:
50PubMed
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Articles related to Osteoblastoma:

(show top 50)    (show all 479)
idTitleAuthorsYear
1
A rare case of massive carpal osteoblastoma requiring complex reconstructive surgery. (23490981)
2013
2
Osteoid osteoma and osteoblastoma. (22052644)
2011
3
Fibro-osseous lesion of the pineal region resembling osteoblastoma: a case report. (20667011)
2011
4
Osteoblastoma of the temporal bone. (20190944)
2009
5
A case report of synchronous osteoblastoma and fibromatosis. (18270286)
2008
6
Osteoblastoma of the temporal bone: a case report. (18855299)
2008
7
Osteoblastoma of the ethmoid sinus. (17265159)
2007
8
Classical osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters. (17505702)
2007
9
Osteoblastoma of the larynx: a case report. (16273197)
2005
10
A rare case of periosteal osteoblastoma located in the frontal cranial bone. (15913430)
2005
11
Radiology quiz case 1. Benign osteoblastoma. (16365228)
2005
12
Progression of an osteoid osteoma to an osteoblastoma. Case report. (16235709)
2005
13
Periosteal osteoblastoma of the distal femur. (14714148)
2004
14
Pediatric osteoblastoma of the sternum: a new surgical technique for reconstruction after removal: case report and review of the literature. (15105730)
2004
15
Osteoblastoma of the carpal scaphoid frequency and treatment. (12584985)
2002
16
Recurrent osteoblastoma of the hamate bone. A two-stage reconstruction with a free vascularized iliac crest flap. (10473168)
1999
17
Osteoblastoma of dorsal spine: a case report. (10625912)
1999
18
Intra-articular benign osteoblastoma of the acetabulum: a case report. (10218179)
1999
19
Large cell, epithelioid, telangiectatic osteoblastoma: a unique pseudosarcomatous variant of osteoblastoma. (10534176)
1999
20
Osteoid osteoma and osteoblastoma with clonal chromosome changes. (9703280)
1998
21
Benign osteoblastoma of the temporal bone. (9111670)
1997
22
Osteoblastoma response to radiotherapy and chemotherapy. (9078333)
1997
23
Functional reconstruction in a case of osteoblastoma of the mandibular condyle. (8961012)
1996
24
Osteoid osteoma or osteoblastoma of the cervical spine in relation to the vertebral artery. (7814596)
1994
25
Tumors of the atlas. 3 incidental cases of osteochondroma, benign osteoblastoma, and atypical Ewing's sarcoma. (7924032)
1994
26
Bone scan appearances of a metastasizing aggressive osteoblastoma. A case report. (8344025)
1993
27
Cementoblastoma and osteoblastoma: a comparison of histologic features. (1432731)
1992
28
A rare bone tumor in an unusual location: osteoblastoma of the vertebral body. (1555177)
1992
29
Osteoblastoma: a case report and description of the access used to the retromaxillary area. (1742265)
1991
30
Osteoblastoma. Cause for wry neck. (2636586)
1989
31
Benign osteoblastoma. (2922369)
1989
32
Prostaglandin synthesis by osteoid osteoma and osteoblastoma. (3266336)
1988
33
Osteoblastoma of the jaw bone simulating plasmacytoma. Case report with immunohistochemical study. (3455297)
1987
34
Osteoblastoma of the sternum. (3566508)
1987
35
Osteosarcoma resembling osteoblastoma. (3855268)
1985
36
Osteoid osteoma and benign osteoblastoma of the spine. Clinical presentation and treatment. (6693472)
1984
37
Scoliogenic osteoblastoma of the posterior end of the rib. (6528300)
1984
38
Benign osteoblastoma. Report of a case and review of the literature. (6712523)
1984
39
Benign osteoblastoma of the lumbar spine. (6676308)
1983
40
Central osteoblastoma or cementoblastoma? A case report and 12 year review. (6938238)
1981
41
Angiography of spinal osteoblastoma. (457733)
1979
42
Benign osteoblastoma of cervical spine. (291808)
1979
43
Pseudomalignant osteoblastoma versus arrested osteosarcoma: a case report. (1063057)
1976
44
Benign osteoblastoma. (1064400)
1976
45
Benign osteoblastoma: range of manifestations. (1123354)
1975
46
Osteoid osteoma and osteoblastoma: reclassification of 43 cases using Schajowicz's classification. (1116053)
1975
47
Malignant transformation of benign osteoblastoma. A case report. (1123402)
1975
48
Osteoblastoma of the sacrum with intra-abdominal manifestation. (5032036)
1972
49
Benign osteoblastoma of the rib: report of a case. (5573084)
1971
50
Osteoid osteoma and osteoblastoma. Closely related entities of osteoblastic derivation. (5486182)
1970

Genetic Variations for Osteoblastoma

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Expression for genes affiliated with Osteoblastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for genes affiliated with Osteoblastoma

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12EMD Millipore
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Pathways related to Osteoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TUBA1C, VIM

Compounds for genes affiliated with Osteoblastoma

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Osteoblastoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1eosin4410.0VIM, MUC1
2s 100449.9MUC1, VIM
3reticulin449.9MUC1, VIM
4mucicarmine449.9VIM, MUC1
5b 723449.8MUC1, VIM
6aristolochic acid44 210.8TP53, VIM
7temozolomide44 1110.8VIM, TP53
8crcs449.7MUC1, TP53
9titanium449.6SPARC, VIM
10cytarabine44 49 1111.4TP53, MUC1, VIM
11adriamycin449.4VIM, MUC1, TP53
12n-(4-hydroxyphenyl)retinamide449.4TP53, VIM
13roscovitine449.2TP53, VIM
14sb 20358044 5910.1TP53, SPARC, VIM
15actinomycin d449.1VIM, MUC1, TP53
16paclitaxel44 49 1111.1VIM, SPARC, TP53
17proline448.9TP53, SPARC, VIM
18butyrate448.8TP53, SPARC, MUC1, VIM
19paraffin448.8TP53, SPARC, MUC1, VIM
20progesterone44 59 28 11 2412.8TP53, SPARC, MUC1, VIM
21vegf448.7TP53, SPARC, MUC1, VIM
22estrogen448.6TP53, SPARC, MUC1, VIM
23retinoic acid44 249.5TP53, SPARC, MUC1, VIM

GO Terms for genes affiliated with Osteoblastoma

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16Gene Ontology
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Biological processes related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, MUC1

Molecular functions related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.5TP53, MUC1

Products for genes affiliated with Osteoblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet