MCID: OST006
MIFTS: 35

Osteoblastoma malady

Bone, Cancer categories

Summaries for Osteoblastoma

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the bone. more...

MalaCards: Osteoblastoma is related to fibrous dysplasia and osteomalacia. An important gene associated with Osteoblastoma is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways is Cytoskeleton remodeling Keratin filaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and skeletal muscle.

Aliases & Classifications for Osteoblastoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone


Aliases & Descriptions:

osteoblastoma 8 10 45 49 61


External Ids:

Disease Ontology8 DOID:0060098
MESH via Orphanet36 D018215
SNOMED-CT via Orphanet58 55333008
UMLS via Orphanet62 C0029417

Related Diseases for Osteoblastoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia29.9SPARC
2osteomalacia10.2
3bone giant cell tumor10.1
4osteochondroma10.1
5back pain10.1
6osteofibrous dysplasia10.0SPARC
7pulmonary fibrosis10.0SPARC
8osteoarthritis10.0SPARC
9chondroblastoma10.0ZNF133
10choroid plexus papilloma10.0TP53
11ductal carcinoma in situ10.0TP53
12hepatocellular carcinoma10.0TP53
13medulloblastoma10.0TP53
14glioblastoma multiforme10.0TP53
15malignant fibroxanthoma10.0TP53
16familial adenomatous polyposis10.0TP53
17papilloma10.0TP53
18hemangioblastoma10.0MUC1
19cystadenocarcinoma10.0MUC1
20benign mesothelioma10.0TP53
21eccrine porocarcinoma10.0MUC1
22bladder carcinoma10.0TP53
23hidradenoma10.0MUC1
24syringoma10.0MUC1
25sertoli-leydig cell tumor10.0MUC1
26thymic carcinoma10.0MUC1
27angiomyolipoma10.0VIM
28adenomatoid tumor10.0VIM
29myoepithelioma10.0VIM
30glomus tumor10.0VIM
31colon cancer10.0SPARC, TP53
32retinoblastoma10.0TP53, SPARC
33kidney cancer10.0TP53
34brain cancer10.0TP53
35granular cell tumor10.0VIM
36parkinson's disease10.0VIM
37oral cancer10.0TP53
38leiomyoma10.0VIM
39adenoma10.0MUC1, TP53
40smooth muscle tumor10.0VIM
41fibrosarcoma10.0VIM, SPARC
42wilms tumor10.0SPARC, VIM
43cholangiocarcinoma10.0TP53, MUC1
44endometrial carcinoma10.0MUC1, TP53
45osteosarcoma10.0TP53, SPARC, MT-CO2
46liposarcoma10.0TP53, VIM
47dermatofibrosarcoma protuberans10.0VIM, MUC1
48clear cell ependymoma10.0VIM, MUC1
49rhabdoid tumor10.0MUC1, VIM
50angiosarcoma10.0MUC1, VIM

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to osteoblastoma

Clinical Features for Osteoblastoma

Drugs & Therapeutics for Osteoblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoblastoma

Drug clinical trials:

Search ClinicalTrials for Osteoblastoma

Search NIH Clinical Center for Osteoblastoma

Search CenterWatch for Osteoblastoma

Genetic Tests for Osteoblastoma

Anatomical Context for Osteoblastoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Osteoblastoma:

33
Spinal cord, Bone marrow, Skeletal muscle, Thyroid, Pineal

Animal Models for Osteoblastoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Osteoblastoma

Sources:
51PubMed
See all sources

Articles related to Osteoblastoma:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. (24081688)
2013
2
Frontal sinus osteoma with osteoblastoma-like histology and associated intracranial pneumatocele. (22274656)
2012
3
Osteoblastoma in the nasal cavity: F-18 FDG PET/CT and Tc-99m MDP 3-phase bone scan findings with pathologic correlation. (21285681)
2011
4
Osteoblastoma of the frontal sinuses presenting with headache and blurred vision: case report and review of the literature. (22470734)
2010
5
Case report: a pediatric case of cementoblastoma with histologic and radiographic features of an osteoblastoma and osteosarcoma. (20737258)
2010
6
Posterior-anterior resection of a cervical spine osteoblastoma. (20514498)
2010
7
Osteoblastoma. (20923301)
2010
8
Concurrent osteochondroma and osteoblastoma of the proximal humeral shaft. (19226029)
2009
9
Osteoblastoma in the skeletally immature. (18580372)
2008
10
Osteoblastoma of the orbit. A case report and review of the literature. (24256752)
2008
11
Osteoblastoma: a 30-year study of 99 cases. (18561158)
2008
12
Periosteal osteoblastoma. (17668687)
2007
13
Epithelioid multinodular osteoblastoma: a clinicopathologic analysis of 26 cases. (17667552)
2007
14
Gnathic osteoblastoma: clinicopathologic review of seven cases with long-term follow-up. (16129654)
2006
15
Benign osteoblastoma of the mandibular ramus: review of the literature and report of a case. (11078147)
2000
16
Vertebral osteoblastoma: are radiologic structural changes necessary for diagnosis? (10199297)
1999
17
Spinal osteoblastoma: CT and MR imaging with pathological correlation. (10068073)
1999
18
Acetabular osteoblastoma: description of a case. (10369022)
1998
19
Osteoblastoma of the acetabulum. (9547820)
1998
20
Giant osteoblastoma of temporal bone. Case report. (9698743)
1998
21
Diagnostic criteria for pseudomalignant osteoblastoma. (9279574)
1997
22
Osteoid osteoma and osteoblastoma: MRI appearances and the significance of ring enhancement. (8797998)
1996
23
Spinal osteoblastoma: relationship between paravertebral muscle abnormalities and scoliosis. (8865486)
1996
24
Imaging features of maxillary osteoblastoma and its malignant transformation. (7824976)
1994
25
Case report 874: Left supraorbital osteoblastoma. (7886478)
1994
26
Recurrent osteoblastoma of the mandible: a case report. (8263651)
1994
27
Osteoid osteoma and osteoblastoma of the spine. (1606380)
1992
28
Clinicoradiological diagnosis of benign osteoblastoma of the spine in children. (1931369)
1991
29
Recurrent benign osteoblastoma of the parietal bone. (2631721)
1989
30
Aggressive osteoblastoma. A case previously reported as a recurrent osteoid osteoma. (2722934)
1989
31
Benign osteoblastoma of the parietal bone: case report. (2755569)
1989
32
Radical excision of an osteoblastoma of the cervical spine. A combined anterior and posterior approach. (3958022)
1986
33
Sacral osteoid osteoma and osteoblastoma: a report of 13 cases. (3753174)
1986
34
Benign osteoblastoma of the atlas: a case report. (4056630)
1985
35
Case report 255. Osteoblastoma of the lesser trochanter of the left femur. (6710183)
1984
36
Benign osteoblastoma of the temporal bone. (6859240)
1983
37
Aggressive osteoblastoma. (469645)
1979
38
Recurrent osteoblastoma: a review. (657629)
1978
39
Benign osteoblastoma of the thoracic spine. Case report with fifteen-year follow-up. (701322)
1978
40
Primary intracerebral osteoblastoma. Case report. (894351)
1977
41
Osteoid osteoma and osteoblastoma. Similar histologic lesions with different natural histories. (598169)
1977
42
Benign osteoblastoma of the calcaneous. (912979)
1977
43
A metacarpal giant cell tumor, a sternal osteoblastoma and a pubic osteogenic sarcoma in the same patient. (1064178)
1976
44
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
45
Benign osteoblastoma of the skull. Case report. (4420628)
1974
46
Benign osteoblastoma of the mandible: report of case. (4501963)
1972
47
Benign osteoblastoma of the spine. Case report. (5257291)
1969
48
Benign osteoblastoma of the vertebra. Report of a case with five-year follow-up after irradiation. (5243821)
1968
49
Solitary benign osteoblastic lesions of bone. Osteoid osteoma and benign osteoblastoma. (5243469)
1968
50
Benign osteoblastoma. A case report. (5722842)
1968

Genetic Variations for Osteoblastoma

Expression for genes affiliated with Osteoblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoblastoma

Search GEO for disease gene expression data for Osteoblastoma.

Pathways for genes affiliated with Osteoblastoma

Sources:
12EMD Millipore
See all sources

Pathways related to Osteoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TUBA1C, VIM

Compounds for genes affiliated with Osteoblastoma

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Osteoblastoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1eosin4510.0VIM, MUC1
2s 100459.9MUC1, VIM
3reticulin459.9MUC1, VIM
4mucicarmine459.9VIM, MUC1
5b 723459.8MUC1, VIM
6aristolochic acid45 210.8TP53, VIM
7temozolomide45 1110.8VIM, TP53
8crcs459.7MUC1, TP53
9titanium459.6SPARC, VIM
10cytarabine45 50 1111.4TP53, MUC1, VIM
11adriamycin459.4VIM, MUC1, TP53
12n-(4-hydroxyphenyl)retinamide459.4TP53, VIM
13roscovitine459.2TP53, VIM
14sb 20358045 6010.1TP53, SPARC, VIM
15actinomycin d459.1VIM, MUC1, TP53
16paclitaxel45 50 1111.1VIM, SPARC, TP53
17proline458.9TP53, SPARC, VIM
18butyrate458.8TP53, SPARC, MUC1, VIM
19paraffin458.8TP53, SPARC, MUC1, VIM
20progesterone45 60 29 11 2412.8TP53, SPARC, MUC1, VIM
21vegf458.7TP53, SPARC, MUC1, VIM
22estrogen458.6TP53, SPARC, MUC1, VIM
23retinoic acid45 249.5TP53, SPARC, MUC1, VIM

GO Terms for genes affiliated with Osteoblastoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, MUC1

Molecular functions related to Osteoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.5TP53, MUC1

Products for genes affiliated with Osteoblastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet