MCID: OST006
MIFTS: 38

Osteoblastoma malady

Bone diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Osteoblastoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Osteoblastoma, Aliases & Descriptions:

Name: Osteoblastoma 9 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:0060098
Orphanet47 58040
UMLS via Orphanet61 C0029417
MESH via Orphanet34 D018215

Summaries for Osteoblastoma

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Wikipedia:63 Osteoblastoma is an uncommon osteoid tissue-forming primary neoplasm of the bone. more...

MalaCards based summary: Osteoblastoma is related to fibrous dysplasia and giant cell tumor. An important gene associated with Osteoblastoma is MT-CO2 (mitochondrially encoded cytochrome c oxidase II), and among its related pathways are EGFR Signaling Pathway and Cytoskeleton remodeling Keratin filaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and bone marrow, and related mouse phenotype vision/eye.

Related Diseases for Osteoblastoma

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Diseases related to Osteoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia30.7SPARC
2giant cell tumor30.5VIM, MUC1
3sarcoma30.1TP53, VIM, MUC1
4hemangiopericytoma30.0VIM, MUC1
5cervicitis10.6
6periostitis10.6
7scoliosis10.5
8aneurysmal bone cysts10.5
9aneurysm10.5
10choroid plexus papilloma10.4TP53
11renal cell carcinoma10.4TP53
12eccrine porocarcinoma10.4MUC1
13hidradenoma10.4MUC1
14syringoma10.4MUC1
15cystadenocarcinoma10.4MUC1
16adenomatoid tumor10.3VIM
17glomus tumor10.3VIM
18osteomalacia10.2
19back pain10.2
20cataract10.2SPARC
21endometrial cancer10.2MUC1, TP53
22sinusitis10.1
23ameloblastoma10.1
24idiopathic scoliosis10.1
25thyroiditis10.1
26osteochondroma10.1
27cholangiocarcinoma10.1MUC1, TP53
28clear cell ependymoma10.1MUC1, VIM
29spindle cell carcinoma10.1MUC1, VIM
30spindle cell sarcoma10.1VIM, MUC1
31epithelioid sarcoma10.1VIM, MUC1
32sertoli cell tumor10.1VIM, MUC1
33dermatofibrosarcoma protuberans10.1VIM, MUC1
34secretory meningioma10.1VIM, MUC1
35rhabdoid tumor10.1VIM, MUC1
36perineurioma10.1VIM, MUC1
37sex cord-gonadal stromal tumor10.1VIM, MUC1
38chordoma10.0MUC1, VIM
39angiosarcoma10.0MUC1, VIM
40malignant peripheral nerve sheath tumor10.0VIM, MUC1
41abrikosov's tumor10.0VIM, MUC1
42neurofibroma10.0VIM, MUC1
43osteosarcoma, somatic10.0SPARC, TP53, MT-CO2
44pleomorphic adenoma10.0VIM, MUC1
45carcinoid syndrome10.0SPARC, MUC1
46salivary gland adenoid cystic carcinoma10.0VIM, MUC1
47ependymoma10.0MUC1, VIM
48stomach cancer10.0SPARC, TP53, MUC1
49oxyphilic adenoma10.0MUC1, VIM
50liposarcoma10.0TP53, VIM

Graphical network of the top 20 diseases related to Osteoblastoma:



Diseases related to osteoblastoma

Symptoms for Osteoblastoma

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Drugs & Therapeutics for Osteoblastoma

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Drug clinical trials:

Search ClinicalTrials for Osteoblastoma

Search NIH Clinical Center for Osteoblastoma

Genetic Tests for Osteoblastoma

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Anatomical Context for Osteoblastoma

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MalaCards organs/tissues related to Osteoblastoma:

31
Bone, Thyroid, Bone marrow, Spinal cord, Pineal

Animal Models for Osteoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Osteoblastoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5MUC1, VIM, TP53, SPARC

Publications for Osteoblastoma

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Articles related to Osteoblastoma:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Cervical osteoid osteoma progression to osteoblastoma. (24445325)
2014
2
I^-catenin is a valuable marker for differential diagnosis of osteoblastoma and osteosarcoma. (24746516)
2014
3
Aggressive multilocular osteoblastoma in the mandible: a rare and difficult case to diagnose. (25517784)
2014
4
Osteoblastoma Is a Metabolically Active Benign Bone Tumor on 18F-FDG PET Imaging. (24144518)
2013
5
Osteoblastoma of the inferior turbinate. (21493259)
2011
6
Osteoblastoma of the sternum--case report and review of the literature. (20345366)
2010
7
Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature. (21412027)
2010
8
Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. (19963118)
2009
9
Concurrent osteochondroma and osteoblastoma of the proximal humeral shaft. (19226029)
2009
10
Osteoblastoma of the temporal bone. (20190944)
2009
11
Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases. (19589324)
2009
12
Pathology quiz case 2. Osteoblastoma. (19451478)
2009
13
Osteoblastoma in the skeletally immature. (18580372)
2008
14
Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. (17641905)
2008
15
Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. (19050575)
2008
16
Osteoblastoma crossing the sacro-iliac joint. (16552607)
2007
17
Progression of a lumbar spinal osteoblastoma. (16041187)
2005
18
Osteoblastoma of the larynx: a case report. (16273197)
2005
19
A rare case of periosteal osteoblastoma located in the frontal cranial bone. (15913430)
2005
20
Radiation therapy for sacral osteoblastoma. (12708718)
2003
21
"Occult" roentgenographic osteoblastoma of the cervical spine. (14508414)
2003
22
Osteoblastoma of transverse process of 8th dorsal vertebra. (12696737)
2002
23
Osteoblastoma-like osteosarcoma. (11201036)
2000
24
Recurrent osteoblastoma of the hamate bone. A two-stage reconstruction with a free vascularized iliac crest flap. (10473168)
1999
25
Recurrent osteoblastoma of the hamate bone. (10672826)
1999
26
Benign osteoblastoma of the odontoid process of the axis: a case report. (9508114)
1998
27
Osteoid osteoma and osteoblastoma: MRI appearances and the significance of ring enhancement. (8797998)
1996
28
Osteoblastoma in the anterior maxilla mimicking periapical pathosis of odontogenic origin. (8618097)
1996
29
Osteoid osteoma or osteoblastoma of the cervical spine in relation to the vertebral artery. (7814596)
1994
30
Osteoblastoma: clinicopathologic study of 306 cases. (8119712)
1994
31
Massive benign osteoblastoma of the clivus and atlas. (7811416)
1994
32
Acquired vitamin D-resistant rickets caused by aggressive osteoblastoma in the pelvis: a case report with ten years' follow-up and review of the literature. (7814597)
1994
33
Imaging features of maxillary osteoblastoma and its malignant transformation. (7824976)
1994
34
Bone scan appearances of a metastasizing aggressive osteoblastoma. A case report. (8344025)
1993
35
Osteoblastoma-like osteosarcoma. The Rizzoli Institute experience. (8302813)
1993
36
A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case. (8478388)
1993
37
Recurrent benign osteoblastoma of the parietal bone. (2631721)
1989
38
Spinal osteoblastoma in an 11-year-old boy. (3393954)
1988
39
Rib osteoblastoma: a clinical manifestation. (3406842)
1988
40
Scoliosis secondary to osteoblastoma of the rib. (3624472)
1987
41
Benign osteoblastoma of the clivus removed by a transoral approach: case report. (3808275)
1987
42
Radical excision of an osteoblastoma of the cervical spine. A combined anterior and posterior approach. (3958022)
1986
43
Can an osteoblastoma become malignant? (3936268)
1985
44
Benign osteoblastoma of the maxillary sinus. (6665425)
1983
45
An unusual case of osteoblastoma of the femur. (6885392)
1983
46
Collagen and noncollagen protein synthesis in chick limb bud cells infected with a virus that causes osteoblastoma. (7289876)
1981
47
Benign osteoblastoma of the jaws: report of three cases. (6931893)
1980
48
The spectrum of osteoblastoma. (175701)
1976
49
Benign osteoblastoma. (1054453)
1975
50
Osteoid osteoma--osteoblastoma. (4819213)
1974

Variations for Osteoblastoma

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Expression for genes affiliated with Osteoblastoma

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Search GEO for disease gene expression data for Osteoblastoma.

Pathways for genes affiliated with Osteoblastoma

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Pathways related to Osteoblastoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MUC1, TP53
29.5VIM, TUBA1C
39.3TP53, SPARC

Compounds for genes affiliated with Osteoblastoma

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Compounds related to Osteoblastoma according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1eosin4310.0MUC1, VIM
2s 1004310.0MUC1, VIM
3reticulin4310.0MUC1, VIM
4mucicarmine4310.0MUC1, VIM
5b 723439.9MUC1, VIM
6aristolochic acid43 210.9TP53, VIM
7temozolomide43 1210.9VIM, TP53
8crcs439.9TP53, MUC1
9hematoxylin439.9VIM, MUC1
10n-(4-hydroxyphenyl)retinamide439.8VIM, TP53
11roscovitine439.8TP53, VIM
12titanium439.7SPARC, VIM
13vinblastine43 49 1211.7VIM, TP53
14progestin439.7VIM, MUC1
15colchicine43 59 2 28 1213.6VIM, TUBA1C
16hydroxyapatite439.6VIM, SPARC
17procollagen439.6SPARC, VIM
18chondroitin sulfate43 2410.5VIM, SPARC
19cytarabine43 49 1211.5TP53, VIM, MUC1
20adriamycin439.5MUC1, VIM, TP53
21gemcitabine43 49 1211.4TP53, MUC1
22tamoxifen43 49 28 1212.4MUC1, VIM, TP53
23actinomycin d439.4MUC1, VIM, TP53
24lactate439.3MT-CO2, VIM, SPARC
25sb 20358043 5910.2VIM, TP53, SPARC
26paclitaxel43 49 1211.2VIM, TP53, SPARC
27nocodazole43 1210.2TP53, VIM
28proline439.2SPARC, TP53, VIM
29thymidine43 2410.2MUC1, TP53, SPARC
30testosterone43 59 24 1212.0MUC1, VIM, SPARC
31butyrate438.9MUC1, VIM, TP53, SPARC
32paraffin438.9SPARC, TP53, VIM, MUC1
33oligonucleotide438.9VIM, TP53, SPARC
34progesterone43 28 59 24 1212.9SPARC, TP53, VIM, MUC1
35vegf438.9SPARC, TP53, VIM, MUC1
36estrogen438.8SPARC, TP53, VIM, MUC1
37retinoic acid43 249.8SPARC, TP53, VIM, MUC1

GO Terms for genes affiliated with Osteoblastoma

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Cellular components related to Osteoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.5MUC1, TP53

Biological processes related to Osteoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.5MUC1, TP53
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.2MUC1, TP53

Molecular functions related to Osteoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:000520010.0TUBA1C
2p53 bindingGO:00020399.2MUC1, TP53

Products for genes affiliated with Osteoblastoma

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  • Antibodies
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  • Kits and Assays

Sources for Osteoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet