Osteochondritis Dissecans malady
Categories: Genetic diseases, Rare diseases, Bone diseases
Aliases & Descriptions for Osteochondritis Dissecans:
Orphanet epidemiological data:51
Age of onset: All ages; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases
ICD10: 28 27
NIH Rare Diseases:45 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015
MalaCards based summary: Osteochondritis Dissecans, also known as osteochondritis, is related to osteochondrosis and familial osteochondritis dissecans. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways are Gastric cancer network 2 and Protein digestion and absorption. The drugs citalopram and citalopram hydrobromide have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, bone and brain, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.
Disease Ontology:10 An ischemic bone disease that results in necrosis located in epiphysis.
Wikipedia:68 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...
Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:(show all 20)
Search NIH Clinical Center for Osteochondritis Dissecans
Inferred drug relations via UMLS65/NDF-RT43:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
MalaCards organs/tissues related to Osteochondritis Dissecans:33
Bone, Brain, Breast, Liver, Bone marrow, Endothelial, Heart
FMA organs/tissues related to Osteochondritis Dissecans:16
MGI Mouse Phenotypes related to Osteochondritis Dissecans:38
Articles related to Osteochondritis Dissecans:(show top 50) (show all 594)
Search GEO for disease gene expression data for Osteochondritis Dissecans.
Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:(show all 14)
Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:
Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet