MCID: OST009
MIFTS: 50

Osteochondritis Dissecans malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
11Disease Ontology, 13DISEASES, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 34LifeMap Discovery®, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 34 11 47 53 26 38 13 67
Osteochondritis 38 67
König Disease 47 53
 
Ocd 11 13
Obsessive-Compulsive Disorder 67
Kônig Disease 47

Characteristics:

Orphanet epidemiological data:

53
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:84
ICD1029 M93.2, M93.9
ICD9CM31 732.7
Orphanet53 ORPHA2764
ICD10 via Orphanet30 M93.2
MESH via Orphanet39 D010008
UMLS via Orphanet68 C0029421

Summaries for Osteochondritis Dissecans

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Wikipedia:70 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

MalaCards based summary: Osteochondritis Dissecans, also known as osteochondritis, is related to osteochondrosis and osteonecrosis. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways are Gastric cancer network 2 and Articular Cartilage Extracellular Matrix Pathway. The drugs venlafaxine hydrochloride and fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, bone and bone marrow, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:11 An ischemic bone disease that results in necrosis located in epiphysis.

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1osteochondrosis29.4ACAN, COL9A1, COMP, MATN3, MMP13
2osteonecrosis25.2ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP
3osteochondritis dissecans, short stature, and early-onset osteoarthritis12.6
4familial osteochondritis dissecans12.6
5obsessive-compulsive disorder11.6
6trichotillomania11.1
7gilles de la tourette syndrome11.1
8idiopathic avascular necrosis11.1
9cerebral hemorrhage10.3ACAN, COMP
10smed strudwick type10.3ACAN, COMP
11acromesomelic dysplasia10.2ACAN, COMP
12atrioventricular septal defect10.2COL9A2, COMP
13sweat gland cancer10.2ACAN, COMP
14legg-calve-perthes disease10.2
15periostitis10.2
16isolated congenital nasal pyriform aperture stenosis10.2COL9A1, COL9A2, COL9A3
17isotretinoin syndrome10.1COL9A1, COL9A2, COL9A3
18extraskeletal chondroma10.1ACAN, COMP
19osteopathia striata with pigmentary dermopathy including white forelock10.1COMP, MATN3
20thiemann disease10.1
21kohler's disease10.1
22osgood-schlatter's disease10.1
23kienbock's disease10.1
24osteoarthritis10.1
25stickler syndrome10.1
26multiple epiphyseal dysplasia10.1
27bone resorption disease10.0ACAN, BMP7
28dengue hemorrhagic fever10.0ACAN, MMP13
29malignant giant cell tumor9.9ACAN, COMP, MMP13
30xanthomatosis9.9ACAN, COMP, MMP13
31wilson disease9.9
32spondyloepiphyseal dysplasia tarda9.9
33rickets9.9
34myopathy9.9
35dwarfism9.9
36intervertebral disc disease9.9COL9A2, COL9A3
37spondylolisthesis9.9ACAN, COL9A1, COL9A2, COL9A3
38ischemic bone disease9.9COL9A2, COMP, MATN3
39spondyloepimetaphyseal dysplasia9.9ACAN, MATN3, MMP13
40bone structure disease9.4ACAN, BMP7, COL9A2, COL9A3, MMP13
41myasthenia, limb-girdle, with tubular aggregates9.4COL9A1, COL9A2, COL9A3, COMP, MATN3
42chromosomal disease9.4ACAN, BMP7, COL9A2, COL9A3, MMP13
43pars planitis9.4COL9A1, COL9A2, COL9A3, COMP, MATN3
44familial pulmonary arterial hypertension leucopenia and atrial septal defect9.2ACAN, FBLN1, FBLN2, TNR
45immunodeficiency 309.1ACAN, COL9A1, COL9A2, COL9A3, COMP, MATN3

Comorbidity relations with Osteochondritis Dissecans via Phenotypic Disease Network (PDN):


Anxiety DisorderGeneralized Anxiety Disorder
HypothyroidismMajor Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment
Dependent Personality DisorderDysthymic Disorder
Obsessive-Compulsive Personality DisorderSchizophreniform Disorder

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Drugs & Therapeutics for Osteochondritis Dissecans

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Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Fibrin Tissue AdhesivePhase 3145
2MitogensPhase 31526
3AstragalusNutraceuticalPhase 352

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Evaluation of the Agili-C Biphasic Implant in the Knee JointActive, not recruitingNCT01471236Phase 4
2Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)WithdrawnNCT01283737Phase 4
3Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional MicrofractureUnknown statusNCT01498029Phase 3
4A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects.CompletedNCT02993510Phase 3
5"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral LesionsRecruitingNCT02005861Phase 3
6ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the KneeActive, not recruitingNCT01458782Phase 2, Phase 3
7Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage DefectsUnknown statusNCT01694823Phase 1, Phase 2
8Osteochondritis Dissecans of the KneeUnknown statusNCT01455987
9Repair of Articular Osteochondral DefectUnknown statusNCT01409447
10Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the AnkleUnknown statusNCT01405664
11Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadUnknown statusNCT00813267Early Phase 1
12Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the KneeUnknown statusNCT01159899Early Phase 1
13Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionUnknown statusNCT02289976
14Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
15Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
16Osteochondritis Dissecans of Knee Prospective CohortRecruitingNCT02771496
17Conjoint Analysis of Patient Preferences in Joint InterventionsRecruitingNCT02664337
18DeNovo NT Longitudinal Data Collection (LDC) Knee StudyActive, not recruitingNCT01329445
19DeNovo NT Ankle LDC StudyActive, not recruitingNCT01347892
20Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage RegenerationTerminatedNCT00881023
21Chondrofix Osteochondral Allograft Prospective StudyTerminatedNCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS67/NDF-RT45:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455


Cochrane evidence based reviews: osteochondritis

Genetic Tests for Osteochondritis Dissecans

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Genetic tests related to Osteochondritis Dissecans:

id Genetic test Affiliating Genes
1 Osteochondritis Dissecans26

Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

35
Bone, Bone marrow

FMA organs/tissues related to Osteochondritis Dissecans:

17
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3BMP7, COL9A1, COL9A2, FBLN1
2MP:00053717.8BMP7, COL9A1, COL9A2, COMP, FBLN1, MATN3
3MP:00053907.1BMP7, COL9A1, COL9A2, COMP, FBLN1, MATN3

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Osteochondritis dissecans located on the medial tibial plateau: a case report. (28049517)
2017
2
Arthroscopic Bioabsorbable Screw Fixation of Unstable Osteochondritis Dissecans in Adolescents: Clinical Results, Magnetic Resonance Imaging, and Second-Look Arthroscopic Findings. (26929800)
2016
3
Management of Osteochondritis Dissecans of the Femoral Condyle. (27479835)
2016
4
A suspected genetic form of bilateral osteochondritis dissecans of the knee in a Dutch family. (26122666)
2015
5
Treatment algorithm for osteochondritis dissecans of the knee. (25435043)
2015
6
Candidate Loci are Revealed by an Initial Genome-wide Association Study of Juvenile Osteochondritis Dissecans. (26422391)
2015
7
Osteochondritis dissecans of the knee. (25606539)
2014
8
Bilateral Wrisberg discoid menisci mimicking bucket handle tears associated with osteochondritis dissecans: case report. (25171571)
2014
9
State of the art: Elbow arthroscopy: review of the literature and application for osteochondritis dissecans of the capitellum. (25264040)
2014
10
Osteochondritis dissecans development after bone contusion of the knee in the skeletally immature: a case series. (22481267)
2013
11
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
12
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
13
Juvenile osteochondritis dissecans of the knee: predictors of lesion stability. (22173379)
2012
14
Osteochondritis dissecans of the humeral head. (23023034)
2012
15
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
16
Elbow arthroscopy: capitellar osteochondritis dissecans and radiocapitellar plica. (21553772)
2011
17
Osteochondral autograft transplantation for osteochondritis dissecans of the scaphoid: case report. (21527139)
2011
18
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
19
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
20
Association between clinical signs and histopathologic changes in the synovium of the tarsocrural joint of horses with osteochondritis dissecans of the tibia. (20043780)
2010
21
Case report: Osteochondritis dissecans in twins: treatment with fresh osteochondral grafts. (19662464)
2010
22
Arthroscopic technique for fragment fixation using absorbable pins for osteochondritis dissecans of the humeral capitellum: a report of 4 cases. (19859694)
2010
23
Patella osteochondritis dissecans end stage: The osteochondral mosaicplasty option. (20638920)
2010
24
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
25
Osteochondritis dissecans of the capitellum in fraternal twins: case report. (18929205)
2008
26
Should in the treatment of osteochondritis dissecans biodegradable or metallic fixation devices be used? A comparative study in goat knees. (17477389)
2008
27
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
28
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
29
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
30
Internal fixation of unstable Cahill Type-2C osteochondritis dissecans lesions of the knee in adolescent patients. (17598495)
2007
31
Juvenile osteochondritis dissecans of the talus. (17878792)
2007
32
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
33
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
34
Arthroscopic reattachment of osteochondritis dissecans lesions using resorbable polydioxanone pins. (15253076)
2004
35
Increased external tibial torsion and osteochondritis dissecans of the knee. (15187853)
2004
36
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
37
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
38
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
39
Osteochondritis dissecans in a patient with hyperimmunoglobulin E syndrome. (12458817)
2002
40
Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. (11536094)
2001
41
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
42
Pitfalls associated with fixation of osteochondritis dissecans fragments using bioabsorbable screws. (11337726)
2001
43
Osteochondritis dissecans of the knee. (20086997)
1996
44
Activation of the complement system and adverse effects of biodegradable pins of polylactic acid (Biofix) in osteochondritis dissecans. (7976300)
1994
45
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
46
Osteochondritis dissecans of the elbow. A long-term follow-up study. (1395286)
1992
47
Arthroscopic management of transchondral talar-dome fractures (osteochondritis dissecans) and anterior impingement lesions of the ankle joint. (1868568)
1991
48
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
49
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
50
Osteochondritis dissecans and other lesions of the femoral condyles. (2722949)
1989

Variations for Osteochondritis Dissecans

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Clinvar genetic disease variations for Osteochondritis Dissecans:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ACANNM_013227.3(ACAN): c.7249G> A (p.Val2417Met)SNVPathogenicrs267606625GRCh37Chr 15, 89416172: 89416172

Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.8COL9A1, COL9A3
29.8ACAN, COMP
39.5COL9A1, COL9A2, COL9A3
49.5COL9A1, COL9A2, COL9A3
59.2ACAN, BMP7, MMP13
6
Show member pathways
9.1COL9A1, COL9A2, COL9A3, MMP13
7
Show member pathways
8.8ACAN, COL9A1, COL9A2, COL9A3, MMP13
88.7COL9A1, COL9A2, COL9A3, COMP, TNR
9
Show member pathways
8.7COL9A1, COL9A2, COL9A3, COMP, TNR
10
Show member pathways
8.7COL9A1, COL9A2, COL9A3, COMP, TNR
11
Show member pathways
8.7ACAN, BMP7, COL9A1, COL9A2, COL9A3
12
Show member pathways
8.5BMP7, FBLN1, FBLN2
138.4ACAN, FBLN1, FBLN2, TNR
147.9ACAN, COL9A1, COL9A2, COL9A3, COMP, MATN3
15
Show member pathways
5.5ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen type IX trimerGO:000559410.1COL9A1, COL9A2, COL9A3
2endoplasmic reticulum lumenGO:00057889.7COL9A1, COL9A2, COL9A3
3extracellular matrixGO:00310127.8ACAN, BMP7, COMP, FBLN1, FBLN2
4proteinaceous extracellular matrixGO:00055785.9ACAN, COL9A1, COL9A2, COL9A3, COMP, FBLN1
5extracellular regionGO:00055765.5ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth plate cartilage developmentGO:000341710.0COMP, MMP13
2animal organ morphogenesisGO:00098879.3BMP7, COL9A1, COMP
3skeletal system developmentGO:00015018.1ACAN, BMP7, COL9A2, COMP, MATN3
4extracellular matrix organizationGO:00301987.1ACAN, COL9A1, COL9A2, COL9A3, COMP, FBLN1

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:00055189.9COMP, MMP13
2extracellular matrix structural constituent conferring tensile strengthGO:00300209.9COL9A1, COL9A2, COL9A3
3fibronectin bindingGO:00019689.5FBLN1, MMP13
4extracellular matrix structural constituentGO:00052018.2ACAN, COMP, FBLN1, FBLN2, MATN3
5calcium ion bindingGO:00055097.6COMP, FBLN1, FBLN2, MATN3, MMP13

Sources for Osteochondritis Dissecans

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet