OD
MCID: OST009
MIFTS: 62

Osteochondritis Dissecans (OD) malady

Bone diseases category

Summaries for Osteochondritis Dissecans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. the loose piece may stay in place or fall into the joint space, making the joint unstable. this causes pain and feelings that the joint "sticks" or is "giving way." osteochondritis dissecans usually affects the knees and elbows. last updated: 6/4/2009

MalaCards: Osteochondritis Dissecans, also known as aseptic necrosis, is related to multiple sclerosis and stickler syndrome. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Degradation of collagen and Protein digestion and absorption. The drugs citalopram and clomipramine and the compounds polyglycolic acid and 1-Methyloxy-4-Sulfone-Benzene have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:3 Deaths from drug overdose have been rising steadily over the past two decades and have become the leading cause of injury death in the United States.1  Every day in the United States, 105 people die as a result of drug overdose, and another 6,748 are treated in emergency departments (ED) for the misuse or abuse of drugs.2 Nearly 9 out of 10 poisoning deaths are caused by drugs.3

Wikipedia:63 Osteochondritis dissecans /ˌɒsti.oʊkɒnˈdraɪtɪs ˈdɪsɨkænz/, often abbreviated to OCD or OD, is... more...

Description from OMIM:46 165800

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondritis dissecans 8 42 10 30 60
aseptic necrosis 42 60
obsessive-compulsive disorder 60
ocd 8
od 42


External Ids:

Disease Ontology8 DOID:84
NCIt39 C34877
OMIM46 165800
MeSH34 D010007
ICD1025 M93.2

Related Diseases for Osteochondritis Dissecans

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.6TNR
2stickler syndrome30.5COL9A1, COL9A2
3multiple epiphyseal dysplasia30.5COL9A1, COL9A2, COL9A3, MATN3, ACAN
4osteosarcoma30.5BMP7, CD36, MMP13, NOTCH1
5osteoarthritis30.5COL9A1, COL9A2, COL9A3, BMP7, MATN3, CD36
6astrocytoma30.2MMP3, GAPDH
7arthritis30.0ACAN, MMP3
8body dysmorphic disorder10.9
9familial osteochondritis dissecans10.8
10schizophrenia10.8
11generalized anxiety disorder10.7
12major depressive disorder10.7
13hypochondriasis10.7
14obsessive-compulsive disorder10.7
15social phobia10.7
16bipolar disorder10.7
17anorexia nervosa10.6
18eating disorder10.6
19osteochondrosis10.6
20schizotypal personality disorder10.6
21dissociative disorder10.6
22mood disorder10.6
23sexual disorder10.6
24attention deficit hyperactivity disorder10.5
25alexithymia10.5
26cerebritis10.5
27neuroacanthocytosis10.5
28osteochondrodysplasia10.5
29osteonecrosis10.4
30legg-calve-perthes disease10.4
31periostitis10.4
32asperger syndrome10.4
33schizoaffective disorder10.4
34scurvy10.3
35autistic disorder10.3
36bulimia nervosa10.3
37somatization disorder10.3
38adjustment disorder10.3
39seasonal affective disorder10.3
40pain disorder10.3
41alcohol dependence10.3
42autism spectrum disorder10.3
43impulse control disorder10.3
44psychotic disorder10.3
45charge syndrome10.3
46myoclonus-dystonia10.3
47carpal tunnel syndrome10.2
48rickets10.2
49wilson disease10.2
50osgood-schlatter's disease10.2

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Clinical Features for Osteochondritis Dissecans

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Sources:
46OMIM
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Clinical features from OMIM:

165800

Drugs & Therapeutics for Osteochondritis Dissecans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteochondritis Dissecans

Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Search CenterWatch for Osteochondritis Dissecans

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteochondritis Dissecans:

32
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

14
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5COL9A1, BMP7, FBLN1, MATN3, MMP13, ACAN
2MP:00053778.3COL9A1, BMP7, FBLN1, NOTCH1, ACAN
3MP:00053787.3GAPDH, FBLN1, MATN3, CD36, MMP13, NOTCH1
4MP:00053907.2ACAN, COL9A1, BMP7, FBLN1, MATN3, CD36
5MP:00053857.2BMP7, GAPDH, FBLN2, FBLN1, CD36, MMP13
6MP:00053877.1COL9A1, BMP7, FBLN1, MATN3, CD36, MMP3

Publications for Osteochondritis Dissecans

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Sources:
50PubMed
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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
2
Matching osteochondritis dissecans lesions in identical twin brothers. (24025016)
2013
3
Conservative treatment for juvenile osteochondritis dissecans of the talus. (22933674)
2012
4
Juvenile osteochondritis dissecans: is it a growth disturbance of the secondary physis of the epiphysis? (23096188)
2012
5
In vitro phenotypic modulation of chondrocytes from knees of patients with osteochondritis dissecans: implications for chondrocyte implantation procedures. (22219249)
2012
6
Surgical management of juvenile osteochondritis dissecans of the knee. (22327618)
2012
7
Retrograde drilling of talar osteochondritis dissecans lesions: a feasibility and accuracy analysis of a novel electromagnetic navigation method versus a standard fluoroscopic method. (22683373)
2012
8
Ossification variants of the femoral condyles are not associated with osteochondritis dissecans. (22297186)
2012
9
The clinical utility and diagnostic performance of MRI for identification and classification of knee osteochondritis dissecans. (22637210)
2012
10
MRI-guided percutaneous retrograde drilling of osteochondritis dissecans of the knee. (21327672)
2011
11
Meniscoplasty for stable osteochondritis dissecans of the lateral femoral condyle combined with a discoid lateral meniscus: a case report. (21896174)
2011
12
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
13
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
14
Case report: Osteochondritis dissecans in twins: treatment with fresh osteochondral grafts. (19662464)
2010
15
Transplantation of tissue-engineered cartilage for the treatment of osteochondritis dissecans in the elbow: outcomes over a four-year follow-up in two patients. (20850993)
2010
16
Femoral condyle lesion similar to osteochondritis dissecans. (20848050)
2010
17
Osteochondritis dissecans of the femoral head. (21157754)
2010
18
Osteochondritis dissecans of the elbow. (20541332)
2010
19
You're the flight surgeon. Osteochondritis dissecans. (20540457)
2010
20
Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes. (19626325)
2010
21
Lameness and effusion of the tarsocrural joints after arthroscopy of osteochondritis dissecans in horses. (20008343)
2009
22
Histologic findings and possible causes of osteochondritis dissecans of the knee. (19737988)
2009
23
Pseudointercondylar notch sign: manifestation of osteochondritis dissecans of the trochlea. (19011851)
2009
24
Oblique osteochondral plugs transplantation technique for osteochondritis dissecans of the elbow joint. (18836700)
2009
25
Osteochondritis dissecans of the knee: sonographically guided percutaneous drilling. (18204016)
2008
26
Magnetic resonance imaging in the evaluation of osteochondritis dissecans of the patella. (17694305)
2007
27
Comparison of the stability of various internal fixators used in the treatment of osteochondritis dissecans--a mechanical model. (17205560)
2007
28
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
29
Management of osteochondritis dissecans of the knee: current concepts review. (16794036)
2006
30
Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia. (16817736)
2006
31
Osteochondritis dissecans of the subtalar articular facet: an unusual diagnosis. (15841367)
2005
32
Increased external tibial torsion and osteochondritis dissecans of the knee. (15187853)
2004
33
Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models. (15205626)
2004
34
Autologous chondrocyte transplantation for osteochondritis dissecans of the talus. (11937880)
2002
35
Fresh osteochondral grafting in the treatment of osteochondritis dissecans of the talus. (12741584)
2002
36
Microscopic localization of active gelatinases in equine osteochondritis dissecans (OCD) cartilage. (12479388)
2002
37
Fate of the osteochondral fragments in osteochondritis dissecans after Legg-Calve-Perthes' disease. (12358366)
2002
38
Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. (11536094)
2001
39
Osteochondritis dissecans of the elbow. (11227698)
2001
40
Etiological aspects in osteochondritis dissecans patellae. (10639653)
1999
41
The prognostic value of quantitative bone scan in knee osteochondritis dissecans. A preliminary experience. (9474395)
1998
42
Osteochondritis dissecans of the talus during childhood and adolescence. (9600558)
1998
43
Osteochondritis dissecans of the knee fixed with biodegradable self-reinforced polyglycolide and polylactide rods in 24 patients. (9498141)
1997
44
Osteochondritis dissecans of the head of the talus. (9208296)
1997
45
Experimental osteochondritis dissecans--the role of cartilage canals in chondral fractures of young rabbits. (8753020)
1996
46
Osteochondritis Dissecans of the Knee: Treatment of Juvenile and Adult Forms. (10795030)
1995
47
MRI of healing osteochondritis dissecans fragment with absorbable pins. (8089339)
1994
48
Osteochondritis dissecans: a historical review and its treatment with cannulated screws. (8305105)
1993
49
Osteochondritis dissecans of the humeral head. (1550644)
1992
50
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990

Genetic Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MMP3, MMP13
29.6COL9A3, COL9A2, COL9A1
3
Hide members
9.6COL9A3, COL9A2, COL9A1
4
Cell adhesion ECM remodeling
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9.6MMP13, MMP3, ACAN
59.6BMP7, MMP13, ACAN
6
Hide members
9.3BMP7, COL9A3, COL9A2, COL9A1
7
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9.2COL9A1, COL9A2, COL9A3, CD36
8
Hide members
9.2FBLN1, FBLN2, BMP7
9
Hide members
9.0COL9A1, COL9A2, COL9A3, MMP13, MMP3
10
Hide members
8.6COL9A2, COL9A3, TNR, MATN3, CD36, ACAN
11
Hide members
8.6COL9A1, COL9A2, COL9A3, CD36, MMP13, MMP3
12
Cell adhesion Cell-matrix glycoconjugates
Hide members
8.5TNR, FBLN2, FBLN1, MMP3, ACAN
13
Hide members
6.8ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Compounds for genes affiliated with Osteochondritis Dissecans

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4410.3BMP7, ACAN
21-Methyloxy-4-Sulfone-Benzene1110.2MMP13, MMP3
33-Methylpyridine1110.2MMP13, MMP3
4Hydroxyaminovaline1110.2MMP13, MMP3
5cyanogen bromide4410.2MMP13
6thermolysin4410.1MMP3, MMP13
7chitosan4410.0ACAN, CD36
8uk 3833675910.0MMP13, MMP3
9clodronate44 49 1112.0CD36, MMP13
10gi 254023x5910.0MMP13, MMP3
11gm 60015910.0MMP13, MMP3
12pirfenidone44 5910.9CD36, BMP7
13latanoprost44 1110.9GAPDH, MMP3
14keratan sulfate449.9ACAN, MMP3, CD36
15(4-aminophenyl)mercuric acetate449.9CD36, MMP13, MMP3
16alendronate44 49 1111.8CD36, MMP13, MMP3
17batimastat44 59 1111.8CD36, MMP13, MMP3
18hydroxyapatite449.7BMP7, CD36, MMP13
19doxycycline44 1110.7MMP13, MMP3, NOTCH1
20glucosamine44 11 2411.6ACAN, MMP3, MMP13, CD36
21procollagen449.6ACAN, MMP3, MMP13, CD36
22prednisolone44 28 1111.6MMP3, MMP13, GAPDH
23glycosaminoglycan449.6CD36, MMP13, MMP3, ACAN
24hyaluronic acid44 2410.6ACAN, MMP3, MMP13, CD36
25safranin o449.6ACAN, MMP3, CD36, BMP7
26sb 20358044 5910.5CD36, MMP13, MMP3, ACAN
27serine449.5MMP3, MMP13, BMP7
28dexamethasone44 49 28 1112.5BMP7, MMP13, NOTCH1, ACAN
29glyceraldehyde 3-phosphate449.5ACAN, MMP3, MMP13, GAPDH
30agarose449.4ACAN, MMP13, GAPDH, BMP7
31vitamin d449.4ACAN, MMP3, CD36, BMP7
32pyridinoline449.4MMP3, CD36
33neurocan449.3TNR, FBLN2, FBLN1, ACAN
34ribonucleic acid449.3MMP3, MMP13, GAPDH, BMP7
35alginate449.3BMP7, CD36, MMP13, MMP3, ACAN
36tgf beta1449.3BMP7, CD36, MMP13, MMP3, ACAN
37creatinine449.2BMP7, CD36, MMP3
38glutamine449.2COL9A2, GAPDH, CD36, MMP3
39genistein44 28 59 2 11 2414.2CD36, MMP13, MMP3, NOTCH1
40chondroitin sulfate44 2410.2TNR, CD36, MMP13, MMP3, ACAN
41cycloheximide448.9BMP7, GAPDH, CD36, MMP13, MMP3
42ascorbic acid44 249.8BMP7, GAPDH, CD36, MMP13, MMP3, ACAN
43pge2448.7BMP7, GAPDH, CD36, MMP13, MMP3, ACAN
44matrigel448.7FBLN1, CD36, MMP13, MMP3, NOTCH1
45oxygen44 249.5BMP7, GAPDH, MMP13, MMP3, NOTCH1
46vegf448.4BMP7, GAPDH, CD36, MMP13, MMP3, NOTCH1
47retinoic acid44 249.2BMP7, GAPDH, CD36, MMP13, MMP3, NOTCH1
48heparin44 28 11 2411.1BMP7, GAPDH, FBLN2, FBLN1, CD36, MMP13
49estrogen447.8BMP7, GAPDH, FBLN1, CD36, MMP13, MMP3
50calcium44 49 11 2410.3TNR, BMP7, FBLN2, FBLN1, MATN3, CD36

GO Terms for genes affiliated with Osteochondritis Dissecans

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Sources:
16Gene Ontology
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Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6COL9A3, COL9A2, COL9A1
2collagen type IXGO:0055949.5COL9A3, COL9A2, COL9A1
3extracellular matrixGO:0310129.0FBLN2, FBLN1, ACAN
4proteinaceous extracellular matrixGO:0055788.0TNR, FBLN2, FBLN1, MATN3, MMP13, MMP3
5extracellular regionGO:0055766.3ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:20001219.6CD36, BMP7
2branching morphogenesis of an epithelial tubeGO:0487549.6NOTCH1, BMP7
3skeletal system developmentGO:0015019.4COL9A2, BMP7, MATN3, ACAN
4negative regulation of neurogenesisGO:0507689.3NOTCH1, BMP7
5collagen catabolic processGO:0305749.2COL9A1, COL9A2, COL9A3, MMP13, MMP3
6extracellular matrix disassemblyGO:0226179.1COL9A1, COL9A2, COL9A3, MMP13, MMP3
7axon guidanceGO:0074118.9BMP7, TNR, COL9A3, COL9A2, COL9A1
8extracellular matrix organizationGO:0301987.0ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.5COL9A3, COL9A2, COL9A1
2extracellular matrix structural constituentGO:0052018.8FBLN2, FBLN1, MATN3, ACAN
3calcium ion bindingGO:0055098.4NOTCH1, MMP3, MMP13, FBLN1, FBLN2

Products for genes affiliated with Osteochondritis Dissecans

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Osteochondritis Dissecans

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet