MCID: OST009
MIFTS: 59

Osteochondritis Dissecans malady

Genetic diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Osteochondritis Dissecans, Aliases & Descriptions:

Name: Osteochondritis Dissecans 30 9 41 11 47 60
Aseptic Necrosis 41 60
Kônig Disease 41 47
Od 41 3
 
Familial Osteochondritis Dissecans 60
Obsessive-Compulsive Disorder 60
Ocd 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases
Orphanet: 47 
Rare bone diseases


Characteristics (Orphanet epidemiological data):

47
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:84
MeSH33 D010007
NCIt38 C34877
Orphanet47 2764
MESH via Orphanet34 D010008
ICD10 via Orphanet26 M93.2
UMLS via Orphanet61 C0029421
ICD1025 M93.2

Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:41 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary: Osteochondritis Dissecans, also known as aseptic necrosis, is related to stickler syndrome and multiple epiphyseal dysplasia. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Gastric cancer network 2 and Elastic fibre formation. The drugs venlafaxine and venlafaxine hydrochloride and the compounds neurocan and chitosan have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:9 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:3 This content has moved to our new web site, www.cdc.gov/DrugOverdose. You will be automatically redirected there now.

Wikipedia:63 Osteochondritis dissecans /??sti.o?k?n?dra?t?s ?d?s?k more...

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1stickler syndrome31.1COL9A1, COL9A2
2multiple epiphyseal dysplasia30.6MATN3, ACAN, COL9A2, COL9A3, COL9A1
3arthritis30.4ACAN, MMP3
4osteoarthritis28.7MATN3, COL9A1, COL9A3, COL9A2, BMP7, ACAN
5familial osteochondritis dissecans11.0
6obsessive-compulsive disorder10.8
7osteochondrosis10.7
8osteochondritis dissecans, short stature, and early-onset osteoarthritis10.7
9osteochondrodysplasia10.5
10spondyloepimetaphyseal dysplasia10.5MATN3
11legg-calve-perthes disease10.5
12periostitis10.5
13spondylitis10.5ACAN
14spinal stenosis10.5BMP7
15osteonecrosis10.4
16spondylolisthesis10.4BMP7
17degenerative disc disease10.4ACAN, COL9A3
18pandas10.4
19intervertebral disc disease10.3COL9A2, COL9A3
20wilson disease10.3
21rickets10.3
22osgood-schlatter's disease10.3
23myopathy10.3
24dwarfism10.3
25kienbock's disease10.3
26osteoarthropathy of fingers familial10.3
27osteochondritis of tarsal/metatarsal bone10.3
28idiopathic avascular necrosis10.3
29panner disease10.3
30skeletal dysplasia multi-gene panels10.2ACAN, MMP13
31diastrophic dysplasia10.2MATN3, COL9A3, COL9A2
32gaucher disease, type i10.2
33thalassemia10.2
34gaucher's disease10.2
35cushing's syndrome10.2
36chronic ulcer of skin10.2CD36, MMP13
37abdominal aortic aneurysm10.1MMP3, MMP13
38epidermolysis bullosa dystrophica10.1MMP3, CD36
39trichotillomania10.1
40gilles de la tourette syndrome10.1
41panic disorder10.1
42agoraphobia10.1
43pathological gambling10.1
44anxiety disorder10.1
45synovitis10.1MMP3, ACAN, MMP13
46ehlers-danlos syndrome10.1CD36, TNR
47renal osteodystrophy10.1CD36, BMP7
48gingival overgrowth10.1MMP3, CD36
49secondary hyperparathyroidism of renal origin10.1BMP7, CD36
50multiple epiphyseal dysplasia, dominant10.1COL9A2, COL9A1, MATN3, COL9A3

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Drugs & Therapeutics for Osteochondritis Dissecans

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Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

31
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

14
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6FBLN1, MMP13, ACAN, BMP7, COL9A1, MATN3
2MP:00053778.4FBLN1, ACAN, BMP7, COL9A1, NOTCH1
3MP:00053677.7FBLN1, BMP7, GAPDH, NOTCH1, CD36
4MP:00053857.1FBLN1, FBLN2, MMP13, ACAN, BMP7, GAPDH
5MP:00053877.0FBLN1, MMP3, ACAN, BMP7, COL9A1, MATN3
6MP:00053767.0MMP3, ACAN, COL9A1, GAPDH, NOTCH1, CD36
7MP:00036317.0FBLN1, TNR, MMP3, ACAN, BMP7, NOTCH1
8MP:00053786.8FBLN1, MMP13, ACAN, BMP7, MATN3, GAPDH
9MP:00053906.7CD36, FBLN1, MMP13, MMP3, ACAN, BMP7

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Treatment algorithm for osteochondritis dissecans of the knee. (25435043)
2015
2
Osteochondritis dissecans of the knee. (25606539)
2014
3
Bilateral Wrisberg discoid menisci mimicking bucket handle tears associated with osteochondritis dissecans: case report. (25171571)
2014
4
Radiographic diagnosis of osteochondritis dissecans of the temporomandibular joint: two cases. (25012532)
2014
5
State of the art: Elbow arthroscopy: review of the literature and application for osteochondritis dissecans of the capitellum. (25264040)
2014
6
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
7
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
8
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
9
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
10
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
11
Bioabsorbable fixation of unstable osteochondritis dissecans lesions. (20595548)
2010
12
Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy. (20358595)
2010
13
Case report: Fresh-stored osteochondral allograft for treatment of osteochondritis dissecans the femoral head. (19727986)
2010
14
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
15
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
16
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
17
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
18
Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. (20594080)
2010
19
Midterm results of surgical treatment for adult osteochondritis dissecans of the knee. (19861695)
2009
20
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
21
The healing potential of stable juvenile osteochondritis dissecans knee lesions. (19047711)
2008
22
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
23
Intraoperative acoustic evaluation of living human cartilage of the elbow and knee during mosaicplasty for osteochondritis dissecans of the elbow: an in vivo study. (18796577)
2008
24
Osteochondritis dissecans of the tarsal navicular. (18442463)
2008
25
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
26
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
27
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
28
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
29
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
30
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
31
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
32
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
33
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
34
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
35
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
36
Closed-Wedge osteotomy for osteochondritis dissecans of the capitellum. A 7- to 12-year follow-up. (10921645)
2000
37
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
38
Osteochondritis dissecans in a young pitcher: why early recognition matters. (20086894)
1997
39
Osteochondritis dissecans of the distal femur and patella. (9012566)
1997
40
Osteochondritis dissecans of the knee. (20086997)
1996
41
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
42
Osteochondritis dissecans of the anterior tibial spine. (8305108)
1993
43
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
44
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
45
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
46
Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography. (2605451)
1989
47
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
48
Familial osteochondritis dissecans of the knee. (477064)
1979
49
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
50
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960

Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8COL9A1, COL9A3
2
Show member pathways
9.5BMP7, FBLN2, FBLN1
3
Show member pathways
9.4COL9A2, COL9A1, COL9A3
49.4COL9A1, COL9A3, COL9A2
59.4COL9A1, COL9A3, COL9A2
69.4MMP13, ACAN, BMP7
7
Show member pathways
Metalloproteases in connective tissue degradation
9.3MMP13, MMP3, ACAN
8
Show member pathways
9.0COL9A3, COL9A1, COL9A2, BMP7
98.9ACAN, FBLN2, TNR, FBLN1, MMP3
108.6TNR, MATN3, COL9A1, ACAN, COL9A3, COL9A2
11
Show member pathways
8.5MMP13, MMP3, COL9A3, COL9A1, COL9A2
12
Show member pathways
8.3MMP3, NOTCH1, MMP13, BMP7
13
Show member pathways
8.2COL9A1, NOTCH1, COL9A3, BMP7, COL9A2
14
Show member pathways
8.0CD36, COL9A3, COL9A2, NOTCH1, COL9A1
15
Show member pathways
7.9MMP3, MMP13, COL9A2, COL9A1, CD36, COL9A3
16
Show member pathways
6.7MATN3, TNR, MMP13, MMP3, ACAN, FBLN2

Compounds for genes affiliated with Osteochondritis Dissecans

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Compounds related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1neurocan439.9ACAN, TNR, FBLN2, FBLN1
2chitosan439.8ACAN, CD36
3thermolysin439.8MMP13, MMP3
4latanoprost43 1210.8MMP3, GAPDH
5uk 383367599.7MMP13, MMP3
6clodronate43 49 1211.7CD36, MMP13
7gi 254023x599.7MMP13, MMP3
8pirfenidone43 5910.6CD36, BMP7
9gm 6001599.6MMP13, MMP3
10polyglycolic acid439.6ACAN, BMP7, CD36
11sulfonamide439.5MMP3, MMP13
12keratan sulfate439.5CD36, ACAN, MMP3
13cyanogen bromide439.4CD36, MMP13
14(4-aminophenyl)mercuric acetate439.3CD36, MMP3, MMP13
15hydroxyapatite439.3CD36, BMP7, MMP13
16prednisolone43 28 1211.3MMP13, MMP3, GAPDH
17alendronate43 49 1211.3MMP13, MMP3, CD36
18batimastat43 59 1211.3MMP13, MMP3, CD36
19agarose439.2MMP13, ACAN, BMP7, GAPDH
20glyceraldehyde 3-phosphate439.2GAPDH, ACAN, MMP3, MMP13
21glucosamine43 24 1211.1MMP13, MMP3, ACAN, CD36
22procollagen439.1MMP13, MMP3, ACAN, CD36
23glycosaminoglycan439.1CD36, ACAN, MMP3, MMP13
24safranin o439.1CD36, BMP7, ACAN, MMP3
25doxycycline43 1210.1NOTCH1, MMP3, MMP13
26hyaluronic acid43 2410.1CD36, ACAN, MMP3, MMP13
27pyridinoline439.0CD36, MMP3
28sb 20358043 5910.0MMP13, MMP3, ACAN, CD36
29nacl439.0MMP13, MMP3, BMP7
30dmso439.0CD36, GAPDH, MMP3
31vitamin d439.0MMP3, ACAN, BMP7, CD36
32ribonucleic acid438.9MMP13, MMP3, BMP7, GAPDH
33chondroitin sulfate43 249.8TNR, MMP13, MMP3, ACAN, CD36
34glutamine438.8CD36, GAPDH, COL9A2, MMP3
35alginate438.7MMP13, MMP3, ACAN, BMP7, CD36
36tgf beta1438.7MMP13, MMP3, ACAN, BMP7, CD36
37creatinine438.6CD36, GAPDH, BMP7, MMP3
38genistein43 28 59 2 24 1213.4CD36, NOTCH1, MMP3, MMP13
39cycloheximide438.3MMP13, MMP3, BMP7, GAPDH, CD36
40matrigel438.3FBLN1, MMP13, MMP3, NOTCH1, CD36
41ascorbic acid43 249.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
42pge2438.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
43oxygen43 249.0MMP13, MMP3, BMP7, GAPDH, NOTCH1
44heparin43 28 24 1210.9FBLN1, FBLN2, MMP13, MMP3, BMP7, GAPDH
45dexamethasone43 49 28 1210.8MMP13, MMP3, ACAN, BMP7, NOTCH1, CD36
46vegf437.5MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
47serine437.4MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
48retinoic acid43 248.3MMP13, MMP3, ACAN, BMP7, GAPDH, NOTCH1
49estrogen437.3FBLN1, MMP13, MMP3, BMP7, GAPDH, NOTCH1
50calcium43 49 24 1210.0FBLN1, FBLN2, TNR, MMP13, MMP3, BMP7

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.4COL9A1, COL9A3, COL9A2
2collagen type IXGO:00055949.3COL9A1, COL9A3, COL9A2
3extracellular matrixGO:00310129.0FBLN1, FBLN2, ACAN, BMP7
4proteinaceous extracellular matrixGO:00055788.2FBLN1, FBLN2, TNR, MMP13, MMP3, ACAN
5extracellular regionGO:00055765.9NOTCH1, FBLN1, FBLN2, TNR, MMP13, MMP3

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:020001219.5BMP7, CD36
2skeletal system developmentGO:00015019.3MATN3, COL9A2, BMP7, ACAN
3proteolysisGO:00065089.2ACAN, MMP13, MMP3
4negative regulation of neurogenesisGO:00507689.2BMP7, NOTCH1
5epithelial to mesenchymal transitionGO:00018379.2BMP7, NOTCH1
6branching morphogenesis of an epithelial tubeGO:00487548.9BMP7, NOTCH1
7axon guidanceGO:00074118.8TNR, BMP7, COL9A2, COL9A1, COL9A3
8collagen catabolic processGO:00305748.7MMP3, COL9A2, COL9A3, COL9A1, MMP13
9extracellular matrix disassemblyGO:00226178.5MMP13, MMP3, ACAN, COL9A3, COL9A1, COL9A2
10extracellular matrix organizationGO:00301986.9MMP13, MATN3, MMP3, COL9A3, COL9A2, BMP7

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:00300209.3COL9A1, COL9A3, COL9A2
2extracellular matrix structural constituentGO:00052019.1FBLN1, FBLN2, ACAN, MATN3
3calcium ion bindingGO:00055098.2NOTCH1, MMP3, MMP13, FBLN2, FBLN1

Products for genes affiliated with Osteochondritis Dissecans

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Sources for Osteochondritis Dissecans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet