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OD
MCID: OST009
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Osteochondritis Dissecans malady |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 17Genetics Home Reference, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
Genetics Home Reference: Familial osteochondritis dissecans is a condition that affects the joints and is associated with abnormal cartilage. Cartilage is a tough but flexible tissue that covers the ends of the bones at joints and is also part of the developing skeleton. A characteristic feature of familial osteochondritis dissecans is areas of bone damage (lesions) caused by detachment of cartilage and a piece of the underlying bone from the end of the bone at a joint. People with this condition develop multiple lesions that affect several joints, primarily the knees, elbows, hips, and ankles. The lesions cause stiffness, pain, and swelling in the joint. Often, the affected joint feels like it catches or locks during movement. Other characteristic features of familial osteochondritis dissecans include short stature and development of a joint disorder called osteoarthritis at an early age. Osteoarthritis is characterized by the breakdown of joint cartilage and the underlying bone. It causes pain and stiffness and restricts the movement of joints.17
MalaCards: Osteochondritis Dissecans, also known as obsessive-compulsive disorder, is related to epiphyseal dysplasia and multiple sclerosis. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Intrinsic Prothrombin Activation Pathway and Blood Coagulation Cascade. The drugs paroxetine and fluoxetine and the compounds 1-Methyloxy-4-Sulfone-Benzene and 3-Methylpyridine have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, and related mouse phenotypes are limbs/digits/tail and skeleton. Disease Ontology: An ischemic bone disease that results in necrosis located in epiphysis.6 NIH Rare Diseases: In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. The loose piece may stay in place or fall into the joint space, making the joint unstable. This causes pain and feelings that the joint "sticks" or is "giving way." Osteochondritis dissecans usually affects the knees and elbows.30 Wikipedia: Osteochondritis dissecans (pron.: /ˌɒsti.oʊkɒnˈdraɪtɪs ˈdɪsɨkænz/), often abbreviated to OCD...44 more... |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 43UMLS, 33OMIM, 40SNOMED-CT, 27NCIt, 24MeSH See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for osteochondritis dissecans Drug clinical trials:Search ClinicalTrials for osteochondritis dissecans Search NIH Clinical Center for osteochondritis dissecans Search CenterWatch for osteochondritis dissecans Inferred drug relations via UMLS/NDF-RT:43 28 citalopram, citalopram hydrobromide, clomipramine, clomipramine hydrochloride, fluoxetine, fluoxetine hydrochloride, fluvoxamine, fluvoxamine maleate, paroxetine, paroxetine hydrochloride, sertraline, sertraline hydrochloride, venlafaxine, venlafaxine hydrochloride |
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Sources: 11FMA See all sources |
FMA organs/tissues related to osteochondritis dissecans:11Epiphysis
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Sources: 25MGI See all sources |
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Sources: 35PubMed See all sources |
Articles related to osteochondritis dissecans:
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 20KEGG, 38Reactome, 10EMD Millipore, 41Thomson Reuters See all sources |
Pathways related to osteochondritis dissecans according to GeneDecks:(show all 15)
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Sources: 9DrugBank, 32Novoseek , 42Tocris Bioscience, 18HMDB, 34PharmGKB See all sources |
Compounds related to osteochondritis dissecans according to GeneDecks:(show all 42)
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Sources: 12Gene Ontology See all sources |
Cellular components related to osteochondritis dissecans according to GeneDecks:
Biological processes related to osteochondritis dissecans according to GeneDecks:
Molecular functions related to osteochondritis dissecans according to GeneDecks:
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