MCID: OST009
MIFTS: 54

Osteochondritis Dissecans malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 24GTR, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 32 10 45 12 51 36 24 65
Osteochondritis 36 65
König Disease 45 51
 
Obsessive-Compulsive Disorder 65
Kônig Disease 45
Ocd 10

Characteristics:

Orphanet epidemiological data:

51
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:84
ICD1027 M93.2, M93.9
ICD9CM29 732.7
Orphanet51 2764
ICD10 via Orphanet28 M93.2
MESH via Orphanet37 D010008
UMLS via Orphanet66 C0029421
UMLS65 C0029420, C0029421

Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:45 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary: Osteochondritis Dissecans, also known as osteochondritis, is related to familial osteochondritis dissecans and osteochondritis dissecans, short stature, and early-onset osteoarthritis. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways are Gastric cancer network 2 and Protein digestion and absorption. The drugs citalopram and citalopram hydrobromide have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:10 An ischemic bone disease that results in necrosis located in epiphysis.

Wikipedia:68 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

Related Diseases for Osteochondritis Dissecans

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Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Drugs & Therapeutics for Osteochondritis Dissecans

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Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Fibrin Tissue AdhesivePhase 3138
2MitogensPhase 31386
3AstragalusNutraceuticalPhase 348

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1Evaluation of the Agili-C Biphasic Implant in the Knee JointActive, not recruitingNCT01471236Phase 4
2Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)WithdrawnNCT01283737Phase 4
3Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional MicrofractureRecruitingNCT01498029Phase 3
4"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral LesionsRecruitingNCT02005861Phase 3
5ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the KneeActive, not recruitingNCT01458782Phase 2, Phase 3
6Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage DefectsRecruitingNCT01694823Phase 1, Phase 2
7Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
8Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
9Osteochondritis Dissecans of Knee Prospective CohortRecruitingNCT02771496
10Repair of Articular Osteochondral DefectRecruitingNCT01409447
11DeNovo NT Longitudinal Data Collection (LDC) Knee StudyRecruitingNCT01329445
12Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the KneeRecruitingNCT01159899Phase 0
13Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionRecruitingNCT02289976
14DeNovo NT Ankle LDC StudyActive, not recruitingNCT01347892
15Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadActive, not recruitingNCT00813267Phase 0
16Osteochondritis Dissecans of the KneeEnrolling by invitationNCT01455987
17Conjoint Analysis of Patient Preferences in Joint InterventionsNot yet recruitingNCT02664337
18Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the AnkleNot yet recruitingNCT01405664
19Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage RegenerationTerminatedNCT00881023
20Chondrofix Osteochondral Allograft Prospective StudyTerminatedNCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS65/NDF-RT43:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455


Cochrane evidence based reviews: osteochondritis

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

33
Bone, Breast, Bone marrow, Lung, Endothelial, Brain, Liver

FMA organs/tissues related to Osteochondritis Dissecans:

16
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.0BMP7, COL9A1, COL9A2, FBLN1
2MP:00053717.5BMP7, COL9A1, COL9A2, FBLN1, MATN3, MMP13
3MP:00053907.4BMP7, COL9A1, COL9A2, FBLN1, MATN3, MMP13

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography. (25742060)
2015
2
On-Demand Delivery of Influenza Vaccination. (26571249)
2015
3
Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway. (24819335)
2014
4
"Interstitial Lung Disease in Undifferentiated Forms of Connective Tissue Disease" (25048539)
2014
5
Continuous spinal labor analgesia in a patient with Hajdu-Cheney syndrome. (23970057)
2013
6
Staging of Acute Exacerbation in Patients with Idiopathic Pulmonary Fibrosis. (24221341)
2013
7
Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease. (24099467)
2013
8
Aging aggravates long-term renal ischemia-reperfusion injury in a rat model. (24238972)
2013
9
Relationship between gross motor function and daily functional skill in children with cerebral palsy. (23525125)
2013
10
MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. (23468640)
2013
11
Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. (22806758)
2012
12
Lack of association between a functional genetic variant of connexin 37 and ischemic stroke in a Taiwanese population. (22305353)
2012
13
Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients. (22231705)
2012
14
Pyoderma gangrenosum in breast reconstruction. (22747349)
2012
15
Polymorphic variants of genes related to arginine metabolism and the risk of orofacial clefts. (20739017)
2010
16
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. (20566747)
2010
17
Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy. (20954276)
2010
18
Human decay-accelerating factor and CEACAM receptor-mediated internalization and intracellular lifestyle of Afa/Dr diffusely adhering Escherichia coli in epithelial cells. (19015254)
2009
19
Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model. (19460822)
2009
20
Rheumatic fever in a 2-year-old child. (17952489)
2008
21
Monozygous twins with a microdeletion syndrome involving BTK, DDP1, and two other genes; evidence of intact dendritic cell development and TLR responses. (17520285)
2008
22
Adipokines in diabetes and cardiovascular diseases. (17912155)
2007
23
IKK epsilon signaling: not just NF-kappaB. (16890515)
2006
24
Huge primitive neuroectodermal tumor of the pancreas: report of a case and review of the literature. (17009412)
2006
25
A tumor in the medulla oblongata producing beta-HCG and AFP. (16098752)
2005
26
Rhodopsin, violet and blue opsin expressions in the chick are highly dependent on tissue and serum conditions. (16260862)
2005
27
The level of antioxidant enzymes, plasma vitamins C and E in cement plant workers. (14967176)
2004
28
Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. (15304427)
2004
29
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (15148369)
2004
30
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. (15141215)
2004
31
VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx. (15327778)
2004
32
Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells. (12829429)
2003
33
Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. (14688706)
2003
34
Genetics of seasonal affective disorder. (11897319)
2002
35
Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (11925108)
2002
36
Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas. (11764070)
2001
37
The co-ordinated cytokine/hormone response to acute injury incorporates leptin. (10880250)
2000
38
Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. (10365894)
1999
39
Detection of bladder tumor by urine cytology in cases of prostatic hypertrophy. (8989544)
1996
40
Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. (8668331)
1996
41
The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. (7601445)
1995
42
Value of laparoscopy in trauma ICU patients with suspected acute acalculous cholecystitis. (8073348)
1994
43
Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. (8467709)
1993
44
Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies. (8504879)
1993
45
Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation. (2176212)
1990
46
Elevated corneal epithelial lines in Acanthamoeba keratitis. (3046583)
1988
47
Multiple ventricular septal defects. (5009303)
1972
48
Experimental studies on byssinosis. (13803226)
1960
49
Rheumatic fever as a collagen disease. (13339200)
1956
50

Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.8COL9A1, COL9A3
29.4COL9A1, COL9A2, COL9A3
39.4COL9A1, COL9A2, COL9A3
49.1ACAN, BMP7, MMP13
59.0COL9A1, COL9A2, COL9A3, TNR
6
Show member pathways
9.0COL9A1, COL9A2, COL9A3, TNR
7
Show member pathways
9.0COL9A1, COL9A2, COL9A3, TNR
8
Show member pathways
9.0COL9A1, COL9A2, COL9A3, MMP13
9
Show member pathways
8.7ACAN, COL9A1, COL9A2, COL9A3, MMP13
10
Show member pathways
8.5ACAN, BMP7, COL9A1, COL9A2, COL9A3
11
Show member pathways
8.5BMP7, FBLN1, FBLN2
128.4ACAN, FBLN1, FBLN2, TNR
138.2ACAN, COL9A1, COL9A2, COL9A3, MATN3, TNR
14
Show member pathways
5.8ACAN, BMP7, COL9A1, COL9A2, COL9A3, FBLN1

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.6MMP13, TNR
2collagen type IX trimerGO:00055949.1COL9A1, COL9A2, COL9A3

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00015019.7BMP7, COL9A2
2collagen catabolic processGO:00305749.2COL9A1, COL9A3, MMP13
3extracellular matrix disassemblyGO:00226178.7ACAN, COL9A1, COL9A2, COL9A3, MMP13

Sources for Osteochondritis Dissecans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet