OD
MCID: OST009
MIFTS: 60

Osteochondritis Dissecans (OD) malady

Bone category

Summaries for Osteochondritis Dissecans

Sources:
8Disease Ontology, 43NIH Rare Diseases, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. the loose piece may stay in place or fall into the joint space, making the joint unstable. this causes pain and feelings that the joint "sticks" or is "giving way." osteochondritis dissecans usually affects the knees and elbows. last updated: 6/4/2009

MalaCards: Osteochondritis Dissecans, also known as aseptic necrosis, is related to stickler syndrome and multiple epiphyseal dysplasia. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Degradation of collagen and Protein digestion and absorption. The drugs citalopram and citalopram hydrobromide and the compounds polyglycolic acid and Hydroxyaminovaline have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and skeletal muscle, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:3 Deaths from drug overdose have been rising steadily over the past two decades and have become the leading cause of injury death in the United States.1  Every day in the United States, 105 people die as a result of drug overdose, and another 6,748 are treated in emergency departments (ED) for the misuse or abuse of drugs.2 Nearly 9 out of 10 poisoning deaths are caused by drugs.3

Wikipedia:64 Osteochondritis dissecans /ˌɒsti.oʊkɒnˈdraɪtɪs ˈdɪsɨkænz/, often abbreviated to OCD or OD, is... more...

Description from OMIM:47 165800

Aliases & Classifications for Osteochondritis Dissecans

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

osteochondritis dissecans 8 43 10 31 61
aseptic necrosis 43 61
obsessive-compulsive disorder 61
ocd 8
od 43


External Ids:

Disease Ontology8 DOID:84
NCIt40 C34877
OMIM47 165800
MeSH35 D010007
ICD1025 M93.2

Related Diseases for Osteochondritis Dissecans

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteochondritis Dissecans family:

familial osteochondritis dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1stickler syndrome30.5COL9A2, COL9A1
2multiple epiphyseal dysplasia30.5COL9A1, ACAN, MATN3, COL9A3, COL9A2
3osteoarthritis30.5MATN3, COL9A1, COL9A2, COL9A3, BMP7, CD36
4short stature30.3MATN3, CD36
5astrocytoma30.3GAPDH, MMP3
6arthritis30.0MMP3, ACAN
7familial osteochondritis dissecans11.0
8body dysmorphic disorder10.9
9generalized anxiety disorder10.8
10hypochondriasis10.7
11social phobia10.7
12bipolar disorder10.7
13obsessive-compulsive disorder10.7
14anorexia nervosa10.6
15schizotypal personality disorder10.6
16attention deficit hyperactivity disorder10.6
17alexithymia10.6
18tic disorder10.5
19osteonecrosis10.5
20legg-calve-perthes disease10.5
21major depressive disorder10.5
22asperger syndrome10.5
23schizoaffective disorder10.5
24bipolar i disorder10.5
25scurvy10.4
26autistic disorder10.4
27bulimia nervosa10.4
28adjustment disorder10.4
29seasonal affective disorder10.4
30pain disorder10.4
31alcohol dependence10.4
32autism spectrum disorder10.4
33charge syndrome10.4
34myoclonus-dystonia10.4
35myoclonus10.4
36pandas10.3
37carpal tunnel syndrome10.2
38rickets10.2
39wilson disease10.2
40osgood-schlatter's disease10.2
41adult syndrome10.2
42dwarfism10.2
43carpal tunnel syndrome, familial10.2
44panner disease10.2
45parkinson's disease10.2
46transsexualism10.2
47paranoid schizophrenia10.2
48normal pressure hydrocephalus10.2
49narcolepsy10.2
50lateral sclerosis10.2

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Clinical Features for Osteochondritis Dissecans

Sources:
47OMIM
See all sources

Clinical features from OMIM:

165800

Drugs & Therapeutics for Osteochondritis Dissecans

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteochondritis Dissecans

Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Search CenterWatch for Osteochondritis Dissecans

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

Anatomical Context for Osteochondritis Dissecans

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Osteochondritis Dissecans:

33
Skeletal muscle

FMA organs/tissues related to Osteochondritis Dissecans:

14
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Osteochondritis Dissecans

Sources:
51PubMed
See all sources

Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Osteochondritis dissecans development after bone contusion of the knee in the skeletally immature: a case series. (22481267)
2013
2
Three osteochondritis dissecans lesions in one knee: a case report. (22453935)
2013
3
In-vivo biomechanical analysis of osteochondritis dissecans of the humeral trochlea: a case report. (23426027)
2013
4
Clinical outcome and magnetic resonance imaging after osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23413055)
2013
5
Osteochondritis dissecans of the humeral head. (23023034)
2012
6
Osteochondritis dissecans of the capitellum: autologous osteochondral mosaicplasty: a case report. (22980988)
2012
7
Transarticular drilling for stable juvenile osteochondritis dissecans of the medial femoral condyle. (22072323)
2012
8
Elbow arthroscopy: capitellar osteochondritis dissecans and radiocapitellar plica. (21553772)
2011
9
Osteochondritis dissecans (OCD), an endoplasmic reticulum storage disease?: a morphological and molecular study of OCD fragments. (20561273)
2011
10
Arthroscopic management of osteochondritis dissecans of the capitellum: mid-term results in adolescent athletes. (20032735)
2010
11
Fixation of detached osteochondritis dissecans lesions with bioabsorbable pins: clinical and histologic evaluation. (20511036)
2010
12
A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. (20104156)
2009
13
Functional and radiographic outcome of stable juvenile osteochondritis dissecans of the knee treated with retroarticular drilling without bone grafting. (19171273)
2009
14
Sequential alterations in magnetic resonance imaging findings after autologous osteochondral mosaicplasty for young athletes with osteochondritis dissecans of the humeral capitellum. (19726624)
2009
15
Osteochondritis dissecans of the capitellum in fraternal twins: case report. (18929205)
2008
16
Osteochondritis dissecans of the humeral head. (17983832)
2008
17
Osteochondritis dissecans involving the trochlea of the humerus treated with transplantation of tissue-engineered cartilage: a case report. (18396418)
2008
18
Clinical outcome of fragment fixation for osteochondritis dissecans of the elbow. (18509814)
2008
19
Osteochondritis dissecans-like lesion of the intercondylar fossa of the femur in a dog. (18545719)
2008
20
3D imaging (ARCADIS)-based Computer Assisted Surgery (CAS) guided retrograde drilling in osteochondritis dissecans of the talus. (19138491)
2008
21
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
22
Osteochondritis dissecans of the knee. (16467184)
2006
23
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
24
Physical therapist management of an adult with osteochondritis dissecans of the knee. (15982173)
2005
25
A case of osteochondritis dissecans in rickets. (16133607)
2005
26
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
27
Value of micro-CT as an investigative tool for osteochondritis dissecans. (14510761)
2003
28
The use of biodegradables in the treatment of osteochondritis dissecans of the knee: fiction or future? (12769019)
2003
29
Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. (12721341)
2003
30
Transchondral drilling for osteochondritis dissecans of the medial condyle of the knee. (12548449)
2003
31
Drilling from the intercondylar area for treatment of osteochondritis dissecans of the knee joint. (12893148)
2003
32
Osteochondritis dissecans: Wilson's sign revisited. (12975201)
2003
33
Arthroscopic versus conservative treatment of osteochondritis dissecans of the knee: value of magnetic resonance imaging in therapy planning and follow-up. (11951196)
2002
34
Osteochondritis dissecans of the patellofemoral joint. (11206248)
2001
35
Functional and radiographic outcome of juvenile osteochondritis dissecans of the knee treated with transarticular arthroscopic drilling. (11573913)
2001
36
Sonographic assessment of osteochondritis dissecans of the humeral capitellum. (10658717)
2000
37
Osteochondritis dissecans of the elbow: diagnosis, treatment, and prevention. (20086698)
1999
38
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
39
Radiologic case study. Osteochondritis dissecans. (9547826)
1998
40
Antegrade drilling for osteochondritis dissecans of the knee. (9195028)
1997
41
Osteochondritis dissecans of the talus presenting as an ankle ganglion. (9127870)
1997
42
Osteochondritis dissecans of the femoral condyles. Long-term results of excision of the fragment. (9397273)
1997
43
Osteochondritis dissecans. (8613454)
1996
44
Osteochondritis dissecans of the femoral head in children and adolescents: a report of 17 cases. (7790486)
1995
45
Osteochondritis dissecans of the humeral capitellum in children. (8323926)
1993
46
Diet and exercise as potential risk factors for osteochondritis dissecans in dogs. (1466510)
1992
47
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
48
Familial osteochondritis dissecans. (2791462)
1989
49
Osteochondritis dissecans of the dome of the talus. Computed tomography scanning in the diagnosis and follow-up. (2703523)
1989
50
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978

Genetic Variations for Osteochondritis Dissecans

Expression for genes affiliated with Osteochondritis Dissecans

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MMP3, MMP13
29.6COL9A3, COL9A2, COL9A1
3
Hide members
9.6COL9A3, COL9A2, COL9A1
4
Cell adhesion ECM remodeling
Hide members
9.6MMP13, MMP3, ACAN
59.6BMP7, MMP13, ACAN
6
Hide members
9.3BMP7, COL9A3, COL9A2, COL9A1
7
Hide members
9.2COL9A1, COL9A2, COL9A3, CD36
8
Hide members
9.2FBLN1, FBLN2, BMP7
9
Hide members
9.0COL9A1, COL9A2, COL9A3, MMP13, MMP3
10
Hide members
8.6COL9A2, COL9A3, TNR, MATN3, CD36, ACAN
11
Hide members
8.6COL9A1, COL9A2, COL9A3, CD36, MMP13, MMP3
12
Cell adhesion Cell-matrix glycoconjugates
Hide members
8.5TNR, FBLN2, FBLN1, MMP3, ACAN
13
Hide members
6.8ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Compounds for genes affiliated with Osteochondritis Dissecans

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4510.3ACAN, BMP7
2Hydroxyaminovaline1110.2MMP3, MMP13
31-Methyloxy-4-Sulfone-Benzene1110.2MMP13, MMP3
43-Methylpyridine1110.2MMP13, MMP3
5cyanogen bromide4510.2MMP13
6thermolysin4510.1MMP3, MMP13
7chitosan4510.0ACAN, CD36
8uk 3833676010.0MMP13, MMP3
9clodronate45 50 1112.0CD36, MMP13
10gi 254023x6010.0MMP13, MMP3
11gm 60016010.0MMP13, MMP3
12pirfenidone45 6010.9BMP7, CD36
13latanoprost45 1110.9GAPDH, MMP3
14keratan sulfate459.9MMP3, ACAN, CD36
15(4-aminophenyl)mercuric acetate459.9CD36, MMP13, MMP3
16alendronate45 50 1111.8CD36, MMP13, MMP3
17batimastat45 60 1111.8MMP13, CD36, MMP3
18hydroxyapatite459.7BMP7, MMP13, CD36
19doxycycline45 1110.7NOTCH1, MMP3, MMP13
20glucosamine45 11 2411.6ACAN, MMP3, MMP13, CD36
21procollagen459.6CD36, ACAN, MMP3, MMP13
22prednisolone45 29 1111.6MMP13, GAPDH, MMP3
23glycosaminoglycan459.6CD36, ACAN, MMP3, MMP13
24hyaluronic acid45 2410.6MMP13, CD36, MMP3, ACAN
25safranin o459.6BMP7, CD36, MMP3, ACAN
26sb 20358045 6010.5CD36, ACAN, MMP3, MMP13
27serine459.5MMP13, BMP7, MMP3
28dexamethasone45 50 29 1112.5ACAN, MMP13, BMP7, NOTCH1
29glyceraldehyde 3-phosphate459.5ACAN, MMP3, MMP13, GAPDH
30agarose459.4ACAN, GAPDH, BMP7, MMP13
31vitamin d459.4CD36, BMP7, MMP3, ACAN
32pyridinoline459.4MMP3, CD36
33neurocan459.3FBLN2, TNR, ACAN, FBLN1
34ribonucleic acid459.3MMP3, GAPDH, BMP7, MMP13
35alginate459.3CD36, BMP7, ACAN, MMP3, MMP13
36tgf beta1459.3MMP3, ACAN, BMP7, CD36, MMP13
37creatinine459.2BMP7, CD36, MMP3
38glutamine459.2GAPDH, MMP3, CD36, COL9A2
39genistein45 29 60 2 11 2414.2NOTCH1, MMP3, CD36, MMP13
40chondroitin sulfate45 2410.2ACAN, MMP3, MMP13, CD36, TNR
41cycloheximide458.9BMP7, CD36, MMP13, MMP3, GAPDH
42ascorbic acid45 249.8CD36, MMP13, BMP7, GAPDH, MMP3, ACAN
43pge2458.7GAPDH, MMP3, ACAN, MMP13, CD36, BMP7
44matrigel458.7NOTCH1, MMP3, MMP13, CD36, FBLN1
45oxygen45 249.5BMP7, NOTCH1, MMP3, MMP13, GAPDH
46vegf458.4MMP13, MMP3, BMP7, NOTCH1, CD36, GAPDH
47retinoic acid45 249.2ACAN, BMP7, MMP3, MMP13, GAPDH, NOTCH1
48heparin45 29 11 2411.1BMP7, FBLN2, GAPDH, FBLN1, CD36, MMP13
49estrogen457.8MMP13, MMP3, NOTCH1, FBLN1, GAPDH, BMP7
50calcium45 50 11 2410.3CD36, TNR, MMP3, NOTCH1, FBLN2, MMP13

GO Terms for genes affiliated with Osteochondritis Dissecans

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6COL9A3, COL9A2, COL9A1
2collagen type IXGO:0055949.5COL9A3, COL9A2, COL9A1
3extracellular matrixGO:0310129.0FBLN2, FBLN1, ACAN
4proteinaceous extracellular matrixGO:0055788.0TNR, FBLN2, FBLN1, MATN3, MMP13, MMP3
5extracellular regionGO:0055766.3ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:20001219.6CD36, BMP7
2branching morphogenesis of an epithelial tubeGO:0487549.6NOTCH1, BMP7
3skeletal system developmentGO:0015019.4ACAN, COL9A2, BMP7, MATN3
4negative regulation of neurogenesisGO:0507689.3NOTCH1, BMP7
5collagen catabolic processGO:0305749.2MMP13, MMP3, COL9A1, COL9A2, COL9A3
6extracellular matrix disassemblyGO:0226179.1COL9A2, COL9A1, MMP3, MMP13, COL9A3
7axon guidanceGO:0074118.9COL9A2, COL9A1, TNR, BMP7, COL9A3
8extracellular matrix organizationGO:0301987.0FBLN1, ACAN, MMP3, MMP13, MATN3, FBLN2

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.5COL9A3, COL9A2, COL9A1
2extracellular matrix structural constituentGO:0052018.8FBLN2, FBLN1, MATN3, ACAN
3calcium ion bindingGO:0055098.4NOTCH1, MMP3, MMP13, FBLN1, FBLN2

Products for genes affiliated with Osteochondritis Dissecans

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondritis Dissecans

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet