OD
MCID: OST009
MIFTS: 67

Osteochondritis Dissecans (OD) malady

Genetic diseases, Rare diseases, Bone diseases categories
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Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:42 In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. the loose piece may stay in place or fall into the joint space, making the joint unstable. this causes pain and feelings that the joint "sticks" or is "giving way." osteochondritis dissecans usually affects the knees and elbows. last updated: 6/4/2009

MalaCards based summary: Osteochondritis Dissecans, also known as aseptic necrosis, is related to stickler syndrome and short stature. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Gastric cancer network 2 and Elastic fibre formation. The drugs citalopram and citalopram hydrobromide and the compounds neurocan and chitosan have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:3 Deaths from drug overdose have been rising steadily over the past two decades and have become the leading cause of injury death in the United States.1  Every day in the United States, 114 people die as a result of drug overdose1, and another 6,748 are treated in emergency departments (ED) for the misuse or abuse of drugs.2 Nearly 9 out of 10 poisoning deaths are caused by drugs.3

Wikipedia:65 Osteochondritis dissecans /??sti.o?k?n?dra?t?s ?d?s?k more...

Description from OMIM:46 165800

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 46OMIM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Osteochondritis Dissecans, Aliases & Descriptions:

Name: Osteochondritis Dissecans 30 8 42 10 48 62
Aseptic Necrosis 42 62
Obsessive-Compulsive Disorder 62
 
K├┤nig Disease 48
Ocd 8
Od 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases
Orphanet: 48 
Rare bone diseases


Characteristics (Orphanet epidemiological data):

48
osteochondritis dissecans:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:84
OMIM46 165800
NCIt39 C34877
MeSH34 D010007
MESH via Orphanet35 D010008
ICD10 via Orphanet26 M93.2
UMLS via Orphanet63 C0029421
ICD1025 M93.2

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1stickler syndrome31.1COL9A1, COL9A2
2short stature30.7MATN3, CD36
3multiple epiphyseal dysplasia30.6MATN3, ACAN, COL9A2, COL9A3, COL9A1
4arthritis30.4ACAN, MMP3
5osteosarcoma30.0MMP13, BMP7, NOTCH1, CD36
6osteoarthritis28.7MATN3, COL9A1, COL9A3, COL9A2, BMP7, ACAN
7familial osteochondritis dissecans11.0
8obsessive-compulsive disorder10.7
9osteochondrosis10.7
10osteochondrodysplasia10.5
11spondyloepimetaphyseal dysplasia10.5MATN3
12osteonecrosis10.5
13legg-calve-perthes disease10.5
14periostitis10.5
15spondylitis10.5ACAN
16spinal stenosis10.5BMP7
17spondylolisthesis10.4BMP7
18pandas10.4
19degenerative disc disease10.3COL9A2, COL9A3
20lumbar disc disease10.3COL9A2, COL9A3
21wilson disease10.3
22osgood-schlatter's disease10.3
23carpal tunnel syndrome10.3
24rickets10.3
25myopathy10.3
26dwarfism10.3
27kienbock's disease10.3
28osteochondritis of tarsal/metatarsal bone10.3
29thiemann disease, familial form10.3
30panner disease10.3
31skeletal dysplasia multi-gene panels10.2ACAN, MMP13
32diastrophic dysplasia10.2MATN3, COL9A3, COL9A2
33thalassemia10.2
34abdominal aortic aneurysm10.2MMP3, MMP13
35epidermolysis bullosa dystrophica10.1MMP3, CD36
36synovitis10.1MMP3, ACAN, MMP13
37ehlers-danlos syndrome10.1CD36, TNR
38agoraphobia10.1
39panic disorder10.1
40trichotillomania10.1
41pathological gambling10.1
42anxiety disorder10.1
43obsessive-compulsive disorder, protection against10.1
44renal osteodystrophy10.1CD36, BMP7
45gingival overgrowth10.1MMP3, CD36
46secondary hyperparathyroidism of renal origin10.1BMP7, CD36
47multiple epiphyseal dysplasia, dominant10.1COL9A2, COL9A1, MATN3, COL9A3
48pseudoachondroplasia10.1COL9A1, COL9A2, MATN3, COL9A3
49crohn's disease10.1
50gaucher's disease10.1

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Clinical features from OMIM:

165800

Drugs & Therapeutics for Osteochondritis Dissecans

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Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

32
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

14
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6FBLN1, MMP13, ACAN, BMP7, COL9A1, MATN3
2MP:00053778.4FBLN1, ACAN, BMP7, COL9A1, NOTCH1
3MP:00053677.7FBLN1, BMP7, GAPDH, NOTCH1, CD36
4MP:00053857.1FBLN1, FBLN2, MMP13, ACAN, BMP7, GAPDH
5MP:00053877.0FBLN1, MMP3, ACAN, BMP7, COL9A1, MATN3
6MP:00053767.0MMP3, ACAN, COL9A1, GAPDH, NOTCH1, CD36
7MP:00036317.0FBLN1, TNR, MMP3, ACAN, BMP7, NOTCH1
8MP:00053786.8FBLN1, MMP13, ACAN, BMP7, MATN3, GAPDH
9MP:00053906.7CD36, FBLN1, MMP13, MMP3, ACAN, BMP7

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Bilateral Wrisberg discoid menisci mimicking bucket handle tears associated with osteochondritis dissecans: case report. (25171571)
2014
2
Radiographic diagnosis of osteochondritis dissecans of the temporomandibular joint: two cases. (25012532)
2014
3
State of the art: Elbow arthroscopy: review of the literature and application for osteochondritis dissecans of the capitellum. (25264040)
2014
4
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
5
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
6
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
7
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
8
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
9
Bioabsorbable fixation of unstable osteochondritis dissecans lesions. (20595548)
2010
10
Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy. (20358595)
2010
11
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
12
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
13
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
14
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
15
Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. (20594080)
2010
16
Midterm results of surgical treatment for adult osteochondritis dissecans of the knee. (19861695)
2009
17
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
18
The healing potential of stable juvenile osteochondritis dissecans knee lesions. (19047711)
2008
19
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
20
Intraoperative acoustic evaluation of living human cartilage of the elbow and knee during mosaicplasty for osteochondritis dissecans of the elbow: an in vivo study. (18796577)
2008
21
Osteochondritis dissecans of the tarsal navicular. (18442463)
2008
22
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
23
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
24
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
25
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
26
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
27
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
28
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
29
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
30
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
31
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
32
Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. (11536094)
2001
33
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
34
Osteochondral grafting and arthroplasty for end-stage osteochondritis dissecans of the capitellum. A case report and review of the literature. (11573926)
2001
35
Closed-Wedge osteotomy for osteochondritis dissecans of the capitellum. A 7- to 12-year follow-up. (10921645)
2000
36
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
37
Osteochondritis dissecans in a young pitcher: why early recognition matters. (20086894)
1997
38
Osteochondritis dissecans of the distal femur and patella. (9012566)
1997
39
Osteochondritis dissecans of the knee. (20086997)
1996
40
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
41
Osteochondritis dissecans of the anterior tibial spine. (8305108)
1993
42
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
43
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
44
Injuries to the talus-neck fractures and osteochondral lesions (osteochondritis dissecans). (1875012)
1991
45
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
46
Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography. (2605451)
1989
47
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
48
Familial osteochondritis dissecans of the knee. (477064)
1979
49
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
50
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960

Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Expression patterns in normal tissues for genes affiliated with Osteochondritis Dissecans

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Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8COL9A1, COL9A3
2
Show member pathways
9.5BMP7, FBLN2, FBLN1
3
Show member pathways
9.4COL9A2, COL9A1, COL9A3
49.4COL9A1, COL9A3, COL9A2
59.4COL9A1, COL9A3, COL9A2
69.4MMP13, ACAN, BMP7
7
Show member pathways
9.3MMP13, MMP3, ACAN
8
Show member pathways
9.0COL9A3, COL9A1, COL9A2, BMP7
98.9ACAN, FBLN2, TNR, FBLN1, MMP3
108.6TNR, MATN3, COL9A1, ACAN, COL9A3, COL9A2
11
Show member pathways
8.5MMP13, MMP3, COL9A3, COL9A1, COL9A2
12
Show member pathways
8.3MMP3, NOTCH1, MMP13, BMP7
13
Show member pathways
8.2COL9A1, NOTCH1, COL9A3, BMP7, COL9A2
14
Show member pathways
8.0CD36, COL9A3, COL9A2, NOTCH1, COL9A1
15
Show member pathways
7.9MMP3, MMP13, COL9A2, COL9A1, CD36, COL9A3
16
Show member pathways
6.7MATN3, TNR, MMP13, MMP3, ACAN, FBLN2

Compounds for genes affiliated with Osteochondritis Dissecans

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Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1neurocan449.9ACAN, TNR, FBLN2, FBLN1
2chitosan449.8ACAN, CD36
3thermolysin449.8MMP13, MMP3
4latanoprost44 1110.8MMP3, GAPDH
5uk 383367619.7MMP13, MMP3
6clodronate44 50 1111.7CD36, MMP13
7gi 254023x619.7MMP13, MMP3
8pirfenidone44 6110.6CD36, BMP7
9gm 6001619.6MMP13, MMP3
10polyglycolic acid449.6ACAN, BMP7, CD36
11sulfonamide449.5MMP3, MMP13
12keratan sulfate449.5CD36, ACAN, MMP3
13cyanogen bromide449.4CD36, MMP13
14(4-aminophenyl)mercuric acetate449.3CD36, MMP3, MMP13
15hydroxyapatite449.3CD36, BMP7, MMP13
16prednisolone44 28 1111.3MMP13, MMP3, GAPDH
17alendronate44 50 1111.3MMP13, MMP3, CD36
18batimastat44 61 1111.3MMP13, MMP3, CD36
19agarose449.2MMP13, ACAN, BMP7, GAPDH
20glyceraldehyde 3-phosphate449.2GAPDH, ACAN, MMP3, MMP13
21glucosamine44 24 1111.1MMP13, MMP3, ACAN, CD36
22procollagen449.1MMP13, MMP3, ACAN, CD36
23glycosaminoglycan449.1CD36, ACAN, MMP3, MMP13
24safranin o449.1CD36, BMP7, ACAN, MMP3
25doxycycline44 1110.1NOTCH1, MMP3, MMP13
26hyaluronic acid44 2410.1CD36, ACAN, MMP3, MMP13
27pyridinoline449.0CD36, MMP3
28sb 20358044 6110.0MMP13, MMP3, ACAN, CD36
29nacl449.0MMP13, MMP3, BMP7
30dmso449.0CD36, GAPDH, MMP3
31vitamin d449.0MMP3, ACAN, BMP7, CD36
32ribonucleic acid448.9MMP13, MMP3, BMP7, GAPDH
33chondroitin sulfate44 249.8TNR, MMP13, MMP3, ACAN, CD36
34glutamine448.8CD36, GAPDH, COL9A2, MMP3
35alginate448.7MMP13, MMP3, ACAN, BMP7, CD36
36tgf beta1448.7MMP13, MMP3, ACAN, BMP7, CD36
37creatinine448.6CD36, GAPDH, BMP7, MMP3
38genistein44 28 61 2 24 1113.4CD36, NOTCH1, MMP3, MMP13
39cycloheximide448.3MMP13, MMP3, BMP7, GAPDH, CD36
40matrigel448.3FBLN1, MMP13, MMP3, NOTCH1, CD36
41ascorbic acid44 249.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
42pge2448.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
43oxygen44 249.0MMP13, MMP3, BMP7, GAPDH, NOTCH1
44heparin44 28 24 1110.9FBLN1, FBLN2, MMP13, MMP3, BMP7, GAPDH
45dexamethasone44 50 28 1110.8MMP13, MMP3, ACAN, BMP7, NOTCH1, CD36
46vegf447.5MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
47serine447.4MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
48retinoic acid44 248.3MMP13, MMP3, ACAN, BMP7, GAPDH, NOTCH1
49estrogen447.3FBLN1, MMP13, MMP3, BMP7, GAPDH, NOTCH1
50calcium44 50 24 1110.0FBLN1, FBLN2, TNR, MMP13, MMP3, BMP7

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.4COL9A1, COL9A3, COL9A2
2collagen type IXGO:0055949.3COL9A1, COL9A3, COL9A2
3extracellular matrixGO:0310129.0FBLN1, FBLN2, ACAN, BMP7
4proteinaceous extracellular matrixGO:0055788.2FBLN1, FBLN2, TNR, MMP13, MMP3, ACAN
5extracellular regionGO:0055765.9NOTCH1, FBLN1, FBLN2, TNR, MMP13, MMP3

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:20001219.5BMP7, CD36
2skeletal system developmentGO:0015019.3MATN3, COL9A2, BMP7, ACAN
3proteolysisGO:0065089.2MMP13, MMP3, ACAN
4negative regulation of neurogenesisGO:0507689.2NOTCH1, BMP7
5epithelial to mesenchymal transitionGO:0018379.2NOTCH1, BMP7
6branching morphogenesis of an epithelial tubeGO:0487548.9NOTCH1, BMP7
7axon guidanceGO:0074118.8TNR, BMP7, COL9A2, COL9A3, COL9A1
8collagen catabolic processGO:0305748.7MMP13, MMP3, COL9A2, COL9A3, COL9A1
9extracellular matrix disassemblyGO:0226178.5MMP13, MMP3, ACAN, COL9A2, COL9A3, COL9A1
10extracellular matrix organizationGO:0301986.9MATN3, FBLN1, FBLN2, TNR, MMP13, MMP3

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.3COL9A1, COL9A3, COL9A2
2extracellular matrix structural constituentGO:0052019.1FBLN1, FBLN2, ACAN, MATN3
3calcium ion bindingGO:0055098.2NOTCH1, MMP3, MMP13, FBLN2, FBLN1

Products for genes affiliated with Osteochondritis Dissecans

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  • Antibodies
  • Proteins
  • Lysates

Sources for Osteochondritis Dissecans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet