OCD
MCID: OST009
MIFTS: 49

Osteochondritis Dissecans (OCD) malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
11Disease Ontology, 13DISEASES, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 35LifeMap Discovery®, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 35 11 48 54 27 39 13 68
Osteochondritis 39 68
König Disease 48 54
 
Ocd 11 13
Kônig Disease 48

Characteristics:

Orphanet epidemiological data:

54
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:84
ICD1030 M93.2, M93.9
ICD9CM32 732.7
Orphanet54 ORPHA2764
ICD10 via Orphanet31 M93.2
MESH via Orphanet40 D010008
UMLS via Orphanet69 C0029421

Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:48 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary: Osteochondritis Dissecans, also known as osteochondritis, is related to osteonecrosis and familial osteochondritis dissecans. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways are Gastric Cancer Network 2 and Articular Cartilage Extracellular Matrix Pathway. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:11 An ischemic bone disease that results in necrosis located in epiphysis.

Wikipedia:71 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis29.4ACAN, COL9A1, COMP, MATN3, MMP13
2familial osteochondritis dissecans12.7
3osteochondritis dissecans, short stature, and early-onset osteoarthritis12.6
4obsessive-compulsive disorder11.6
5pandas11.1
6trichotillomania11.1
7gilles de la tourette syndrome11.1
8idiopathic avascular necrosis11.1
9osteochondrosis10.4
10legg-calve-perthes disease10.2
11periostitis10.2
12cerebral beriberi10.1COL9A2, COL9A3
13cerebral palsy10.1ACAN, COMP
14epiphyseal dysplasia, multiple, with myopia and deafness10.1ACAN, COMP
15vulvar sarcoma10.1ACAN, COMP
16thiemann disease10.1
17kohler's disease10.1
18osgood-schlatter's disease10.1
19kienbock's disease10.1
20sp7-related osteogenesis imperfecta10.1ACAN, COMP
21osteoarthritis10.1
22stickler syndrome10.1
23multiple epiphyseal dysplasia10.1
24vitelliform macular dystrophy10.1COL9A2, COMP
25albright's hereditary osteodystrophy10.0ACAN, COMP
26familial thoracic aortic aneurysm and dissection10.0ACAN, FBLN1, FBLN2, TNR
27mild hemophilia a10.0COL9A1, COL9A2, COL9A3
28maternally-inherited mitochondrial dystonia10.0COL9A1, COL9A2, COL9A3
29charcot-marie-tooth disease type 510.0COL9A1, COL9A2, COL9A3
30slti salem syndrome10.0COMP, MATN3
31dentin dysplasia10.0ACAN, COL9A3, MMP13
32stickler syndrome, type v9.9COL9A2, COL9A3
33wilson disease9.9
34spondyloepiphyseal dysplasia tarda9.9
35rickets9.9
36myopathy9.9
37dwarfism9.9
38short stature, optic nerve atrophy, and pelger-huet anomaly9.9ACAN, MATN3, MMP13
39bone structure disease9.9COL9A2, COMP, MATN3
40bone angioendothelial sarcoma9.9ACAN, COMP, MMP13
41neuropathy, distal hereditary motor, type iia9.9COMP, MMP13
42myopia, x-linked9.6COL9A1, COL9A2, COL9A3, COMP, MATN3
43syngnathia cleft palate9.6ACAN, BMP7, COL9A1, COL9A2, COL9A3
44bone resorption disease9.5ACAN, BMP7, COL9A2, COL9A3, MMP13
45physical disorder9.5ACAN, BMP7, COL9A2, COL9A3, MMP13
46immunodeficiency 309.5ACAN, COL9A1, COL9A2, COL9A3, COMP, MATN3
47intermediate uveitis9.5ACAN, COL9A1, COL9A2, COL9A3, COMP, MATN3
48osteopetrosis8.6ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms & Phenotypes for Osteochondritis Dissecans

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MGI Mouse Phenotypes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.5BMP7, COL9A1, COL9A2, FBLN1
2MP:00053717.7BMP7, COL9A1, COL9A2, COMP, FBLN1, MATN3
3MP:00053907.0BMP7, COL9A1, COL9A2, COMP, FBLN1, MATN3

Drugs & Therapeutics for Osteochondritis Dissecans

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Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Fibrin Tissue AdhesivePhase 3148
2MitogensPhase 31617
3AstragalusNutraceutical55

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)WithdrawnNCT01283737Phase 4
2Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional MicrofractureUnknown statusNCT01498029Phase 3
3A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects.CompletedNCT02993510Phase 3
4ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the KneeActive, not recruitingNCT01458782Phase 2, Phase 3
5Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage DefectsUnknown statusNCT01694823Phase 1, Phase 2
6Osteochondritis Dissecans of the KneeUnknown statusNCT01455987
7Repair of Articular Osteochondral DefectUnknown statusNCT01409447
8Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the AnkleUnknown statusNCT01405664
9Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadUnknown statusNCT00813267Early Phase 1
10Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the KneeUnknown statusNCT01159899Early Phase 1
11Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionUnknown statusNCT02289976
12Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
13Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
14Osteochondritis Dissecans of Knee Prospective CohortRecruitingNCT02771496
15"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral LesionsRecruitingNCT02005861
16Conjoint Analysis of Patient Preferences in Joint InterventionsRecruitingNCT02664337
17Evaluation of the Agili-C Biphasic Implant in the Knee JointActive, not recruitingNCT01471236
18DeNovo NT Longitudinal Data Collection (LDC) Knee StudyActive, not recruitingNCT01329445
19DeNovo NT Ankle LDC StudyActive, not recruitingNCT01347892
20Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage RegenerationTerminatedNCT00881023
21Chondrofix Osteochondral Allograft Prospective StudyTerminatedNCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455


Cochrane evidence based reviews: osteochondritis

Genetic Tests for Osteochondritis Dissecans

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Genetic tests related to Osteochondritis Dissecans:

id Genetic test Affiliating Genes
1 Osteochondritis Dissecans27

Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

36
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

17
Epiphysis

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 625)
idTitleAuthorsYear
1
Radiographic comparison of adolescent athletes with elbow osteochondritis dissecans to ulnar collateral ligament injuries and controls. (28087165)
2017
2
Osteochondritis dissecans located on the medial tibial plateau: a case report. (28049517)
2017
3
Osteochondritis Dissecans of the Capitellum: Diagnosis and Treatment. (26977547)
2016
4
Mosaicplasty for femoral osteochondritis dissecans. (26896409)
2016
5
Arthroscopic Autologous Chondrocyte Transplantation for Osteochondritis Dissecans of theA Elbow. (27656389)
2016
6
Arthroscopy of the Dorsal and Plantar Pouches of the Tarsocrural Joint for the Treatment of Osteochondritis Dissecans in the Horse: Clinical Features and Follow-Up. (27684059)
2016
7
Osteochondritis dissecans of the capitellum in adolescents. (26925381)
2016
8
Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? (27600715)
2016
9
Catcher's Knee: Posterior Femoral Condyle Juvenile Osteochondritis Dissecans in Children and Adolescents. (27442212)
2016
10
Bone-peg grafting for osteochondritis dissecans of the humeral capitellum. (27122513)
2016
11
The Incidence of Osteochondritis Dissecans in Adolescents Complaining of Chronic Anterior Knee Pain: 2351 Board #5. (27584430)
2016
12
Fresh osteochondral allograft transplantation for osteochondritis dissecans of the capitellum in baseball players. (27742247)
2016
13
Erratum to: Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? (27757802)
2016
14
Novel Arthroscopic Classification of Osteochondritis Dissecans of the Knee: A Multicenter Reliability Study. (27159302)
2016
15
Osteochondritis dissecans on the medial aspect of the humeral head. (27186062)
2016
16
Return to Sport After Operative Management of Osteochondritis Dissecans of the Capitellum: A Systematic Review and Meta-analysis. (27482526)
2016
17
Osteochondritis Dissecans of the Humeral Capitellum Associated with a Large Subchondral Bone Cyst: Two Cases Report. (27454643)
2016
18
Viability of Cells From Displaced Fragments of the Elbow Osteochondritis Dissecans: Alternative Source of Autologous Chondrocyte Implantation. (27956231)
2016
19
Research in Osteochondritis Dissecans of the Knee: 2016 Update. (27532280)
2016
20
Autologous osteochondral mosaicplasty in osteochondritis dissecans of the patella in adolescents. (27118373)
2016
21
Outcomes following impaction bone grafting for treatment of unstable osteochondritis dissecans. (26947463)
2016
22
From loose body to osteochondritis dissecans: a historical account of disease definition. (27900309)
2016
23
Insights into the Epiphyseal Cartilage Origin and Subsequent Osseous Manifestation of Juvenile Osteochondritis Dissecans with a Modified Clinical MR Imaging Protocol: A Pilot Study. (27631413)
2016
24
CORR Insights(Ar): Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? (27687489)
2016
25
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. (27283998)
2016
26
Tissue Bioengineering in the Treatment of Osteochondritis Dissecans of the Talus in Children With Open Physis: Preliminary Results. (27379780)
2016
27
AAOS Appropriate Use Criteria: Management of Osteochondritis Dissecans of the Femoral Condyle. (27479836)
2016
28
Management of Osteochondritis Dissecans of the Femoral Condyle. (27479835)
2016
29
7. Usefulness of Low-Intensity Pulsed Ultrasound (LIPUS) for the Treatment of Osteochondritis Dissecans (OCD) of the Humeral Capitellum. (27441768)
2016
30
Analysis of risk factors for poor prognosis in conservatively managed juvenile osteochondritis dissecans of the lateral femoral condyle. (27839659)
2016
31
Osteochondral alteration in a child treated with levetiracetam: a rare case of juvenile osteochondritis dissecans of the talar head. (27341121)
2016
32
Prevalence of Capitellar Osteochondritis Dissecans in Children With Chronic Radial Head Subluxation and Dislocation. (27010446)
2016
33
Erratum: Research in Osteochondritis Dissecans of the Knee: 2016 Update. (27776368)
2016
34
Pediatric Knee Osteochondritis Dissecans Lesions. (27637663)
2016
35
Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete. (27198896)
2016
36
Progression of stable juvenile osteochondritis dissecans after 10 years of meniscectomy of the discoid lateral meniscus. (27028045)
2016
37
Current Concepts in Treatment of Patellofemoral Osteochondritis Dissecans. (27904793)
2016
38
Sporadically occurred bilateral osteochondritis dissecans on the trochlea of the femur: case report. (27782935)
2016
39
Osteochondral Allograft Transplantation in Patients With Osteochondritis Dissecans of the Knee. (27496906)
2016
40
Osteochondritis dissecans of the fourth proximal interphalangeal joint in a Japanese drummer. (27990458)
2016
41
The Incidence of Surgery in Osteochondritis Dissecans in Children and Adolescents. (27047984)
2016
42
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly. (27388238)
2016
43
Treatment of Osteochondritis Dissecans of the Talus in Skeletally Immature Population: A Critical Analysis of the Available Evidence. (27044597)
2016
44
Arthroscopic Bioabsorbable Screw Fixation of Unstable Osteochondritis Dissecans in Adolescents: Clinical Results, Magnetic Resonance Imaging, and Second-Look Arthroscopic Findings. (26929800)
2016
45
Reliability of predictive models for non-operative healing potential of stable juvenile osteochondritis dissecans knee lesions. (27117169)
2016
46
Internal Fixation of Unstable Osteochondritis Dissecans in the Skeletally Mature Knee with Metal Screws. (27047638)
2016
47
Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. (27018370)
2016
48
The Incidence of Osteochondritis Dissecans in Adolescents Complaining of Chronic Anterior Knee Pain: 3559 June 4, 10: 30 AM - 10: 45 AM. (27361926)
2016
49
Magnetic Resonance Imaging of Osteochondritis Dissecans: Validation Study for the ICRS Classification System. (26976624)
2016
50
Results of Bone Peg Grafting for Capitellar Osteochondritis Dissecans in Adolescent Baseball Players. (27514737)
2016

Variations for Osteochondritis Dissecans

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Clinvar genetic disease variations for Osteochondritis Dissecans:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ACANNM_ 013227.3(ACAN): c.7249G> A (p.Val2417Met)SNVPathogenicrs267606625GRCh37Chr 15, 89416172: 89416172

Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.8COL9A1, COL9A3
29.8ACAN, COMP
39.5COL9A1, COL9A2, COL9A3
49.2ACAN, BMP7, MMP13
5
Show member pathways
9.1COL9A1, COL9A2, COL9A3, MMP13
6
Show member pathways
9.0BMP7, FBLN1, FBLN2
7
Show member pathways
8.8ACAN, COL9A1, COL9A2, COL9A3, MMP13
8
Show member pathways
8.7ACAN, BMP7, COL9A1, COL9A2, COL9A3
98.7ACAN, FBLN1, FBLN2, TNR
10
Show member pathways
8.6COL9A1, COL9A2, COL9A3, COMP, TNR
11
Show member pathways
8.6COL9A1, COL9A2, COL9A3, COMP, TNR
128.6COL9A1, COL9A2, COL9A3, COMP, TNR
137.5ACAN, COL9A1, COL9A2, COL9A3, COMP, MATN3
14
Show member pathways
5.5ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen type IX trimerGO:000559410.3COL9A1, COL9A2, COL9A3
2collagen trimerGO:00055819.8COL9A1, COL9A2, COL9A3, MMP13
3endoplasmic reticulum lumenGO:00057889.5COL9A1, COL9A2, COL9A3, MATN3
4extracellular matrixGO:00310128.6ACAN, BMP7, COMP, FBLN1, FBLN2, MMP13
5extracellular spaceGO:00056158.4ACAN, BMP7, COMP, FBLN1, FBLN2, MMP13
6extracellular regionGO:00055766.2ACAN, BMP7, COL9A1, COL9A2, COL9A3, COMP
7proteinaceous extracellular matrixGO:00055786.0ACAN, COL9A1, COL9A2, COL9A3, COMP, FBLN1

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth plate cartilage developmentGO:000341710.2COMP, MMP13
2animal organ morphogenesisGO:00098879.8BMP7, COL9A1, COMP
3skeletal system developmentGO:00015018.1ACAN, BMP7, COL9A2, COMP, MATN3
4extracellular matrix organizationGO:00301987.4ACAN, COL9A1, COL9A2, COL9A3, COMP, FBLN1

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:000551810.1COMP, MMP13
2extracellular matrix structural constituent conferring tensile strengthGO:00300209.5COL9A1, COL9A2, COL9A3
3extracellular matrix structural constituentGO:00052018.1ACAN, COMP, FBLN1, FBLN2, MATN3
4calcium ion bindingGO:00055098.1ACAN, COMP, FBLN1, FBLN2, MATN3, MMP13

Sources for Osteochondritis Dissecans

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet