MCID: OST009
MIFTS: 53

Osteochondritis Dissecans malady

Categories: Genetic diseases, Rare diseases, Bone diseases

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
65UMLS, 32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 24GTR, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 32 10 45 12 51 36 24 65
Osteochondritis 36 65
König Disease 45 51
 
Obsessive-Compulsive Disorder 65
Kônig Disease 45
Ocd 10

Characteristics:

Orphanet epidemiological data:

51
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:84
ICD1027 M93.2, M93.9
ICD9CM29 732.7
Orphanet51 2764
ICD10 via Orphanet28 M93.2
MESH via Orphanet37 D010008
UMLS via Orphanet66 C0029421
UMLS65 C0029420, C0029421

Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:45 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary: Osteochondritis Dissecans, also known as osteochondritis, is related to osteochondrosis and familial osteochondritis dissecans. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways are Gastric cancer network 2 and Protein digestion and absorption. The drugs citalopram and citalopram hydrobromide have been mentioned in the context of this disorder. Affiliated tissues include epiphysis, bone and brain, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:10 An ischemic bone disease that results in necrosis located in epiphysis.

Wikipedia:68 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1osteochondrosis25.7ACAN, BMP7, COL9A1, COL9A2, COL9A3, FBLN1
2familial osteochondritis dissecans12.7
3osteochondritis dissecans, short stature, and early-onset osteoarthritis12.5
4idiopathic avascular necrosis11.2
5obsessive-compulsive disorder11.0
6legg-calve-perthes disease10.3
7periostitis10.3
8osteoarthritis10.2
9osteonecrosis10.2
10stickler syndrome10.2
11multiple epiphyseal dysplasia10.2
12kohler's disease10.2
13osgood-schlatter's disease10.2
14kienbock's disease10.2
15thiemann disease, familial form10.2
16panner disease10.2
17malignant giant cell tumor of the tendon sheath10.1ACAN, MMP13
18intervertebral disc disease10.1COL9A2, COL9A3
19exercise-induced hyperinsulinism10.1COL9A1, COL9A2, COL9A3
20gingival fibromatosis10.1ACAN, COL9A1, COL9A2
21hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome10.1COL9A1, COL9A2, COL9A3
22wilson disease10.1
23spondyloepiphyseal dysplasia tarda10.1
24rickets10.1
25myopathy10.1
26dwarfism10.1
27dengue disease9.9ACAN, COL9A3, MMP13
28bone resorption disease9.9ACAN, COL9A3, MMP13
29acromesomelic dysplasia9.9COL9A1, COL9A2, COL9A3
30glycoproteinosis9.8ACAN, MMP13
31spondyloepimetaphyseal dysplasia9.7ACAN, MATN3, MMP13
32ischemic bone disease9.7ACAN, COL9A2, COL9A3, MMP13
33bone deterioration disease9.7COL9A2, COL9A3, MATN3
34multiple pterygium syndrome, dominant9.6COL9A1, COL9A2, COL9A3, MATN3
35osteochondritis dissecans9.4ACAN, COL9A1, MATN3, MMP13
36epiphyseal dysplasia, multiple, 19.3ACAN, COL9A1, COL9A2, COL9A3, MATN3
37respiratory syncytial virus infectious disease9.3ACAN, COL9A1, COL9A2, COL9A3, MATN3
38splenic marginal zone lymphoma9.3ACAN, BMP7, COL9A1, COL9A2, COL9A3
39familial partial lipodystrophy due to akt2 mutations9.2ACAN, FBLN1, FBLN2, TNR

Comorbidity relations with Osteochondritis Dissecans via Phenotypic Disease Network (PDN):


Anxiety DisorderGeneralized Anxiety Disorder
HypothyroidismMajor Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment
Dependent Personality DisorderDysthymic Disorder
Obsessive-Compulsive Personality DisorderSchizophreniform Disorder

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Drugs & Therapeutics for Osteochondritis Dissecans

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Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Fibrin Tissue AdhesivePhase 3138
2MitogensPhase 31386
3AstragalusNutraceuticalPhase 348

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1Evaluation of the Agili-C Biphasic Implant in the Knee JointActive, not recruitingNCT01471236Phase 4
2Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)WithdrawnNCT01283737Phase 4
3Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional MicrofractureRecruitingNCT01498029Phase 3
4"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral LesionsRecruitingNCT02005861Phase 3
5ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the KneeActive, not recruitingNCT01458782Phase 2, Phase 3
6Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage DefectsRecruitingNCT01694823Phase 1, Phase 2
7Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
8Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
9Osteochondritis Dissecans of Knee Prospective CohortRecruitingNCT02771496
10Repair of Articular Osteochondral DefectRecruitingNCT01409447
11DeNovo NT Longitudinal Data Collection (LDC) Knee StudyRecruitingNCT01329445
12Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the KneeRecruitingNCT01159899Phase 0
13Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionRecruitingNCT02289976
14DeNovo NT Ankle LDC StudyActive, not recruitingNCT01347892
15Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadActive, not recruitingNCT00813267Phase 0
16Osteochondritis Dissecans of the KneeEnrolling by invitationNCT01455987
17Conjoint Analysis of Patient Preferences in Joint InterventionsNot yet recruitingNCT02664337
18Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the AnkleNot yet recruitingNCT01405664
19Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage RegenerationTerminatedNCT00881023
20Chondrofix Osteochondral Allograft Prospective StudyTerminatedNCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS65/NDF-RT43:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455


Cochrane evidence based reviews: osteochondritis dissecans

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

33
Bone, Brain, Breast, Liver, Bone marrow, Endothelial, Heart

FMA organs/tissues related to Osteochondritis Dissecans:

16
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.0BMP7, COL9A1, COL9A2, FBLN1
2MP:00053717.5BMP7, COL9A1, COL9A2, FBLN1, MATN3, MMP13
3MP:00053907.4BMP7, COL9A1, COL9A2, FBLN1, MATN3, MMP13

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
A suspected genetic form of bilateral osteochondritis dissecans of the knee in a Dutch family. (26122666)
2015
2
Treatment algorithm for osteochondritis dissecans of the knee. (25435043)
2015
3
Candidate Loci are Revealed by an Initial Genome-wide Association Study of Juvenile Osteochondritis Dissecans. (26422391)
2015
4
Osteochondritis dissecans of the knee. (25606539)
2014
5
Bilateral Wrisberg discoid menisci mimicking bucket handle tears associated with osteochondritis dissecans: case report. (25171571)
2014
6
Radiographic diagnosis of osteochondritis dissecans of the temporomandibular joint: two cases. (25012532)
2014
7
State of the art: Elbow arthroscopy: review of the literature and application for osteochondritis dissecans of the capitellum. (25264040)
2014
8
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
9
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
10
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
11
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
12
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
13
Bioabsorbable fixation of unstable osteochondritis dissecans lesions. (20595548)
2010
14
Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy. (20358595)
2010
15
Case report: Fresh-stored osteochondral allograft for treatment of osteochondritis dissecans the femoral head. (19727986)
2010
16
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
17
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
18
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
19
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
20
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
21
The healing potential of stable juvenile osteochondritis dissecans knee lesions. (19047711)
2008
22
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
23
Intraoperative acoustic evaluation of living human cartilage of the elbow and knee during mosaicplasty for osteochondritis dissecans of the elbow: an in vivo study. (18796577)
2008
24
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
25
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
26
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
27
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
28
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
29
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
30
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
31
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
32
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
33
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
34
Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. (11536094)
2001
35
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
36
Osteochondral grafting and arthroplasty for end-stage osteochondritis dissecans of the capitellum. A case report and review of the literature. (11573926)
2001
37
Closed-Wedge osteotomy for osteochondritis dissecans of the capitellum. A 7- to 12-year follow-up. (10921645)
2000
38
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
39
Osteochondritis dissecans in a young pitcher: why early recognition matters. (20086894)
1997
40
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
41
Osteochondritis dissecans of the anterior tibial spine. (8305108)
1993
42
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
43
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
44
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
45
Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography. (2605451)
1989
46
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
47
Familial osteochondritis dissecans of the knee. (477064)
1979
48
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
49
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960
50

Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.8COL9A1, COL9A3
29.4COL9A1, COL9A2, COL9A3
39.4COL9A1, COL9A2, COL9A3
49.1ACAN, BMP7, MMP13
59.0COL9A1, COL9A2, COL9A3, TNR
6
Show member pathways
9.0COL9A1, COL9A2, COL9A3, TNR
7
Show member pathways
9.0COL9A1, COL9A2, COL9A3, TNR
8
Show member pathways
9.0COL9A1, COL9A2, COL9A3, MMP13
9
Show member pathways
8.7ACAN, COL9A1, COL9A2, COL9A3, MMP13
10
Show member pathways
8.5ACAN, BMP7, COL9A1, COL9A2, COL9A3
11
Show member pathways
8.5BMP7, FBLN1, FBLN2
128.4ACAN, FBLN1, FBLN2, TNR
138.2ACAN, COL9A1, COL9A2, COL9A3, MATN3, TNR
14
Show member pathways
5.8ACAN, BMP7, COL9A1, COL9A2, COL9A3, FBLN1

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.6MMP13, TNR
2collagen type IX trimerGO:00055949.1COL9A1, COL9A2, COL9A3

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:00015019.7BMP7, COL9A2
2collagen catabolic processGO:00305749.2COL9A1, COL9A3, MMP13
3extracellular matrix disassemblyGO:00226178.7ACAN, COL9A1, COL9A2, COL9A3, MMP13

Sources for Osteochondritis Dissecans

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet