OD
MCID: OST009
MIFTS: 62

Osteochondritis Dissecans (OD) malady

Bone diseases category

Summaries for Osteochondritis Dissecans

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. the loose piece may stay in place or fall into the joint space, making the joint unstable. this causes pain and feelings that the joint "sticks" or is "giving way." osteochondritis dissecans usually affects the knees and elbows. last updated: 6/4/2009

MalaCards: Osteochondritis Dissecans, also known as aseptic necrosis, is related to multiple sclerosis and stickler syndrome. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Degradation of collagen and Protein digestion and absorption. The drugs citalopram and clomipramine and the compounds polyglycolic acid and 1-Methyloxy-4-Sulfone-Benzene have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:3 Deaths from drug overdose have been rising steadily over the past two decades and have become the leading cause of injury death in the United States.1  Every day in the United States, 105 people die as a result of drug overdose, and another 6,748 are treated in emergency departments (ED) for the misuse or abuse of drugs.2 Nearly 9 out of 10 poisoning deaths are caused by drugs.3

Wikipedia:63 Osteochondritis dissecans /ˌɒsti.oʊkɒnˈdraɪtɪs ˈdɪsɨkænz/, often abbreviated to OCD or OD, is... more...

Description from OMIM:46 165800

Aliases & Classifications for Osteochondritis Dissecans

About this section
Sources:
60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 30LifeMap Discovery™, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondritis dissecans 8 42 10 30 60
aseptic necrosis 42 60
obsessive-compulsive disorder 60
ocd 8
od 42


External Ids:

Disease Ontology8 DOID:84
NCIt39 C34877
OMIM46 165800
MeSH34 D010007
ICD1025 M93.2

Related Diseases for Osteochondritis Dissecans

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.6TNR
2stickler syndrome30.5COL9A1, COL9A2
3multiple epiphyseal dysplasia30.5COL9A1, COL9A2, COL9A3, MATN3, ACAN
4osteosarcoma30.5BMP7, CD36, MMP13, NOTCH1
5osteoarthritis30.5COL9A1, COL9A2, COL9A3, BMP7, MATN3, CD36
6astrocytoma30.2MMP3, GAPDH
7arthritis30.0ACAN, MMP3
8body dysmorphic disorder10.9
9familial osteochondritis dissecans10.8
10schizophrenia10.8
11generalized anxiety disorder10.7
12major depressive disorder10.7
13hypochondriasis10.7
14obsessive-compulsive disorder10.7
15social phobia10.7
16bipolar disorder10.7
17anorexia nervosa10.6
18eating disorder10.6
19osteochondrosis10.6
20schizotypal personality disorder10.6
21dissociative disorder10.6
22mood disorder10.6
23sexual disorder10.6
24attention deficit hyperactivity disorder10.5
25alexithymia10.5
26cerebritis10.5
27neuroacanthocytosis10.5
28osteochondrodysplasia10.5
29osteonecrosis10.4
30legg-calve-perthes disease10.4
31periostitis10.4
32asperger syndrome10.4
33schizoaffective disorder10.4
34scurvy10.3
35autistic disorder10.3
36bulimia nervosa10.3
37somatization disorder10.3
38adjustment disorder10.3
39seasonal affective disorder10.3
40pain disorder10.3
41alcohol dependence10.3
42autism spectrum disorder10.3
43impulse control disorder10.3
44psychotic disorder10.3
45charge syndrome10.3
46myoclonus-dystonia10.3
47carpal tunnel syndrome10.2
48rickets10.2
49wilson disease10.2
50osgood-schlatter's disease10.2

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Clinical Features for Osteochondritis Dissecans

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

165800

Drugs & Therapeutics for Osteochondritis Dissecans

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteochondritis Dissecans

Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Search CenterWatch for Osteochondritis Dissecans

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

About this section

Anatomical Context for Osteochondritis Dissecans

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteochondritis Dissecans:

32
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

14
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Osteochondritis Dissecans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5COL9A1, BMP7, FBLN1, MATN3, MMP13, ACAN
2MP:00053778.3COL9A1, BMP7, FBLN1, NOTCH1, ACAN
3MP:00053787.3GAPDH, FBLN1, MATN3, CD36, MMP13, NOTCH1
4MP:00053907.2ACAN, COL9A1, BMP7, FBLN1, MATN3, CD36
5MP:00053857.2BMP7, GAPDH, FBLN2, FBLN1, CD36, MMP13
6MP:00053877.1COL9A1, BMP7, FBLN1, MATN3, CD36, MMP3

Publications for Osteochondritis Dissecans

About this section
Sources:
50PubMed
See all sources

Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
2
Indications for Surgical Management of Osteochondritis Dissecans of the Knee in the Pediatric Population: A Systematic Review. (24234552)
2013
3
Can fresh osteochondral allografts restore function in juveniles with osteochondritis dissecans of the knee? (22972653)
2013
4
Surgical management of osteochondritis dissecans of the knee in the paediatric population: a systematic review addressing surgical techniques. (23680989)
2013
5
Surgical treatment of osteochondritis dissecans of the talus: a systematic review. (22622794)
2012
6
Arthroscopically assisted retrograde drilling for osteochondritis dissecans (OCD) lesions of the knee. (22258653)
2012
7
A retrospective evaluation of magnetic resonance imaging effectiveness on capitellar osteochondritis dissecans among overhead athletes. (22174341)
2012
8
A genome-wide association study of osteochondritis dissecans in the Thoroughbred. (22052004)
2012
9
"One step" treatment of juvenile osteochondritis dissecans in the knee: clinical results and T2 mapping characterization. (22480472)
2012
10
The reliability to determine "healing" in osteochondritis dissecans from radiographic assessment. (22892633)
2012
11
Functional and radiographic outcomes of juvenile osteochondritis dissecans of the knee treated with extra-articular retrograde drilling. (21828362)
2011
12
Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. (20594080)
2010
13
Osteochondral autologous transplantation was more effective than microfracture for osteochondritis dissecans in children younger than eighteen years. (20720145)
2010
14
Clinical benefit of SPECT/CT for follow-up of surgical treatment of osteochondritis dissecans. (20544322)
2010
15
Midterm results of surgical treatment for adult osteochondritis dissecans of the knee. (19861695)
2009
16
Bilateral osteochondritis dissecans of the knees in monozygotic twins: the genetic factor and review of the etiology. (19911106)
2009
17
Autologous osteochondral mosaicplasty for osteochondritis dissecans of the elbow in teenage athletes. (19797570)
2009
18
Treatment of osteochondritis dissecans of the ankle with hyaluronic acid injections: a prospective study. (19138479)
2008
19
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
20
Internal fixation of unstable Cahill Type-2C osteochondritis dissecans lesions of the knee in adolescent patients. (17598495)
2007
21
Dual direct lateral portals for treatment of osteochondritis dissecans of the capitellum: an anatomic study. (17637407)
2007
22
Results of arthroscopic fixation of osteochondritis dissecans lesion of the knee with cylindrical autogenous osteochondral plugs. (17192319)
2007
23
Comparison of subchondral lesion size between clinical and non-clinical medial trochlear ridge talar osteochondritis dissecans in dogs. (17364089)
2007
24
Autologous osteochondral mosaicplasty for capitellar osteochondritis dissecans in teenaged patients. (16567456)
2006
25
Osteochondritis dissecans of the humeral head: clinical and radiological findings. (16185007)
2005
26
Internal fixation for osteochondritis dissecans of the knee. (15164164)
2005
27
Are bone bruises a possible cause of osteochondritis dissecans of the capitellum? A case report and review of the literature. (16142476)
2005
28
Bilateral stifle osteochondritis dissecans in a cat. (15634871)
2005
29
Lateral compression injuries in the pediatric elbow: Panner's disease and osteochondritis dissecans of the capitellum. (15473676)
2004
30
Surgical fixation of massive osteochondritis dissecans lesion using cylindrical osteochondral plugs. (15525932)
2004
31
Osteochondritis dissecans of the elbow. (15116649)
2004
32
Osteochondritis dissecans of the hip. (12631002)
2003
33
Osteochondral autografts for osteochondritis dissecans of the talus. (14655884)
2003
34
Osteochondritis dissecans of the humeral head in an amateur boxer. (12469092)
2002
35
The arthroscopic treatment of osteochondritis dissecans of the knee with autologous bone sticks. (12368780)
2002
36
Natural progression of osteochondritis dissecans of the humeral capitellum: initial observations. (10887249)
2000
37
Treatment of unstable osteochondritis dissecans lesions of the knee using autogenous osteochondral grafts (mosaicplasty). (10231112)
1999
38
Early detection of osteochondritis dissecans of the capitellum in young baseball players. Report of three cases. (9655108)
1998
39
Osteochondritis dissecans of the femoral condyle in the growth stage. (9577424)
1998
40
Osteochondritis dissecans of the humeral head. (9463857)
1998
41
Osteochondritis dissecans of the femoral condyle treated with periosteal transplantation. Poor outcome in 14 patients followed for 6-9 years. (9930104)
1998
42
Osteochondritis dissecans as a cause of developmental dislocation of the radial head. (9170360)
1997
43
Current treatment modalities of osteochondritis dissecans of the knee joint: results of a nation-wide German survey. (8767156)
1996
44
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
45
Computed tomographic arthrography in the assessment of osteochondritis dissecans of the elbow. (8162677)
1994
46
Osteochondritis dissecans of the lateral humeral condyle in a table tennis player. (1956260)
1991
47
Osteochondritis dissecans of the tarsocrural joint: results of treatment with arthroscopic surgery. (1884694)
1991
48
Osteochondritis dissecans of the knee: value of MR imaging in determining lesion stability and the presence of articular cartilage defects. (2117355)
1990
49
Familial osteochondritis dissecans of the knee. (477064)
1979
50
The nature of osteochondrosis in animals. Summary and conclusions with comparative aspects on osteochondritis dissecans in man. (233601)
1978

Genetic Variations for Osteochondritis Dissecans

About this section

Expression for genes affiliated with Osteochondritis Dissecans

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

About this section
Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
See all sources

Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MMP3, MMP13
29.6COL9A3, COL9A2, COL9A1
3
Hide members
9.6COL9A3, COL9A2, COL9A1
4
Cell adhesion ECM remodeling
Hide members
9.6MMP13, MMP3, ACAN
59.6BMP7, MMP13, ACAN
6
Hide members
9.3BMP7, COL9A3, COL9A2, COL9A1
7
Hide members
9.2COL9A1, COL9A2, COL9A3, CD36
8
Hide members
9.2FBLN1, FBLN2, BMP7
9
Hide members
9.0COL9A1, COL9A2, COL9A3, MMP13, MMP3
10
Hide members
8.6COL9A2, COL9A3, TNR, MATN3, CD36, ACAN
11
Hide members
8.6COL9A1, COL9A2, COL9A3, CD36, MMP13, MMP3
12
Cell adhesion Cell-matrix glycoconjugates
Hide members
8.5TNR, FBLN2, FBLN1, MMP3, ACAN
13
Hide members
6.8ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Compounds for genes affiliated with Osteochondritis Dissecans

About this section
Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4410.3BMP7, ACAN
21-Methyloxy-4-Sulfone-Benzene1110.2MMP13, MMP3
33-Methylpyridine1110.2MMP13, MMP3
4Hydroxyaminovaline1110.2MMP13, MMP3
5cyanogen bromide4410.2MMP13
6thermolysin4410.1MMP3, MMP13
7chitosan4410.0ACAN, CD36
8uk 3833675910.0MMP13, MMP3
9clodronate44 49 1112.0CD36, MMP13
10gi 254023x5910.0MMP13, MMP3
11gm 60015910.0MMP13, MMP3
12pirfenidone44 5910.9CD36, BMP7
13latanoprost44 1110.9GAPDH, MMP3
14keratan sulfate449.9ACAN, MMP3, CD36
15(4-aminophenyl)mercuric acetate449.9CD36, MMP13, MMP3
16alendronate44 49 1111.8CD36, MMP13, MMP3
17batimastat44 59 1111.8CD36, MMP13, MMP3
18hydroxyapatite449.7BMP7, CD36, MMP13
19doxycycline44 1110.7MMP13, MMP3, NOTCH1
20glucosamine44 11 2411.6ACAN, MMP3, MMP13, CD36
21procollagen449.6ACAN, MMP3, MMP13, CD36
22prednisolone44 28 1111.6MMP3, MMP13, GAPDH
23glycosaminoglycan449.6CD36, MMP13, MMP3, ACAN
24hyaluronic acid44 2410.6ACAN, MMP3, MMP13, CD36
25safranin o449.6ACAN, MMP3, CD36, BMP7
26sb 20358044 5910.5CD36, MMP13, MMP3, ACAN
27serine449.5MMP3, MMP13, BMP7
28dexamethasone44 49 28 1112.5BMP7, MMP13, NOTCH1, ACAN
29glyceraldehyde 3-phosphate449.5ACAN, MMP3, MMP13, GAPDH
30agarose449.4ACAN, MMP13, GAPDH, BMP7
31vitamin d449.4ACAN, MMP3, CD36, BMP7
32pyridinoline449.4MMP3, CD36
33neurocan449.3TNR, FBLN2, FBLN1, ACAN
34ribonucleic acid449.3MMP3, MMP13, GAPDH, BMP7
35alginate449.3BMP7, CD36, MMP13, MMP3, ACAN
36tgf beta1449.3BMP7, CD36, MMP13, MMP3, ACAN
37creatinine449.2BMP7, CD36, MMP3
38glutamine449.2COL9A2, GAPDH, CD36, MMP3
39genistein44 28 59 2 11 2414.2CD36, MMP13, MMP3, NOTCH1
40chondroitin sulfate44 2410.2TNR, CD36, MMP13, MMP3, ACAN
41cycloheximide448.9BMP7, GAPDH, CD36, MMP13, MMP3
42ascorbic acid44 249.8BMP7, GAPDH, CD36, MMP13, MMP3, ACAN
43pge2448.7BMP7, GAPDH, CD36, MMP13, MMP3, ACAN
44matrigel448.7FBLN1, CD36, MMP13, MMP3, NOTCH1
45oxygen44 249.5BMP7, GAPDH, MMP13, MMP3, NOTCH1
46vegf448.4BMP7, GAPDH, CD36, MMP13, MMP3, NOTCH1
47retinoic acid44 249.2BMP7, GAPDH, CD36, MMP13, MMP3, NOTCH1
48heparin44 28 11 2411.1BMP7, GAPDH, FBLN2, FBLN1, CD36, MMP13
49estrogen447.8BMP7, GAPDH, FBLN1, CD36, MMP13, MMP3
50calcium44 49 11 2410.3TNR, BMP7, FBLN2, FBLN1, MATN3, CD36

GO Terms for genes affiliated with Osteochondritis Dissecans

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6COL9A3, COL9A2, COL9A1
2collagen type IXGO:0055949.5COL9A3, COL9A2, COL9A1
3extracellular matrixGO:0310129.0FBLN2, FBLN1, ACAN
4proteinaceous extracellular matrixGO:0055788.0TNR, FBLN2, FBLN1, MATN3, MMP13, MMP3
5extracellular regionGO:0055766.3ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:20001219.6CD36, BMP7
2branching morphogenesis of an epithelial tubeGO:0487549.6NOTCH1, BMP7
3skeletal system developmentGO:0015019.4COL9A2, BMP7, MATN3, ACAN
4negative regulation of neurogenesisGO:0507689.3NOTCH1, BMP7
5collagen catabolic processGO:0305749.2COL9A1, COL9A2, COL9A3, MMP13, MMP3
6extracellular matrix disassemblyGO:0226179.1COL9A1, COL9A2, COL9A3, MMP13, MMP3
7axon guidanceGO:0074118.9BMP7, TNR, COL9A3, COL9A2, COL9A1
8extracellular matrix organizationGO:0301987.0ACAN, COL9A1, COL9A2, COL9A3, TNR, BMP7

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.5COL9A3, COL9A2, COL9A1
2extracellular matrix structural constituentGO:0052018.8FBLN2, FBLN1, MATN3, ACAN
3calcium ion bindingGO:0055098.4NOTCH1, MMP3, MMP13, FBLN1, FBLN2

Products for genes affiliated with Osteochondritis Dissecans

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondritis Dissecans

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet