MCID: OST009
MIFTS: 66

Osteochondritis Dissecans malady

Genetic diseases, Rare diseases, Bone diseases categories

Summaries for Osteochondritis Dissecans

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NIH Rare Diseases:43 Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary: Osteochondritis Dissecans, also known as aseptic necrosis, is related to stickler syndrome and multiple epiphyseal dysplasia. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Gastric cancer network 2 and Elastic fibre formation. The drugs citalopram and clomipramine and the compounds neurocan and chitosan have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:10 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:4 This content has moved to our new web site, www.cdc.gov/DrugOverdose. You will be automatically redirected there now.

Wikipedia:65 Osteochondritis dissecans /??sti.o?k?n?dra?t?s ?d?s?k more...

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
32LifeMap Discovery®, 10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 49Orphanet, 4CDC, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Osteochondritis Dissecans, Aliases & Descriptions:

Name: Osteochondritis Dissecans 32 10 43 12 49 62
Aseptic Necrosis 43 62
Kônig Disease 43 49
 
Od 43 4
Obsessive-Compulsive Disorder 62
Ocd 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases
Orphanet: 49 
Rare bone diseases


Characteristics (Orphanet epidemiological data):

49
osteochondritis dissecans:
Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:84
MeSH35 D010007
NCIt40 C34877
Orphanet49 2764
MESH via Orphanet36 D010008
ICD10 via Orphanet28 M93.2
UMLS via Orphanet63 C0029421
ICD1027 M93.2

Related Diseases for Osteochondritis Dissecans

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Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1stickler syndrome30.7COL9A1, COL9A2
2multiple epiphyseal dysplasia30.6MATN3, COL9A1, COL9A3, COL9A2, ACAN
3osteoarthritis30.4MMP13, MMP3, CD36, NOTCH1, MATN3, COL9A1
4arthritis30.1ACAN, MMP3
5familial osteochondritis dissecans11.0
6obsessive-compulsive disorder10.8
7osteochondrosis10.7
8osteochondritis dissecans, short stature, and early-onset osteoarthritis10.6
9osteochondrodysplasia10.5
10legg-calve-perthes disease10.5
11periostitis10.5
12osteonecrosis10.4
13pandas10.4
14wilson disease10.3
15rickets10.3
16osgood-schlatter's disease10.3
17myopathy10.3
18dwarfism10.3
19kienbock's disease10.3
20osteoarthropathy of fingers familial10.3
21osteochondritis of tarsal/metatarsal bone10.3
22panner disease10.3
23gaucher disease, type i10.2
24thalassemia10.2
25gaucher's disease10.2
26cushing's syndrome10.2
27trichotillomania10.1
28gilles de la tourette syndrome10.1
29panic disorder10.1
30agoraphobia10.1
31pathological gambling10.1
32anxiety disorder10.1
33gaucher disease, type iii10.1
34metachondromatosis10.1
35osteopetrosis, autosomal dominant 210.1
36mucopolysaccharidosis is10.1
37dyskeratosis congenita, autosomal recessive 410.1
38osteopetrosis, autosomal recessive 3, with renal tubular acidosis10.1
39exostoses, multiple, type 110.1
40dysautonomia, familial10.1
41mannosidosis, alpha-, types i and ii10.1
42behcet's disease10.1
43crohn's disease10.1
44dyskeratosis congenita10.1
45lymphangitis10.1
46myxedema10.1
47erdheim-chester disease10.1
48mixed connective tissue disease10.1
49dysbaric osteonecrosis10.1
50primary hypertrophic osteoarthropathy10.1

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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Drugs & Therapeutics for Osteochondritis Dissecans

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Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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MalaCards organs/tissues related to Osteochondritis Dissecans:

33
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

16
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6FBLN1, MMP13, ACAN, BMP7, COL9A1, MATN3
2MP:00053778.4FBLN1, ACAN, BMP7, COL9A1, NOTCH1
3MP:00053677.7FBLN1, BMP7, GAPDH, NOTCH1, CD36
4MP:00053857.1FBLN1, FBLN2, MMP13, ACAN, BMP7, GAPDH
5MP:00053877.0FBLN1, MMP3, ACAN, BMP7, COL9A1, MATN3
6MP:00053767.0MMP3, ACAN, COL9A1, GAPDH, NOTCH1, CD36
7MP:00036317.0FBLN1, TNR, MMP3, ACAN, BMP7, NOTCH1
8MP:00053786.8FBLN1, MMP13, ACAN, BMP7, MATN3, GAPDH
9MP:00053906.7CD36, FBLN1, MMP13, MMP3, ACAN, BMP7

Publications for Osteochondritis Dissecans

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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Treatment algorithm for osteochondritis dissecans of the knee. (25435043)
2015
2
Osteochondritis dissecans of the knee. (25606539)
2014
3
Bilateral Wrisberg discoid menisci mimicking bucket handle tears associated with osteochondritis dissecans: case report. (25171571)
2014
4
Radiographic diagnosis of osteochondritis dissecans of the temporomandibular joint: two cases. (25012532)
2014
5
State of the art: Elbow arthroscopy: review of the literature and application for osteochondritis dissecans of the capitellum. (25264040)
2014
6
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
7
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
8
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
9
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
10
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
11
Bioabsorbable fixation of unstable osteochondritis dissecans lesions. (20595548)
2010
12
Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy. (20358595)
2010
13
Case report: Fresh-stored osteochondral allograft for treatment of osteochondritis dissecans the femoral head. (19727986)
2010
14
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
15
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
16
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
17
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
18
Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. (20594080)
2010
19
Midterm results of surgical treatment for adult osteochondritis dissecans of the knee. (19861695)
2009
20
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
21
The healing potential of stable juvenile osteochondritis dissecans knee lesions. (19047711)
2008
22
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
23
Intraoperative acoustic evaluation of living human cartilage of the elbow and knee during mosaicplasty for osteochondritis dissecans of the elbow: an in vivo study. (18796577)
2008
24
Osteochondritis dissecans of the tarsal navicular. (18442463)
2008
25
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
26
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
27
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
28
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
29
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
30
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
31
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
32
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
33
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
34
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
35
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
36
Closed-Wedge osteotomy for osteochondritis dissecans of the capitellum. A 7- to 12-year follow-up. (10921645)
2000
37
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
38
Osteochondritis dissecans in a young pitcher: why early recognition matters. (20086894)
1997
39
Osteochondritis dissecans of the distal femur and patella. (9012566)
1997
40
Osteochondritis dissecans of the knee. (20086997)
1996
41
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
42
Osteochondritis dissecans of the anterior tibial spine. (8305108)
1993
43
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
44
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
45
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
46
Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography. (2605451)
1989
47
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
48
Familial osteochondritis dissecans of the knee. (477064)
1979
49
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
50
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960

Variations for Osteochondritis Dissecans

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Expression for genes affiliated with Osteochondritis Dissecans

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Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8COL9A1, COL9A3
2
Show member pathways
9.5BMP7, FBLN2, FBLN1
39.4COL9A2, COL9A3, COL9A1
49.4COL9A1, COL9A3, COL9A2
5
Show member pathways
9.4COL9A2, COL9A3, COL9A1
69.4MMP13, ACAN, BMP7
7
Show member pathways
9.3MMP13, MMP3, ACAN
8
Show member pathways
9.0COL9A1, COL9A3, COL9A2, BMP7
98.9FBLN1, FBLN2, TNR, MMP3, ACAN
108.6TNR, ACAN, COL9A2, COL9A3, COL9A1, MATN3
11
Show member pathways
8.5MMP13, MMP3, COL9A2, COL9A3, COL9A1
12
Show member pathways
8.3NOTCH1, BMP7, MMP3, MMP13
13
Show member pathways
8.2BMP7, COL9A2, COL9A3, COL9A1, NOTCH1
14
Show member pathways
8.0COL9A2, COL9A3, COL9A1, NOTCH1, CD36
15
Show member pathways
7.9MMP13, MMP3, COL9A2, COL9A3, COL9A1, CD36
16
Show member pathways
6.7MATN3, FBLN1, FBLN2, TNR, MMP13, MMP3

Compounds for genes affiliated with Osteochondritis Dissecans

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Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1neurocan459.9ACAN, TNR, FBLN2, FBLN1
2chitosan459.8ACAN, CD36
3thermolysin459.8MMP13, MMP3
4latanoprost45 1310.8MMP3, GAPDH
5uk 383367619.7MMP13, MMP3
6clodronate45 51 1311.7CD36, MMP13
7gi 254023x619.7MMP13, MMP3
8pirfenidone45 6110.6CD36, BMP7
9gm 6001619.6MMP13, MMP3
10polyglycolic acid459.6ACAN, BMP7, CD36
11sulfonamide459.5MMP3, MMP13
12keratan sulfate459.5CD36, ACAN, MMP3
13cyanogen bromide459.4CD36, MMP13
14(4-aminophenyl)mercuric acetate459.3CD36, MMP3, MMP13
15hydroxyapatite459.3CD36, BMP7, MMP13
16prednisolone45 30 1311.3MMP13, MMP3, GAPDH
17alendronate45 51 1311.3MMP13, MMP3, CD36
18batimastat45 61 1311.3MMP13, MMP3, CD36
19agarose459.2MMP13, ACAN, BMP7, GAPDH
20glyceraldehyde 3-phosphate459.2GAPDH, ACAN, MMP3, MMP13
21glucosamine45 26 1311.1MMP13, MMP3, ACAN, CD36
22procollagen459.1MMP13, MMP3, ACAN, CD36
23glycosaminoglycan459.1CD36, ACAN, MMP3, MMP13
24safranin o459.1CD36, BMP7, ACAN, MMP3
25doxycycline45 1310.1NOTCH1, MMP3, MMP13
26hyaluronic acid45 2610.1CD36, ACAN, MMP3, MMP13
27pyridinoline459.0CD36, MMP3
28sb 20358045 6110.0MMP13, MMP3, ACAN, CD36
29nacl459.0MMP13, MMP3, BMP7
30dmso459.0CD36, GAPDH, MMP3
31vitamin d459.0MMP3, ACAN, BMP7, CD36
32ribonucleic acid458.9MMP13, MMP3, BMP7, GAPDH
33chondroitin sulfate45 269.8TNR, MMP13, MMP3, ACAN, CD36
34glutamine458.8CD36, GAPDH, COL9A2, MMP3
35alginate458.7MMP13, MMP3, ACAN, BMP7, CD36
36tgf beta1458.7MMP13, MMP3, ACAN, BMP7, CD36
37creatinine458.6CD36, GAPDH, BMP7, MMP3
38genistein45 30 61 3 26 1313.4CD36, NOTCH1, MMP3, MMP13
39cycloheximide458.3MMP13, MMP3, BMP7, GAPDH, CD36
40matrigel458.3FBLN1, MMP13, MMP3, NOTCH1, CD36
41ascorbic acid45 269.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
42pge2458.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
43oxygen45 269.0MMP13, MMP3, BMP7, GAPDH, NOTCH1
44heparin45 30 26 1310.9FBLN1, FBLN2, MMP13, MMP3, BMP7, GAPDH
45dexamethasone45 51 30 1310.8MMP13, MMP3, ACAN, BMP7, NOTCH1, CD36
46vegf457.5MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
47serine457.4MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
48retinoic acid45 268.3MMP13, MMP3, ACAN, BMP7, GAPDH, NOTCH1
49estrogen457.3FBLN1, MMP13, MMP3, BMP7, GAPDH, NOTCH1
50calcium45 51 26 1310.0FBLN1, FBLN2, TNR, MMP13, MMP3, BMP7

GO Terms for genes affiliated with Osteochondritis Dissecans

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Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.4COL9A1, COL9A3, COL9A2
2collagen type IXGO:00055949.3COL9A1, COL9A3, COL9A2
3extracellular matrixGO:00310129.0FBLN1, FBLN2, ACAN, BMP7
4proteinaceous extracellular matrixGO:00055788.2FBLN1, FBLN2, TNR, MMP13, MMP3, ACAN
5extracellular regionGO:00055765.9NOTCH1, FBLN1, FBLN2, TNR, MMP13, MMP3

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:020001219.5BMP7, CD36
2skeletal system developmentGO:00015019.3MATN3, COL9A2, BMP7, ACAN
3proteolysisGO:00065089.2MMP13, MMP3, ACAN
4negative regulation of neurogenesisGO:00507689.2NOTCH1, BMP7
5epithelial to mesenchymal transitionGO:00018379.2NOTCH1, BMP7
6branching morphogenesis of an epithelial tubeGO:00487548.9NOTCH1, BMP7
7axon guidanceGO:00074118.8TNR, BMP7, COL9A2, COL9A3, COL9A1
8collagen catabolic processGO:00305748.7MMP13, MMP3, COL9A2, COL9A3, COL9A1
9extracellular matrix disassemblyGO:00226178.5MMP13, MMP3, ACAN, COL9A2, COL9A3, COL9A1
10extracellular matrix organizationGO:00301986.9MATN3, FBLN1, FBLN2, TNR, MMP13, MMP3

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:00300209.3COL9A1, COL9A3, COL9A2
2extracellular matrix structural constituentGO:00052019.1FBLN1, FBLN2, ACAN, MATN3
3calcium ion bindingGO:00055098.2NOTCH1, MMP3, MMP13, FBLN2, FBLN1

Products for genes affiliated with Osteochondritis Dissecans

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Sources for Osteochondritis Dissecans

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet