OCD
MCID: OST009
MIFTS: 49

Osteochondritis Dissecans (OCD) malady

Categories: Rare diseases, Bone diseases, Genetic diseases

Aliases & Classifications for Osteochondritis Dissecans

Aliases & Descriptions for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 38 12 50 56 29 42 14 69
Osteochondritis 42 69
König Disease 50 56
Ocd 12 14
Kônig Disease 50

Characteristics:

Orphanet epidemiological data:

56
osteochondritis dissecans
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:84
ICD10 33 M93.2 M93.9
ICD9CM 35 732.7
Orphanet 56 ORPHA2764
ICD10 via Orphanet 34 M93.2
MESH via Orphanet 43 D010008
UMLS via Orphanet 70 C0029421

Summaries for Osteochondritis Dissecans

NIH Rare Diseases : 50 osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary : Osteochondritis Dissecans, also known as osteochondritis, is related to osteonecrosis and familial osteochondritis dissecans. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Fibrin Tissue Adhesive and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include bone and epiphysis, and related phenotypes are limbs/digits/tail and hearing/vestibular/ear

Disease Ontology : 12 An ischemic bone disease that results_in necrosis located in epiphysis.

Wikipedia : 71 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

Related Diseases for Osteochondritis Dissecans

Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 osteonecrosis 29.4 ACAN COL9A1 COMP MATN3 MMP13
2 familial osteochondritis dissecans 12.7
3 osteochondritis dissecans, short stature, and early-onset osteoarthritis 12.6
4 obsessive-compulsive disorder 11.6
5 pandas 11.1
6 trichotillomania 11.1
7 gilles de la tourette syndrome 11.1
8 idiopathic avascular necrosis 11.1
9 osteochondrosis 10.4
10 legg-calve-perthes disease 10.2
11 periostitis 10.2
12 cerebral beriberi 10.1 COL9A2 COL9A3
13 cerebral palsy 10.1 ACAN COMP
14 epiphyseal dysplasia, multiple, with myopia and deafness 10.1 ACAN COMP
15 vulvar sarcoma 10.1 ACAN COMP
16 kohler's disease 10.1
17 osgood-schlatter's disease 10.1
18 kienbock's disease 10.1
19 thiemann disease 10.1
20 sp7-related osteogenesis imperfecta 10.1 ACAN COMP
21 multiple epiphyseal dysplasia 10.1
22 osteoarthritis 10.1
23 stickler syndrome 10.1
24 vitelliform macular dystrophy 10.1 COL9A2 COMP
25 albright's hereditary osteodystrophy 10.0 ACAN COMP
26 familial thoracic aortic aneurysm and dissection 10.0 ACAN FBLN1 FBLN2 TNR
27 mild hemophilia a 10.0 COL9A1 COL9A2 COL9A3
28 maternally-inherited mitochondrial dystonia 10.0 COL9A1 COL9A2 COL9A3
29 charcot-marie-tooth disease type 5 10.0 COL9A1 COL9A2 COL9A3
30 slti salem syndrome 10.0 COMP MATN3
31 dentin dysplasia 10.0 ACAN COL9A3 MMP13
32 stickler syndrome, type v 9.9 COL9A2 COL9A3
33 rickets 9.9
34 myopathy 9.9
35 wilson disease 9.9
36 dwarfism 9.9
37 spondyloepiphyseal dysplasia tarda 9.9
38 short stature, optic nerve atrophy, and pelger-huet anomaly 9.9 ACAN MATN3 MMP13
39 bone structure disease 9.9 COL9A2 COMP MATN3
40 bone angioendothelial sarcoma 9.9 ACAN COMP MMP13
41 neuropathy, distal hereditary motor, type iia 9.9 COMP MMP13
42 myopia, x-linked 9.6 COL9A1 COL9A2 COL9A3 COMP MATN3
43 syngnathia cleft palate 9.6 ACAN BMP7 COL9A1 COL9A2 COL9A3
44 bone resorption disease 9.5 ACAN BMP7 COL9A2 COL9A3 MMP13
45 physical disorder 9.5 ACAN BMP7 COL9A2 COL9A3 MMP13
46 immunodeficiency 30 9.5 ACAN COL9A1 COL9A2 COL9A3 COMP MATN3
47 intermediate uveitis 9.5 ACAN COL9A1 COL9A2 COL9A3 COMP MATN3
48 osteopetrosis 8.6 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to Osteochondritis Dissecans

Symptoms & Phenotypes for Osteochondritis Dissecans

MGI Mouse Phenotypes related to Osteochondritis Dissecans:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.5 BMP7 COL9A1 COL9A2 COMP FBLN1 MATN3
2 hearing/vestibular/ear MP:0005377 9.46 BMP7 COL9A1 COL9A2 FBLN1
3 skeleton MP:0005390 9.17 BMP7 COL9A1 COL9A2 COMP FBLN1 MATN3

Drugs & Therapeutics for Osteochondritis Dissecans

Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 3
2 Mitogens Phase 3
3 Astragalus Nutraceutical

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD) Withdrawn NCT01283737 Phase 4
2 Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture Unknown status NCT01498029 Phase 3
3 A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects. Completed NCT02993510 Phase 3
4 ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782 Phase 2, Phase 3
5 Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2
6 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
7 Repair of Articular Osteochondral Defect Unknown status NCT01409447
8 Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the Ankle Unknown status NCT01405664
9 Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head Unknown status NCT00813267 Early Phase 1
10 Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee Unknown status NCT01159899 Early Phase 1
11 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976
12 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298
13 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278
14 Osteochondritis Dissecans of Knee Prospective Cohort Recruiting NCT02771496
15 "One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions Recruiting NCT02005861
16 Conjoint Analysis of Patient Preferences in Joint Interventions Recruiting NCT02664337
17 Evaluation of the Agili-C Biphasic Implant in the Knee Joint Active, not recruiting NCT01471236
18 DeNovo NT Longitudinal Data Collection (LDC) Knee Study Active, not recruiting NCT01329445
19 DeNovo NT Ankle LDC Study Active, not recruiting NCT01347892
20 Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration Terminated NCT00881023
21 Chondrofix Osteochondral Allograft Prospective Study Terminated NCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Juvenile neocartilage (RevaFlex PMIDs: 11603712 23465950 20423988 21439468 19880363 15742595 21828366 20025455

Cochrane evidence based reviews: osteochondritis dissecans

Genetic Tests for Osteochondritis Dissecans

Genetic tests related to Osteochondritis Dissecans:

id Genetic test Affiliating Genes
1 Osteochondritis Dissecans 29

Anatomical Context for Osteochondritis Dissecans

MalaCards organs/tissues related to Osteochondritis Dissecans:

39
Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondritis Dissecans:

18
Epiphysis

Publications for Osteochondritis Dissecans

Articles related to Osteochondritis Dissecans:

(show top 50) (show all 625)
id Title Authors Year
1
Radiographic comparison of adolescent athletes with elbow osteochondritis dissecans to ulnar collateral ligament injuries and controls. ( 28087165 )
2017
2
Osteochondritis dissecans located on the medial tibial plateau: a case report. ( 28049517 )
2017
3
Osteochondritis Dissecans of the Capitellum: Diagnosis and Treatment. ( 26977547 )
2016
4
Mosaicplasty for femoral osteochondritis dissecans. ( 26896409 )
2016
5
Arthroscopic Autologous Chondrocyte Transplantation for Osteochondritis Dissecans of theA Elbow. ( 27656389 )
2016
6
Arthroscopy of the Dorsal and Plantar Pouches of the Tarsocrural Joint for the Treatment of Osteochondritis Dissecans in the Horse: Clinical Features and Follow-Up. ( 27684059 )
2016
7
Osteochondritis dissecans of the capitellum in adolescents. ( 26925381 )
2016
8
Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? ( 27600715 )
2016
9
Catcher's Knee: Posterior Femoral Condyle Juvenile Osteochondritis Dissecans in Children and Adolescents. ( 27442212 )
2016
10
Bone-peg grafting for osteochondritis dissecans of the humeral capitellum. ( 27122513 )
2016
11
The Incidence of Osteochondritis Dissecans in Adolescents Complaining of Chronic Anterior Knee Pain: 2351 Board #5. ( 27584430 )
2016
12
Fresh osteochondral allograft transplantation for osteochondritis dissecans of the capitellum in baseball players. ( 27742247 )
2016
13
Erratum to: Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? ( 27757802 )
2016
14
Novel Arthroscopic Classification of Osteochondritis Dissecans of the Knee: A Multicenter Reliability Study. ( 27159302 )
2016
15
Osteochondritis dissecans on the medial aspect of the humeral head. ( 27186062 )
2016
16
Return to Sport After Operative Management of Osteochondritis Dissecans of the Capitellum: A Systematic Review and Meta-analysis. ( 27482526 )
2016
17
Osteochondritis Dissecans of the Humeral Capitellum Associated with a Large Subchondral Bone Cyst: Two Cases Report. ( 27454643 )
2016
18
Viability of Cells From Displaced Fragments of the Elbow Osteochondritis Dissecans: Alternative Source of Autologous Chondrocyte Implantation. ( 27956231 )
2016
19
Research in Osteochondritis Dissecans of the Knee: 2016 Update. ( 27532280 )
2016
20
Autologous osteochondral mosaicplasty in osteochondritis dissecans of the patella in adolescents. ( 27118373 )
2016
21
Outcomes following impaction bone grafting for treatment of unstable osteochondritis dissecans. ( 26947463 )
2016
22
From loose body to osteochondritis dissecans: a historical account of disease definition. ( 27900309 )
2016
23
Insights into the Epiphyseal Cartilage Origin and Subsequent Osseous Manifestation of Juvenile Osteochondritis Dissecans with a Modified Clinical MR Imaging Protocol: A Pilot Study. ( 27631413 )
2016
24
CORR Insights(Ar): Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? ( 27687489 )
2016
25
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. ( 27283998 )
2016
26
Tissue Bioengineering in the Treatment of Osteochondritis Dissecans of the Talus in Children With Open Physis: Preliminary Results. ( 27379780 )
2016
27
AAOS Appropriate Use Criteria: Management of Osteochondritis Dissecans of the Femoral Condyle. ( 27479836 )
2016
28
Management of Osteochondritis Dissecans of the Femoral Condyle. ( 27479835 )
2016
29
7. Usefulness of Low-Intensity Pulsed Ultrasound (LIPUS) for the Treatment of Osteochondritis Dissecans (OCD) of the Humeral Capitellum. ( 27441768 )
2016
30
Analysis of risk factors for poor prognosis in conservatively managed juvenile osteochondritis dissecans of the lateral femoral condyle. ( 27839659 )
2016
31
Osteochondral alteration in a child treated with levetiracetam: a rare case of juvenile osteochondritis dissecans of the talar head. ( 27341121 )
2016
32
Prevalence of Capitellar Osteochondritis Dissecans in Children With Chronic Radial Head Subluxation and Dislocation. ( 27010446 )
2016
33
Erratum: Research in Osteochondritis Dissecans of the Knee: 2016 Update. ( 27776368 )
2016
34
Pediatric Knee Osteochondritis Dissecans Lesions. ( 27637663 )
2016
35
Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete. ( 27198896 )
2016
36
Progression of stable juvenile osteochondritis dissecans after 10 years of meniscectomy of the discoid lateral meniscus. ( 27028045 )
2016
37
Current Concepts in Treatment of Patellofemoral Osteochondritis Dissecans. ( 27904793 )
2016
38
Sporadically occurred bilateral osteochondritis dissecans on the trochlea of the femur: case report. ( 27782935 )
2016
39
Osteochondral Allograft Transplantation in Patients With Osteochondritis Dissecans of the Knee. ( 27496906 )
2016
40
Osteochondritis dissecans of the fourth proximal interphalangeal joint in a Japanese drummer. ( 27990458 )
2016
41
The Incidence of Surgery in Osteochondritis Dissecans in Children and Adolescents. ( 27047984 )
2016
42
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly. ( 27388238 )
2016
43
Treatment of Osteochondritis Dissecans of the Talus in Skeletally Immature Population: A Critical Analysis of the Available Evidence. ( 27044597 )
2016
44
Arthroscopic Bioabsorbable Screw Fixation of Unstable Osteochondritis Dissecans in Adolescents: Clinical Results, Magnetic Resonance Imaging, and Second-Look Arthroscopic Findings. ( 26929800 )
2016
45
Reliability of predictive models for non-operative healing potential of stable juvenile osteochondritis dissecans knee lesions. ( 27117169 )
2016
46
Internal Fixation of Unstable Osteochondritis Dissecans in the Skeletally Mature Knee with Metal Screws. ( 27047638 )
2016
47
Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. ( 27018370 )
2016
48
The Incidence of Osteochondritis Dissecans in Adolescents Complaining of Chronic Anterior Knee Pain: 3559 June 4, 10: 30 AM - 10: 45 AM. ( 27361926 )
2016
49
Magnetic Resonance Imaging of Osteochondritis Dissecans: Validation Study for the ICRS Classification System. ( 26976624 )
2016
50
Results of Bone Peg Grafting for Capitellar Osteochondritis Dissecans in Adolescent Baseball Players. ( 27514737 )
2016

Variations for Osteochondritis Dissecans

ClinVar genetic disease variations for Osteochondritis Dissecans:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ACAN NM_013227.3(ACAN): c.7249G> A (p.Val2417Met) single nucleotide variant Pathogenic rs267606625 GRCh37 Chromosome 15, 89416172: 89416172

Expression for Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for Osteochondritis Dissecans

Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 ACAN COL9A1 COL9A2 COL9A3 MMP13
2
Show member pathways
12.77 ACAN BMP7 COL9A1 COL9A2 COL9A3
3
Show member pathways
12.6 COL9A1 COL9A2 COL9A3 COMP TNR
4
Show member pathways
12.52 COL9A1 COL9A2 COL9A3 MMP13
5 12.25 COL9A1 COL9A2 COL9A3 COMP TNR
6
Show member pathways
12.02 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP
7
Show member pathways
11.83 COL9A1 COL9A2 COL9A3 COMP TNR
8
Show member pathways
11.5 BMP7 FBLN1 FBLN2
9 11.39 ACAN BMP7 MMP13
10 11.26 ACAN COL9A1 COL9A2 COL9A3 COMP MATN3
11 11.11 COL9A1 COL9A2 COL9A3
12 11.1 ACAN COMP
13 11.05 ACAN FBLN1 FBLN2 TNR
14 11.03 COL9A1 COL9A3

GO Terms for Osteochondritis Dissecans

Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.88 ACAN BMP7 COMP FBLN1 FBLN2 MMP13
2 extracellular matrix GO:0031012 9.73 ACAN BMP7 COMP FBLN1 FBLN2 MMP13
3 extracellular region GO:0005576 9.7 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP
4 endoplasmic reticulum lumen GO:0005788 9.67 COL9A1 COL9A2 COL9A3 MATN3
5 collagen trimer GO:0005581 9.62 COL9A1 COL9A2 COL9A3 MMP13
6 collagen type IX trimer GO:0005594 9.33 COL9A1 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.32 ACAN COL9A1 COL9A2 COL9A3 COMP FBLN1

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.43 BMP7 COL9A1 COMP
2 skeletal system development GO:0001501 9.35 ACAN BMP7 COL9A2 COMP MATN3
3 extracellular matrix organization GO:0030198 9.23 ACAN COL9A1 COL9A2 COL9A3 COMP FBLN1
4 growth plate cartilage development GO:0003417 9.16 COMP MMP13

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.63 ACAN COMP FBLN1 FBLN2 MATN3 MMP13
2 collagen binding GO:0005518 9.26 COMP MMP13
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL9A1 COL9A2 COL9A3
4 extracellular matrix structural constituent GO:0005201 9.02 ACAN COMP FBLN1 FBLN2 MATN3

Sources for Osteochondritis Dissecans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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