OD
MCID: OST009
MIFTS: 66

Osteochondritis Dissecans (OD) malady

Genetic diseases, Rare diseases, Bone diseases categories

Summaries for Osteochondritis Dissecans

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 In osteochondritis dissecans, a loose piece of bone and cartilage separates from the end of the bone because of a loss of blood supply. the loose piece may stay in place or fall into the joint space, making the joint unstable. this causes pain and feelings that the joint "sticks" or is "giving way." osteochondritis dissecans usually affects the knees and elbows. last updated: 6/4/2009

MalaCards: Osteochondritis Dissecans, also known as aseptic necrosis, is related to stickler syndrome and multiple epiphyseal dysplasia. An important gene associated with Osteochondritis Dissecans is ACAN (aggrecan), and among its related pathways are Gastric cancer network 2 and Elastic fibre formation. The drugs citalopram and clomipramine and the compounds neurocan and chitosan have been mentioned in the context of this disorder. Affiliated tissues include epiphysis and bone, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:9 An ischemic bone disease that results in necrosis located in epiphysis.

CDC:4 Deaths from drug overdose have been rising steadily over the past two decades and have become the leading cause of injury death in the United States.1 Ā Every day in the United States, 113 people die as a result of drug overdose, and another 6,748 are treated in emergency departments (ED) for the misuse or abuse of drugs.2 Nearly 9 out of 10 poisoning deaths are caused by drugs.3

Wikipedia:66 Osteochondritis dissecans /??sti.o?k?n?dra?t?s ?d?s?k more...

Description from OMIM:48 165800

Aliases & Classifications for Osteochondritis Dissecans

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 48OMIM, 41NCIt, 36MeSH, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases
Orphanet: 50 
Rare bone diseases


Characteristics (Orphanet epidemiological data):

50
osteochondritis dissecans:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

osteochondritis dissecans 9 44 11 50 32 63
aseptic necrosis 44 63
obsessive-compulsive disorder 63
kĆ´nig disease 50
ocd 9
od 44


External Ids:

Disease Ontology9 DOID:84
OMIM48 165800
NCIt41 C34877
MeSH36 D010007
ICD10 via Orphanet27 M93.2
SNOMED-CT via Orphanet60 82562007
UMLS via Orphanet64 C0029421
MESH via Orphanet37 D010008
ICD1026 M93.2

Related Diseases for Osteochondritis Dissecans

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1stickler syndrome30.7COL9A1, COL9A2
2multiple epiphyseal dysplasia30.6MATN3, COL9A1, COL9A3, COL9A2, ACAN
3osteosarcoma30.5MMP13, BMP7, NOTCH1, CD36
4short stature30.5MATN3, CD36
5arthritis30.2ACAN, MMP3
6osteoarthritis30.1MMP13, MMP3, CD36, NOTCH1, MATN3, COL9A1
7familial osteochondritis dissecans10.9
8obsessive-compulsive disorder10.7
9osteochondrosis10.6
10osteochondrodysplasia10.5
11osteonecrosis10.5
12legg-calve-perthes disease10.5
13periostitis10.5
14pandas10.3
15rickets10.2
16wilson disease10.2
17osgood-schlatter's disease10.2
18carpal tunnel syndrome10.2
19myopathy10.2
20dwarfism10.2
21kienbock's disease10.2
22osteochondritis of tarsal/metatarsal bone10.2
23thiemann disease, familial form10.2
24panner disease10.2
25thalassemia10.2
26spondyloepimetaphyseal dysplasia10.1MATN3
27spondylitis10.1ACAN
28spinal stenosis10.1BMP7
29agoraphobia10.1
30panic disorder10.1
31trichotillomania10.1
32pathological gambling10.1
33anxiety disorder10.1
34obsessive-compulsive disorder, protection against10.1
35spondylolisthesis10.1BMP7
36degenerative disc disease10.1COL9A3, COL9A2
37lumbar disc disease10.1COL9A3, COL9A2
38skeletal dysplasias10.1ACAN, MMP13
39diastrophic dysplasia10.1COL9A2, COL9A3, MATN3
40crohn's disease10.0
41gaucher's disease10.0
42lymphangitis10.0
43myxedema10.0
44dysbaric osteonecrosis10.0
45hemoglobinopathy10.0
46sickle cell disease10.0
47freiberg's disease10.0
48idiopathic avascular necrosis10.0
49sinding-larsen-johansson disease10.0
50abdominal aortic aneurysm10.0MMP3, MMP13

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to osteochondritis dissecans

Symptoms for Osteochondritis Dissecans

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48OMIM
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Clinical features from OMIM:

165800

Drugs & Therapeutics for Osteochondritis Dissecans

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteochondritis Dissecans

Drug clinical trials:

Search ClinicalTrials for Osteochondritis Dissecans

Search NIH Clinical Center for Osteochondritis Dissecans

Search CenterWatch for Osteochondritis Dissecans

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677
Juvenile neocartilage (RevaFlex, PMIDs: 11603712, 23465950, 20423988, 21439468, 19880363, 15742595, 21828366, 20025455

Genetic Tests for Osteochondritis Dissecans

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Anatomical Context for Osteochondritis Dissecans

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Osteochondritis Dissecans:

34
Bone

FMA organs/tissues related to Osteochondritis Dissecans:

15
Epiphysis

Animal Models for Osteochondritis Dissecans or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Osteochondritis Dissecans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6FBLN1, MMP13, ACAN, BMP7, COL9A1, MATN3
2MP:00053778.4FBLN1, ACAN, BMP7, COL9A1, NOTCH1
3MP:00053677.7FBLN1, BMP7, GAPDH, NOTCH1, CD36
4MP:00053857.1FBLN1, FBLN2, MMP13, ACAN, BMP7, GAPDH
5MP:00053877.0FBLN1, MMP3, ACAN, BMP7, COL9A1, MATN3
6MP:00053767.0MMP3, ACAN, COL9A1, GAPDH, NOTCH1, CD36
7MP:00036317.0FBLN1, TNR, MMP3, ACAN, BMP7, NOTCH1
8MP:00053786.8FBLN1, MMP13, ACAN, BMP7, MATN3, GAPDH
9MP:00053906.7CD36, FBLN1, MMP13, MMP3, ACAN, BMP7

Publications for Osteochondritis Dissecans

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Sources:
53PubMed
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Articles related to Osteochondritis Dissecans:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Drilling juvenile osteochondritis dissecans: retro- or transarticular? (22274726)
2013
2
Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. (23552666)
2013
3
Treatment of capitellar osteochondritis dissecans with a tendon graft: a case report. (22448833)
2012
4
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
5
Diagnosis and treatment of osteochondritis dissecans. (21536629)
2011
6
Bioabsorbable fixation of unstable osteochondritis dissecans lesions. (20595548)
2010
7
Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy. (20358595)
2010
8
Case report: Fresh-stored osteochondral allograft for treatment of osteochondritis dissecans the femoral head. (19727986)
2010
9
Juvenile osteochondritis dissecans of the knee. (20710085)
2010
10
Osteochondritis dissecans of the patella in a XVII century player of the Florentine historic kickball. (19729312)
2010
11
Juvenile osteochondritis dissecans of the knee: perifocal sclerotic rim as a prognostic factor of healing. (20179567)
2010
12
Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. (20032736)
2010
13
Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. (20594080)
2010
14
Association between clinical signs and histopathologic changes in the synovium of the tarsocrural joint of horses with osteochondritis dissecans of the tibia. (20043780)
2010
15
Midterm results of surgical treatment for adult osteochondritis dissecans of the knee. (19861695)
2009
16
A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. (20104156)
2009
17
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. (18310686)
2008
18
The healing potential of stable juvenile osteochondritis dissecans knee lesions. (19047711)
2008
19
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
20
Osteochondritis dissecans of the tarsal navicular. (18442463)
2008
21
Osteochondritis dissecans of the talus involving the subtalar joint: a case report. (17980849)
2007
22
Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. (17530379)
2007
23
Conservative treatment of subtalar osteochondritis dissecans: a case report. (17559774)
2007
24
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair. (16984617)
2006
25
Osteochondritis dissecans after rotational acetabular osteotomy for dysplastic hip. (15782341)
2005
26
Osteochondritis dissecans of the acetabulum: a case report. (15050205)
2004
27
Arthroscopic treatment of osteochondritis dissecans of the capitellum: Report of 5 female athletes. (12579155)
2003
28
Computed tomographic findings of osteochondritis dissecans following Legg-CalvAc-Perthes disease. (12724600)
2003
29
Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. (12355306)
2002
30
Osteochondritis dissecans of the femoral head in Perthes disease: a cause for concern? (12584979)
2002
31
Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. (11536094)
2001
32
The role of ankle arthroscopy in the treatment strategies of osteochondritis dissecans lesions of the talus. (11722142)
2001
33
Osteochondral grafting and arthroplasty for end-stage osteochondritis dissecans of the capitellum. A case report and review of the literature. (11573926)
2001
34
Closed-Wedge osteotomy for osteochondritis dissecans of the capitellum. A 7- to 12-year follow-up. (10921645)
2000
35
The arthroscopic management of osteochondritis dissecans of the adolescent elbow. (9848588)
1998
36
Osteochondritis dissecans in a young pitcher: why early recognition matters. (20086894)
1997
37
Osteochondritis dissecans of the distal femur and patella. (9012566)
1997
38
Osteochondritis dissecans of the knee. (20086997)
1996
39
Osteochondritis dissecans of the talus in identical twins. (7706361)
1995
40
Osteochondritis dissecans of the anterior tibial spine. (8305108)
1993
41
Osteochondral allografts for osteochondritis dissecans and osteonecrosis of the femoral condyles. (8500928)
1993
42
Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. (2009108)
1991
43
Injuries to the talus-neck fractures and osteochondral lesions (osteochondritis dissecans). (1875012)
1991
44
Stable osteochondritis dissecans--does the lesion unite? (2312580)
1990
45
Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography. (2605451)
1989
46
Osteochondritis dissecans of the talus: long-term results of surgical treatment. (2613129)
1989
47
Osteochondritis dissecans and other lesions of the femoral condyles. (2722949)
1989
48
Familial osteochondritis dissecans of the knee. (477064)
1979
49
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
50
Osteochondritis dissecans following Legg-Calve-Perthes disease. A report of one case. (13849850)
1960

Variations for Osteochondritis Dissecans

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Osteochondritis Dissecans:

1
id Gene Name Type Significance SNP ID Assembly Location
1ACANNM_013227.3(ACAN): c.7249G> A (p.Val2417Met)single nucleotide variantPathogenicrs267606625GRCh37Chr 15, 89416172: 89416172

Expression for genes affiliated with Osteochondritis Dissecans

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for genes affiliated with Osteochondritis Dissecans

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 13EMD Millipore, 54QIAGEN
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Pathways related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8COL9A1, COL9A3
2
Show member pathways
9.5BMP7, FBLN2, FBLN1
3
Show member pathways
9.4COL9A2, COL9A1, COL9A3
49.4COL9A1, COL9A3, COL9A2
59.4COL9A1, COL9A3, COL9A2
69.4MMP13, ACAN, BMP7
7
Show member pathways
9.3MMP13, MMP3, ACAN
8
Show member pathways
9.0COL9A3, COL9A1, COL9A2, BMP7
98.9ACAN, FBLN2, TNR, FBLN1, MMP3
108.6TNR, MATN3, COL9A1, ACAN, COL9A3, COL9A2
11
Show member pathways
8.5MMP13, MMP3, COL9A3, COL9A1, COL9A2
12
Show member pathways
8.3MMP3, NOTCH1, MMP13, BMP7
13
Show member pathways
8.2COL9A1, NOTCH1, COL9A3, BMP7, COL9A2
14
Show member pathways
8.0CD36, COL9A3, COL9A2, NOTCH1, COL9A1
15
Show member pathways
7.9MMP3, MMP13, COL9A2, COL9A1, CD36, COL9A3
16
Show member pathways
6.7MATN3, TNR, MMP13, MMP3, ACAN, FBLN2

Compounds for genes affiliated with Osteochondritis Dissecans

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1neurocan469.9ACAN, TNR, FBLN2, FBLN1
2chitosan469.8ACAN, CD36
3thermolysin469.8MMP13, MMP3
4latanoprost46 1210.8MMP3, GAPDH
5uk 383367629.7MMP13, MMP3
6clodronate46 52 1211.7CD36, MMP13
7gi 254023x629.7MMP13, MMP3
8pirfenidone46 6210.6CD36, BMP7
9gm 6001629.6MMP13, MMP3
10polyglycolic acid469.6ACAN, BMP7, CD36
11sulfonamide469.5MMP3, MMP13
12keratan sulfate469.5CD36, ACAN, MMP3
13cyanogen bromide469.4CD36, MMP13
14(4-aminophenyl)mercuric acetate469.3CD36, MMP3, MMP13
15hydroxyapatite469.3CD36, BMP7, MMP13
16prednisolone46 30 1211.3MMP13, MMP3, GAPDH
17alendronate46 52 1211.3MMP13, MMP3, CD36
18batimastat46 62 1211.3MMP13, MMP3, CD36
19agarose469.2MMP13, ACAN, BMP7, GAPDH
20glyceraldehyde 3-phosphate469.2GAPDH, ACAN, MMP3, MMP13
21glucosamine46 25 1211.1MMP13, MMP3, ACAN, CD36
22procollagen469.1MMP13, MMP3, ACAN, CD36
23glycosaminoglycan469.1CD36, ACAN, MMP3, MMP13
24safranin o469.1CD36, BMP7, ACAN, MMP3
25doxycycline46 1210.1NOTCH1, MMP3, MMP13
26hyaluronic acid46 2510.1CD36, ACAN, MMP3, MMP13
27pyridinoline469.0CD36, MMP3
28sb 20358046 6210.0MMP13, MMP3, ACAN, CD36
29nacl469.0MMP13, MMP3, BMP7
30dmso469.0CD36, GAPDH, MMP3
31vitamin d469.0MMP3, ACAN, BMP7, CD36
32ribonucleic acid468.9MMP13, MMP3, BMP7, GAPDH
33chondroitin sulfate46 259.8TNR, MMP13, MMP3, ACAN, CD36
34glutamine468.8CD36, GAPDH, COL9A2, MMP3
35alginate468.7MMP13, MMP3, ACAN, BMP7, CD36
36tgf beta1468.7MMP13, MMP3, ACAN, BMP7, CD36
37creatinine468.6CD36, GAPDH, BMP7, MMP3
38genistein46 30 62 3 25 1213.4CD36, NOTCH1, MMP3, MMP13
39cycloheximide468.3MMP13, MMP3, BMP7, GAPDH, CD36
40matrigel468.3FBLN1, MMP13, MMP3, NOTCH1, CD36
41ascorbic acid46 259.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
42pge2468.1MMP13, MMP3, ACAN, BMP7, GAPDH, CD36
43oxygen46 259.0MMP13, MMP3, BMP7, GAPDH, NOTCH1
44heparin46 30 25 1210.9FBLN1, FBLN2, MMP13, MMP3, BMP7, GAPDH
45dexamethasone46 52 30 1210.8MMP13, MMP3, ACAN, BMP7, NOTCH1, CD36
46vegf467.5MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
47serine467.4MMP13, MMP3, BMP7, GAPDH, NOTCH1, CD36
48retinoic acid46 258.3MMP13, MMP3, ACAN, BMP7, GAPDH, NOTCH1
49estrogen467.3FBLN1, MMP13, MMP3, BMP7, GAPDH, NOTCH1
50calcium46 52 25 1210.0FBLN1, FBLN2, TNR, MMP13, MMP3, BMP7

GO Terms for genes affiliated with Osteochondritis Dissecans

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17Gene Ontology
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Cellular components related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.4COL9A1, COL9A3, COL9A2
2collagen type IXGO:0055949.3COL9A1, COL9A3, COL9A2
3extracellular matrixGO:0310129.0FBLN1, FBLN2, ACAN, BMP7
4proteinaceous extracellular matrixGO:0055788.2FBLN1, FBLN2, TNR, MMP13, MMP3, ACAN
5extracellular regionGO:0055765.9NOTCH1, FBLN1, FBLN2, TNR, MMP13, MMP3

Biological processes related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of removal of superoxide radicalsGO:20001219.5BMP7, CD36
2skeletal system developmentGO:0015019.3MATN3, COL9A2, BMP7, ACAN
3proteolysisGO:0065089.2MMP13, MMP3, ACAN
4negative regulation of neurogenesisGO:0507689.2NOTCH1, BMP7
5epithelial to mesenchymal transitionGO:0018379.2NOTCH1, BMP7
6branching morphogenesis of an epithelial tubeGO:0487548.9NOTCH1, BMP7
7axon guidanceGO:0074118.8TNR, BMP7, COL9A2, COL9A3, COL9A1
8collagen catabolic processGO:0305748.7MMP13, MMP3, COL9A2, COL9A3, COL9A1
9extracellular matrix disassemblyGO:0226178.5MMP13, MMP3, ACAN, COL9A2, COL9A3, COL9A1
10extracellular matrix organizationGO:0301986.9MATN3, FBLN1, FBLN2, TNR, MMP13, MMP3

Molecular functions related to Osteochondritis Dissecans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.3COL9A1, COL9A3, COL9A2
2extracellular matrix structural constituentGO:0052019.1FBLN1, FBLN2, ACAN, MATN3
3calcium ion bindingGO:0055098.2NOTCH1, MMP3, MMP13, FBLN2, FBLN1

Products for genes affiliated with Osteochondritis Dissecans

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondritis Dissecans

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet