MCID: OST009
MIFTS: 52

Osteochondritis Dissecans

Categories: Rare diseases, Bone diseases, Genetic diseases

Aliases & Classifications for Osteochondritis Dissecans

MalaCards integrated aliases for Osteochondritis Dissecans:

Name: Osteochondritis Dissecans 38 12 50 56 29 42 14 69
Osteochondritis 42 69
König Disease 50 56
Kônig Disease 50
Ocd 12

Characteristics:

Orphanet epidemiological data:

56
osteochondritis dissecans
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:84
ICD10 33 M93.2 M93.9
ICD9CM 35 732.7
Orphanet 56 ORPHA2764
MESH via Orphanet 43 D010008
UMLS via Orphanet 70 C0029421
ICD10 via Orphanet 34 M93.2

Summaries for Osteochondritis Dissecans

NIH Rare Diseases : 50 osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. if the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. however, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. in most cases, the exact underlying cause is unknown. rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the acan gene and is inherited in an autosomal dominant manner. treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy. last updated: 2/8/2015

MalaCards based summary : Osteochondritis Dissecans, also known as osteochondritis, is related to osteochondrosis and osteonecrosis, and has symptoms including joint stiffness, limited elbow extension and arthralgia. An important gene associated with Osteochondritis Dissecans is ACAN (Aggrecan), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Fibrin Tissue Adhesive and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are limbs/digits/tail and hearing/vestibular/ear

Disease Ontology : 12 An ischemic bone disease that results_in necrosis located in epiphysis.

Wikipedia : 72 Osteochondritis dissecans (OCD or OD) is a joint disorder in which cracks form in the articular... more...

Related Diseases for Osteochondritis Dissecans

Diseases in the Osteochondritis Dissecans family:

Familial Osteochondritis Dissecans

Diseases related to Osteochondritis Dissecans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 osteochondrosis 28.3 ACAN COL9A1 COMP MATN3 MMP13 MMP3
2 osteonecrosis 24.5 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP
3 familial osteochondritis dissecans 12.6
4 osteochondritis dissecans, short stature, and early-onset osteoarthritis 12.6
5 obsessive-compulsive disorder 11.5
6 pandas 11.1
7 trichotillomania 11.1
8 gilles de la tourette syndrome 11.1
9 central cord syndrome 10.5 COL9A2 COL9A3
10 cerebral hemorrhage 10.5 ACAN COMP
11 smed strudwick type 10.5 ACAN COMP
12 vulvar sarcoma 10.4 ACAN COMP
13 acromesomelic dysplasia 10.4 ACAN COMP
14 atrioventricular septal defect 10.4 COL9A2 COMP
15 osteoarthritis 10.3
16 benign familial mesial temporal lobe epilepsy 10.3 COL9A1 COL9A2 COL9A3
17 hemolytic anemia due to glutathione synthetase deficiency 10.3 COMP MMP3
18 dysmorphism-short stature-deafness-disorder of sex development syndrome 10.2 COL9A1 COL9A2 COL9A3
19 epileptic encephalopathy, early infantile, 7 10.2 COL9A2 COL9A3
20 charcot-marie-tooth disease type 5 10.2 COL9A1 COL9A2 COL9A3
21 periostitis 10.2
22 hypochondroplasia 10.2 ACAN COMP
23 multiple epiphyseal dysplasia 10.2
24 legg-calve-perthes disease 10.2
25 charcot-marie-tooth disease, axonal, type 2cc 10.1 MMP13 MMP3
26 thiemann disease 10.1
27 kohler's disease 10.1
28 osgood-schlatter's disease 10.1
29 kienbock's disease 10.1
30 corpus callosum agenesis of blepharophimosis robin type 10.1 MMP13 MMP3
31 dengue hemorrhagic fever 10.1 ACAN COL9A3 MMP3
32 stickler syndrome 10.1
33 systemic mastocytosis 10.1 BMP7 MMP3
34 sulfite oxidase deficiency 10.0 COMP MMP13
35 spondyloepiphyseal dysplasia tarda 9.9
36 rickets 9.9
37 epicondylitis 9.9
38 myopathy 9.9
39 wilson disease 9.9
40 dwarfism 9.9
41 slc6a4-related altered drug metabolism 9.9 ACAN COMP
42 synovium cancer 9.9 COMP MMP13 MMP3
43 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 9.9 ACAN FBLN1 FBLN2
44 atherosclerosis 9.8 ACAN MMP13 MMP3
45 skin fragility-woolly hair-palmoplantar keratoderma syndrome 9.7 COMP MATN3
46 ischemic bone disease 9.7 COL9A2 COMP MATN3
47 spondyloepimetaphyseal dysplasia 9.7 ACAN MATN3 MMP13
48 mesenchymal cell neoplasm 9.6 ACAN COMP MMP13 MMP3
49 spondylolisthesis 8.9 ACAN BMP7 COL9A1 COL9A2 COL9A3 MMP3
50 bone structure disease 8.9 ACAN BMP7 COL9A2 COL9A3 MMP13 MMP3

Graphical network of the top 20 diseases related to Osteochondritis Dissecans:



Diseases related to Osteochondritis Dissecans

Symptoms & Phenotypes for Osteochondritis Dissecans

Human phenotypes related to Osteochondritis Dissecans:

32 (show all 11)
id Description HPO Frequency HPO Source Accession
1 joint stiffness 32 hallmark (90%) HP:0001387
2 limited elbow extension 32 frequent (33%) HP:0001377
3 arthralgia 32 hallmark (90%) HP:0002829
4 gait disturbance 32 occasional (7.5%) HP:0001288
5 joint swelling 32 hallmark (90%) HP:0001386
6 limited elbow flexion 32 frequent (33%) HP:0006376
7 decreased hip abduction 32 frequent (33%) HP:0003184
8 quadriceps muscle atrophy 32 occasional (7.5%) HP:0009050
9 abnormality of the knee 32 hallmark (90%) HP:0002815
10 abnormality of tibia morphology 32 occasional (7.5%) HP:0002992
11 abnormality of skeletal physiology 32 frequent (33%) HP:0011843

MGI Mouse Phenotypes related to Osteochondritis Dissecans:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.5 BMP7 COL9A1 COL9A2 COMP FBLN1 MATN3
2 hearing/vestibular/ear MP:0005377 9.46 BMP7 COL9A1 COL9A2 FBLN1
3 skeleton MP:0005390 9.23 COMP FBLN1 MATN3 MMP13 MMP3 BMP7

Drugs & Therapeutics for Osteochondritis Dissecans

Drugs for Osteochondritis Dissecans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 3
2 Mitogens Phase 3
3 Astragalus Nutraceutical

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD) Withdrawn NCT01283737 Phase 4
2 Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture Unknown status NCT01498029 Phase 3
3 A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects. Completed NCT02993510 Phase 3
4 ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782 Phase 2, Phase 3
5 Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
6 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
7 Repair of Articular Osteochondral Defect Unknown status NCT01409447
8 Study of the Effect of Weight Bearing Status on Patient Outcomes After Surgery for Osteochondral Defects of the Ankle Unknown status NCT01405664
9 Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee Unknown status NCT01159899 Early Phase 1
10 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976
11 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298
12 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278 Platelet rich plasma (PRP)
13 Osteochondritis Dissecans of Knee Prospective Cohort Recruiting NCT02771496
14 Conjoint Analysis of Patient Preferences in Joint Interventions Recruiting NCT02664337
15 Evaluation of the Agili-C Biphasic Implant in the Knee Joint Active, not recruiting NCT01471236
16 DeNovo NT Longitudinal Data Collection (LDC) Knee Study Active, not recruiting NCT01329445
17 DeNovo NT Ankle LDC Study Active, not recruiting NCT01347892
18 MRI Findings of Epiphyseal Growth Plate in Healthy Children Not yet recruiting NCT03190200
19 Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration Terminated NCT00881023
20 Chondrofix Osteochondral Allograft Prospective Study Terminated NCT01410136

Search NIH Clinical Center for Osteochondritis Dissecans

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondritis Dissecans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondritis Dissecans:
DeNovo NT
JACC
RevaFlex
Embryonic/Adult Cultured Cells Related to Osteochondritis Dissecans:
Cultured cartilage (JACC PMIDs: 16233778 19393556 10738867 16226641 11284883 12043781 16233853 19802670 10679677
Juvenile neocartilage (RevaFlex PMIDs: 11603712 23465950 20423988 21439468 19880363 15742595 21828366 20025455

Cochrane evidence based reviews: osteochondritis dissecans

Genetic Tests for Osteochondritis Dissecans

Genetic tests related to Osteochondritis Dissecans:

id Genetic test Affiliating Genes
1 Osteochondritis Dissecans 29

Anatomical Context for Osteochondritis Dissecans

MalaCards organs/tissues related to Osteochondritis Dissecans:

39
Bone, Bone Marrow

Publications for Osteochondritis Dissecans

Articles related to Osteochondritis Dissecans:

(show top 50) (show all 645)
id Title Authors Year
1
Osteochondritis Dissecans: Etiology, Pathology, and Imaging with a Special Focus on the Knee Joint. ( 28639852 )
2017
2
Osteochondritis dissecans located on the medial tibial plateau: a case report. ( 28049517 )
2017
3
Anconeus Muscle-Pedicle Bone Graft With Periosteal Coverage for Osteochondritis Dissecans of the Humeral Capitellum. ( 28944252 )
2017
4
Osteochondritis dissecans of the capitellum: lesion size and pattern analysis using quantitative 3-dimensional computed tomography and mapping technique. ( 28478896 )
2017
5
The Reliability of Assessing Radiographic Healing of Osteochondritis Dissecans of the Knee. ( 28398084 )
2017
6
Donor-site morbidity after osteochondral autologous transplantation for osteochondritis dissecans of the capitellum: a systematic review and meta-analysis. ( 28391550 )
2017
7
Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County. ( 28711583 )
2017
8
Osteochondritis Dissecans of the Capitellum: A Case Report of Successful Arthroscopic Treatment. ( 28458937 )
2017
9
Management of Osteochondritis Dissecans Lesions of the Knee, Elbow and Ankle. ( 28577707 )
2017
10
Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold. ( 28706836 )
2017
11
Nonoperative Management of Osteochondritis Dissecans of the Knee: Progression to Osteoarthritis and Arthroplasty at Mean 13-Year Follow-up. ( 28812032 )
2017
12
Radiographic comparison of adolescent athletes with elbow osteochondritis dissecans to ulnar collateral ligament injuries and controls. ( 28087165 )
2017
13
Osteochondritis Dissecans Development. ( 28551287 )
2017
14
High Rate of Osteoarthritis After Osteochondritis Dissecans Fragment Excision Compared With Surgical Restoration at a Mean 16-Year Follow-up. ( 28419816 )
2017
15
Osteochondritis Dissecans of the Humeral Head: A Case Report and Review of the Literature. ( 28271091 )
2017
16
Modyfied wedge osteotomy for osteoarthritis of elbow secondary to osteochondritis dissecans in adolecent with multiple epiphyseal dysplasia. A case report. ( 28860685 )
2017
17
Clinical Outcome After Arthroscopic Debridement and Microfracture for Osteochondritis Dissecans of the Capitellum. ( 28520461 )
2017
18
Focal Defects of the Knee Articular Surface: Evidence of a Regenerative Potential Pattern in Osteochondritis Dissecans and Degenerative Lesions. ( 28770227 )
2017
19
Age-Specific Prevalence and Clinical Characteristics of Humeral Medial Epicondyle Apophysitis and Osteochondritis Dissecans: Ultrasonographic Assessment of 4249 Players. ( 28589162 )
2017
20
Predictive factors for osteochondritis dissecans of the lateral femoral condyle concurrent with a discoid lateral meniscus. ( 28197693 )
2017
21
Osteochondritis Dissecans of the Humeral Capitellum in Young Athletes: Comparison Between Baseball Players and Gymnasts. ( 28321431 )
2017
22
The effect of autologous adipose derived mesenchymal stem cell therapy in the treatment of a large osteochondral defect of the knee following unsuccessful surgical intervention of osteochondritis dissecans - a case study. ( 28705162 )
2017
23
Arthroscopy of the Dorsal and Plantar Pouches of the Tarsocrural Joint for the Treatment of Osteochondritis Dissecans in the Horse: Clinical Features and Follow-Up. ( 27684059 )
2016
24
Osteochondritis dissecans of the capitellum in adolescents. ( 26925381 )
2016
25
Progression of stable juvenile osteochondritis dissecans after 10 years of meniscectomy of the discoid lateral meniscus. ( 27028045 )
2016
26
Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency? ( 27600715 )
2016
27
Osteochondritis Dissecans of the Capitellum: Diagnosis and Treatment. ( 26977547 )
2016
28
Arthroscopic Autologous Chondrocyte Transplantation for Osteochondritis Dissecans of theA Elbow. ( 27656389 )
2016
29
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly. ( 27388238 )
2016
30
Novel Arthroscopic Classification of Osteochondritis Dissecans of the Knee: A Multicenter Reliability Study. ( 27159302 )
2016
31
Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. ( 27018370 )
2016
32
The Incidence of Surgery in Osteochondritis Dissecans in Children and Adolescents. ( 27047984 )
2016
33
Osteochondritis Dissecans of the Humeral Capitellum Associated with a Large Subchondral Bone Cyst: Two Cases Report. ( 27454643 )
2016
34
Mosaicplasty for femoral osteochondritis dissecans. ( 26896409 )
2016
35
Treatment of Osteochondritis Dissecans of the Talus in Skeletally Immature Population: A Critical Analysis of the Available Evidence. ( 27044597 )
2016
36
Current Concepts in Treatment of Patellofemoral Osteochondritis Dissecans. ( 27904793 )
2016
37
Osteochondritis dissecans of the elbow. ( 27125506 )
2016
38
Autologous osteochondral mosaicplasty in osteochondritis dissecans of the patella in adolescents. ( 27118373 )
2016
39
Catcher's Knee: Posterior Femoral Condyle Juvenile Osteochondritis Dissecans in Children and Adolescents. ( 27442212 )
2016
40
Return to Sport After Operative Management of Osteochondritis Dissecans of the Capitellum: A Systematic Review and Meta-analysis. ( 27482526 )
2016
41
Internal Fixation of Unstable Osteochondritis Dissecans in the Skeletally Mature Knee with Metal Screws. ( 27047638 )
2016
42
Viability of Cells From Displaced Fragments of the Elbow Osteochondritis Dissecans: Alternative Source of Autologous Chondrocyte Implantation. ( 27956231 )
2016
43
From loose body to osteochondritis dissecans: a historical account of disease definition. ( 27900309 )
2016
44
Bone-peg grafting for osteochondritis dissecans of the humeral capitellum. ( 27122513 )
2016
45
Insights into the Epiphyseal Cartilage Origin and Subsequent Osseous Manifestation of Juvenile Osteochondritis Dissecans with a Modified Clinical MR Imaging Protocol: A Pilot Study. ( 27631413 )
2016
46
Fresh osteochondral allograft transplantation for osteochondritis dissecans of the capitellum in baseball players. ( 27742247 )
2016
47
Prevalence of Capitellar Osteochondritis Dissecans in Children With Chronic Radial Head Subluxation and Dislocation. ( 27010446 )
2016
48
Magnetic Resonance Imaging of Osteochondritis Dissecans: Validation Study for the ICRS Classification System. ( 26976624 )
2016
49
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. ( 27283998 )
2016
50
Management of Osteochondritis Dissecans of the Femoral Condyle. ( 27479835 )
2016

Variations for Osteochondritis Dissecans

ClinVar genetic disease variations for Osteochondritis Dissecans:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ACAN NM_013227.3(ACAN): c.7249G> A (p.Val2417Met) single nucleotide variant Pathogenic rs267606625 GRCh37 Chromosome 15, 89416172: 89416172

Expression for Osteochondritis Dissecans

Search GEO for disease gene expression data for Osteochondritis Dissecans.

Pathways for Osteochondritis Dissecans

Pathways related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 ACAN COL9A1 COL9A2 COL9A3 MMP13 MMP3
2
Show member pathways
12.75 ACAN BMP7 COL9A1 COL9A2 COL9A3
3
Show member pathways
12.58 COL9A1 COL9A2 COL9A3 COMP
4
Show member pathways
12.49 COL9A1 COL9A2 COL9A3 MMP13 MMP3
5 12.37 COL9A1 COL9A2 COL9A3 COMP
6
Show member pathways
12.02 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP
7
Show member pathways
11.73 COL9A1 COL9A2 COL9A3 COMP
8
Show member pathways
11.47 BMP7 FBLN1 FBLN2
9 11.39 ACAN BMP7 MMP13
10 11.33 MMP13 MMP3
11 11.19 ACAN COL9A1 COL9A2 COL9A3 COMP MATN3
12 11.1 ACAN COMP
13 11.07 COL9A1 COL9A2 COL9A3
14 11.05 ACAN FBLN1 FBLN2 MMP3
15 11.01 COL9A1 COL9A3

GO Terms for Osteochondritis Dissecans

Cellular components related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 ACAN BMP7 COMP FBLN1 FBLN2 MMP13
2 endoplasmic reticulum lumen GO:0005788 9.71 COL9A1 COL9A2 COL9A3 MATN3
3 extracellular matrix GO:0031012 9.7 ACAN BMP7 COMP FBLN1 FBLN2 MMP13
4 extracellular region GO:0005576 9.7 ACAN BMP7 COL9A1 COL9A2 COL9A3 COMP
5 collagen trimer GO:0005581 9.62 COL9A1 COL9A2 COL9A3 MMP13
6 collagen type IX trimer GO:0005594 9.43 COL9A1 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.32 ACAN COL9A1 COL9A2 COL9A3 COMP FBLN1

Biological processes related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.5 BMP7 COL9A1 COMP
2 extracellular matrix disassembly GO:0022617 9.43 ACAN MMP13 MMP3
3 skeletal system development GO:0001501 9.35 ACAN BMP7 COL9A2 COMP MATN3
4 extracellular matrix organization GO:0030198 9.17 ACAN COL9A1 COL9A2 COL9A3 COMP FBLN1
5 growth plate cartilage development GO:0003417 9.16 COMP MMP13

Molecular functions related to Osteochondritis Dissecans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.63 ACAN COMP FBLN1 FBLN2 MATN3 MMP13
2 collagen binding GO:0005518 9.26 COMP MMP13
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL9A1 COL9A2 COL9A3
4 extracellular matrix structural constituent GO:0005201 9.02 ACAN COMP FBLN1 FBLN2 MATN3

Sources for Osteochondritis Dissecans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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