MCID: OST028
MIFTS: 40

Osteochondroma malady

Genetic diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Osteochondroma

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Sources:
45NIH Rare Diseases, 47Novoseek, 65UMLS
See all sources

Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 45 47
 
Cartilaginous Exostosis 65


Classifications:



Summaries for Osteochondroma

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Wikipedia:68 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to chondrosarcoma and muenke syndrome. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and VEGF Signaling. Affiliated tissues include bone, spinal cord and testes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Related Diseases for Osteochondroma

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Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.0EXT1, EXT2, FGF2, PTHLH
2muenke syndrome30.4FGFR1, FGFR3
3cervicitis10.7
4hereditary multiple osteochondromas10.6
5hereditary multiple exostoses10.5
6exostosis10.5
7dysplastic cortical hyperostosis10.3EXT1, EXT2
8hereditary paraganglioma-pheochromocytoma syndromes10.3EXT1, EXT2
9metachondromatosis10.3
10bursitis10.3
11dysplasia epiphysealis hemimelica10.3
12synovial chondromatosis10.3
13anterior compartment syndrome10.3EXT1, PTHLH
14lateral myocardial infarction10.3EXT2, PTHLH
15chondroma10.3
16adams-oliver syndrome10.3EXT1, EXT2, PTHLH
17type c thymoma10.3EXT1, PTHLH
18flna-related periventricular nodular heterotopia10.3FGFR1, FGFR3
19body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.3S100B, VIM
20plagiocephaly and x-linked mental retardation10.3FGFR1, FGFR3
21hypersomnia10.2S100B, VIM
22hydranencephaly10.2EXT1, EXT2, PTHLH
23fibrodysplasia ossificans progressiva10.2
24enchondroma10.2
25thyroid carcinoma with thyrotoxicosis10.2BCL2, VIM
26beemer ertbruggen syndrome10.2S100B, VIM
27osteoglophonic dysplasia10.2FGFR1, FGFR3
28lymphangiosarcoma10.2S100B, VIM
29gallbladder endocrine tumor10.2S100B, VIM
30lung oat cell carcinoma10.2S100B, VIM
31familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement10.2S100B, VIM
32ophthalmia neonatorum10.2S100B, VIM
33portal hypertension10.2S100B, VIM
34benign multicystic peritoneal mesothelioma10.2BCL2, VIM
35differentiating neuroblastoma10.2S100B, VIM
36clivus chordoma10.2S100B, VIM
37acute allergic sanguinous otitis media10.2BCL2, CDKN1A
38carotenemia10.2NES, VIM
39pseudoarthrosis10.2
40aneurysm10.2
41basal cell carcinoma 710.2S100B, VIM
42epidemic typhus10.2NES, VIM
43uterine corpus serous adenocarcinoma10.2S100B, VIM
44vulvar clear cell hidradenocarcinoma10.2S100B, VIM
45ladd syndrome10.2FGF9, FGFR1, FGFR3
46subependymal giant cell astrocytoma10.2S100B, VIM
47acrodermatitis10.2FGF2, FGFR1, FGFR3
48thanatophoric dysplasia, type i10.2FGF2, FGFR1, FGFR3
49high molecular weight kininogen deficiency10.1BCL2, S100B, VIM
50crouzon syndrome10.1FGF2, FGFR1, FGFR3

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms for Osteochondroma

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Drugs & Therapeutics for Osteochondroma

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Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tramadolapproved, investigationalPhase 419527203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Conzip
Crispin
D08623
DB00193
Durela
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
LS-57116
 
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
Ryzolt
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol Hydrochloride
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol
2
Etoricoxibapproved, investigationalPhase 488202409-33-4123619
Synonyms:
202409-33-4
5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-2-(6-Methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
5-chloro-6'-Methyl-3-(P-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
5CH
AC1L3WZM
Algix
Arcoxia
C11718
C422649
CHEBI:106706
CHEBI:6339
CHEMBL416146
CID123619
D03710
DB01628
DB07166
ETORICOXIB
 
Etoricoxib
Etoricoxib (USAN/INN)
Etoricoxib [USAN:INN:BAN]
Etoricoxibe
Etoricoxibum
FT-0082494
HMS2090A05
L-791456
L001141
L791456
LS-181802
MK 0663
MK 663
MK-0663
MK-663
Merck Sharp & Dohme brand of etoricoxib
MolPort-003-847-339
NCGC00164578-01
Nucoxia
Tauxib
UNII-WRX4NFY03R
ZINC00579472
3Cyclooxygenase 2 InhibitorsPhase 4517

Interventional clinical trials:

idNameStatusNCT IDPhase
1The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus SurgeryCompletedNCT00733421Phase 4
2Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
3A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus TendonRecruitingNCT01341509Phase 4
4Autologous Stem Cells in Achilles TendinopathyNot yet recruitingNCT02064062Phase 2
5The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
6Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and KneeCompletedNCT01771393
7A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
8Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
9Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
10Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Anatomical Context for Osteochondroma

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MalaCards organs/tissues related to Osteochondroma:

33
Bone, Spinal cord, Testes, Tongue, Uterus, Liver, Lymph node

Animal Models for Osteochondroma or affiliated genes

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MGI Mouse Phenotypes related to Osteochondroma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7BCL2, CDKN1A, FGFR1, FGFR3, PTHLH, TGFB2
2MP:00020068.5BCL2, CDKN1A, E2F1, EXT1, FGF2, FGFR3
3MP:00053887.7BCL2, CDKN1A, E2F1, FGF9, FGFR3, PTHLH
4MP:00107717.6BCL2, CDKN1A, E2F1, EXT1, FGF9, FGFR1
5MP:00053697.6BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
6MP:00053717.5BMP2, BMPR1B, CDKN1A, EXT1, FGF9, FGFR1
7MP:00053797.4BCL2, BMPR1B, CDKN1A, E2F1, FGF9, FGFR1
8MP:00053827.2BCL2, BMP2, BMPR1B, CDKN1A, EXT1, FGF9
9MP:00053816.8BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF9
10MP:00053776.8BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF2
11MP:00053916.6BCL2, BMPR1B, CDKN1A, E2F1, EXT1, FGF2
12MP:00053806.6BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
13MP:00053856.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
14MP:00053866.5BCL2, CDKN1A, E2F1, EXT1, FGF2, FGF9
15MP:00053906.4BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
16MP:00053766.3BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
17MP:00053895.8BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2
18MP:00053785.7BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
19MP:00053845.5BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
20MP:00036315.4BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
21MP:00107685.2BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1

Publications for Osteochondroma

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Articles related to Osteochondroma:

(show top 50)    (show all 633)
idTitleAuthorsYear
1
Subacromial osteochondroma: A rare cause of impingement syndrome. (25528042)
2015
2
Osteochondroma in long-term survivors of high-risk neuroblastoma. (25728463)
2015
3
Osteochondroma of the glenoid fossa-report of two cases with sudden onset of symptoms. (25277805)
2014
4
Low condylectomy and orthognathic surgery to treat mandibular condylar osteochondroma: a retrospective review of 37 cases. (24997022)
2014
5
Osteochondroma of the palate: An interesting and an unusual case presentation. (25328318)
2014
6
Synovial chondromatosis of pes anserine bursa secondary to osteochondroma. (25102510)
2014
7
Letter regarding "Effect of osteochondroma location on forearm deformity in patients with multiple hereditary osteochondromatosis". (23790427)
2013
8
Transformation of solitary osteochondroma to dedifferentiated chondrosarcoma arising in the distal radius: a case report. (23007379)
2013
9
Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas. (23412166)
2013
10
Osteochondroma of mandibular condyle: A clinic-radiographic correlation. (24082753)
2013
11
Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas. (24009674)
2013
12
Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency. (23384194)
2013
13
Solitary osteochondroma arising from cervical spina bifida occulta. (24383028)
2013
14
Osteochondroma of the temporomandibular joint: report of 2 cases emphasizing the importance of personalizing the surgical treatment. (22669156)
2012
15
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (22246151)
2012
16
Isolated osteochondroma of the femoral neck presenting as hip and leg pain. A case study. (22619103)
2012
17
Malignant degeneration of a lumbar osteochondroma into a chondrosarcoma which mimicked a large retropertioneal mass. (22526879)
2012
18
3-D printout of a DICOM file to aid surgical planning in a 6 year old patient with a large scapular osteochondroma complicating congenital diaphyseal aclasia. (22690278)
2012
19
A synovial osteochondroma replacing the anterior cruciate ligament at the intercondylar notch. (21323282)
2011
20
Computer-assisted surgical planning and simulation for condylar reconstruction in patients with osteochondroma. (20427106)
2011
21
Scapular osteochondroma treated with arthroscopic excision using prone positioning. (20396684)
2010
22
Cervical spine osteochondroma: rare presentation of a common lesion. (21109061)
2010
23
Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. (20012156)
2010
24
A rare anterior sacral osteochondroma presenting as sciatica in an adult: a case report and review of the literature. (20421072)
2010
25
Resected osteochondroma of the rib in an elderly patient. (21069500)
2010
26
A multilobed osteochondroma of the hamate: case report. (19695798)
2009
27
Osteochondroma of the mandibular condyle: Resection and reconstruction using vertical sliding osteotomy of the mandibular ramus. (19333189)
2009
28
Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. (18196252)
2008
29
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. (17301954)
2007
30
Phalangeal osteochondroma. (17323627)
2007
31
Discomfort during sexual intercourse secondary to osteochondroma: a report of two cases. (17588798)
2007
32
Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. (17226760)
2007
33
Osteochondroma of the skull base. (17599588)
2007
34
An optimized DHPLC protocol for molecular testing of the EXT1 and EXT2 genes in hereditary multiple osteochondromas. (16283885)
2005
35
A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica? (14564279)
2003
36
Extraskeletal osteochondroma of the buttock. (12589103)
2003
37
Condylar osteochondroma with complete hearing loss: report of a case. (12524621)
2003
38
Arterial compromise caused by lower limb osteochondroma. (12799727)
2003
39
Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage. (12472121)
2002
40
Osteochondroma of the posterior nasal septum managed by endoscopic transnasal transseptal approach. (12487678)
2002
41
Two cases of osteochondroma recurrence after surgical resection. (11198832)
2001
42
Osteochondroma of the C5 lamina with cord compression: case report and review of the literature. (10806510)
2000
43
Cervical myelopathy due to an osteochondroma in a 73-year-old female. The oldest case in the literature. (10983260)
2000
44
Osteochondroma of the tracheal wall in a Fischer's lovebird (Agapornis fischeri, Reichenow 1887). (10216774)
1999
45
Scaphoid osteochondroma. (9457602)
1997
46
Dysplasia epiphysealis hemimelica. Upper limb involvement with associated osteochondroma. (7924021)
1994
47
Cervical osteochondroma (C2 level) with vertebral artery occlusion and second cervical nerve root irritation. (2718087)
1989
48
Osteochondroma with thoracic cord compression in hereditary multiple exostoses: a case report. (312508)
1979
49
Osteochondroma of the cervical spine: a cause of transient quadriplegia. (460559)
1979
50
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. (5803809)
1969

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGF2, FGFR1, FGFR3
2
Show member pathways
9.5FGF2, FGFR1, FGFR3
39.5FGF2, FGFR1, FGFR3
4
Show member pathways
9.3BCL2, BMPR1B, FGFR1, FGFR3
5
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
6
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
7
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
8
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
9
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
10
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
119.2FGF2, FGFR1, TGFB2
129.2CDKN1A, E2F1, FGFR3
139.1BCL2, CDKN1A, E2F1
14
Angiogenesis (CST)
Show member pathways
9.0BCL2, CDKN1A, E2F1
15
TGF-beta signaling pathway (KEGG)
Show member pathways
8.9BCL2, CDKN1A, E2F1
16
TGF-beta Signaling Pathway (sino)
Show member pathways
8.9BCL2, CDKN1A, E2F1
178.8CDKN1A, FGF2, FGFR1, TGFB2
188.8FGF2, FGFR1, FGFR3, PTHLH, TGFB2
198.8FGF2, FGF9, FGFR1, FGFR3, TGFB2
208.8CDKN1A, E2F1, FGFR1, FGFR3
218.5BCL2, CDKN1A, FGF2, FGF9, FGFR1, FGFR3
228.4BMP2, BMPR1B, FGF2, FGFR1, FGFR3
238.4BCL2, CDKN1A, E2F1, FGF2, FGFR1
248.3BCL2, BMP2, CDKN1A, E2F1
25
Show member pathways
8.2BMP2, FGF2, FGFR1, FGFR3, TGFB2
26
Show member pathways
8.1BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
278.0BCL2, CDKN1A, E2F1, FGFR3, TGFB2, VIM
28
Show member pathways
7.9BMP2, BMPR1B, E2F1, FGF2, TGFB2
29
Show member pathways
7.6BCL2, BMP2, BMPR1B, FGF2, FGFR1, FGFR3
30
Show member pathways
7.2BCL2, BMP2, BMPR1B, CDKN1A, FGF2, FGFR1
31
Show member pathways
6.6BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
326.6BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
33
Show member pathways
6.2BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2

GO Terms for genes affiliated with Osteochondroma

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Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.4BMP2, FGF2, FGF9, FGFR1, FGFR3, PTHLH

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:003369210.8EXT1, EXT2
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:009008010.6FGFR1, FGFR3
3lens fiber cell developmentGO:007030710.5FGFR3, VIM
4heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:001501410.5EXT1, EXT2
5lung-associated mesenchyme developmentGO:006048410.5FGF9, FGFR1
6positive regulation of phospholipase C activityGO:001086310.5FGF2, FGFR1
7organ inductionGO:000175910.5FGF2, FGFR1
8positive regulation of phospholipase activityGO:001051810.4FGFR1, FGFR3
9substantia nigra developmentGO:002176210.3FGF2, FGF9, FGFR3
10positive regulation of cardiac muscle cell proliferationGO:006004510.2FGF2, FGF9, FGFR1
11salivary gland morphogenesisGO:000743510.2FGFR1, TGFB2
12positive regulation of cell divisionGO:005178110.1FGF2, FGF9, TGFB2
13corticotropin hormone secreting cell differentiationGO:006012810.0BMP2, FGF2
14thyroid-stimulating hormone-secreting cell differentiationGO:006012910.0BMP2, FGF2
15eye developmentGO:000165410.0BMPR1B, FGF9, TGFB2
16ossificationGO:000150310.0BCL2, EXT1, EXT2
17lung developmentGO:003032410.0FGF2, FGF9, FGFR1
18response to glucocorticoidGO:005138410.0BCL2, CDKN1A, S100B
19positive regulation of cartilage developmentGO:00610369.9BMP2, BMPR1B
20mesenchymal cell differentiationGO:00487629.9BMP2, FGFR1
21cardiac epithelial to mesenchymal transitionGO:00603179.8BMP2, TGFB2
22pathway-restricted SMAD protein phosphorylationGO:00603899.8BMP2, TGFB2
23positive regulation of ossificationGO:00457789.7BMP2, TGFB2
24MAPK cascadeGO:00001659.6FGF2, FGF9, FGFR1, FGFR3
25activation of MAPKK activityGO:00001869.6FGF2, FGF9, FGFR1, FGFR3
26positive regulation of endothelial cell proliferationGO:00019389.6BMP2, FGF2, FGFR3
27intrinsic apoptotic signaling pathwayGO:00971939.6BCL2, CDKN1A, E2F1
28branching involved in ureteric bud morphogenesisGO:00016589.6BCL2, BMP2, FGF2
29positive regulation of osteoblast differentiationGO:00456699.6BMP2, BMPR1B, FGF2
30growthGO:00400079.5BCL2, BMP2, TGFB2
31angiogenesisGO:00015259.5FGF2, FGF9, FGFR1, TGFB2
32positive regulation of cell differentiationGO:00455979.4BMP2, BMPR1B, FGF2, FGFR3
33SMAD protein signal transductionGO:00603959.4BMP2, TGFB2, VIM
34phosphatidylinositol-mediated signalingGO:00480159.4CDKN1A, FGF2, FGF9, FGFR1, FGFR3
35vascular endothelial growth factor receptor signaling pathwayGO:00480109.3FGF2, FGF9, FGFR1, FGFR3
36regulation of cell cycleGO:00517269.2BCL2, CDKN1A, E2F1, FGF2
37cell-cell signalingGO:00072679.2BMP2, FGF9, PTHLH, TGFB2
38Ras protein signal transductionGO:00072659.2CDKN1A, FGF2, FGF9, FGFR1, FGFR3
39fibroblast growth factor receptor signaling pathwayGO:00085439.1CDKN1A, FGF2, FGF9, FGFR1, FGFR3
40Fc-epsilon receptor signaling pathwayGO:00380959.1CDKN1A, FGF2, FGF9, FGFR1, FGFR3
41neurotrophin TRK receptor signaling pathwayGO:00480119.1CDKN1A, FGF2, FGF9, FGFR1, FGFR3
42epidermal growth factor receptor signaling pathwayGO:00071738.8CDKN1A, FGF2, FGF9, FGFR1, FGFR3
43positive regulation of MAPK cascadeGO:00434108.8BMP2, DUSP19, FGF9, FGFR1, FGFR3
44chondrocyte differentiationGO:00020628.7BMP2, BMPR1B, FGF9, FGFR1, FGFR3
45axon guidanceGO:00074118.4EXT1, FGF2, FGF9, FGFR1, FGFR3, TGFB2
46positive regulation of cell proliferationGO:00082848.4BCL2, FGF2, FGF9, FGFR1, FGFR3, PTHLH
47negative regulation of cell proliferationGO:00082858.1BCL2, BMP2, CDKN1A, FGF2, FGFR3, PTHLH
48skeletal system developmentGO:00015017.9BMP2, BMPR1B, EXT1, FGFR1, FGFR3, PTHLH
49innate immune responseGO:00450877.9BCL2, CDKN1A, FGF2, FGF9, FGFR1, FGFR3
50positive regulation of gene expressionGO:00106287.9BMP2, E2F1, FGF2, FGF9, TGFB2, VIM

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.7EXT1, EXT2
2glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:005050810.7EXT1, EXT2
3N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.7EXT1, EXT2
4fibroblast growth factor-activated receptor activityGO:000500710.5FGFR1, FGFR3
5receptor signaling protein serine/threonine kinase activityGO:000470210.2BMPR1B, TGFB2
6glycoprotein bindingGO:00019489.9BMPR1B, FGFR1, VIM
7growth factor activityGO:00080838.9BMP2, FGF2, FGF9, TGFB2
8protein heterodimerization activityGO:00469828.4BCL2, BMP2, EXT1, EXT2, TGFB2
9protein homodimerization activityGO:00428038.2BCL2, EXT1, EXT2, FGFR1, S100B, TGFB2

Sources for Osteochondroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet