MCID: OST028
MIFTS: 48

Osteochondroma malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Metabolic diseases, Fetal diseases

Aliases & Classifications for Osteochondroma

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Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 48 27 50
 
Cartilaginous Exostosis 68

Classifications:



Summaries for Osteochondroma

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Wikipedia:71 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to trichorhinophalangeal syndrome, type ii and chondroblastoma. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are TP53 network and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include bone, spinal cord and tongue, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and neoplasm.

Related Diseases for Osteochondroma

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Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1trichorhinophalangeal syndrome, type ii31.8EXT1, EXT2, FGF2, PTHLH
2chondroblastoma29.8S100B, VIM
3hereditary multiple osteochondromas12.4
4dysplasia epiphysealis hemimelica with chondromas and osteochondromas11.8
5metachondromatosis11.4
6carpotarsal osteochondromatosis11.0
7exostoses, multiple, type 110.9
8exostoses, multiple, type 210.9
9potocki-shaffer syndrome10.8
10pacman dysplasia10.7EXT1, EXT2
11heritable pulmonary arterial hypertension10.7EXT1, EXT2
12adenomyoma10.6EXT1, PTHLH
13flnb-related disorders10.6FGFR1, FGFR3
14plasmalogens synthesis deficiency isolated10.6FGFR1, FGFR3
15trigonocephaly 110.5FGFR1, FGFR3
16fryns macrocephaly10.5EXT1, EXT2, PTHLH
17neuropathy, ataxia, and retinitis pigmentosa10.5EXT1, EXT2, PTHLH
18localized chondrosarcoma10.5EXT1, PTHLH
19bladder cancer, somatic10.5FGFR1, FGFR3
20hypotonia10.4S100B, VIM
21anaplastic oligoastrocytoma10.4S100B, VIM
22exstrophy-epispadias complex10.4S100B, VIM
23thanatophoric dysplasia, type ii10.4FGF9, FGFR1, FGFR3
24absence of fingerprints congenital milia10.4S100B, VIM
25lymphangiosarcoma10.4S100B, VIM
26fraxf syndrome10.4S100B, VIM
27inflammatory mfh10.4PTHLH, S100B
28pulmonary venoocclusive disease10.3S100B, VIM
29beare-stevenson cutis gyrata syndrome10.3FGF2, FGFR1, FGFR3
30pediculus humanus capitis infestation10.3S100B, VIM
31solitary osseous plasmacytoma10.3BCL2, CDKN1A
32malignant cystic nephroma10.3S100B, VIM
33lumbar plexus neoplasm10.3S100B, VIM
34retroperitoneal germ cell neoplasm10.3EXT2, PTHLH, VIM
35sm-ahnmd10.3NES, VIM
36cervicitis10.3
37subependymal giant cell astrocytoma10.2S100B, VIM
38mollaret meningitis10.2BCL2, VIM
39intracystic papillary adenoma10.2NES, S100B
40anus leiomyosarcoma10.2PTHLH, S100B, VIM
41adenomyoma of uterine corpus10.2NES, S100B, VIM
42neutrophil immunodeficiency syndrome10.2NES, S100B, VIM
43novak syndrome10.1BCL2, S100B, VIM
44cervix endometrial stromal tumor10.1FGF2, S100B, VIM
45antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.1FGF2, FGF9, FGFR1, FGFR3
46exostosis10.1
47bartholin's gland benign neoplasm10.1S100B, VIM
48chondrosarcoma10.1
49sclerosing liposarcoma10.1S100B, VIM
50malignant adenofibroma10.0S100B, VIM

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms & Phenotypes for Osteochondroma

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GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-588.0BCL2, BMP2, CDKN1A, E2F1, FGFR1

MGI Mouse Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

41 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7BCL2, CDKN1A, E2F1, EXT1, FGF2, FGFR3
2MP:00107717.9BCL2, CDKN1A, E2F1, EXT1, FGF9, FGFR1
3MP:00053797.8BCL2, BMPR1B, CDKN1A, E2F1, FGF9, FGFR1
4MP:00053887.8BCL2, CDKN1A, E2F1, FGF9, FGFR3, PTHLH
5MP:00053697.7BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
6MP:00028737.7BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR1
7MP:00053717.5BMP2, BMPR1B, CDKN1A, EXT1, FGF9, FGFR1
8MP:00053827.1BCL2, BMP2, BMPR1B, CDKN1A, EXT1, FGF9
9MP:00053777.0BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF2
10MP:00053807.0BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
11MP:00053867.0BCL2, CDKN1A, E2F1, EXT1, FGF2, FGF9
12MP:00053916.5BCL2, BMPR1B, CDKN1A, E2F1, EXT1, FGF2
13MP:00053976.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGFR1
14MP:00053816.4BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF9
15MP:00053906.3BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
16MP:00053786.3BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
17MP:00053856.2BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
18MP:00053896.0BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2
19MP:00053765.7BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
20MP:00036315.7BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
21MP:00053845.7BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
22MP:00107685.3BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1

Drugs & Therapeutics for Osteochondroma

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Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etoricoxibapproved, investigationalPhase 492202409-33-4123619
Synonyms:
202409-33-4
5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-2-(6-Methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
5-chloro-6'-Methyl-3-(P-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
5CH
AC1L3WZM
Algix
Arcoxia
C11718
C422649
CHEBI:106706
CHEBI:6339
CHEMBL416146
CID123619
D03710
DB01628
DB07166
ETORICOXIB
 
Etoricoxib
Etoricoxib (USAN/INN)
Etoricoxib [USAN:INN:BAN]
Etoricoxibe
Etoricoxibum
FT-0082494
HMS2090A05
L-791456
L001141
L791456
LS-181802
MK 0663
MK 663
MK-0663
MK-663
Merck Sharp & Dohme brand of etoricoxib
MolPort-003-847-339
NCGC00164578-01
Nucoxia
Tauxib
UNII-WRX4NFY03R
ZINC00579472
2
Tramadolapproved, investigationalPhase 423227203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Crispin
D08623
DB00193
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
 
LS-57116
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol
3Cyclooxygenase InhibitorsPhase 42778
4Peripheral Nervous System AgentsPhase 422776
5Cyclooxygenase 2 InhibitorsPhase 4616
6NarcoticsPhase 43486
7Central Nervous System DepressantsPhase 412806
8Analgesics, OpioidPhase 43091
9Analgesics, Non-NarcoticPhase 46260
10Anti-Inflammatory AgentsPhase 410355
11Anti-Inflammatory Agents, Non-SteroidalPhase 44295
12Antirheumatic AgentsPhase 410627
13AnalgesicsPhase 411287

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus TendonUnknown statusNCT01341509Phase 4
2The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus SurgeryCompletedNCT00733421Phase 4
3Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
4Autologous Stem Cells in Achilles TendinopathyRecruitingNCT02064062Phase 2
5The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
6Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and KneeCompletedNCT01771393
7A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
8Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel PainCompletedNCT02895698
9Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
10The Fibrodysplasia Ossificans Progressiva (FOP) Connection RegistryRecruitingNCT02745158
11Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal SpurRecruitingNCT02934100
12Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
13Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Genetic tests related to Osteochondroma:

id Genetic test Affiliating Genes
1 Osteochondroma27

Anatomical Context for Osteochondroma

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MalaCards organs/tissues related to Osteochondroma:

36
Bone, Spinal cord, Tongue, Appendix, Testes, Liver, Lymph node

Publications for Osteochondroma

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Articles related to Osteochondroma:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. (28082852)
2017
2
Identification of a new mutation in an Iranian family with hereditary multiple osteochondromas. (28053536)
2017
3
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. (27777159)
2017
4
Coracoid-like osteochondroma and painful giant thoracic bursitis. (26677990)
2016
5
Large solitary osteochondroma of the thoracic spine: Case report and review of the literature. (27274405)
2016
6
Osteochondroma. (27712895)
2016
7
NFAT restricts osteochondroma formation from entheseal progenitors. (27158674)
2016
8
Temporomandibular Joint Condylar Osteochondroma: Complete Condylectomy and Joint Replacement Versus Low Condylectomy and Joint Preservation. (26721449)
2016
9
Guideline for the Treatment of Condylar Osteochondroma Combined With Secondary Dentofacial Deformities. (27258707)
2016
10
A giant multi-lobed osteochondroma of the phalanx in an adult: A case report. (28076750)
2016
11
Solitary osteochondroma arising in lumbar spinous process: CaseA report. (27887879)
2016
12
Osteochondroma of the Radial Tuberosity in Child. (27454513)
2016
13
Unilateral mandibular condylar osteochondroma treated with ipsilateral condylectomy and contralateral ramus osteotomy. (27131256)
2016
14
Response to the comment to: "Kulkarni U and Kulkarni A: Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg. 2015 Sep;21(3):e51-4a8^. (27810031)
2016
15
Spinous Process Osteochondroma as a Rare Cause of Lumbar Pain. (27579204)
2016
16
What Lies Beneath: Acropachy Hiding Subungual Osteochondroma. (27658687)
2016
17
Osteochondroma of the lumbar spine. (27318638)
2016
18
Cervical myelopathy due to a solitary osteochondroma: a case report. (27186499)
2016
19
Osteochondroma Presenting as a Calcified Mass in the Sellar Region and Review of the Literature. (27903019)
2016
20
Subungual osteochondroma: Nail sparing excision. (28018078)
2016
21
Extensive Osteochondroma of Talus Presenting as Tarsal Tunnel Syndrome: Report of a case and Literature Review. (27517075)
2016
22
Preoperative and postoperative examination ofA occlusal and maxillofacial changes after osteochondroma extirpation. (26827983)
2016
23
Surgical Treatment of Osteochondroma. (27315315)
2016
24
Comment to: Kulkarni U. Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg 2015;21(Sep (3)):e51-4. (27810030)
2016
25
Talar Osteochondroma Fracture Presenting as Posterior Ankle Impingement. (27269978)
2016
26
Paraarticular osteochondroma of a lumbar facet joint presenting with radiculopathy. (27503186)
2016
27
Endoscopically Assisted Resection of a Rare Mass: Intra-Articular Osteochondroma of Shoulder Originated from Scapula. (26925280)
2016
28
Diode laser ablation of a tracheal osteochondroma in a dog. (27112714)
2016
29
Severe chronic compression of the spinal cord by a C2 laminar osteochondroma in a 71-year-old woman: A case report. (27751750)
2016
30
Osteochondroma Arising from Anterior Inferior Iliac Spine as a Cause of Snapping Hip. (26929811)
2016
31
Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle. (26865041)
2016
32
Repeated otalgia at mealtimes: osteochondroma of the mandibular condyle. (27903414)
2016
33
Osteochondroma of maxillofacial region: Tumor arising from two different developmental bones. (27601834)
2016
34
Giant osteochondroma of the C5 lamina in a young male. (26795102)
2016
35
Osteochondroma of the condyle: case report with 15 years of follow-up. (27156430)
2016
36
Retrocalcaneal Bursitis due to Rare Calcaneal Osteochondroma in Adult Male : Excision and Outcome. (27703931)
2016
37
Identification of a novel frameshift mutation of the EXT2 gene in a family with multiple osteochondroma. (26870176)
2016
38
SOLITARY OSTEOCHONDROMA OF THE DISTAL THIRD METACARPAL BONE IN A TWO-YEAR-OLD WHITE RHINOCEROS (CERATOTHERIUM SIMUM). (28080922)
2016
39
Osteochondroma of Bilateral Mandibular Condyle with Review of Literature. (27656529)
2016
40
Trauma-Induced Resolution of Solitary Osteochondroma of the Distal Femur. (27337667)
2016
41
Osteochondroma Complicated by a Popliteal Vein Aneurysm- A Rare Case Report. (27790548)
2016
42
Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. (27122528)
2016
43
Bilateral Scapulothoracic Osteochondromas in a Patient With Hereditary Multiple Exostosis: A Case Report and Review of the Literature. (27761218)
2016
44
Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas. (26961984)
2016
45
Compressive Myelopathy due to Osteochondroma of the Atlas and Review of the Literature. (26734949)
2016
46
Letter to the Editor: Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. (27574283)
2016
47
Subacromial osteochondroma: A rare cause of impingement syndrome. (25528042)
2015
48
Osteochondroma in long-term survivors of high-risk neuroblastoma. (25728463)
2015
49
Novel Use of Synthetic Acellular Dermal Matrix for Coverage of a Tibial Defect Following Resection of an Osteochondroma: A Case Report. (26353822)
2015
50
Solitary osteochondroma of the trapezoid disguised as a tooth fragment. (26240108)
2015

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7BCL2, CDKN1A
29.6FGF2, FGFR1, FGFR3
39.6FGF2, FGFR1, FGFR3
4
Show member pathways
9.6FGF2, FGF9, FGFR1
5
Show member pathways
9.4FGF2, FGF9, FGFR1, FGFR3
6
Show member pathways
9.4FGF2, FGF9, FGFR1, FGFR3
7
Show member pathways
9.4FGF2, FGF9, FGFR1, FGFR3
8
Show member pathways
9.4FGF2, FGF9, FGFR1, FGFR3
99.4FGF2, FGF9, FGFR1, FGFR3
109.3FGF2, FGFR1, TGFB2
11
Show member pathways
9.2BCL2, BMPR1B, FGFR1, FGFR3
129.2CDKN1A, E2F1, FGFR3
13
Show member pathways
9.1FGF2, FGFR1, FGFR3, TGFB2
148.9CDKN1A, FGF2, FGFR1, TGFB2
15
Show member pathways
8.9CDKN1A, E2F1, FGFR1, FGFR3
168.9FGF2, FGFR1, FGFR3, PTHLH, TGFB2
178.8FGF2, FGF9, FGFR1, FGFR3, TGFB2
188.8BMP2, FGF2, TGFB2
198.6BCL2, CDKN1A, FGF2, FGF9, FGFR1, FGFR3
208.5BCL2, CDKN1A, E2F1, FGF2, FGFR1
218.4BMP2, BMPR1B, FGF2, FGFR1, FGFR3
22
Show member pathways
8.3BMP2, FGF2, FGFR1, FGFR3, TGFB2
238.3BMP2, FGF2, FGFR1, FGFR3, TGFB2
248.3BCL2, BMP2, CDKN1A, E2F1
25
Show member pathways
8.2BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
267.9BCL2, CDKN1A, E2F1, FGFR3, TGFB2, VIM
27
Show member pathways
7.8BMP2, BMPR1B, E2F1, FGF2, TGFB2
287.8BMP2, FGF2, FGFR1, FGFR3, NES, S100B
297.8BCL2, BMP2, CDKN1A, E2F1, TGFB2
30
Show member pathways
7.7BCL2, BMP2, FGF2, FGF9, FGFR1, FGFR3
31
Show member pathways
7.6BCL2, BMP2, BMPR1B, FGF2, FGFR1, FGFR3
32
Show member pathways
7.5BCL2, BMP2, CDKN1A, FGF2, FGFR1, FGFR3
33
Show member pathways
7.2BCL2, BMP2, BMPR1B, CDKN1A, FGF2, FGFR1
346.6BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
35
Show member pathways
6.6BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
36
Show member pathways
6.1BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2

GO Terms for genes affiliated with Osteochondroma

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Cellular components related to Osteochondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5BMP2, FGF2, FGF9, FGFR1, FGFR3, PTHLH

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:003369210.8EXT1, EXT2
2heparan sulfate proteoglycan biosynthetic processGO:001501210.8EXT1, EXT2
3heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:001501410.8EXT1, EXT2
4lung-associated mesenchyme developmentGO:006048410.7FGF9, FGFR1
5positive regulation of phospholipase activityGO:001051810.6FGFR1, FGFR3
6organ inductionGO:000175910.6FGF2, FGFR1
7positive regulation of endothelial cell chemotaxis to fibroblast growth factorGO:200054610.6FGF2, FGFR1
8positive regulation of phospholipase C activityGO:001086310.5FGF2, FGFR1
9embryonic digestive tract developmentGO:004856610.5FGF9, TGFB2
10ossificationGO:000150310.4BCL2, EXT1, EXT2
11generation of neuronsGO:004869910.4FGFR1, TGFB2
12lung developmentGO:003032410.4FGF2, FGF9, FGFR1
13positive regulation of cardiac muscle cell proliferationGO:006004510.3FGF2, FGF9, FGFR1
14salivary gland morphogenesisGO:000743510.2FGFR1, TGFB2
15fibroblast growth factor receptor signaling pathwayGO:000854310.1FGF2, FGF9, FGFR1, FGFR3
16MAPK cascadeGO:000016510.1FGF2, FGF9, FGFR1, FGFR3
17mesenchymal cell differentiationGO:004876210.1BMP2, FGFR1
18peptidyl-tyrosine phosphorylationGO:001810810.1FGF2, FGF9, FGFR1, FGFR3
19positive regulation of cell divisionGO:005178110.1FGF2, FGF9, TGFB2
20phosphatidylinositol phosphorylationGO:004685410.1FGF2, FGF9, FGFR1, FGFR3
21phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.1FGF2, FGF9, FGFR1, FGFR3
22corticotropin hormone secreting cell differentiationGO:006012810.1BMP2, FGF2
23phosphatidylinositol-mediated signalingGO:004801510.1FGF2, FGF9, FGFR1, FGFR3
24eye developmentGO:000165410.1BMPR1B, FGF9, TGFB2
25response to glucocorticoidGO:005138410.0BCL2, CDKN1A, S100B
26positive regulation of cartilage developmentGO:006103610.0BMP2, BMPR1B
27cellular response to hypoxiaGO:007145610.0BCL2, E2F1, S100B
28regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0FGF2, FGF9, FGFR1, FGFR3
29atrioventricular valve morphogenesisGO:00031819.9BMP2, TGFB2
30cardiac epithelial to mesenchymal transitionGO:00603179.9BMP2, TGFB2
31endocardial cushion morphogenesisGO:00032039.9BMP2, TGFB2
32pathway-restricted SMAD protein phosphorylationGO:00603899.9BMP2, TGFB2
33angiogenesisGO:00015259.9FGF2, FGF9, FGFR1, TGFB2
34positive regulation of ossificationGO:00457789.8BMP2, TGFB2
35branching involved in ureteric bud morphogenesisGO:00016589.8BCL2, BMP2, FGF2
36positive regulation of cell differentiationGO:00455979.7BMP2, BMPR1B, FGF2
37positive regulation of osteoblast differentiationGO:00456699.6BMP2, BMPR1B, FGF2
38regulation of cell cycleGO:00517269.4BCL2, CDKN1A, E2F1, FGF2
39thyroid-stimulating hormone-secreting cell differentiationGO:00601299.3BMP2, FGF2
40chondrocyte differentiationGO:00020629.3BMP2, BMPR1B, FGF9, FGFR1, FGFR3
41cell-cell signalingGO:00072679.2BMP2, FGF9, FGFR3, PTHLH, TGFB2
42negative regulation of gene expressionGO:00106299.2BMP2, CDKN1A, FGFR1, TGFB2
43positive regulation of MAPK cascadeGO:00434109.0BMP2, DUSP19, FGF9, FGFR1, FGFR3
44positive regulation of cell proliferationGO:00082848.7BCL2, FGF2, FGF9, FGFR1, FGFR3, PTHLH
45SMAD protein signal transductionGO:00603958.7BMP2, TGFB2, VIM
46negative regulation of cell proliferationGO:00082858.6BCL2, BMP2, CDKN1A, FGF2, PTHLH, TGFB2
47skeletal system developmentGO:00015018.3BMP2, BMPR1B, EXT1, FGFR1, FGFR3, PTHLH
48positive regulation of gene expressionGO:00106288.2BMP2, E2F1, FGF2, FGF9, TGFB2, VIM

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1acetylglucosaminyltransferase activityGO:000837510.8EXT1, EXT2
2glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:005050810.8EXT1, EXT2
3heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.8EXT1, EXT2
4N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.8EXT1, EXT2
5fibroblast growth factor-activated receptor activityGO:000500710.7FGFR1, FGFR3
61-phosphatidylinositol-3-kinase activityGO:001630310.1FGF2, FGF9, FGFR1, FGFR3
7phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.1FGF2, FGF9, FGFR1, FGFR3
8glycoprotein bindingGO:000194810.1BMPR1B, FGFR1, VIM
9protein tyrosine kinase activityGO:00047139.9FGF2, FGF9, FGFR1, FGFR3
10Ras guanyl-nucleotide exchange factor activityGO:00050889.4FGF2, FGF9, FGFR1, FGFR3
11growth factor activityGO:00080839.3BMP2, FGF2, FGF9, TGFB2
12protein homodimerization activityGO:00428039.2BCL2, EXT1, EXT2, FGFR1, S100B, TGFB2
13protein heterodimerization activityGO:00469829.1BCL2, BMP2, EXT1, EXT2, TGFB2

Sources for Osteochondroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet