MCID: OST028
MIFTS: 47

Osteochondroma malady

Categories: Rare diseases, Bone diseases, Genetic diseases, Metabolic diseases, Fetal diseases

Aliases & Classifications for Osteochondroma

Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 50 29 52
Cartilaginous Exostosis 69

Classifications:



Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to trichorhinophalangeal syndrome, type ii and thoracic outlet syndrome. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cellular

Wikipedia : 71 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 trichorhinophalangeal syndrome, type ii 31.9 EXT1 EXT2
2 thoracic outlet syndrome 29.0 BCL2 CDKN1A E2F1
3 hereditary multiple osteochondromas 12.4
4 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 11.8
5 metachondromatosis 11.4
6 hereditary multiple exostoses 11.1
7 carpotarsal osteochondromatosis 11.0
8 exostoses, multiple, type 1 10.9
9 exostoses, multiple, type 2 10.9
10 potocki-shaffer syndrome 10.8
11 erythroderma, lethal congenital 10.3 EXT1 EXT2
12 cervicitis 10.3
13 familial porphyria cutanea tarda 10.3 FGFR1 FGFR3
14 lupus - neurological sequelae 10.3 S100B VIM
15 macrosomia with microphthalmia, lethal 10.2 EXT1 EXT2 PTHLH
16 malignant adult ependymoma 10.2 EXT2 PTHLH VIM
17 apert syndrome 10.2 FGF2 FGFR1 FGFR3
18 benign schwannoma 10.2 S100B VIM
19 hartsfield syndrome 10.2 FGFR1 FGFR3
20 pointer syndrome 10.2 FGFR1 FGFR3
21 central nervous system hemangioma 10.1 NES S100B VIM
22 c-p angle neurinoma 10.1 NES S100B VIM
23 saddan 10.1 FGF9 FGFR1 FGFR3
24 epimetaphyseal dysplasia cataract 10.1 NES S100B VIM
25 jejunal neuroendocrine tumor 10.1 S100B VIM
26 cutaneous leishmaniasis 10.1 FGF2 FGFR1 FGFR3
27 mental retardation, autosomal recessive 40 10.1 EXT1 EXT2 FGF2 PTHLH
28 neutrophil immunodeficiency syndrome 10.1 NES S100B VIM
29 exostosis 10.1
30 his bundle tachycardia 10.1 BCL2 S100B VIM
31 chondrosarcoma 10.1
32 scaphocephaly, maxillary retrusion, and mental retardation 10.1 FGF2 FGF9 FGFR1 FGFR3
33 cecum adenoma 10.1 BCL2 S100B VIM
34 grade iii astrocytoma 10.0 FGF2 FGFR1 NES S100B
35 thrombosis 10.0
36 myoma 10.0 S100B VIM
37 cervical cancer, somatic 10.0 EXT1 FGF2 FGF9 FGFR1 FGFR3
38 juvenile astrocytoma 10.0 FGFR1 FGFR3 NES S100B VIM
39 ischemic bone disease 10.0 BMP2 EXT1 EXT2
40 bursitis 10.0
41 muscular dystrophy-dystroglycanopathy 9.9 BMP2 BMPR1B PTHLH
42 tarsal-carpal coalition syndrome 9.9 BMP2 BMPR1B FGF9
43 binocular vision disease 9.9 BMP2 PTHLH
44 multiple synostoses syndrome 9.9 BMP2 BMPR1B FGF9
45 13q12.3 microdeletion syndrome 9.9 BCL2 CDKN1A FGFR3 PTHLH VIM
46 dysplasia epiphysealis hemimelica 9.9
47 synovial chondromatosis 9.9
48 chondroma 9.8
49 fibrodysplasia ossificans progressiva 9.8
50 enchondroma 9.8

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.7 E2F1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.7 E2F1 BMP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.7 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 BMP2 CDKN1A E2F1 FGFR1 BCL2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.7 CDKN1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.7 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.7 BCL2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.7 E2F1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.7 E2F1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.7 FGFR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.7 CDKN1A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.7 FGFR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.7 E2F1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.7 BMP2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.7 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.7 BCL2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.7 BCL2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.7 CDKN1A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.7 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

44 (show all 22)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
2 behavior/neurological MP:0005386 10.35 E2F1 EXT1 FGF2 FGF9 FGFR1 FGFR3
3 cardiovascular system MP:0005385 10.3 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
4 mortality/aging MP:0010768 10.3 FGF2 FGF9 FGFR1 FGFR3 PTHLH TGFB2
5 growth/size/body region MP:0005378 10.29 BCL2 BMP2 BMPR1B CDKN1A E2F1 EXT1
6 homeostasis/metabolism MP:0005376 10.29 VIM BCL2 BMP2 CDKN1A E2F1 FGF2
7 craniofacial MP:0005382 10.28 BCL2 BMP2 BMPR1B CDKN1A EXT1 FGF9
8 digestive/alimentary MP:0005381 10.27 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF9
9 hearing/vestibular/ear MP:0005377 10.24 BCL2 BMP2 CDKN1A E2F1 EXT1 FGF2
10 embryo MP:0005380 10.22 BMP2 BMPR1B CDKN1A E2F1 EXT1 EXT2
11 hematopoietic system MP:0005397 10.22 BCL2 BMP2 CDKN1A E2F1 FGF2 FGFR1
12 endocrine/exocrine gland MP:0005379 10.16 BCL2 BMPR1B CDKN1A E2F1 FGF9 FGFR1
13 integument MP:0010771 10.15 BCL2 CDKN1A E2F1 EXT1 FGF9 FGFR1
14 nervous system MP:0003631 10.15 TGFB2 VIM BCL2 BMP2 BMPR1B CDKN1A
15 limbs/digits/tail MP:0005371 10.13 BMP2 BMPR1B CDKN1A EXT1 FGF9 FGFR1
16 muscle MP:0005369 10.03 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
17 reproductive system MP:0005389 10.03 FGF9 FGFR1 FGFR3 PTHLH TGFB2 VIM
18 normal MP:0002873 9.92 FGFR3 S100B BMP2 BMPR1B E2F1 EXT1
19 neoplasm MP:0002006 9.88 BCL2 CDKN1A E2F1 EXT1 FGF2 FGFR3
20 respiratory system MP:0005388 9.76 BCL2 CDKN1A E2F1 FGF9 FGFR3 PTHLH
21 skeleton MP:0005390 9.73 BMP2 BMPR1B CDKN1A E2F1 EXT1 EXT2
22 vision/eye MP:0005391 9.4 BCL2 BMPR1B CDKN1A E2F1 EXT1 FGF2

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3 Analgesics Phase 4
4 Narcotics Phase 4
5 Cyclooxygenase 2 Inhibitors Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics, Opioid Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Antirheumatic Agents Phase 4
13 Central Nervous System Depressants Phase 4

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
5 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
6 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
7 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393
8 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
9 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
10 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
11 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
12 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
13 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
14 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Genetic tests related to Osteochondroma:

id Genetic test Affiliating Genes
1 Osteochondroma 29

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

39
Bone, Spinal Cord, Testes, Liver, Tongue, Appendix, Uterus

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 697)
id Title Authors Year
1
Identification of a novel mutation in the EXT1 gene from a patient with multiple osteochondromas by exome sequencing. ( 28035357 )
2017
2
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. ( 27777159 )
2017
3
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. ( 28082852 )
2017
4
Identification of a new mutation in an Iranian family with hereditary multiple osteochondromas. ( 28053536 )
2017
5
Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle. ( 26865041 )
2016
6
Coracoid-like osteochondroma and painful giant thoracic bursitis. ( 26677990 )
2016
7
NFAT restricts osteochondroma formation from entheseal progenitors. ( 27158674 )
2016
8
Subungual osteochondroma: Nail sparing excision. ( 28018078 )
2016
9
Response to the comment to: "Kulkarni U and Kulkarni A: Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg. 2015 Sep;21(3):e51-4a8^. ( 27810031 )
2016
10
Compressive Myelopathy due to Osteochondroma of the Atlas and Review of the Literature. ( 26734949 )
2016
11
Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas. ( 26961984 )
2016
12
Diode laser ablation of a tracheal osteochondroma in a dog. ( 27112714 )
2016
13
Trauma-Induced Resolution of Solitary Osteochondroma of the Distal Femur. ( 27337667 )
2016
14
Osteochondroma Complicated by a Popliteal Vein Aneurysm- A Rare Case Report. ( 27790548 )
2016
15
Osteochondroma of Bilateral Mandibular Condyle with Review of Literature. ( 27656529 )
2016
16
Novel mutation of EXT2 identified in a large family with multiple osteochondromas. ( 27748933 )
2016
17
Osteochondroma of the condyle: case report with 15 years of follow-up. ( 27156430 )
2016
18
Giant osteochondroma of the C5 lamina in a young male. ( 26795102 )
2016
19
Osteochondroma of maxillofacial region: Tumor arising from two different developmental bones. ( 27601834 )
2016
20
Guideline for the Treatment of Condylar Osteochondroma Combined With Secondary Dentofacial Deformities. ( 27258707 )
2016
21
Osteochondroma Arising from Anterior Inferior Iliac Spine as a Cause of Snapping Hip. ( 26929811 )
2016
22
Osteochondroma of the lumbar spine. ( 27318638 )
2016
23
What Lies Beneath: Acropachy Hiding Subungual Osteochondroma. ( 27658687 )
2016
24
Identification of a novel frameshift mutation of the EXT2 gene in a family with multiple osteochondroma. ( 26870176 )
2016
25
Severe chronic compression of the spinal cord by a C2 laminar osteochondroma in a 71-year-old woman: A case report. ( 27751750 )
2016
26
Spinous Process Osteochondroma as a Rare Cause of Lumbar Pain. ( 27579204 )
2016
27
Solitary osteochondroma arising in lumbar spinous process: CaseA report. ( 27887879 )
2016
28
Comment to: Kulkarni U. Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg 2015;21(Sep (3)):e51-4. ( 27810030 )
2016
29
Endoscopically Assisted Resection of a Rare Mass: Intra-Articular Osteochondroma of Shoulder Originated from Scapula. ( 26925280 )
2016
30
Large solitary osteochondroma of the thoracic spine: Case report and review of the literature. ( 27274405 )
2016
31
Unilateral mandibular condylar osteochondroma treated with ipsilateral condylectomy and contralateral ramus osteotomy. ( 27131256 )
2016
32
Temporomandibular Joint Condylar Osteochondroma: Complete Condylectomy and Joint Replacement Versus Low Condylectomy and Joint Preservation. ( 26721449 )
2016
33
Osteochondroma. ( 27712895 )
2016
34
Repeated otalgia at mealtimes: osteochondroma of the mandibular condyle. ( 27903414 )
2016
35
Osteochondroma of the Radial Tuberosity in Child. ( 27454513 )
2016
36
Preoperative and postoperative examination ofA occlusal and maxillofacial changes after osteochondroma extirpation. ( 26827983 )
2016
37
Surgical Treatment of Osteochondroma. ( 27315315 )
2016
38
Osteochondroma Presenting as a Calcified Mass in the Sellar Region and Review of the Literature. ( 27903019 )
2016
39
Letter to the Editor: Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. ( 27574283 )
2016
40
Retrocalcaneal Bursitis due to Rare Calcaneal Osteochondroma in Adult Male : Excision and Outcome. ( 27703931 )
2016
41
Paraarticular osteochondroma of a lumbar facet joint presenting with radiculopathy. ( 27503186 )
2016
42
Talar Osteochondroma Fracture Presenting as Posterior Ankle Impingement. ( 27269978 )
2016
43
Extensive Osteochondroma of Talus Presenting as Tarsal Tunnel Syndrome: Report of a case and Literature Review. ( 27517075 )
2016
44
Cervical myelopathy due to a solitary osteochondroma: a case report. ( 27186499 )
2016
45
Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. ( 27122528 )
2016
46
A giant multi-lobed osteochondroma of the phalanx in an adult: A case report. ( 28076750 )
2016
47
Bilateral Scapulothoracic Osteochondromas in a Patient With Hereditary Multiple Exostosis: A Case Report and Review of the Literature. ( 27761218 )
2016
48
SOLITARY OSTEOCHONDROMA OF THE DISTAL THIRD METACARPAL BONE IN A TWO-YEAR-OLD WHITE RHINOCEROS (CERATOTHERIUM SIMUM). ( 28080922 )
2016
49
Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat? ( 26239617 )
2015
50
Endoscopic Excision of Osteochondroma of the Mandibular Angle. ( 26430650 )
2015

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 39)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
2
Show member pathways
13.66 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
3
Show member pathways
13.48 BCL2 BMP2 CDKN1A FGF2 FGF9 FGFR1
4
Show member pathways
13.3 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
5
Show member pathways
13.27 BCL2 BMP2 BMPR1B CDKN1A FGF2 FGFR1
6
Show member pathways
13.21 BCL2 BMP2 BMPR1B FGF2 FGFR1 FGFR3
7
Show member pathways
12.81 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
8
Show member pathways
12.66 CDKN1A FGF2 FGF9 FGFR1 FGFR3
9 12.64 FGF2 FGF9 FGFR1 FGFR3 TGFB2
10
Show member pathways
12.61 BMP2 FGF2 FGFR1 FGFR3 TGFB2
11
Show member pathways
12.46 EXT1 EXT2 FGFR1 PTHLH
12
Show member pathways
12.39 FGF2 FGF9 FGFR1 FGFR3
13
Show member pathways
12.38 BCL2 BMPR1B FGFR1 FGFR3
14
Show member pathways
12.35 FGF2 FGF9 FGFR1 FGFR3
15
Show member pathways
12.34 FGF2 FGF9 FGFR1 FGFR3
16
Show member pathways
12.34 BMP2 BMPR1B E2F1 FGF2 TGFB2
17 12.33 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
18 12.24 CDKN1A FGF2 FGFR1 TGFB2
19
Show member pathways
12.21 FGF2 FGF9 FGFR1 FGFR3
20 12.21 BCL2 CDKN1A E2F1 FGFR3 TGFB2 VIM
21 12.21 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
22
Show member pathways
12.08 CDKN1A E2F1 FGFR1 FGFR3
23
Show member pathways
12.05 FGF2 FGF9 FGFR1 FGFR3
24 11.98 BMPR1B FGF2 FGFR1 FGFR3
25 11.86 FGF2 FGFR1 FGFR3
26 11.84 BCL2 CDKN1A FGF2 VIM
27 11.83 BMP2 FGF2 TGFB2
28
Show member pathways
11.8 FGF2 FGF9 FGFR1
29 11.78 BCL2 BMP2 CDKN1A E2F1
30 11.76 BMP2 BMPR1B TGFB2
31 11.69 CDKN1A E2F1 FGFR3
32 11.67 FGF2 FGFR1 FGFR3 TGFB2
33 11.6 BMP2 FGF2 FGFR1 FGFR3 TGFB2
34
Show member pathways
11.54 FGF2 FGF9 FGFR3
35 11.5 BCL2 BMP2 CDKN1A E2F1 TGFB2
36 11.44 FGF2 FGFR1 TGFB2
37 11.4 BCL2 CDKN1A E2F1
38 11.37 FGF2 FGFR1 FGFR3 PTHLH TGFB2
39 11.07 BMP2 FGF2 FGFR1 FGFR3 NES S100B

GO Terms for Osteochondroma

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 46)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 FGF2 FGF9 FGFR1 FGFR3
2 positive regulation of gene expression GO:0010628 9.96 BMP2 E2F1 FGF9 TGFB2 VIM
3 angiogenesis GO:0001525 9.93 FGF2 FGF9 FGFR1 TGFB2
4 cell-cell signaling GO:0007267 9.93 BMP2 FGF9 FGFR3 PTHLH TGFB2
5 negative regulation of gene expression GO:0010629 9.9 BMP2 CDKN1A FGFR1 TGFB2
6 peptidyl-tyrosine phosphorylation GO:0018108 9.89 FGF2 FGF9 FGFR1 FGFR3
7 male gonad development GO:0008584 9.87 BCL2 FGF9 TGFB2
8 cellular response to hypoxia GO:0071456 9.85 BCL2 E2F1 S100B
9 BMP signaling pathway GO:0030509 9.84 BMP2 BMPR1B TGFB2
10 response to glucocorticoid GO:0051384 9.82 BCL2 CDKN1A S100B
11 phosphatidylinositol-mediated signaling GO:0048015 9.81 FGF2 FGF9 FGFR1 FGFR3
12 SMAD protein signal transduction GO:0060395 9.79 BMP2 TGFB2 VIM
13 embryonic limb morphogenesis GO:0030326 9.78 FGF9 FGFR1 TGFB2
14 phosphatidylinositol phosphorylation GO:0046854 9.78 FGF2 FGF9 FGFR1 FGFR3
15 positive regulation of cell division GO:0051781 9.76 FGF2 FGF9 TGFB2
16 ossification GO:0001503 9.76 BCL2 BMP2 EXT1 EXT2
17 positive regulation of cell proliferation GO:0008284 9.76 BCL2 FGF2 FGF9 FGFR1 FGFR3 PTHLH
18 branching involved in ureteric bud morphogenesis GO:0001658 9.74 BCL2 BMP2 FGF2
19 fibroblast growth factor receptor signaling pathway GO:0008543 9.71 FGF2 FGF9 FGFR1 FGFR3
20 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.7 EXT1 EXT2
21 embryonic digestive tract development GO:0048566 9.7 FGF9 TGFB2
22 eye development GO:0001654 9.7 BMPR1B FGF9 TGFB2
23 positive regulation of cartilage development GO:0061036 9.69 BMP2 BMPR1B
24 endocardial cushion morphogenesis GO:0003203 9.68 BMP2 TGFB2
25 positive regulation of ossification GO:0045778 9.68 BMP2 TGFB2
26 pathway-restricted SMAD protein phosphorylation GO:0060389 9.68 BMP2 TGFB2
27 cardiac epithelial to mesenchymal transition GO:0060317 9.67 BMP2 TGFB2
28 generation of neurons GO:0048699 9.67 FGFR1 TGFB2
29 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.67 FGF2 FGF9 FGFR1 FGFR3
30 atrioventricular valve morphogenesis GO:0003181 9.66 BMP2 TGFB2
31 salivary gland morphogenesis GO:0007435 9.65 FGFR1 TGFB2
32 lung-associated mesenchyme development GO:0060484 9.65 FGF9 FGFR1
33 mesenchymal cell differentiation GO:0048762 9.65 BMP2 FGFR1
34 positive regulation of MAPK cascade GO:0043410 9.65 BMP2 DUSP19 FGF9 FGFR1 FGFR3
35 stem cell proliferation GO:0072089 9.64 FGF2 NES
36 positive regulation of phospholipase C activity GO:0010863 9.63 FGF2 FGFR1
37 positive regulation of phospholipase activity GO:0010518 9.62 FGFR1 FGFR3
38 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.62 FGF2 FGF9 FGFR1 FGFR3
39 positive regulation of cardiac muscle cell proliferation GO:0060045 9.61 FGF2 FGF9 FGFR1
40 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.58 FGF2 FGFR1
41 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.55 EXT1 EXT2
42 cellular polysaccharide biosynthetic process GO:0033692 9.49 EXT1 EXT2
43 chondrocyte differentiation GO:0002062 9.35 BMP2 BMPR1B FGF9 FGFR1 FGFR3
44 skeletal system development GO:0001501 9.17 BMP2 BMPR1B EXT1 FGFR1 FGFR3 PTHLH
45 protein phosphorylation GO:0006468 10.09 BMP2 BMPR1B FGFR1 FGFR3 TGFB2
46 negative regulation of cell proliferation GO:0008285 10.01 BCL2 BMP2 CDKN1A PTHLH TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.97 BCL2 EXT1 EXT2 FGFR1 S100B TGFB2
2 protein heterodimerization activity GO:0046982 9.91 BCL2 BMP2 EXT1 EXT2 TGFB2
3 protein tyrosine kinase activity GO:0004713 9.76 FGF2 FGF9 FGFR1 FGFR3
4 growth factor activity GO:0008083 9.73 BMP2 FGF2 FGF9 TGFB2
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.62 FGF2 FGF9 FGFR1 FGFR3
6 fibroblast growth factor-activated receptor activity GO:0005007 9.48 FGFR1 FGFR3
7 receptor-receptor interaction GO:0090722 9.4 FGF2 FGFR1
8 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.37 EXT1 EXT2
9 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.26 EXT1 EXT2
10 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF2 FGF9 FGFR1 FGFR3
11 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.16 EXT1 EXT2
12 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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