MCID: OST028
MIFTS: 47

Osteochondroma malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Metabolic diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Osteochondroma

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Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 45 47
 
Cartilaginous Exostosis 65

Classifications:



External Ids:

UMLS65 C0029423

Summaries for Osteochondroma

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Wikipedia:68 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to chondroma and trichorhinophalangeal syndrome, type ii. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are Signaling events mediated by the Hedgehog family and Bladder cancer. Affiliated tissues include bone, brain and t cells, and related mouse phenotypes are respiratory system and embryo.

Related Diseases for Osteochondroma

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Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1chondroma30.8EXT1, PTHLH
2trichorhinophalangeal syndrome, type ii30.6EXT1, EXT2, PTHLH
3hereditary multiple osteochondromas12.4
4carpotarsal osteochondromatosis11.1
5hereditary multiple exostoses10.7
6metachondromatosis10.6
7dysplastic cortical hyperostosis10.6EXT1, EXT2
8hereditary paraganglioma-pheochromocytoma syndromes10.5EXT1, EXT2
9myxoid chondrosarcoma10.5EXT1, PTHLH
10vulvar nodular hidradenoma10.5EXT1, EXT2
11anxiety disorder10.5EXT1, EXT2
12cervicitis10.4
13irritant dermatitis10.3FGFR3, PTHLH
14eosinophilic pneumonia10.3EXT2, PTHLH
15agraphia10.3EXT1, EXT2, PTHLH
16hydranencephaly10.3EXT1, EXT2, PTHLH
17extratemporal epilepsy10.3FGFR3, PTHLH
18exostosis10.2
19epidermolysis bullosa, pretibial10.2FGFR3, PTHLH
20chondrosarcoma10.2
21bone osteosarcoma10.1PTHLH, TGFB2
22skeleto cardiac syndrome with thrombocytopenia10.1FGFR3, PTHLH
23clove syndrome, somatic10.1FGFR3, TGFB2
24bursitis10.0
25exostoses, multiple, type 110.0
26exostoses, multiple, type 210.0
27dysplasia epiphysealis hemimelica10.0
28synovial chondromatosis10.0
29thanatophoric dysplasia, type ii10.0FGF9, FGFR3
30albright's hereditary osteodystrophy10.0BMPR1B, FGFR3
31acromesomelic dysplasia, demirhan type10.0BMP2, BMPR1B
32fibrodysplasia ossificans progressiva9.9
33enchondroma9.9
34potocki-shaffer syndrome9.9
35pseudoarthrosis9.9
36aneurysm9.9
37cone dystrophy9.8BMPR1B, FGF9
38bone development disease9.8BMP2, EXT1, EXT2
39muenke syndrome9.8
40hematopoietic stem cell transplantation9.8
41sleep apnea9.8
42osteoblastoma9.8
43sarcoma9.8
44vertebral artery occlusion9.8
45quadriplegia9.8
46ankylosis9.8
47brown-sequard syndrome9.8
48neuropathy9.8
49periostitis9.8
50dysphagia9.8

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms for Osteochondroma

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Drugs & Therapeutics for Osteochondroma

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Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etoricoxibapproved, investigationalPhase 489202409-33-4123619
Synonyms:
202409-33-4
5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-2-(6-Methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
5-chloro-6'-Methyl-3-(P-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
5CH
AC1L3WZM
Algix
Arcoxia
C11718
C422649
CHEBI:106706
CHEBI:6339
CHEMBL416146
CID123619
D03710
DB01628
DB07166
ETORICOXIB
 
Etoricoxib
Etoricoxib (USAN/INN)
Etoricoxib [USAN:INN:BAN]
Etoricoxibe
Etoricoxibum
FT-0082494
HMS2090A05
L-791456
L001141
L791456
LS-181802
MK 0663
MK 663
MK-0663
MK-663
Merck Sharp & Dohme brand of etoricoxib
MolPort-003-847-339
NCGC00164578-01
Nucoxia
Tauxib
UNII-WRX4NFY03R
ZINC00579472
2
Tramadolapproved, investigationalPhase 421427203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Conzip
Crispin
D08623
DB00193
Durela
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
LS-57116
 
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
Ryzolt
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol Hydrochloride
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol
3Cyclooxygenase InhibitorsPhase 42225
4Peripheral Nervous System AgentsPhase 418510
5Cyclooxygenase 2 InhibitorsPhase 4538
6Antirheumatic AgentsPhase 48496
7Analgesics, Non-NarcoticPhase 45184
8Anti-Inflammatory AgentsPhase 48478
9Anti-Inflammatory Agents, Non-SteroidalPhase 43549
10AnalgesicsPhase 49358

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus SurgeryCompletedNCT00733421Phase 4
2Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
3A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus TendonRecruitingNCT01341509Phase 4
4Autologous Stem Cells in Achilles TendinopathyRecruitingNCT02064062Phase 2
5The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
6Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and KneeCompletedNCT01771393
7A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
8Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
9The Fibrodysplasia Ossificans Progressiva (FOP) Connection RegistryRecruitingNCT02745158
10Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
11Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Anatomical Context for Osteochondroma

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MalaCards organs/tissues related to Osteochondroma:

33
Bone, Brain, T cells, Prostate, Spinal cord, Endothelial, Lung

Animal Models for Osteochondroma or affiliated genes

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MGI Mouse Phenotypes related to Osteochondroma:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5E2F1, FGF9, FGFR3, PTHLH, TGFB2
2MP:00053808.0BMP2, BMPR1B, E2F1, EXT1, EXT2, TGFB2
3MP:00053917.8BMPR1B, E2F1, EXT1, FGF9, FGFR3, PTHLH
4MP:00053717.7BMP2, BMPR1B, EXT1, FGF9, FGFR3, PTHLH
5MP:00053827.4BMP2, BMPR1B, EXT1, FGF9, FGFR3, PTHLH
6MP:00036317.3BMP2, BMPR1B, E2F1, EXT1, FGFR3, PTHLH
7MP:00053897.3BMP2, BMPR1B, E2F1, FGF9, FGFR3, PTHLH
8MP:00053817.3BMP2, E2F1, EXT1, FGF9, FGFR3, PTHLH
9MP:00053777.1BMP2, E2F1, EXT1, FGF9, FGFR3, TGFB2
10MP:00053846.9BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR3
11MP:00053786.6BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR3
12MP:00107686.4BMP2, BMPR1B, E2F1, EXT1, EXT2, FGF9
13MP:00053906.4BMP2, BMPR1B, E2F1, EXT1, EXT2, FGF9

Publications for Osteochondroma

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Articles related to Osteochondroma:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
Preoperative and postoperative examination ofA occlusal and maxillofacial changes after osteochondroma extirpation. (26827983)
2016
2
Coracoid-like osteochondroma and painful giant thoracic bursitis. (26677990)
2016
3
Subacromial osteochondroma: A rare cause of impingement syndrome. (25528042)
2015
4
Osteochondroma in long-term survivors of high-risk neuroblastoma. (25728463)
2015
5
Osteochondroma of the glenoid fossa-report of two cases with sudden onset of symptoms. (25277805)
2014
6
Low condylectomy and orthognathic surgery to treat mandibular condylar osteochondroma: a retrospective review of 37 cases. (24997022)
2014
7
Osteochondroma of the palate: An interesting and an unusual case presentation. (25328318)
2014
8
Synovial chondromatosis of pes anserine bursa secondary to osteochondroma. (25102510)
2014
9
Letter regarding "Effect of osteochondroma location on forearm deformity in patients with multiple hereditary osteochondromatosis". (23790427)
2013
10
Transformation of solitary osteochondroma to dedifferentiated chondrosarcoma arising in the distal radius: a case report. (23007379)
2013
11
Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas. (23412166)
2013
12
Osteochondroma of mandibular condyle: A clinic-radiographic correlation. (24082753)
2013
13
Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas. (24009674)
2013
14
Osteochondroma of the temporomandibular joint: report of 2 cases emphasizing the importance of personalizing the surgical treatment. (22669156)
2012
15
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (22246151)
2012
16
Isolated osteochondroma of the femoral neck presenting as hip and leg pain. A case study. (22619103)
2012
17
Malignant degeneration of a lumbar osteochondroma into a chondrosarcoma which mimicked a large retropertioneal mass. (22526879)
2012
18
A synovial osteochondroma replacing the anterior cruciate ligament at the intercondylar notch. (21323282)
2011
19
Computer-assisted surgical planning and simulation for condylar reconstruction in patients with osteochondroma. (20427106)
2011
20
Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. (21506131)
2011
21
Scapular osteochondroma treated with arthroscopic excision using prone positioning. (20396684)
2010
22
Cervical spine osteochondroma: rare presentation of a common lesion. (21109061)
2010
23
Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. (20012156)
2010
24
A rare anterior sacral osteochondroma presenting as sciatica in an adult: a case report and review of the literature. (20421072)
2010
25
Resected osteochondroma of the rib in an elderly patient. (21069500)
2010
26
A multilobed osteochondroma of the hamate: case report. (19695798)
2009
27
Osteochondroma of the mandibular condyle: Resection and reconstruction using vertical sliding osteotomy of the mandibular ramus. (19333189)
2009
28
Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. (18196252)
2008
29
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. (17301954)
2007
30
Phalangeal osteochondroma. (17323627)
2007
31
Discomfort during sexual intercourse secondary to osteochondroma: a report of two cases. (17588798)
2007
32
Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. (17226760)
2007
33
Osteochondroma of the skull base. (17599588)
2007
34
An optimized DHPLC protocol for molecular testing of the EXT1 and EXT2 genes in hereditary multiple osteochondromas. (16283885)
2005
35
A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica? (14564279)
2003
36
Extraskeletal osteochondroma of the buttock. (12589103)
2003
37
Condylar osteochondroma with complete hearing loss: report of a case. (12524621)
2003
38
Arterial compromise caused by lower limb osteochondroma. (12799727)
2003
39
Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage. (12472121)
2002
40
Osteochondroma of the posterior nasal septum managed by endoscopic transnasal transseptal approach. (12487678)
2002
41
Two cases of osteochondroma recurrence after surgical resection. (11198832)
2001
42
Osteochondroma of the C5 lamina with cord compression: case report and review of the literature. (10806510)
2000
43
Cervical myelopathy due to an osteochondroma in a 73-year-old female. The oldest case in the literature. (10983260)
2000
44
Osteochondroma of the tracheal wall in a Fischer's lovebird (Agapornis fischeri, Reichenow 1887). (10216774)
1999
45
Scaphoid osteochondroma. (9457602)
1997
46
Dysplasia epiphysealis hemimelica. Upper limb involvement with associated osteochondroma. (7924021)
1994
47
Cervical osteochondroma (C2 level) with vertebral artery occlusion and second cervical nerve root irritation. (2718087)
1989
48
Osteochondroma with thoracic cord compression in hereditary multiple exostoses: a case report. (312508)
1979
49
Osteochondroma of the cervical spine: a cause of transient quadriplegia. (460559)
1979
50
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. (5803809)
1969

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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GO Terms for genes affiliated with Osteochondroma

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Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan biosynthetic processGO:000602410.4EXT1, EXT2
2protein glycosylationGO:000648610.2EXT1, EXT2
3cartilage condensationGO:000150210.2BMPR1B, TGFB2
4signal transduction by protein phosphorylationGO:002301410.0BMPR1B, TGFB2
5phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.0FGF9, FGFR3
6embryonic digestive tract developmentGO:004856610.0FGF9, TGFB2
7positive regulation of cell divisionGO:005178110.0FGF9, TGFB2
8positive regulation of cartilage developmentGO:00610369.9BMP2, BMPR1B
9activation of protein kinase activityGO:00321479.9DUSP19, TGFB2
10cardiac epithelial to mesenchymal transitionGO:00603179.7BMP2, TGFB2
11pathway-restricted SMAD protein phosphorylationGO:00603899.7BMP2, TGFB2
12embryo developmentGO:00097909.6BMP2, TGFB2
13positive regulation of cell differentiationGO:00455979.6BMP2, BMPR1B
14eye developmentGO:00016549.6BMPR1B, FGF9, TGFB2
15endocardial cushion morphogenesisGO:00032039.5BMP2, TGFB2
16positive regulation of ossificationGO:00457789.5BMP2, TGFB2
17epithelial to mesenchymal transitionGO:00018379.5BMP2, TGFB2
18SMAD protein signal transductionGO:00603959.5BMP2, TGFB2
19chondrocyte differentiationGO:00020629.4BMP2, BMPR1B, FGF9
20positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.4BMP2, TGFB2
21growthGO:00400079.4BMP2, TGFB2
22bone mineralizationGO:00302829.2BMP2, FGFR3
23positive regulation of MAPK cascadeGO:00434109.2BMP2, FGF9, FGFR3
24cell-cell signalingGO:00072678.9BMP2, PTHLH, TGFB2
25positive regulation of gene expressionGO:00106288.6BMP2, E2F1, FGF9
26positive regulation of cell proliferationGO:00082848.5FGF9, FGFR3, PTHLH, TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.3EXT1, EXT2
2heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.3EXT1, EXT2
3acetylglucosaminyltransferase activityGO:000837510.2EXT1, EXT2
4glucuronosyltransferase activityGO:00150209.6EXT1, EXT2
5SMAD bindingGO:00463329.3BMP2, BMPR1B

Sources for Osteochondroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet