MCID: OST028
MIFTS: 49

Osteochondroma malady

Bone category

Summaries for Osteochondroma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Osteochondroma is a type of benign tumor that consists of cartilage and bone. It is a benign... more...

MalaCards: Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and hereditary multiple exostoses. An important gene associated with Osteochondroma is EXT2 (exostosin glycosyltransferase 2), and among its related pathways are CREB Pathway and TGF-Beta Pathway. The compounds forskolin and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and spinal cord, and related mouse phenotypes are limbs/digits/tail and homeostasis/metabolism.

Aliases & Classifications for Osteochondroma

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

osteochondroma 43 45
cartilaginous exostosis 61


Related Diseases for Osteochondroma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary multiple osteochondromas30.8EXT2, EXT1
2hereditary multiple exostoses30.7POMGNT2, EXT2, EXT1
3fibrodysplasia ossificans progressiva30.1ACVR1, BMP2
4muenke syndrome30.0FGFR1, FGFR3
5ankylosis29.8BMP2
6synostosis29.8FGFR1, FGFR3
7adenocarcinoma29.8PTHLH, BMP2, E2F1, TGFB2, NES, FGFR1
8dysplasia epiphysealis hemimelica10.3
9metachondromatosis10.3
10enchondroma10.2
11vertebral artery occlusion10.1
12brown syndrome10.1
13pseudoarthrosis10.0
14osteoblastoma10.0
15quadriplegia10.0
16brown-sequard syndrome10.0
17carpotarsal osteochondromatosis10.0
18synovial chondromatosis10.0
19dysphagia10.0
20sleep apnea10.0
21venous thrombosis10.0
22hematopoietic stem cell transplantation10.0
23multiple myeloma10.0FGFR3
24thanatophoric dysplasia10.0FGFR3
25hyperparathyroidism10.0PTHLH
26leiomyoma10.0NES
27down syndrome10.0FGFR3
28primary pulmonary hypertension10.0BMP2
29hydrocephalus10.0NES
30ladd syndrome10.0FGFR3
31exostosis10.0EXT1, EXT2
32osteoglophonic dysplasia10.0FGFR1
33cervical cancer10.0DUSP19, FGFR3
34autosomal dominant disease10.0EXT2, EXT1
35achondroplasia10.0FGF9, FGFR3
36hypercalcemia10.0PTHLH
37prolactinoma10.0E2F1, PTHLH
38hypochondroplasia10.0FGFR1, FGFR3
39myelofibrosis10.0FGF2
40ollier disease10.0EXT1, PTHLH, EXT2
41meningioma10.0POMGNT2
42osteochondrodysplasia10.0FGFR3, PTHLH
43fgfr-related craniosynostosis syndromes10.0FGFR3, FGFR1
44jackson-weiss syndrome10.0FGFR3, FGFR1
45short stature10.0FGFR3, PTPN11
46congenital heart defect10.0PTPN11
47seborrheic keratosis10.0TGFB2, FGFR3
48teratoma10.0FGFR1, NES
49pheochromocytoma10.0DUSP19, POMGNT2
50ovarian cancer10.0BMP2, E2F1, TGFB2

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Clinical Features for Osteochondroma

Drugs & Therapeutics for Osteochondroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteochondroma

Drug clinical trials:

Search ClinicalTrials for Osteochondroma

Search NIH Clinical Center for Osteochondroma

Search CenterWatch for Osteochondroma

Genetic Tests for Osteochondroma

Anatomical Context for Osteochondroma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Osteochondroma:

33
Liver, Tongue, Spinal cord, Lymph node, Uterus, Bone marrow, Breast, Appendix

Animal Models for Osteochondroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Osteochondroma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.3EXT1, BMPR1B, FGF9, PTPN11
2MP:00053769.2PTPN11, ACVR1, FGF9, FGFR3
3MP:00107719.0E2F1, FGFR1, FGF9
4MP:00053799.0PTPN11, FGFR1, E2F1
5MP:00053809.0BMPR1B, BMP2, NES, ACVR1, TGFB2
6MP:00036318.3E2F1, BMPR1B, BMP2, ACVR1, PTPN11
7MP:00053778.2EXT1, E2F1, BMP2, FGFR3, FGF9, ACVR1
8MP:00053908.1TGFB2, EXT2, BMP2, FGFR1, FGFR3, FGF9
9MP:00020068.1EXT1, E2F1, FGFR3, FGF2, ACVR1, PTPN11
10MP:00053887.9E2F1, FGFR3, FGF9, PTPN11, PTHLH, TGFB2
11MP:00053897.9E2F1, BMPR1B, BMP2, FGFR3, FGF9, PTPN11
12MP:00028737.8EXT1, E2F1, BMP2, FGFR1, FGFR3, FGF9
13MP:00053697.6E2F1, FGFR1, FGF9, FGF2, ACVR1, PTPN11
14MP:00053827.6EXT1, BMPR1B, BMP2, FGFR1, FGFR3, FGF9
15MP:00053867.3EXT1, E2F1, NES, FGFR1, FGFR3, FGF9
16MP:00053817.3FGFR1, BMP2, E2F1, EXT1, FGFR3, FGF9
17MP:00053857.2E2F1, BMP2, FGFR1, FGF9, FGF2, ACVR1
18MP:00053916.9EXT1, E2F1, BMPR1B, FGFR1, FGFR3, FGF9
19MP:00053786.3EXT1, E2F1, BMPR1B, BMP2, NES, FGFR1
20MP:00053845.9NES, BMP2, BMPR1B, E2F1, EXT1, FGFR1
21MP:00107685.7NES, BMP2, BMPR1B, E2F1, EXT2, EXT1

Publications for Osteochondroma

Sources:
51PubMed
See all sources

Articles related to Osteochondroma:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas. (23412166)
2013
2
Osteochondroma of mandibular condyle: A clinic-radiographic correlation. (24082753)
2013
3
Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas. (23439489)
2013
4
Chondrosarcoma arising within a radiation-induced osteochondroma several years following childhood total body irradiation: case report. (23576074)
2013
5
Endosteal (central) osteochondroma of the mandibular body. (22695051)
2013
6
Cytodiagnosis of malignant transformation in a solitary osteochondroma: report of a rare case with a literature review. (23088432)
2013
7
Surgical Treatment of Osteochondroma of the Proximal Humerus: Radiographic and Early Clinical Results. (24248587)
2013
8
Endoscopic removal of the osteochondroma of the fibular head. (23985984)
2013
9
The clinical and radiographic characteristics of condylar osteochondroma. (22727110)
2012
10
Myelopathy and Quadriparesis due to Spinal Cord Compression of C1 Laminar Osteochondroma. (22439091)
2012
11
Extraskeletal osteochondroma of the medial arch of the foot. (22956660)
2012
12
What is your diagnosis? Osteochondroma. (23078559)
2012
13
Limitation of mouth opening caused by osteochondroma of the coronoid process. (21719327)
2011
14
Osteochondroma of the temporomandibular joint treated by means of condylectomy and immediate reconstruction with a total stock prosthesis. (24421981)
2011
15
Enlargement of a humeral osteochondroma after skeletal maturity: a case report. (21411695)
2011
16
Radiographic evidence of regression of a solitary osteochondroma: a report of 4 cases and a literature review. (21415692)
2011
17
Subacromial osteochondroma. (21902162)
2011
18
Pseudoaneurysm of the popliteal artery due to osteochondroma of the distal femur. (20737389)
2010
19
Large osteochondroma of the mandibular condyle treated by condylectomy using a transzygomatic approach. (20060265)
2010
20
Solitary osteochondroma of the proximal femur and femoral acetabular impingement. (20055356)
2010
21
Pseudoaneurysm overlying an osteochondroma: a noteworthy complication. (21103904)
2010
22
Osteochondroma of the condyle: review of 8 cases. (20346630)
2010
23
Costal osteochondroma causing pneumothorax in an adolescent: a case report and review of the literature. (21034955)
2010
24
Muenke syndrome with osteochondroma. (19097163)
2009
25
Fracture of an osteochondroma treated successfully with total excision: two case reports. (19918447)
2009
26
Intracapsular osteochondroma of the humeral head in an adult causing restriction of motion: a case report. (19131258)
2009
27
Giant osteochondroma of the posterior cavity of the knee. (19226081)
2008
28
Para-articular osteochondroma of the knee. (17681220)
2007
29
Osteochondroma of the mandible causing severe facial asymmetry: a case report. (17331758)
2007
30
Solitary osteochondroma causing popliteal pseudoaneurysm that presented as a mass lesion. (18092290)
2007
31
Secondary synovial chondromatosis in a bursa overlying an osteochondroma mimicking a peripheral chondrosarcoma -- a case report. (17966034)
2007
32
Osteochondroma of the glenoid fossa--a case report. (17023103)
2007
33
Cortico-medullary continuity in bizarre parosteal osteochondromatous proliferation mimicking osteochondroma on imaging. (17437102)
2007
34
General practitioner's radiology case 58. Osteochondroma. (18260553)
2007
35
Osteochondroma of the phalanx: a late Roman case. (17689539)
2007
36
Rapid development of an osteosarcoma after surgical resection of an osteochondroma. (17717463)
2007
37
Osteochondroma of the coronoid process. (16648770)
2006
38
Resorption of osteochondroma by accompanying pseudoaneurysm. (16037510)
2005
39
Spinal cord compression due to vertebral osteochondroma: report of two cases. (15797501)
2005
40
Arthroscopic resection of an osteochondroma of the knee. (11536098)
2001
41
Osteochondroma of the C5 lamina with cord compression: case report and review of the literature. (10806510)
2000
42
Cervical myelopathy due to an osteochondroma in a 73-year-old female. The oldest case in the literature. (10983260)
2000
43
A conservative surgical approach of osteochondroma affecting the mandibular condyle. (9707922)
1998
44
Dural osteochondroma: case report, review of the literature and proposal of a new classification. (10070437)
1998
45
Dominant carpotarsal osteochondromatosis. (8411062)
1993
46
Multiple exostosis (osteochondroma) and Wilms' tumour--a possible association by Walker et al., 1991. (1318997)
1992
47
Cervical osteochondroma (C2 level) with vertebral artery occlusion and second cervical nerve root irritation. (2718087)
1989
48
Case report 545: Osteochondroma (osteocartilagenous exostosis) cervical spine with spinal cord compression. (2675321)
1989
49
Case report 522: Concurrent adjacent osteochondroma and enchondroma. (2711213)
1989
50
Osteochondroma of the cervical spine: a cause of transient quadriplegia. (460559)
1979

Genetic Variations for Osteochondroma

Expression for genes affiliated with Osteochondroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 50PharmGKB, 4Cell Signaling Technology, 12EMD Millipore, 53R&D Systems, 56SinoBiological, 60Tocris Bioscience
See all sources

Pathways related to Osteochondroma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2FGFR3
2
Hide members
9.9FGF9, BMP2
3
Hide members
9.8FGF9, FGFR1
49.7BMP2, BMPR1B
59.7BMP2, BMPR1B
6
Hide members
9.6BMP2, FGFR1, FGFR3
7
Hide members
9.6PTPN11, FGF2
8
Hide members
9.6FGF9, FGFR3, FGFR1
99.4FGF2, FGFR3, FGFR1
109.4FGF2, FGFR3, FGFR1
119.4FGF2, FGFR3, FGFR1
129.4TGFB2, FGF2, FGFR1
13
Hide members
9.2BMP2, FGFR1, FGFR3, FGF2
149.2TGFB2, FGF2, FGFR3, FGFR1
15
Hide members
9.1FGFR1, FGFR3, FGF9, FGF2
16
Hide members
9.1FGFR1, FGFR3, FGF9, FGF2
17
Hide members
9.1FGFR1, FGFR3, FGF9, FGF2
18
Hide members
9.1FGFR1, FGFR3, FGF9, FGF2
199.1FGFR1, FGFR3, FGF9, FGF2
209.1E2F1, FGFR1, FGFR3
219.0TGFB2, ACVR1, BMP2, BMPR1B
229.0BMPR1B, BMP2, ACVR1, TGFB2
23
Hide members
9.0BMPR1B, FGFR1, FGFR3, ACVR1
24
Hide members
9.0E2F1, PTPN11, TGFB2
258.9FGFR1, FGFR3, FGF2, PTHLH, TGFB2
26
Hide members
8.9BMP2, FGFR1, FGFR3, FGF2, TGFB2
27
Hide members
8.9BMP2, FGFR1, FGFR3, FGF2, TGFB2
28
Hide members
8.9BMP2, FGFR1, FGFR3, FGF2, TGFB2
29
Hide members
8.7BMPR1B, BMP2, FGFR1, FGFR3, ACVR1
308.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
31
Hide members
8.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
32
Development FGF-family signaling
Hide members
8.7PTPN11, FGF2, FGF9, FGFR3, FGFR1
33
Hide members
8.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
34
Hide members
8.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
35
Hide members
8.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
36
Hide members
8.7FGFR1, FGFR3, FGF9, FGF2, PTPN11
378.7FGFR1, FGF9, FGF2, PTPN11, TGFB2
388.4E2F1, BMP2, FGFR3, FGF9, FGF2
39
Hide members
8.3FGF2, FGF9, FGFR3, FGFR1, E2F1
40
Hide members
8.0E2F1, BMP2, FGFR1, FGFR3, FGF9, FGF2
41
Hide members
8.0BMPR1B, BMP2, FGFR1, FGFR3, FGF2, ACVR1
42
Hide members
7.8TGFB2, ACVR1, FGF2, BMP2, BMPR1B, E2F1
43
Hide members
7.7BMPR1B, BMP2, FGFR1, FGFR3, FGF9, FGF2
44
Hide members
7.6BMPR1B, BMP2, FGFR1, FGFR3, FGF2, ACVR1
45
Hide members
7.2E2F1, BMPR1B, BMP2, FGFR1, FGFR3, FGF2

Compounds for genes affiliated with Osteochondroma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1112.5PTPN11
2pd 1615706010.2FGFR1, FGFR3
3fiin 1 hydrochloride6010.2FGFR1, FGFR3
4su 54026010.2FGFR1, FGFR3
5palifermin45 1111.1FGFR1, FGFR3
6su6668459.9FGF2, FGFR1
7su5402459.9FGFR1, FGFR3, FGF2
8pd 17307445 6010.9FGF2, FGFR3, FGFR1
9glucose459.7FGFR1, PTHLH, TGFB2
10chlorate459.7FGF2, FGFR1
11glycosaminoglycan459.6EXT1, BMP2, FGF2, TGFB2
12heparin45 29 11 2412.6EXT1, BMP2, POMGNT2, FGF9
13dihydrotestosterone45 29 11 2412.6BMP2, FGF2, PTHLH, TGFB2
14ribonucleic acid459.5BMP2, FGFR1, PTHLH, TGFB2
15calcitriol45 60 11 2412.5BMP2, FGF2, PTHLH, TGFB2
16paclitaxel45 50 1111.4DUSP19, E2F1
17sodium chlorate459.4FGF2, FGFR1
18dexamethasone45 50 29 1112.3BMP2, DUSP19, FGF2, TGFB2
19paraffin459.2NES, FGFR3, FGF2, PTHLH, TGFB2
20nicotine45 50 29 1112.2BMP2, DUSP19, FGF2, PTHLH
21arginine459.2EXT1, EXT2, BMP2, FGFR3, PTPN11, PTHLH
22sb 20358045 6010.1PTPN11, FGF2, FGFR1, BMP2
23chondroitin sulfate45 2410.1FGF2, FGFR1, POMGNT2
24phosphotyrosine459.0DUSP19, FGFR1, FGFR3, PTPN11
25matrigel459.0BMP2, NES, FGF9, FGF2, PTHLH, TGFB2
26tetracycline45 119.9E2F1, BMP2, FGF2, PTPN11
27dopamine45 29 11 2411.9BMP2, NES, DUSP19, FGFR1, TGFB2
28genistein45 29 60 2 11 2413.8BMP2, DUSP19, FGFR1, FGF2, TGFB2
29tgf beta1458.8E2F1, BMP2, FGF2, PTHLH, TGFB2
30polysaccharide458.6FGF2, FGFR1, POMGNT2, DUSP19, BMP2
31heparan sulfate45 249.6EXT1, EXT2, BMP2, POMGNT2, FGFR1, FGF2
32progesterone45 60 29 11 2412.5E2F1, BMP2, NES, FGFR1, PTHLH, TGFB2
33lysine458.5E2F1, BMP2, FGFR1, FGFR3, PTPN11, PTHLH
34testosterone45 60 11 2411.5E2F1, BMP2, FGFR1, PTHLH, TGFB2
35ascorbic acid45 249.4E2F1, BMP2, DUSP19, FGF2, TGFB2
36agar458.3E2F1, FGFR1, FGF2, PTPN11, PTHLH, TGFB2
37rapamycin458.2E2F1, BMP2, DUSP19, POMGNT2, PTPN11
38nitric oxide45 11 2410.2E2F1, BMP2, NES, FGFR1, PTPN11, PTHLH
39oligonucleotide458.1E2F1, BMP2, FGFR1, FGFR3, ACVR1, PTPN11
40cysteine458.1BMP2, DUSP19, POMGNT2, FGFR1, FGFR3, PTPN11
41thymidine45 249.1E2F1, BMP2, FGFR1, FGF2, PTPN11, PTHLH
42bromodeoxyuridine458.0TGFB2, E2F1, NES, FGFR1, FGF2, PTPN11
43threonine457.9BMPR1B, BMP2, DUSP19, FGFR1, FGFR3, ACVR1
44calcium45 50 11 2410.7BMP2, DUSP19, FGFR1, FGFR3, FGF9, ACVR1
45phosphatidylinositol457.7E2F1, DUSP19, FGFR1, FGF2, PTPN11, PTHLH
46lipid457.6E2F1, BMP2, NES, DUSP19, FGFR1, FGFR3
47vegf457.2E2F1, BMP2, NES, FGFR1, FGFR3, FGF9
48retinoic acid45 248.0E2F1, BMP2, NES, DUSP19, POMGNT2, FGFR1
49tyrosine456.1E2F1, BMPR1B, BMP2, NES, DUSP19, FGFR1
50serine455.8POMGNT2, DUSP19, BMP2, BMPR1B, E2F1, FGFR1

GO Terms for genes affiliated with Osteochondroma

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteochondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9TGFB2, PTHLH, FGF2, FGF9, BMP2
2extracellular regionGO:0055768.0TGFB2, BMP2, FGFR1, FGFR3, FGF9, FGF2

Biological processes related to Osteochondroma according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:03369210.4EXT1, EXT2
2heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:01501410.4EXT1, EXT2
3positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.2FGFR1, FGFR3
4positive regulation of phospholipase activityGO:01051810.2FGFR1, FGFR3
5positive regulation of ossificationGO:04577810.2TGFB2, BMP2
6mesenchymal cell differentiationGO:04876210.2BMP2, FGFR1
7substantia nigra developmentGO:02176210.2FGFR3, FGF2
8cardiac epithelial to mesenchymal transitionGO:06031710.2TGFB2, BMP2
9heparan sulfate proteoglycan biosynthetic processGO:01501210.1EXT2, EXT1
10corticotropin hormone secreting cell differentiationGO:06012810.1BMP2, FGF2
11thyroid-stimulating hormone-secreting cell differentiationGO:06012910.1FGF2, BMP2
12lung-associated mesenchyme developmentGO:06048410.1FGF9, FGFR1
13positive regulation of phospholipase C activityGO:01086310.0FGFR1, FGF2
14pathway-restricted SMAD protein phosphorylationGO:06038910.0BMP2, ACVR1, TGFB2
15embryonic digestive tract developmentGO:0485669.9TGFB2, FGF9
16positive regulation of endothelial cell proliferationGO:0019389.9BMP2, FGFR3, FGF2
17organ inductionGO:0017599.8FGF2, FGFR1
18positive regulation of cell divisionGO:0517819.8TGFB2, FGF2, FGF9
19positive regulation of cardiac muscle cell proliferationGO:0600459.8FGFR1, FGF9, FGF2
20chondrocyte differentiationGO:0020629.8FGF9, FGFR3, FGFR1, BMP2
21positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGF2, FGFR3, BMP2
22positive regulation of bone mineralizationGO:0305019.7ACVR1, BMP2, BMPR1B
23cell-cell signalingGO:0072679.7TGFB2, PTHLH, FGF9, BMP2
24BMP signaling pathwayGO:0305099.6ACVR1, BMP2, BMPR1B
25eye developmentGO:0016549.6BMPR1B, TGFB2
26activation of MAPK activityGO:0001879.6BMP2, FGF2, PTPN11
27heart developmentGO:0075079.5TGFB2, PTPN11, BMP2
28axon guidanceGO:0074119.4EXT1, FGFR1, PTPN11, TGFB2
29cartilage condensationGO:0015029.4TGFB2, BMPR1B
30negative regulation of cell proliferationGO:0082859.3BMP2, FGF2, PTHLH, TGFB2
31positive regulation of osteoblast differentiationGO:0456699.3ACVR1, FGF2, BMP2, BMPR1B
32positive regulation of gene expressionGO:0106289.2E2F1, BMP2, FGF9, TGFB2
33phosphatidylinositol-mediated signalingGO:0480159.1FGFR1, FGFR3, FGF9, FGF2, PTPN11
34insulin receptor signaling pathwayGO:0082869.1PTPN11, FGF2, FGF9, FGFR3, FGFR1
35fibroblast growth factor receptor signaling pathwayGO:0085439.1FGFR1, FGFR3, FGF9, FGF2, PTPN11
36Fc-epsilon receptor signaling pathwayGO:0380959.1FGFR1, FGFR3, FGF9, FGF2, PTPN11
37epidermal growth factor receptor signaling pathwayGO:0071739.1PTPN11, FGF2, FGF9, FGFR3, FGFR1
38positive regulation of MAPK cascadeGO:0434109.1BMP2, DUSP19, FGFR1, FGFR3, FGF9
39neurotrophin TRK receptor signaling pathwayGO:0480119.1PTPN11, FGF2, FGF9, FGFR3, FGFR1
40protein phosphorylationGO:0064689.1TGFB2, ACVR1, FGFR1, BMP2, BMPR1B
41skeletal system developmentGO:0015019.1PTHLH, FGFR3, FGFR1, BMP2, BMPR1B, EXT1
42innate immune responseGO:0450879.0FGFR1, FGFR3, FGF9, FGF2, PTPN11
43positive regulation of cell proliferationGO:0082849.0TGFB2, PTHLH, FGF2, FGF9, FGFR3, FGFR1

Molecular functions related to Osteochondroma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:05050910.3EXT1, EXT2
2heparan sulfate N-acetylglucosaminyltransferase activityGO:04232810.3EXT1, EXT2
3glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:05050810.2EXT1, EXT2
4fibroblast growth factor-activated receptor activityGO:00500710.0FGFR3, FGFR1
5transferase activity, transferring glycosyl groupsGO:01675710.0EXT2, EXT1
6peptide hormone receptor bindingGO:0514289.8PTPN11, PTHLH
7acetylglucosaminyltransferase activityGO:0083759.8EXT1, EXT2, POMGNT2
8transforming growth factor beta receptor activity, type IGO:0050259.8BMPR1B, ACVR1
9fibroblast growth factor bindingGO:0171349.7FGF2, FGFR3, FGFR1
10transmembrane receptor protein serine/threonine kinase activityGO:0046759.7ACVR1, BMPR1B
11receptor signaling protein serine/threonine kinase activityGO:0047029.6TGFB2, ACVR1, BMPR1B
12SMAD bindingGO:0463329.6ACVR1, BMP2, BMPR1B
13protein heterodimerization activityGO:0469829.4TGFB2, BMP2, EXT2, EXT1
14growth factor activityGO:0080839.4TGFB2, FGF2, FGF9, BMP2
15protein homodimerization activityGO:0428039.1EXT1, EXT2, FGFR1, ACVR1, TGFB2
16heparin bindingGO:0082019.1FGFR1, FGF9, FGF2

Products for genes affiliated with Osteochondroma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet