MCID: OST028
MIFTS: 54

Osteochondroma malady

Genetic diseases, Rare diseases, Bone diseases categories

Summaries for Osteochondroma

About this section


Wikipedia:64 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and exostosis. An important gene associated with Osteochondroma is EXT2 (exostosin glycosyltransferase 2), and among its related pathways are heparan sulfate biosynthesis and Signaling events mediated by the Hedgehog family. The compounds su 5402 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Osteochondroma

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Osteochondroma, Aliases & Descriptions:

Name: Osteochondroma 42 44
 
Cartilaginous Exostosis 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases


Related Diseases for Osteochondroma

About this section

Diseases in the Hereditary Multiple Osteochondromas family:

osteochondroma

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary multiple osteochondromas31.5EXT2, EXT1
2exostosis31.4EXT2, EXT1
3hereditary multiple exostoses31.1EXT1, EXT2, POMGNT2
4fibrodysplasia ossificans progressiva30.6ACVR1, BMP2
5muenke syndrome30.5FGFR3, FGFR1
6synostosis30.2FGFR3, FGFR1
7osteosarcoma30.1EXT1, BMP2, DUSP19, E2F1, TGFB2, PTHLH
8sarcoma30.1BMP2, EXT2, EXT1, E2F1, NES
9keloids29.9FGF2, TGFB2
10chondrosarcoma29.5FGFR3, FGF2, FGFR1, EXT1, EXT2, BMP2
11adenocarcinoma29.2TGFB2, POMGNT2, E2F1, PTHLH, NES, FGFR1
12cervicitis10.6
13thanatophoric dysplasia10.5FGFR3
14primary pulmonary hypertension10.5BMP2
15osteoglophonic dysplasia10.4FGFR1
16autosomal dominant disease10.4EXT2, EXT1
17achondroplasia10.4FGF9, FGFR3
18seborrheic keratosis10.3TGFB2, FGFR3
19ollier disease10.3EXT2, EXT1, PTHLH
20hypochondroplasia10.3FGFR3, FGFR1
21dysplasia epiphysealis hemimelica10.3
22metachondromatosis10.3
23pilocytic astrocytoma10.3NES
24fgfr-related craniosynostosis syndromes10.3FGFR1, FGFR3
25jackson-weiss syndrome10.3FGFR3, FGFR1
26infectious mononucleosis10.3FGFR1, FGFR3
27osteoporosis, postmenopausal10.3PTHLH, TGFB2
28acrocephalosyndactylia10.3FGFR3, FGFR1
29chondroma10.3
30saethre-chotzen syndrome10.3FGFR3, FGFR1
31malignant fibroxanthoma10.2DUSP19, BMP2
32bone cancer10.2PTHLH, BMP2, EXT1, EXT2
33malignant peripheral nerve sheath tumor10.2NES, BMP2
34secondary syphilis10.2EXT1, EXT2, BMP2, PTHLH
35progressive osseous heteroplasia10.2ACVR1, BMP2
36bursitis10.2
37enchondroma10.2
38synovial chondromatosis10.2
39pancreatic cancer10.2NES, PTHLH, TGFB2
40skeletal dysplasia multi-gene panels10.2PTHLH, FGFR1, FGFR3
41dwarfism10.2PTHLH, FGFR3, FGFR1
42lymphoblastic lymphoma10.2FGFR1, E2F1
43proliferative vitreoretinopathy10.2TGFB2, FGF2
44brachydactyly type a210.2BMPR1B, BMP2
45brachydactyly10.2FGFR3, BMPR1B
46pseudoarthrosis10.1
47aneurysm10.1
48medulloblastoma10.1BMP2, NES, E2F1
49crouzon syndrome10.1FGFR1, FGF2, FGFR3
50hematopoietic stem cell transplantation10.1

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms for Osteochondroma

About this section

Drugs & Therapeutics for Osteochondroma

About this section

Drug clinical trials:

Search ClinicalTrials for Osteochondroma

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

About this section

Anatomical Context for Osteochondroma

About this section

MalaCards organs/tissues related to Osteochondroma:

32
Bone, Spinal cord, Bone marrow, Lymph node, Liver, Breast, Uterus, Testes, Tongue, Appendix

Animal Models for Osteochondroma or affiliated genes

About this section

MGI Mouse Phenotypes related to Osteochondroma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5FGF9, FGFR3, E2F1, TGFB2, PTHLH
2MP:00028738.2E2F1, BMP2, EXT1, FGFR3, FGF9
3MP:00020068.2E2F1, ACVR1, EXT1, FGF2, FGFR3
4MP:00107718.1PTHLH, E2F1, EXT1, FGFR1, FGFR3, FGF9
5MP:00053798.1PTHLH, TGFB2, E2F1, BMPR1B, FGFR1, FGF9
6MP:00053717.9PTHLH, TGFB2, ACVR1, BMPR1B, BMP2, EXT1
7MP:00053697.9TGFB2, E2F1, ACVR1, FGFR1, FGF2, FGF9
8MP:00053827.9PTHLH, TGFB2, ACVR1, BMPR1B, BMP2, EXT1
9MP:00053817.5PTHLH, TGFB2, E2F1, ACVR1, BMP2, EXT1
10MP:00053897.5PTHLH, TGFB2, E2F1, BMPR1B, BMP2, FGF2
11MP:00053857.4PTHLH, TGFB2, E2F1, ACVR1, BMP2, FGFR1
12MP:00053767.4PTHLH, TGFB2, E2F1, ACVR1, BMP2, FGF2
13MP:00053777.3TGFB2, E2F1, ACVR1, BMP2, EXT1, FGFR1
14MP:00053807.3TGFB2, E2F1, NES, ACVR1, BMPR1B, BMP2
15MP:00053917.2PTHLH, TGFB2, E2F1, BMPR1B, EXT1, FGFR1
16MP:00053867.1PTHLH, E2F1, NES, ACVR1, EXT1, FGFR1
17MP:00053786.7NES, E2F1, TGFB2, PTHLH, ACVR1, BMPR1B
18MP:00036316.5PTHLH, TGFB2, E2F1, NES, ACVR1, BMPR1B
19MP:00053906.3FGF9, PTHLH, TGFB2, E2F1, ACVR1, BMPR1B
20MP:00053846.2ACVR1, NES, E2F1, TGFB2, PTHLH, BMPR1B
21MP:00107686.0ACVR1, NES, E2F1, TGFB2, PTHLH, BMPR1B

Publications for Osteochondroma

About this section

Articles related to Osteochondroma:

(show top 50)    (show all 587)
idTitleAuthorsYear
1
Osteochondroma of the glenoid fossa-report of two cases with sudden onset of symptoms. (25277805)
2014
2
Low condylectomy and orthognathic surgery to treat mandibular condylar osteochondroma: a retrospective review of 37 cases. (24997022)
2014
3
Osteochondroma of the palate: An interesting and an unusual case presentation. (25328318)
2014
4
Synovial chondromatosis of pes anserine bursa secondary to osteochondroma. (25102510)
2014
5
Letter regarding "Effect of osteochondroma location on forearm deformity in patients with multiple hereditary osteochondromatosis". (23790427)
2013
6
Transformation of solitary osteochondroma to dedifferentiated chondrosarcoma arising in the distal radius: a case report. (23007379)
2013
7
Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas. (23412166)
2013
8
Osteochondroma of mandibular condyle: A clinic-radiographic correlation. (24082753)
2013
9
Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency. (23384194)
2013
10
Solitary osteochondroma arising from cervical spina bifida occulta. (24383028)
2013
11
Osteochondroma as a cause of scapular winging in an adolescent: a case report and review of the literature. (23971723)
2013
12
Giant costal osteochondroma in a man with multiple exostoses. (23910108)
2013
13
Osteochondroma of the temporomandibular joint: report of 2 cases emphasizing the importance of personalizing the surgical treatment. (22669156)
2012
14
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (22246151)
2012
15
Isolated osteochondroma of the femoral neck presenting as hip and leg pain. A case study. (22619103)
2012
16
Malignant degeneration of a lumbar osteochondroma into a chondrosarcoma which mimicked a large retropertioneal mass. (22526879)
2012
17
3-D printout of a DICOM file to aid surgical planning in a 6 year old patient with a large scapular osteochondroma complicating congenital diaphyseal aclasia. (22690278)
2012
18
A synovial osteochondroma replacing the anterior cruciate ligament at the intercondylar notch. (21323282)
2011
19
Computer-assisted surgical planning and simulation for condylar reconstruction in patients with osteochondroma. (20427106)
2011
20
Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. (21506131)
2011
21
Scapular osteochondroma treated with arthroscopic excision using prone positioning. (20396684)
2010
22
Cervical spine osteochondroma: rare presentation of a common lesion. (21109061)
2010
23
Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. (20012156)
2010
24
A rare anterior sacral osteochondroma presenting as sciatica in an adult: a case report and review of the literature. (20421072)
2010
25
Resected osteochondroma of the rib in an elderly patient. (21069500)
2010
26
A multilobed osteochondroma of the hamate: case report. (19695798)
2009
27
Osteochondroma of the mandibular condyle: Resection and reconstruction using vertical sliding osteotomy of the mandibular ramus. (19333189)
2009
28
Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. (18196252)
2008
29
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. (17301954)
2007
30
Phalangeal osteochondroma. (17323627)
2007
31
Discomfort during sexual intercourse secondary to osteochondroma: a report of two cases. (17588798)
2007
32
Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. (17226760)
2007
33
Osteochondroma of the skull base. (17599588)
2007
34
An optimized DHPLC protocol for molecular testing of the EXT1 and EXT2 genes in hereditary multiple osteochondromas. (16283885)
2005
35
A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica? (14564279)
2003
36
Extraskeletal osteochondroma of the buttock. (12589103)
2003
37
Condylar osteochondroma with complete hearing loss: report of a case. (12524621)
2003
38
Arterial compromise caused by lower limb osteochondroma. (12799727)
2003
39
Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage. (12472121)
2002
40
Osteochondroma of the posterior nasal septum managed by endoscopic transnasal transseptal approach. (12487678)
2002
41
Two cases of osteochondroma recurrence after surgical resection. (11198832)
2001
42
Osteochondroma of the C5 lamina with cord compression: case report and review of the literature. (10806510)
2000
43
Cervical myelopathy due to an osteochondroma in a 73-year-old female. The oldest case in the literature. (10983260)
2000
44
Osteochondroma of the tracheal wall in a Fischer's lovebird (Agapornis fischeri, Reichenow 1887). (10216774)
1999
45
Scaphoid osteochondroma. (9457602)
1997
46
Dysplasia epiphysealis hemimelica. Upper limb involvement with associated osteochondroma. (7924021)
1994
47
Cervical osteochondroma (C2 level) with vertebral artery occlusion and second cervical nerve root irritation. (2718087)
1989
48
Osteochondroma with thoracic cord compression in hereditary multiple exostoses: a case report. (312508)
1979
49
Osteochondroma of the cervical spine: a cause of transient quadriplegia. (460559)
1979
50
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. (5803809)
1969

Variations for Osteochondroma

About this section

Expression for genes affiliated with Osteochondroma

About this section
Expression patterns in normal tissues for genes affiliated with Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

About this section

Pathways related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
heparan sulfate biosynthesis (late stages)37
10.0EXT1, EXT2
29.9TGFB2, PTHLH
39.8BMP2, BMPR1B
49.6FGF2, FGFR1
59.5TGFB2, BMPR1B, BMP2
6
Show member pathways
9.3BMP2, BMPR1B, ACVR1
79.3FGFR3, FGF2, FGFR1
89.3FGFR3, FGF2, FGFR1
9
Show member pathways
9.3FGFR3, FGF2, FGFR1
109.3TGFB2, FGFR1, FGF2
11
Show member pathways
9.0BMP2, BMPR1B, ACVR1, TGFB2
129.0TGFB2, ACVR1, BMPR1B, BMP2
139.0FGFR3, FGFR1, E2F1
149.0TGFB2, FGFR1, FGF2, FGFR3
15
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
16
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
17
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
189.0FGFR1, FGF2, FGFR3, FGF9
19
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
20
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
21
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
22
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
23
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
24
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
25
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
26
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
279.0TGFB2, FGFR1, FGF2, FGF9
28
Show member pathways
9.0ACVR1, BMPR1B, FGFR1, FGFR3
298.8E2F1, FGFR1, FGF2
308.8PTHLH, TGFB2, FGFR1, FGF2, FGFR3
31
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
32
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
33
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
34
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
35
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
36
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
37
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
38
Show member pathways
MAPK signaling pathway37
8.7TGFB2, FGFR1, FGF2, FGFR3, FGF9
398.5EXT2, EXT1, FGFR1, FGF2, FGFR3, FGF9
40
Show member pathways
8.4TGFB2, BMP2, FGFR1, FGF2, FGFR3, FGF9
41
Show member pathways
8.4TGFB2, ACVR1, BMPR1B, BMP2, FGFR1, FGFR3
42
Show member pathways
8.2E2F1, FGFR1, FGF2, FGFR3, FGF9
43
Show member pathways
Signaling Pathways in Glioblastoma37
8.2E2F1, FGFR1, FGF2, FGFR3, FGF9
44
Show member pathways
7.9FGF2, FGFR1, BMP2, BMPR1B, ACVR1, TGFB2
45
Show member pathways
7.9TGFB2, FGFR3, FGF2, FGFR1, BMP2, BMPR1B
46
Show member pathways
7.7TGFB2, E2F1, ACVR1, BMPR1B, BMP2, FGF2
47
Show member pathways
7.6TGFB2, E2F1, BMP2, FGFR1, FGF2, FGFR3
487.6FGF9, TGFB2, E2F1, BMP2, FGFR1, FGF2
49
Show member pathways
7.2PTHLH, E2F1, BMPR1B, BMP2, FGFR1, FGF2
50
Show member pathways
7.0TGFB2, E2F1, ACVR1, BMPR1B, BMP2, FGFR1

Compounds for genes affiliated with Osteochondroma

About this section

Compounds related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1su 54026010.1FGFR3, FGFR1
2fiin 1 hydrochloride6010.0FGFR3, FGFR1
3pd 1615706010.0FGFR3, FGFR1
4palifermin44 1210.8FGFR1, FGFR3
5su5402449.7FGFR3, FGFR1, FGF2
6pd 17307444 6010.7FGFR1, FGFR3, FGF2
7su6668449.7FGFR1, FGF2
8alginate449.7BMP2, TGFB2, FGF2
9glycosaminoglycan449.5TGFB2, EXT1, FGF2, BMP2
10dihydrotestosterone44 29 25 1212.5PTHLH, TGFB2, BMP2, FGF2
11ribonucleic acid449.5BMP2, PTHLH, FGFR1, TGFB2
12calcitriol44 60 25 1212.4TGFB2, BMP2, FGF2, PTHLH
13paraffin449.2FGFR3, TGFB2, NES, FGF2, PTHLH
14nicotine44 29 50 1212.1FGF2, PTHLH, DUSP19, BMP2
15chondroitin sulfate44 2510.1POMGNT2, FGF2, FGFR1
16forskolin44 50 1211.0FGFR1, PTHLH, BMP2, DUSP19, TGFB2
17matrigel448.9NES, FGF2, PTHLH, BMP2, FGF9, TGFB2
18dopamine44 29 25 1211.9FGFR1, BMP2, NES, DUSP19, TGFB2
19pge2448.9PTHLH, FGF2, BMP2, DUSP19, TGFB2
20lysine448.8FGFR3, PTHLH, E2F1, BMP2, FGFR1
21tgf beta1448.7PTHLH, BMP2, FGF2, E2F1, TGFB2
22genistein44 29 60 3 25 1213.7FGF2, FGFR1, BMP2, DUSP19, TGFB2
23agar448.6E2F1, TGFB2, PTHLH, FGFR1, FGF2
24dexamethasone44 50 29 1211.6DUSP19, PTHLH, TGFB2, BMP2, FGF2, FGFR3
25testosterone44 60 25 1211.6TGFB2, PTHLH, E2F1, BMP2, FGFR1
26polysaccharide448.6POMGNT2, DUSP19, BMP2, FGFR1, FGF2
27tetracycline44 129.6FGF2, E2F1, BMP2
28steroid448.5BMP2, FGFR1, E2F1, TGFB2, PTHLH
29progesterone44 29 60 25 1212.5E2F1, FGFR1, BMP2, TGFB2, PTHLH, NES
30heparan sulfate44 259.5EXT2, EXT1, FGFR1, FGF2, BMP2, POMGNT2
31nitric oxide44 25 1210.5BMP2, FGFR1, PTHLH, TGFB2, E2F1, NES
32oligonucleotide448.4FGFR3, FGFR1, BMP2, E2F1, TGFB2, ACVR1
33thymidine44 259.4TGFB2, PTHLH, FGF2, FGFR1, BMP2, E2F1
34cysteine448.4FGFR1, TGFB2, BMP2, FGFR3, DUSP19, POMGNT2
35ascorbic acid44 259.3FGF2, BMP2, DUSP19, TGFB2, E2F1
36bromodeoxyuridine448.3NES, PTHLH, TGFB2, E2F1, FGFR1, FGF2
37paclitaxel44 50 1210.3FGF2, E2F1, PTHLH, FGFR1, DUSP19
38threonine448.2BMPR1B, BMP2, FGFR3, ACVR1, DUSP19, PTHLH
39rapamycin448.1BMP2, DUSP19, POMGNT2, E2F1
40heparin44 29 25 1211.1FGF2, PTHLH, TGFB2, POMGNT2, FGF9, EXT1
41cycloheximide448.1FGF2, DUSP19, E2F1, BMP2, TGFB2, PTHLH
42glutamate448.1TGFB2, E2F1, DUSP19, NES, FGFR1, FGFR3
43phosphatidylinositol448.0FGF2, FGFR1, DUSP19, E2F1, PTHLH, TGFB2
44calcium44 50 25 1211.0FGF9, FGFR3, PTHLH, TGFB2, FGFR1, BMP2
45lipid447.9BMP2, PTHLH, FGFR1, FGFR3, NES, DUSP19
46vegf447.4PTHLH, FGFR3, TGFB2, E2F1, NES, BMP2
47estrogen447.1FGF2, NES, PTHLH, TGFB2, E2F1, DUSP19
48retinoic acid44 257.9PTHLH, TGFB2, E2F1, DUSP19, NES, FGFR1
49tyrosine446.4BMPR1B, NES, DUSP19, E2F1, TGFB2, PTHLH
50serine446.1POMGNT2, E2F1, PTHLH, FGF2, FGFR1, BMP2

GO Terms for genes affiliated with Osteochondroma

About this section

Cellular components related to Osteochondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.2FGFR3, EXT1, EXT2, POMGNT2
2extracellular spaceGO:0056158.5PTHLH, TGFB2, BMP2, FGF2, FGF9
3extracellular regionGO:0055768.1FGF9, FGFR3, FGF2, FGFR1, BMP2, TGFB2

Biological processes related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:03369210.4EXT2, EXT1
2heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:01501410.4EXT1, EXT2
3heparan sulfate proteoglycan biosynthetic processGO:01501210.3EXT1, EXT2
4cardiac epithelial to mesenchymal transitionGO:06031710.2BMP2, TGFB2
5positive regulation of ossificationGO:04577810.2BMP2, TGFB2
6positive regulation of phospholipase activityGO:01051810.2FGFR1, FGFR3
7endoderm developmentGO:00749210.2PTHLH, EXT1
8mesenchymal cell differentiationGO:04876210.2BMP2, FGFR1
9positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.2FGFR1, FGFR3
10embryonic digestive tract developmentGO:04856610.1FGF9, TGFB2
11lung-associated mesenchyme developmentGO:06048410.1FGF9, FGFR1
12corticotropin hormone secreting cell differentiationGO:06012810.1FGF2, BMP2
13thyroid-stimulating hormone-secreting cell differentiationGO:06012910.1FGF2, BMP2
14positive regulation of epithelial to mesenchymal transitionGO:01071810.0TGFB2, BMP2
15eye developmentGO:00165410.0BMPR1B, TGFB2
16cartilage condensationGO:0015029.9BMPR1B, TGFB2
17pathway-restricted SMAD protein phosphorylationGO:0603899.9TGFB2, ACVR1, BMP2
18positive regulation of phospholipase C activityGO:0108639.9FGF2, FGFR1
19organ inductionGO:0017599.9FGF2, FGFR1
20positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.9ACVR1, BMP2
21endochondral ossificationGO:0019589.9PTHLH, FGFR3
22response to axon injuryGO:0486789.8FGFR3, FGF2
23positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8FGF2, FGFR3
24positive regulation of cell cycleGO:0457879.8FGFR1, TGFB2
25positive regulation of endothelial cell proliferationGO:0019389.8FGFR3, FGF2, BMP2
26positive regulation of bone mineralizationGO:0305019.8ACVR1, BMPR1B, BMP2
27substantia nigra developmentGO:0217629.8FGFR3, FGF9, FGF2
28positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGFR3, BMP2, FGF2
29positive regulation of cell divisionGO:0517819.7TGFB2, FGF2, FGF9
30BMP signaling pathwayGO:0305099.7BMPR1B, BMP2, ACVR1
31positive regulation of cardiac muscle cell proliferationGO:0600459.7FGF2, FGF9, FGFR1
32cell-cell signalingGO:0072679.5BMP2, FGFR3, FGF9, PTHLH, TGFB2
33angiogenesisGO:0015259.5FGF9, TGFB2, FGFR1
34negative regulation of cell proliferationGO:0082859.5FGF2, PTHLH, BMP2, TGFB2
35positive regulation of cell differentiationGO:0455979.4FGFR3, BMPR1B
36phosphatidylinositol-mediated signalingGO:0480159.4FGFR1, FGF2, FGFR3, FGF9
37insulin receptor signaling pathwayGO:0082869.4FGF2, FGFR1, FGF9, FGFR3
38fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR1, FGF2, FGFR3, FGF9
39Fc-epsilon receptor signaling pathwayGO:0380959.4FGFR1, FGF9, FGFR3, FGF2
40epidermal growth factor receptor signaling pathwayGO:0071739.4FGFR1, FGF2, FGFR3, FGF9
41neurotrophin TRK receptor signaling pathwayGO:0480119.3FGFR3, FGF9, FGF2, FGFR1
42positive regulation of osteoblast differentiationGO:0456699.3ACVR1, FGF2, BMPR1B, BMP2
43chondrocyte differentiationGO:0020629.2FGFR1, FGFR3, BMPR1B, BMP2, FGF9
44positive regulation of gene expressionGO:0106289.2BMP2, FGF9, E2F1, TGFB2
45protein phosphorylationGO:0064689.1TGFB2, ACVR1, BMPR1B, BMP2, FGFR1
46positive regulation of MAPK cascadeGO:0434109.1DUSP19, FGFR3, BMP2, FGFR1, FGF9
47skeletal system developmentGO:0015019.0PTHLH, BMPR1B, BMP2, EXT1, FGFR1, FGFR3
48positive regulation of cell proliferationGO:0082848.9FGF9, PTHLH, FGFR3, FGF2, FGFR1, TGFB2
49negative regulation of transcription from RNA polymerase II promoterGO:0001228.8BMP2, E2F1, FGFR1, FGFR3, FGF9
50positive regulation of transcription, DNA-templatedGO:0458938.7FGF2, BMP2, ACVR1, E2F1

Molecular functions related to Osteochondroma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:05050910.3EXT2, EXT1
2heparan sulfate N-acetylglucosaminyltransferase activityGO:04232810.3EXT2, EXT1
3glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:05050810.2EXT1, EXT2
4fibroblast growth factor-activated receptor activityGO:00500710.0FGFR1, FGFR3
5transferase activity, transferring glycosyl groupsGO:01675710.0EXT1, EXT2
6glucuronosyltransferase activityGO:01502010.0EXT1, EXT2
7transforming growth factor beta receptor activity, type IGO:0050259.8BMPR1B, ACVR1
8acetylglucosaminyltransferase activityGO:0083759.8EXT1, EXT2, POMGNT2
9transmembrane receptor protein serine/threonine kinase activityGO:0046759.8ACVR1, BMPR1B
10receptor signaling protein serine/threonine kinase activityGO:0047029.6BMPR1B, ACVR1, TGFB2
11fibroblast growth factor bindingGO:0171349.6FGFR1, FGF2, FGFR3
12SMAD bindingGO:0463329.6ACVR1, BMPR1B, BMP2
13protein heterodimerization activityGO:0469829.5EXT1, EXT2, BMP2, TGFB2
14fibroblast growth factor receptor bindingGO:0051049.5FGF9, FGF2
15growth factor activityGO:0080839.3FGF9, FGF2, BMP2, TGFB2
16heparin bindingGO:0082019.3FGFR1, FGF2, FGF9
17cytokine activityGO:0051259.1TGFB2, BMP2, FGF2
18protein homodimerization activityGO:0428039.1FGFR1, EXT1, EXT2, ACVR1, TGFB2

Products for genes affiliated with Osteochondroma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Osteochondroma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet