MCID: OST028
MIFTS: 36

Osteochondroma malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Metabolic diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Osteochondroma

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Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 45 47
 
Cartilaginous Exostosis 65

Classifications:



External Ids:

UMLS65 C0029423

Summaries for Osteochondroma

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Wikipedia:68 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to trichorhinophalangeal syndrome, type ii and hereditary multiple osteochondromas. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are Signaling events mediated by the Hedgehog family and Bladder cancer. Affiliated tissues include bone, thyroid and prostate, and related mouse phenotypes are respiratory system and embryo.

Related Diseases for Osteochondroma

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Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 433)
idRelated DiseaseScoreTop Affiliating Genes
1trichorhinophalangeal syndrome, type ii31.0EXT1, EXT2, PTHLH
2hereditary multiple osteochondromas12.7
3carpotarsal osteochondromatosis11.5
4metachondromatosis10.6
5exostoses, multiple, type 110.4
6exostoses, multiple, type 210.4
7dysplastic cortical hyperostosis10.4EXT1, EXT2
8chondroma10.4EXT1, PTHLH
9hereditary paraganglioma-pheochromocytoma syndromes10.4EXT1, EXT2
10myxoid chondrosarcoma10.3EXT1, PTHLH
11vulvar nodular hidradenoma10.3EXT1, EXT2
12anxiety disorder10.3EXT1, EXT2
13breast cancer10.3
14endotheliitis10.3
15potocki-shaffer syndrome10.3
16hereditary multiple exostoses10.3
17hepatitis10.2
18leukemia10.2
19lymphoma10.2
20irritant dermatitis10.2FGFR3, PTHLH
21eosinophilic pneumonia10.2EXT2, PTHLH
22prostatitis10.2
23agraphia10.2EXT1, EXT2, PTHLH
24hydranencephaly10.2EXT1, EXT2, PTHLH
25extratemporal epilepsy10.2FGFR3, PTHLH
26lung cancer10.2
27sarcoma10.2
28cerebritis10.2
29neuronitis10.2
30epidermolysis bullosa, pretibial10.1FGFR3, PTHLH
31myocardial infarction10.1
32prostate cancer10.1
33ischemia10.1
34bone osteosarcoma10.1PTHLH, TGFB2
35hepatitis c10.1
36pancreatitis10.1
37glioma10.1
38skeleto cardiac syndrome with thrombocytopenia10.1FGFR3, PTHLH
39clove syndrome, somatic10.0FGFR3, TGFB2
40acute myocardial infarction10.0
41atherosclerosis10.0
42charcot-marie-tooth disease10.0
43atrial fibrillation10.0
44tooth disease10.0
45melanoma10.0
46cervicitis10.0
47retinitis10.0
48adenoma10.0
49t-cell leukemia10.0
50hyperthyroidism10.0

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms for Osteochondroma

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Drugs & Therapeutics for Osteochondroma

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Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etoricoxibapproved, investigationalPhase 489202409-33-4123619
Synonyms:
202409-33-4
5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-2-(6-Methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
5-chloro-6'-Methyl-3-(P-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
5CH
AC1L3WZM
Algix
Arcoxia
C11718
C422649
CHEBI:106706
CHEBI:6339
CHEMBL416146
CID123619
D03710
DB01628
DB07166
ETORICOXIB
 
Etoricoxib
Etoricoxib (USAN/INN)
Etoricoxib [USAN:INN:BAN]
Etoricoxibe
Etoricoxibum
FT-0082494
HMS2090A05
L-791456
L001141
L791456
LS-181802
MK 0663
MK 663
MK-0663
MK-663
Merck Sharp & Dohme brand of etoricoxib
MolPort-003-847-339
NCGC00164578-01
Nucoxia
Tauxib
UNII-WRX4NFY03R
ZINC00579472
2
Tramadolapproved, investigationalPhase 421427203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Conzip
Crispin
D08623
DB00193
Durela
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
LS-57116
 
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
Ryzolt
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol Hydrochloride
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol
3Cyclooxygenase InhibitorsPhase 42225
4Peripheral Nervous System AgentsPhase 418510
5Cyclooxygenase 2 InhibitorsPhase 4538
6Antirheumatic AgentsPhase 48496
7Analgesics, Non-NarcoticPhase 45184
8Anti-Inflammatory AgentsPhase 48478
9Anti-Inflammatory Agents, Non-SteroidalPhase 43549
10AnalgesicsPhase 49358

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus SurgeryCompletedNCT00733421Phase 4
2Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
3A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus TendonRecruitingNCT01341509Phase 4
4Autologous Stem Cells in Achilles TendinopathyRecruitingNCT02064062Phase 2
5The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
6Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and KneeCompletedNCT01771393
7A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
8Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
9The Fibrodysplasia Ossificans Progressiva (FOP) Connection RegistryRecruitingNCT02745158
10Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
11Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Anatomical Context for Osteochondroma

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MalaCards organs/tissues related to Osteochondroma:

33
Bone, Thyroid, Prostate, Endothelial, Breast, Lung, T cells

Animal Models for Osteochondroma or affiliated genes

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MGI Mouse Phenotypes related to Osteochondroma:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5E2F1, FGF9, FGFR3, PTHLH, TGFB2
2MP:00053808.0BMP2, BMPR1B, E2F1, EXT1, EXT2, TGFB2
3MP:00053917.8BMPR1B, E2F1, EXT1, FGF9, FGFR3, PTHLH
4MP:00053717.7BMP2, BMPR1B, EXT1, FGF9, FGFR3, PTHLH
5MP:00053827.4BMP2, BMPR1B, EXT1, FGF9, FGFR3, PTHLH
6MP:00036317.3BMP2, BMPR1B, E2F1, EXT1, FGFR3, PTHLH
7MP:00053897.3BMP2, BMPR1B, E2F1, FGF9, FGFR3, PTHLH
8MP:00053817.3BMP2, E2F1, EXT1, FGF9, FGFR3, PTHLH
9MP:00053777.1BMP2, E2F1, EXT1, FGF9, FGFR3, TGFB2
10MP:00053846.9BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR3
11MP:00053786.6BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR3
12MP:00107686.4BMP2, BMPR1B, E2F1, EXT1, EXT2, FGF9
13MP:00053906.4BMP2, BMPR1B, E2F1, EXT1, EXT2, FGF9

Publications for Osteochondroma

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Articles related to Osteochondroma:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Chondromyxoid fibroma of the finger. (24883287)
2014
2
Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. (24852165)
2014
3
Cloacal exstrophy with extensive Chiari II malformation: case report and review of the literature. (23760474)
2013
4
Age-related macular degeneration and DNA methylation. (23750638)
2013
5
Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. (22606236)
2012
6
Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking. (21216565)
2011
7
Generation of a high-affinity Fcgamma receptor by Ig-domain swapping between human CD64A and CD16A. (20150179)
2010
8
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
9
Stripy Ftz target genes are coordinately regulated by Ftz-F1. (19679121)
2009
10
Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoid. (19769839)
2009
11
Soluble CD26 levels and its association to epidemiologic parameters in a sample population. (20075514)
2009
12
The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts. (18616692)
2008
13
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (18593464)
2008
14
Cognitive approach to the assessment of limb apraxia. (17853141)
2008
15
A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. (17440689)
2007
16
Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. (17549505)
2007
17
Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. (17094378)
2006
18
Dermacase. Chronic venous insufficiency. (17279179)
2006
19
Interventions for infantile esotropia. (15674970)
2005
20
Genital herpes. (16620476)
2005
21
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia. (15711182)
2005
22
Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. (16256791)
2005
23
Bronchiectasis worsening by p-ANCA (bactericidal/permeability-increasing protein) positive vasculitis. A case report and review of the literature]. (16610259)
2005
24
Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. (15111323)
2004
25
Correction of intraoperative coagulopathy in a patient with neurofibromatosis type I with intravenous desmopressin (DDAVP). (15321397)
2004
26
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. (14982997)
2004
27
Mechanics of cell spreading: role of myosin II. (12640045)
2003
28
Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. (12767509)
2003
29
Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay. (12766968)
2003
30
Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway. (12435809)
2002
31
Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study. (11731429)
2001
32
Classification scheme for genes expressed during formation and progression of the avian primitive streak. (11169917)
2001
33
The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway. (10653634)
2000
34
Secreted cathepsin L generates endostatin from collagen XVIII. (10716919)
2000
35
Recent advances in statins and the kidney. (10412725)
1999
36
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study. (9923556)
1999
37
Activin A induces terminal differentiation of cultured human keratinocytes. (10201525)
1999
38
Site-specific synthesis of aflatoxin B(1) adducts within an oligodeoxyribonucleotide containing the human p53 codon 249 sequence. (10458704)
1999
39
Phase II study of a combination of low-dose cisplatin with 13-cis-retinoic acid and interferon-alpha in patients with advanced head and neck squamous cell carcinoma. (10378671)
1999
40
High-dose chemotherapy with BUCY or BEAC and unpurged peripheral blood stem cell infusion in patients with low-grade non-Hodgkin's lymphoma. (9509973)
1998
41
Ossifying fibromyxoid tumor of soft parts: a report of 17 cases with emphasis on unusual histological features. (9869828)
1997
42
Malignant peripheral nerve sheath tumor: a fine-needle aspiration biopsy study. (9316788)
1997
43
The interaction of fluvastatin and cyclosporin A in renal transplant patients. (7620696)
1995
44
CD44 expression in Merkel cell carcinoma may correlate with risk of metastasis. (7514617)
1994
45
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
46
The diagnosis of hyperinsulinism in a child in the absence of hyperinsulinemia. (3528606)
1986
47
Modulation of urinary bladder function with thyrotropin-releasing hormone in patients with spinal cord injuries during the spinal shock phase. (6410971)
1983
48
Congenital rubella in an Indochinese refugee in Manitoba. (20313556)
1981
49
Post-obstructive diuresis in nephrogenic diabetes insipidus associated with bladder neck obstruction. (423345)
1979
50
Removal of Adult Filariae in Cases of Lymphangitis. (20757322)
1897

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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GO Terms for genes affiliated with Osteochondroma

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Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan biosynthetic processGO:000602410.4EXT1, EXT2
2protein glycosylationGO:000648610.2EXT1, EXT2
3cartilage condensationGO:000150210.2BMPR1B, TGFB2
4signal transduction by protein phosphorylationGO:002301410.0BMPR1B, TGFB2
5phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.0FGF9, FGFR3
6embryonic digestive tract developmentGO:004856610.0FGF9, TGFB2
7positive regulation of cell divisionGO:005178110.0FGF9, TGFB2
8positive regulation of cartilage developmentGO:00610369.9BMP2, BMPR1B
9activation of protein kinase activityGO:00321479.9DUSP19, TGFB2
10cardiac epithelial to mesenchymal transitionGO:00603179.7BMP2, TGFB2
11pathway-restricted SMAD protein phosphorylationGO:00603899.7BMP2, TGFB2
12embryo developmentGO:00097909.6BMP2, TGFB2
13positive regulation of cell differentiationGO:00455979.6BMP2, BMPR1B
14eye developmentGO:00016549.6BMPR1B, FGF9, TGFB2
15endocardial cushion morphogenesisGO:00032039.5BMP2, TGFB2
16positive regulation of ossificationGO:00457789.5BMP2, TGFB2
17epithelial to mesenchymal transitionGO:00018379.5BMP2, TGFB2
18SMAD protein signal transductionGO:00603959.5BMP2, TGFB2
19chondrocyte differentiationGO:00020629.4BMP2, BMPR1B, FGF9
20positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.4BMP2, TGFB2
21growthGO:00400079.4BMP2, TGFB2
22bone mineralizationGO:00302829.2BMP2, FGFR3
23positive regulation of MAPK cascadeGO:00434109.2BMP2, FGF9, FGFR3
24cell-cell signalingGO:00072678.9BMP2, PTHLH, TGFB2
25positive regulation of gene expressionGO:00106288.6BMP2, E2F1, FGF9
26positive regulation of cell proliferationGO:00082848.5FGF9, FGFR3, PTHLH, TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.3EXT1, EXT2
2heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.3EXT1, EXT2
3acetylglucosaminyltransferase activityGO:000837510.2EXT1, EXT2
4glucuronosyltransferase activityGO:00150209.6EXT1, EXT2
5SMAD bindingGO:00463329.3BMP2, BMPR1B

Sources for Osteochondroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet