MCID: OST028
MIFTS: 51

Osteochondroma

Categories: Rare diseases, Genetic diseases, Bone diseases

Aliases & Classifications for Osteochondroma

MalaCards integrated aliases for Osteochondroma:

Name: Osteochondroma 49 28 51
Cartilaginous Exostosis 69

Classifications:



External Ids:

UMLS 69 C0029423

Summaries for Osteochondroma

MalaCards based summary : Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and exostoses, multiple, type i. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

Related Diseases for Osteochondroma

Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 34.1 EXT1 EXT2
2 exostoses, multiple, type i 33.4 EXT1 EXT2
3 dysplasia epiphysealis hemimelica 30.9 EXT1 EXT2
4 chondrosarcoma 30.5 EXT1 EXT2 FGF2 PTHLH
5 muenke syndrome 29.5 EXT1 FGF2 FGF9 FGFR1 FGFR3
6 synovial chondromatosis 29.2 BMP2 FGF2 FGF9 FGFR1 FGFR3
7 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 11.9
8 carpotarsal osteochondromatosis 11.6
9 metachondromatosis 11.5
10 exostoses, multiple, type ii 11.5
11 exostoses, multiple, type iii 10.9
12 potocki-shaffer syndrome 10.9
13 plagiocephaly 10.5 FGFR1 FGFR3
14 osteoglophonic dysplasia 10.4 FGFR1 FGFR3
15 multiple enchondromatosis, maffucci type 10.4 EXT1 EXT2
16 enchondromatosis, multiple, ollier type 10.4 EXT1 EXT2 PTHLH
17 cervicitis 10.4
18 dysembryoplastic neuroepithelial tumor 10.3 NES S100B
19 hydromyelia 10.3 S100B VIM
20 bednar tumor 10.3 S100B VIM
21 primary hepatic neuroendocrine carcinoma 10.3 S100B VIM
22 lacrimoauriculodentodigital syndrome 10.3 FGF9 FGFR1 FGFR3
23 clear cell adenoma 10.3 PTHLH S100B
24 ossifying fibromyxoid tumor 10.3 S100B VIM
25 fibrous meningioma 10.3 S100B VIM
26 extramedullary plasmacytoma 10.2 BCL2 CDKN1A
27 lung squamous cell carcinoma 10.2 FGFR1 FGFR3 PTHLH
28 crouzon syndrome 10.2 FGF2 FGFR1 FGFR3
29 chordoid meningioma 10.2 S100B VIM
30 syringocystadenoma papilliferum 10.2 S100B VIM
31 eccrine porocarcinoma 10.2 S100B VIM
32 exostosis 10.2
33 hereditary multiple exostoses 10.2
34 ependymoblastoma 10.2 NES VIM
35 episodic pain syndrome, familial, 1 10.2
36 benign metastasizing leiomyoma 10.2 BCL2 VIM
37 myxopapillary ependymoma 10.1 S100B VIM
38 optic nerve glioma 10.1 NES S100B VIM
39 ependymoma 10.1 NES S100B VIM
40 neurilemmoma 10.1 NES S100B VIM
41 dermatofibrosarcoma protuberans 10.1 NES S100B VIM
42 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.1
43 thrombosis 10.1
44 hidradenocarcinoma 10.1 BCL2 S100B VIM
45 monophasic synovial sarcoma 10.1 S100B VIM
46 apert syndrome 10.1 FGF2 FGF9 FGFR1 FGFR3
47 astroblastoma 10.0 NES VIM
48 bursitis 10.0
49 tooth ankylosis 10.0 BMP2 PTHLH
50 chondroma 9.9

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to Osteochondroma

Symptoms & Phenotypes for Osteochondroma

GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

25 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.7 E2F1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.7 BMP2 E2F1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.7 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 BMP2 CDKN1A E2F1 FGFR1 BCL2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.7 CDKN1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.7 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.7 BCL2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.7 E2F1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.7 E2F1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.7 FGFR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.7 CDKN1A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.7 FGFR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.7 E2F1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.7 BMP2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.7 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.7 BCL2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.7 BCL2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.7 CDKN1A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.7 BCL2

MGI Mouse Phenotypes related to Osteochondroma:

43 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 BMPR1B BMP2 CDKN1A BCL2 FGF2 FGFR1
2 behavior/neurological MP:0005386 10.35 BCL2 FGF2 FGFR1 FGF9 S100B FGFR3
3 embryo MP:0005380 10.32 BMPR1B BMP2 CDKN1A BCL2 FGFR1 FGF9
4 cardiovascular system MP:0005385 10.3 BCL2 BMP2 FGF2 FGFR1 FGF9 PTHLH
5 growth/size/body region MP:0005378 10.3 BCL2 BMPR1B BMP2 FGF9 FGFR1 PTHLH
6 homeostasis/metabolism MP:0005376 10.3 BCL2 BMP2 FGF2 FGFR1 FGF9 PTHLH
7 mortality/aging MP:0010768 10.3 BMPR1B BMP2 BCL2 FGF2 FGFR1 FGF9
8 craniofacial MP:0005382 10.29 BMP2 CDKN1A BCL2 BMPR1B FGFR3 FGFR1
9 digestive/alimentary MP:0005381 10.28 BMP2 CDKN1A BCL2 FGFR3 FGFR1 FGF9
10 hearing/vestibular/ear MP:0005377 10.25 CDKN1A BMP2 BCL2 FGFR1 FGF9 FGFR3
11 hematopoietic system MP:0005397 10.24 BCL2 BMP2 FGF2 FGFR1 PTHLH FGFR3
12 immune system MP:0005387 10.21 BCL2 BMP2 FGF9 FGFR1 PTHLH FGFR3
13 endocrine/exocrine gland MP:0005379 10.17 BMPR1B BCL2 FGF9 FGFR1 TGFB2 PTHLH
14 integument MP:0010771 10.15 BCL2 FGFR1 FGF9 S100B FGFR3 PTHLH
15 nervous system MP:0003631 10.15 BMPR1B BMP2 BCL2 FGF2 FGFR1 FGFR3
16 limbs/digits/tail MP:0005371 10.13 BMPR1B BMP2 CDKN1A FGFR1 FGF9 FGFR3
17 muscle MP:0005369 10.03 BCL2 FGF2 FGFR1 FGF9 TGFB2 CDKN1A
18 reproductive system MP:0005389 10.03 BMPR1B BMP2 CDKN1A BCL2 FGFR3 FGFR1
19 normal MP:0002873 9.92 BMPR1B BMP2 FGF9 FGFR1 S100B FGFR3
20 neoplasm MP:0002006 9.88 BCL2 FGF2 FGFR3 E2F1 CDKN1A EXT1
21 skeleton MP:0005390 9.73 BMPR1B BMP2 CDKN1A FGFR3 FGFR1 FGF9
22 respiratory system MP:0005388 9.7 FGF9 PTHLH FGFR3 TGFB2 CDKN1A E2F1
23 vision/eye MP:0005391 9.4 CDKN1A BCL2 BMPR1B FGFR1 FGF9 FGFR3

Drugs & Therapeutics for Osteochondroma

Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3 Analgesics Phase 4
4 Central Nervous System Depressants Phase 4
5 Narcotics Phase 4
6 Cyclooxygenase 2 Inhibitors Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Analgesics, Opioid Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Antirheumatic Agents Phase 4

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4 etoricoxib;tramadol
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
5 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
6 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Not yet recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
7 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
8 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393
9 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
10 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
11 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
12 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
13 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
14 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
15 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

Genetic tests related to Osteochondroma:

# Genetic test Affiliating Genes
1 Osteochondroma 28

Anatomical Context for Osteochondroma

MalaCards organs/tissues related to Osteochondroma:

38
Bone, Spinal Cord, Testes, Tongue, Appendix, Uterus, Liver

Publications for Osteochondroma

Articles related to Osteochondroma:

(show top 50) (show all 738)
# Title Authors Year
1
Rare Osteochondroma Associated with Natural Mortality of a Wild White-Tailed Deer ( Odocoileus virginianus). ( 29369726 )
2018
2
A multidisciplinary approach for the treatment of young patients with suprasellar osteochondroma. ( 29067502 )
2018
3
Solitary Osteochondroma Presenting as a Dumbbell Tumor Compressing the Cervical Spinal Cord. ( 29017306 )
2017
4
Osteochondroma of maxillary sinus, an unusual location. ( 28802732 )
2017
5
Osteosarcoma in the coracoid process that mimicked an osteochondroma: A case report. ( 29145279 )
2017
6
Oldest epiphyseal osteochondroma in a subadult from Ancient Egypt. ( 28878530 )
2017
7
One-stage surgical excision of a huge bilateral multiple osteochondroma of the hip: a case report. ( 29038715 )
2017
8
Buttock Pain and Sciatica Caused by a Femoral Osteochondroma. ( 28566052 )
2017
9
Surgical Hip Dislocation for Management of Acetabular Osteochondroma in an Adult. ( 28811949 )
2017
10
Osteochondroma and Spinal Cord Compression in a Patient With Hereditary Multiple Exostoses: A Case Report. ( 28228700 )
2017
11
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. ( 28082852 )
2017
12
Extraskeletal osteochondroma within the iliopsoas muscle: case report. ( 28905738 )
2017
13
Giant extraskeletal osteochondroma of foot. A case report with review of literature. ( 29339847 )
2017
14
Exophytic Osteochondroma of the Brow. ( 28614150 )
2017
15
Osteochondroma: Review of 431 patients from one medical institution in South China. ( 28932679 )
2017
16
Teaching NeuroImages: Osteochondroma arising from the clavicle causing ipsilateral Horner syndrome. ( 28696938 )
2017
17
Dentofacial Deformity Caused by Bulky Osteochondroma: Report of an Unusual Case and the Importance of Cone Beam Computed Tomography. ( 28553413 )
2017
18
Parosteal Osteosarcoma of the Distal Radius Mimicking an Osteochondroma-A Diagnostic Misadventure. ( 28917546 )
2017
19
Thoracic spinal osteochondroma: A rare presentation of spinal cord compression. ( 28577449 )
2017
20
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. ( 27777159 )
2017
21
Joint Capsule-Like Intracranial Osteochondroma Mimicking Cystic Meningioma. ( 28882712 )
2017
22
An unusually large osteochondroma of the mandibular angle: a case report. ( 29132383 )
2017
23
Osteochondroma of the Hyoid: First Pediatric Case and Literature Review. ( 28728426 )
2017
24
Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses. ( 29120519 )
2017
25
An Unusual Location of Osteochondroma: Temporal Bone. ( 28962093 )
2017
26
Type IV popliteal arterial entrapment associated with an osteochondroma. ( 29349380 )
2017
27
Identification of a novel mutation in the EXT1 gene from a patient with multiple osteochondromas by exome sequencing. ( 28035357 )
2017
28
Differences in molecular regulation between osteochondroma and bizarre parosteal osteochondromatous proliferation. ( 28560436 )
2017
29
Identification of a new mutation in an Iranian family with hereditary multiple osteochondromas. ( 28053536 )
2017
30
[Analysis of a multiple osteochondroma case caused by novel splice mutation (c.1164+1G to A) of EXT1 gene]. ( 28604967 )
2017
31
The unusual osteochondroma: A case of snapping scapula syndrome and review of the literature. ( 28965995 )
2017
32
Popliteal Artery Pseudoaneurysm Associated with Osteochondroma. ( 29147156 )
2017
33
Excision of Solitary Osteochondroma on the Ventral Aspect of Left Scapula Presenting as Pseudowinging in a 4-year-old Boy: A Rare Case Report. ( 28630837 )
2017
34
Dysplasia epiphysealis hemimelica: a histological comparative study with osteochondromas. ( 28828057 )
2017
35
Osteochondroma of the Cuboid: A Case Report. ( 29079239 )
2017
36
Transpedicular excision of a thoracic intraspinal osteochondroma in a patient with Hereditary Multiple Exostoses and Brown-Sequard syndrome: a case report. ( 29258931 )
2017
37
Secondary Chondrosarcoma from an Osteochondroma of the Proximal Tibia Involving the Fibula. ( 28567230 )
2017
38
Surgical excision of osteochondroma on mandibular condyle via preauricular approach with zygomatic arch osteotomy. ( 29109944 )
2017
39
Intra-articular osteochondroma of the posteroinferior femoral neck associated with hip joint osteochondromatosis: A case report. ( 29181188 )
2017
40
Isolated acetabular osteochondroma of the hip. ( 28869065 )
2017
41
Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice. ( 28445472 )
2017
42
From ideal occlusion to dentofacial deformity and back to ideal: an osteochondroma treatment with lingual orthodontics. ( 28881172 )
2017
43
Non Traumatic Fracture of Pedunculated Osteochondroma: Conservative Management of a Rare Case. ( 29207794 )
2017
44
An Unusual Presentation of Osteochondroma in a Sexagenarian. ( 29375954 )
2017
45
Pes Anserinus Syndrome Caused by Osteochondroma in Paediatrics: A Case Series Study. ( 28603571 )
2017
46
Diode laser ablation of a tracheal osteochondroma in a dog. ( 27112714 )
2016
47
Osteochondroma of the Radial Tuberosity in Child. ( 27454513 )
2016
48
Cervical myelopathy due to a solitary osteochondroma: a case report. ( 27186499 )
2016
49
Extensive Osteochondroma of Talus Presenting as Tarsal Tunnel Syndrome: Report of a case and Literature Review. ( 27517075 )
2016
50
Osteochondroma Complicated by a Popliteal Vein Aneurysm- A Rare Case Report. ( 27790548 )
2016

Variations for Osteochondroma

Expression for Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for Osteochondroma

Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 BCL2 BMP2 BMPR1B CDKN1A E2F1 FGF2
2
Show member pathways
13.67 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
3
Show member pathways
13.49 BCL2 BMP2 CDKN1A FGF2 FGF9 FGFR1
4
Show member pathways
13.31 BCL2 CDKN1A FGF2 FGF9 FGFR1 FGFR3
5
Show member pathways
13.31 BCL2 BMP2 BMPR1B CDKN1A FGF2 FGFR1
6
Show member pathways
13.22 BMP2 FGF2 FGFR1 FGFR3 TGFB2 VIM
7
Show member pathways
13.22 BCL2 BMP2 BMPR1B FGF2 FGFR1 FGFR3
8
Show member pathways
12.82 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
9
Show member pathways
12.81 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
10 12.71 FGF2 FGF9 FGFR1 FGFR3 TGFB2
11
Show member pathways
12.67 CDKN1A FGF2 FGF9 FGFR1 FGFR3
12
Show member pathways
12.63 BMP2 FGF2 FGFR1 FGFR3 TGFB2
13
Show member pathways
12.51 FGF2 FGF9 FGFR1 FGFR3
14
Show member pathways
12.49 BCL2 CDKN1A E2F1 FGF2 TGFB2
15
Show member pathways
12.47 EXT1 EXT2 FGFR1 PTHLH
16
Show member pathways
12.47 BCL2 CDKN1A E2F1 FGF2 FGF9 FGFR1
17
Show member pathways
12.4 FGF2 FGF9 FGFR1 FGFR3
18
Show member pathways
12.4 BCL2 BMPR1B FGFR1 FGFR3
19
Show member pathways
12.37 BMP2 BMPR1B E2F1 FGF2 TGFB2
20
Show member pathways
12.36 FGF2 FGF9 FGFR1 FGFR3
21
Show member pathways
12.35 FGF2 FGF9 FGFR1 FGFR3
22 12.33 BCL2 BMP2 CDKN1A E2F1 FGF2 FGF9
23 12.32 BCL2 CDKN1A E2F1 FGFR3 TGFB2 VIM
24 12.25 CDKN1A FGF2 FGFR1 TGFB2
25
Show member pathways
12.22 FGF2 FGF9 FGFR1 FGFR3
26
Show member pathways
12.13 BCL2 CDKN1A E2F1 FGFR1 FGFR3
27
Show member pathways
12.09 FGF2 FGF9 FGFR1 FGFR3
28 12.01 BMPR1B FGF2 FGFR1 FGFR3
29 11.91 BCL2 BMP2 CDKN1A E2F1 TGFB2
30 11.89 BCL2 CDKN1A FGF2 VIM
31 11.87 FGF2 FGFR1 FGFR3
32 11.84 BMP2 FGF2 TGFB2
33 11.82 BCL2 CDKN1A E2F1
34 11.82 BCL2 BMP2 CDKN1A E2F1
35
Show member pathways
11.81 FGF2 FGF9 FGFR1
36 11.77 BMP2 BMPR1B TGFB2
37 11.72 FGF2 FGFR1 FGFR3 TGFB2
38 11.7 CDKN1A E2F1 FGFR3
39
Show member pathways
11.56 FGF2 FGF9 FGFR3
40 11.47 FGF2 FGFR1 TGFB2
41 11.44 BCL2 CDKN1A E2F1
42 11.38 FGF2 FGFR1 FGFR3
43 11.37 FGF2 FGFR1 FGFR3 PTHLH TGFB2
44 11.06 BMP2 FGF2 FGFR1 FGFR3 NES S100B
45 10.85 BCL2 BMP2 FGF2 FGFR1 FGFR3 TGFB2

GO Terms for Osteochondroma

Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 BCL2 BMP2 CDKN1A PTHLH TGFB2
2 MAPK cascade GO:0000165 9.96 FGF2 FGF9 FGFR1 FGFR3
3 angiogenesis GO:0001525 9.93 FGF2 FGF9 FGFR1 TGFB2
4 negative regulation of gene expression GO:0010629 9.92 BMP2 CDKN1A FGFR1 TGFB2
5 cell-cell signaling GO:0007267 9.89 BMP2 FGF9 FGFR3 PTHLH TGFB2
6 negative regulation of cell growth GO:0030308 9.88 BCL2 CDKN1A TGFB2
7 animal organ morphogenesis GO:0009887 9.87 BCL2 BMP2 FGF2
8 cellular response to hypoxia GO:0071456 9.87 BCL2 E2F1 S100B
9 peptidyl-tyrosine phosphorylation GO:0018108 9.87 FGF2 FGF9 FGFR1 FGFR3
10 male gonad development GO:0008584 9.85 BCL2 FGF9 TGFB2
11 BMP signaling pathway GO:0030509 9.84 BMP2 BMPR1B TGFB2
12 positive regulation of protein kinase B signaling GO:0051897 9.84 FGF2 FGF9 FGFR1 FGFR3
13 response to glucocorticoid GO:0051384 9.79 BCL2 CDKN1A S100B
14 SMAD protein signal transduction GO:0060395 9.77 BMP2 TGFB2 VIM
15 embryonic limb morphogenesis GO:0030326 9.76 FGF9 FGFR1 TGFB2
16 positive regulation of cell proliferation GO:0008284 9.76 BCL2 FGF2 FGF9 FGFR1 FGFR3 PTHLH
17 positive regulation of cell division GO:0051781 9.73 FGF2 FGF9 TGFB2
18 phosphatidylinositol phosphorylation GO:0046854 9.73 FGF2 FGF9 FGFR1 FGFR3
19 branching involved in ureteric bud morphogenesis GO:0001658 9.72 BCL2 BMP2 FGF2
20 ossification GO:0001503 9.71 BCL2 BMP2 EXT1 EXT2
21 embryonic digestive tract development GO:0048566 9.7 FGF9 TGFB2
22 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.69 EXT1 EXT2
23 positive regulation of cardiac muscle cell proliferation GO:0060045 9.69 FGF2 FGF9 FGFR1
24 positive regulation of cartilage development GO:0061036 9.68 BMP2 BMPR1B
25 endocardial cushion morphogenesis GO:0003203 9.68 BMP2 TGFB2
26 positive regulation of ossification GO:0045778 9.68 BMP2 TGFB2
27 pathway-restricted SMAD protein phosphorylation GO:0060389 9.67 BMP2 TGFB2
28 cardiac epithelial to mesenchymal transition GO:0060317 9.67 BMP2 TGFB2
29 generation of neurons GO:0048699 9.67 FGFR1 TGFB2
30 fibroblast growth factor receptor signaling pathway GO:0008543 9.67 FGF2 FGF9 FGFR1 FGFR3
31 atrioventricular valve morphogenesis GO:0003181 9.65 BMP2 TGFB2
32 salivary gland morphogenesis GO:0007435 9.65 FGFR1 TGFB2
33 mesenchymal cell differentiation GO:0048762 9.65 BMP2 FGFR1
34 eye development GO:0001654 9.65 BMPR1B FGF9 TGFB2
35 positive regulation of MAPK cascade GO:0043410 9.65 BMP2 DUSP19 FGF9 FGFR1 FGFR3
36 stem cell proliferation GO:0072089 9.64 FGF2 NES
37 positive regulation of phospholipase C activity GO:0010863 9.64 FGF2 FGFR1
38 positive regulation of phospholipase activity GO:0010518 9.63 FGFR1 FGFR3
39 lung-associated mesenchyme development GO:0060484 9.62 FGF9 FGFR1
40 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.62 FGF2 FGF9 FGFR1 FGFR3
41 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.58 EXT1 EXT2
42 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.52 FGF2 FGFR1
43 cellular polysaccharide biosynthetic process GO:0033692 9.46 EXT1 EXT2
44 chondrocyte differentiation GO:0002062 9.35 BMP2 BMPR1B FGF9 FGFR1 FGFR3
45 skeletal system development GO:0001501 9.17 BMP2 BMPR1B EXT1 FGFR1 FGFR3 PTHLH
46 protein phosphorylation GO:0006468 10.09 BMP2 BMPR1B FGFR1 FGFR3 TGFB2
47 regulation of receptor activity GO:0010469 10 BMP2 FGF2 FGF9 PTHLH TGFB2

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.97 BCL2 EXT1 EXT2 FGFR1 S100B TGFB2
2 protein heterodimerization activity GO:0046982 9.91 BCL2 BMP2 EXT1 EXT2 TGFB2
3 growth factor activity GO:0008083 9.76 BMP2 FGF2 FGF9 TGFB2
4 protein tyrosine kinase activity GO:0004713 9.73 FGF2 FGF9 FGFR1 FGFR3
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.56 FGF2 FGF9 FGFR1 FGFR3
6 fibroblast growth factor-activated receptor activity GO:0005007 9.48 FGFR1 FGFR3
7 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.4 EXT1 EXT2
8 receptor-receptor interaction GO:0090722 9.37 FGF2 FGFR1
9 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.32 EXT1 EXT2
10 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF2 FGF9 FGFR1 FGFR3
11 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.16 EXT1 EXT2
12 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Osteochondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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