MCID: OST028
MIFTS: 54

Osteochondroma malady

Genetic diseases, Rare diseases, Bone diseases categories
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Summaries for Osteochondroma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards: Osteochondroma, also known as cartilaginous exostosis, is related to hereditary multiple osteochondromas and exostosis. An important gene associated with Osteochondroma is EXT2 (exostosin glycosyltransferase 2), and among its related pathways are heparan sulfate biosynthesis and Signaling events mediated by the Hedgehog family. The compounds pd 161570 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Osteochondroma

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43NIH Rare Diseases, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondroma 43 45
cartilaginous exostosis 62


Related Diseases for Osteochondroma

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17GeneCards, 18GeneDecks
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Diseases in the Hereditary Multiple Osteochondromas family:

osteochondroma

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary multiple osteochondromas31.0EXT1, EXT2
2exostosis30.9EXT1, EXT2
3hereditary multiple exostoses30.8POMGNT2, EXT2, EXT1
4osteosarcoma30.5PTHLH, TGFB2, E2F1, DUSP19, BMP2, EXT1
5chondrosarcoma30.4E2F1, DUSP19, BMP2, EXT2, EXT1, FGFR1
6fibrodysplasia ossificans progressiva30.3BMP2, ACVR1
7muenke syndrome30.2FGFR1, FGFR3
8sarcoma30.1E2F1, NES, BMP2, EXT2, EXT1
9synostosis29.9FGFR1, FGFR3
10keloids29.9TGFB2, FGF2
11adenocarcinoma29.7PTHLH, TGFB2, POMGNT2, E2F1, NES, BMP2
12cervicitis10.6
13dysplasia epiphysealis hemimelica10.3
14metachondromatosis10.3
15chondroma10.2
16bursitis10.2
17enchondroma10.2
18aneurysm10.1
19thanatophoric dysplasia10.1FGFR3
20primary pulmonary hypertension10.1BMP2
21osteoglophonic dysplasia10.1FGFR1
22osteochondrodysplasia10.1PTHLH, FGFR3
23achondroplasia10.1FGF9, FGFR3
24autosomal dominant disease10.1EXT1, EXT2
25seborrheic keratosis10.1TGFB2, FGFR3
26ollier disease10.1PTHLH, EXT2, EXT1
27hypochondroplasia10.1FGFR1, FGFR3
28pilocytic astrocytoma10.1NES
29fgfr-related craniosynostosis syndromes10.1FGFR1, FGFR3
30jackson-weiss syndrome10.1FGFR1, FGFR3
31infectious mononucleosis10.1FGFR3, FGFR1
32osteoporosis, postmenopausal10.1PTHLH, TGFB2
33acrocephalosyndactylia10.1FGFR3, FGFR1
34saethre-chotzen syndrome10.1FGFR1, FGFR3
35malignant peripheral nerve sheath tumor10.1NES, BMP2
36malignant fibroxanthoma10.1BMP2, DUSP19
37bone carcinoma10.1PTHLH, BMP2, EXT2, EXT1
38secondary syphilis10.1EXT1, EXT2, BMP2, PTHLH
39progressive osseous heteroplasia10.0ACVR1, BMP2
40pseudoarthrosis10.0
41osteoblastoma10.0
42brown-sequard syndrome10.0
43quadriplegia10.0
44vertebral artery occlusion10.0
45meningioma10.0
46periostitis10.0
47sleep apnea10.0
48carpotarsal osteochondromatosis10.0
49synovial chondromatosis10.0
50dysphagia10.0

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms for Osteochondroma

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Drugs & Therapeutics for Osteochondroma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Osteochondroma

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Anatomical Context for Osteochondroma

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33MalaCards
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MalaCards organs/tissues related to Osteochondroma:

33
Bone, Spinal cord, Bone marrow, Tongue, Testes, Uterus, Breast, Liver, Lymph node, Appendix

Animal Models for Osteochondroma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Osteochondroma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5FGF9, FGFR3, E2F1, TGFB2, PTHLH
2MP:00028738.2E2F1, BMP2, EXT1, FGFR3, FGF9
3MP:00020068.2E2F1, ACVR1, EXT1, FGF2, FGFR3
4MP:00107718.1PTHLH, E2F1, EXT1, FGFR1, FGFR3, FGF9
5MP:00053798.1PTHLH, TGFB2, E2F1, BMPR1B, FGFR1, FGF9
6MP:00053717.9PTHLH, TGFB2, ACVR1, BMPR1B, BMP2, EXT1
7MP:00053697.9TGFB2, E2F1, ACVR1, FGFR1, FGF2, FGF9
8MP:00053827.9PTHLH, TGFB2, ACVR1, BMPR1B, BMP2, EXT1
9MP:00053817.5PTHLH, TGFB2, E2F1, ACVR1, BMP2, EXT1
10MP:00053897.5PTHLH, TGFB2, E2F1, BMPR1B, BMP2, FGF2
11MP:00053857.4PTHLH, TGFB2, E2F1, ACVR1, BMP2, FGFR1
12MP:00053767.4PTHLH, TGFB2, E2F1, ACVR1, BMP2, FGF2
13MP:00053777.3TGFB2, E2F1, ACVR1, BMP2, EXT1, FGFR1
14MP:00053807.3TGFB2, E2F1, NES, ACVR1, BMPR1B, BMP2
15MP:00053917.2PTHLH, TGFB2, E2F1, BMPR1B, EXT1, FGFR1
16MP:00053867.1PTHLH, E2F1, NES, ACVR1, EXT1, FGFR1
17MP:00053786.7NES, E2F1, TGFB2, PTHLH, ACVR1, BMPR1B
18MP:00036316.5PTHLH, TGFB2, E2F1, NES, ACVR1, BMPR1B
19MP:00053906.3FGF9, PTHLH, TGFB2, E2F1, ACVR1, BMPR1B
20MP:00053846.2ACVR1, NES, E2F1, TGFB2, PTHLH, BMPR1B
21MP:00107686.0ACVR1, NES, E2F1, TGFB2, PTHLH, BMPR1B

Publications for Osteochondroma

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52PubMed
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Articles related to Osteochondroma:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Letter regarding "Effect of osteochondroma location on forearm deformity in patients with multiple hereditary osteochondromatosis". (23790427)
2013
2
Transformation of solitary osteochondroma to dedifferentiated chondrosarcoma arising in the distal radius: a case report. (23007379)
2013
3
Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas. (23412166)
2013
4
Osteochondroma of mandibular condyle: A clinic-radiographic correlation. (24082753)
2013
5
Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency. (23384194)
2013
6
Solitary osteochondroma arising from cervical spina bifida occulta. (24383028)
2013
7
Osteochondroma as a cause of scapular winging in an adolescent: a case report and review of the literature. (23971723)
2013
8
Giant costal osteochondroma in a man with multiple exostoses. (23910108)
2013
9
Osteochondroma of the temporomandibular joint: report of 2 cases emphasizing the importance of personalizing the surgical treatment. (22669156)
2012
10
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (22246151)
2012
11
Isolated osteochondroma of the femoral neck presenting as hip and leg pain. A case study. (22619103)
2012
12
Malignant degeneration of a lumbar osteochondroma into a chondrosarcoma which mimicked a large retropertioneal mass. (22526879)
2012
13
3-D printout of a DICOM file to aid surgical planning in a 6 year old patient with a large scapular osteochondroma complicating congenital diaphyseal aclasia. (22690278)
2012
14
A synovial osteochondroma replacing the anterior cruciate ligament at the intercondylar notch. (21323282)
2011
15
Computer-assisted surgical planning and simulation for condylar reconstruction in patients with osteochondroma. (20427106)
2011
16
Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. (21506131)
2011
17
Spinal cord compression secondary to a thoracic vertebral osteochondroma. (21599443)
2011
18
Scapular osteochondroma treated with arthroscopic excision using prone positioning. (20396684)
2010
19
Cervical spine osteochondroma: rare presentation of a common lesion. (21109061)
2010
20
Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. (20012156)
2010
21
A rare anterior sacral osteochondroma presenting as sciatica in an adult: a case report and review of the literature. (20421072)
2010
22
Resected osteochondroma of the rib in an elderly patient. (21069500)
2010
23
Osteochondroma of the talus. (20632929)
2010
24
A multilobed osteochondroma of the hamate: case report. (19695798)
2009
25
Osteochondroma of the mandibular condyle: Resection and reconstruction using vertical sliding osteotomy of the mandibular ramus. (19333189)
2009
26
Concurrent osteochondroma and osteoblastoma of the proximal humeral shaft. (19226029)
2009
27
Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. (18196252)
2008
28
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. (17301954)
2007
29
Phalangeal osteochondroma. (17323627)
2007
30
Discomfort during sexual intercourse secondary to osteochondroma: a report of two cases. (17588798)
2007
31
Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. (17226760)
2007
32
Osteochondroma of the skull base. (17599588)
2007
33
An optimized DHPLC protocol for molecular testing of the EXT1 and EXT2 genes in hereditary multiple osteochondromas. (16283885)
2005
34
Subungual osteochondroma: clinical and radiologic features and treatment. (15209794)
2004
35
A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica? (14564279)
2003
36
Extraskeletal osteochondroma of the buttock. (12589103)
2003
37
Condylar osteochondroma with complete hearing loss: report of a case. (12524621)
2003
38
Arterial compromise caused by lower limb osteochondroma. (12799727)
2003
39
Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage. (12472121)
2002
40
Osteochondroma of the posterior nasal septum managed by endoscopic transnasal transseptal approach. (12487678)
2002
41
Two cases of osteochondroma recurrence after surgical resection. (11198832)
2001
42
Osteochondroma of the C5 lamina with cord compression: case report and review of the literature. (10806510)
2000
43
Cervical myelopathy due to an osteochondroma in a 73-year-old female. The oldest case in the literature. (10983260)
2000
44
Osteochondroma of the tracheal wall in a Fischer's lovebird (Agapornis fischeri, Reichenow 1887). (10216774)
1999
45
Scaphoid osteochondroma. (9457602)
1997
46
Dysplasia epiphysealis hemimelica. Upper limb involvement with associated osteochondroma. (7924021)
1994
47
Cervical osteochondroma (C2 level) with vertebral artery occlusion and second cervical nerve root irritation. (2718087)
1989
48
Osteochondroma with thoracic cord compression in hereditary multiple exostoses: a case report. (312508)
1979
49
Osteochondroma of the cervical spine: a cause of transient quadriplegia. (460559)
1979
50
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. (5803809)
1969

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondroma

Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 51PharmGKB, 57SinoBiological, 60Thomson Reuters, 54R&D Systems, 61Tocris Bioscience
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Pathways related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
heparan sulfate biosynthesis (late stages)38
10.0EXT1, EXT2
29.9TGFB2, PTHLH
39.8BMP2, BMPR1B
49.6FGF2, FGFR1
59.5TGFB2, BMPR1B, BMP2
6
Show member pathways
9.3BMP2, BMPR1B, ACVR1
79.3FGFR3, FGF2, FGFR1
89.3FGFR3, FGF2, FGFR1
9
Show member pathways
9.3FGFR3, FGF2, FGFR1
109.3TGFB2, FGFR1, FGF2
11
Show member pathways
9.0BMP2, BMPR1B, ACVR1, TGFB2
129.0TGFB2, ACVR1, BMPR1B, BMP2
139.0FGFR3, FGFR1, E2F1
149.0TGFB2, FGFR1, FGF2, FGFR3
15
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
16
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
17
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
189.0FGFR1, FGF2, FGFR3, FGF9
19
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
20
Show member pathways
9.0FGFR1, FGF2, FGFR3, FGF9
21
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
22
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
23
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
24
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
25
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
26
Show member pathways
9.0FGF9, FGFR3, FGF2, FGFR1
279.0TGFB2, FGFR1, FGF2, FGF9
28
Show member pathways
9.0ACVR1, BMPR1B, FGFR1, FGFR3
298.8E2F1, FGFR1, FGF2
308.8PTHLH, TGFB2, FGFR1, FGF2, FGFR3
31
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
32
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
33
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
34
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
35
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
36
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
37
Show member pathways
8.7TGFB2, BMP2, FGFR1, FGF2, FGFR3
38
Show member pathways
MAPK signaling pathway38
8.7TGFB2, FGFR1, FGF2, FGFR3, FGF9
398.5EXT2, EXT1, FGFR1, FGF2, FGFR3, FGF9
40
Show member pathways
8.4TGFB2, BMP2, FGFR1, FGF2, FGFR3, FGF9
41
Show member pathways
8.4TGFB2, ACVR1, BMPR1B, BMP2, FGFR1, FGFR3
42
Show member pathways
8.2E2F1, FGFR1, FGF2, FGFR3, FGF9
43
Show member pathways
Signaling Pathways in Glioblastoma38
8.2E2F1, FGFR1, FGF2, FGFR3, FGF9
44
Show member pathways
7.9FGF2, FGFR1, BMP2, BMPR1B, ACVR1, TGFB2
45
Show member pathways
7.9TGFB2, FGFR3, FGF2, FGFR1, BMP2, BMPR1B
46
Show member pathways
7.7TGFB2, E2F1, ACVR1, BMPR1B, BMP2, FGF2
47
Show member pathways
7.6TGFB2, E2F1, BMP2, FGFR1, FGF2, FGFR3
487.6FGF9, TGFB2, E2F1, BMP2, FGFR1, FGF2
49
Show member pathways
7.2PTHLH, E2F1, BMPR1B, BMP2, FGFR1, FGF2
50
Show member pathways
7.0TGFB2, E2F1, ACVR1, BMPR1B, BMP2, FGFR1

Compounds for genes affiliated with Osteochondroma

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1pd 1615706110.1FGFR1, FGFR3
2fiin 1 hydrochloride6110.0FGFR1, FGFR3
3su 54026110.0FGFR1, FGFR3
4palifermin45 1110.8FGFR3, FGFR1
5su5402459.7FGFR3, FGF2, FGFR1
6pd 17307445 6110.7FGFR1, FGF2, FGFR3
7su6668459.7FGF2, FGFR1
8alginate459.7FGF2, BMP2, TGFB2
9glycosaminoglycan459.5TGFB2, BMP2, EXT1, FGF2
10dihydrotestosterone45 29 24 1112.5PTHLH, TGFB2, BMP2, FGF2
11ribonucleic acid459.5FGFR1, BMP2, TGFB2, PTHLH
12calcitriol45 61 24 1112.4PTHLH, TGFB2, BMP2, FGF2
13paraffin459.2PTHLH, TGFB2, NES, FGF2, FGFR3
14nicotine45 29 51 1112.1PTHLH, DUSP19, BMP2, FGF2
15chondroitin sulfate45 2410.1FGF2, FGFR1, POMGNT2
16forskolin45 51 1111.0PTHLH, TGFB2, DUSP19, BMP2, FGFR1
17matrigel458.9PTHLH, TGFB2, NES, BMP2, FGF2, FGF9
18dopamine45 29 24 1111.9TGFB2, DUSP19, NES, BMP2, FGFR1
19pge2458.9PTHLH, TGFB2, DUSP19, BMP2, FGF2
20lysine458.8PTHLH, E2F1, BMP2, FGFR1, FGFR3
21tgf beta1458.7PTHLH, TGFB2, E2F1, BMP2, FGF2
22genistein45 29 61 3 24 1113.7TGFB2, DUSP19, BMP2, FGFR1, FGF2
23agar458.6PTHLH, TGFB2, E2F1, FGFR1, FGF2
24dexamethasone45 51 29 1111.6PTHLH, TGFB2, DUSP19, BMP2, FGF2, FGFR3
25testosterone45 61 24 1111.6PTHLH, TGFB2, E2F1, BMP2, FGFR1
26polysaccharide458.6POMGNT2, DUSP19, BMP2, FGFR1, FGF2
27tetracycline45 119.6FGF2, BMP2, E2F1
28steroid458.5PTHLH, TGFB2, E2F1, BMP2, FGFR1
29progesterone45 29 61 24 1112.5PTHLH, TGFB2, E2F1, NES, BMP2, FGFR1
30heparan sulfate45 249.5FGF2, PTHLH, POMGNT2, BMP2, EXT2, EXT1
31nitric oxide45 24 1110.5PTHLH, TGFB2, E2F1, NES, BMP2, FGFR1
32oligonucleotide458.4TGFB2, E2F1, ACVR1, BMP2, FGFR1, FGFR3
33thymidine45 249.4PTHLH, TGFB2, E2F1, BMP2, FGFR1, FGF2
34cysteine458.4TGFB2, POMGNT2, DUSP19, BMP2, FGFR1, FGFR3
35ascorbic acid45 249.3TGFB2, E2F1, DUSP19, BMP2, FGF2
36bromodeoxyuridine458.3PTHLH, TGFB2, E2F1, NES, FGFR1, FGF2
37paclitaxel45 51 1110.3FGF2, FGFR1, DUSP19, E2F1, PTHLH
38threonine458.2PTHLH, DUSP19, ACVR1, BMPR1B, BMP2, FGFR1
39rapamycin458.1POMGNT2, E2F1, DUSP19, BMP2
40heparin45 29 24 1111.1PTHLH, TGFB2, POMGNT2, BMP2, EXT1, FGFR1
41cycloheximide458.1PTHLH, TGFB2, E2F1, DUSP19, BMP2, FGF2
42glutamate458.1TGFB2, E2F1, DUSP19, NES, FGFR1, FGFR3
43phosphatidylinositol458.0PTHLH, TGFB2, E2F1, DUSP19, FGFR1, FGF2
44calcium45 51 24 1111.0PTHLH, TGFB2, DUSP19, ACVR1, BMP2, FGFR1
45lipid457.9PTHLH, E2F1, DUSP19, NES, BMP2, FGFR1
46vegf457.4PTHLH, TGFB2, E2F1, NES, BMP2, FGFR1
47estrogen457.1PTHLH, TGFB2, E2F1, DUSP19, NES, BMP2
48retinoic acid45 247.9PTHLH, TGFB2, POMGNT2, E2F1, DUSP19, NES
49tyrosine456.4PTHLH, TGFB2, E2F1, DUSP19, NES, BMPR1B
50serine456.1PTHLH, TGFB2, POMGNT2, E2F1, DUSP19, ACVR1

GO Terms for genes affiliated with Osteochondroma

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16Gene Ontology
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Cellular components related to Osteochondroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.2FGFR3, EXT1, EXT2, POMGNT2
2extracellular spaceGO:0056158.5PTHLH, TGFB2, BMP2, FGF2, FGF9
3extracellular regionGO:0055768.1FGF9, FGFR3, FGF2, FGFR1, BMP2, TGFB2

Biological processes related to Osteochondroma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:03369210.4EXT2, EXT1
2heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:01501410.4EXT2, EXT1
3heparan sulfate proteoglycan biosynthetic processGO:01501210.3EXT2, EXT1
4cardiac epithelial to mesenchymal transitionGO:06031710.2BMP2, TGFB2
5positive regulation of ossificationGO:04577810.2BMP2, TGFB2
6mesenchymal cell differentiationGO:04876210.2BMP2, FGFR1
7endoderm developmentGO:00749210.2EXT1, PTHLH
8positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.2FGFR1, FGFR3
9positive regulation of phospholipase activityGO:01051810.2FGFR1, FGFR3
10embryonic digestive tract developmentGO:04856610.1FGF9, TGFB2
11lung-associated mesenchyme developmentGO:06048410.1FGF9, FGFR1
12corticotropin hormone secreting cell differentiationGO:06012810.1BMP2, FGF2
13thyroid-stimulating hormone-secreting cell differentiationGO:06012910.1FGF2, BMP2
14positive regulation of epithelial to mesenchymal transitionGO:01071810.0TGFB2, BMP2
15eye developmentGO:00165410.0BMPR1B, TGFB2
16endochondral ossificationGO:00195810.0FGFR3, PTHLH
17cartilage condensationGO:0015029.9TGFB2, BMPR1B
18pathway-restricted SMAD protein phosphorylationGO:0603899.9BMP2, ACVR1, TGFB2
19positive regulation of phospholipase C activityGO:0108639.9FGFR1, FGF2
20organ inductionGO:0017599.9FGF2, FGFR1
21positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.9ACVR1, BMP2
22response to axon injuryGO:0486789.8FGFR3, FGF2
23positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8FGF2, FGFR3
24positive regulation of endothelial cell proliferationGO:0019389.8BMP2, FGF2, FGFR3
25positive regulation of bone mineralizationGO:0305019.8BMP2, BMPR1B, ACVR1
26substantia nigra developmentGO:0217629.8FGF2, FGFR3, FGF9
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGFR3, FGF2, BMP2
28positive regulation of cell divisionGO:0517819.7FGF9, FGF2, TGFB2
29BMP signaling pathwayGO:0305099.7BMP2, BMPR1B, ACVR1
30positive regulation of cell cycleGO:0457879.7FGFR1, TGFB2
31positive regulation of cardiac muscle cell proliferationGO:0600459.7FGF9, FGF2, FGFR1
32cell-cell signalingGO:0072679.5PTHLH, TGFB2, BMP2, FGFR3, FGF9
33angiogenesisGO:0015259.5FGF9, FGFR1, TGFB2
34negative regulation of cell proliferationGO:0082859.5PTHLH, TGFB2, BMP2, FGF2
35positive regulation of cell differentiationGO:0455979.4BMPR1B, FGFR3
36phosphatidylinositol-mediated signalingGO:0480159.4FGF9, FGFR3, FGF2, FGFR1
37insulin receptor signaling pathwayGO:0082869.4FGFR1, FGF2, FGFR3, FGF9
38fibroblast growth factor receptor signaling pathwayGO:0085439.4FGF9, FGFR3, FGF2, FGFR1
39Fc-epsilon receptor signaling pathwayGO:0380959.4FGFR1, FGF2, FGFR3, FGF9
40epidermal growth factor receptor signaling pathwayGO:0071739.4FGF9, FGFR3, FGF2, FGFR1
41neurotrophin TRK receptor signaling pathwayGO:0480119.3FGFR1, FGF2, FGFR3, FGF9
42positive regulation of osteoblast differentiationGO:0456699.3ACVR1, BMPR1B, BMP2, FGF2
43chondrocyte differentiationGO:0020629.2FGF9, FGFR3, FGFR1, BMP2, BMPR1B
44positive regulation of gene expressionGO:0106289.2TGFB2, E2F1, BMP2, FGF9
45protein phosphorylationGO:0064689.1TGFB2, ACVR1, BMPR1B, BMP2, FGFR1
46positive regulation of MAPK cascadeGO:0434109.1DUSP19, BMP2, FGFR1, FGFR3, FGF9
47skeletal system developmentGO:0015019.0PTHLH, BMPR1B, BMP2, EXT1, FGFR1, FGFR3
48positive regulation of cell proliferationGO:0082848.9PTHLH, TGFB2, FGFR1, FGF2, FGFR3, FGF9
49negative regulation of transcription from RNA polymerase II promoterGO:0001228.8E2F1, BMP2, FGFR1, FGFR3, FGF9
50positive regulation of transcription, DNA-templatedGO:0458938.7E2F1, ACVR1, BMP2, FGF2

Molecular functions related to Osteochondroma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:05050910.3EXT2, EXT1
2heparan sulfate N-acetylglucosaminyltransferase activityGO:04232810.3EXT2, EXT1
3glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:05050810.2EXT1, EXT2
4fibroblast growth factor-activated receptor activityGO:00500710.0FGFR1, FGFR3
5transferase activity, transferring glycosyl groupsGO:01675710.0EXT1, EXT2
6glucuronosyltransferase activityGO:01502010.0EXT1, EXT2
7transforming growth factor beta receptor activity, type IGO:0050259.8BMPR1B, ACVR1
8acetylglucosaminyltransferase activityGO:0083759.8EXT1, EXT2, POMGNT2
9transmembrane receptor protein serine/threonine kinase activityGO:0046759.8ACVR1, BMPR1B
10receptor signaling protein serine/threonine kinase activityGO:0047029.6BMPR1B, ACVR1, TGFB2
11fibroblast growth factor bindingGO:0171349.6FGFR1, FGF2, FGFR3
12SMAD bindingGO:0463329.6ACVR1, BMPR1B, BMP2
13protein heterodimerization activityGO:0469829.5EXT1, EXT2, BMP2, TGFB2
14fibroblast growth factor receptor bindingGO:0051049.5FGF9, FGF2
15growth factor activityGO:0080839.3FGF9, FGF2, BMP2, TGFB2
16heparin bindingGO:0082019.3FGFR1, FGF2, FGF9
17cytokine activityGO:0051259.1TGFB2, BMP2, FGF2
18protein homodimerization activityGO:0428039.1FGFR1, EXT1, EXT2, ACVR1, TGFB2

Products for genes affiliated with Osteochondroma

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Sources for Osteochondroma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet