MCID: OST028
MIFTS: 47

Osteochondroma malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Metabolic diseases, Fetal diseases

Aliases & Classifications for Osteochondroma

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Aliases & Descriptions for Osteochondroma:

Name: Osteochondroma 48 27 50
 
Cartilaginous Exostosis 68

Classifications:



Summaries for Osteochondroma

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Wikipedia:71 Osteochondromas or osteocartilaginous exostoses are the most common benign tumors of the bones. The... more...

MalaCards based summary: Osteochondroma, also known as cartilaginous exostosis, is related to trichorhinophalangeal syndrome, type ii and thoracic outlet syndrome. An important gene associated with Osteochondroma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are Neural Crest Differentiation and Signaling by activated point mutants of FGFR3. Affiliated tissues include bone, spinal cord and testes, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and neoplasm.

Related Diseases for Osteochondroma

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Diseases in the Osteochondroma family:

Hereditary Multiple Osteochondromas

Diseases related to Osteochondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1trichorhinophalangeal syndrome, type ii31.9EXT1, EXT2
2thoracic outlet syndrome29.0BCL2, CDKN1A, E2F1
3hereditary multiple osteochondromas12.4
4dysplasia epiphysealis hemimelica with chondromas and osteochondromas11.8
5metachondromatosis11.4
6hereditary multiple exostoses11.1
7carpotarsal osteochondromatosis11.0
8exostoses, multiple, type 110.9
9exostoses, multiple, type 210.9
10potocki-shaffer syndrome10.8
11erythroderma, lethal congenital10.3EXT1, EXT2
12cervicitis10.3
13familial porphyria cutanea tarda10.3FGFR1, FGFR3
14lupus - neurological sequelae10.3S100B, VIM
15macrosomia with microphthalmia, lethal10.2EXT1, EXT2, PTHLH
16malignant adult ependymoma10.2EXT2, PTHLH, VIM
17apert syndrome10.2FGF2, FGFR1, FGFR3
18benign schwannoma10.2S100B, VIM
19hartsfield syndrome10.2FGFR1, FGFR3
20pointer syndrome10.2FGFR1, FGFR3
21central nervous system hemangioma10.1NES, S100B, VIM
22c-p angle neurinoma10.1NES, S100B, VIM
23saddan10.1FGF9, FGFR1, FGFR3
24epimetaphyseal dysplasia cataract10.1NES, S100B, VIM
25jejunal neuroendocrine tumor10.1S100B, VIM
26cutaneous leishmaniasis10.1FGF2, FGFR1, FGFR3
27mental retardation, autosomal recessive 4010.1EXT1, EXT2, FGF2, PTHLH
28neutrophil immunodeficiency syndrome10.1NES, S100B, VIM
29exostosis10.1
30his bundle tachycardia10.1BCL2, S100B, VIM
31chondrosarcoma10.1
32scaphocephaly, maxillary retrusion, and mental retardation10.1FGF2, FGF9, FGFR1, FGFR3
33cecum adenoma10.1BCL2, S100B, VIM
34grade iii astrocytoma10.0FGF2, FGFR1, NES, S100B
35thrombosis10.0
36myoma10.0S100B, VIM
37cervical cancer, somatic10.0EXT1, FGF2, FGF9, FGFR1, FGFR3
38juvenile astrocytoma10.0FGFR1, FGFR3, NES, S100B, VIM
39ischemic bone disease10.0BMP2, EXT1, EXT2
40bursitis10.0
41muscular dystrophy-dystroglycanopathy9.9BMP2, BMPR1B, PTHLH
42tarsal-carpal coalition syndrome9.9BMP2, BMPR1B, FGF9
43binocular vision disease9.9BMP2, PTHLH
44multiple synostoses syndrome9.9BMP2, BMPR1B, FGF9
4513q12.3 microdeletion syndrome9.9BCL2, CDKN1A, FGFR3, PTHLH, VIM
46dysplasia epiphysealis hemimelica9.9
47synovial chondromatosis9.9
48chondroma9.8
49fibrodysplasia ossificans progressiva9.8
50enchondroma9.8

Graphical network of the top 20 diseases related to Osteochondroma:



Diseases related to osteochondroma

Symptoms & Phenotypes for Osteochondroma

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GenomeRNAi Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-847.9BCL2, BMP2, CDKN1A, E2F1, FGFR1

MGI Mouse Phenotypes related to Osteochondroma according to GeneCards Suite gene sharing:

41 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8BCL2, CDKN1A, E2F1, EXT1, FGF2, FGFR3
2MP:00053887.6BCL2, CDKN1A, E2F1, FGF9, FGFR3, PTHLH
3MP:00028737.6BMP2, BMPR1B, E2F1, EXT1, FGF9, FGFR1
4MP:00053697.6BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
5MP:00107717.5BCL2, CDKN1A, E2F1, EXT1, FGF9, FGFR1
6MP:00053797.5BCL2, BMPR1B, CDKN1A, E2F1, FGF9, FGFR1
7MP:00053717.4BMP2, BMPR1B, CDKN1A, EXT1, FGF9, FGFR1
8MP:00053807.3BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
9MP:00053867.2BCL2, CDKN1A, E2F1, EXT1, FGF2, FGF9
10MP:00053827.2BCL2, BMP2, BMPR1B, CDKN1A, EXT1, FGF9
11MP:00053776.7BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF2
12MP:00053916.6BCL2, BMPR1B, CDKN1A, E2F1, EXT1, FGF2
13MP:00053816.6BCL2, BMP2, CDKN1A, E2F1, EXT1, FGF9
14MP:00053976.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGFR1
15MP:00053856.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
16MP:00053906.3BMP2, BMPR1B, CDKN1A, E2F1, EXT1, EXT2
17MP:00053786.3BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
18MP:00053896.1BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2
19MP:00053766.0BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
20MP:00036316.0BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
21MP:00053845.7BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1
22MP:00107685.5BCL2, BMP2, BMPR1B, CDKN1A, E2F1, EXT1

Drugs & Therapeutics for Osteochondroma

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Drugs for Osteochondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etoricoxibapproved, investigationalPhase 493202409-33-4123619
Synonyms:
202409-33-4
5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl
5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-2-(6-Methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
5-chloro-6'-Methyl-3-(P-(methylsulfonyl)phenyl)-2,3'-bipyridine
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
5CH
AC1L3WZM
Algix
Arcoxia
C11718
C422649
CHEBI:106706
CHEBI:6339
CHEMBL416146
CID123619
D03710
DB01628
DB07166
ETORICOXIB
 
Etoricoxib
Etoricoxib (USAN/INN)
Etoricoxib [USAN:INN:BAN]
Etoricoxibe
Etoricoxibum
FT-0082494
HMS2090A05
L-791456
L001141
L791456
LS-181802
MK 0663
MK 663
MK-0663
MK-663
Merck Sharp & Dohme brand of etoricoxib
MolPort-003-847-339
NCGC00164578-01
Nucoxia
Tauxib
UNII-WRX4NFY03R
ZINC00579472
2
Tramadolapproved, investigationalPhase 424127203-92-533741
Synonyms:
(+)-(R,R)-trans-Tramadol
(+)-Tramadol
(+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol
(+)-trans-Tramadol free ba
(1R,2R)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
(1R,2R)-2-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
(1R,2R)-2-[(dimethylamino)methyl]-1-[3-(methyloxy)phenyl]cyclohexanol
27203-92-5
AC1L1Q6E
AC1Q59O2
AKOS005066335
Amanda
Amanda (TN)
BIDD:GT0075
C07153
CHEMBL1066
CID33741
Crispin
D08623
DB00193
EINECS 248-319-6
HMS2090D10
Jsp005295
LS-57115
 
LS-57116
MLS000333190
MolPort-002-507-778
NCGC00159343-02
Ralivia ER
Ralivia Flashtab
Ralivia flashtab
SMR000436547
STOCK4S-19075
Tradonal odis
Tramadol
Tramadol (INN)
Tramadol HCl
Tramadol HCl BP/EP
Tramadol [INN:BAN]
Tramadol hydrochloride
Tramadolum
Tramadolum [INN-Latin]
Tramal
Tramodol Hcl
Tridural
UNII-39J1LGJ30J
Ultram
Ultram ER
Zydol
tramadol
3Cyclooxygenase InhibitorsPhase 42870
4Peripheral Nervous System AgentsPhase 423689
5Cyclooxygenase 2 InhibitorsPhase 4624
6NarcoticsPhase 43646
7Central Nervous System DepressantsPhase 413403
8Analgesics, OpioidPhase 43238
9Analgesics, Non-NarcoticPhase 46501
10Anti-Inflammatory AgentsPhase 410729
11Anti-Inflammatory Agents, Non-SteroidalPhase 44443
12Antirheumatic AgentsPhase 410956
13AnalgesicsPhase 411733

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus TendonUnknown statusNCT01341509Phase 4
2The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus SurgeryCompletedNCT00733421Phase 4
3Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon TransferCompletedNCT00950053Phase 4
4Autologous Stem Cells in Achilles TendinopathyRecruitingNCT02064062Phase 2
5Flexible Footwear and Insole in Heel PainRecruitingNCT03040557Phase 1, Phase 2
6The Health-Related Quality of Life in Patients With Hereditary Multiple ExostosesCompletedNCT00474448
7Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and KneeCompletedNCT01771393
8A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal SpurCompletedNCT01510249
9Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel PainCompletedNCT02895698
10Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar FasciitisCompletedNCT01439932
11The Fibrodysplasia Ossificans Progressiva (FOP) Connection RegistryRecruitingNCT02745158
12Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal SpurRecruitingNCT02934100
13Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre ProjectSuspendedNCT00474331
14Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BCTerminatedNCT00473850

Search NIH Clinical Center for Osteochondroma

Genetic Tests for Osteochondroma

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Genetic tests related to Osteochondroma:

id Genetic test Affiliating Genes
1 Osteochondroma27

Anatomical Context for Osteochondroma

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MalaCards organs/tissues related to Osteochondroma:

36
Bone, Spinal cord, Testes, Tongue, Appendix, Uterus, Liver

Publications for Osteochondroma

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Articles related to Osteochondroma:

(show top 50)    (show all 697)
idTitleAuthorsYear
1
Identification of a novel mutation in the EXT1 gene from a patient with multiple osteochondromas by exome sequencing. (28035357)
2017
2
Cervical Osteochondroma Causing Myelopathy in Adults: Management Considerations and Literature Review. (27777159)
2017
3
Pediatric Trigger Finger due to Osteochondroma: A Report of Two Cases. (28082852)
2017
4
Identification of a new mutation in an Iranian family with hereditary multiple osteochondromas. (28053536)
2017
5
Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle. (26865041)
2016
6
Coracoid-like osteochondroma and painful giant thoracic bursitis. (26677990)
2016
7
NFAT restricts osteochondroma formation from entheseal progenitors. (27158674)
2016
8
Subungual osteochondroma: Nail sparing excision. (28018078)
2016
9
Response to the comment to: "Kulkarni U and Kulkarni A: Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg. 2015 Sep;21(3):e51-4a8^. (27810031)
2016
10
Compressive Myelopathy due to Osteochondroma of the Atlas and Review of the Literature. (26734949)
2016
11
Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas. (26961984)
2016
12
Diode laser ablation of a tracheal osteochondroma in a dog. (27112714)
2016
13
Trauma-Induced Resolution of Solitary Osteochondroma of the Distal Femur. (27337667)
2016
14
Osteochondroma Complicated by a Popliteal Vein Aneurysm- A Rare Case Report. (27790548)
2016
15
Osteochondroma of Bilateral Mandibular Condyle with Review of Literature. (27656529)
2016
16
Novel mutation of EXT2 identified in a large family with multiple osteochondromas. (27748933)
2016
17
Osteochondroma of the condyle: case report with 15 years of follow-up. (27156430)
2016
18
Giant osteochondroma of the C5 lamina in a young male. (26795102)
2016
19
Osteochondroma of maxillofacial region: Tumor arising from two different developmental bones. (27601834)
2016
20
Guideline for the Treatment of Condylar Osteochondroma Combined With Secondary Dentofacial Deformities. (27258707)
2016
21
Osteochondroma Arising from Anterior Inferior Iliac Spine as a Cause of Snapping Hip. (26929811)
2016
22
Osteochondroma of the lumbar spine. (27318638)
2016
23
What Lies Beneath: Acropachy Hiding Subungual Osteochondroma. (27658687)
2016
24
Identification of a novel frameshift mutation of the EXT2 gene in a family with multiple osteochondroma. (26870176)
2016
25
Severe chronic compression of the spinal cord by a C2 laminar osteochondroma in a 71-year-old woman: A case report. (27751750)
2016
26
Spinous Process Osteochondroma as a Rare Cause of Lumbar Pain. (27579204)
2016
27
Solitary osteochondroma arising in lumbar spinous process: CaseA report. (27887879)
2016
28
Comment to: Kulkarni U. Posterior talus osteochondroma a rare location, treated by posterior ankle arthroscopy. Foot Ankle Surg 2015;21(Sep (3)):e51-4. (27810030)
2016
29
Endoscopically Assisted Resection of a Rare Mass: Intra-Articular Osteochondroma of Shoulder Originated from Scapula. (26925280)
2016
30
Large solitary osteochondroma of the thoracic spine: Case report and review of the literature. (27274405)
2016
31
Unilateral mandibular condylar osteochondroma treated with ipsilateral condylectomy and contralateral ramus osteotomy. (27131256)
2016
32
Temporomandibular Joint Condylar Osteochondroma: Complete Condylectomy and Joint Replacement Versus Low Condylectomy and Joint Preservation. (26721449)
2016
33
Osteochondroma. (27712895)
2016
34
Repeated otalgia at mealtimes: osteochondroma of the mandibular condyle. (27903414)
2016
35
Osteochondroma of the Radial Tuberosity in Child. (27454513)
2016
36
Preoperative and postoperative examination ofA occlusal and maxillofacial changes after osteochondroma extirpation. (26827983)
2016
37
Surgical Treatment of Osteochondroma. (27315315)
2016
38
Osteochondroma Presenting as a Calcified Mass in the Sellar Region and Review of the Literature. (27903019)
2016
39
Letter to the Editor: Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. (27574283)
2016
40
Retrocalcaneal Bursitis due to Rare Calcaneal Osteochondroma in Adult Male : Excision and Outcome. (27703931)
2016
41
Paraarticular osteochondroma of a lumbar facet joint presenting with radiculopathy. (27503186)
2016
42
Talar Osteochondroma Fracture Presenting as Posterior Ankle Impingement. (27269978)
2016
43
Extensive Osteochondroma of Talus Presenting as Tarsal Tunnel Syndrome: Report of a case and Literature Review. (27517075)
2016
44
Cervical myelopathy due to a solitary osteochondroma: a case report. (27186499)
2016
45
Osteochondromatosis and osteochondroma involving bilateral patella and patellar tendon: a case report. (27122528)
2016
46
A giant multi-lobed osteochondroma of the phalanx in an adult: A case report. (28076750)
2016
47
Bilateral Scapulothoracic Osteochondromas in a Patient With Hereditary Multiple Exostosis: A Case Report and Review of the Literature. (27761218)
2016
48
SOLITARY OSTEOCHONDROMA OF THE DISTAL THIRD METACARPAL BONE IN A TWO-YEAR-OLD WHITE RHINOCEROS (CERATOTHERIUM SIMUM). (28080922)
2016
49
Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat? (26239617)
2015
50
Endoscopic Excision of Osteochondroma of the Mandibular Angle. (26430650)
2015

Variations for Osteochondroma

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Expression for genes affiliated with Osteochondroma

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Search GEO for disease gene expression data for Osteochondroma.

Pathways for genes affiliated with Osteochondroma

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Pathways related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathwaysScoreTop Affiliating Genes
19.7FGF2, FGFR1, FGFR3
2
Show member pathways
9.6FGF2, FGF9, FGFR3
3
Show member pathways
9.6FGF2, FGF9, FGFR1
4
Show member pathways
9.5EXT1, EXT2, FGFR1, PTHLH
59.4FGF2, FGFR1, TGFB2
69.3BMPR1B, FGF2, FGFR1, FGFR3
7
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
8
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
9
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
10
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
11
Show member pathways
9.3FGF2, FGF9, FGFR1, FGFR3
12
Show member pathways
9.2CDKN1A, E2F1, FGFR3
13
Show member pathways
9.2BCL2, BMPR1B, FGFR1, FGFR3
14
Show member pathways
9.2FGF2, FGFR1, FGFR3, TGFB2
159.1BCL2, CDKN1A, FGF2, VIM
169.0CDKN1A, FGF2, FGFR1, TGFB2
179.0BCL2, CDKN1A, E2F1
18
Show member pathways
8.9CDKN1A, E2F1, FGFR1, FGFR3
198.9FGF2, FGFR1, FGFR3, PTHLH, TGFB2
20
Show member pathways
8.9CDKN1A, FGF2, FGF9, FGFR1, FGFR3
218.8BMP2, FGF2, TGFB2
22
Show member pathways
8.8FGF2, FGF9, FGFR1, FGFR3, TGFB2
23
Show member pathways
8.8BMP2, BMPR1B, TGFB2
248.5BCL2, CDKN1A, FGF2, FGF9, FGFR1, FGFR3
25
Show member pathways
8.4BMP2, FGF2, FGFR1, FGFR3, TGFB2
268.4BMP2, FGF2, FGFR1, FGFR3, TGFB2
27
Show member pathways
8.2BCL2, CDKN1A, FGF2, FGF9, FGFR1, FGFR3
288.2BCL2, BMP2, CDKN1A, E2F1
298.0BMP2, FGF2, FGFR1, FGFR3, NES, S100B
308.0BCL2, CDKN1A, E2F1, FGFR3, TGFB2, VIM
31
Show member pathways
7.9BMP2, BMPR1B, E2F1, FGF2, TGFB2
32
Show member pathways
7.8BCL2, CDKN1A, E2F1, FGF2, FGF9, FGFR1
337.6BCL2, BMP2, CDKN1A, E2F1, TGFB2
34
Show member pathways
7.5BCL2, BMP2, BMPR1B, FGF2, FGFR1, FGFR3
35
Show member pathways
7.1BCL2, BMP2, BMPR1B, CDKN1A, FGF2, FGFR1
36
Show member pathways
7.1BCL2, BMP2, CDKN1A, FGF2, FGF9, FGFR1
376.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
38
Show member pathways
6.5BCL2, BMP2, CDKN1A, E2F1, FGF2, FGF9
39
Show member pathways
6.3BCL2, BMP2, BMPR1B, CDKN1A, E2F1, FGF2

GO Terms for genes affiliated with Osteochondroma

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Biological processes related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1cellular polysaccharide biosynthetic processGO:003369210.8EXT1, EXT2
2heparan sulfate proteoglycan biosynthetic processGO:001501210.8EXT1, EXT2
3heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processGO:001501410.8EXT1, EXT2
4positive regulation of phospholipase activityGO:001051810.7FGFR1, FGFR3
5positive regulation of endothelial cell chemotaxis to fibroblast growth factorGO:200054610.6FGF2, FGFR1
6positive regulation of phospholipase C activityGO:001086310.6FGF2, FGFR1
7lung-associated mesenchyme developmentGO:006048410.6FGF9, FGFR1
8generation of neuronsGO:004869910.5FGFR1, TGFB2
9embryonic digestive tract developmentGO:004856610.4FGF9, TGFB2
10positive regulation of cardiac muscle cell proliferationGO:006004510.3FGF2, FGF9, FGFR1
11salivary gland morphogenesisGO:000743510.3FGFR1, TGFB2
12mesenchymal cell differentiationGO:004876210.2BMP2, FGFR1
13fibroblast growth factor receptor signaling pathwayGO:000854310.1FGF2, FGF9, FGFR1, FGFR3
14embryonic limb morphogenesisGO:003032610.1FGF9, FGFR1, TGFB2
15MAPK cascadeGO:000016510.1FGF2, FGF9, FGFR1, FGFR3
16peptidyl-tyrosine phosphorylationGO:001810810.1FGF2, FGF9, FGFR1, FGFR3
17phosphatidylinositol phosphorylationGO:004685410.1FGF2, FGF9, FGFR1, FGFR3
18phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.1FGF2, FGF9, FGFR1, FGFR3
19phosphatidylinositol-mediated signalingGO:004801510.1FGF2, FGF9, FGFR1, FGFR3
20positive regulation of cartilage developmentGO:006103610.1BMP2, BMPR1B
21positive regulation of cell divisionGO:005178110.0FGF2, FGF9, TGFB2
22eye developmentGO:000165410.0BMPR1B, FGF9, TGFB2
23regulation of phosphatidylinositol 3-kinase signalingGO:00140669.9FGF2, FGF9, FGFR1, FGFR3
24atrioventricular valve morphogenesisGO:00031819.9BMP2, TGFB2
25cardiac epithelial to mesenchymal transitionGO:00603179.9BMP2, TGFB2
26endocardial cushion morphogenesisGO:00032039.9BMP2, TGFB2
27male gonad developmentGO:00085849.9BCL2, FGF9, TGFB2
28stem cell proliferationGO:00720899.9FGF2, NES
29pathway-restricted SMAD protein phosphorylationGO:00603899.9BMP2, TGFB2
30response to glucocorticoidGO:00513849.9BCL2, CDKN1A, S100B
31cellular response to hypoxiaGO:00714569.9BCL2, E2F1, S100B
32positive regulation of ossificationGO:00457789.8BMP2, TGFB2
33angiogenesisGO:00015259.8FGF2, FGF9, FGFR1, TGFB2
34branching involved in ureteric bud morphogenesisGO:00016589.7BCL2, BMP2, FGF2
35BMP signaling pathwayGO:00305099.6BMP2, BMPR1B, TGFB2
36ossificationGO:00015039.5BCL2, BMP2, EXT1, EXT2
37chondrocyte differentiationGO:00020629.2BMP2, BMPR1B, FGF9, FGFR1, FGFR3
38negative regulation of gene expressionGO:00106299.2BMP2, CDKN1A, FGFR1, TGFB2
39SMAD protein signal transductionGO:00603959.1BMP2, TGFB2, VIM
40cell-cell signalingGO:00072679.1BMP2, FGF9, FGFR3, PTHLH, TGFB2
41positive regulation of MAPK cascadeGO:00434109.0BMP2, DUSP19, FGF9, FGFR1, FGFR3
42protein phosphorylationGO:00064688.9BMP2, BMPR1B, FGFR1, FGFR3, TGFB2
43negative regulation of cell proliferationGO:00082858.8BCL2, BMP2, CDKN1A, PTHLH, TGFB2
44positive regulation of gene expressionGO:00106288.6BMP2, E2F1, FGF9, TGFB2, VIM
45positive regulation of cell proliferationGO:00082848.5BCL2, FGF2, FGF9, FGFR1, FGFR3, PTHLH
46skeletal system developmentGO:00015018.3BMP2, BMPR1B, EXT1, FGFR1, FGFR3, PTHLH

Molecular functions related to Osteochondroma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activityGO:005050810.8EXT1, EXT2
2heparan sulfate N-acetylglucosaminyltransferase activityGO:004232810.8EXT1, EXT2
3N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGO:005050910.8EXT1, EXT2
4fibroblast growth factor-activated receptor activityGO:000500710.7FGFR1, FGFR3
51-phosphatidylinositol-3-kinase activityGO:001630310.1FGF2, FGF9, FGFR1, FGFR3
6phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.0FGF2, FGF9, FGFR1, FGFR3
7receptor-receptor interactionGO:00907229.9FGF2, FGFR1
8protein tyrosine kinase activityGO:00047139.9FGF2, FGF9, FGFR1, FGFR3
9Ras guanyl-nucleotide exchange factor activityGO:00050889.4FGF2, FGF9, FGFR1, FGFR3
10growth factor activityGO:00080839.2BMP2, FGF2, FGF9, TGFB2
11protein homodimerization activityGO:00428039.1BCL2, EXT1, EXT2, FGFR1, S100B, TGFB2
12protein heterodimerization activityGO:00469828.9BCL2, BMP2, EXT1, EXT2, TGFB2

Sources for Osteochondroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
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33IUPHAR
34KEGG
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41MGI
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67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet