MCID: OST016
MIFTS: 58

Osteochondrosis malady

Bone diseases category
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Summaries for Osteochondrosis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards: Osteochondrosis, also known as osteochondritis juvenilis, is related to osteoarthritis and legg-calve-perthes disease. An important gene associated with Osteochondrosis is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Cardiac Progenitor Differentiation and Endochondral Ossification. The compounds proliferin and aminoglutethimide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Wikipedia:65 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Aliases & Classifications for Osteochondrosis

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Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondrosis 8 10 31
osteochondritis juvenilis 8 62
juvenile osteochondrosis of tibial tubercle 62
osteochondrosis not specified as adult 8
juvenile, of unspecified site 8
epiphyseal necrosis, nos 8
osteochondrosis nos 8
osteochondritis nos 8
epiphysitis nos 8
apophysitis nos 8


External Ids:

Disease Ontology8 DOID:8125
MeSH35 D055034
NCIt40 C34879

Related Diseases for Osteochondrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1osteoarthritis30.2NR3C1, OSM, IGF1
2legg-calve-perthes disease10.4
3blount's disease10.4
4osteochondritis dissecans10.3
5osgood-schlatter's disease10.3
6scheuermann's disease10.3
7cervicitis10.3
8kohler's disease10.2
9sinding-larsen-johansson disease10.2
10panner disease10.2
11freiberg's disease10.1
12familial scheuermann disease10.1
13fetal macrosomia10.1IGF2
14insulin-like growth factor 1 resistance to10.0IGF2, IGF1
15laron syndrome10.0IGF2, IGF1
16kaposi's sarcoma10.0OSM, NR3C1
17growth retardation-mild developmental delay-chronic hepatitis syndrome10.0IGF2, IGF1
18growth hormone deficiency10.0IGF2, IGF1
19spondylosis10.0
20osteopoikilosis10.0
21achondrogenesis type ib10.0
22metaphyseal dysplasia10.0
23kienbock's disease10.0
24sialidosis type i10.0
25stickler syndrome type 110.0
26thanatophoric dysplasia type 110.0
27upington disease10.0
28mucopolysaccharidosis ih10.0
29osteochondritis of tarsal/metatarsal bone10.0
30thiemann disease, familial form10.0
31hyperinsulinism10.0IGF2, IGF1
32seminoma10.0IGF2, MMP16
33uterine fibroid10.0IGF1, IGF2
34acromegaly10.0IGF2, IGF1
35glucose intolerance10.0NR3C1, IGF1
36cushing's syndrome10.0IGF1, NR3C1
37short stature10.0IGF2, IGF1
38hypertrophy of breast10.0IGF1, IGF2, OSM
39polycystic ovary syndrome10.0IGF2, IGF1
40myeloma10.0IGF1, OSM, NR3C1
41hyperandrogenism10.0NR3C1, IGF2, IGF1
42insulin resistance10.0IGF1, IGF2, NR3C1
43osteosarcoma9.9IGF1, IGF2, OSM, NR3C1
44adenoma9.9OSM, IGF2, IGF1
45prostate cancer9.9NR3C1, OSM, IGF2, IGF1
46neurofibromatosis9.9
47mccune albright syndrome9.9
48nail-patella syndrome9.9
49marshall-smith syndrome9.9
50spinal stenosis9.9

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms for Osteochondrosis

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Drugs & Therapeutics for Osteochondrosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

Search ClinicalTrials for Osteochondrosis

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Osteochondrosis:

33
Bone, Testes

FMA organs/tissues related to Osteochondrosis:

14
Bone

Animal Models for Osteochondrosis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Osteochondrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.0NCDN, NR3C1, IGF2, IGF1
2MP:00053698.8IGF1, IGF2, NR3C1, XIRP2
3MP:00107718.6IGF1, IGF2, OSM, NR3C1, XIRP2
4MP:00053908.6NCDN, NR3C1, MMP16, IGF2, IGF1
5MP:00053868.4IGF2, OSM, NR3C1, NCDN, XIRP2
6MP:00036318.3IGF1, IGF2, OSM, NR3C1, NCDN
7MP:00107687.9IGF1, IGF2, MMP16, NR3C1, NCDN, XIRP2
8MP:00028737.9IGF1, MMP16, NR3C1, GALNT13, XIRP2

Publications for Osteochondrosis

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Sources:
52PubMed
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Articles related to Osteochondrosis:

(show top 50)    (show all 366)
idTitleAuthorsYear
1
Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs. (23922127)
2013
2
Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis. (23939946)
2013
3
Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine. (23590509)
2013
4
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
5
Further evidence for better prevention of equine osteochondrosis. (23335686)
2013
6
Associations between osteochondrosis and conformation and locomotive characteristics in pigs. (22871924)
2012
7
Van neck disease: osteochondrosis of the ischiopubic synchondrosis. (21654459)
2011
8
Gene expression profiling from leukocytes of horses affected by osteochondrosis. (20108324)
2010
9
Genome-wide association analysis of osteochondrosis of the tibiotarsal joint in Norwegian Standardbred trotters. (21070284)
2010
10
Sacral osteochondrosis in two German Shepherd Dogs. (19489784)
2009
11
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
12
Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs. (18564254)
2008
13
The use of fresh allografts in osteochondrosis dissecans of the lateral femoral condyle. (16953349)
2006
14
Osteochondrosis associated with copper deficiency in a red deer herd in Norway. (15581144)
2004
15
Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosis. (14719712)
2004
16
Osteochondrosis of the occipital condyles and atlanto-occipital dysplasia in a Belgian horse. (14703085)
2003
17
Nutrition and osteochondrosis. (9463862)
1998
18
Osteochondrosis of the femur. (9463860)
1998
19
Radiologic case study. Tibia vara (osteochondrosis deformans tibiae). (8936537)
1996
20
Osteochondrosis in a pedigree Suffolk ram. (8650917)
1996
21
Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis. (8175922)
1994
22
Comparison of the diagnostic accuracy of positive-contrast arthrography and arthrotomy in evaluation of osteochondrosis lesions in the scapulohumeral joint in dogs. (8407466)
1993
23
Economic relevance, diagnosis, and countermeasures for degenerative joint disease (osteoarthrosis) and dyschondroplasia (osteochondrosis) in pigs. (2200764)
1990
24
Atypical osteochondrosis in a four-month-old foal. (3366111)
1988
25
Osteochondrosis of the temporomandibular joint presenting as an apparent parotid mass. (3605957)
1987
26
General and local [corrected] aetiologic factors in canine osteochondrosis. (3672862)
1987
27
Observation on the development of osteochondrosis in young rats. (3795864)
1986
28
Osteochondrosis of the tarsal cuneiforms. (3995827)
1985
29
Cervical osteochondrosis and disc herniation. Eighteen years' use of interbody fusion by Cloward's technique in 755 cases. (6711365)
1984
30
Osteochondrosis dissecans of the knee. Results of operative treatment in juveniles. (6712421)
1984
31
Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses. (7056680)
1982
32
Fusarium-induced osteochondrosis (tibial dyschondroplasia) in chickens. (7147613)
1982
33
Osteochondrosis in feedlot cattle. (7257092)
1981
34
Age related changes and osteochondrosis in swine articular and epiphyseal cartilage: light ane electron microscopy. (7260732)
1981
35
Osteochondrosis of the shoulder joint of the horse. (7214917)
1981
36
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
37
Osteochondrosis in the horse. II. Pathology. (233595)
1978
38
Osteochondrosis in domestic animals. Introduction. (233603)
1978
39
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
40
Juvenile osteochondrosis. (271835)
1977
41
Osteochondrosis in the horse. (1110665)
1975
42
Osteochondrosis of the vertebrae in a dog. (5462583)
1970
43
TIBIA VARA (OSTEOCHONDROSIS DEFORMANS TIBIAE): A SURVEY OF SEVENTY-ONE CASES. (14213402)
1964
44
TIBIA VARA (OSTEOCHONDROSIS DEFORMANS TIBIAE OR BLOUNT'S DISEASE). TREATMENT AND FOLLOW-UP EXAMINATION. (14209243)
1964
45
Osteochondrosis of the capitellum (Panner's disease). Report of a case. (14456742)
1962
46
Osteochondrosis deformans juvenilis dorsi. (13770264)
1961
47
Osteochondrosis of the capitulum humeri (Panners' disease); report of a case. (13606439)
1958
48
Observations on the differential diagnosis and sequelae of juvenile vertebral osteochondrosis. (13228191)
1954
49
Tibia vara; (osteochondrosis deformans tibiae); a survey of 23 cases. (14923172)
1952
50
Preventive and conservative treatment of osteochondrosis dissecans. (14894212)
1951

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Osteochondrosis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB, 51PharmGKB
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Compounds related to Osteochondrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1proliferin4510.2NR3C1, IGF2
2aminoglutethimide45 1111.2NR3C1, IGF2
3ag 10244510.2IGF2, IGF1
4cetrorelix45 29 1112.2IGF1, IGF2
52,4-dinitrophenol4510.2IGF1, IGF2
6nandrolone45 2411.2NR3C1, IGF1
7pegvisomant45 1111.2IGF2, IGF1
8eb 108945 6111.1IGF1, IGF2
9cortisone45 2411.1NR3C1, IGF1
10estrone sulfate45 2411.1IGF2, IGF1
11bromocriptine45 29 1112.1IGF2, IGF1
12dehydroepiandrosterone sulfate4510.1IGF2, IGF1
13progestins4510.0IGF2, NR3C1
14n-(4-hydroxyphenyl)retinamide4510.0IGF2, IGF1
152-deoxyglucose45 1111.0IGF2, IGF1
16octreotide45 61 29 1113.0IGF1, IGF2
17alginate4510.0OSM, IGF1
18c-peptide459.9IGF2, IGF1
19megestrol acetate459.9NR3C1, IGF2, IGF1
20dhea459.9NR3C1, IGF2, IGF1
214-hydroxytamoxifen459.9IGF1, IGF2, NR3C1
22progestin459.9IGF1, IGF2, NR3C1
23hydrocortisone45 3 61 1112.9IGF1, IGF2, NR3C1
24triiodothyronine459.8IGF2, IGF1
25dihydrotestosterone45 29 24 1112.8NR3C1, IGF2, IGF1
26phenobarbital45 29 51 1112.8NR3C1, IGF2
27etoposide45 51 61 1112.8NR3C1, IGF2, IGF1
28vitamin d459.8NR3C1, IGF2, IGF1
29rapamycin459.8IGF1, IGF2, NR3C1
30ly294002459.7NR3C1, IGF2, IGF1
31actinomycin d459.7IGF1, IGF2, NR3C1
32agar459.7IGF2, OSM, NR3C1
33androstenedione45 2410.7IGF2, IGF1
34glutamine459.7NR3C1, IGF2, IGF1
35glycosaminoglycan459.5MMP16, OSM, IGF2
36losartan45 51 29 1112.5IGF1, MMP16
37aprotinin45 1110.5IGF2, IGF1
38thymidine45 2410.4OSM, IGF2, IGF1
39acth459.4NR3C1, OSM, IGF2, IGF1
40estradiol45 24 1111.4NR3C1, OSM, IGF2, IGF1
41cycloheximide459.4IGF1, IGF2, OSM, NR3C1
42steroid459.4IGF1, IGF2, OSM, NR3C1
43dexamethasone45 51 29 1112.4NR3C1, OSM, IGF2, IGF1
44estrogen459.3IGF1, IGF2, OSM, NR3C1
45retinoic acid45 2410.3NR3C1, OSM, IGF2, IGF1
46vegf458.8IGF1, IGF2, OSM, MMP16, NR3C1

GO Terms for genes affiliated with Osteochondrosis

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16Gene Ontology
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Cellular components related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.8IGF2, IGF1

Biological processes related to Osteochondrosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1exocrine pancreas developmentGO:03101710.0IGF1, IGF2
2positive regulation of glycogen biosynthetic processGO:04572510.0IGF2, IGF1
3positive regulation of activated T cell proliferationGO:04210410.0IGF2, IGF1
4positive regulation of mitosisGO:0458409.9IGF2, IGF1
5positive regulation of cell divisionGO:0517819.8IGF2, OSM
6positive regulation of protein kinase B signalingGO:0518979.7IGF1, IGF2
7positive regulation of catalytic activityGO:0430859.6MMP16, IGF2
8positive regulation of MAPK cascadeGO:0434109.6OSM, IGF2, IGF1
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6OSM, IGF2, IGF1
10platelet degranulationGO:0025769.5IGF2, IGF1
11positive regulation of cell proliferationGO:0082849.3OSM, IGF2, IGF1
12cellular protein metabolic processGO:0442679.0GALNT13, IGF2, IGF1

Molecular functions related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.8IGF2, IGF1
2hormone activityGO:0051799.8IGF2, IGF1
3insulin receptor bindingGO:0051589.5IGF2, IGF1
4growth factor activityGO:0080839.2OSM, IGF2, IGF1

Products for genes affiliated with Osteochondrosis

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Sources for Osteochondrosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet