MCID: OST016
MIFTS: 51

Osteochondrosis malady

Bone diseases category

Summaries for Osteochondrosis

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards: Osteochondrosis, also known as osteochondritis juvenilis, is related to osteoarthritis and legg-calve-perthes disease. An important gene associated with Osteochondrosis is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Endochondral Ossification. The compounds proliferin and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotype skeleton.

Wikipedia:63 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Aliases & Classifications for Osteochondrosis

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Sources:
8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondrosis 8 10 30
osteochondritis juvenilis 8 60
juvenile osteochondrosis of tibial tubercle 60
osteochondrosis not specified as adult 8
juvenile, of unspecified site 8
epiphyseal necrosis, nos 8
osteochondritis nos 8
osteochondrosis nos 8
apophysitis nos 8
epiphysitis nos 8


External Ids:

Disease Ontology8 DOID:8125
MeSH34 D055034
NCIt39 C34879

Related Diseases for Osteochondrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1osteoarthritis30.1OSM, NR3C1, IGF1, ACAN
2legg-calve-perthes disease10.4
3osteochondritis dissecans10.3
4blount's disease10.3
5osgood-schlatter's disease10.2
6scheuermann's disease10.2
7cervicitis10.2
8kohler's disease10.2
9sinding-larsen-johansson disease10.2
10freiberg's disease10.1
11familial scheuermann disease10.1
12panner disease10.1
13fibrosarcoma10.0OSM
14retinoblastoma10.0OSM
15pulmonary fibrosis10.0OSM
16spondylosis10.0
17osteopoikilosis10.0
18achondrogenesis type ib10.0
19metaphyseal dysplasia10.0
20stickler syndrome type 110.0
21kienbock's disease10.0
22sialidosis type i10.0
23upington disease10.0
24thanatophoric dysplasia type 110.0
25mucopolysaccharidosis ih10.0
26osteochondritis of tarsal/metatarsal bone10.0
27thiemann disease, familial form10.0
28fetal macrosomia10.0IGF2
29arthropathy10.0OSM, ACAN
30chronic fatigue syndrome10.0NR3C1
31cushing's syndrome10.0NR3C1
32arthritis10.0ACAN, OSM
33insulin-like growth factor 1 resistance to10.0IGF2, IGF1
34laron syndrome10.0IGF2, IGF1
35panhypopituitarism10.0IGF1
36pituitary adenoma10.0NR3C1, IGF1
37rheumatoid arthritis10.0OSM, NR3C1, ACAN
38growth retardation-mild developmental delay-chronic hepatitis syndrome10.0IGF1, IGF2
39hypertrophy of breast10.0OSM, IGF2, IGF1, ACAN
40hyperandrogenism10.0NR3C1, IGF2, IGF1
41bone fracture9.8
42neurofibromatosis9.8
43sjogren-larsson syndrome9.8
44fucosidosis9.8
45hajdu-cheney syndrome9.8
46mccune albright syndrome9.8
47spondyloepiphyseal dysplasia congenita9.8
48cartilage-hair hypoplasia9.8
49achondroplasia9.8
50camurati-engelmann disease9.8

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Clinical Features for Osteochondrosis

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Drugs & Therapeutics for Osteochondrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Osteochondrosis

Drug clinical trials:

Search ClinicalTrials for Osteochondrosis

Search NIH Clinical Center for Osteochondrosis

Search CenterWatch for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteochondrosis:

32
Bone, Testes

FMA organs/tissues related to Osteochondrosis:

14
Bone

Animal Models for Osteochondrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Osteochondrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.4ACAN, MMP16, IGF1, IGF2, NR3C1, NCDN

Publications for Osteochondrosis

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50PubMed
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Articles related to Osteochondrosis:

(show top 50)    (show all 369)
idTitleAuthorsYear
1
Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis. (23939946)
2013
2
Tissue mineral concentrations and osteochondrosis lesions in prolific sows across parities 0 through 7. (23296836)
2013
3
Lumbosacral osteochondrosis in cats. (23709091)
2013
4
Osteochondrosis dissecans of the tarsus in Labrador Retrievers: clinical signs, radiological data and force plate gait evaluation after surgical treatment. (22366924)
2012
5
Assessment of treatment of Osteochondrosis dissecans (OCD) of shoulder joint in dogs--the results of two years of experience. (22844706)
2012
6
Equine hospital data as a source for study of prevalence and heritability of osteochondrosis and palmar/plantar osseous fragments of Swedish Warmblood horses. (21615779)
2011
7
Cartilage thickness of the trochlea of the talus, with emphasis on sites predisposed to osteochondrosis dissecans, in clinically normal juvenile and adult dogs. (21962273)
2011
8
A case of bilateral patellar osteochondrosis and fracture in a cat. Clinical and histological findings. (20151080)
2010
9
Quantitative trait loci analysis of osteochondrosis traits in the elbow joint of pigs. (22443945)
2010
10
Sacral osteochondrosis in two German Shepherd Dogs. (19489784)
2009
11
Osteochondrosis juvenilis of the medial malleolar epiphysis. (18539678)
2008
12
Use of 3D geometry modeling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells. (17552888)
2007
13
The use of fresh allografts in osteochondrosis dissecans of the lateral femoral condyle. (16953349)
2006
14
Computer-assisted minimally invasive treatment of osteochondrosis dissecans of the talus. (17103129)
2006
15
Osteochondrosis dissecans of the shoulder glenoid fossa diagnosed in four throwing athletes. (16596108)
2006
16
Prevalence of osteochondrosis in the limb joints of South German Coldblood horses. (17105575)
2006
17
Pathogenetic basis for the use of GABA-ergic preparations in combination with atropine during chronic pain syndrome in patients with neurologic manifestations of lumbar osteochondrosis]. (10802884)
2000
18
Mapping quantitative trait loci for principal components of bone measurements and osteochondrosis scores in a wild boar x large white intercross. (10816979)
2000
19
Effect of age, exercise and growth rate on bone mineral density (BMD) in third carpal bone and distal radius of Dutch Warmblood foals with osteochondrosis. (10999664)
1999
20
Osteochondrosis and epiphyseal bone abnormalities associated with copper deficiency in bison calves. (10646064)
1999
21
Historical perspectives of osteochondrosis. (9463855)
1998
22
Osteochondrosis dissecans of the lateral femoral condyle before skeletal maturity. (9493994)
1997
23
Radiologic case study. Tibia vara (osteochondrosis deformans tibiae). (8936537)
1996
24
Osteochondrosis in a pedigree Suffolk ram. (8650917)
1996
25
Osteochondrosis dissecans of the talus. Comparison of results of surgical treatment in adolescents and adults. (1482614)
1992
26
Osteochondrosis and juvenile spavin in equids. (2053733)
1991
27
Spinal stenosis subsequent to juvenile lumbar osteochondrosis. (2333559)
1990
28
A radiographic survey of tibiotarsal osteochondrosis in a selected population of trotting horses in Denmark and its possible genetic significance. (2209527)
1990
29
Kohler's osteochondrosis of the tarsal navicular: case report with twenty-eight year follow up. (2799378)
1989
30
Plasma amino acids in dogs with osteochondrosis or hip dysplasia. (2782228)
1989
31
Osteochondrosis of the fourth metacarpal head after closed trauma. (3225419)
1988
32
Subchondral cystic lesions (osteochondrosis) of the femoral heads in a horse. (3356573)
1988
33
Observation on the development of osteochondrosis in young rats. (3795864)
1986
34
Osteochondrosis-like lesion of the anconeal process in two horses. (3771343)
1986
35
Dyschondroplasias, including osteochondrosis, in boars between 25 and 169 days of age: histologic changes. (6732023)
1984
36
A retrospective clinical study of osteochondrosis dissecans in 21 horses. (6651665)
1983
37
Tibia vara: osteochondrosis deformans tibiae. Blount's disease. (7273529)
1981
38
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
39
Osteochondrosis in six breeds of slaughter pigs. (22039856)
1980
40
Erosive intervertebral osteochondrosis in association with generalized osteoarthritis and chondroc alcinosis; anatomico-radiological study of a case. (532370)
1979
41
Osteochondrosis and arthrosis in pigs. II. Incidence in breeding animals. (4830069)
1974
42
Osteochondrosis of the vertebrae in a dog. (5462583)
1970
43
Osteochondrosis deformans tibiae. (4955399)
1965
44
Bilateral incurving of the terminal phalanges of the fifth fingers (osteochondrosis?). (13993534)
1963
45
Osteochondrosis of the capitellum (Panner's disease). Report of a case. (14456742)
1962
46
Early recognition of osteochondrosis of capital epiphysis of femur. (14406359)
1960
47
Late results in osteochondrosis of capital epiphysis of femur (Legg-CalvAc-Perthes disease). (13630770)
1959
48
On osteochondrosis deformas juvenilis capituli humeri including investigation of intra-osseous vasculature in distal humerus. (14399666)
1959
49
Osteochondrosis of an accessory ossification centre at the inferior pole of the patella. (Larsen-Johansson disease). (13108456)
1953
50
On treatment of osteochondrosis of the spine by spinal fusion. (18152750)
1949

Genetic Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Osteochondrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IGF1, IGF2
29.7IGF2, IGF1, ACAN
39.5IGF1, NR3C1, OSM
4
Cell adhesion ECM remodeling
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9.1ACAN, MMP16, IGF1, IGF2

Compounds for genes affiliated with Osteochondrosis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Osteochondrosis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1proliferin4410.2IGF2, NR3C1
2ag 10244410.2IGF1, IGF2
3nandrolone44 2411.2IGF1, NR3C1
4aminoglutethimide44 1111.1IGF2, NR3C1
52,4-dinitrophenol4410.1IGF1, IGF2
6cetrorelix44 28 1112.1IGF1, IGF2
7pegvisomant44 1111.1IGF2, IGF1
8megestrol acetate4410.0IGF1, IGF2, NR3C1
9dhea449.9NR3C1, IGF2, IGF1
104-hydroxytamoxifen449.9IGF1, IGF2, NR3C1
11alginate449.9OSM, IGF1, ACAN
12progestin449.9NR3C1, IGF2, IGF1
13cortisone44 2410.9IGF1, NR3C1
14hydrocortisone44 2 59 1112.7NR3C1, IGF2, IGF1
15vitamin d449.7ACAN, IGF1, IGF2, NR3C1
16acth449.6IGF1, IGF2, NR3C1, OSM
17dihydrotestosterone44 28 11 2412.5NR3C1, IGF2, IGF1
18glycosaminoglycan449.3ACAN, MMP16, IGF2, OSM
19tgf beta1449.3ACAN, IGF2, OSM
20dexamethasone44 49 28 1112.3OSM, NR3C1, IGF2, IGF1, ACAN
21estradiol44 11 2411.3IGF1, IGF2, NR3C1, OSM
22vegf448.7MMP16, IGF1, IGF2, NR3C1, OSM

GO Terms for genes affiliated with Osteochondrosis

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16Gene Ontology
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Biological processes related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.9IGF1, IGF2
2positive regulation of glycogen biosynthetic processGO:0457259.8IGF2, IGF1
3positive regulation of MAPK cascadeGO:0434109.6IGF1, IGF2, OSM
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IGF1, IGF2, OSM
5skeletal system developmentGO:0015019.4ACAN, IGF1, IGF2

Molecular functions related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.6IGF1, IGF2
2growth factor activityGO:0080839.5IGF1, IGF2, OSM

Products for genes affiliated with Osteochondrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet