MCID: OST016
MIFTS: 52

Osteochondrosis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteochondrosis

MalaCards integrated aliases for Osteochondrosis:

Name: Osteochondrosis 37 12 49 14 69
Osteochondritis Juvenilis 12 69
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 12
Juvenile Osteochondrosis of Tibial Tubercle 69
Epiphyseal Necrosis, Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8125
ICD10 32 M92 M93.9
ICD9CM 34 732.6
MeSH 41 D055034
NCIt 46 C34879

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis juvenilis, is related to osteoporosis and scheuermann disease. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Anesthetics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 osteoporosis 29.0 CD36 COL2A1 IGF1 NR3C1 TGFB1
2 scheuermann disease 12.0
3 legg-calve-perthes disease 12.0
4 kohler's disease 11.9
5 panner disease 11.8
6 blount's disease 11.7
7 osgood-schlatter's disease 11.5
8 kienbock's disease 11.2
9 sinding-larsen-johansson disease 11.2
10 thiemann disease 11.2
11 freiberg's disease 11.0
12 blount disease, infantile 10.8
13 blount disease, adolescent 10.8
14 pseudopapilledema 10.4 IGF1 IGF2
15 acid-labile subunit deficiency 10.4 IGF1 IGF2
16 fibromatosis, gingival, 1 10.4 CD36 TGFB1
17 fetal macrosomia 10.3 IGF1 IGF2
18 hypertrophic scars 10.3 CD36 TGFB1
19 aging 10.3
20 keloids 10.3 CD36 TGFB1
21 fasting hypoglycemia 10.3 CD36 IGF1 IGF2
22 rubeosis iridis 10.2 IGF1 IGF2
23 adult syndrome 10.2 IGF2 NR3C1
24 achondrogenesis, type ii 10.2 CD36 COL2A1
25 osteochondritis dissecans 10.2
26 hallermann-streiff syndrome 10.2 IGF1 IGF2
27 chronic fatigue syndrome 10.2 IGF1 NR3C1 TGFB1
28 small intestine leiomyosarcoma 10.2 IGF2 IHH
29 small intestinal sarcoma 10.2 IGF2 IHH
30 osteoarthritis 10.2
31 diastrophic dysplasia 10.1 COL2A1 TGFB1
32 laron syndrome 10.1 IGF1 IGF2
33 cervicitis 10.1
34 osteogenesis imperfecta, type v 10.1 CD36 IHH
35 episodic pain syndrome, familial, 1 10.1
36 peroneal nerve paralysis 10.0 COL2A1 TBXAS1
37 blood group, i system 10.0
38 osteoarthritis with mild chondrodysplasia 10.0
39 upington disease 10.0
40 sacral agenesis with vertebral anomalies 10.0
41 osteofibrous dysplasia 9.9 CD36 TGFB1
42 metaphyseal chondrodysplasia, jansen type 9.9 COL2A1 IHH
43 insulin-like growth factor i 9.9
44 spondylosis 9.9
45 ischemic bone disease 9.7 COL2A1 KLHDC2 TBXAS1
46 pyle disease 9.7
47 body mass index quantitative trait locus 11 9.7
48 paine syndrome 9.7
49 body mass index quantitative trait locus 9 9.7
50 body mass index quantitative trait locus 8 9.7

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

GenomeRNAi Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

25 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.58 SEMA3D
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.58 CD36
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 NR3C1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 CD36 NR3C1 SEMA3D
5 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 NR3C1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 CD36 NR3C1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 CD36
8 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.58 CD36
9 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.58 CD36
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 CD36
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 CD36
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 SEMA3D
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.58 SEMA3D
14 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.58 NR3C1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.58 SEMA3D
16 Decreased viability with paclitaxel GR00179-A-1 9.26 IGF1 TGFB1
17 Decreased viability with paclitaxel GR00179-A-2 9.26 IGF1
18 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Osteochondrosis:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 IHH IGF1 CD36 IGF2 COL2A1 SEMA3D
2 growth/size/body region MP:0005378 10.16 IHH IGF1 CD36 COL24A1 IGF2 COL2A1
3 behavior/neurological MP:0005386 10.14 COL2A1 CD36 COL24A1 IGF2 NR3C1 KLHDC2
4 immune system MP:0005387 10.06 IGF1 CD36 COL24A1 IGF2 COL2A1 NR3C1
5 digestive/alimentary MP:0005381 10.04 IHH CD36 IGF2 COL2A1 TGFB1 MMP16
6 hematopoietic system MP:0005397 10.03 IGF1 CD36 COL24A1 IGF2 NR3C1 TBXAS1
7 endocrine/exocrine gland MP:0005379 10.02 IGF1 CD36 IGF2 NR3C1 IHH KLHDC2
8 craniofacial MP:0005382 9.99 IGF2 COL2A1 IHH KLHDC2 TGFB1 MMP16
9 adipose tissue MP:0005375 9.95 COL2A1 IGF1 CD36 NR3C1 TGFB1
10 muscle MP:0005369 9.8 IGF1 CD36 IGF2 NR3C1 IHH TGFB1
11 limbs/digits/tail MP:0005371 9.77 IGF2 COL2A1 IGF1 IHH MMP16
12 renal/urinary system MP:0005367 9.73 COL2A1 IGF1 CD36 IGF2 NR3C1 TGFB1
13 respiratory system MP:0005388 9.63 COL2A1 IGF1 IGF2 NR3C1 IHH TGFB1
14 skeleton MP:0005390 9.56 IGF1 CD36 IGF2 COL2A1 NR3C1 IHH
15 vision/eye MP:0005391 9.17 CD36 IGF2 COL2A1 IHH KLHDC2 TGFB1

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2, Phase 3,Phase 1
2 Fibrin Tissue Adhesive Phase 2, Phase 3
3
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
4 Anesthetics, Local Phase 1, Phase 2
5 Anti-Arrhythmia Agents Phase 1, Phase 2
6 Central Nervous System Depressants Phase 1, Phase 2
7 Diuretics, Potassium Sparing Phase 1, Phase 2
8 Peripheral Nervous System Agents Phase 1, Phase 2
9 Sodium Channel Blockers Phase 1, Phase 2
10 Calcium, Dietary
11 Astragalus Nutraceutical

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
2 Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial Completed NCT00560664 Phase 3
3 Treatment of the Osgood Schlatter Recruiting NCT02824172 Phase 3
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379
6 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
7 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976
8 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Completed NCT02799394
9 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
10 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298
11 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278 Platelet rich plasma (PRP)
12 Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee Recruiting NCT03385642
13 AS: Ankle Spacer for Talar Osteochondral Defects Recruiting NCT03303690
14 ReNu™ Marrow Stimulation Augmentation Recruiting NCT03036878
15 Cytokine Profiles in Spondylodiscitis Recruiting NCT02554227
16 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects Active, not recruiting NCT02423629
17 A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
18 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee Withdrawn NCT02308358
19 Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Withdrawn NCT01631409 Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;Aspirin, Isosorbide mononitrate, Atenolol, Enalapril

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

18
Bone

MalaCards organs/tissues related to Osteochondrosis:

38
Bone, Bone Marrow, Testes

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 420)
# Title Authors Year
1
Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. ( 29373573 )
2018
2
Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis. ( 28830435 )
2017
3
Response of cattle with clinical osteochondrosis to mineral supplementation. ( 28281772 )
2017
4
Ultrasonographic screening for subclinical osteochondrosis of the femoral trochlea in foals (28-166 days old): a prospective farm study. ( 29044618 )
2017
5
Osteochondrosis, Synovial Fossae, and Articular Indentations in the Talus and Distal Tibia of Growing Domestic Pigs and Wild Boars. ( 28129094 )
2017
6
High Levels of Circulating Type II Collagen Degradation Marker (CTx-II) Are Associated with Specific VDR Polymorphisms in Patients with Adult Vertebral Osteochondrosis. ( 28961166 )
2017
7
Validation of the ultrasonographic assessment of the femoral trochlea epiphyseal cartilage in foals at osteochondrosis predilected sites with magnetic resonance imaging and histology. ( 28470772 )
2017
8
Osteochondrosis of the medial malleolar epiphysis: A case report and review of the literature. ( 28846950 )
2017
9
Surgical Management of Osteochondrosis in Foals. ( 28687096 )
2017
10
Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over. ( 28398504 )
2017
11
Prevalence and severity of osteochondrosis of the free thoracic vertebra in three modern broiler strains and the Athens Canadian Random Bred control broiler. ( 28975826 )
2017
12
Quantitative and qualitative aspects of standing-up behavior and the prevalence of osteochondrosis in Warmblood foals on different farms: could there be a link? ( 29121926 )
2017
13
Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second-harmonic microscopy, and histological findings. ( 27734566 )
2016
14
Vitamin D Deficiency: The Missing Etiological Factor in the Development of Juvenile Osteochondrosis Dissecans? ( 28009798 )
2016
15
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. ( 27283998 )
2016
16
The development of locomotor kinetics in the foal and the effect of osteochondrosis. ( 27859501 )
2016
17
Direct comparison of different surgical approaches in a woman with bilateral osteochondrosis dissecans of her knees: a case report. ( 26786243 )
2016
18
Impact of feeding and housing on the development of osteochondrosis in foals-A longitudinal study. ( 27094134 )
2016
19
Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis-susceptible sites in foals revealed by SWI 3T MRI. ( 26740060 )
2016
20
Prevalence of humeral head osteochondrosis in the Greater Swiss Mountain dog and the Border Collie in Switzerland. ( 27821378 )
2016
21
Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses. ( 27448988 )
2016
22
Prevalence and characteristics of osteochondrosis in 309 Spanish Purebred horses. ( 26670332 )
2016
23
Candidate gene analysis of osteochondrosis in Spanish Purebred horses. ( 27422688 )
2016
24
Identification and validation of risk loci for osteochondrosis in standardbreds. ( 26753841 )
2016
25
Osteochondrosis dissecans of the temporomandibular joint: a case report and a review of literature. ( 27142101 )
2016
26
OSTEOCHONDROSIS IN THE DISTAL FEMURS OF AN ADULT RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS RETICULATA): MACROSCOPIC, RADIOLOGIC, AND HISTOLOGIC FINDINGS. ( 27010303 )
2016
27
Preliminary report on osteochondrosis in cattle in the north-western parts of South Africa. ( 27543146 )
2016
28
Osteochondrosis prevalence and severity at 12 and 24 weeks of age in commercial pigs with and without organic-complexed trace mineral supplementation. ( 27898885 )
2016
29
Dissolution of the capitellum after nondisplaced supracondylar fracture of the humerus in a child: a case report of transient osteochondrosis. ( 25647568 )
2015
30
Associations of conformation and locomotive characteristics in growing gilts with osteochondrosis at slaughter. ( 25568360 )
2015
31
Identification of novel osteochondrosis- associated genes. ( 26296056 )
2015
32
Osteochondrosis of the accessory ossification centre of the medial malleolus. ( 25438106 )
2015
33
Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis. ( 25463443 )
2015
34
Bilateral osteochondrosis of the distal tibial epiphysis: a case report. ( 25504104 )
2015
35
Wnt/ I^-catenin signaling of cartilage canal and osteochondral junction chondrocytes and full thickness cartilage in early equine osteochondrosis. ( 25676127 )
2015
36
Age-dependent expression of osteochondrosis-related genes in equine leukocytes. ( 26392886 )
2015
37
Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model. ( 26473611 )
2015
38
Osteochondrosis, but not lameness, is more frequent among free-range pigs than confined herd-mates. ( 26416598 )
2015
39
An Update on the Pathogenesis of Osteochondrosis. ( 26080832 )
2015
40
Ossification defects detected in CT scans represent early osteochondrosis in the distal femur of piglets. ( 24740876 )
2014
41
DIAGNOSTIC SENSITIVITY OF RADIOGRAPHY, ULTRASONOGRAPHY, AND MAGNETIC RESONANCE IMAGING FOR DETECTING SHOULDER OSTEOCHONDROSIS/OSTEOCHONDRITIS DISSECANS IN DOGS. ( 24844132 )
2014
42
Genetic trends of conformation traits and genetic correlations to osteochondrosis in boars. ( 24816139 )
2014
43
Consequences of the natural course of articular osteochondrosis in pigs for the suitability of computed tomography as a screening tool. ( 25199991 )
2014
44
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses. ( 25428408 )
2014
45
Treatment of Osteochondrosis Dissecans in the Stifle and Tarsus of Juvenile Thoroughbred Horses. ( 25243728 )
2014
46
Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. ( 25227120 )
2014
47
Bilateral osteochondrosis of the primary patellar ossification centers in a young athlete: a case report. ( 23797161 )
2014
48
The influence of floor type before and after 10 weeks of age on osteochondrosis in growing gilts. ( 24987085 )
2014
49
Short- and long-term racing performance of Standardbred pacers and trotters after early surgical intervention for tarsal osteochondrosis. ( 24819047 )
2014
50
Arthroscopic assessment of osteochondrosis of the medial humeral condyle treated with debridement and sliding humeral osteotomy. ( 25109907 )
2014

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.87 COL24A1 COL2A1 IGF1 IGF2 IHH MMP16
2 extracellular space GO:0005615 9.7 CD36 COL2A1 IGF1 IGF2 IHH SEMA3D
3 collagen trimer GO:0005581 9.43 CD36 COL24A1 COL2A1
4 platelet alpha granule lumen GO:0031093 9.13 IGF1 IGF2 TGFB1
5 proteinaceous extracellular matrix GO:0005578 9.02 COL24A1 COL2A1 IHH MMP16 TGFB1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 IGF1 IGF2 IHH TGFB1
2 regulation of gene expression GO:0010468 9.77 COL2A1 IGF1 TGFB1
3 positive regulation of MAPK cascade GO:0043410 9.63 CD36 IGF1 IGF2
4 liver regeneration GO:0097421 9.61 IHH TGFB1
5 cellular response to dexamethasone stimulus GO:0071549 9.58 NR3C1 TGFB1
6 cellular response to amyloid-beta GO:1904646 9.58 CD36 IGF1
7 ossification GO:0001503 9.58 COL2A1 IGF2 IHH
8 positive regulation of mitotic nuclear division GO:0045840 9.57 IGF1 IGF2
9 positive regulation of activated T cell proliferation GO:0042104 9.56 IGF1 IGF2
10 endochondral ossification GO:0001958 9.55 COL2A1 MMP16
11 positive regulation of collagen biosynthetic process GO:0032967 9.54 IHH TGFB1
12 response to fatty acid GO:0070542 9.52 CD36 TBXAS1
13 positive regulation of transcription regulatory region DNA binding GO:2000679 9.51 IGF1 TGFB1
14 cell activation GO:0001775 9.49 IGF1 TGFB1
15 positive regulation of glycogen biosynthetic process GO:0045725 9.48 IGF1 IGF2
16 skeletal system development GO:0001501 9.46 COL2A1 IGF1 IGF2 IHH
17 chondrocyte proliferation GO:0035988 9.43 IHH MMP16
18 positive regulation of epithelial cell proliferation GO:0050679 9.43 IGF1 IHH TGFB1
19 morphogenesis of a branching structure GO:0001763 9.37 IHH TGFB1
20 proteoglycan metabolic process GO:0006029 9.32 COL2A1 IHH
21 platelet degranulation GO:0002576 9.26 CD36 IGF1 IGF2 TGFB1
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 CD36 IGF1 IGF2 TGFB1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 IGF1 IGF2
2 protein serine/threonine kinase activator activity GO:0043539 9.16 IGF2 TGFB1
3 growth factor activity GO:0008083 9.13 IGF1 IGF2 TGFB1
4 insulin-like growth factor receptor binding GO:0005159 8.62 IGF1 IGF2

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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