Aliases & Classifications for Osteochondrosis

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Osteochondrosis, Aliases & Descriptions:

Name: Osteochondrosis 30 9 11 60
Osteochondritis Juvenilis 9 60
Juvenile Osteochondrosis of Tibial Tubercle 60
Osteochondrosis Not Specified As Adult 9
Juvenile, of Unspecified Site 9
 
Epiphyseal Necrosis, Nos 9
Osteochondritis Nos 9
Osteochondrosis Nos 9
Epiphysitis Nos 9
Apophysitis Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:8125
NCIt38 C34879
MeSH33 D055034

Summaries for Osteochondrosis

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Disease Ontology:9 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary: Osteochondrosis, also known as osteochondritis juvenilis, is related to osteoarthritis and legg-calve-perthes disease. An important gene associated with Osteochondrosis is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Endochondral Ossification and Response to elevated platelet cytosolic Ca2+. The compounds proliferin and aminoglutethimide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Wikipedia:63 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1osteoarthritis30.2NR3C1, OSM, IGF1
2legg-calve-perthes disease10.4
3fetal macrosomia10.4IGF2
4blount's disease10.4
5osteochondritis dissecans10.4
6kohler's disease10.3
7osgood-schlatter's disease10.3
8scheuermann's disease10.3
9cervicitis10.3
10insulin-like growth factor 1 resistance to10.1IGF2, IGF1
11kaposi sarcoma10.1OSM, NR3C1
12freiberg's disease10.1
13familial scheuermann disease10.1
14panner disease10.1
15sinding-larsen-johansson disease10.1
16laron dwarfism10.1IGF2, IGF1
17growth hormone deficiency10.1IGF2, IGF1
18hyperinsulinism10.1IGF2, IGF1
19uterine fibroid10.1IGF1, IGF2
20acromegaly10.1IGF2, IGF1
21seminoma10.0IGF2, MMP16
22glucose intolerance10.0NR3C1, IGF1
23thanatophoric dysplasia, type i10.0
24insulin-like growth factor i10.0
25sialidosis, type i10.0
26spondylosis10.0
27metaphyseal dysplasia10.0
28kienbock's disease10.0
29osteoarthropathy of fingers familial10.0
30upington disease10.0
31nutritional deficiency disease10.0IGF1, NR3C1
32cushing's syndrome10.0IGF1, NR3C1
33myeloma9.9IGF1, OSM, NR3C1
34hyperandrogenism9.9NR3C1, IGF2, IGF1
35schwartz-jampel syndrome, type 19.9
36fucosidosis9.9
37pycnodysostosis9.9
38acrofacial dysostosis 1, nager type9.9
39cinca syndrome9.9
40achondroplasia9.9
41hypochondroplasia9.9
42thanatophoric dysplasia, type ii9.9
43osteoporosis9.9
44treacher collins syndrome 19.9
45cleidocranial dysplasia9.9
46yunis-varon syndrome9.9
47mesomelia-synostoses syndrome9.9
48nail-patella syndrome9.9
49bannayan-riley-ruvalcaba syndrome9.9
50gracile bone dysplasia9.9

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms for Osteochondrosis

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Drugs & Therapeutics for Osteochondrosis

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Drug clinical trials:

Search ClinicalTrials for Osteochondrosis

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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MalaCards organs/tissues related to Osteochondrosis:

31
Bone, Testes

FMA organs/tissues related to Osteochondrosis:

14
Bone

Animal Models for Osteochondrosis or affiliated genes

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MGI Mouse Phenotypes related to Osteochondrosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.0NCDN, NR3C1, IGF2, IGF1
2MP:00053698.8IGF1, IGF2, NR3C1, XIRP2
3MP:00107718.6IGF1, IGF2, OSM, NR3C1, XIRP2
4MP:00053908.6NCDN, NR3C1, MMP16, IGF2, IGF1
5MP:00053868.4IGF2, OSM, NR3C1, NCDN, XIRP2
6MP:00036318.3IGF1, IGF2, OSM, NR3C1, NCDN
7MP:00107687.9IGF1, IGF2, MMP16, NR3C1, NCDN, XIRP2
8MP:00028737.9IGF1, MMP16, NR3C1, GALNT13, XIRP2

Publications for Osteochondrosis

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Articles related to Osteochondrosis:

(show top 50)    (show all 381)
idTitleAuthorsYear
1
Omics technologies provide new insights into the molecular physiopathology of equine osteochondrosis. (25359417)
2014
2
Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs. (23922127)
2013
3
Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis. (23939946)
2013
4
Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine. (23590509)
2013
5
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
6
Further evidence for better prevention of equine osteochondrosis. (23335686)
2013
7
Associations between osteochondrosis and conformation and locomotive characteristics in pigs. (22871924)
2012
8
Van neck disease: osteochondrosis of the ischiopubic synchondrosis. (21654459)
2011
9
Gene expression profiling from leukocytes of horses affected by osteochondrosis. (20108324)
2010
10
Genome-wide association analysis of osteochondrosis of the tibiotarsal joint in Norwegian Standardbred trotters. (21070284)
2010
11
Sacral osteochondrosis in two German Shepherd Dogs. (19489784)
2009
12
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
13
Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs. (18564254)
2008
14
The use of fresh allografts in osteochondrosis dissecans of the lateral femoral condyle. (16953349)
2006
15
Osteochondrosis associated with copper deficiency in a red deer herd in Norway. (15581144)
2004
16
Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosis. (14719712)
2004
17
Osteochondrosis of the occipital condyles and atlanto-occipital dysplasia in a Belgian horse. (14703085)
2003
18
Nutrition and osteochondrosis. (9463862)
1998
19
Osteochondrosis of the femur. (9463860)
1998
20
Radiologic case study. Tibia vara (osteochondrosis deformans tibiae). (8936537)
1996
21
Osteochondrosis in a pedigree Suffolk ram. (8650917)
1996
22
Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis. (8175922)
1994
23
Comparison of the diagnostic accuracy of positive-contrast arthrography and arthrotomy in evaluation of osteochondrosis lesions in the scapulohumeral joint in dogs. (8407466)
1993
24
Economic relevance, diagnosis, and countermeasures for degenerative joint disease (osteoarthrosis) and dyschondroplasia (osteochondrosis) in pigs. (2200764)
1990
25
Atypical osteochondrosis in a four-month-old foal. (3366111)
1988
26
Osteochondrosis of the temporomandibular joint presenting as an apparent parotid mass. (3605957)
1987
27
General and local [corrected] aetiologic factors in canine osteochondrosis. (3672862)
1987
28
Observation on the development of osteochondrosis in young rats. (3795864)
1986
29
Osteochondrosis of the tarsal cuneiforms. (3995827)
1985
30
Cervical osteochondrosis and disc herniation. Eighteen years' use of interbody fusion by Cloward's technique in 755 cases. (6711365)
1984
31
Osteochondrosis dissecans of the knee. Results of operative treatment in juveniles. (6712421)
1984
32
Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses. (7056680)
1982
33
Fusarium-induced osteochondrosis (tibial dyschondroplasia) in chickens. (7147613)
1982
34
Age related changes and osteochondrosis in swine articular and epiphyseal cartilage: light ane electron microscopy. (7260732)
1981
35
Osteochondrosis of the shoulder joint of the horse. (7214917)
1981
36
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
37
Osteochondrosis in the horse. II. Pathology. (233595)
1978
38
Osteochondrosis in domestic animals. Introduction. (233603)
1978
39
Osteochondrosis in domestic animals. I. Pathogenesis and pathology in pigs, horses, bulls, turkeys, and broilers, with comparative aspects on osteochondritis dissecans in man. (233590)
1978
40
Juvenile osteochondrosis. (271835)
1977
41
Osteochondrosis in the horse. (1110665)
1975
42
Osteochondrosis of the vertebrae in a dog. (5462583)
1970
43
TIBIA VARA (OSTEOCHONDROSIS DEFORMANS TIBIAE): A SURVEY OF SEVENTY-ONE CASES. (14213402)
1964
44
TIBIA VARA (OSTEOCHONDROSIS DEFORMANS TIBIAE OR BLOUNT'S DISEASE). TREATMENT AND FOLLOW-UP EXAMINATION. (14209243)
1964
45
Osteochondrosis of the capitellum (Panner's disease). Report of a case. (14456742)
1962
46
Osteochondrosis deformans juvenilis dorsi. (13770264)
1961
47
Osteochondrosis of the capitulum humeri (Panners' disease); report of a case. (13606439)
1958
48
Observations on the differential diagnosis and sequelae of juvenile vertebral osteochondrosis. (13228191)
1954
49
Tibia vara; (osteochondrosis deformans tibiae); a survey of 23 cases. (14923172)
1952
50
Preventive and conservative treatment of osteochondrosis dissecans. (14894212)
1951

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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Compounds for genes affiliated with Osteochondrosis

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Compounds related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1proliferin4310.2NR3C1, IGF2
2aminoglutethimide43 1211.2NR3C1, IGF2
3ag 10244310.2IGF2, IGF1
4cetrorelix43 28 1212.2IGF1, IGF2
52,4-dinitrophenol4310.2IGF1, IGF2
6nandrolone43 2411.2NR3C1, IGF1
7pegvisomant43 1211.2IGF2, IGF1
8eb 108943 5911.1IGF1, IGF2
9cortisone43 2411.1NR3C1, IGF1
10estrone sulfate43 2411.1IGF2, IGF1
11bromocriptine43 28 1212.1IGF2, IGF1
12dehydroepiandrosterone sulfate4310.1IGF2, IGF1
13progestins4310.0IGF2, NR3C1
14n-(4-hydroxyphenyl)retinamide4310.0IGF2, IGF1
152-deoxyglucose43 1211.0IGF2, IGF1
16octreotide43 59 28 1213.0IGF1, IGF2
17alginate4310.0OSM, IGF1
18c-peptide439.9IGF2, IGF1
19megestrol acetate439.9NR3C1, IGF2, IGF1
20dhea439.9NR3C1, IGF2, IGF1
214-hydroxytamoxifen439.9IGF1, IGF2, NR3C1
22progestin439.9IGF1, IGF2, NR3C1
23hydrocortisone43 2 59 1212.9IGF1, IGF2, NR3C1
24triiodothyronine439.8IGF2, IGF1
25dihydrotestosterone43 28 24 1212.8NR3C1, IGF2, IGF1
26phenobarbital43 28 49 1212.8NR3C1, IGF2
27etoposide43 49 59 1212.8NR3C1, IGF2, IGF1
28vitamin d439.8NR3C1, IGF2, IGF1
29rapamycin439.8IGF1, IGF2, NR3C1
30ly294002439.7NR3C1, IGF2, IGF1
31actinomycin d439.7IGF1, IGF2, NR3C1
32agar439.7IGF2, OSM, NR3C1
33androstenedione43 2410.7IGF2, IGF1
34glutamine439.7NR3C1, IGF2, IGF1
35glycosaminoglycan439.5MMP16, OSM, IGF2
36losartan43 49 28 1212.5IGF1, MMP16
37aprotinin43 1210.5IGF2, IGF1
38thymidine43 2410.4OSM, IGF2, IGF1
39acth439.4NR3C1, OSM, IGF2, IGF1
40estradiol43 24 1211.4NR3C1, OSM, IGF2, IGF1
41cycloheximide439.4IGF1, IGF2, OSM, NR3C1
42steroid439.4IGF1, IGF2, OSM, NR3C1
43dexamethasone43 49 28 1212.4NR3C1, OSM, IGF2, IGF1
44estrogen439.3IGF1, IGF2, OSM, NR3C1
45retinoic acid43 2410.3NR3C1, OSM, IGF2, IGF1
46vegf438.8IGF1, IGF2, OSM, MMP16, NR3C1

GO Terms for genes affiliated with Osteochondrosis

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Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.8IGF2, IGF1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1exocrine pancreas developmentGO:003101710.0IGF1, IGF2
2positive regulation of glycogen biosynthetic processGO:004572510.0IGF2, IGF1
3positive regulation of activated T cell proliferationGO:004210410.0IGF2, IGF1
4positive regulation of mitosisGO:00458409.9IGF2, IGF1
5positive regulation of cell divisionGO:00517819.8IGF2, OSM
6positive regulation of protein kinase B signalingGO:00518979.7IGF1, IGF2
7positive regulation of catalytic activityGO:00430859.6MMP16, IGF2
8positive regulation of MAPK cascadeGO:00434109.6OSM, IGF2, IGF1
9positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6OSM, IGF2, IGF1
10platelet degranulationGO:00025769.5IGF2, IGF1
11positive regulation of cell proliferationGO:00082849.3OSM, IGF2, IGF1
12cellular protein metabolic processGO:00442679.0GALNT13, IGF2, IGF1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.8IGF2, IGF1
2hormone activityGO:00051799.8IGF2, IGF1
3insulin receptor bindingGO:00051589.5IGF2, IGF1
4growth factor activityGO:00080839.2OSM, IGF2, IGF1

Products for genes affiliated with Osteochondrosis

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Sources for Osteochondrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet