MCID: OST016
MIFTS: 46

Osteochondrosis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteochondrosis

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Aliases & Descriptions for Osteochondrosis:

Name: Osteochondrosis 32 10 45 12 65
Osteochondritis Juvenilis 10 65
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 10
 
Juvenile Osteochondrosis of Tibial Tubercle 65
Epiphyseal Necrosis, Nos 10

Classifications:



External Ids:

Disease Ontology10 DOID:8125
ICD1027 M92, M93.9
ICD9CM29 732.6
MeSH36 D055034
NCIt42 C34879
UMLS65 C0029429, C0158445, C0729346

Summaries for Osteochondrosis

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Disease Ontology:10 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary: Osteochondrosis, also known as osteochondritis juvenilis, is related to osteonecrosis and legg-calve-perthes disease. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and EGFR Transactivation by Gastrin. Affiliated tissues include bone, bone and breast, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Wikipedia:68 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis25.7ACAN, COL2A1, IGF1, IGF2, IHH, KLHDC2
2legg-calve-perthes disease12.1
3scheuermann's disease12.1
4blount's disease11.9
5kohler's disease11.9
6osgood-schlatter's disease11.6
7sinding-larsen-johansson disease11.6
8panner disease11.6
9freiberg's disease11.4
10kienbock's disease11.2
11thiemann disease, familial form11.2
12upington disease10.4
13vagus nerve disease10.4IGF1, IGF2
14bacterial esophagitis10.4IGF1, IGF2
15fetal methimazole syndrome10.4IGF1, IGF2
16hypotrichosis10.4IGF1, IGF2
17growth hormone insensitivity, partial10.4IGF1, IGF2
18fatal infantile encephalomyopathy10.4IGF1, IGF2
19small intestinal sarcoma10.4IGF2, IHH
20cutaneous leiomyosarcoma10.4IGF2, IHH
21struma ovarii10.4IGF1, IGF2
22epileptic encephalopathy, early infantile, 110.3COL2A1, IGF1
23spindle cell hemangioma10.3IGF1, IGF2
24leukemia10.3
25leber congenital amaurosis 310.3ACAN, COL2A1
26cataract10.3ACAN, COL2A1
27endotheliitis10.2
28spinal canal intradural extramedullary neoplasm10.2COL2A1, IGF1, IGF2
29smed strudwick type10.2ACAN, COL2A1
30primary hypertrophic osteoarthropathy10.2IGF1, IGF2
31hepatic flexure cancer10.2IGF1, IGF2
32dental enamel hypoplasia10.2COL2A1, TBXAS1
33stickler syndrome10.2ACAN, COL2A1
34epidermolysis bullosa, pretibial10.2COL2A1, IHH
35myopathy with extrapyramidal signs10.2ACAN, COL2A1
36hepatitis10.1
37pharyngitis10.1
38cervicitis10.1
39retinitis10.1
40slc16a1-related hyperinsulinism10.1ACAN, COL2A1
41bone resorption disease10.1ACAN, COL2A1
42rheumatoid arthritis10.1
43lung cancer10.1
44kawasaki disease10.1
45arthritis10.1
46lymphoma10.1
47urethritis10.1
48prostatitis10.1
49ischemia10.1
50pancreatitis10.1

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms for Osteochondrosis

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Drugs & Therapeutics for Osteochondrosis

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Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AnestheticsPhase 2, Phase 3, Phase 17385
2Fibrin Tissue AdhesivePhase 2, Phase 3138
3
LidocaineapprovedPhase 1, Phase 21103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
4Sodium Channel BlockersPhase 1, Phase 21180
5Peripheral Nervous System AgentsPhase 1, Phase 218510
6Diuretics, Potassium SparingPhase 1, Phase 21445
7Central Nervous System DepressantsPhase 1, Phase 210016
8Anesthetics, LocalPhase 1, Phase 22347
9Anti-Arrhythmia AgentsPhase 1, Phase 22371
10AstragalusNutraceuticalPhase 1, Phase 248
11Calcium, Dietary4678

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral DefectsRecruitingNCT02423629Phase 4
2Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized TrialCompletedNCT00560664Phase 3
3The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage DefectsRecruitingNCT00891501Phase 2, Phase 3
4Comparison of Microfracture Treatment and CARTIPATCH® Chondrocyte Graft Treatment in Femoral Condyle LesionsTerminatedNCT00945399Phase 3
5Effectiveness of Dextrose Injection for Osgood-Schlatter DiseaseCompletedNCT01300754Phase 1, Phase 2
6OD-PHOENIX in Talus Osteochondral LesionNot yet recruitingNCT02736318Phase 1, Phase 2
7Prospective Study of Scheuermann's KyphosisCompletedNCT00738309
8Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
9Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
10Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionRecruitingNCT02289976
11Clinical Assessment of the Missouri Osteochondral Allograft Preservation System - MOPSRecruitingNCT02503228
12Osteochondritis Dissecans of the KneeEnrolling by invitationNCT01455987
13Comparison of Standard Fusion With "Topping Off"-System in Lumbar SpineNot yet recruitingNCT01224379
14Cytokine Profiles in SpondylodiscitisNot yet recruitingNCT02554227
15A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral DefectsTerminatedNCT01209390
16Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave TherapyWithdrawnNCT01631409
17Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the KneeWithdrawnNCT02308358

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel, PMIDs: 17515233, 17590152, 16510814

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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MalaCards organs/tissues related to Osteochondrosis:

33
Bone, Breast, Heart, T cells, Prostate, Bone marrow, Endothelial

FMA organs/tissues related to Osteochondrosis:

16
Bone

Animal Models for Osteochondrosis or affiliated genes

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MGI Mouse Phenotypes related to Osteochondrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.1COL2A1, IGF1, IGF2, IHH, MMP16
2MP:00053828.5COL2A1, IGF2, IHH, KLHDC2, MMP16
3MP:00053908.0COL2A1, IGF1, IGF2, IHH, MMP16, NCDN
4MP:00053857.4COL2A1, IGF1, IGF2, IHH, KLHDC2, NR3C1
5MP:00053787.4COL2A1, IGF1, IGF2, IHH, KLHDC2, MMP16
6MP:00107687.0COL2A1, IGF1, IGF2, IHH, KLHDC2, MMP16

Publications for Osteochondrosis

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Articles related to Osteochondrosis:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc. (26380114)
2015
2
Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. (25713418)
2015
3
Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae ) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. (25855021)
2015
4
A coal worker's pneumoconiosis diagnosed with endosonography. (25841573)
2015
5
Histologic grading based on counting poorly differentiated clusters in preoperative biopsy predicts nodal involvement and pTNM stage in colorectal cancer patients. (24289972)
2014
6
Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample. (23360725)
2013
7
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. (23633457)
2013
8
Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma. (23999969)
2013
9
Aging aggravates long-term renal ischemia-reperfusion injury in a rat model. (24238972)
2013
10
Screening tests for gestational diabetes: a systematic review for the U.S. Preventive Services Task Force. (23712349)
2013
11
Diabetic retinopathy at diagnosis of type 2 diabetes in the UK: a database analysis. (23052061)
2013
12
Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells. (24499623)
2013
13
Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. (22401962)
2012
14
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. (21911464)
2011
15
Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. (20709772)
2010
16
Unusual presentation of brain aspergillosis in chronic granulomatous disease. (21093739)
2010
17
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. (19129184)
2009
18
Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry. (18797853)
2008
19
Mast cell leukemia: a report of ten cases. (18172645)
2008
20
Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2. (17428670)
2007
21
Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis. (17620987)
2007
22
The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin. (17786215)
2007
23
Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. (17192493)
2007
24
Acute diarrhea in the adult horse: case example and review. (16627106)
2006
25
Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression. (16966332)
2006
26
Treatment of multiple giant molluscum contagiosum in a renal transplant patient with imiquimod 5% cream. (16681599)
2006
27
The effects of nitric oxide in acute lung injury. (16256443)
2005
28
Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations. (15810881)
2005
29
Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. (15102852)
2004
30
Primary mediastinal large B-cell lymphoma: a single-institution clinical study in Japan. (15239397)
2004
31
Immunohistochemical staining of protein kinase C isozymes (betaII and delta) is helpful to distinguish reactive follicles from follicular colonization of MALT lymphoma. (14691723)
2004
32
The evidence base for shaken baby syndrome. (15044267)
2004
33
Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). (12893755)
2003
34
Phenotypic gender differences in subjects with familial partial lipodystrophy (Dunnigan variety) due to a nuclear lamin A/C R482W mutation. (12669268)
2003
35
Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. (11859078)
2002
36
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
37
A long-term coculture model for the study of mast cell-keratinocyte interactions. (12190864)
2002
38
Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (11925108)
2002
39
Down-regulation of human papillomavirus E6/E7 oncogene by arsenic trioxide in cervical carcinoma cells. (12430174)
2002
40
Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells. (12209971)
2002
41
Thrombosed hemodialysis grafts: lyse and wait with tissue plasminogen activator or urokinase compared to mechanical thrombolysis with the Arrow-Trerotola Percutaneous Thrombolytic Device. (11585881)
2001
42
Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report. (9692002)
1998
43
Genitoanocrural porokeratosis following chronic exposure to benzene. (9667106)
1998
44
Drug treatment of prostatic carcinoma]. (9545743)
1997
45
Pancreatic cancer in rats and hamsters does not induce IAPP-related hyperglycaemia. (9259404)
1997
46
Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone. (9093187)
1997
47
Xenograft model of progressive human proliferative breast disease. (8411256)
1993
48
No germline TP53 mutations detected in familial and bilateral testicular cancer. (7680893)
1993
49
Antigen expression of frozen platelets. (1633681)
1992
50
Surgical palliation for endomyocardial fibrosis. (6695359)
1984

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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GO Terms for genes affiliated with Osteochondrosis

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Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycogen biosynthetic processGO:004572510.5IGF1, IGF2
2response to nutrient levelsGO:003166710.3IGF1, IGF2
3collagen fibril organizationGO:003019910.2ACAN, COL2A1
4proteoglycan biosynthetic processGO:003016610.0ACAN, IGF1
5memoryGO:000761310.0IGF1, IGF2
6extracellular matrix organizationGO:00301989.1ACAN, COL2A1, MMP16
7extracellular matrix disassemblyGO:00226178.9ACAN, COL2A1, MMP16

Sources for Osteochondrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet