MCID: OST016
MIFTS: 50

Osteochondrosis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteochondrosis

Aliases & Descriptions for Osteochondrosis:

Name: Osteochondrosis 38 12 50 14 69
Osteochondritis Juvenilis 12 69
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 12
Juvenile Osteochondrosis of Tibial Tubercle 69
Epiphyseal Necrosis, Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8125
ICD10 33 M92 M93.9
ICD9CM 35 732.6
MeSH 42 D055034
NCIt 47 C34879

Summaries for Osteochondrosis

Disease Ontology : 12 An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary : Osteochondrosis, also known as osteochondritis juvenilis, is related to legg-calve-perthes disease and kohler's disease, and has symptoms including arthralgia and joint swelling. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Proteoglycans in cancer and Interleukin-4 and 13 signaling. The drugs Anesthetics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 legg-calve-perthes disease 11.9
2 kohler's disease 11.7
3 scheuermann disease 11.7
4 panner disease 11.7
5 blount's disease 11.6
6 osgood-schlatter's disease 11.4
7 kienbock's disease 11.1
8 sinding-larsen-johansson disease 11.1
9 freiberg's disease 10.9
10 thiemann disease 10.7
11 lacrimal duct obstruction 10.2 IGF1 IGF2
12 noonan syndrome 4 10.2 CD36 TGFB1
13 epileptic encephalopathy, early infantile, 24 10.2 IGF1 IGF2
14 osteochondritis dissecans 10.2
15 femur bifid with monodactylous ectrodactyly 10.2 CD36 IGF1 IGF2
16 lichen disease 10.1 IGF1 NR3C1 TGFB1
17 leber congenital amaurosis 10.1 CD36 TGFB1
18 deafness, autosomal recessive 74 10.1 IGF1 IGF2
19 hypotrichosis 8 10.1 IGF1 IGF2 TGFB1
20 gastric leiomyosarcoma 10.1 IGF2 IHH
21 prostate leiomyosarcoma 10.1 IGF2 IHH
22 epiphyseal dysplasia, multiple, with myopia and deafness 10.1 CD36 COL2A1
23 cervicitis 10.1
24 long qt syndrome 1 10.0 CD36 IHH
25 speech and communication disorders 10.0 CD36 TGFB1
26 carnitine deficiency, systemic primary 10.0 CD36 IGF1 NR3C1 TGFB1
27 bone angioendothelial sarcoma 10.0 COL2A1 TBXAS1 TGFB1
28 osteoarthritis 10.0
29 chromosomal disease 9.9 COL2A1 KLHDC2 TBXAS1
30 sacral agenesis with vertebral anomalies 9.9
31 upington disease 9.9
32 spondylosis 9.8
33 insulin-like growth factor i 9.8
34 nephrocalcinosis 9.7
35 osteoporosis 9.7
36 ischemia 9.7
37 chronic pain 9.7
38 spinal stenosis 9.7
39 scoliosis 9.7
40 osteomyelitis 9.7
41 ovarian insufficiency, familial 8.3 CD36 COL2A1 IGF1 IGF2 IHH KLHDC2

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to Osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

UMLS symptoms related to Osteochondrosis:


arthralgia, joint swelling

GenomeRNAi Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.58 SEMA3D
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.58 CD36
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 NR3C1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 NR3C1 SEMA3D CD36
5 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 NR3C1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 CD36 NR3C1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 CD36
8 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.58 CD36
9 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.58 CD36
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 CD36
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 CD36
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 SEMA3D
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.58 SEMA3D
14 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.58 NR3C1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.58 SEMA3D
16 Decreased viability with paclitaxel GR00179-A-1 9.26 IGF1 TGFB1
17 Decreased viability with paclitaxel GR00179-A-2 9.26 IGF1
18 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Osteochondrosis:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 NR3C1 SEMA3D TGFB1 XIRP2 CD36 COL2A1
2 behavior/neurological MP:0005386 10.21 CD36 COL2A1 IGF2 KLHDC2 MMP16 NR3C1
3 growth/size/body region MP:0005378 10.21 CD36 COL2A1 IGF1 IGF2 IHH KLHDC2
4 homeostasis/metabolism MP:0005376 10.15 CD36 COL2A1 IGF1 IGF2 NR3C1 OSM
5 mortality/aging MP:0010768 10.1 KLHDC2 MMP16 NR3C1 TGFB1 XIRP2 CD36
6 immune system MP:0005387 10.08 TBXAS1 TGFB1 CD36 COL2A1 IGF1 IGF2
7 digestive/alimentary MP:0005381 10.07 CD36 COL2A1 IGF2 IHH MMP16 NR3C1
8 craniofacial MP:0005382 10.01 COL2A1 IGF2 IHH KLHDC2 MMP16 TGFB1
9 adipose tissue MP:0005375 9.97 CD36 COL2A1 IGF1 NR3C1 TGFB1
10 nervous system MP:0003631 9.92 CD36 COL2A1 IGF1 IGF2 IHH NR3C1
11 liver/biliary system MP:0005370 9.91 CD36 COL2A1 IGF2 NR3C1 TGFB1 XIRP2
12 muscle MP:0005369 9.91 CD36 IGF1 IGF2 IHH NR3C1 TGFB1
13 limbs/digits/tail MP:0005371 9.85 COL2A1 IGF1 IGF2 IHH MMP16
14 renal/urinary system MP:0005367 9.73 CD36 COL2A1 IGF1 IGF2 NR3C1 TGFB1
15 respiratory system MP:0005388 9.63 COL2A1 IGF1 IGF2 IHH NR3C1 TGFB1
16 skeleton MP:0005390 9.56 CD36 COL2A1 IGF1 IGF2 IHH MMP16
17 vision/eye MP:0005391 9.1 CD36 COL2A1 IGF2 IHH KLHDC2 TGFB1

Drugs & Therapeutics for Osteochondrosis

Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2, Phase 3,Phase 1
2 Fibrin Tissue Adhesive Phase 2, Phase 3
3
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
4 Sodium Channel Blockers Phase 1, Phase 2
5 Diuretics, Potassium Sparing Phase 1, Phase 2
6 Peripheral Nervous System Agents Phase 1, Phase 2
7 Anesthetics, Local Phase 1, Phase 2
8 Anti-Arrhythmia Agents Phase 1, Phase 2
9 Central Nervous System Depressants Phase 1, Phase 2
10 Calcium, Dietary
11 Astragalus Nutraceutical

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects Recruiting NCT02423629 Phase 4
2 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
3 Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial Completed NCT00560664 Phase 3
4 Treatment of the Osgood Schlatter Recruiting NCT02824172 Phase 3
5 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
6 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379
7 Osteochondritis Dissecans of the Knee Unknown status NCT01455987
8 Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression Unknown status NCT02289976
9 Prospective Study of Scheuermann's Kyphosis Completed NCT00738309
10 Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. Recruiting NCT02799394
11 Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee Recruiting NCT01754298
12 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Recruiting NCT02397278
13 ReNu™ Marrow Stimulation Augmentation Recruiting NCT03036878
14 Cytokine Profiles in Spondylodiscitis Recruiting NCT02554227
15 A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral Defects Terminated NCT01209390
16 Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee Withdrawn NCT02308358
17 Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Withdrawn NCT01631409

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel PMIDs: 17515233 17590152 16510814

Genetic Tests for Osteochondrosis

Anatomical Context for Osteochondrosis

MalaCards organs/tissues related to Osteochondrosis:

39
Bone, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Osteochondrosis:

18
Bone

Publications for Osteochondrosis

Articles related to Osteochondrosis:

(show top 50) (show all 408)
id Title Authors Year
1
Direct comparison of different surgical approaches in a woman with bilateral osteochondrosis dissecans of her knees: a case report. ( 26786243 )
2016
2
Candidate gene analysis of osteochondrosis in Spanish Purebred horses. ( 27422688 )
2016
3
Identification and validation of risk loci for osteochondrosis in standardbreds. ( 26753841 )
2016
4
Vitamin D Deficiency: The Missing Etiological Factor in the Development of Juvenile Osteochondrosis Dissecans? ( 28009798 )
2016
5
Osteochondrosis prevalence and severity at 12 and 24 weeks of age in commercial pigs with and without organic-complexed trace mineral supplementation. ( 27898885 )
2016
6
The development of locomotor kinetics in the foal and the effect of osteochondrosis. ( 27859501 )
2016
7
Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis-susceptible sites in foals revealed by SWI 3T MRI. ( 26740060 )
2016
8
Preliminary report on osteochondrosis in cattle in the north-western parts of South Africa. ( 27543146 )
2016
9
Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second-harmonic microscopy, and histological findings. ( 27734566 )
2016
10
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. ( 27283998 )
2016
11
Prevalence of humeral head osteochondrosis in the Greater Swiss Mountain dog and the Border Collie in Switzerland. ( 27821378 )
2016
12
Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses. ( 27448988 )
2016
13
Osteochondrosis dissecans of the temporomandibular joint: a case report and a review of literature. ( 27142101 )
2016
14
Prevalence and characteristics of osteochondrosis in 309 Spanish Purebred horses. ( 26670332 )
2016
15
Impact of feeding and housing on the development of osteochondrosis in foals-A longitudinal study. ( 27094134 )
2016
16
OSTEOCHONDROSIS IN THE DISTAL FEMURS OF AN ADULT RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS RETICULATA): MACROSCOPIC, RADIOLOGIC, AND HISTOLOGIC FINDINGS. ( 27010303 )
2016
17
Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis. ( 25463443 )
2015
18
Dissolution of the capitellum after nondisplaced supracondylar fracture of the humerus in a child: a case report of transient osteochondrosis. ( 25647568 )
2015
19
Osteochondrosis of the accessory ossification centre of the medial malleolus. ( 25438106 )
2015
20
Identification of novel osteochondrosis- associated genes. ( 26296056 )
2015
21
Age-dependent expression of osteochondrosis-related genes in equine leukocytes. ( 26392886 )
2015
22
Osteochondrosis, but not lameness, is more frequent among free-range pigs than confined herd-mates. ( 26416598 )
2015
23
Associations of conformation and locomotive characteristics in growing gilts with osteochondrosis at slaughter. ( 25568360 )
2015
24
Wnt/ I^-catenin signaling of cartilage canal and osteochondral junction chondrocytes and full thickness cartilage in early equine osteochondrosis. ( 25676127 )
2015
25
Bilateral osteochondrosis of the distal tibial epiphysis: a case report. ( 25504104 )
2015
26
Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model. ( 26473611 )
2015
27
An Update on the Pathogenesis of Osteochondrosis. ( 26080832 )
2015
28
Osteochondrosis of the inferior pole of the scapula (Roca disease). ( 23838852 )
2014
29
Arthroscopic assessment of osteochondrosis of the medial humeral condyle treated with debridement and sliding humeral osteotomy. ( 25109907 )
2014
30
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses. ( 25428408 )
2014
31
Short- and long-term racing performance of Standardbred pacers and trotters after early surgical intervention for tarsal osteochondrosis. ( 24819047 )
2014
32
Ossification defects detected in CT scans represent early osteochondrosis in the distal femur of piglets. ( 24740876 )
2014
33
Omics technologies provide new insights into the molecular physiopathology of equine osteochondrosis. ( 25359417 )
2014
34
DIAGNOSTIC SENSITIVITY OF RADIOGRAPHY, ULTRASONOGRAPHY, AND MAGNETIC RESONANCE IMAGING FOR DETECTING SHOULDER OSTEOCHONDROSIS/OSTEOCHONDRITIS DISSECANS IN DOGS. ( 24844132 )
2014
35
Heritability estimates of tarsocrural osteochondrosis and palmar/plantar first phalanx osteochondral fragments in Standardbred trotters. ( 23448227 )
2014
36
Genetic trends of conformation traits and genetic correlations to osteochondrosis in boars. ( 24816139 )
2014
37
Osteochondrosis of the capitellum of the humerus (Panner's disease, Osteochondritis Dissecans). Case study. ( 24728797 )
2014
38
Treatment of Osteochondrosis Dissecans in the Stifle and Tarsus of Juvenile Thoroughbred Horses. ( 25243728 )
2014
39
Bilateral osteochondrosis of the primary patellar ossification centers in a young athlete: a case report. ( 23797161 )
2014
40
The influence of floor type before and after 10 weeks of age on osteochondrosis in growing gilts. ( 24987085 )
2014
41
Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. ( 25227120 )
2014
42
Consequences of the natural course of articular osteochondrosis in pigs for the suitability of computed tomography as a screening tool. ( 25199991 )
2014
43
Diagnostic sensitivity and interobserver agreement of radiography and ultrasonography for detecting trochlear ridge osteochondrosis lesions in the equine stifle. ( 23278908 )
2013
44
Biotechnical measurement and software system for the prediction and diagnosis of osteochondrosis of the lumbar region with the use of fuzzy logic rules. ( 23370903 )
2013
45
Surgical versus conservative management of osteochondrosis. ( 23746868 )
2013
46
Tissue mineral concentrations and osteochondrosis lesions in prolific sows across parities 0 through 7. ( 23296836 )
2013
47
The influence of dietary restriction before and after 10 weeks of age on osteochondrosis in growing gilts. ( 23989871 )
2013
48
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. ( 23238225 )
2013
49
Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans. ( 23428601 )
2013
50
IHH gene polymorphism among three horse breeds and its application for association test in horses with osteochondrosis. ( 23865964 )
2013

Variations for Osteochondrosis

Expression for Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for Osteochondrosis

GO Terms for Osteochondrosis

Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 COL2A1 IGF1 IGF2 IHH MMP16 OSM
2 proteinaceous extracellular matrix GO:0005578 9.46 COL2A1 IHH MMP16 TGFB1
3 extracellular space GO:0005615 9.23 CD36 COL2A1 IGF1 IGF2 IHH OSM
4 platelet alpha granule lumen GO:0031093 9.13 IGF1 IGF2 TGFB1

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.98 IGF1 IHH NR3C1 OSM TGFB1
2 positive regulation of cell proliferation GO:0008284 9.88 IGF1 IGF2 OSM TGFB1
3 regulation of gene expression GO:0010468 9.78 COL2A1 IGF1 TGFB1
4 cellular response to dexamethasone stimulus GO:0071549 9.6 NR3C1 TGFB1
5 protein kinase B signaling GO:0043491 9.59 IGF1 TGFB1
6 positive regulation of activated T cell proliferation GO:0042104 9.57 IGF1 IGF2
7 endochondral ossification GO:0001958 9.56 COL2A1 MMP16
8 skeletal system development GO:0001501 9.56 COL2A1 IGF1 IGF2 IHH
9 positive regulation of mitotic nuclear division GO:0045840 9.55 IGF1 IGF2
10 positive regulation of collagen biosynthetic process GO:0032967 9.54 IHH TGFB1
11 positive regulation of epithelial cell proliferation GO:0050679 9.54 IGF1 IHH TGFB1
12 cell-cell junction organization GO:0045216 9.52 TGFB1 XIRP2
13 response to fatty acid GO:0070542 9.51 CD36 TBXAS1
14 positive regulation of cell division GO:0051781 9.5 IGF2 OSM TGFB1
15 cell activation GO:0001775 9.49 IGF1 TGFB1
16 positive regulation of glycogen biosynthetic process GO:0045725 9.48 IGF1 IGF2
17 positive regulation of transcription regulatory region DNA binding GO:2000679 9.46 IGF1 TGFB1
18 platelet degranulation GO:0002576 9.46 CD36 IGF1 IGF2 TGFB1
19 chondrocyte proliferation GO:0035988 9.43 IHH MMP16
20 proteoglycan metabolic process GO:0006029 9.4 COL2A1 IHH
21 positive regulation of MAPK cascade GO:0043410 9.26 CD36 IGF1 IGF2 OSM
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.02 CD36 IGF1 IGF2 OSM TGFB1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 IGF1 IGF2
2 protein serine/threonine kinase activator activity GO:0043539 9.16 IGF2 TGFB1
3 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 IGF2
4 growth factor activity GO:0008083 8.92 IGF1 IGF2 OSM TGFB1

Sources for Osteochondrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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