MCID: OST016
MIFTS: 51

Osteochondrosis malady

Bone diseases category

Summaries for Osteochondrosis

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards: Osteochondrosis, also known as osteochondritis juvenilis, is related to osteoarthritis and legg-calve-perthes disease. An important gene associated with Osteochondrosis is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Endochondral Ossification. The compounds proliferin and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotype skeleton.

Wikipedia:63 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Aliases & Classifications for Osteochondrosis

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Sources:
60UMLS, 8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteochondrosis 8 10 30
osteochondritis juvenilis 8 60
juvenile osteochondrosis of tibial tubercle 60
osteochondrosis not specified as adult 8
juvenile, of unspecified site 8
epiphyseal necrosis, nos 8
osteochondritis nos 8
osteochondrosis nos 8
epiphysitis nos 8
apophysitis nos 8


External Ids:

Disease Ontology8 DOID:8125
MeSH34 D055034
NCIt39 C34879

Related Diseases for Osteochondrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1osteoarthritis30.1OSM, NR3C1, IGF1, ACAN
2legg-calve-perthes disease10.4
3osteochondritis dissecans10.3
4blount's disease10.3
5osgood-schlatter's disease10.2
6scheuermann's disease10.2
7cervicitis10.2
8kohler's disease10.2
9sinding-larsen-johansson disease10.2
10freiberg's disease10.1
11familial scheuermann disease10.1
12panner disease10.1
13fibrosarcoma10.0OSM
14retinoblastoma10.0OSM
15pulmonary fibrosis10.0OSM
16spondylosis10.0
17osteopoikilosis10.0
18achondrogenesis type ib10.0
19metaphyseal dysplasia10.0
20stickler syndrome type 110.0
21kienbock's disease10.0
22sialidosis type i10.0
23upington disease10.0
24thanatophoric dysplasia type 110.0
25mucopolysaccharidosis ih10.0
26osteochondritis of tarsal/metatarsal bone10.0
27thiemann disease, familial form10.0
28fetal macrosomia10.0IGF2
29arthropathy10.0OSM, ACAN
30chronic fatigue syndrome10.0NR3C1
31cushing's syndrome10.0NR3C1
32arthritis10.0ACAN, OSM
33insulin-like growth factor 1 resistance to10.0IGF2, IGF1
34laron syndrome10.0IGF2, IGF1
35panhypopituitarism10.0IGF1
36pituitary adenoma10.0NR3C1, IGF1
37rheumatoid arthritis10.0OSM, NR3C1, ACAN
38growth retardation-mild developmental delay-chronic hepatitis syndrome10.0IGF1, IGF2
39hypertrophy of breast10.0OSM, IGF2, IGF1, ACAN
40hyperandrogenism10.0NR3C1, IGF2, IGF1
41bone fracture9.8
42neurofibromatosis9.8
43sjogren-larsson syndrome9.8
44fucosidosis9.8
45hajdu-cheney syndrome9.8
46mccune albright syndrome9.8
47spondyloepiphyseal dysplasia congenita9.8
48cartilage-hair hypoplasia9.8
49achondroplasia9.8
50camurati-engelmann disease9.8

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Clinical Features for Osteochondrosis

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Drugs & Therapeutics for Osteochondrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Osteochondrosis

Drug clinical trials:

Search ClinicalTrials for Osteochondrosis

Search NIH Clinical Center for Osteochondrosis

Search CenterWatch for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteochondrosis:

32
Bone, Testes

FMA organs/tissues related to Osteochondrosis:

14
Bone

Animal Models for Osteochondrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Osteochondrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.4ACAN, MMP16, IGF1, IGF2, NR3C1, NCDN

Publications for Osteochondrosis

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Sources:
50PubMed
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Articles related to Osteochondrosis:

(show top 50)    (show all 369)
idTitleAuthorsYear
1
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
2
Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans. (23428601)
2013
3
Heritabilities and genetic correlations between fetlock, hock and stifle osteochondrosis and fetlock osteochondral fragments in Hanoverian Warmblood horses. (24236645)
2013
4
Problems and pointers in osteochondrosis: Twenty years on. (23639371)
2013
5
Biochemical evaluation of articular cartilage in patients with osteochondrosis dissecans by means of quantitative T2- and T2-mapping at 3T MRI: a feasibility study. (21392912)
2012
6
Refinement of a quantitative trait locus on equine chromosome 5 responsible for fetlock osteochondrosis in Hanoverian warmblood horses. (19392821)
2009
7
Micro-computed tomography of early lesions of osteochondrosis in the tarsus of foals. (18579463)
2008
8
Epiphyseal cartilage canal blood supply to the tarsus of foals and relationship to osteochondrosis. (18083657)
2008
9
Associations between candidate gene markers at a quantitative trait locus on equine chromosome 4 responsible for osteochondrosis dissecans in fetlock joints of South German Coldblood horses. (18227080)
2008
10
Etiology and pathogenesis of osteochondrosis. (17606505)
2007
11
Identification of infrared absorption spectral characteristics of synovial fluid of horses with osteochondrosis of the tarsocrural joint. (17472451)
2007
12
Osteochondrosis and copper: histology of articular cartilage from foals out of copper supplemented and non-supplemented dams. (16314126)
2007
13
Characterizing osteochondrosis in the dog: potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression. (15727889)
2005
14
Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures. (16334944)
2005
15
Effect of medical and biological factors on neurological manifestations of vertebral osteochondrosis in residents of the southern Altai Mountains. (12910294)
2003
16
Osteochondrosis of the sacral bone in a mastiff dog. (9829306)
1998
17
Osteochondrosis in wild boar-Swedish Yorkshire crossbred pigs (F2 generation). (7572457)
1995
18
Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis. (8175922)
1994
19
Bilateral osteochondrosis of the distal epiphysis. A case report. (8443365)
1993
20
Heritability estimations of osteochondrosis in the tibiotarsal joint and of bony fragments in the palmar/plantar portion of the metacarpo- and metatarsophalangeal joints of horses. (8407439)
1993
21
Dyschondroplasia (osteochondrosis) in articular-epiphyseal cartilage complexes of three calves from 24 to 103 days of age. (1448908)
1992
22
Deformation of the distal femur: a contribution towards the pathogenesis of osteochondrosis dissecans in the knee joint. (1856242)
1991
23
Osteochondrosis of the tibial tuberosity (Osgood-Schlatter's disease) (2769094)
1989
24
Degeneration of cartilage canal vessels associated with lesions of osteochondrosis in swine. (2913703)
1989
25
Osteochondrosis. (3413947)
1988
26
Morphological investigation of osteochondrosis induced by ofloxacin in rats. (3209010)
1988
27
Osteochondrosis: a new problem for the profession? (3413925)
1988
28
Acetabular osteochondrosis dissecans in a foal. (3802831)
1987
29
Arthroscopy update #1. Treatment of osteochondrosis dissecans of the knee by arthroscopic curettage, follow-up study. (3453907)
1986
30
Osteochondrosis of the tarsal cuneiforms. (3995827)
1985
31
Dyschondroplasias of growth cartilages (osteochondrosis) in crossbred commercial pigs at one and 15 days of age: radiological, angiomicrographical and histological findings. (3976139)
1985
32
Osteochondrosis dissecans of the knee. Results of operative treatment in juveniles. (6712421)
1984
33
Dyschondroplasias, including osteochondrosis, in boars between 25 and 169 days of age: radiologic changes. (6732024)
1984
34
Radiological investigations of osteochondrosis dissecans in Standardbred Trotters and Swedish Warmblood horses. (6489302)
1984
35
Osteochondrosis in feedlot cattle. (7257092)
1981
36
Osteochondrosis of the shoulder joint of the horse. (7214917)
1981
37
Osteochondrosis and arthrosis in Norwegian slaughter-pigs in 1980 compared to 1970. (7329782)
1981
38
Osteochondrosis dissecans. (7273527)
1981
39
Osteochondrosis of the elbow joint in young dogs. (7453149)
1980
40
Arthroscopy in the evaluation of operative treatment of osteochondrosis dissecans. (460841)
1979
41
Osteochondrosis in domestic animals. Introduction. (233603)
1978
42
Morphology of osteochondrosis and sequelae in pigs. (233602)
1978
43
Tibial dyschondroplasia (osteochondrosis) in the turkey. A morphologic investigation. (233597)
1978
44
Osteochondrosis dissecans of the head of the humerus in two foals. (923550)
1977
45
Osteochondrosis of the shoulder and stifle in 3 of 5 Border Collie littermates. (830632)
1977
46
Osteochondrosis and arthrosis in pigs. VI. Relationship to feed level and calcium phosphorus and protein levels in the ration. (4853501)
1974
47
Osteochondrosis deformans juvenilis dorsi. (13770264)
1961
48
Preventive and conservative treatment of osteochondrosis dissecans. (14894212)
1951
49
Osteochondrosis of the intervertebral discs. (14809136)
1951
50
The osteochondrosis. (18122578)
1948

Genetic Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteochondrosis

Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Osteochondrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IGF1, IGF2
29.7IGF2, IGF1, ACAN
39.5IGF1, NR3C1, OSM
4
Cell adhesion ECM remodeling
Hide members
9.1ACAN, MMP16, IGF1, IGF2

Compounds for genes affiliated with Osteochondrosis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Osteochondrosis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1proliferin4410.2IGF2, NR3C1
2ag 10244410.2IGF1, IGF2
3nandrolone44 2411.2IGF1, NR3C1
4aminoglutethimide44 1111.1IGF2, NR3C1
52,4-dinitrophenol4410.1IGF1, IGF2
6cetrorelix44 28 1112.1IGF1, IGF2
7pegvisomant44 1111.1IGF2, IGF1
8megestrol acetate4410.0IGF1, IGF2, NR3C1
9dhea449.9NR3C1, IGF2, IGF1
104-hydroxytamoxifen449.9IGF1, IGF2, NR3C1
11alginate449.9OSM, IGF1, ACAN
12progestin449.9NR3C1, IGF2, IGF1
13cortisone44 2410.9IGF1, NR3C1
14hydrocortisone44 2 59 1112.7NR3C1, IGF2, IGF1
15vitamin d449.7ACAN, IGF1, IGF2, NR3C1
16acth449.6IGF1, IGF2, NR3C1, OSM
17dihydrotestosterone44 28 11 2412.5NR3C1, IGF2, IGF1
18glycosaminoglycan449.3ACAN, MMP16, IGF2, OSM
19tgf beta1449.3ACAN, IGF2, OSM
20dexamethasone44 49 28 1112.3OSM, NR3C1, IGF2, IGF1, ACAN
21estradiol44 11 2411.3IGF1, IGF2, NR3C1, OSM
22vegf448.7MMP16, IGF1, IGF2, NR3C1, OSM

GO Terms for genes affiliated with Osteochondrosis

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16Gene Ontology
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Biological processes related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.9IGF1, IGF2
2positive regulation of glycogen biosynthetic processGO:0457259.8IGF2, IGF1
3positive regulation of MAPK cascadeGO:0434109.6IGF1, IGF2, OSM
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IGF1, IGF2, OSM
5skeletal system developmentGO:0015019.4ACAN, IGF1, IGF2

Molecular functions related to Osteochondrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.6IGF1, IGF2
2growth factor activityGO:0080839.5IGF1, IGF2, OSM

Products for genes affiliated with Osteochondrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteochondrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet