MCID: OST016
MIFTS: 50

Osteochondrosis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteochondrosis

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Aliases & Descriptions for Osteochondrosis:

Name: Osteochondrosis 34 11 47 13 67
Osteochondritis Juvenilis 11 67
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 11
 
Juvenile Osteochondrosis of Tibial Tubercle 67
Epiphyseal Necrosis, Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:8125
ICD1029 M92, M93.9
ICD9CM31 732.6
MeSH38 D055034
NCIt44 C34879

Summaries for Osteochondrosis

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Disease Ontology:11 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary: Osteochondrosis, also known as osteochondritis juvenilis, is related to legg-calve-perthes disease and kohler's disease, and has symptoms including arthralgia and joint swelling. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and EGFR Transactivation by Gastrin. Affiliated tissues include bone, bone and bone marrow, and related mouse phenotypes are adipose tissue and respiratory system.

Wikipedia:70 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1legg-calve-perthes disease11.9
2kohler's disease11.7
3scheuermann disease11.7
4panner disease11.7
5blount's disease11.6
6osgood-schlatter's disease11.4
7kienbock's disease11.1
8sinding-larsen-johansson disease11.1
9freiberg's disease10.9
10thiemann disease10.7
11necrotizing ulcerative gingivitis10.5IGF1, IGF2
12hallux varus and preaxial polysyndactyly10.5IGF1, IGF2
13congenital methemoglobinemia10.5CD36, TGFB1
14growth hormone insensitivity, partial10.5IGF1, IGF2
15keratopathy10.5CD36, TGFB1
16fibrosclerosis of breast10.4IGF1, TGFB1
17fibromatosis, gingival, 110.4CD36, TGFB1
18fetal methyl mercury syndrome10.4IGF1, IGF2
19kartagener syndrome10.4IGF1, IGF2
20splenic artery aneurysm10.3IGF1, IGF2
21multiple mitochondrial dysfunctions syndrome10.3CD36, IGF1, IGF2
22pyoderma gangrenosum10.3IGF1, NR3C1, TGFB1
23perivascular epithelioid cell tumor10.3IGF1, IGF2
24bone marrow cancer10.3IGF1, IGF2
25lissencephaly, x-linked 210.3COL2A1, IGF1
26small cell cancer of the lung, somatic10.2IGF1, IGF2, TGFB1
27cutaneous leiomyosarcoma10.2IGF2, IHH
28malignant dermis tumor10.2IGF2, IHH
29smed strudwick type10.2CD36, COL2A1
30osteochondritis dissecans10.2
31leukemia10.1IGF1, TGFB1
32papillary extrahepatic bile duct adenocarcinoma10.1COL2A1, TBXAS1
33cervicitis10.1
34chylomicron retention disease10.0CD36, IGF1, NR3C1, TGFB1
35osteoarthritis10.0
36xanthomatosis9.9COL2A1, TBXAS1, TGFB1
37sacral agenesis with vertebral anomalies9.9
38upington disease9.9
39insulin-like growth factor i9.8
40spondylosis9.8
41osteoporosis9.7
42spinal stenosis9.7
43scoliosis9.7
44osteomyelitis9.7
45nephrocalcinosis9.7
46ischemia9.7
47chronic pain9.7
48toenail dystrophy, isolated9.5COL2A1, IHH
49bone resorption disease9.4COL2A1, KLHDC2, SEMA3D, TBXAS1
50osteopetrosis6.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms for Osteochondrosis

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UMLS symptoms related to Osteochondrosis:


arthralgia, joint swelling

Drugs & Therapeutics for Osteochondrosis

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Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AnestheticsPhase 2, Phase 3, Phase 19001
2Fibrin Tissue AdhesivePhase 2, Phase 3145
3
Lidocaineapproved, vet_approvedPhase 1, Phase 21226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
4Sodium Channel BlockersPhase 1, Phase 21515
5Peripheral Nervous System AgentsPhase 1, Phase 222776
6Diuretics, Potassium SparingPhase 1, Phase 21827
7Central Nervous System DepressantsPhase 1, Phase 212806
8Anesthetics, LocalPhase 1, Phase 23272
9Anti-Arrhythmia AgentsPhase 1, Phase 22969
10Calcium, Dietary5525
11AstragalusNutraceutical52

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral DefectsRecruitingNCT02423629Phase 4
2The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage DefectsUnknown statusNCT00891501Phase 2, Phase 3
3Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized TrialCompletedNCT00560664Phase 3
4Treatment of the Osgood SchlatterRecruitingNCT02824172Phase 3
5Effectiveness of Dextrose Injection for Osgood-Schlatter DiseaseCompletedNCT01300754Phase 1, Phase 2
6Comparison of Standard Fusion With "Topping Off"-System in Lumbar SpineUnknown statusNCT01224379
7Osteochondritis Dissecans of the KneeUnknown statusNCT01455987
8Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionUnknown statusNCT02289976
9Prospective Study of Scheuermann's KyphosisCompletedNCT00738309
10Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
11Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
12Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease.Not yet recruitingNCT02799394
13Cytokine Profiles in SpondylodiscitisNot yet recruitingNCT02554227
14A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral DefectsTerminatedNCT01209390
15Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the KneeWithdrawnNCT02308358
16Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave TherapyWithdrawnNCT01631409

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel, PMIDs: 17515233, 17590152, 16510814

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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MalaCards organs/tissues related to Osteochondrosis:

35
Bone, Bone marrow, Testes

FMA organs/tissues related to Osteochondrosis:

17
Bone

Animal Models for Osteochondrosis or affiliated genes

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MGI Mouse Phenotypes related to Osteochondrosis:

40 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2CD36, COL2A1, IGF1, NR3C1, TGFB1
2MP:00053889.0COL2A1, IGF1, IGF2, IHH, NR3C1, TGFB1
3MP:00053719.0COL2A1, IGF1, IGF2, IHH, MMP16
4MP:00053678.9CD36, COL2A1, IGF1, IGF2, NR3C1, TGFB1
5MP:00053708.9CD36, COL2A1, IGF2, NR3C1, TGFB1, XIRP2
6MP:00107718.7IGF1, IGF2, NR3C1, OSM, TGFB1, XIRP2
7MP:00053698.5CD36, IGF1, IGF2, IHH, NR3C1, TGFB1
8MP:00053918.3CD36, COL2A1, IGF2, IHH, KLHDC2, TGFB1
9MP:00053878.1CD36, COL2A1, IGF1, IGF2, NR3C1, OSM
10MP:00053818.1CD36, COL2A1, IGF2, IHH, MMP16, NR3C1
11MP:00053908.0CD36, COL2A1, IGF1, IGF2, IHH, MMP16
12MP:00053828.0COL2A1, IGF2, IHH, KLHDC2, MMP16, TGFB1
13MP:00036318.0CD36, COL2A1, IGF1, IGF2, IHH, NR3C1
14MP:00053767.5CD36, COL2A1, IGF1, IGF2, NR3C1, OSM
15MP:00053856.8CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
16MP:00053866.8CD36, COL2A1, IGF2, KLHDC2, MMP16, NR3C1
17MP:00107686.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
18MP:00053786.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2

Publications for Osteochondrosis

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Articles related to Osteochondrosis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
The development of locomotor kinetics in the foal and the effect of osteochondrosis. (27859501)
2016
2
Osteochondrosis dissecans of the temporomandibular joint: a case report and a review of literature. (27142101)
2016
3
Osteochondrosis of the capitellum of the humerus (Panner's disease, Osteochondritis Dissecans). Case study. (24728797)
2014
4
Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine. (23590509)
2013
5
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
6
Diagnostic sensitivity and interobserver agreement of radiography and ultrasonography for detecting trochlear ridge osteochondrosis lesions in the equine stifle. (23278908)
2013
7
Association of breeding conditions with prevalence of osteochondrosis in foals. (23118049)
2013
8
Genome-wide association studies for osteochondrosis in French Trotter horses. (21841084)
2012
9
Gene expression profiling from leukocytes of horses affected by osteochondrosis. (20108324)
2010
10
Sacral osteochondrosis in two German Shepherd Dogs. (19489784)
2009
11
Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs. (18564254)
2008
12
Use of 3D geometry modeling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells. (17552888)
2007
13
Early lesions of osteochondrosis in the distal tibia of foals. (17415757)
2007
14
Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosis. (14719712)
2004
15
Osteochondrosis of the superior pole of the patella: two cases with histologic correlation. (12180619)
2002
16
Millimeter waves in the treatment of neurological manifestations of vertebral osteochondrosis. (12434931)
2001
17
Equine dyschondroplasia (osteochondrosis)--histological findings and type VI collagen localization. (9265853)
1997
18
Osteochondrosis of the tarsal navicular in a female high school distance runner. (7738822)
1995
19
Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis. (8175922)
1994
20
Osteochondrosis associated with copper deficiency in young farmed red deer and wapiti x red deer hybrids. (16031764)
1994
21
Osteochondrosis of the tibial tuberosity (Osgood-Schlatter's disease) (2769094)
1989
22
Degeneration of cartilage canal vessels associated with lesions of osteochondrosis in swine. (2913703)
1989
23
Osteochondrosis of the temporomandibular joint presenting as an apparent parotid mass. (3605957)
1987
24
General and local [corrected] aetiologic factors in canine osteochondrosis. (3672862)
1987
25
Observation on the development of osteochondrosis in young rats. (3795864)
1986
26
Osteochondrosis of the tarsal cuneiforms. (3995827)
1985
27
Dyschondroplasias, including osteochondrosis, in boars between 25 and 169 days of age: radiologic changes. (6732024)
1984
28
Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses. (7056680)
1982
29
Degenerative joint disease with osteochondrosis of the proximal interphalangeal joint in young horses. (7096172)
1982
30
Osteochondrosis in feedlot cattle. (7257092)
1981
31
Age related changes and osteochondrosis in swine articular and epiphyseal cartilage: light ane electron microscopy. (7260732)
1981
32
Vertebral osteochondrosis (Scheuermann's kyphosis). (7273530)
1981
33
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
34
Osteochondrosis in six breeds of slaughter pigs. (22039856)
1980
35
Osteochondrosis in the horse. II. Pathology. (233595)
1978
36
Osteochondrosis in domestic animals. Introduction. (233603)
1978
37
Osteochondrosis in the horse. I. A clinical and radiologic investigation of osteochondritis dissecans of the knee and hock joint. (233593)
1978
38
Morphology of osteochondrosis and sequelae in pigs. (233602)
1978
39
Juvenile osteochondrosis. (271835)
1977
40
Osteochondrosis in the horse. (1110665)
1975
41
Osteochondrosis and arthrosis in pigs. VI. Relationship to feed level and calcium phosphorus and protein levels in the ration. (4853501)
1974
42
JUVENILE OSTEOCHONDROSIS OF THE HIP: CRITICAL EVALUATION OF PATHOGENESIS AND TREATMENT. (14290431)
1965
43
OSTEOCHONDROSIS OF THE CAPITULUM HUMERI (PANNER'S DISEASE). (14120485)
1964
44
Osteochondrosis deformans juvenilis dorsi. (13770264)
1961
45
Osteochondrosis of the capitulum humeri (Panners' disease); report of a case. (13606439)
1958
46
Observations on the differential diagnosis and sequelae of juvenile vertebral osteochondrosis. (13228191)
1954
47
Tibia vara; (osteochondrosis deformans tibiae); a survey of 23 cases. (14923172)
1952
48
Osteochondrosis dissecans in two brothers; the pre- and developed state. (14933225)
1952
49
Preventive and conservative treatment of osteochondrosis dissecans. (14894212)
1951
50
On treatment of osteochondrosis of the spine by spinal fusion. (18152750)
1949

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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GO Terms for genes affiliated with Osteochondrosis

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Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.2IGF1, IGF2, TGFB1
2extracellular spaceGO:00056157.6CD36, COL2A1, IGF1, IGF2, IHH, OSM

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycogen biosynthetic processGO:004572510.6IGF1, IGF2
2positive regulation of activated T cell proliferationGO:004210410.6IGF1, IGF2
3positive regulation of transcription regulatory region DNA bindingGO:200067910.6IGF1, TGFB1
4protein kinase B signalingGO:004349110.5IGF1, TGFB1
5cell activationGO:000177510.4IGF1, TGFB1
6response to fatty acidGO:007054210.3CD36, TBXAS1
7cell-cell junction organizationGO:004521610.2TGFB1, XIRP2
8female pregnancyGO:000756510.1IGF1, IGF2, TGFB1
9positive regulation of cell divisionGO:00517819.9IGF2, OSM, TGFB1
10endochondral ossificationGO:00019589.9COL2A1, MMP16
11platelet degranulationGO:00025769.9CD36, IGF1, IGF2, TGFB1
12positive regulation of mitotic nuclear divisionGO:00458409.9IGF1, IGF2
13positive regulation of epithelial cell proliferationGO:00506799.8IGF1, IHH, TGFB1
14regulation of gene expressionGO:00104689.6COL2A1, IGF1, TGFB1
15response to estradiolGO:00323559.6IGF2, IHH, TGFB1
16positive regulation of cell migrationGO:00303359.6IGF1, SEMA3D, TGFB1
17skeletal system developmentGO:00015019.5COL2A1, IGF1, IGF2, IHH
18positive regulation of MAPK cascadeGO:00434109.4CD36, IGF1, IGF2, OSM
19positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2CD36, IGF1, IGF2, OSM, TGFB1
20positive regulation of cell proliferationGO:00082848.8IGF1, IGF2, OSM, TGFB1
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.6IGF1, IHH, NR3C1, OSM, TGFB1

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.4IGF1, IGF2
2protein serine/threonine kinase activator activityGO:004353910.2IGF2, TGFB1
3steroid bindingGO:000549610.1IGF1, NR3C1
4insulin receptor bindingGO:000515810.0IGF1, IGF2
5growth factor activityGO:00080839.3IGF1, IGF2, OSM, TGFB1

Sources for Osteochondrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet