MCID: OST016
MIFTS: 50

Osteochondrosis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteochondrosis

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Aliases & Descriptions for Osteochondrosis:

Name: Osteochondrosis 35 11 48 13 68
Osteochondritis Juvenilis 11 68
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 11
 
Juvenile Osteochondrosis of Tibial Tubercle 68
Epiphyseal Necrosis, Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:8125
ICD1030 M92, M93.9
ICD9CM32 732.6
MeSH39 D055034
NCIt45 C34879

Summaries for Osteochondrosis

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Disease Ontology:11 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary: Osteochondrosis, also known as osteochondritis juvenilis, is related to legg-calve-perthes disease and kohler's disease, and has symptoms including arthralgia and joint swelling. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and EGFR Transactivation by Gastrin. Affiliated tissues include bone, bone and bone marrow, and related mouse phenotypes are Decreased viability with paclitaxel and Increased shRNA abundance (Z-score > 2).

Wikipedia:71 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1legg-calve-perthes disease11.9
2kohler's disease11.7
3scheuermann disease11.7
4panner disease11.7
5blount's disease11.6
6osgood-schlatter's disease11.4
7kienbock's disease11.1
8sinding-larsen-johansson disease11.1
9freiberg's disease10.9
10thiemann disease10.7
11necrotizing ulcerative gingivitis10.5IGF1, IGF2
12hallux varus and preaxial polysyndactyly10.5IGF1, IGF2
13congenital methemoglobinemia10.5CD36, TGFB1
14growth hormone insensitivity, partial10.5IGF1, IGF2
15keratopathy10.5CD36, TGFB1
16fibrosclerosis of breast10.4IGF1, TGFB1
17fibromatosis, gingival, 110.4CD36, TGFB1
18fetal methyl mercury syndrome10.4IGF1, IGF2
19kartagener syndrome10.4IGF1, IGF2
20splenic artery aneurysm10.3IGF1, IGF2
21multiple mitochondrial dysfunctions syndrome10.3CD36, IGF1, IGF2
22pyoderma gangrenosum10.3IGF1, NR3C1, TGFB1
23perivascular epithelioid cell tumor10.3IGF1, IGF2
24bone marrow cancer10.3IGF1, IGF2
25lissencephaly, x-linked 210.3COL2A1, IGF1
26small cell cancer of the lung, somatic10.2IGF1, IGF2, TGFB1
27cutaneous leiomyosarcoma10.2IGF2, IHH
28malignant dermis tumor10.2IGF2, IHH
29smed strudwick type10.2CD36, COL2A1
30osteochondritis dissecans10.2
31leukemia10.1IGF1, TGFB1
32papillary extrahepatic bile duct adenocarcinoma10.1COL2A1, TBXAS1
33cervicitis10.1
34chylomicron retention disease10.0CD36, IGF1, NR3C1, TGFB1
35osteoarthritis10.0
36xanthomatosis9.9COL2A1, TBXAS1, TGFB1
37sacral agenesis with vertebral anomalies9.9
38upington disease9.9
39insulin-like growth factor i9.8
40spondylosis9.8
41osteoporosis9.7
42spinal stenosis9.7
43scoliosis9.7
44osteomyelitis9.7
45nephrocalcinosis9.7
46ischemia9.7
47chronic pain9.7
48toenail dystrophy, isolated9.5COL2A1, IHH
49bone resorption disease9.4COL2A1, KLHDC2, SEMA3D, TBXAS1
50osteopetrosis6.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms & Phenotypes for Osteochondrosis

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UMLS symptoms related to Osteochondrosis:


arthralgia, joint swelling

GenomeRNAi Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A9.9IGF1, TGFB1
2GR00366-A-359.2CD36, NR3C1, SEMA3D

MGI Mouse Phenotypes related to Osteochondrosis according to GeneCards Suite gene sharing:

41 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2CD36, COL2A1, IGF1, NR3C1, TGFB1
2MP:00053889.0COL2A1, IGF1, IGF2, IHH, NR3C1, TGFB1
3MP:00053719.0COL2A1, IGF1, IGF2, IHH, MMP16
4MP:00053678.9CD36, COL2A1, IGF1, IGF2, NR3C1, TGFB1
5MP:00053708.9CD36, COL2A1, IGF2, NR3C1, TGFB1, XIRP2
6MP:00107718.7IGF1, IGF2, NR3C1, OSM, TGFB1, XIRP2
7MP:00053698.5CD36, IGF1, IGF2, IHH, NR3C1, TGFB1
8MP:00053918.3CD36, COL2A1, IGF2, IHH, KLHDC2, TGFB1
9MP:00053878.1CD36, COL2A1, IGF1, IGF2, NR3C1, OSM
10MP:00053818.1CD36, COL2A1, IGF2, IHH, MMP16, NR3C1
11MP:00053908.0CD36, COL2A1, IGF1, IGF2, IHH, MMP16
12MP:00053828.0COL2A1, IGF2, IHH, KLHDC2, MMP16, TGFB1
13MP:00036318.0CD36, COL2A1, IGF1, IGF2, IHH, NR3C1
14MP:00053767.5CD36, COL2A1, IGF1, IGF2, NR3C1, OSM
15MP:00053856.8CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
16MP:00053866.8CD36, COL2A1, IGF2, KLHDC2, MMP16, NR3C1
17MP:00107686.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
18MP:00053786.6CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2

Drugs & Therapeutics for Osteochondrosis

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Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AnestheticsPhase 2, Phase 3, Phase 19001
2Fibrin Tissue AdhesivePhase 2, Phase 3145
3
Lidocaineapproved, vet_approvedPhase 1, Phase 21226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
4Sodium Channel BlockersPhase 1, Phase 21515
5Peripheral Nervous System AgentsPhase 1, Phase 222776
6Diuretics, Potassium SparingPhase 1, Phase 21827
7Central Nervous System DepressantsPhase 1, Phase 212806
8Anesthetics, LocalPhase 1, Phase 23272
9Anti-Arrhythmia AgentsPhase 1, Phase 22969
10Calcium, Dietary5525
11AstragalusNutraceutical52

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral DefectsRecruitingNCT02423629Phase 4
2The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage DefectsUnknown statusNCT00891501Phase 2, Phase 3
3Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized TrialCompletedNCT00560664Phase 3
4Treatment of the Osgood SchlatterRecruitingNCT02824172Phase 3
5Effectiveness of Dextrose Injection for Osgood-Schlatter DiseaseCompletedNCT01300754Phase 1, Phase 2
6Comparison of Standard Fusion With "Topping Off"-System in Lumbar SpineUnknown statusNCT01224379
7Osteochondritis Dissecans of the KneeUnknown statusNCT01455987
8Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionUnknown statusNCT02289976
9Prospective Study of Scheuermann's KyphosisCompletedNCT00738309
10Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
11Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
12Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease.Not yet recruitingNCT02799394
13Cytokine Profiles in SpondylodiscitisNot yet recruitingNCT02554227
14A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral DefectsTerminatedNCT01209390
15Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the KneeWithdrawnNCT02308358
16Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave TherapyWithdrawnNCT01631409

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel, PMIDs: 17515233, 17590152, 16510814

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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MalaCards organs/tissues related to Osteochondrosis:

36
Bone, Bone marrow, Testes

FMA organs/tissues related to Osteochondrosis:

17
Bone

Publications for Osteochondrosis

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Articles related to Osteochondrosis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
The development of locomotor kinetics in the foal and the effect of osteochondrosis. (27859501)
2016
2
Osteochondrosis dissecans of the temporomandibular joint: a case report and a review of literature. (27142101)
2016
3
Candidate gene analysis of osteochondrosis in Spanish Purebred horses. (27422688)
2016
4
Impact of feeding and housing on the development of osteochondrosis in foals-A longitudinal study. (27094134)
2016
5
Identification and validation of risk loci for osteochondrosis in standardbreds. (26753841)
2016
6
Prevalence and characteristics of osteochondrosis in 309 Spanish Purebred horses. (26670332)
2016
7
Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses. (27448988)
2016
8
Direct comparison of different surgical approaches in a woman with bilateral osteochondrosis dissecans of her knees: a case report. (26786243)
2016
9
OSTEOCHONDROSIS IN THE DISTAL FEMURS OF AN ADULT RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS RETICULATA): MACROSCOPIC, RADIOLOGIC, AND HISTOLOGIC FINDINGS. (27010303)
2016
10
In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. (27283998)
2016
11
Vitamin D Deficiency: The Missing Etiological Factor in the Development of Juvenile Osteochondrosis Dissecans? (28009798)
2016
12
Preliminary report on osteochondrosis in cattle in the north-western parts of South Africa. (27543146)
2016
13
Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: Quantitative MRI, second-harmonic microscopy, and histological findings. (27734566)
2016
14
Prevalence of humeral head osteochondrosis in the Greater Swiss Mountain dog and the Border Collie in Switzerland. (27821378)
2016
15
Osteochondrosis prevalence and severity at 12 and 24 weeks of age in commercial pigs with and without organic-complexed trace mineral supplementation. (27898885)
2016
16
Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis-susceptible sites in foals revealed by SWI 3T MRI. (26740060)
2016
17
Wnt/ I^-catenin signaling of cartilage canal and osteochondral junction chondrocytes and full thickness cartilage in early equine osteochondrosis. (25676127)
2015
18
Bilateral osteochondrosis of the distal tibial epiphysis: a case report. (25504104)
2015
19
Osteochondrosis of the accessory ossification centre of the medial malleolus. (25438106)
2015
20
Age-dependent expression of osteochondrosis-related genes in equine leukocytes. (26392886)
2015
21
Osteochondrosis, but not lameness, is more frequent among free-range pigs than confined herd-mates. (26416598)
2015
22
Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model. (26473611)
2015
23
An Update on the Pathogenesis of Osteochondrosis. (26080832)
2015
24
Dissolution of the capitellum after nondisplaced supracondylar fracture of the humerus in a child: a case report of transient osteochondrosis. (25647568)
2015
25
Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis. (25463443)
2015
26
Identification of novel osteochondrosis- associated genes. (26296056)
2015
27
Associations of conformation and locomotive characteristics in growing gilts with osteochondrosis at slaughter. (25568360)
2015
28
Osteochondrosis of the capitellum of the humerus (Panner's disease, Osteochondritis Dissecans). Case study. (24728797)
2014
29
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses. (25428408)
2014
30
Osteochondrosis of the inferior pole of the scapula (Roca disease). (23838852)
2014
31
The influence of floor type before and after 10 weeks of age on osteochondrosis in growing gilts. (24987085)
2014
32
Short- and long-term racing performance of Standardbred pacers and trotters after early surgical intervention for tarsal osteochondrosis. (24819047)
2014
33
Genetic trends of conformation traits and genetic correlations to osteochondrosis in boars. (24816139)
2014
34
DIAGNOSTIC SENSITIVITY OF RADIOGRAPHY, ULTRASONOGRAPHY, AND MAGNETIC RESONANCE IMAGING FOR DETECTING SHOULDER OSTEOCHONDROSIS/OSTEOCHONDRITIS DISSECANS IN DOGS. (24844132)
2014
35
Omics technologies provide new insights into the molecular physiopathology of equine osteochondrosis. (25359417)
2014
36
Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. (25227120)
2014
37
Arthroscopic assessment of osteochondrosis of the medial humeral condyle treated with debridement and sliding humeral osteotomy. (25109907)
2014
38
Treatment of Osteochondrosis Dissecans in the Stifle and Tarsus of Juvenile Thoroughbred Horses. (25243728)
2014
39
Ossification defects detected in CT scans represent early osteochondrosis in the distal femur of piglets. (24740876)
2014
40
Consequences of the natural course of articular osteochondrosis in pigs for the suitability of computed tomography as a screening tool. (25199991)
2014
41
Bilateral osteochondrosis of the primary patellar ossification centers in a young athlete: a case report. (23797161)
2014
42
Heritability estimates of tarsocrural osteochondrosis and palmar/plantar first phalanx osteochondral fragments in Standardbred trotters. (23448227)
2014
43
Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine. (23590509)
2013
44
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
45
Diagnostic sensitivity and interobserver agreement of radiography and ultrasonography for detecting trochlear ridge osteochondrosis lesions in the equine stifle. (23278908)
2013
46
Association of breeding conditions with prevalence of osteochondrosis in foals. (23118049)
2013
47
Osteochondrosis in foals. (23625248)
2013
48
Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans. (23428601)
2013
49
Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. (23278111)
2013
50
Comparison of clinical and computed tomographic features between medial and lateral trochlear ridge talar osteochondrosis in dogs. (23241002)
2013

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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GO Terms for genes affiliated with Osteochondrosis

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Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6IGF1, IGF2, TGFB1
2extracellular spaceGO:00056158.1CD36, COL2A1, IGF1, IGF2, IHH, OSM

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:004210410.7IGF1, IGF2
2positive regulation of glycogen biosynthetic processGO:004572510.7IGF1, IGF2
3positive regulation of mitotic nuclear divisionGO:004584010.7IGF1, IGF2
4cell activationGO:000177510.7IGF1, TGFB1
5positive regulation of transcription regulatory region DNA bindingGO:200067910.6IGF1, TGFB1
6protein kinase B signalingGO:004349110.5IGF1, TGFB1
7cell-cell junction organizationGO:004521610.4TGFB1, XIRP2
8female pregnancyGO:000756510.4IGF1, IGF2, TGFB1
9response to fatty acidGO:007054210.3CD36, TBXAS1
10positive regulation of cell migrationGO:003033510.3IGF1, SEMA3D, TGFB1
11endochondral ossificationGO:000195810.2COL2A1, MMP16
12positive regulation of epithelial cell proliferationGO:005067910.2IGF1, IHH, TGFB1
13regulation of gene expressionGO:001046810.1COL2A1, IGF1, TGFB1
14positive regulation of cell divisionGO:005178110.1IGF2, OSM, TGFB1
15platelet degranulationGO:000257610.1CD36, IGF1, IGF2, TGFB1
16response to estradiolGO:003235510.0IGF2, IHH, TGFB1
17positive regulation of MAPK cascadeGO:00434109.9CD36, IGF1, IGF2, OSM
18positive regulation of cell proliferationGO:00082849.8IGF1, IGF2, OSM, TGFB1
19positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5CD36, IGF1, IGF2, OSM, TGFB1
20positive regulation of transcription from RNA polymerase II promoterGO:00459449.3IGF1, IHH, NR3C1, OSM, TGFB1
21skeletal system developmentGO:00015019.1COL2A1, IGF1, IGF2, IHH

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:000515810.4IGF1, IGF2
2insulin-like growth factor receptor bindingGO:000515910.4IGF1, IGF2
3protein serine/threonine kinase activator activityGO:004353910.3IGF2, TGFB1
4steroid bindingGO:00054969.9IGF1, NR3C1
5growth factor activityGO:00080839.6IGF1, IGF2, OSM, TGFB1

Sources for Osteochondrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet