Aliases & Classifications for Osteochondrosis

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Aliases & Descriptions for Osteochondrosis:

Name: Osteochondrosis 33 11 13 66
Osteochondritis Juvenilis 11 66
Osteochondrosis Not Specified As Adult or Juvenile, of Unspecified Site 11
 
Juvenile Osteochondrosis of Tibial Tubercle 66
Epiphyseal Necrosis, Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:8125
ICD1028 M92, M93.9
ICD9CM30 732.6
MeSH37 D055034
NCIt43 C34879

Summaries for Osteochondrosis

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Disease Ontology:11 An ischemic bone disease that results in necrosis followed by regrowth in children and teens located in bone.

MalaCards based summary: Osteochondrosis, also known as osteochondritis juvenilis, is related to legg-calve-perthes disease and blount's disease, and has symptoms including arthralgia and joint swelling. An important gene associated with Osteochondrosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways are EGFR Transactivation by Gastrin and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include bone, bone and bone marrow, and related mouse phenotypes are adipose tissue and liver/biliary system.

Wikipedia:69 Osteochondrosis is a family of orthopedic diseases of the joint that occur in children and adolescents... more...

Related Diseases for Osteochondrosis

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Diseases related to Osteochondrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1legg-calve-perthes disease11.8
2blount's disease11.7
3kohler's disease11.7
4scheuermann disease11.7
5osgood-schlatter's disease11.5
6panner disease11.4
7kienbock's disease11.2
8sinding-larsen-johansson disease11.2
9freiberg's disease11.0
10thiemann disease10.8
11necrotizing ulcerative gingivitis10.6IGF1, IGF2
12hallux varus and preaxial polysyndactyly10.6IGF1, IGF2
13growth hormone insensitivity, partial10.6IGF1, IGF2
14fetal methyl mercury syndrome10.6IGF1, IGF2
15fibrosclerosis of breast10.5IGF1, TGFB1
16congenital methemoglobinemia10.5CD36, TGFB1
17keratopathy10.5CD36, TGFB1
18kartagener syndrome10.5IGF1, IGF2
19cutaneous leiomyosarcoma10.5IGF2, IHH
20fibromatosis, gingival, 110.5CD36, TGFB1
21malignant dermis tumor10.5IGF2, IHH
22lissencephaly, x-linked 210.4COL2A1, IGF1
23splenic artery aneurysm10.4IGF1, IGF2
24intracranial arteriovenous malformation10.4CD36, TGFB1
25perivascular epithelioid cell tumor10.4IGF1, IGF2
26multiple mitochondrial dysfunctions syndrome10.4CD36, IGF1, IGF2
27pyoderma gangrenosum10.3IGF1, NR3C1, TGFB1
28bone marrow cancer10.3IGF1, IGF2
29small cell cancer of the lung, somatic10.3IGF1, IGF2, TGFB1
30osteochondritis dissecans10.3
31cervicitis10.2
32leukemia10.1IGF1, TGFB1
33papillary extrahepatic bile duct adenocarcinoma10.1COL2A1, TBXAS1
34osteoarthritis10.1
35sacral agenesis with vertebral anomalies10.0
36upington disease10.0
37chylomicron retention disease10.0CD36, IGF1, NR3C1, TGFB1
38leber congenital amaurosis 310.0ACAN, COL2A1
39insulin-like growth factor i9.9
40spondylosis9.9
41pauciarticular onset juvenile idiopathic arthritis9.9ACAN, CD36
42osteoporosis9.8
43spinal stenosis9.8
44scoliosis9.8
45osteomyelitis9.8
46nephrocalcinosis9.8
47ischemia9.8
48chronic pain9.8
49acromesomelic dysplasia9.8ACAN, COL2A1
50toenail dystrophy, isolated9.7COL2A1, IHH

Graphical network of the top 20 diseases related to Osteochondrosis:



Diseases related to osteochondrosis

Symptoms for Osteochondrosis

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UMLS symptoms related to Osteochondrosis:


arthralgia, joint swelling

Drugs & Therapeutics for Osteochondrosis

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Drugs for Osteochondrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LidocainePhase 1, Phase 21168137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral DefectsRecruitingNCT02423629Phase 4
2Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized TrialCompletedNCT00560664Phase 3
3Treatment of the Osgood SchlatterRecruitingNCT02824172Phase 3
4The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage DefectsRecruitingNCT00891501Phase 2, Phase 3
5Effectiveness of Dextrose Injection for Osgood-Schlatter DiseaseCompletedNCT01300754Phase 1, Phase 2
6Prospective Study of Scheuermann's KyphosisCompletedNCT00738309
7Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the KneeRecruitingNCT01754298
8Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee:RecruitingNCT02397278
9Talar Avascular Necrosis: Surgical Angiogenesis vs. Core DecompressionRecruitingNCT02289976
10Osteochondritis Dissecans of the KneeEnrolling by invitationNCT01455987
11Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease.Not yet recruitingNCT02799394
12Comparison of Standard Fusion With "Topping Off"-System in Lumbar SpineNot yet recruitingNCT01224379
13Cytokine Profiles in SpondylodiscitisNot yet recruitingNCT02554227
14A Prospective, Post-marketing Registry on the Use of ChondroMimetic for the Repair of Osteochondral DefectsTerminatedNCT01209390
15Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave TherapyWithdrawnNCT01631409
16Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the KneeWithdrawnNCT02308358

Search NIH Clinical Center for Osteochondrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Osteochondrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteochondrosis:
Carticel
Embryonic/Adult Cultured Cells Related to Osteochondrosis:
Chondrocytes (Carticel, PMIDs: 17515233, 17590152, 16510814

Genetic Tests for Osteochondrosis

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Anatomical Context for Osteochondrosis

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MalaCards organs/tissues related to Osteochondrosis:

34
Bone, Bone marrow, Testes

FMA organs/tissues related to Osteochondrosis:

17
Bone

Animal Models for Osteochondrosis or affiliated genes

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MGI Mouse Phenotypes related to Osteochondrosis:

39 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.3CD36, COL2A1, IGF1, NR3C1, TGFB1
2MP:00053709.0CD36, COL2A1, IGF2, NR3C1, TGFB1, XIRP2
3MP:00053889.0COL2A1, IGF1, IGF2, IHH, NR3C1, TGFB1
4MP:00053678.9CD36, COL2A1, IGF1, IGF2, NR3C1, TGFB1
5MP:00053698.6CD36, IGF1, IGF2, IHH, NR3C1, TGFB1
6MP:00053918.5CD36, COL2A1, IGF2, IHH, KLHDC2, TGFB1
7MP:00053718.5COL2A1, IGF1, IGF2, IHH, MMP16
8MP:00053828.3COL2A1, IGF2, IHH, KLHDC2, MMP16, TGFB1
9MP:00053818.1CD36, COL2A1, IGF2, IHH, MMP16, NR3C1
10MP:00053907.6CD36, COL2A1, IGF1, IGF2, IHH, MMP16
11MP:00053867.3CD36, COL2A1, IGF2, KLHDC2, MMP16, NR3C1
12MP:00053857.2CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
13MP:00107686.8CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2
14MP:00053786.7CD36, COL2A1, IGF1, IGF2, IHH, KLHDC2

Publications for Osteochondrosis

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Articles related to Osteochondrosis:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Osteochondrosis dissecans of the temporomandibular joint: a case report and a review of literature. (27142101)
2016
2
Osteochondrosis of the capitellum of the humerus (Panner's disease, Osteochondritis Dissecans). Case study. (24728797)
2014
3
Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine. (23590509)
2013
4
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses. A retrospective study of 37 horses. (23238225)
2013
5
Diagnostic sensitivity and interobserver agreement of radiography and ultrasonography for detecting trochlear ridge osteochondrosis lesions in the equine stifle. (23278908)
2013
6
Association of breeding conditions with prevalence of osteochondrosis in foals. (23118049)
2013
7
Genome-wide association studies for osteochondrosis in French Trotter horses. (21841084)
2012
8
Gene expression profiling from leukocytes of horses affected by osteochondrosis. (20108324)
2010
9
Genetic parameters for bone strength, osteochondrosis and meat percentage in Finnish Landrace and Yorkshire pigs. (22444651)
2010
10
Sacral osteochondrosis in two German Shepherd Dogs. (19489784)
2009
11
Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs. (18564254)
2008
12
Use of 3D geometry modeling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells. (17552888)
2007
13
Early lesions of osteochondrosis in the distal tibia of foals. (17415757)
2007
14
Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosis. (14719712)
2004
15
Osteochondrosis of the superior pole of the patella: two cases with histologic correlation. (12180619)
2002
16
Millimeter waves in the treatment of neurological manifestations of vertebral osteochondrosis. (12434931)
2001
17
Equine dyschondroplasia (osteochondrosis)--histological findings and type VI collagen localization. (9265853)
1997
18
Osteochondrosis of the tarsal navicular in a female high school distance runner. (7738822)
1995
19
Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis. (8175922)
1994
20
Osteochondrosis associated with copper deficiency in young farmed red deer and wapiti x red deer hybrids. (16031764)
1994
21
Osteochondrosis of the tibial tuberosity (Osgood-Schlatter's disease) (2769094)
1989
22
Degeneration of cartilage canal vessels associated with lesions of osteochondrosis in swine. (2913703)
1989
23
Osteochondrosis of the temporomandibular joint presenting as an apparent parotid mass. (3605957)
1987
24
General and local [corrected] aetiologic factors in canine osteochondrosis. (3672862)
1987
25
Observation on the development of osteochondrosis in young rats. (3795864)
1986
26
Osteochondrosis of the tarsal cuneiforms. (3995827)
1985
27
Dyschondroplasias, including osteochondrosis, in boars between 25 and 169 days of age: radiologic changes. (6732024)
1984
28
Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses. (7056680)
1982
29
Degenerative joint disease with osteochondrosis of the proximal interphalangeal joint in young horses. (7096172)
1982
30
Osteochondrosis in feedlot cattle. (7257092)
1981
31
Age related changes and osteochondrosis in swine articular and epiphyseal cartilage: light ane electron microscopy. (7260732)
1981
32
Vertebral osteochondrosis (Scheuermann's kyphosis). (7273530)
1981
33
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
34
Osteochondrosis in six breeds of slaughter pigs. (22039856)
1980
35
Osteochondrosis in the horse. II. Pathology. (233595)
1978
36
Osteochondrosis in domestic animals. Introduction. (233603)
1978
37
Osteochondrosis in the horse. I. A clinical and radiologic investigation of osteochondritis dissecans of the knee and hock joint. (233593)
1978
38
Morphology of osteochondrosis and sequelae in pigs. (233602)
1978
39
Juvenile osteochondrosis. (271835)
1977
40
Osteochondrosis in the horse. (1110665)
1975
41
Osteochondrosis and arthrosis in pigs. VI. Relationship to feed level and calcium phosphorus and protein levels in the ration. (4853501)
1974
42
JUVENILE OSTEOCHONDROSIS OF THE HIP: CRITICAL EVALUATION OF PATHOGENESIS AND TREATMENT. (14290431)
1965
43
OSTEOCHONDROSIS OF THE CAPITULUM HUMERI (PANNER'S DISEASE). (14120485)
1964
44
Osteochondrosis deformans juvenilis dorsi. (13770264)
1961
45
Osteochondrosis of the capitulum humeri (Panners' disease); report of a case. (13606439)
1958
46
Observations on the differential diagnosis and sequelae of juvenile vertebral osteochondrosis. (13228191)
1954
47
Tibia vara; (osteochondrosis deformans tibiae); a survey of 23 cases. (14923172)
1952
48
Osteochondrosis dissecans in two brothers; the pre- and developed state. (14933225)
1952
49
Preventive and conservative treatment of osteochondrosis dissecans. (14894212)
1951
50
On treatment of osteochondrosis of the spine by spinal fusion. (18152750)
1949

Variations for Osteochondrosis

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Expression for genes affiliated with Osteochondrosis

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Search GEO for disease gene expression data for Osteochondrosis.

Pathways for genes affiliated with Osteochondrosis

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GO Terms for genes affiliated with Osteochondrosis

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Cellular components related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.2IGF1, IGF2, TGFB1
2Golgi lumenGO:00057969.0ACAN, MMP16, TGFB1
3proteinaceous extracellular matrixGO:00055788.3ACAN, COL2A1, MMP16, TGFB1
4extracellular spaceGO:00056158.2CD36, COL2A1, IGF1, IGF2, IHH, SEMA3D

Biological processes related to Osteochondrosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycogen biosynthetic processGO:004572510.5IGF1, IGF2
2positive regulation of transcription regulatory region DNA bindingGO:200067910.5IGF1, TGFB1
3positive regulation of activated T cell proliferationGO:004210410.5IGF1, IGF2
4protein kinase B signalingGO:004349110.4IGF1, TGFB1
5cell activationGO:000177510.4IGF1, TGFB1
6cell-cell junction organizationGO:004521610.1TGFB1, XIRP2
7response to fatty acidGO:007054210.1CD36, TBXAS1
8proteoglycan biosynthetic processGO:003016610.0ACAN, IGF1
9positive regulation of mitotic nuclear divisionGO:004584010.0IGF1, IGF2
10positive regulation of MAPK cascadeGO:00434109.9CD36, IGF1, IGF2
11female pregnancyGO:00075659.9IGF1, IGF2, TGFB1
12platelet degranulationGO:00025769.8CD36, IGF1, IGF2, TGFB1
13positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7CD36, IGF1, IGF2, TGFB1
14positive regulation of epithelial cell proliferationGO:00506799.7IGF1, IHH, TGFB1
15regulation of gene expressionGO:00104689.6COL2A1, IGF1, TGFB1
16endochondral ossificationGO:00019589.5COL2A1, MMP16
17positive regulation of cell migrationGO:00303359.5IGF1, SEMA3D, TGFB1
18response to estradiolGO:00323559.2IGF2, IHH, TGFB1
19skeletal system developmentGO:00015018.8ACAN, COL2A1, IGF1, IGF2, IHH

Molecular functions related to Osteochondrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.4IGF1, IGF2
2protein serine/threonine kinase activator activityGO:004353910.2IGF2, TGFB1
3steroid bindingGO:000549610.1IGF1, NR3C1
4insulin receptor bindingGO:000515810.0IGF1, IGF2
5growth factor activityGO:00080839.8IGF1, IGF2, TGFB1

Sources for Osteochondrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet