MCID: OST032
MIFTS: 37

Osteofibrous Dysplasia malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteofibrous Dysplasia

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Aliases & Descriptions for Osteofibrous Dysplasia:

Name: Osteofibrous Dysplasia 45 47 65
Jaffe-Campanacci Syndrome 45 65
 
Ossifying Fibroma 45 65
Intracortical Fibrous Dysplasia 45

Classifications:



External Ids:

UMLS65 C1709353, C0796000

Summaries for Osteofibrous Dysplasia

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Wikipedia:68 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

MalaCards based summary: Osteofibrous Dysplasia, also known as jaffe-campanacci syndrome, is related to fibromatosis multiple non ossifying and chest wall lymphoma. An important gene associated with Osteofibrous Dysplasia is SPARC (Secreted Protein Acidic And Cysteine Rich), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and FGF signaling pathway. Affiliated tissues include bone, liver and breast, and related mouse phenotypes are muscle and cardiovascular system.

Related Diseases for Osteofibrous Dysplasia

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Diseases related to Osteofibrous Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis multiple non ossifying11.5
2chest wall lymphoma10.6NF1, SPARC
3chief cell adenoma10.5BGLAP, SPARC
4osteogenesis imperfecta, type iii10.5CD36, SPARC
5prion disease10.5BGLAP, SPARC
6diencephalic astrocytomas10.5GNAS, NF1
7caffey disease10.4BGLAP, CD36
8gray platelet syndrome10.4CD36, SPARC
9uterine benign neoplasm10.4GNAS, SPARC
10heavy chain disease10.4GNAS, SPARC
11osteogenesis imperfecta, type ii10.4BGLAP, CD36
12marcus gunn phenomenon10.3BGLAP, CD36
13fibroma10.3
14ossifying fibroma10.3
15bone inflammation disease10.3BGLAP, GNAS
16neurofibromatosis, type 110.3
17neurofibromatosis10.3
18bone osteosarcoma10.3GNAS, SPARC
19cutaneous ganglioneuroma10.3SPP1, VIM
20epileptic encephalopathy, early infantile, 2610.3BGLAP, GNAS
21odontoma10.2CD36, VIM
22fibrous dysplasia10.2
23breast adenomyoepithelial adenosis10.2NF1, VIM
24rectosigmoid junction neoplasm10.2BGLAP, SPARC, SPP1
25small cell cancer of the lung, somatic10.1BGLAP, SPARC, SPP1
26articulation disorder10.1BGLAP, GNAS
27cellular schwannoma10.1NF1, VIM
28pseudoarthrosis10.1
29perineurioma10.1MUC1, NF1
30adrenal carcinoma10.0BGLAP, GNAS
31angiokeratoma of mibelli10.0NF1, VIM
32vein disease10.0CD36, MUC1
33pseudopseudohypoparathyroidism10.0BGLAP, GNAS, SPARC
34craniodiaphyseal dysplasia10.0BGLAP, GNAS, SPARC
35familial abdominal aortic aneurysm10.0BGLAP, CD36
36vulvar clear cell hidradenocarcinoma10.0KRT1, MUC1
37costello syndrome9.9
38aneurysmal bone cysts9.9
39sarcoma9.9
40long bone adamantinoma9.9
41aneurysm9.9
42large cell neuroendocrine carcinoma9.9GNAS, VIM
43pancreatic foamy gland adenocarcinoma9.9GNAS, MUC1
44eosinophilic pneumonia9.9BGLAP, SPARC, VIM
45papillary adenocarcinoma9.9MUC1, SPP1
46malignant ovarian brenner tumor9.9MUC1, VIM
47absence of fingerprints congenital milia9.9MUC1, VIM
48anovulation9.9MUC1, VIM
49malignant teratocarcinosarcoma9.9MUC1, VIM
50rectum mucinous adenocarcinoma9.9MUC1, VIM

Graphical network of the top 20 diseases related to Osteofibrous Dysplasia:



Diseases related to osteofibrous dysplasia

Symptoms for Osteofibrous Dysplasia

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Drugs & Therapeutics for Osteofibrous Dysplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Osteofibrous Dysplasia

Genetic Tests for Osteofibrous Dysplasia

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Anatomical Context for Osteofibrous Dysplasia

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MalaCards organs/tissues related to Osteofibrous Dysplasia:

33
Bone, Liver, Breast, Lung, Endothelial, Tongue, Temporal lobe

Animal Models for Osteofibrous Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Osteofibrous Dysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1CD36, GNAS, NF1, SPP1, VIM
2MP:00053857.2CD36, GNAS, KRT1, NF1, SPP1, VIM
3MP:00053767.2CD36, GNAS, KRT1, NF1, SPARC, SPP1
4MP:00053787.1CD36, GNAS, KRT1, NF1, SPARC, SPP1
5MP:00053977.0CD36, GNAS, KRT1, NF1, SPARC, SPP1
6MP:00053876.7CD36, GNAS, KRT1, NF1, SPARC, SPP1

Publications for Osteofibrous Dysplasia

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Articles related to Osteofibrous Dysplasia:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Autologous mesenchymal stem cell (MSCs) transplantation for critical-sized bone defect following a wide excision of osteofibrous dysplasia. (26599503)
2015
2
Osteofibrous Dysplasia-like Adamantinoma of the Tibia in a 15-Year-Old Girl. (26447423)
2015
3
Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. (26637977)
2015
4
Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. (24199850)
2014
5
Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones. (21983933)
2012
6
Neonatal osteofibrous dysplasia associated with pathological tibia fracture: a case report and review of the literature. (21383639)
2012
7
Marginal excision and Ilizarov hemicallotasis for osteofibrous dysplasia of the tibia: a case report. (21164362)
2011
8
Osteofibrous dysplasia and adamantinoma. (20511441)
2010
9
Minimally invasive plate osteosynthesis for osteofibrous dysplasia of the tibia: a case report. (21187556)
2010
10
Congenital osteofibrous dysplasia of the tibia, associated with pseudoarthrosis of the ipsilateral fibula. (18946584)
2008
11
Treatment of osteofibrous dysplasia and associated lesions. (17594160)
2007
12
Frequent immunoexpression of TGF-beta1, FGF-2 and BMP-2 in fibroblast-like cells in osteofibrous dysplasia. (17273729)
2007
13
A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature. (16636523)
2006
14
Familial osteofibrous dysplasia. A case series. (16203897)
2005
15
Osteofibrous dysplasia and adamantinoma: correlation of proto-oncogene product and matrix protein expression. (14745727)
2004
16
Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. (15258702)
2004
17
Osteofibrous dysplasia treated with distraction osteogenesis: a report of two cases. (15449128)
2004
18
Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst. (12574919)
2003
19
Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. (12679847)
2003
20
Comparative study of fibrous dysplasia and osteofibrous dysplasia: histopathological, immunohistochemical, argyrophilic nucleolar organizer region and DNA ploidy analysis. (11564214)
2001
21
Immunoexpression of neurofibromin, S-100 protein, and leu-7 and mutation analysis of the NF1 gene at codon 1423 in osteofibrous dysplasia. (11727265)
2001
22
Osteofibrous dysplasia of the ulna. (11793188)
2001
23
Osteofibrous dysplasia of the ulna. (11764436)
2001
24
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. (11272890)
2000
25
Osteofibrous dysplasia of the tibia: case report and review of the literature. (10709600)
1999
26
Treatment outcome of osteofibrous dysplasia. (9702669)
1998
27
Osteofibrous dysplasia-like adamantinoma of bone: a report of five cases with immunohistochemical and ultrastructural studies. (9712421)
1998
28
Cytogenetic analysis of adamantinoma of long bones: further indications for a common histogenesis with osteofibrous dysplasia. (9242211)
1997
29
Neonatal osteofibrous dysplasia: report of two cases. (8677152)
1996
30
Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias. (7635871)
1995
31
Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinoma. (8156503)
1994
32
Relationship between osteofibrous dysplasia and adamantinoma. (7994967)
1994
33
Aggressive bone tumorous lesion in infancy: osteofibrous dysplasia of the tibia and fibula. (8376555)
1993
34
Osteofibrous dysplasia: clinicopathologic study of 80 cases. (8276381)
1993
35
Polyostotic lesions compatible with osteofibrous dysplasia. A case report. (8117510)
1993
36
Answer please. Osteofibrous dysplasia. (8290405)
1993
37
Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature. (1563159)
1992
38
Osteofibrous dysplasia of the tibia treated by bracing. (1428320)
1992
39
Synovial sarcoma associated with osteofibrous dysplasia. A case report and review of the literature. (1510197)
1992
40
Juvenile intracortical adamantinoma of the tibia with predominant osteofibrous dysplasia-like features. (1724319)
1991
41
Congenital ossifying fibroma (osteofibrous dysplasia) of the tibia--a case report. (1749686)
1991
42
Case report 587: Adamantinoma of the tibia mimicking osteofibrous dysplasia. (2326657)
1990
43
MRI findings in osteofibrous dysplasia. (2607907)
1989
44
Morphologic diversity of long bone adamantinoma. The concept of differentiated (regressing) adamantinoma and its relationship to osteofibrous dysplasia. (2804923)
1989
45
Osteofibrous dysplasia. A report of two cases. (3201274)
1988
46
Osteofibrous dysplasia of the tibia and fibula. (3205593)
1988
47
Radiologic case study. Osteofibrous dysplasia. (3615297)
1987
48
Osteofibrous dysplasia (ossifying fibroma) of the tibia and fibula and adamantinoma. A case report. (6475846)
1984
49
Osteofibrous dysplasia of the tibia and fibula. (7204433)
1981
50
Osteofibrous dysplasia of long bones a new clinical entity. (1024109)
1976

Variations for Osteofibrous Dysplasia

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Expression for genes affiliated with Osteofibrous Dysplasia

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Search GEO for disease gene expression data for Osteofibrous Dysplasia.

Pathways for genes affiliated with Osteofibrous Dysplasia

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GO Terms for genes affiliated with Osteofibrous Dysplasia

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Cellular components related to Osteofibrous Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.0BGLAP, SPARC
2dendriteGO:00304259.1BGLAP, GNAS, NF1

Biological processes related to Osteofibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to gravityGO:000962910.2BGLAP, SPARC
2negative regulation of transcription factor import into nucleusGO:004299210.0CD36, NF1
3negative regulation of angiogenesisGO:00165259.9NF1, SPARC
4regulation of bone resorptionGO:00451249.9BGLAP, NF1
5bone developmentGO:00603489.9BGLAP, GNAS
6cognitionGO:00508909.9GNAS, NF1
7negative regulation of endothelial cell proliferationGO:00019379.9NF1, SPARC
8response to vitamin DGO:00332809.7BGLAP, SPP1
9cellular response to growth factor stimulusGO:00713639.6BGLAP, SPARC
10regulation of angiogenesisGO:00457659.6KRT1, NF1

Sources for Osteofibrous Dysplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet