MCID: OST032
MIFTS: 39

Osteofibrous Dysplasia malady

Bone category

Summaries for Osteofibrous Dysplasia

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

MalaCards: Osteofibrous Dysplasia, also known as jaffe-campanacci syndrome, is related to fibrous dysplasia and mccune albright syndrome. An important gene associated with Osteofibrous Dysplasia is GNAS (GNAS complex locus), and among its related pathways are Estrogen signaling pathway and Non-integrin membrane-ECM interactions. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Osteofibrous Dysplasia

Sources:
43NIH Rare Diseases, 61UMLS, 45Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

osteofibrous dysplasia 43 45 61
jaffe-campanacci syndrome 43 61
ossifying fibroma 43 61
intracortical fibrous dysplasia 43


Related Diseases for Osteofibrous Dysplasia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteofibrous Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia30.6FOS, SPARC, GNAS, BGLAP
2mccune albright syndrome30.4GNAS
3neurofibromatosis30.4NF1
4adenoma30.4KRT19, MUC1, GNAS
5osteoblastoma30.2SPARC
6fibromatosis30.2VIM
7adenomatoid tumor30.2VIM
8primary hyperparathyroidism30.2BGLAP, CD36
9synovial sarcoma30.1NF1, VIM, KRT19, KRT1, MUC1
10fibromatosis multiple non ossifying10.6
11ossifying fibroma10.6
12pyogenic granuloma10.5
13bone fracture10.4
14n syndrome10.3
15monostotic fibrous dysplasia10.3
16pseudoarthrosis10.3
17congenital pseudoarthrosis10.3
18psammomatous meningioma10.1
19bilateral retinoblastoma10.1
20chronic apical periodontitis10.1
21orbital cellulitis10.1
22cellulitis10.1
23exophthalmos10.1
24fanconi syndrome10.1
25juxtacortical chondrosarcoma10.1
26skull base meningioma10.1
27aneurysmal bone cysts10.1
28florid cemento-osseous dysplasia10.1
29sinusitis10.1
30lipoblastoma10.1
31costello syndrome10.1
32thyroid adenoma10.0GNAS
33leydig cell tumor10.0GNAS
34obesity10.0GNAS
35hypothyroidism10.0GNAS
36prolactinoma10.0GNAS
37pituitary adenoma10.0GNAS
38idiopathic juvenile osteoporosis10.0CD36
39glomerulonephritis10.0SPP1
40biliary atresia10.0SPP1
41gigantism10.0GNAS
42oral cancer10.0KRT19
43growth hormone deficiency10.0BGLAP
44hypercalcemia10.0BGLAP
45alzheimer's disease10.0KRT1
46multiple sclerosis10.0SPP1
47colon adenocarcinoma10.0FOS
48endometrial carcinoma10.0FOS
49interstitial lung disease10.0MUC1
50thymic carcinoma10.0MUC1

Graphical network of the top 20 diseases related to Osteofibrous Dysplasia:



Diseases related to osteofibrous dysplasia

Clinical Features for Osteofibrous Dysplasia

Drugs & Therapeutics for Osteofibrous Dysplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteofibrous Dysplasia

Drug clinical trials:

Search ClinicalTrials for Osteofibrous Dysplasia

Search NIH Clinical Center for Osteofibrous Dysplasia

Search CenterWatch for Osteofibrous Dysplasia

Genetic Tests for Osteofibrous Dysplasia

Anatomical Context for Osteofibrous Dysplasia

Animal Models for Osteofibrous Dysplasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Osteofibrous Dysplasia

Sources:
51PubMed
See all sources

Articles related to Osteofibrous Dysplasia:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. (24199850)
2014
2
Neonatal osteofibrous dysplasia associated with pathological tibia fracture: a case report and review of the literature. (21383639)
2012
3
Marginal excision and Ilizarov hemicallotasis for osteofibrous dysplasia of the tibia: a case report. (21164362)
2011
4
Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia. (21499851)
2011
5
Is there a link between osteofibrous dysplasia and adamantinoma? (22079612)
2011
6
Osteofibrous dysplasia and adamantinoma. (20511441)
2010
7
Minimally invasive plate osteosynthesis for osteofibrous dysplasia of the tibia: a case report. (21187556)
2010
8
Congenital osteofibrous dysplasia of the tibia, associated with pseudoarthrosis of the ipsilateral fibula. (18946584)
2008
9
Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. (18300815)
2008
10
Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. (18690429)
2008
11
Treatment of osteofibrous dysplasia and associated lesions. (17594160)
2007
12
Congenital osteofibrous dysplasia associated with pseudoarthrosis of the tibia and fibula. (16944141)
2007
13
Osteofibrous dysplasia of the tibia. (17259434)
2007
14
Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? (16645116)
2006
15
Familial osteofibrous dysplasia. A case series. (16203897)
2005
16
Effective analgesia with tramadol for osteofibrous dysplasia refractory to NSAID medication. (16005174)
2005
17
Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. (15258702)
2004
18
Osteofibrous dysplasia treated with distraction osteogenesis: a report of two cases. (15449128)
2004
19
Giant osteofibrous dysplasia (ossifying fibroma) of the tibia: case report and review of treatment modalities. (18521395)
2004
20
Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst. (12574919)
2003
21
Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. (12679847)
2003
22
CD99 positive adamantinoma of the ulna with ipsilateral discrete osteofibrous dysplasia. (12616068)
2003
23
Osteofibrous dysplasia: a review of the literature and presentation of an additional 3 cases. (14620087)
2003
24
Osteofibrous dysplasia in a Japanese boy with Costello syndrome. (14564166)
2003
25
Comparative study of fibrous dysplasia and osteofibrous dysplasia: histopathological, immunohistochemical, argyrophilic nucleolar organizer region and DNA ploidy analysis. (11564214)
2001
26
Osteofibrous dysplasia of the ulna. (11764436)
2001
27
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. (11272890)
2000
28
Osteofibrous dysplasia of the tibia: case report and review of the literature. (10709600)
1999
29
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c-fos and c-jun products and bone matrix proteins: a clinicopathologic review and immunohistochemical study of c-fos, c-jun, type I collagen, osteonectin, osteopontin, and osteocalcin. (10667418)
1999
30
Neonatal osteofibrous dysplasia: report of two cases. (8677152)
1996
31
Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinoma. (8156503)
1994
32
Cytokeratin expression and distribution in adamantinoma of the long bones and osteofibrous dysplasia of tibia and fibula. An immunohistochemical study correlated to histogenesis. (7525449)
1994
33
Aggressive bone tumorous lesion in infancy: osteofibrous dysplasia of the tibia and fibula. (8376555)
1993
34
Osteofibrous dysplasia: clinicopathologic study of 80 cases. (8276381)
1993
35
Polyostotic lesions compatible with osteofibrous dysplasia. A case report. (8117510)
1993
36
Answer please. Osteofibrous dysplasia. (8290405)
1993
37
Osteofibrous dysplasia of the tibia treated by bracing. (1428320)
1992
38
Synovial sarcoma associated with osteofibrous dysplasia. A case report and review of the literature. (1510197)
1992
39
Cortical osteofibrous dysplasia of long bone and its relationship to adamantinoma. A clinicopathologic study of 30 cases. (1599019)
1992
40
Juvenile intracortical adamantinoma of the tibia with predominant osteofibrous dysplasia-like features. (1724319)
1991
41
Congenital ossifying fibroma (osteofibrous dysplasia) of the tibia--a case report. (1749686)
1991
42
Case report 587: Adamantinoma of the tibia mimicking osteofibrous dysplasia. (2326657)
1990
43
MRI findings in osteofibrous dysplasia. (2607907)
1989
44
Morphologic diversity of long bone adamantinoma. The concept of differentiated (regressing) adamantinoma and its relationship to osteofibrous dysplasia. (2804923)
1989
45
Case report 543. Osteofibrous dysplasia of tibia. (2749297)
1989
46
Osteofibrous dysplasia. A report of two cases. (3201274)
1988
47
Osteofibrous dysplasia of the tibia and fibula. (3205593)
1988
48
Osteofibrous dysplasia of the tibia and fibula. (7204433)
1981
49
Osteofibrous dysplasia. (7364849)
1980
50
Osteofibrous dysplasia of long bones a new clinical entity. (1024109)
1976

Genetic Variations for Osteofibrous Dysplasia

Expression for genes affiliated with Osteofibrous Dysplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteofibrous Dysplasia

Search GEO for disease gene expression data for Osteofibrous Dysplasia.

Pathways for genes affiliated with Osteofibrous Dysplasia

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GNAS, FOS
2
Hide members
9.3SPP1, SPARC, CD36
39.0FOS, BGLAP, SPP1
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0BGLAP, FOS, SPP1
58.9KRT1, KRT19, VIM
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
8.7FOS, BGLAP, GNAS, SPP1
7
Hide members
8.4VIM, FOS, NF1, MUC1, SPP1

Compounds for genes affiliated with Osteofibrous Dysplasia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5NF1
2forskolin45 50 1112.4VIM
3ti6al4v459.8CD36, BGLAP
4chitosan459.6BGLAP, CD36, SPP1
5tartrate459.5CD36, VIM, BGLAP
6alginate459.5CD36, SPP1, BGLAP
7dexamethasone45 50 29 1112.4BGLAP, SPP1, FOS
825-hydroxyvitamin d459.4SPP1, CD36, BGLAP
9pyridinoline459.3BGLAP, CD36, SPARC
10chondroitin sulfate45 2410.3VIM, SPP1, SPARC, CD36
11matrigel459.3VIM, MUC1, KRT19
12aspartate459.2SPP1, KRT1, KRT19
13tgf beta1459.2CD36, SPARC, VIM, SPP1
14fluoride459.2BGLAP, NF1, SPP1
15b 723459.2VIM, MUC1, KRT19
16alizarin459.1BGLAP, CD36, SPARC, SPP1
17hydrocortisone45 2 60 1112.1BGLAP, VIM, CD36, MUC1
18agar458.9SPP1, MUC1, FOS, VIM
19hematoxylin458.9VIM, KRT19, MUC1, KRT1
20heparin45 29 11 2411.9BGLAP, CD36, SPARC, SPP1
21hydroxyproline45 11 2410.9BGLAP, CD36, SPARC
22adriamycin458.9CD36, KRT19, MUC1, VIM
23cytochalasin d45 609.9VIM, SPP1, CD36, NF1, FOS
2412-o-tetradecanoylphorbol 13-acetate458.8FOS, MUC1, KRT1, VIM
25creatinine458.8CD36, BGLAP, KRT19, SPP1
26titanium458.7SPARC, VIM, BGLAP, CD36, SPP1
27hydroxyapatite458.7SPP1, VIM, BGLAP, CD36, SPARC
28gnrh458.7BGLAP, VIM, GNAS, FOS, CD36
29genistein45 29 60 2 11 2413.7VIM, CD36, SPP1, FOS, SPARC
30vitamin d458.7CD36, BGLAP, VIM, SPARC, SPP1
31hyaluronic acid45 249.7KRT19, SPP1, CD36, MUC1, VIM
32calcitriol45 60 11 2411.6FOS, CD36, BGLAP, SPP1, SPARC
33cyclic amp45 249.6MUC1, NF1, FOS, GNAS, VIM
34ribonucleic acid458.6KRT19, FOS, SPP1, MUC1, GNAS
35retinoid458.5FOS, VIM, SPP1, KRT19, KRT1
36ascorbic acid45 249.4SPP1, SPARC, CD36, BGLAP
37arginine458.4NF1, BGLAP, SPP1, VIM, KRT1, GNAS
38oligonucleotide458.3FOS, GNAS, SPARC, SPP1, NF1, VIM
39h2o2458.3SPP1, BGLAP, CD36, FOS, VIM
40thymidine45 249.2GNAS, FOS, MUC1, KRT19, SPARC
41sb 20358045 609.2BGLAP, SPP1, VIM, SPARC, CD36, FOS
42serine457.9GNAS, KRT1, FOS, NF1, KRT19, BGLAP
43cysteine457.6MUC1, CD36, NF1, GNAS, BGLAP, VIM
44testosterone45 60 11 2410.5SPARC, VIM, BGLAP, MUC1, KRT19, KRT1
45progesterone45 60 29 11 2411.4SPARC, VIM, GNAS, NF1, MUC1, KRT1
46tyrosine457.2MUC1, KRT19, KRT1, SPARC, SPP1, NF1
47vegf457.0KRT19, BGLAP, MUC1, FOS, VIM, CD36
48paraffin456.8KRT19, SPARC, BGLAP, NF1, VIM, MUC1
49calcium45 50 11 249.3BGLAP, GNAS, KRT19, NF1, MUC1, CD36
50retinoic acid45 247.2VIM, BGLAP, FOS, NF1, SPP1, SPARC

GO Terms for genes affiliated with Osteofibrous Dysplasia

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.3SPP1, BGLAP
2dendriteGO:0304259.1NF1, GNAS, BGLAP

Biological processes related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription factor import into nucleusGO:0429929.9CD36, NF1
2DNA methylationGO:0063069.7GNAS, FOS
3positive regulation of Ras GTPase activityGO:0323209.6GNAS, NF1
4response to vitamin DGO:0332809.6BGLAP, SPP1
5regulation of bone resorptionGO:0451249.5NF1, BGLAP
6regulation of angiogenesisGO:0457659.4KRT1, NF1
7bone developmentGO:0603489.3SPARC, BGLAP
8osteoblast differentiationGO:0016499.2SPP1, BGLAP, NF1
9response to gravityGO:0096299.0SPARC, BGLAP, FOS

Molecular functions related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:0508409.7SPP1, SPARC

Products for genes affiliated with Osteofibrous Dysplasia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteofibrous Dysplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet