MCID: OST032
MIFTS: 37

Osteofibrous Dysplasia malady

Bone diseases category

Summaries for Osteofibrous Dysplasia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Osteofibrous dysplasia (also known as ossifying fibroma) is a rare, benign non-neoplastic condition with... more...

MalaCards: Osteofibrous Dysplasia, also known as jaffe-campanacci syndrome, is related to fibrous dysplasia and hyperparathyroidism. An important gene associated with Osteofibrous Dysplasia is GNAS (GNAS complex locus), and among its related pathways are Estrogen signaling pathway and Non-integrin membrane-ECM interactions. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Osteofibrous Dysplasia

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteofibrous dysplasia 42 44 60
jaffe-campanacci syndrome 42 60
ossifying fibroma 42 60
intracortical fibrous dysplasia 42


Related Diseases for Osteofibrous Dysplasia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteofibrous Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia30.6FOS, SPARC, GNAS, BGLAP
2hyperparathyroidism30.5BGLAP, NF1
3neurofibromatosis30.5NF1
4meningioma30.5SPARC, KRT1, MUC1, NF1, VIM
5mccune albright syndrome30.4GNAS
6chondrosarcoma30.3CD36, MUC1, VIM, SPARC, KRT19
7osteoblastoma30.1SPARC
8adenomatoid tumor30.1VIM
9hyperthyroidism30.1GNAS, BGLAP
10primary hyperparathyroidism30.1BGLAP, CD36
11adenoma30.1KRT19, MUC1, GNAS
12giant cell tumor30.1VIM, BGLAP, MUC1
13retinoblastoma30.1SPARC, NF1, FOS
14osteosarcoma30.1SPP1, SPARC, CD36, FOS, BGLAP
15sarcoma30.1NF1, MUC1, VIM
16synovial sarcoma30.1NF1, VIM, KRT19, KRT1, MUC1
17fibromatosis multiple non ossifying10.6
18ossifying fibroma10.5
19long bone adamantinoma10.5
20bone fracture10.4
21gingivitis10.4
22pseudoarthrosis10.3
23periodontitis10.3
24psammomatous meningioma10.1
25bilateral retinoblastoma10.1
26chronic apical periodontitis10.1
27orbital cellulitis10.1
28cellulitis10.1
29costello syndrome10.1
30exophthalmos10.1
31fanconi syndrome10.1
32juxtacortical chondrosarcoma10.1
33orbital cyst10.1
34epulis10.1
35parathyroid adenoma10.1
36periostitis10.1
37skull base meningioma10.1
38sphenoid sinusitis10.1
39thyroid adenoma10.0GNAS
40leydig cell tumor10.0GNAS
41obesity10.0GNAS
42hypothyroidism10.0GNAS
43prolactinoma10.0GNAS
44pituitary adenoma10.0GNAS
45idiopathic juvenile osteoporosis10.0CD36
46glomerulonephritis10.0SPP1
47biliary atresia10.0SPP1
48gigantism10.0GNAS
49oral cancer10.0KRT19
50growth hormone deficiency10.0BGLAP

Graphical network of the top 20 diseases related to Osteofibrous Dysplasia:



Diseases related to osteofibrous dysplasia

Clinical Features for Osteofibrous Dysplasia

About this section

Drugs & Therapeutics for Osteofibrous Dysplasia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteofibrous Dysplasia

Drug clinical trials:

Search ClinicalTrials for Osteofibrous Dysplasia

Search NIH Clinical Center for Osteofibrous Dysplasia

Search CenterWatch for Osteofibrous Dysplasia

Genetic Tests for Osteofibrous Dysplasia

About this section

Anatomical Context for Osteofibrous Dysplasia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Osteofibrous Dysplasia:

32
Bone

Animal Models for Osteofibrous Dysplasia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Osteofibrous Dysplasia:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1NF1, CD36, SPP1
2MP:00053798.9KRT19, NF1, FOS
3MP:00053708.9GNAS, NF1, MUC1, CD36, SPP1
4MP:00053768.6SPP1, SPARC, KRT1, CD36, NF1, GNAS
5MP:00036318.5GNAS, FOS, NF1, KRT19
6MP:00107718.5GNAS, FOS, KRT19, KRT1, SPP1
7MP:00020068.1FOS, NF1, KRT19, SPARC, SPP1
8MP:00053918.1VIM, FOS, NF1, MUC1, CD36, SPARC
9MP:00053978.1SPP1, SPARC, CD36, NF1, FOS, GNAS
10MP:00053908.1GNAS, NF1, CD36, KRT19, SPARC, SPP1
11MP:00053867.9VIM, GNAS, FOS, NF1, CD36, SPARC
12MP:00053877.9VIM, GNAS, FOS, NF1, CD36, SPARC
13MP:00053857.8VIM, GNAS, NF1, CD36, KRT19, SPP1
14MP:00053847.4VIM, GNAS, FOS, NF1, CD36, KRT19
15MP:00053787.4VIM, GNAS, FOS, NF1, CD36, KRT19
16MP:00107687.2VIM, GNAS, FOS, NF1, CD36, KRT19

Publications for Osteofibrous Dysplasia

About this section

Genetic Variations for Osteofibrous Dysplasia

About this section

Expression for genes affiliated with Osteofibrous Dysplasia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteofibrous Dysplasia

Search GEO for disease gene expression data for Osteofibrous Dysplasia.

Pathways for genes affiliated with Osteofibrous Dysplasia

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 51QIAGEN
See all sources

Pathways related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7FOS, GNAS
2
Hide members
9.3SPP1, SPARC, CD36
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0BGLAP, FOS, SPP1
49.0BGLAP, FOS, SPP1
58.9KRT1, KRT19, VIM
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
8.7SPP1, FOS, GNAS, BGLAP
7
Hide members
8.4VIM, FOS, NF1, MUC1, SPP1

Compounds for genes affiliated with Osteofibrous Dysplasia

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5NF1
2forskolin44 49 1112.4VIM
3ti6al4v449.8CD36, BGLAP
4chitosan449.6BGLAP, CD36, SPP1
5tartrate449.5CD36, VIM, BGLAP
6alginate449.5CD36, SPP1, BGLAP
7dexamethasone44 49 28 1112.4BGLAP, SPP1, FOS
825-hydroxyvitamin d449.4SPP1, CD36, BGLAP
9pyridinoline449.3BGLAP, CD36, SPARC
10chondroitin sulfate44 2410.3VIM, SPP1, SPARC, CD36
11matrigel449.3VIM, MUC1, KRT19
12aspartate449.2SPP1, KRT1, KRT19
13tgf beta1449.2CD36, SPARC, VIM, SPP1
14fluoride449.2BGLAP, NF1, SPP1
15b 723449.2VIM, MUC1, KRT19
16alizarin449.1BGLAP, CD36, SPARC, SPP1
17hydrocortisone44 2 59 1112.1BGLAP, VIM, CD36, MUC1
18agar448.9SPP1, MUC1, FOS, VIM
19hematoxylin448.9VIM, KRT19, MUC1, KRT1
20heparin44 28 11 2411.9BGLAP, CD36, SPARC, SPP1
21hydroxyproline44 11 2410.9BGLAP, CD36, SPARC
22adriamycin448.9CD36, KRT19, MUC1, VIM
23cytochalasin d44 599.9VIM, SPP1, CD36, NF1, FOS
2412-o-tetradecanoylphorbol 13-acetate448.8FOS, MUC1, KRT1, VIM
25creatinine448.8CD36, BGLAP, KRT19, SPP1
26titanium448.7SPARC, VIM, BGLAP, CD36, SPP1
27hydroxyapatite448.7SPP1, VIM, BGLAP, CD36, SPARC
28gnrh448.7BGLAP, VIM, GNAS, FOS, CD36
29genistein44 28 59 2 11 2413.7VIM, CD36, SPP1, FOS, SPARC
30vitamin d448.7CD36, BGLAP, VIM, SPARC, SPP1
31hyaluronic acid44 249.7KRT19, SPP1, CD36, MUC1, VIM
32calcitriol44 59 11 2411.6FOS, CD36, BGLAP, SPP1, SPARC
33cyclic amp44 249.6MUC1, NF1, FOS, GNAS, VIM
34ribonucleic acid448.6KRT19, FOS, SPP1, MUC1, GNAS
35retinoid448.5FOS, VIM, SPP1, KRT19, KRT1
36ascorbic acid44 249.4SPP1, SPARC, CD36, BGLAP
37arginine448.4NF1, BGLAP, SPP1, VIM, KRT1, GNAS
38oligonucleotide448.3FOS, GNAS, SPARC, SPP1, NF1, VIM
39h2o2448.3SPP1, BGLAP, CD36, FOS, VIM
40thymidine44 249.2GNAS, FOS, MUC1, KRT19, SPARC
41sb 20358044 599.2BGLAP, SPP1, VIM, SPARC, CD36, FOS
42serine447.9GNAS, KRT1, FOS, NF1, KRT19, BGLAP
43cysteine447.6MUC1, CD36, NF1, GNAS, BGLAP, VIM
44testosterone44 59 11 2410.5SPARC, VIM, BGLAP, MUC1, KRT19, KRT1
45progesterone44 59 28 11 2411.4SPARC, VIM, GNAS, NF1, MUC1, KRT1
46tyrosine447.2MUC1, KRT19, KRT1, SPARC, SPP1, NF1
47vegf447.0KRT19, BGLAP, MUC1, FOS, VIM, CD36
48paraffin446.8KRT19, SPARC, BGLAP, NF1, VIM, MUC1
49calcium44 49 11 249.3BGLAP, GNAS, KRT19, NF1, MUC1, CD36
50retinoic acid44 247.2VIM, BGLAP, FOS, NF1, SPP1, SPARC

GO Terms for genes affiliated with Osteofibrous Dysplasia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.3SPP1, BGLAP
2dendriteGO:0304259.1NF1, GNAS, BGLAP

Biological processes related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription factor import into nucleusGO:0429929.9CD36, NF1
2DNA methylationGO:0063069.7FOS, GNAS
3positive regulation of Ras GTPase activityGO:0323209.6NF1, GNAS
4response to vitamin DGO:0332809.6BGLAP, SPP1
5regulation of bone resorptionGO:0451249.5NF1, BGLAP
6regulation of angiogenesisGO:0457659.4KRT1, NF1
7bone developmentGO:0603489.3SPARC, BGLAP
8osteoblast differentiationGO:0016499.2BGLAP, NF1, SPP1
9response to gravityGO:0096299.0SPARC, FOS, BGLAP

Molecular functions related to Osteofibrous Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:0508409.7SPP1, SPARC

Products for genes affiliated with Osteofibrous Dysplasia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteofibrous Dysplasia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet